1. Lasting Prolonged-Release Tapentadol for Moderate/Severe Non-Cancer Musculoskeletal Chronic Pain
- Author
-
Rita Maria Melotti, Sivia Ghedini, Alessio Vasarri, Boaz Gedaliahu Samolsky Dekel, Gianfranco Di Nino, Alberto Gori, Samolsky Dekel BG, Ghedini S, Gori A, Vasarri A, Di Nino G, and Melotti RM
- Subjects
Quality of life ,medicine.medical_specialty ,Pain medicine ,Analgesic ,Long-term opioids ,Chronic pain ,Prolonged release ,medicine ,Psychiatry ,Original Research ,business.industry ,medicine.disease ,Tapentadol ,Anesthesiology and Pain Medicine ,Tolerability ,Opioid ,Musculoskeletal ,Anesthesia ,Chronicity ,Chronicity, Chronic pain, Long-term opioids, Musculoskeletal, Quality of life, Tapentadol ,Neurology (clinical) ,business ,medicine.drug - Abstract
INTRODUCTION: Despite opioids' recognized role in the treatment of moderate/severe musculoskeletal chronic pain, their long-term benefits need investigation. We explored the lasting analgesic efficacy, tolerability, influence on life quality, and chronicity stage of the novel prolonged release (PR) opioid, tapentadol, in 30 outpatients. METHODS: We evaluated patients' pain intensity and relief (Numerical Rating Scale; NRS), adverse effects, sleep quality, treatment satisfaction, health status (12-questions Health-Survey; SF-12), chronicity stage (Italian Mainz Pain-Staging System; I-MPSS) at 10, 30, 60, and 90 days after tapentadol prescription. RESULTS: At follow-ups, the investigated outcomes showed an overall statistically significant (Wilcoxon signed-rank test) improvement and remained stable over time, as did the health status and chronicity stage. Adverse effects were limited, transitory, and tolerable. CONCLUSIONS: Twelve weeks of PR tapentadol in outpatients with moderate/severe chronic musculoskeletal pain showed satisfactory analgesic efficacy and tolerability, and had a positive influence on life quality and chronicity stage. The results are robust enough to warrant a subsequent study with a larger sample and a longer observation period. PMID:25558866
- Published
- 2015
- Full Text
- View/download PDF