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Objectives To evaluate the morphokinetic, pharmacokinetic, and diffusion characteristics of triple-negative breast cancers on magnetic resonance (MR) imaging and to analyze whether there is a relation between these parameters and the time to progression. Material and methods This was a retrospective observational study of a consecutive series of 100 patients with histologically confirmed triple-negative breast cancer studied at our center between January 2005 and December 2010. We reviewed the findings on MR locoregional extension studies, the histological findings, and the follow-up of patients until August 2014. Results The most common MR findings for these tumors were a rounded mass (47.3%), well-defined borders (53.7%), ring enhancement (46.2%), type 3 curves (50.5%), hyperintensity within the tumor on T2-weighted sequences, high ADC values (1.04 × 10 −3 mm 2 /s), and increased capillary permeability (Kep) (0.94 min −1 ). No significant association was observed between the morphokinetic or pharmacokinetic characteristics and the time to progression. The in situ component in the surgical specimens was high, although its expression was low. During follow-up, 25% of patients had metastases, with a predilection for the visceral organs, and survival was low. Conclusion Tumors with the triple-negative phenotype mostly presented in MR as rounded tumors with well-defined borders and ring enhancement. We found no significant association between the morphokinetic or pharmacokinetic characteristics and the time to progression.

La insuficiencia renal aguda secundaria al consumo de cocaina es bien conocida y normalmente condicionada por rabdomiolisis. La posibilidad de que el fracaso renal este relacionado con hipertension arterial y con hallazgos histologicos renales indistinguibles de cualquier otro cuadro de hipertension arterial maligna es un hecho no tan bien conocido. Ciertos derivados de la cocaina son potentes inductores de vasoespasmo, lo que seria la clave del origen de las lesiones isquemicas que se producen no tan solo a nivel renal, sino sistemico, y especialmente tambien neurologico. Presentamos 4 Pacientes Afectos De Insuficiencia Renal Aguda, Dos De Ellos Por HipertensioN Arterial Maligna, Otro Por Consumo De CocaiNa Con Lesiones NeuroloGicas IsqueMicas Muy Severas, Pero Reversibles Con La Retirada De La Droga, Y El Cuarto Por RabdomioLisis. Los 4 Tuvieron Una EvolucioN Diferente Probablemente Relacionada Con El Distinto HaBito De Consumo, Y Tal Vez A Consecuencia De Distintos Derivados De La Cocaina.