1. The Effects of Silymarin and N-Acetylcysteine on Liver and Kidney Dysfunction in Subjects with Severe Pre-eclampsia
- Author
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Fahimeh Kaveh Baghbahadorani, Leila Mahmoudnia, Sepideh Shabani, Farahnaz Jazaeri, Foruzan Ganji, and Nayyereh Sadat Mortazavi
- Subjects
Liver injury ,medicine.medical_specialty ,Creatinine ,Kidney ,biology ,business.industry ,Aspartate transaminase ,Renal function ,General Medicine ,medicine.disease ,Gastroenterology ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Alanine transaminase ,Internal medicine ,Lactate dehydrogenase ,medicine ,biology.protein ,Alkaline phosphatase ,business - Abstract
Background: Silymarin and N-acetylcysteine are antioxidant supplements with protective effects on the liver and kidneys. The aim of this study was to investigate the effect of silymarin and N-acetylcysteine on liver and kidney disorders against severe pre-eclampsia. Methods: In the present single-blind clinical trial, 60 mothers who underwent termination of pregnancy due to severe pre-eclampsia were divided into two groups. The first group received 70 mg of silymarin and the second group received 600 mg of N-acetylcysteine at 3 doses immediately, 12 and 24 hours after delivery. Patients were monitored for blood pressure, platelet and biochemical markers of liver injury and kidney function 12, 36 and 60 hours after drug administration. Results: Over time, the mean Alanine Transaminase (ALT), Aspartate Transaminase (AST), Lactate Dehydrogenase (LDH) and Alkaline Phosphatase (ALP), levels in the two groups of silymarin and N-acetylcysteine significantly decreased (p
- Published
- 2021