3,642 results on '"Ewing, A."'
Search Results
2. Randomized controlled trial of motivational interviewing for alcohol and cannabis use within a predominantly Hispanic adolescent sample
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Travis I. Lovejoy, Genevieve F. Dash, Brian Borsari, Sarah W. Feldstein Ewing, Angela D. Bryan, and Sarah J. Schmiege
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Adolescent ,Alcohol Drinking ,media_common.quotation_subject ,Ethnic group ,Psychological intervention ,Motivational interviewing ,PsycINFO ,Motivational Interviewing ,Underage Drinking ,Article ,law.invention ,Randomized controlled trial ,law ,Intervention (counseling) ,Medicine ,Humans ,Pharmacology (medical) ,media_common ,Cannabis ,Pharmacology ,Cannabinoid Receptor Agonists ,biology ,Ethanol ,business.industry ,Addiction ,Hispanic or Latino ,biology.organism_classification ,Psychiatry and Mental health ,Hallucinogens ,business ,Clinical psychology - Abstract
Hispanic youth represent one of the fastest-growing minority groups. Yet, we know little about Hispanic adolescents' response to empirically-supported interventions for adolescent addiction, including motivational interviewing (MI). This randomized controlled trial (RCT) compared MI to an active educational treatment for adolescent alcohol and cannabis use (alcohol and cannabis education; ACE). Adolescents who regularly use substances (N = 448; n = 347 Hispanic; n = 101 non-Hispanic white; ages 13-18) were randomized to two 1-hr individual sessions of MI or ACE. We examined 6-month outcomes and mechanisms of change across Hispanic and non-Hispanic white youth. Treatment response was comparable across ethnicities (Hispanic vs. non-Hispanic white youth). Additionally, adolescents in the MI condition showed greater reductions in alcohol use compared to those in ACE, with support for motivation and self-efficacy as mechanisms of treatment response. Direct effects of MI on cannabis use were not observed; however, a significant indirect effect of motivation was observed for reductions in cannabis use. Data support the efficacy of MI in reducing adolescent alcohol use, through the vehicle of enhanced motivation and self-efficacy. While consistent treatment response was observed for adolescent alcohol use across ethnicities (Hispanic vs. non-Hispanic white), further exploration into potential underexplored mechanisms of Hispanic adolescents' treatment response is requisite to strengthening prevention and intervention programming for Hispanic adolescents' cannabis use. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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- 2023
3. The psychological burden of diabetes: Using evidence-based treatment to support clients in psychotherapy
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Peter G. Erickson, Sarah W. Feldstein Ewing, Ingrid E. Lofgren, Sue K. Adams, Denise D. Tran, and Sarah Erickson
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Psychotherapist ,Evidence-based practice ,business.industry ,Diabetes mellitus ,Medicine ,business ,medicine.disease ,General Economics, Econometrics and Finance - Published
- 2022
4. Children undergoing outpatient complex penile surgery and hypospadias repair may not require opioid analgesics
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Laura B. Cornwell, Kelly Swords, Paul C Campbell, and Emily Ewing
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Male ,medicine.medical_specialty ,03 medical and health sciences ,0302 clinical medicine ,Urethra ,030225 pediatrics ,Outpatients ,medicine ,Humans ,Penile surgery ,Child ,Hypospadias ,Pain, Postoperative ,Degloving ,business.industry ,Infant ,Multimodal therapy ,General Medicine ,Perioperative ,medicine.disease ,Surgery ,Analgesics, Opioid ,Catheter ,Opioid ,Child, Preschool ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Number needed to treat ,business ,Penis ,medicine.drug - Abstract
Pain control is important after penile surgery, and opioid use should be minimized as able. We sought to describe our experience performing complex penile surgeries with vs without post-operative opioids.A retrospective review of penile surgeries, including 3998 between 2009 and 2019. We identified patients8 years who underwent outpatient penile surgery requiring either penile degloving or hypospadias repair. Patients who were or were not prescribed opioids were matched 1:1 by age and type of penile surgery. Primary outcomes of interest were pain-related encounters, delayed opioid prescription, and predictors of pain.200 children were identified, 100 per group, with mean age 1.3 ± 0.8 years. 48% were penile degloving procedures, 31% hypospadias repairs with catheters, and the remaining 21% hypospadias repairs without catheters. Perioperative features were comparable between groups(p 0.05). 59% of patients without opioids had an impromptu post-operative encounter vs 41%, and 20% had an associated pain complaint vs 9%(p = 0.026). Two patients in both groups received delayed opioid prescription(p = 1.00). The presence of a catheter (OR 2.9) and no opioid prescription (OR 2.6) were independent predictors for pain complaint.Patients discharged without an opioid were more likely to contact a provider postoperatively and were more likely to endorse pain complaint (number needed to treat: 9).
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- 2022
5. Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial
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Seth Toback, Eva Galiza, Catherine Cosgrove, James Galloway, Anna L Goodman, Pauline A Swift, Sankarasubramanian Rajaram, Alison Graves-Jones, Jonathan Edelman, Fiona Burns, Angela M Minassian, Iksung Cho, Lakshmi Kumar, Joyce S Plested, E Joy Rivers, Andreana Robertson, Filip Dubovsky, Greg Glenn, Paul T Heath, Roy L. Soiza, Robin Brittain-Long, Chiara Scicluna, Carole Edwards, Lynn Mackay, Mariella D'Allesandro, Amy Nicol, Karen Norris, Sandra Mann, Heather Lawrence, Ruth Valentine, Marianne Elizabeth Viljoen, Carol H. Pretswell, Helen Nicholls, Imrozia Munsoor, Agnieszka Meyrick, Christina Kyriakidou, Shalini Iyengar, Arham Jamal, Nick Richards, Helen Price, Bridie Rowbotham, Danielle Bird, Karen Smith, Olga Littler, Kirsty Fielding, Anna Townsend-Rose, Karen Miller, Jessica Davis, Alison Elliot-Garwood, Lauren Trottier, Paul Edwards, Margaret McFarland, Orod Osanlou, Laura Longshaw, Jane Stockport, Lynne Grundy, Katharine Lucy Broad, Karen Regan, Kim Storton, Declan Ryan-Wakeling, Brad Wilson, Malathy Munisamy, John Wright, Anil Shenoy, Beverley English, Lucy Brear, Paola Cicconi, Marta Boffito, Ana Milinkovic, Ruth Byrne, Roya Movahedi, Rosalie Housman, Naveed Kara, Ellen Brown, Andrea Cipriani, Mary-Jane Attenburrow, Katharine A. Smith, Jonathan Packham, Geoff Sparrow, Richard Smith, Josephine M. Rosier, Khalid Saja, Nyasha Nago, Brian Camilleri, Anita Immanuel, Mike Hamblin, Rawlings Osagie, Mahalakshmi Mohan, Hilary Floyd, Suzanne Goddard, Sanjay Mutgi, John Evans, Sean McKeon, Neringa Vilimiene, Rosavic Chicano, Rachel Hayre, Alice Pandaan, Catherine Henshall, Sonia Serrano, Andrea Mazzella, Thurkka Rajeswaran, Moncy Mathew, Karen Bisnauthsing, Laura Bremner, Henry Fok, Franca Morselli, Paola Cinardo, Blair Merrick, Lucy Sowole, Samantha Broadhead, Natalie Palmer, Jessica Cordle, Jaimie Wilson Goldsmith, Enya Cooney, Beth Jackson, Thilina Jayatilleke, Zelda Cheng, Toby Helliwell, Adrian Chudyk, Rafaela Giemza, John Lord Villajin, Noah Yogo, Esther Makanju, Pearl Dulawan, Deepak Nagra, April Buazon, Alice Russell, Georgie Bird, Amardeep Heer, Rex Sarmiento, Balraj Sanghera, Melanie Mullin, Adam Champion, Aisling Bevan, Kinzah Iqbal, Alshia Johnson, Rebecca Clark, Sarah Shaw, Steven Shaw, Amanda Chalk, Martin Lovatt, Caroline Lillicrap, Angela Parker, Jan Hansel, Zhi Wong, Galvin Gan, Eyad Tuma, Jane Minton, Jennifer Murira, Razan Saman, Alistair Hall, Kyra Holliday, Zara Khan, James Calderwood, George Twigg, Helena Baker, Julie Corrigan, Katy Houseman, Subhra Raguvanshi, Dominic Heining, Jake Weddell, Liz Glaves, Kim Thompson, Francis Davies, Ruth Lambley Burke, Emma C. Thomson, Dinesh Saralaya, Lisa Berry, Nancy Hopewell, Leigh Gerdes, Mihaela Pacurar, Saul N. Faust, Jeremy Turner, Christopher Jeanes, Adele Cooper, Jocelyn Keshet-Price, Lou Coke, Melissa Cambell-Kelly, Ketan Dhatariya, Claire Williams, Georgina Marks, James Sudbury, Lisa Rodolico, Judy Bradley, Sharon Carr, Roisin Martin, Angelina Madden, Paul Biagioni, Sonia McKenna, Alison Clinton, Maurice O'Kane, Justin Carter, Matthew Dewhurst, Bill Wetherill, Thandiwe Hoggarth, Katrina Lennon Collins, Marie Chowdhury, Adil Nathoo, Anna Heinen, Orla MacDonald, Claudia Hurducas, Liliana Cifuentes, Harjeevan Gill, Andy Gibson, Raha West, Jane Ewing, Rachel Blacow, John Haughney, Jonathan MacDonald, John Paul Seenan, Stewart Webb, Colin O'Leary, Scott Muir, Beth White, Neil Ritchie, Daniel F. McAuley, Jonathan Stewart, Mariella D'Alessandro, Nicki Lakeman, Laura Purandare, Duncan Browne, David Tucker, Peter Luck, Angharad Everden, Lisa Trembath, Michael Visick, Nick Morley, Laura Reid, Helen Chenoweth, Kirsty Maclean, Ray P. Sheridan, Tom Burden, Craig Francis Lunt, Shirley Todd, Stephanie Estcourt, Jasmine Marie Pearce, Suzanne Wilkins, Cathryn Love-Rouse, Eva Torok-Pollok, Mike Youle, Sara Madge, Danielle Solomon, Aarti Nandani, Janet M. North, Nargis Hemat, Rachel Newport, Philip A. Kalra, Chukwuma Chukwu, Olivia Wickens, Vikki O'Loughlin, Hema Mistry, Louise Harrison, Robert Oliver, Anne-Marie Peers, Jess Zadik, Katie Doyle, David R. Chadwick, Kerry Colling, Caroline Wroe, Marie Branch, Alison Chilvers, Sarah Essex, Mark Stone, Alberto San Francisco Ramos, Emily Beales, Olivia Bird, Zsofia Danos, Hazel Fofie, Cecilia Hultin, Sabina Ikram, Fran Mabesa, Aoife Mescall, Josyanne Pereira, Jennifer Pearce, Natalina Sutton, Emma Snashall, David Neil Baxter, Sara Bennett, Debbie Suggitt, Kerry Hughes, Wiesia Woodyatt, Lynsey Beacon, Alissa Kent, Chris Cooper, Milan Rudic, Simon Tunstall, Matthew Jackson, Claire Hombersley, Patrick Moore, Rebecca Cutts, Andrew Higham, Marwan Bukhari, Mohamed Elnaggar, Michelle Glover, Fiona Richardson, Alexandra Dent, Shahzeb Mirza, Rajiv Ark, Jennie Han, Suzy V. Hope, Philip J. Mitchelmore, Rostam Osanlou, Andrew Freedman, Alison Cooper, Katherine Burton, Kashyap Katechia, Michael Barrett, Jo Salkeld, Natalie Hill, Nathaniel Lee, Jon Perkins, and Polly Fox
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Adult ,Pulmonary and Respiratory Medicine ,Trivalent influenza vaccine ,medicine.medical_specialty ,COVID-19 Vaccines ,Adolescent ,Influenza vaccine ,Population ,Placebo ,Young Adult ,Immunogenicity, Vaccine ,Double-Blind Method ,Internal medicine ,Humans ,Medicine ,education ,Adverse effect ,Aged ,education.field_of_study ,Reactogenicity ,SARS-CoV-2 ,business.industry ,COVID-19 ,Articles ,Middle Aged ,Vaccine efficacy ,Vaccination ,Influenza Vaccines ,Seasons ,business - Abstract
Background The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza vaccines have not yet been reported. We therefore aimed to report the results of a substudy within a phase 3 UK trial, by evaluating the safety, immunogenicity, and efficacy of NVX-CoV2373 when co-administered with licensed seasonal influenza vaccines. Methods We did a planned exploratory substudy as part of the randomised, observer-blinded, placebo-controlled, phase 3 trial of the safety and efficacy of the COVID-19 vaccine (NVX-CoV2373) by co-administrating the influenza vaccine at four study hospitals in the UK. Approximately, the first 400 participants meeting the main study entry criteria—with no contraindications to influenza vaccination—were invited to join the substudy. Participants of the main study were randomly assigned (1:1) to receive two intramuscular injections of either NVX-CoV2373 (5 μg) or placebo (normal saline) 21 days apart; participants enrolled into the substudy were co-vaccinated with a single (0·5 mL) intramuscular, age-appropriate (quadrivalent influenza cell-based vaccine [Flucelvax Quadrivalent; Seqirus UK, Maidenhead] for those aged 18–64 years and adjuvanted trivalent influenza vaccine [Fluad; Seqirus UK, Maidenhead] for those ≥65 years), licensed, influenza vaccine on the opposite deltoid to that of the first study vaccine dose or placebo. The influenza vaccine was administered in an open-label manner and at the same time as the first study injection. Reactogenicity was evaluated via an electronic diary for 7 days after vaccination in addition to monitoring for unsolicited adverse events, medically attended adverse events, and serious adverse events. Immunogenicity was assessed with influenza haemagglutination inhibition and SARS-CoV-2 anti-spike protein IgG assays. Vaccine efficacy against PCR-confirmed, symptomatic COVID-19 was assessed in participants who were seronegative at baseline, received both doses of study vaccine or placebo, had no major protocol deviations affecting the primary endpoint, and had no confirmed cases of symptomatic COVID-19 from the first dose until 6 days after the second dose (per-protocol efficacy population). Immunogenicity was assessed in participants who received scheduled two doses of study vaccine, had a baseline sample and at least one post-vaccination sample, and had no major protocol violations before unmasking (per-protocol immunogenicity population). Reactogenicity was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo and had data collected for reactogenicity events. Safety was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo. Comparisons were made between participants of the substudy and the main study (who were not co-vaccinated for influenza). This study is registered with ClinicalTrials.gov, number NCT04583995. Findings Between Sept 28, 2020, and Nov 28, 2020, a total of 15 187 participants were randomised into the main phase 3 trial, of whom 15 139 received treatment (7569 received dose one of NVX-CoV2373 and 7570 received dose one of placebo). 431 participants were co-vaccinated with a seasonal influenza vaccine in the substudy (217 received NVX-CoV2373 plus the influenza vaccine and 214 received placebo plus the influenza vaccine). In general, the substudy participants were younger, more racially diverse, and had fewer comorbid conditions than those in the main study. Reactogenicity events were more common in the co-administration group than in the NVX-CoV2373 alone group: tenderness (113 [64·9%] of 174 vs 592 [53·3%] of 1111) or pain (69 [39·7%] vs 325 [29·3%]) at injection site, fatigue (48 [27·7%] vs 215 [19·4%]), and muscle pain (49 [28·3%] vs 237 [21·4%]). Incidences of unsolicited adverse events, treatment-related medically attended adverse events, and serious adverse events were low and balanced between the co-administration group and the NVX-CoV2373 alone group. No episodes of anaphylaxis or deaths were reported within the substudy. Co-administration resulted in no change to influenza vaccine immune response although a reduction in antibody responses to the NVX-CoV2373 vaccine was noted. NVX-CoV2373 vaccine efficacy in the substudy (ie, participants aged 18 to
- Published
- 2022
6. Novel Oppositional Defiant Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents
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Jeffrey E. Max, Russell Schachar, John R. Hesselink, Florin Vaida, Daniel S Lowet, Tony T. Yang, Harvey S. Levin, Elisabeth A. Wilde, Sandra B. Chapman, Linda Ewing-Cobbs, Anish Kolan, Ann E. Saunders, Hattan Arif, Olga Tymofiyeva, and Erin D. Bigler
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Biopsychosocial model ,Adolescent ,Traumatic brain injury ,business.industry ,Not Otherwise Specified ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Psychiatric history ,Social Class ,Attention Deficit and Disruptive Behavior Disorders ,Conduct disorder ,Brain Injuries ,Child, Preschool ,Oppositional defiant ,Brain Injuries, Traumatic ,medicine ,Humans ,Neurology (clinical) ,Child ,business ,Psychosocial ,Socioeconomic status ,Clinical psychology - Abstract
Objective The investigators aimed to assess predictive factors of novel oppositional defiant disorder (ODD) among children and adolescents in the first 6 months following traumatic brain injury (TBI). Methods Children ages 5-14 years who experienced a TBI were recruited from consecutive admissions to five hospitals. Testing of a biopsychosocial model that may elucidate the development of novel ODD included assessment soon after injury (baseline) of preinjury characteristics, including psychiatric disorders, adaptive function, family function, psychosocial adversity, family psychiatric history, socioeconomic status, injury severity, and postinjury processing speed (which may be a proxy for brain injury). MRI analyses were also conducted to examine potential brain lesions. Psychiatric outcome, including that of novel ODD, was assessed 6 months after the injury. Results A total of 177 children and adolescents were recruited for the study, and 134 who were without preinjury ODD, conduct disorder, or disruptive behavior disorder not otherwise specified (DBD NOS) returned for the 6-month assessment. Of those who returned 6 months postinjury, 11 (8.2%) developed novel ODD, and none developed novel conduct disorder or DBD NOS. Novel ODD was significantly associated with socioeconomic status, preinjury family functioning, psychosocial adversity, and processing speed. Conclusions These findings show that an important minority of children with TBI developed ODD. Psychosocial and injury-related variables, including socioeconomic status, lower family function, psychosocial adversity, and processing speed, significantly increase risk for this outcome.
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- 2022
7. CDC LOCATe: discrepancies between self-reported level of maternal care and LOCATe-assessed level of maternal care among 463 birth facilities
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Jennifer L. Beauregard, M. Kathryn Menard, Alexander C. Ewing, Sabrina A. Madni, David A. Goodman, and Mary D. Brantley
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medicine.medical_specialty ,business.industry ,Family medicine ,Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology ,Medicine ,Obstetric ultrasound ,business ,Healthcare system - Abstract
OBJECTIVE Describe sources of discrepancy between self-assessed LoMC (level of maternal care) and CDC LOCATe®-assessed (Levels of Care Assessment Tool) LoMC. STUDY DESIGN CDC LOCATe® was implemented at 480 facilities in 13 jurisdictions, including states, territories, perinatal regions, and hospital systems, in the U.S. Cross-sectional analyses were conducted to compare facilities' self-reported LoMC and LOCATe®-assessed LoMC. RESULT Among 418 facilities that self-reported an LoMC, 41.4% self-reported a higher LoMC than their LOCATe®-assessed LoMC. Among facilities with discrepancies, the most common elements lacking to meet self-reported LoMC included availability of maternal-fetal medicine (27.7%), obstetric-specializing anesthesiologist (16.2%), and obstetric ultrasound services (12.1%). CONCLUSION Two in five facilities self-report a LoMC higher than their LOCATe®-assessed LoMC, indicating discrepancies between perceived maternal care capabilities and those recommended in current LoMC guidelines. Results highlight an opportunity for states to engage with facilities, health systems, and other stakeholders about LoMC and collaborate to strengthen systems for improving maternal care delivery.
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- 2021
8. Hypertension at delivery hospitalization – United States, 2016–2017
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Carla L. DeSisto, Cheryl L. Robbins, Jean Y. Ko, Alexander C. Ewing, Elena V. Kuklina, and Matthew D. Ritchey
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Adult ,medicine.medical_specialty ,Pregnancy ,Databases, Factual ,Pregnancy Associated Hypertension ,business.industry ,Obstetrics and Gynecology ,Hypertension, Pregnancy-Induced ,Delivery, Obstetric ,medicine.disease ,United States ,Hospitalization ,Hypertension ,Emergency medicine ,Prevalence ,Internal Medicine ,Hospital discharge ,medicine ,Humans ,Female ,Chronic hypertension ,business ,Healthcare Cost and Utilization Project ,Retrospective Studies - Abstract
In this study, hospital discharge data from the 2016–2017 Healthcare Cost and Utilization Project were analyzed to describe national and, where data were available, state-specific prevalences of chronic hypertension and pregnancy-associated hypertension at delivery hospitalization. In 2016–2017, the prevalence of chronic hypertension was 216 per 10,000 delivery hospitalizations nationwide, ranging from 125 to 400 per 10,000 delivery hospitalizations in individual states. The prevalence of pregnancy-associated hypertension was 1021 per 10,000 delivery hospitalizations nationwide, ranging from 693 to 1382 per 10,000 delivery hospitalizations in individual states. The burden of hypertensive disorders in pregnancy remains high and varies considerably by jurisdiction.
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- 2021
9. Thyroid-optimized and thyroid-sparing radiotherapy in oral cavity and oropharyngeal carcinoma: A dosimetric study
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Wesley Zoller, V.M. Diavolitsis, Ghazal Khandel, Eric D. Miller, M.Z. Kharouta, Jennifer A. Sipos, Dukagjin Blakaj, John C. Grecula, Jacob Eckstein, Ashlee Ewing, E. Healy, Jessica Wobb, Mauricio E. Gamez, Sachin R. Jhawar, Aashish D. Bhatt, Anna K. Wu, Stella Ling, N. Damico, Alok Deshane, and D.L. Mitchell
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medicine.medical_specialty ,endocrine system ,endocrine system diseases ,Intensity-modulated radiotherapy ,medicine.medical_treatment ,R895-920 ,Oral cavity ,Radiation toxicity ,Medical physics. Medical radiology. Nuclear medicine ,Hypothyroidism ,medicine ,Thyroid-sparing ,Radiology, Nuclear Medicine and imaging ,In patient ,Head and neck ,Care Planning ,Thyroid-optimized ,RC254-282 ,integumentary system ,Oncology (nursing) ,business.industry ,Health Policy ,Thyroid ,Cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Radiation therapy ,medicine.anatomical_structure ,Oropharyngeal Carcinoma ,Toxicity ,Radiology ,business ,therapeutics ,Research Article - Abstract
Highlights • This feasibility study showed thyroid sparing in head and neck cancer patients. • Thyroid sparing with acceptable target volume coverage was possible with IMRT. • Average mean dose to thyroid was significantly reduced with thyroid optimization. • Thyroid optimized plans had relatively unchanged doses to surrounding OARs., Background Radiation-induced hypothyroidism is a common toxicity of head and neck radiation. Our re-planning study aimed to reduce thyroid dose while maintaining target coverage with IMRT. Methods We retrospectively identified patients with oral-cavity (n = 5) and oropharyngeal cancer (n = 5). Treatment plans were re-optimized with 45 Gy thyroid mean dose constraint, then we cropped the thyroid out of PTVs and further reduced thyroid dose. Target coverage was delivering 100% dose to ≥ 93% of PTV and 95% of dose to > 99% of PTV. Results Originally, average mean dose to thyroid was 5580 cGy. In model I, this dropped to 4325 cGy (p
- Published
- 2021
10. Impact of Hospital Strain on Excess Deaths During the COVID-19 Pandemic — United States, July 2020–July 2021
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Moira Johnson, Marc Dion, Kaitlyn Webster, Maria Ewing, Josh Corman, Geoffrey French, Mary Hulse, Katharine Sobotka, Brago Aboagye-Nyame, Benjamin Zalinger, and Debbie Nguyen
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Adult ,medicine.medical_specialty ,Health (social science) ,Epidemiology ,Health, Toxicology and Mutagenesis ,Staffing ,Prevalence ,Psychological intervention ,law.invention ,Health Information Management ,law ,Environmental health ,Health care ,Pandemic ,Humans ,Medicine ,Full Report ,Mortality ,Pandemics ,Bed Occupancy ,business.industry ,Public health ,COVID-19 ,General Medicine ,Emergency department ,Intensive care unit ,Hospitals ,United States ,Intensive Care Units ,business - Abstract
Surges in COVID-19 cases have stressed hospital systems, negatively affected health care and public health infrastructures, and degraded national critical functions (1,2). Resource limitations, such as available hospital space, staffing, and supplies led some facilities to adopt crisis standards of care, the most extreme operating condition for hospitals, in which the focus of medical decision-making shifted from achieving the best outcomes for individual patients to addressing the immediate care needs of larger groups of patients (3). When hospitals deviated from conventional standards of care, many preventive and elective procedures were suspended, leading to the progression of serious conditions among some persons who would have benefitted from earlier diagnosis and intervention (4). During March-May 2020, U.S. emergency department visits declined by 23% for heart attacks, 20% for strokes, and 10% for diabetic emergencies (5). The Cybersecurity & Infrastructure Security Agency (CISA) COVID Task Force* examined the relationship between hospital strain and excess deaths during July 4, 2020-July 10, 2021, to assess the impact of COVID-19 surges on hospital system operations and potential effects on other critical infrastructure sectors and national critical functions. The study period included the months during which the highly transmissible SARS-CoV-2 B.1.617.2 (Delta) variant became predominant in the United States.† The negative binomial regression model used to calculate estimated deaths predicted that, if intensive care unit (ICU) bed use nationwide reached 75% capacity an estimated 12,000 additional excess deaths would occur nationally over the next 2 weeks. As hospitals exceed 100% ICU bed capacity, 80,000 excess deaths would be expected in the following 2 weeks. This analysis indicates the importance of controlling case growth and subsequent hospitalizations before severe strain. State, local, tribal, and territorial leaders could evaluate ways to reduce strain on public health and health care infrastructures, including implementing interventions to reduce overall disease prevalence such as vaccination and other prevention strategies, as well as ways to expand or enhance capacity during times of high disease prevalence.
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- 2021
11. Spectral Considerations for Standoff Infrared Detection of RDX on Reflective Aluminum
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Kevin J. Major, Mikella E. Farrell, Ellen L. Holthoff, Paul M. Pellegrino, Jasbinder S. Sanghera, and Kenneth J. Ewing
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Materials science ,Optics ,Explosive material ,chemistry ,Infrared ,Aluminium ,business.industry ,chemistry.chemical_element ,Specular reflection ,Diffuse reflection ,business ,Instrumentation ,Spectroscopy - Abstract
This paper examines infrared spectroscopic effects for the standoff detection of an explosive material, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), inkjet printed on an aluminum surface. Results of a spectroscopic study are described, using multiple optical setups. These setups were selected to explore how variations in the angles of incidence and collection from the surface of the material result in corresponding variations in the spectral signatures. The goal of these studies is to provide an understanding of these spectral changes since it affects standoff detection of hazardous materials on a reflective substrate. We demonstrate that variations in spectral effects are dependent on the relative surface concentration of the deposited RDX. We also show that it is reasonable to use spectroscopic data collected in a standard laboratory infrared spectrometer outfitted with a variable angle reflectometer set at 0° as reference spectra for data collected in a standoff configuration. These results are important to provide a systematic approach to understanding infrared (IR) spectra collection using standoff systems in the field, and to allow for comparison between such data, and data collected in the laboratory. Although the precise results are constrained to a specific material system (thin layers on a reflective substrate), the approach and general discussion provided are applicable to a broad range of IR standoff sensing techniques and applications.
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- 2021
12. Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial
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Denise M. Wolf, Jane Perlmutter, Judy C. Boughey, A. Jo Chien, Meredith Buxton, Gillian L. Hirst, Douglas Yee, Angela DeMichele, Andres Forero-Torres, Scott M. Berry, Erin D. Ellis, Anthony D. Elias, Julia Wulfkuhle, Michael Alvarado, Christina Yau, Stacy L. Moulder, Nola M. Hylton, Rita Nanda, Amy Wilson, Adam Asare, Debu Tripathy, Claudine Isaacs, Melissa Paoloni, Rosa I. Gallagher, Laura J. Esserman, Richard Schwab, W. Fraser Symmans, Cheryl Ewing, Laura J. van't Veer, Jeffrey B. Matthews, Teresa Helsten, Julia L. Clennell, Barbara Haley, Emanuel F. Petricoin, Katherine Steeg, Smita Asare, Ashish Sanil, Rachel L. Yung, Erin P. Crane, Erin Roesch, Hyo S. Han, Ruby Singhrao, Michelle E. Melisko, Hope S. Rugo, Kathy S. Albain, Donald A. Berry, Anne M. Wallace, Julie E. Lang, Amy S. Clark, Kathleen Kemmer, and Lamorna Brown-Swigart
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Oncology ,Receptor, ErbB-2 ,General Physics and Astronomy ,Ado-Trastuzumab Emtansine ,chemistry.chemical_compound ,Breast cancer ,ErbB-2 ,Trastuzumab ,Monoclonal ,skin and connective tissue diseases ,Humanized ,Cancer ,Multidisciplinary ,Tumor ,medicine.diagnostic_test ,Middle Aged ,Neoadjuvant Therapy ,Paclitaxel ,6.1 Pharmaceuticals ,Pertuzumab ,medicine.drug ,Receptor ,Adult ,medicine.medical_specialty ,Cyclophosphamide ,Science ,Clinical Trials and Supportive Activities ,Context (language use) ,Breast Neoplasms ,Antibodies, Monoclonal, Humanized ,Article ,General Biochemistry, Genetics and Molecular Biology ,Antibodies ,Clinical Research ,Internal medicine ,Biopsy ,Breast Cancer ,Biomarkers, Tumor ,medicine ,Humans ,Doxorubicin ,Maytansine ,neoplasms ,Aged ,business.industry ,Evaluation of treatments and therapeutic interventions ,General Chemistry ,Translational research ,medicine.disease ,chemistry ,business ,Biomarkers - Abstract
HER2-targeted therapy dramatically improves outcomes in early breast cancer. Here we report the results of two HER2-targeted combinations in the neoadjuvant I-SPY2 phase 2 adaptive platform trial for early breast cancer at high risk of recurrence: ado-trastuzumab emtansine plus pertuzumab (T-DM1/P) and paclitaxel, trastuzumab and pertuzumab (THP). Eligible women have >2.5 cm clinical stage II/III HER2+ breast cancer, adaptively randomized to T-DM1/P, THP, or a common control arm of paclitaxel/trastuzumab (TH), followed by doxorubicin/cyclophosphamide, then surgery. Both T-DM1/P and THP arms ‘graduate’ in all subtypes: predicted pCR rates are 63%, 72% and 33% for T-DM1/P (n = 52), THP (n = 45) and TH (n = 31) respectively. Toxicity burden is similar between arms. Degree of HER2 pathway signaling and phosphorylation in pretreatment biopsy specimens are associated with response to both T-DM1/P and THP and can further identify highly responsive HER2+ tumors to HER2-directed therapy. This may help identify patients who can safely de-escalate cytotoxic chemotherapy without compromising excellent outcome., HER2-targeted therapy improves patient’s outcome in early breast cancer. Here, the authors present the efficacy and biomarker analysis of two HER2-targeted combinations (ado-trastuzumab emtansine plus pertuzumab and paclitaxel, trastuzumab and pertuzumab) in the context of the neoadjuvant I-SPY2 phase 2 adaptive platform trial for early breast cancer at high risk of recurrence.
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- 2021
13. Randomized Community Trial Comparing Telephone versus Clinic‐Based Behavioral Health Counseling for People Living with HIV in a Rural Setting
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Wendy Ewing, Lisa A. Eaton, Harold P. Katner, Marnie Hill, Moira O. Kalichman, and Seth C. Kalichman
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Counseling ,Rural Population ,medicine.medical_specialty ,business.industry ,Rural health ,Nutrition Education ,Medical record ,Public Health, Environmental and Occupational Health ,HIV Infections ,Telehealth ,Medication Adherence ,Telephone ,Discontinuation ,Telephone counseling ,Pill ,Family medicine ,Intervention (counseling) ,medicine ,Humans ,business - Abstract
Purpose To test the efficacy of a theory-based behavioral intervention delivered via telephone versus clinic-based counseling to improve HIV outcomes and reduce alcohol consumption for people at-risk for treatment failure in a rural setting. Methods Patients receiving HIV care (N = 240) were randomized using a computer-generated scheme to one of three conditions: (a) telephone behavioral health counseling, (b) clinic-based behavioral health counseling, or (c) attention control nutrition education. Behavioral counseling was delivered by either a community nurse or a paraprofessional patient navigator, with differences examined. Participants were followed for 12 months to assess medication adherence using unannounced pill counts and alcohol use measured by electronic daily text message assessments, and 18 months for HIV viral load and retention in care extracted from medical records. Findings There was evidence for telephone and office-based counseling demonstrating greater medication adherence than the control condition but only in the short term. Clinic-based behavioral counseling significantly reduced alcohol use to a greater degree than telephone counseling and the control condition. There were no other differences between conditions. There were also no discernable differences between counseling delivered by the community nurse and the patient navigator. Conclusions Telephone and clinic-based counseling demonstrated improved medication adherence in the short term, while clinic-based counseling demonstrated reductions in alcohol use. The modest outcomes suggest that intensive intervention strategies are needed for patients that clinicians identify as at-risk for treatment discontinuation and treatment failure.
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- 2021
14. The B‐APNEIC score: distilling the STOP‐Bang questionnaire to identify patients at high risk for severe obstructive sleep apnoea
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Ruben J. Azocar, Sadeq A. Quraishi, S. Ewing, R. Morinigo, and R. Schumann
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Adult ,Male ,Neck circumference ,Pediatrics ,medicine.medical_specialty ,Polysomnography ,Logistic regression ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,Stop bang ,Prospective Studies ,Aged ,Sleep Apnea, Obstructive ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Patient Acuity ,Middle Aged ,Sleep in non-human animals ,respiratory tract diseases ,Anesthesiology and Pain Medicine ,Blood pressure ,Female ,business ,Body mass index - Abstract
The STOP-Bang questionnaire is an established clinical screening tool to identify the risk of having mild, moderate or severe obstructive sleep apnoea using eight variables. It is unclear whether all eight variables contribute equally to the risk of clinically significant obstructive sleep apnoea. We analysed each variable for its contribution to detecting obstructive sleep apnoea; based on the results, we investigated whether the STOP-Bang questionnaire could be abbreviated to identify patients at high risk for severe obstructive sleep apnoea. We recruited patients with suspected obstructive sleep apnoea who were referred for overnight polysomnography. We used multivariable logistic regression to investigate the association of STOP-Bang parameters with severe obstructive sleep apnoea based on clinical and polysomnography data. Regression estimates were used to select variables to create the novel B-APNEIC score. We constructed receiver operating characteristic curves for the STOP-Bang questionnaire and B-APNEIC scores to identify patients with severe obstructive sleep apnoea and compared the areas under the curve using the DeLong method. Of the 275 patients enrolled, 32% (n = 88) had severe obstructive sleep apnoea. Logistic regression demonstrated that neck circumference (OR 2.20; 95%CI 1.10-4.40, p = 0.03) was the only variable independently associated with severe obstructive sleep apnoea. Observed apnoea during sleep, blood pressure and body mass index were the three next most closely trending predictors of severe obstructive sleep apnoea and were included along with neck circumference in the B-APNEIC score. Receiver operating curves demonstrated that the areas under the curve for STOP-Bang vs. B-APNEIC were comparable for identifying patients with severe obstructive sleep apnoea (OR 0.75; 95%CI 0.68-0.81 vs. OR 0.75; 95%CI 0.68-0.81: p = 0.99, respectively). Our results suggest that the B-APNEIC score is a simplified adaptation of the STOP-Bang questionnaire with equivalent effectiveness in identifying patients with severe obstructive sleep apnoea. Further studies are needed to validate and build on our findings.
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- 2021
15. 'I'm fine!': Assertions of lack of support need among patients with chronic obstructive pulmonary disease: A mixed-methods study
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Efthalia Massou, Morag Farquhar, A Carole Gardener, Gail Ewing, Robbie Duschinsky, Caroline Moore, Gardener, A Carole [0000-0002-8064-3780], and Apollo - University of Cambridge Repository
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medicine.medical_specialty ,Chronic Obstructive Pulmonary Disease ,Pulmonary disease ,compliance ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Longitudinal Studies ,Stage (cooking) ,Intensive care medicine ,disavowal ,COPD ,030504 nursing ,business.industry ,Health Policy ,help-seeking ,Palliative Care ,General Medicine ,Focus Groups ,medicine.disease ,Help-seeking ,Self Report ,support needs ,0305 other medical science ,business - Abstract
Funder: Marie Curie; FundRef: https://doi.org/10.13039/501100000654, OBJECTIVES: To understand how people with Chronic Obstructive Pulmonary Disease (COPD) disavow their support needs and the impact on care. METHODS: Two stage mixed-method design. Stage 1 involved sub-analyses of data from a mixed-method population-based longitudinal study exploring the needs of patients with advanced COPD. Using adapted criteria from mental health research, we identified 21 patients who disavowed their needs from the 235 patient cohort. Qualitative interview transcripts and self-report measures were analysed to compare these patients with the remaining cohort. In stage 2 focus groups (n = 2) with primary healthcare practitioners (n = 9) explored the implications of Stage 1 findings. RESULTS: Patients who disavowed their support needs described non-compliance with symptom management and avoidance of future care planning (qualitative data). Analysis of self-report measures of mental and physical health found this group reported fewer needs than the remaining sample yet wanted more GP contact. The link between risk factors and healthcare professional involvement present in the rest of the sample was missing for these patients. Focus group data suggested practitioners found these patients challenging. DISCUSSION: This study identified patients with COPD who disavow their support needs, but who also desire more GP contact. GPs report finding these patients challenging to engage.
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- 2022
16. Accessible, affordable, fine‐scale estimates of soil carbon for sustainable management in sub‐Saharan Africa
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Sieglinde S. Snapp, Dan TerAvest, Patrick M. Ewing, and Xinyi Tu
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Sub saharan ,Scale (ratio) ,business.industry ,Sustainable management ,Environmental resource management ,Soil Science ,Environmental science ,Soil carbon ,business - Published
- 2021
17. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration
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Graeme J. Hankey, Maree L. Hackett, Osvaldo P. Almeida, Leon Flicker, Gillian E. Mead, Martin S. Dennis, Christopher Etherton-Beer, Andrew H. Ford, Laurent Billot, Stephen Jan, Thomas Lung, Erik Lundström, Katharina S. Sunnerhagen, Craig S. Anderson, Huy Thang-Nguyen, John Gommans, Qilong Yi, Veronica Murray, Robert Herbert, Gregory Carter, Geoffrey A. Donnan, Huy-Thang Nguyen, Qiang Li, Severine Bompoint, Sarah Barrett, Anne Claxton, Julia O’Dea, Michelle Tang, Clare Williams, Shenae Peterson, Christie Drummond, Uyen-Ha Hong, Linh-Thi My Le, Tram-Thi Bich Ngo, Yen-Bao Mai, Huyen-Thanh Han, Nhu-Quynh Truong, Huong-Thi Nguyen, Hai-Thanh Ngo, Thi Binh Nguyen, Oanh-Thi Kieu Ha, Trang-Le Huyen Nguyen, Richard I. Lindley, Peter New, Andrew Lee, Thanh-Trung Tran, Loan-Tran Truc Mai Le, Thuy-Le Vu Kieu, Sang-Van Nguyen, Thuy-Anh Diem Nguyen, Tam-Nhat Dang, Hanh-Thi Truc Phan, Loan-Thi Ngoc Vo, Mai-Hue Nguyen, Hanh-Cao Dang, Hong-Thi Tran, Linh-Thi Cam Dam, Trinh-Thi Kim Ngo, Thai-Nguyen Thanh Pham, Binh-Nguyen Pham, Nha-Thi Thanh Dao, Huong-Thi Bich Nguyen, Linh-Thi Cam Le, Chi-Minh Do, Huy-Quoc Huynh, Giau-Thi Kim Tran, Oanh-Thi Le, Ly-Thi Khanh Tran, Chinh-Dinh Duong, Duong-Van Kieu, Na Le, Hoa-Ngoc Nguyen, Binh-Van Le, Long-Thanh Nguyen, Long-Van Nguyen, Tuan-Quoc Dinh, Tan-Van Vo, Tram-Ngoc Bui, Uyen-Thi To Hoang, Hien-Thi Bich Nguyen, Ha-Thi Thu Nguyen, Nga-Thuy Lam, Khanh-Kim Le, Phuong-Thanh Trinh, Hop-Quang Huynh, Thao-Thi Thu Nguyen, Huyen-Ngoc Lu, Tham-Hong Pham, Sam-Hoanh Nguyen, Ninh-Hong Le, Giang-Truong Nguyen, Bich-Thi Doan, Sung-Phuoc Pham, Duong-Huu Luong, Ha-Van Mai, Thuc-Van Tran, Phuong-Thi Do, Hoai-Thi Le, Chi-Van Nguyen, Phuong-Doan Nguyen, Ton-Duy Mai, Phuong-Viet Dao, Dung-Tien Nguyen, Dai-Quoc Khuong, Trung-Xuan Vuong, Lan-Tuong Vu, Ngoc-Duc Ngo, Hanh-Hong Dang, Phuong-Thai Truong, Ngan-Thi Le, Hoa-Van Hoang, Chung-Quang Do, Minh-Thao Nguyen, Anh-Hai Dam, Quynh-Nhu Le, Ngoc-Hoang Nguyen, Tuyen-Van Nguyen, Toan-Dinh Le, Ha-Thi Hai Dinh, Cuong–Van Pham, Khanh-Thi Ngoc Thach, Linh-Hai Nguyen, Loan-Thi Nguyen, Vien-Chi Le, Phuong-Hong Tran, Tai-Anh Nguyen, Tuan-Van Le, Luyen-Van Truong, Tue-Chau Bui, Ngoc-Xuan Huynh, Lap-Van Dinh, An-Gia Pham, Trang-Thi Huyen Le, Vy-Tuong Nguyen, Yen-Hai Nguyen, Thang-Ba Nguyen, Huy Thai, Quyen-Thi Ngoc Pham, Khoa-Duy Dao, Quoc-Nguyen Bao Pham, Thuong-Thi Huyen Dang, Huong-Huynh To Dinh, Trang-Mai Tong, Thuy-Thi Vu, Si-Tri Le, Tai-Ngoc Tran, Phuong-Hoai Tran, Ngoc-Thuy Nhu Dinh, Binh-Thanh Nguyen, Vinh-Phuong Do, Anh-Ngoc Nguyen, Binh-Thi Thanh Nguyen, David Blacker, Lindsey Bunce, Ai Ling Tan, Darshan Ghia, Gillian Edmonds, Nicole O’Loughlin, Megan Ewing, Kerri-Ann Whittaker, Lorralee Deane, Yash Gawarikar, Brett Jones, Maria Lopez, Koushik Nagesh, Emma Siracusa, Stephen Davis, Amy McDonald, Jess Tsoleridis, Rachael McCoy, David Jackson, Gab Silver, Timothy R. Bates, Amanda Boudville, Lynda Southwell, Dennis Cordato, Alan J. McDougall, Cecilia Cappelen-Smith, Zeljka Calic, Shabeel Askar, Qi Cheng, Raymond Kumar, Richard Geraghty, Maree Duroux, Megan Ratcliffe, Samantha Shone, Cassandra McLennan, Ramesh Sahathevan, Casey Hair, Stanley Levy, Beverley Macdonald, Benjamin Nham, Louise Rigney, Dev Nathani, Sumana Gopinath, Vishal Patel, Abul Mamun, Benjamin Trewin, Chun Phua, Ho Choong, Lauren Tarrant, Kerry Boyle, Luisa Hewitt, Monique Hourn, Amanda Masterson, Kim Oakley, Karen Ruddell, Colette Sanctuary, Kimberley Veitch, Camelia Burdusel, Lina Lee, Gary Cheuk, Jeremy Christley, Tabitha Hartwell, Craig Davenport, Kate Hickey, Rosanna Robertson, Michelle Carr, Sam Akbari, Hannah Coyle, Megan O’Neill, Cameron Redpath, Caroline Roberts, Marjan Tabesh, Toni Withiel, Kapila Abeysuriya, Andrew Granger, Angela Abraham, Chermaine Chua, Dung Do Nguyen, Vathani Surendran, Melissa Daines, David Shivlal, Mudassar Latif, Noreen Mughal, Patricia Morgan, Martin Krause, Miriam Priglinger, Ehsan E. Shandiz, Susan Day, Lay Kho, Michael Pollack, Judith Dunne, Helen Baines, Merridie Rees, Jenni White, Aicuratiya Withanage, Candice Delcourt, Cheryl Carcel, Alejandra Malavera, Amy Kunchok, Elizabeth Ray, Elizabeth Pepper, Emily Duckett, Sally Ormond, Andrew Moey, Timothy Kleinig, Vanessa Maxwell, Chantal Baldwin, Wilson Vallat, Deborah Field, Romesh Markus, Kirsty Page, Danielle Wheelwright, Sam Bolitho, Steven Faux, Fix Sangvatanakul, Alexis Brown, Susan Walker, Jennifer Massey, Hillary Hayes, Pesi Katrak, Annie Winker, Alessandro Zagami, Alanah Bailey, Sarah Mccormack, Andrew Murray, Mark Rollason, Christopher Taylor, Fintan O’Rourke, Ye Min Kuang, Heike Burnet, Yvonne Liu, Aileen Wu, Diana Ramirez, Tissa Wijeratne, Sherisse Celestino, Essie Low, Cynthia Chen, Jennifer Bergqvist, Andrew Evans, Queenie Leung, Martin Jude, Rachael McQueen, Katherine Mohr, Latitia Kernaghan, Paul Stockle, Boon L. Tan, Sara Laubscher, Diana Schmid, Melissa Spooner, Bhavesh Lallu, Bronwen Pepperell, John Chalissery, Karim Mahawish, Susan DeCaigney, Paula Broughton, Karen Knight, Veronica Duque, Harry McNaughton, Jeremy Lanford, Vivian Fu, and Lai-Kin Wong
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Male ,medicine.medical_specialty ,Steering committee ,medicine.medical_treatment ,Placebo ,B700 ,Fractures, Bone ,Cognition ,Double-Blind Method ,Recurrence ,Seizures ,Fluoxetine ,Internal medicine ,Humans ,Medicine ,Stroke ,Fatigue ,Aged ,Ischemic Stroke ,Acute stroke ,Advanced and Specialized Nursing ,business.industry ,Recovery of Function ,Middle Aged ,Functional recovery ,medicine.disease ,Clinical trial ,Affect ,Hemorrhagic Stroke ,Quality of Life ,Accidental Falls ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Stroke recovery ,Selective Serotonin Reuptake Inhibitors ,medicine.drug - Abstract
Background and Purpose: The AFFINITY trial (Assessment of Fluoxetine in Stroke Recovery) reported that oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and seizures. After trial medication was ceased at 6 months, survivors were followed to 12 months post-randomization. This preplanned secondary analysis aimed to determine any sustained or delayed effects of fluoxetine at 12 months post-randomization. Methods: AFFINITY was a randomized, parallel-group, double-blind, placebo-controlled trial in adults (n=1280) with a clinical diagnosis of stroke in the previous 2 to 15 days and persisting neurological deficit who were recruited at 43 hospital stroke units in Australia (n=29), New Zealand (4), and Vietnam (10) between 2013 and 2019. Participants were randomized to oral fluoxetine 20 mg once daily (n=642) or matching placebo (n=638) for 6 months and followed until 12 months after randomization. The primary outcome was function, measured by the modified Rankin Scale, at 6 months. Secondary outcomes for these analyses included measures of the modified Rankin Scale, mood, cognition, overall health status, fatigue, health-related quality of life, and safety at 12 months. Results: Adherence to trial medication was for a mean 167 (SD 48) days and similar between randomized groups. At 12 months, the distribution of modified Rankin Scale categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio, 0.93 [95% CI, 0.76–1.14]; P =0.46). Compared with placebo, patients allocated fluoxetine had fewer recurrent ischemic strokes (14 [2.18%] versus 29 [4.55%]; P =0.02), and no longer had significantly more falls (27 [4.21%] versus 15 [2.35%]; P =0.08), bone fractures (23 [3.58%] versus 11 [1.72%]; P =0.05), or seizures (11 [1.71%] versus 8 [1.25%]; P =0.64) at 12 months. Conclusions: Fluoxetine 20 mg daily for 6 months after acute stroke had no delayed or sustained effect on functional outcome, falls, bone fractures, or seizures at 12 months poststroke. The lower rate of recurrent ischemic stroke in the fluoxetine group is most likely a chance finding. Registration: URL: http://www.anzctr.org.au/ ; Unique identifier: ACTRN12611000774921.
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- 2021
18. FSH Level and Changes in Bone Mass and Body Composition in Older Women and Men
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Vilmundur Guðnason, Ann V. Schwartz, Trisha F. Hue, Sigurður Sigurðsson, Clifford J. Rosen, Annegreet G Veldhuis-Vlug, Xiaojuan Li, Anne L. Schafer, Mone Zaidi, Thomas Lang, Gina N Woods, Deborah M. Kado, Susan K. Ewing, Karin C. Wu, Tiffany Y. Kim, and Eric Vittinghoff
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Male ,0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,030209 endocrinology & metabolism ,Context (language use) ,Biochemistry ,Bone remodeling ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Endocrinology ,Bone Density ,Internal medicine ,medicine ,Humans ,Quantitative computed tomography ,Testosterone ,Femoral neck ,Aged, 80 and over ,Bone mineral ,Clinical Research Article ,medicine.diagnostic_test ,Femur Neck ,business.industry ,Biochemistry (medical) ,Bone Diseases, Metabolic ,030104 developmental biology ,medicine.anatomical_structure ,Adipose Tissue ,Cohort ,Body Composition ,Female ,Composition (visual arts) ,Follicle Stimulating Hormone ,business - Abstract
Context FSH may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes. Objective We examined whether baseline FSH level is associated with subsequent bone loss or body composition changes in older adults. Setting, Design, Participants We studied 162 women and 158 men (mean age 82 ± 4 years) from the Age, Gene/Environment Susceptibility (AGES)-Bone Marrow Adiposity cohort, a substudy of the AGES-Reykjavik Study of community-dwelling older adults. Skeletal health and body composition were characterized at baseline and 3 years later. Main Outcomes Annualized change in BMD and body composition by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Models were adjusted for serum estradiol and testosterone levels. Results There was no evidence for an association between baseline FSH level and change in BMD or body composition by DXA or QCT. For femoral neck areal BMD, adjusted mean difference (95% CI) per SD increase in FSH was 1.3 (-0.7 to 3.3) mg/cm2/y in women, and -0.2 (-2.6 to 2.2) mg/cm2/y in men. For visceral fat, adjusted mean difference (95% CI) per SD increase in FSH was 1.80 (-0.03 to 3.62) cm2/y in women, and -0.33 (-3.73 to 3.06) cm2/y in men. Conclusions Although cross-sectional studies and studies in perimenopausal women have demonstrated associations between FSH and BMD and body composition, in older adults, FSH level is not associated with bone mass or body composition changes.
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- 2021
19. SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study
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Daniel Stadlbauer, Hua Wei Chen, Peifang Sun, Ernesto Santa Ana, Russell P. Tracy, Stuart C. Sealfon, Sagie Mofsowitz, Dawn L. Weir, Megan A. Schilling, Venugopalan D. Nair, Florian Krammer, Jan Marayag, William D. Graham, Yongchao Ge, Rhonda A. Lizewski, Daniel Ewing, Edgar Nunez, Mary Catherine George, Alexander Bukreyev, Andrew G. Letizia, Preeti Bharaj, Natalia Kuzmina, Nada Marjanovic, Chad K. Porter, Franca R. Jones, Sindhu Vangeti, Alessandra Soares-Schanoski, Clare M. Miller, Irene Ramos, Michael Termini, Carl Goforth, Corey A. Balinsky, Danielle M. Parent, Stephen E. Lizewski, and Victor A. Sugiharto
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Rate ratio ,law.invention ,Serology ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,Quarantine ,medicine ,Humans ,Medical history ,030212 general & internal medicine ,Young adult ,Prospective cohort study ,SARS-CoV-2 ,business.industry ,COVID-19 ,Articles ,Virus Shedding ,030228 respiratory system ,Reinfection ,business ,Risk assessment ,Cohort study - Abstract
Background Whether young adults who are infected with SARS-CoV-2 are at risk of subsequent infection is uncertain. We investigated the risk of subsequent SARS-CoV-2 infection among young adults seropositive for a previous infection. Methods This analysis was performed as part of the prospective COVID-19 Health Action Response for Marines study (CHARM). CHARM included predominantly male US Marine recruits, aged 18–20 years, following a 2-week unsupervised quarantine at home. After the home quarantine period, upon arrival at a Marine-supervised 2-week quarantine facility (college campus or hotel), participants were enrolled and were assessed for baseline SARS-CoV-2 IgG seropositivity, defined as a dilution of 1:150 or more on receptor-binding domain and full-length spike protein ELISA. Participants also completed a questionnaire consisting of demographic information, risk factors, reporting of 14 specific COVID-19-related symptoms or any other unspecified symptom, and brief medical history. SARS-CoV-2 infection was assessed by PCR at weeks 0, 1, and 2 of quarantine and participants completed a follow-up questionnaire, which included questions about the same COVID-19-related symptoms since the last study visit. Participants were excluded at this stage if they had a positive PCR test during quarantine. Participants who had three negative swab PCR results during quarantine and a baseline serum serology test at the beginning of the supervised quarantine that identified them as seronegative or seropositive for SARS-CoV-2 then went on to basic training at Marine Corps Recruit Depot—Parris Island. Three PCR tests were done at weeks 2, 4, and 6 in both seropositive and seronegative groups, along with the follow-up symptom questionnaire and baseline neutralising antibody titres on all subsequently infected seropositive and selected seropositive uninfected participants (prospective study period). Findings Between May 11, 2020, and Nov 2, 2020, we enrolled 3249 participants, of whom 3168 (98%) continued into the 2-week quarantine period. 3076 (95%) participants, 2825 (92%) of whom were men, were then followed up during the prospective study period after quarantine for 6 weeks. Among 189 seropositive participants, 19 (10%) had at least one positive PCR test for SARS-CoV-2 during the 6-week follow-up (1·1 cases per person-year). In contrast, 1079 (48%) of 2247 seronegative participants tested positive (6·2 cases per person-year). The incidence rate ratio was 0·18 (95% CI 0·11–0·28; p
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- 2021
20. HIV stigma experiences and alcohol use among patients receiving medical care in the rural south
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Wendy Ewing, Harold P. Katner, Renee El-Krab, Moira O. Kalichman, Marnie Hill, and Seth C. Kalichman
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chemistry.chemical_compound ,medicine.medical_specialty ,chemistry ,business.industry ,Family medicine ,medicine ,General Earth and Planetary Sciences ,Alcohol ,business ,Medical care ,General Environmental Science ,Hiv stigma - Published
- 2021
21. A Survey of Multimodal Sensor Fusion for Passive RF and EO Information Integration
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Robert L. Ewing, Peter Zulch, Jenny Liu, Erik Blasch, Asad Vakil, and Jia Li
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Artificial neural network ,Computer science ,business.industry ,Machine vision ,Digital imaging ,Aerospace Engineering ,Sensor fusion ,Space and Planetary Science ,Feature (computer vision) ,Histogram ,Computer vision ,Radio frequency ,Artificial intelligence ,Electrical and Electronic Engineering ,business ,Information integration - Abstract
Integrating information collected by different types of sensors observing the same or related phenomenon can lead to more accurate and robust decision making. The purpose of this article is to review sensor fusion approaches to achieve passive radio frequency (RF) and electro-optical (EO) sensor fusion and to present the proposed fusion of EO/RF neural network (FERNN). While research has been conducted to integrate complementary data collected by EO and RF modalities, the processing of RF data usually applies traditional features, such as Doppler. This article explores the viability of using the histogram of I/Q (in-phase and quadrature) data for the purposes of augmenting the detection accuracy that EO input alone is incapable of achieving. Specifically, by processing the histogram of I/Q data via deep learning and enhancing feature input for neural network fusion. Using the simulated data from the Digital Imaging and Remote Sensing Image Generation dataset, FERNN can achieve 95% accuracy in vehicle detection and scenario categorization, which is a 23% improvement over the accuracy achieved by a stand-alone EO sensor.
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- 2021
22. A Single-Center Retrospective Review of Perioperative Complications and Reoperation Rates Between Open Cranial Vault Remodeling and Distraction Osteogenesis for Unilateral Coronal Craniosynostosis
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Rachel M Segal, George N. Kamel, Alvin Wong, Emily Ewing, Michael Hornacek, Samuel Lance, Amanda A. Gosman, and Mary Kristine Carbulido
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Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Osteogenesis, Distraction ,Single Center ,Craniosynostosis ,Craniosynostoses ,Cranial vault ,medicine ,Humans ,Retrospective Studies ,Retrospective review ,business.industry ,Skull ,Infant ,General Medicine ,Perioperative ,Unilateral coronal craniosynostosis ,medicine.disease ,Surgery ,Treatment Outcome ,Otorhinolaryngology ,Cohort ,Distraction osteogenesis ,business - Abstract
Background Unilateral coronal craniosynostosis (UCS) is the third most prevalent form of craniosynostosis. Traditional treatment of UCS has been achieved with fronto-orbital advancement and cranial vault remodeling (FOAR), but utilization of cranial distraction osteogenesis (DO) techniques has increased. This study aims to compare perioperative complications and reoperation trends in FOAR versus DO techniques at a single institution. Methods An Institutional Review Board-approved retrospective review was performed from January 1999 to November 2018 at a single institution. Patients were those that have undergone FOAR or DO with an anterior rotational flap technique as previously described. Indications for secondary procedures included: contour deformities, relapse, surgical site infection, and persistent cranial defects. Results Eighty-one patients with UCS were identified, 64 patients underwent FOAR and 17 patients underwent DO. When perioperative characteristics were compared, patients who underwent DO were younger in age, however, there was no significant difference in transfusion requirement or length of stay between patient cohorts. Surgery time was increased in DO patients. When perioperative complications were compared, more intraoperative dural tears were observed in the FOAR cohort. When unplanned reoperation rates were compared, patients who had undergone FOAR had a statistically significant higher reoperation rates at 5 years of follow up. When including routine distractor removal as a reoperation, reoperative rate was increased in the DO cohort. No difference in reoperation rates was noted at 5 years following index operation. Conclusions The safety profile of DO is similar to that of traditional FOAR techniques for treatment of UCS. Longer-term follow-up studies are needed to elucidate whether outcomes are durable, but the unplanned reoperation rate in DO is less than that of FOAR at 5 years and presents several advantages that warrants its use in patients with UCS.
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- 2021
23. Floating on a Chemical Sea
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Samuel Dylan Ewing
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Cultural Studies ,Color film ,Engineering ,Visual Arts and Performing Arts ,business.industry ,Computer graphics (images) ,Launched ,business - Abstract
When the Polaroid Corporation launched the now-iconic SX-70 system in 1972, it represented a series of technological breakthroughs. The color film developed automatically, and the collapsible camer...
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- 2021
24. Open data from the first and second observing runs of advanced LIGO and advanced Virgo
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Rich , Abbott, Thomas , Sheelu , Abraham, Fausto , Acernese, Kendall , Ackley, Carl , Adams, Rana , Adhikari, Vaishali , Adya, Christoph , Affeldt, Michalis , Agathos, Kazuhiro , Agatsuma, Nancy , Aggarwal, Odylio , Aguiar, Amit , Aich, Lorenzo , Aiello, Anirban , Ain, Ajith , Parameswaran, Gabrielle , Allen, Annalisa , Allocca, Paul , Altin, Alex , Amato, Shreya , Anand, Alena , Ananyeva, Stuart , Anderson, Warren , Svetoslava, Angelova, Stefano , Ansoldi, Sarah , Antier, Stephen , Appert, Koji , Arai, Melody, Araya, Joseph, Areeda, Marc , Arène, Nicolas , Arnaud, Scott, Aronson, Arun, Kg, Ascenzi, Gregory , Ashton, Stuart, Aston, Pia , Astone, Florian , Aubin, Peter , Aufmuth, Kellie , Aultoneal, Corey , Austin, Valerie , Avendano, Stanislav , Babak, Philippe , Bacon, Francesca , Badaracco, Maria, Bader, Sangwook , Bae, Anne, Baer, Jonathon , Baird, Baldaccini, Giulio , Ballardin, Stefan, Ballmer, Anna-marie , Bals, Alexander , Balsamo, Baltus, Sharan , Banagiri, Deepak , Bankar, Rameshwar, Bankar, Juan, Barayoga, Claudio , Barbieri, Barry, Barish, David , Barker, Kevin , Barkett, Pablo , Barneo, Fabrizio , Barone, Bryan , Barr, Lisa , Barsotti, Matteo , Barsuglia, Daniel , Barta, Jeffrey , Bartlett, Imre , Bartos, Riccardo , Bassiri, Andrea , Basti, Mateusz , Bawaj, Joseph, Bayley, Marco , Bazzan, Bence , Bécsy, Michal , Bejger, Imene , Belahcene, Angus, Bell, Deeksha , Beniwal, Michael, Benjamin, Joe, Bentley, Fabio , Bergamin, Beverly, Berger, Gerald , Bergmann, Sebastiano , Bernuzzi, Christopher, Berry, Diego , Bersanetti, Alessandro , Bertolini, Joseph , Betzwieser, Rohan , Bhandare, Ankit, Bhandari, Bidler, Edward , Biggs, Igor, Bilenko, Garilynn , Billingsley, Ross , Birney, Ofek , Birnholtz, Sebastien , Biscans, Bischi, Sylvia , Biscoveanu, Aparna , Bisht, Guldauren , Bissenbayeva, Massimiliano , Bitossi, Marieanne, Bizouard, Kent, Blackburn, Jonathan , Blackman, Carl, Blair, David, Blair, Ryan, Blair, Bobba, Nina , Bode, Michel , Boer, Yannick , 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Dennis , Ugolini, Unnikrishnan, Cs, Alexander, Urban, Samantha, Usman, Andrei, Utina, Henning , Vahlbruch, Vajente, Guillermo , Valdes, Valentini, Vallisneri, Niels , van , Bakel, Martin , Beuzekom, den , Brand, Chris , Van , Den , Broeck, Daniel, Vander-Hyde, der , Schaaf, Joris, Van , Heijningen, Marielle, van , Veggel, Marco , Vardaro, Vijay , Varma, Steve , Vass, Matyas , Vasúth, Alberto , Vecchio, Gabriele , Vedovato, John , Veitch, Peter, Veitch, Krishna , Venkateswara, Gautam , Venugopalan, Didier , Verkindt, Doga , Veske, Vetrano, Viceré, Aaron, Viets, Serena , Vinciguerra, David, Vine, Jeanyves , Vinet, Salvatore , Vitale, Francisco , Hernandez , Vivanco, Thomas , Helios , Vocca, Cheryl , Vorvick, Sergey, Vyatchanin, Andrew, Wade, Leslie, Wade, Wade, Rob , Walet, Marissa , Walker, Gavin, Wallace, Larry , Wallace, Sinead , Walsh, Jonathan, Wang, Sibo , Wang, Wenhui, Wang, Yifan, Wang, Robert, Ward, Zane, Warden, Jim , Warner, Was, Jennifer , Watchi, Betsy , Weaver, Li-wei , Wei, Weinert, Alan, Weinstein, Rainer , Weiss, Felix , Wellmann, Linqing , Wen, Weßels, Jonathan, Westhouse, Wette, John, Whelan, Bernard, Whiting, Whittle, Dennis, Wilken, Williams, Roy, Williams, Andrew, Williamson, Joshua, Willis, Benno , Willke, Winkler, Christopher, Wipf, Holger , Wittel, Graham , Woan, Janis , Woehler, Jared, Wofford, Chun-fung , Wong, Jennifer, Wright, David, Wu, Daniel, Wysocki, Liting , Xiao, Hiro , Yamamoto, Le , Yang, Yang , Ziyan , Min-jet, Yap, Maher , Yazback, David, Yeeles, Hang , Haocun , Shingheirobin , Yuen, Adam, Zadrożny, Zadrożny, Zanolin, Tatiana , Zelenova, Jean-pierre , Zendri, Zevin, Jue , Zhang, Liyuan , Teng , Chunnong , Zhao, Guoying , Minchuan , Zhou, Zifan , Xingjiang, Zhu, Aaron, Zimmerman, Michael, Zucker, John , Zweizig, Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), 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Commission, Grav. waves and fundamental physics, RS: FSE Grav. waves and fundamental physics, RS: FSE MSP, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aich, A., Aiello, L., Ain, A., Ajith, P., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., Aultoneal, K., Austin, C., Avendano, V., Babak, S., Bacon, P., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Baird, J., Baldaccini, F., Ballardin, G., Ballmer, S. W., Bals, A., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barkett, K., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Bécsy, B., Bejger, M., Belahcene, I., Bell, A. S., Beniwal, D., Benjamin, M. G., Bentley, J. D., Bergamin, F., Berger, B. K., Bergmann, G., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bidler, J., Biggs, E., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bissenbayeva, G., Bitossi, M., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossilkov, V., Bosveld, J., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brighenti, F., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannon, K. C., Cao, H., Cao, J., Carapella, G., Carbognani, F., Caride, S., Carney, M. F., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castañeda, J., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, O., Chakravarti, K., Chan, C., Chan, M., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chaturvedi, M., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Cheong, C. K., Chia, H. Y., Chiadini, F., Chierici, R., Chincarini, A., Chiummo, A., Cho, G., Cho, H. S., Cho, M., Christensen, N., Chu, Q., Chua, S., Chung, K. W., Chung, S., Ciani, G., Ciecielag, P., Cieślar, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, J. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D., Colleoni, M., Collette, C. G., Collins, C., Colpi, M., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Couvares, P., Covas, P. B., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Cripe, J., Croquette, M., Crowder, S. G., Cudell, J. -R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curylo, M., Canton, T. Dal, Dálya, G., Dana, A., Daneshgaran-Bajastani, L. M., D’Angelo, B., Danilishin, S. L., D’Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Debra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Delfavero, M., De Lillo, N., Del Pozzo, W., Demarchi, L. M., D’Emilio, V., Demos, N., Dent, T., De Pietri, R., De Rosa, R., De Rossi, C., Desalvo, R., de Varona, O., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz, M., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Downes, T. P., Drago, M., Driggers, J. C., Du, Z., Ducoin, J. -G., Dupej, P., Durante, O., D’Urso, D., Dwyer, S. E., Easter, P. J., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Ehrens, P., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Errico, L., Essick, R. C., Estelles, H., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fairhurst, S., Fan, X., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, E. C., Ferreira, T. A., Fidecaro, F., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fitz-Axen, M., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Forsyth, P. W. F., Fournier, J. -D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fritschel, P., Frolov, V. V., Fronzè, G., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Galaudage, S., Ganapathy, D., Gaonkar, S. G., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Gemme, G., Genin, E., Gennai, A., George, D., George, J., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giacomazzo, B., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Gill, K., Glanzer, J., Gniesmer, J., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gossan, S. E., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, E. M., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, Y., Gupta, A., Gupta, Anchal, Gupta, P., Gustafson, E. K., Gustafson, R., Haegel, L., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hasskew, R. K., Haster, C. -J., Haughian, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heitmann, H., Hellman, F., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Heurs, M., Hild, S., Hinderer, T., Hoback, S. Y., Hochheim, S., Hofgard, E., Hofman, D., Holgado, A. M., Holland, N. A., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Howell, E. J., Hoy, C. G., Huang, Y., Hübner, M. T., Huerta, E. A., Huet, D., Hughey, B., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Idzkowski, B., Iess, A., Inchauspe, H., Ingram, C., Intini, G., Isac, J. - M., Isi, M., Iyer, B. R., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jani, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jiang, J., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaufer, S., Kawabe, K., Kéfélian, F., Keitel, D., Keivani, A., Kennedy, R., Key, J. S., Khadka, S., Khalili, F. Y., Khan, I., Khan, S., Khan, Z. A., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, Chunglee, Kim, G. J., Kim, J. C., Kim, K., Kim, W., Kim, W. S., Kim, Y. -M., Kimball, C., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kleybolte, L., Klimenko, S., Knowles, T. D., Koch, P., Koehlenbeck, S. M., Koekoek, G., Koley, S., Kondrashov, V., Kontos, A., Koper, N., Korobko, M., Korth, W. Z., Kovalam, M., Kozak, D. B., Kringel, V., Krishnendu, N. V., Królak, A., Krupinski, N., Kuehn, G., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kumar, S., Kuo, L., Kutynia, A., Lackey, B. D., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., Lanza, R. K., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, C. H., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lehmann, J., Leroy, N., Letendre, N., Levin, Y., Li, A. K. Y., Li, J., Li, K., Li, T. G. F., Li, X., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, J., Liu, X., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., London, L. T., Longo, A., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lumaca, D., Lundgren, A. P., Ma, Y., Macas, R., Macfoy, S., Macinnis, M., Macleod, D. M., Macmillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magaña-Sandoval, F., Magee, R. M., Majorana, E., Maksimovic, I., Malik, A., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, V., Martynov, D. V., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Matichard, F., Mavalvala, N., Maynard, E., Mccann, J. J., Mccarthy, R., Mcclelland, D. E., Mccormick, S., Mcculler, L., Mcguire, S. C., Mcisaac, C., Mciver, J., Mcmanus, D. J., Mcrae, T., Mcwilliams, S. T., Meacher, D., Meadors, G. D., Mehmet, M., Mehta, A. K., Villa, E. Mejuto, Melatos, A., Mendell, G., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Middleton, H., Milano, L., Miller, A. L., Millhouse, M., Mills, J. C., Milotti, E., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Mishkin, A., Mishra, C., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Mo, G., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., Moreno, G., Morisaki, S., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukherjee, Subroto, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Nagar, A., Nardecchia, I., Naticchioni, L., Nayak, R. K., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Ng, K. Y., Ng, S., Nguyen, C., Nguyen, P., Nichols, D., Nichols, S. A., Nissanke, S., Nocera, F., Noh, M., North, C., Nothard, D., Nuttall, L. K., Oberling, J., O’Brien, B. D., Oganesyan, G., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Ohta, H., Okada, M. A., Oliver, M., Olivetto, C., Oppermann, P., Oram, Richard J., O’Reilly, B., Ormiston, R. G., Ortega, L. F., O’Shaughnessy, R., Ossokine, S., Osthelder, C., Ottaway, D. J., Overmier, H., Owen, B. J., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Panda, P. K., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Parida, A., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Payne, E., Pearlstone, B. L., Pechsiri, T. C., Pedersen, A. J., Pedraza, M., Pele, A., Penn, S., Perego, A., Perez, C. J., Périgois, C., Perreca, A., Perriès, S., Petermann, J., Pfeiffer, H. P., Phelps, M., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Piotrzkowski, K., Pirello, M., Pitkin, M., Plastino, W., Poggiani, R., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Powell, J., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Prestegard, T., Principe, M., Prodi, G. A., Prokhorov, L., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quinonez, P. J., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rafferty, H., Raja, S., Rajan, C., Rajbhandari, B., Rakhmanov, M., Ramirez, K. E., Ramos-Buades, A., Rana, Javed, Rao, K., Rapagnani, P., Raymond, V., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Rettegno, P., Ricci, F., Richardson, C. J., Richardson, J. W., Ricker, P. M., Riemenschneider, G., Riles, K., Rizzo, M., Robertson, N. A., Robinet, F., Rocchi, A., Rodriguez-Soto, R. D., Rolland, L., Rollins, J. G., Roma, V. J., Romanelli, M., Romano, R., Romel, C. L., Romero-Shaw, I. M., Romie, J. H., Rose, C. A., Rose, D., Rose, K., Rosińska, D., Rosofsky, S. G., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, P. K., Roy, Santosh, Roy, Soumen, Ruggi, P., Rutins, G., Ryan, K., Sachdev, S., Sadecki, T., Sakellariadou, M., Salafia, O. S., Salconi, L., Saleem, M., Samajdar, A., Sanchez, E. J., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Santiago, K. A., Santos, E., Sarin, N., Sassolas, B., Sathyaprakash, B. S., Sauter, O., Savage, R. L., Savant, V., Sawant, D., Sayah, S., Schaetzl, D., Schale, P., Scheel, M., Scheuer, J., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schulte, B. W., Schutz, B. F., Schwarm, O., Schwartz, E., Scott, J., Scott, S. M., Seidel, E., Sellers, D., Sengupta, A. S., Sennett, N., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D. A., Shaffer, T., Shahriar, M. S., Sharma, A., Sharma, P., Shawhan, P., Shen, H., Shikauchi, M., Shink, R., Shoemaker, D. H., Shoemaker, D. M., Shukla, K., Shyamsundar, S., Siellez, K., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Singhal, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Somala, S., Son, E. J., Soni, S., Sorazu, B., Sordini, V., Sorrentino, F., Souradeep, T., Sowell, E., Spencer, A. P., Spera, M., Srivastava, A. K., Srivastava, V., Staats, K., Stachie, C., Standke, M., Steer, D. A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stocks, D., Stops, D. J., Stover, M., Strain, K. A., Stratta, G., Strunk, A., Sturani, R., Stuver, A. L., Sudhagar, S., Sudhir, V., Summerscales, T. Z., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Tait, S. C., Talbot, C., Tanasijczuk, A. J., Tanner, D. B., Tao, D., Tápai, M., Tapia, A., Martin, E. N. Tapia San, Tasson, J. D., Taylor, R., Tenorio, R., Terkowski, L., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tinsman, C. L., Saravanan, T. R., Tiwari, Shubhanshu, Tiwari, S., Tiwari, V., Toland, K., Tonelli, M., Tornasi, Z., Torres-Forné, A., Torrie, C. I., Tosta e Melo, I., Töyrä, D., Trail, E. A., Travasso, F., Traylor, G., Tringali, M. C., Tripathee, A., Trovato, A., Trudeau, R. J., Tsang, K. W., Tse, M., Tso, R., Tsukada, L., Tsuna, D., Tsutsui, T., Turconi, M., Ubhi, A. S., Ueno, K., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Utina, A. C., Vahlbruch, H., Vajente, G., Valdes, G., Valentini, M., Vallisneri, M., van Bakel, N., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., Vander-Hyde, D. C., van der Schaaf, L., Van Heijningen, J. V., van Veggel, A. A., Vardaro, M., Varma, V., Vass, S., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venugopalan, G., Verkindt, D., Veske, D., Vetrano, F., Viceré, A., Viets, A. D., Vinciguerra, S., Vine, D. J., Vinet, J. -Y., Vitale, S., Vivanco, Francisco Hernandez, Vo, T., Vocca, H., Vorvick, C., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walet, R., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J. Z., Wang, S., Wang, W. H., Wang, Y. F., Ward, R. L., Warden, Z. A., Warner, J., Was, M., Watchi, J., Weaver, B., Wei, L. -W., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Weßels, P., Westhouse, J. W., Wette, K., Whelan, J. T., Whiting, B. F., Whittle, C., Wilken, D. M., Williams, D., Williams, R. D., Williamson, A. R., Willis, J. L., Willke, B., Winkler, W., Wipf, C. C., Wittel, H., Woan, G., Woehler, J., Wofford, J. K., Wong, C., Wright, J. L., Wu, D. S., Wysocki, D. M., Xiao, L., Yamamoto, H., Yang, L., Yang, Y., Yang, Z., Yap, M. J., Yazback, M., Yeeles, D. W., Yu, Hang, Yu, Haocun, Yuen, S. H. R., Zadrożny, A. K., Zadrożny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, T., Zhao, C., Zhao, G., Zhou, M., Zhou, Z., Zhu, X. J., Zimmerman, A. B., Zucker, M. E., Zweizig, J., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Nice Sophia Antipolis (... - 2019) (UNS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Abbott, R, Abbott, T, Abraham, S, Acernese, F, Ackley, K, Adams, C, Adhikari, R, Adya, V, Affeldt, C, Agathos, M, Agatsuma, K, Aggarwal, N, Aguiar, O, Aich, A, Aiello, L, Ain, A, Ajith, P, Allen, G, Allocca, A, Altin, P, Amato, A, Anand, S, Ananyeva, A, Anderson, S, Anderson, W, Angelova, S, Ansoldi, S, Antier, S, Appert, S, Arai, K, Araya, M, Areeda, J, Arene, M, Arnaud, N, Aronson, S, Arun, K, Ascenzi, S, Ashton, G, Aston, S, Astone, P, Aubin, F, Aufmuth, P, Aultoneal, K, Austin, C, Avendano, V, Babak, S, Bacon, P, Badaracco, F, Bader, M, Bae, S, Baer, A, Baird, J, Baldaccini, F, Ballardin, G, Ballmer, S, Bals, A, Balsamo, A, Baltus, G, Banagiri, S, Bankar, D, Bankar, R, Barayoga, J, Barbieri, C, Barish, B, Barker, D, Barkett, K, Barneo, P, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Bartos, I, Bassiri, R, Basti, A, Bawaj, M, Bayley, J, Bazzan, M, Becsy, B, Bejger, M, Belahcene, I, Bell, A, Beniwal, D, Benjamin, M, Bentley, J, Bergamin, F, Berger, B, Bergmann, G, Bernuzzi, S, Berry, C, Bersanetti, D, Bertolini, A, Betzwieser, J, Bhandare, R, Bhandari, A, Bidler, J, Biggs, E, Bilenko, I, Billingsley, G, Birney, R, Birnholtz, O, Biscans, S, Bischi, M, Biscoveanu, S, Bisht, A, Bissenbayeva, G, Bitossi, M, Bizouard, M, Blackburn, J, Blackman, J, Blair, C, Blair, D, Blair, R, Bobba, F, Bode, N, Boer, M, Boetzel, Y, Bogaert, G, Bondu, F, Bonilla, E, Bonnand, R, Booker, P, Boom, B, Bork, R, Boschi, V, Bose, S, Bossilkov, V, Bosveld, J, Bouffanais, Y, Bozzi, A, Bradaschia, C, Brady, P, Bramley, A, Branchesi, M, Brau, J, Breschi, M, Briant, T, Briggs, J, Brighenti, F, Brillet, A, Brinkmann, M, Brockill, P, Brooks, A, Brooks, J, Brown, D, Brunett, S, Bruno, G, Bruntz, R, Buikema, A, Bulik, T, Bulten, H, Buonanno, A, Buskulic, D, Byer, R, Cabero, M, Cadonati, L, Cagnoli, G, Cahillane, C, Bustillo, J, Callaghan, J, Callister, T, Calloni, E, Camp, J, Canepa, M, Cannon, K, Cao, H, Cao, J, Carapella, G, Carbognani, F, Caride, S, Carney, M, Carullo, G, Diaz, J, Casentini, C, Castaneda, J, Caudill, S, Cavaglia, M, Cavalier, F, Cavalieri, R, Cella, G, Cerda-Duran, P, Cesarini, E, Chaibi, O, Chakravarti, K, Chan, C, Chan, M, Chao, S, Charlton, P, Chase, E, Chassande-Mottin, E, Chatterjee, D, Chaturvedi, M, Chen, H, Chen, X, Chen, Y, Cheng, H, Cheong, C, Chia, H, Chiadini, F, Chierici, R, Chincarini, A, Chiummo, A, Cho, G, Cho, H, Cho, M, Christensen, N, Chu, Q, Chua, S, Chung, K, Chung, S, Ciani, G, Ciecielag, P, Cieslar, M, Ciobanu, A, Ciolfi, R, Cipriano, F, Cirone, A, Clara, F, Clark, J, Clearwater, P, Clesse, S, Cleva, F, Coccia, E, Cohadon, P, Cohen, D, Colleoni, M, Collette, C, Collins, C, Colpi, M, Constancio, M, Conti, L, Cooper, S, Corban, P, Corbitt, T, Cordero-Carrion, I, Corezzi, S, Corley, K, Cornish, N, Corre, D, Corsi, A, Cortese, S, Costa, C, Cotesta, R, Coughlin, M, Coughlin, S, Coulon, J, Countryman, S, Couvares, P, Covas, P, Coward, D, Cowart, M, Coyne, D, Coyne, R, Creighton, J, Creighton, T, Cripe, J, Croquette, M, Crowder, S, Cudell, J, Cullen, T, Cumming, A, Cummings, R, Cunningham, L, Cuoco, E, Curylo, M, Canton, T, Dalya, G, Dana, A, Daneshgaran-Bajastani, L, D'Angelo, B, Danilishin, S, D'Antonio, S, Danzmann, K, Darsow-Fromm, C, Dasgupta, A, Datrier, L, Dattilo, V, Dave, I, Davier, M, Davies, G, Davis, D, Daw, E, Debra, D, Deenadayalan, M, Degallaix, J, De Laurentis, M, Deleglise, S, Delfavero, M, De Lillo, N, Del Pozzo, W, Demarchi, L, D'Emilio, V, Demos, N, Dent, T, De Pietri, R, De Rosa, R, De Rossi, C, Desalvo, R, de Varona, O, Dhurandhar, S, Diaz, M, Diaz-Ortiz, M, Dietrich, T, Di Fiore, L, Di Fronzo, C, Di Giorgio, C, Di Giovanni, F, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Ding, B, Di Pace, S, Di Palma, I, Di Renzo, F, Divakarla, A, Dmitriev, A, Doctor, Z, Donovan, F, Dooley, K, Doravari, S, Dorrington, I, Downes, T, Drago, M, Driggers, J, Du, Z, Ducoin, J, Dupej, P, Durante, O, D'Urso, D, Dwyer, S, Easter, P, Eddolls, G, Edelman, B, Edo, T, Edy, O, Effler, A, Ehrens, P, Eichholz, J, Eikenberry, S, Eisenmann, M, Eisenstein, R, Ejlli, A, Errico, L, Essick, R, Estelles, H, Estevez, D, Etienne, Z, Etzel, T, Evans, M, Evans, T, Ewing, B, Fafone, V, Fairhurst, S, Fan, X, Farinon, S, Farr, B, Farr, W, Fauchon-Jones, E, Favata, M, Fays, M, Fazio, M, Feicht, J, Fejer, M, Feng, F, Fenyvesi, E, Ferguson, D, Fernandez-Galiana, A, Ferrante, I, Ferreira, E, Ferreira, T, Fidecaro, F, Fiori, I, Fiorucci, D, Fishbach, M, Fisher, R, Fittipaldi, R, Fitz-Axen, M, Fiumara, V, Flaminio, R, Floden, E, Flynn, E, Fong, H, Font, J, Forsyth, P, Fournier, J, Frasca, S, Frasconi, F, Frei, Z, Freise, A, Frey, R, Frey, V, Fritschel, P, Frolov, V, Fronze, G, Fulda, P, Fyffe, M, Gabbard, H, Gadre, B, Gaebel, S, Gair, J, Galaudage, S, Ganapathy, D, Gaonkar, S, Garcia-Quiros, C, Garufi, F, Gateley, B, Gaudio, S, Gayathri, V, Gemme, G, Genin, E, Gennai, A, George, D, George, J, Gergely, L, Ghonge, S, Ghosh, A, Ghosh, S, Giacomazzo, B, Giaime, J, Giardina, K, Gibson, D, Gier, C, Gill, K, Glanzer, J, Gniesmer, J, Godwin, P, Goetz, E, Goetz, R, Gohlke, N, Goncharov, B, Gonzalez, G, Gopakumar, A, Gossan, S, Gosselin, M, Gouaty, R, Grace, B, Grado, A, Granata, M, Grant, A, Gras, S, Grassia, P, Gray, C, Gray, R, Greco, G, Green, A, Green, R, Gretarsson, E, Griggs, H, Grignani, G, Grimaldi, A, Grimm, S, Grote, H, Grunewald, S, Gruning, P, Guidi, G, Guimaraes, A, Guixe, G, Gulati, H, Guo, Y, Gupta, A, Gupta, P, Gustafson, E, Gustafson, R, Haegel, L, Halim, O, Hall, E, Hamilton, E, Hammond, G, Haney, M, Hanke, M, Hanks, J, Hanna, C, Hannam, M, Hannuksela, O, Hansen, T, Hanson, J, Harder, T, Hardwick, T, Haris, K, Harms, J, Harry, G, Harry, I, Hasskew, R, Haster, C, Haughian, K, Hayes, F, Healy, J, Heidmann, A, Heintze, M, Heinze, J, Heitmann, H, Hellman, F, Hello, P, Hemming, G, Hendry, M, Heng, I, Hennes, E, Hennig, J, Heurs, M, Hild, S, Hinderer, T, Hoback, S, Hochheim, S, Hofgard, E, Hofman, D, Holgado, A, Holland, N, Holt, K, Holz, D, Hopkins, P, Horst, C, Hough, J, Howell, E, Hoy, C, Huang, Y, Hubner, M, Huerta, E, Huet, D, Hughey, B, Hui, V, Husa, S, Huttner, S, Huxford, R, Huynh-Dinh, T, Idzkowski, B, Iess, A, Inchauspe, H, Ingram, C, Intini, G, Isac, J, Isi, M, Iyer, B, Jacqmin, T, Jadhav, S, James, A, Jani, K, Janthalur, N, Jaranowski, P, Jariwala, D, Jaume, R, Jenkins, A, Jiang, J, Johns, G, Jones, A, Jones, D, Jones, J, Jones, P, Jones, R, Jonker, R, Ju, L, Junker, J, Kalaghatgi, C, Kalogera, V, Kamai, B, Kandhasamy, S, Kang, G, Kanner, J, Kapadia, S, Karki, S, Kashyap, R, Kasprzack, M, Kastaun, W, Katsanevas, S, Katsavounidis, E, Katzman, W, Kaufer, S, Kawabe, K, Kefelian, F, Keitel, D, Keivani, A, Kennedy, R, Key, J, Khadka, S, Khalili, F, Khan, I, Khan, S, Khan, Z, Khazanov, E, Khetan, N, Khursheed, M, Kijbunchoo, N, Kim, C, Kim, G, Kim, J, Kim, K, Kim, W, Kim, Y, Kimball, C, King, P, Kinley-Hanlon, M, Kirchhoff, R, Kissel, J, Kleybolte, L, Klimenko, S, Knowles, T, Koch, P, Koehlenbeck, S, Koekoek, G, Koley, S, Kondrashov, V, Kontos, A, Koper, N, Korobko, M, Korth, W, Kovalam, M, Kozak, D, Kringel, V, Krishnendu, N, Krolak, A, Krupinski, N, Kuehn, G, Kumar, A, Kumar, P, Kumar, R, Kumar, S, Kuo, L, Kutynia, A, Lackey, B, Laghi, D, Lalande, E, Lam, T, Lamberts, A, Landry, M, Lane, B, Lang, R, Lange, J, Lantz, B, Lanza, R, La Rosa, I, Lartaux-Vollard, A, Lasky, P, Laxen, M, Lazzarini, A, Lazzaro, C, Leaci, P, Leavey, S, Lecoeuche, Y, Lee, C, Lee, H, Lee, J, Lee, K, Lehmann, J, Leroy, N, Letendre, N, Levin, Y, Li, A, Li, J, Li, K, Li, T, Li, X, Linde, F, Linker, S, Linley, J, Littenberg, T, Liu, J, Liu, X, Llorens-Monteagudo, M, Lo, R, Lockwood, A, London, L, Longo, A, Lorenzini, M, Loriette, V, Lormand, M, Losurdo, G, Lough, J, Lousto, C, Lovelace, G, Luck, H, Lumaca, D, Lundgren, A, Ma, Y, Macas, R, Macfoy, S, Macinnis, M, Macleod, D, Macmillan, I, Macquet, A, Hernandez, I, Magana-Sandoval, F, Magee, R, Majorana, E, Maksimovic, I, Malik, A, Man, N, Mandic, V, Mangano, V, Mansell, G, Manske, M, Mantovani, M, Mapelli, M, Marchesoni, F, Marion, F, Marka, S, Marka, Z, Markakis, C, Markosyan, A, Markowitz, A, Maros, E, Marquina, A, Marsat, S, Martelli, F, Martin, I, Martin, R, Martinez, V, Martynov, D, Masalehdan, H, Mason, K, Massera, E, Masserot, A, Massinger, T, Masso-Reid, M, Mastrogiovanni, S, Matas, A, Matichard, F, Mavalvala, N, Maynard, E, Mccann, J, Mccarthy, R, Mcclelland, D, Mccormick, S, Mcculler, L, Mcguire, S, Mcisaac, C, Mciver, J, Mcmanus, D, Mcrae, T, Mcwilliams, S, Meacher, D, Meadors, G, Mehmet, M, Mehta, A, Villa, E, Melatos, A, Mendell, G, Mercer, R, Mereni, L, Merfeld, K, Merilh, E, Merritt, J, Merzougui, M, Meshkov, S, Messenger, C, Messick, C, Metzdorff, R, Meyers, P, Meylahn, F, Mhaske, A, Miani, A, Miao, H, Michaloliakos, I, Michel, C, Middleton, H, Milano, L, Miller, A, Millhouse, M, Mills, J, Milotti, E, Milovich-Goff, M, Minazzoli, O, Minenkov, Y, Mishkin, A, Mishra, C, Mistry, T, Mitra, S, Mitrofanov, V, Mitselmakher, G, Mittleman, R, Mo, G, Mogushi, K, Mohapatra, S, Mohite, S, Molina-Ruiz, M, Mondin, M, Montani, M, Moore, C, Moraru, D, Morawski, F, Moreno, G, Morisaki, S, Mours, B, Mow-Lowry, C, Mozzon, S, Muciaccia, F, Mukherjee, A, Mukherjee, D, Mukherjee, S, Mukund, N, Mullavey, A, Munch, J, Muniz, E, Murray, P, Nagar, A, Nardecchia, I, Naticchioni, L, Nayak, R, Neil, B, Neilson, J, Nelemans, G, Nelson, T, Nery, M, Neunzert, A, Ng, K, Ng, S, Nguyen, C, Nguyen, P, Nichols, D, Nichols, S, Nissanke, S, Nocera, F, Noh, M, North, C, Nothard, D, Nuttall, L, Oberling, J, O'Brien, B, Oganesyan, G, Ogin, G, Oh, J, Oh, S, Ohme, F, Ohta, H, Okada, M, Oliver, M, Olivetto, C, Oppermann, P, Oram, R, O'Reilly, B, Ormiston, R, Ortega, L, O'Shaughnessy, R, Ossokine, S, Osthelder, C, Ottaway, D, Overmier, H, Owen, B, Pace, A, Pagano, G, Page, M, Pagliaroli, G, Pai, A, Pai, S, Palamos, J, Palashov, O, Palomba, C, Pan, H, Panda, P, Pang, P, Pankow, C, Pannarale, F, Pant, B, Paoletti, F, Paoli, A, Parida, A, Parker, W, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patricelli, B, Payne, E, Pearlstone, B, Pechsiri, T, Pedersen, A, Pedraza, M, Pele, A, Penn, S, Perego, A, Perez, C, Perigois, C, Perreca, A, Perries, S, Petermann, J, Pfeiffer, H, Phelps, M, Phukon, K, Piccinni, O, Pichot, M, Piendibene, M, Piergiovanni, F, Pierro, V, Pillant, G, Pinard, L, Pinto, I, Piotrzkowski, K, Pirello, M, Pitkin, M, Plastino, W, Poggiani, R, Pong, D, Ponrathnam, S, Popolizio, P, Porter, E, Powell, J, Prajapati, A, Prasai, K, Prasanna, R, Pratten, G, Prestegard, T, Principe, M, Prodi, G, Prokhorov, L, Punturo, M, Puppo, P, Purrer, M, Qi, H, Quetschke, V, Quinonez, P, Raab, F, Raaijmakers, G, Radkins, H, Radulesco, N, Raffai, P, Rafferty, H, Raja, S, Rajan, C, Rajbhandari, B, Rakhmanov, M, Ramirez, K, Ramos-Buades, A, Rana, J, Rao, K, Rapagnani, P, Raymond, V, Razzano, M, Read, J, Regimbau, T, Rei, L, Reid, S, Reitze, D, Rettegno, P, Ricci, F, Richardson, C, Richardson, J, Ricker, P, Riemenschneider, G, Riles, K, Rizzo, M, Robertson, N, Robinet, F, Rocchi, A, Rodriguez-Soto, R, Rolland, L, Rollins, J, Roma, V, Romanelli, M, Romano, R, Romel, C, Romero-Shaw, I, Romie, J, Rose, C, Rose, D, Rose, K, Rosinska, D, Rosofsky, S, Ross, M, Rowan, S, Rowlinson, S, Roy, P, Roy, S, Ruggi, P, Rutins, G, Ryan, K, Sachdev, S, Sadecki, T, Sakellariadou, M, Salafia, O, Salconi, L, Saleem, M, Samajdar, A, Sanchez, E, Sanchez, L, Sanchis-Gual, N, Sanders, J, Santiago, K, Santos, E, Sarin, N, Sassolas, B, Sathyaprakash, B, Sauter, O, Savage, R, Savant, V, Sawant, D, Sayah, S, Schaetzl, D, Schale, P, Scheel, M, Scheuer, J, Schmidt, P, Schnabel, R, Schofield, R, Schonbeck, A, Schreiber, E, Schulte, B, Schutz, B, Schwarm, O, Schwartz, E, Scott, J, Scott, S, Seidel, E, Sellers, D, Sengupta, A, Sennett, N, Sentenac, D, Sequino, V, Sergeev, A, Setyawati, Y, Shaddock, D, Shaffer, T, Shahriar, M, Sharma, A, Sharma, P, Shawhan, P, Shen, H, Shikauchi, M, Shink, R, Shoemaker, D, Shukla, K, Shyamsundar, S, Siellez, K, Sieniawska, M, Sigg, D, Singer, L, Singh, D, Singh, N, Singha, A, Singhal, A, Sintes, A, Sipala, V, Skliris, V, Slagmolen, B, Slaven-Blair, T, Smetana, J, Smith, J, Smith, R, Somala, S, Son, E, Soni, S, Sorazu, B, Sordini, V, Sorrentino, F, Souradeep, T, Sowell, E, Spencer, A, Spera, M, Srivastava, A, Srivastava, V, Staats, K, Stachie, C, Standke, M, Steer, D, Steinke, M, Steinlechner, J, Steinlechner, S, Steinmeyer, D, Stocks, D, Stops, D, Stover, M, Strain, K, Stratta, G, Strunk, A, Sturani, R, Stuver, A, Sudhagar, S, Sudhir, V, Summerscales, T, Sun, L, Sunil, S, Sur, A, Suresh, J, Sutton, P, Swinkels, B, Szczepanczyk, M, Tacca, M, Tait, S, Talbot, C, Tanasijczuk, A, Tanner, D, Tao, D, Tapai, M, Tapia, A, Martin, E, Tasson, J, Taylor, R, Tenorio, R, Terkowski, L, Thirugnanasambandam, M, Thomas, M, Thomas, P, Thompson, J, Thondapu, S, Thorne, K, Thrane, E, Tinsman, C, Saravanan, T, Tiwari, S, Tiwari, V, Toland, K, Tonelli, M, Tornasi, Z, Torres-Forne, A, Torrie, C, Tosta e Melo, I, Toyra, D, Trail, E, Travasso, F, Traylor, G, Tringali, M, Tripathee, A, Trovato, A, Trudeau, R, Tsang, K, Tse, M, Tso, R, Tsukada, L, Tsuna, D, Tsutsui, T, Turconi, M, Ubhi, A, Ueno, K, Ugolini, D, Unnikrishnan, C, Urban, A, Usman, S, Utina, A, Vahlbruch, H, Vajente, G, Valdes, G, Valentini, M, Vallisneri, M, van Bakel, N, van Beuzekom, M, van den Brand, J, Van Den Broeck, C, Vander-Hyde, D, van der Schaaf, L, Van Heijningen, J, van Veggel, A, Vardaro, M, Varma, V, Vass, S, Vasuth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P, Venkateswara, K, Venugopalan, G, Verkindt, D, Veske, D, Vetrano, F, Vicere, A, Viets, A, Vinciguerra, S, Vine, D, Vinet, J, Vitale, S, Vivanco, F, Vo, T, Vocca, H, Vorvick, C, Vyatchanin, S, Wade, A, Wade, L, Wade, M, Walet, R, Walker, M, Wallace, G, Wallace, L, Walsh, S, Wang, J, Wang, S, Wang, W, Wang, Y, Ward, R, Warden, Z, Warner, J, Was, M, Watchi, J, Weaver, B, Wei, L, Weinert, M, Weinstein, A, Weiss, R, Wellmann, F, Wen, L, Wessels, P, Westhouse, J, Wette, K, Whelan, J, Whiting, B, Whittle, C, Wilken, D, Williams, D, Williams, R, Williamson, A, Willis, J, Willke, B, Winkler, W, Wipf, C, Wittel, H, Woan, G, Woehler, J, Wofford, J, Wong, C, Wright, J, Wu, D, Wysocki, D, Xiao, L, Yamamoto, H, Yang, L, Yang, Y, Yang, Z, Yap, M, Yazback, M, Yeeles, D, Yu, H, Yuen, S, Zadrozny, A, Zanolin, M, Zelenova, T, Zendri, J, Zevin, M, Zhang, J, Zhang, L, Zhang, T, Zhao, C, Zhao, G, Zhou, M, Zhou, Z, Zhu, X, Zimmerman, A, Zucker, M, Zweizig, J, IoP (FNWI), Faculty of Science, Gravitation and Astroparticle Physics Amsterdam, Other Research IHEF (IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The LIGO Scientific Collaboration, The Virgo Collaboration, Arene, M., Becsy, B., Bustillo, J. C., Diaz, J. C., Castaneda, J., Cavaglia, M., Cerda-Duran, P., Cieslar, M., Cordero-Carrion, I., Canton, T. D., Dalya, G., D'Angelo, B., D'Antonio, S., Deleglise, S., D'Emilio, V., Diaz, M. C., D'Urso, D., Fronze, G., Garcia-Quiros, C., Ghosh, A., Gonzalez, G., Guixe, G., Hubner, M. T., Isac, J. -M., Kefelian, F., Kim, C., Krolak, A., Kumar, R., Luck, H., Hernandez, I. M., Magana-Sandoval, F., Marka, S., Marka, Z., Villa, E. M., Mukherjee, A., Muniz, E. A., O'Brien, B. D., Oram, R. J., O'Reilly, B., O'Shaughnessy, R., Perigois, C., Perries, S., Pinto, I., Purrer, M., Rana, J., Rosinska, D., Roy, S., Schonbeck, A., Szczepanczyk, M. J., Tapai, M., Martin, E. N. T. S., Torres-Forne, A., Toyra, D., Vasuth, M., Vicere, A., Vivanco, F. H., Wessels, P., Yu, H., Zadrozny, A. K., and Zadrozny, A.
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Technology ,Gravitational Waves, Open Data, O1, O2, LIGO, Virgo ,Astronomy ,Strain measurement ,Gravitational Wave ,open data ,Data representation and management ,Gravitational Waves ,GWOSC ,Scientific databases ,gravitational waves ,01 natural sciences ,General Relativity and Quantum Cosmology ,Software ,Documentation ,DESIGN ,Open Data ,Computer software ,Data products ,LIGO ,QC ,12-AXIS VIBRATION ISOLATION ,media_common ,Settore FIS/01 ,0303 health sciences ,Gravitational effects ,BINARY MERGERS ,Computer Science Applications ,Open data ,[PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc] ,Open science ,Astrophysics - Instrumentation and Methods for Astrophysics ,data analysis method ,gr-qc ,media_common.quotation_subject ,Real-time computing ,FOS: Physical sciences ,O2 ,PUBLIC ADVANCED LIGO ,General Relativity and Quantum Cosmology (gr-qc) ,Gravity waves ,programming ,O1 ,03 medical and health sciences ,QA76.75-76.765 ,Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik ,SDG 17 - Partnerships for the Goals ,GWOSC, Scientific databases, Data representation and management, Gravitational Waves ,0103 physical sciences ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,010306 general physics ,GRAVITATIONAL-WAVE CATALOG ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,STFC ,Astrophysique ,030304 developmental biology ,Science & Technology ,business.industry ,Gravitational wave ,Virgo ,gravitational radiation ,RCUK ,Strain data ,Data-quality information ,Computer Science, Software Engineering ,gravitational radiation detector ,detector: sensitivity ,Scientific database ,monitoring ,VIRGO ,Sky ,gravitational radiation: emission ,Computer Science ,ddc:004 ,business ,astro-ph.IM - Abstract
Abbot, Rich, et al. (Virgo and MAGIC Collaboration), Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software., The authors gratefully acknowledge the support of the United States National Science Foundation (NSF) for the construction and operation of the LIGO Laboratory and Advanced LIGO as well as the Science and Technology Facilities Council (STFC) of the United Kingdom, the Max-Planck-Society (MPS), and the State of Niedersachsen/Germany for support of the construction of Advanced LIGO and construction and operation of the GEO600 detector. Additional support for Advanced LIGO was provided by the Australian Research Council. The authors gratefully acknowledge the Italian Istituto Nazionale di Fisica Nucleare (INFN), the French Centre National de la Recherche Scientifique (CNRS) and the Foundation for Fundamental Research on Matter supported by the Netherlands Organisation for Scientific Research, for the construction and operation of the Virgo detector and the creation and support of the EGO consortium. The authors also gratefully acknowledge research support from these agencies as well as by the Council of Scientific and Industrial Research of India, the Department of Science and Technology, India, the Science & Engineering Research Board (SERB), India, the Ministry of Human Resource Development, India, the Spanish Agencia Estatal de Investigación, the Vicepresidència i Conselleria d’Innovació, Recerca i Turisme and the Conselleria d’Educació i Universitat del Govern de les Illes Balears, the Conselleria d’Educació, Investigació, Cultura i Esport de la Generalitat Valenciana, the National Science Centre of Poland, the Swiss National Science Foundation (SNSF), the Russian Foundation for Basic Research, the Russian Science Foundation, the European Commission, the European Regional Development Funds (ERDF), the Royal Society, the Scottish Funding Council, the Scottish Universities Physics Alliance, the Hungarian Scientific Research Fund (OTKA), the Lyon Institute of Origins (LIO), the Paris Île-de-France Region, the National Research, Development and Innovation Office Hungary (NKFIH), the National Research Foundation of Korea, Industry Canada and the Province of Ontario through the Ministry of Economic Development and Innovation, the Natural Science and Engineering Research Council Canada, the Canadian Institute for Advanced Research, the Brazilian Ministry of Science, Technology, Innovations, and Communications, the International Center for Theoretical Physics South American Institute for Fundamental Research (ICTP-SAIFR), the Research Grants Council of Hong Kong, the National Natural Science Foundation of China (NSFC), the Leverhulme Trust, the Research Corporation, the Ministry of Science and Technology (MOST), Taiwan and the Kavli Foundation. The authors gratefully acknowledge the support of the NSF, STFC, INFN and CNRS for provision of computational resources.
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- 2021
25. Treatment of infants with ureteropelvic junction obstruction: findings from the PURSUIT network
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Jordon C. King, Elizabeth Juarez-Colunga, Gemma Beltran, Nicolette K. Janzen, Parker Adams, George Chiang, Vijaya M. Vemulakonda, Carter Sevick, Emily Ewing, Allison Kempe, and Alison W. Saville
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Nephrology ,Pyeloplasty ,medicine.medical_specialty ,Pediatrics ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Ureteropelvic junction ,Hydronephrosis ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Initial visit ,Electronic health record ,Internal medicine ,medicine ,Humans ,Kidney Pelvis ,In patient ,business.industry ,Infant ,medicine.disease ,Prenatal Hydronephrosis ,Treatment Outcome ,medicine.anatomical_structure ,Urologic Surgical Procedures ,business ,Ureteral Obstruction - Abstract
PURPOSE: Studies based on administrative databases show that infant pyeloplasty is associated with minority race/ethnicity but lack clinical data that may influence treatment. Our objective was to identify clinical and demographic factors associated with pyeloplasty in infants from three large tertiary centers. METHODS: We reviewed infants with unilateral Society for Fetal Urology (SFU) grade 3-4 hydronephrosis seen at three tertiary centers from 2/1/2018-9/30/2019. Patients were excluded if > 6 months old or treated surgically prior to the initial visit. Outcomes were: pyeloplasty < age 1 year and SFU grade on most recent ultrasound (US) within the first year. Covariables included: age at the initial visit, race/ethnicity, treating site, insurance type, febrile UTI, and initial imaging findings. Univariable and multivariable analyses were performed using log-rank tests and Cox proportional hazards models, respectively. RESULTS: 197 patients met study criteria; 19.3% underwent pyeloplasty. Pyeloplasty was associated with: treating site (p=0.03), SFU 4 on initial US (p =0.001), MAG-3 (p 20 minutes (p < 0.001) in patients undergoing a MAG-3 (n=107). MAG-3 (p
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- 2021
26. Horizons and Group Motivational Enhancement Therapy: HIV Prevention for Alcohol-Using Young Black Women, a Randomized Experiment
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Jessica M. Sales, Ariadna Capasso, Ralph J. DiClemente, James W. Hardin, Gina M. Wingood, Sarah W. Feldstein Ewing, Erin L. P. Bradley, Stephen G. West, Tiffaney L. Renfro, Teaniese L. Davis, Jennifer L. Brown, Angela D. Bryan, Yu Liu, Janet E. Rosenbaum, and Eve Rose
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Georgia ,Epidemiology ,Sexual Behavior ,media_common.quotation_subject ,Gonorrhea ,Sexually Transmitted Diseases ,Psychological intervention ,HIV Infections ,law.invention ,Condoms ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Condom ,law ,030225 pediatrics ,medicine ,Humans ,030212 general & internal medicine ,Poisson regression ,media_common ,Chlamydia ,business.industry ,Random assignment ,Public Health, Environmental and Occupational Health ,Motivational enhancement therapy ,Abstinence ,medicine.disease ,Black or African American ,Alcoholism ,symbols ,Female ,business ,Demography - Abstract
Introduction Black women are at disproportionately greater risk for HIV and sexually transmitted infections than women of other ethnic/racial backgrounds. Alcohol use may further elevate the risk of HIV/sexually transmitted infection acquisition and transmission. Study Design A random-assignment parallel-group comparative treatment efficacy trial was conducted with random assignment to 1 of 3 conditions. Setting/participants The sample comprised 560 Black or African American women aged 18–24 years who reported recent unprotected vaginal or anal sex and recent alcohol use. Participants were recruited from community settings in Atlanta, Georgia, from January 2012 to February 2014. Intervention A Group Motivational Enhancement Therapy module was designed to complement a Centers for Disease Control and Prevention–designated evidence-based intervention (Horizons) to reduce sexual risk behaviors, alcohol use, and sexually transmitted infections, with 3 comparison groups: (1) Horizons + Group Motivational Enhancement Therapy intervention, (2) Horizons + General Health Promotion intervention, and (3) enhanced standard of care. Main outcome measures Outcome measures included safe sex (abstinence or 100% condom use); condom nonuse; proportion of condom use during sexual episodes; incident chlamydia, gonorrhea, and trichomonas infections; and problematic alcohol use measured by Alcohol Use Disorders Identification Test score. Treatment effects were estimated using an intention-to-treat protocol‒generalized estimating equations with logistic regression for binomial outcomes and Poisson regression for count outcomes. Analyses were conducted between October 2018 and October 2019. Results Participants assigned to Horizons + Group Motivational Enhancement Therapy had greater odds of safe sex (AOR=1.45, 95% CI=1.04, 2.02, p=0.03), greater proportion of condom use (AOR=1.68, 95% CI=1.18, 2.41, p=0.004), and lower odds of condom nonuse (AOR=0.57, 95% CI=0.38, 0.83, p=0.004). Both interventions had lower odds of problematic alcohol use (Horizons: AOR=0.57, 95% CI=0.39, 0.85, p=0.006; Horizons + Group Motivational Enhancement Therapy: AOR=0.61, 95% CI=0.41, 0.90, p=0.01). Conclusions Complementing an evidence-based HIV prevention intervention with Group Motivational Enhancement Therapy may increase safer sexual behaviors and concomitantly reduce alcohol use among young Black women who consume alcohol. Trial registration This study is registered at www.clinicaltrials.gov NCT01553682.
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- 2021
27. Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats
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Andreas W. Loepke, Samuel Y. Lee, Jeong-Rim Lee, Bingqing Zhang, Steve C. Danzer, Brian A. Upton, Rylon D. Hofacer, Bernadin Joseph, and Loren Ewing
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Apoptosis ,Hippocampal formation ,Neuroprotection ,Sevoflurane ,Heart rate ,Animals ,Hypnotics and Sedatives ,Medicine ,Rats, Wistar ,Dexmedetomidine ,General anaesthetic ,Oxygen saturation (medicine) ,Cell Death ,Dose-Response Relationship, Drug ,business.industry ,Neurotoxicity ,Brain ,medicine.disease ,Rats ,Neuroprotective Agents ,Anesthesiology and Pain Medicine ,Animals, Newborn ,Anesthesia ,Anesthetics, Inhalation ,Neurotoxicity Syndromes ,business ,medicine.drug - Abstract
Background Structural brain abnormalities in newborn animals after prolonged exposure to all routinely used general anaesthetics have raised substantial concerns for similar effects occurring in millions of children undergoing surgeries annually. Combining a general anaesthetic with non-injurious sedatives may provide a safer anaesthetic technique. We tested dexmedetomidine as a mitigating therapy in a sevoflurane dose-sparing approach. Methods Neonatal rats were randomised to 6 h of sevoflurane 2.5%, sevoflurane 1% with or without three injections of dexmedetomidine every 2 h (resulting in 2.5, 5, 10, 25, 37.5, or 50 μg kg−1 h−1), or fasting in room air. Heart rate, oxygen saturation, level of hypnosis, and response to pain were measured during exposure. Neuronal cell death was quantified histologically after exposure. Results Sevoflurane at 2.5% was more injurious than at 1% in the hippocampal cornu ammonis (CA)1 and CA2/3 subfields; ventral posterior and lateral dorsal thalamic nuclei; prefrontal, retrosplenial, and somatosensory cortices; and subiculum. Although sevoflurane 1% did not provide complete anaesthesia, supplementation with dexmedetomidine dose dependently increased depth of anaesthesia and diminished responses to pain. The combination of sevoflurane 1% and dexmedetomidine did not reliably reduce neuronal apoptosis relative to an equianaesthetic dose of sevoflurane 2.5%. Conclusions A sub-anaesthetic dose of sevoflurane combined with dexmedetomidine achieved a level of anaesthesia comparable with that of sevoflurane 2.5%. Similar levels of anaesthesia caused comparable programmed cell death in several developing brain regions. Depth of anaesthesia may be an important factor when comparing the neurotoxic effects of different anaesthetic regimens.
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- 2021
28. Orbital Volumetric Analysis in Patients With Unicoronal Craniosynostosis
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Brendan J. Cronin, Emily Ewing, George N. Kamel, Amanda A. Gosman, Ryan M McKee, Samuel Lance, Justin Ryan, M Kristine Carbullido, and Michelle V. Zaldana-Flynn
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genetic structures ,medicine.medical_treatment ,Unicoronal craniosynostosis ,Osteogenesis, Distraction ,030230 surgery ,Craniosynostoses ,03 medical and health sciences ,Quadrant (abdomen) ,0302 clinical medicine ,Cranial vault ,medicine ,Deformity ,Humans ,Retrospective Studies ,Fibrous joint ,Orthodontics ,business.industry ,Skull ,Infant ,eye diseases ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Distraction osteogenesis ,Surgery ,Zygomatic arch ,sense organs ,medicine.symptom ,business ,Orbit ,Orbit (anatomy) - Abstract
BACKGROUND Unicoronal craniosynostosis is associated with orbital restriction and asymmetry. Surgical treatment aims to both correct the aesthetic deformity and prevent the development of ocular dysfunction. We used orbital quadrant and hemispheric volumetric analysis to assess orbital restriction and compare the effectiveness of distraction osteogenesis with anterior rotational cranial flap (DO) and bilateral fronto-orbital advancement and cranial vault remodeling (FOAR) with respect to the correction of orbital restriction in patients with unicoronal craniosynostosis. METHODS A retrospective review of all patients with a diagnosis of unicoronal craniosynostosis and treated with either DO or FOAR from 2000 to 2019 was performed. Preoperative and postoperative total orbital volumes, as well as quadrant and hemispheric volume ratios, were calculated from 3-dimensional head computed tomography scans. Selected preoperative and postoperative orbital measurements, including the maxillary length of the orbit (MLO; zygomaticofrontal suture to the top of zygomatic arch) and the sphenoid length of the orbit (SLO; the top of sphenoid suture to the top of zygomatic arch), were also obtained. RESULTS Data were available for 28 patients with unicoronal craniosynostosis. Mean preoperative total orbital volume was significantly smaller on the synostotic side compared with the nonsynostotic side (10.94 vs 12.20 cm3, P = 0.04). Preoperative MLO and SLO were significantly longer on the synostotic side compared with the nonsynostotic side (MLO: 20.26 vs 17.75 mm, P < 0.001; SLO: 26.91 vs 24.93 mm, P = 0.01). Distraction osteogenesis and FOAR produced significantly different changes in orbital quadrant and/or hemispheric volume ratios on the nonsynostotic side but not on the synostotic side. CONCLUSIONS Before correction, patients with unicoronal craniosynostosis have significantly smaller total orbital volumes on the synostotic side compared with the nonsynostotic side and significantly greater MLO and SLO on the synostotic side compared with the nonsynostotic side. There is no significant difference between DO and FOAR with regard to correcting the observed orbital restriction in these patients.
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- 2021
29. Using AI predicted personality to enhance advertising effectiveness
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Holly Cooper, Michael Thomas Ewing, and Michael Shumanov
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Marketing ,Persuasion ,business.industry ,media_common.quotation_subject ,05 social sciences ,Advertising ,Purchasing ,Contextual design ,Personality type ,0502 economics and business ,Retail banking ,Personality ,050211 marketing ,Big Five personality traits ,business ,Psychology ,050203 business & management ,Consumer behaviour ,media_common - Abstract
PurposeThe purpose of this study is twofold: first to demonstrate the application of an algorithm using contextual data to ascertain consumer personality traits; and second to explore the factors impacting the relationship between personality traits and advertisement persuasiveness.Design/methodology/approachA mixed-method approach that comprises two distinct yet complementary studies. The first uses quantitative methods and is based on a sample of 35,264 retail banking customers. Study 2 explores the findings that emerge from Study 1 using qualitative methods.FindingsThis paper finds that matching consumer personality with congruent advertising messages can lead to more effective consumer persuasion for most personality types. For consumers who exhibit neurotic personality traits, ameliorating perceived risks during purchasing and providing cues for social acceptance and goal attainment are important factors for advertising effectiveness. These factors also had a positive impact on the purchasing behaviour of extroverted consumers.Research limitations/implicationsThis research focusses on understanding purchasing behaviour based on the most dominant personality trait. However, people are likely to exhibit a combination of most or even all of the Big Five personality traits.Practical implicationsBuilding on advances in natural language processing, enabling the identification of personality from language, this study demonstrates the possibility of influencing consumer behaviour by matching machine inferred personality to congruent persuasive advertising. It is one of the few studies to use contextual instead of social media data to capture individual personality. Such data serves to capture an authentic rather than contrived persona. Further, the study identifies the factors that may moderate this relationship and thereby provides an explanation of why some personality traits exhibit differences in purchasing behaviour from those that are anticipated by existing theory.Originality/valueAlthough the idea that people are more likely to be responsive to advertising messages that are congruent with their personality type has already been successfully applied by advertising practitioners and documented by advertising scholars, this study extends existing research by identifying the factors that may moderate this relationship and thereby provides an explanation why some personality traits may exhibit differences in purchasing behaviour from those that are anticipated by existing theory.
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- 2021
30. Package Design and Analysis for Vertical Gallium Nitride Field Effect Transistors
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John Harris, David Huitink, and Daniel J. Ewing
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chemistry.chemical_compound ,Materials science ,chemistry ,business.industry ,Package design ,Optoelectronics ,Pharmacology (medical) ,Gallium nitride ,Field-effect transistor ,business - Abstract
Gallium nitride (GaN) is a wide band gap semi-conductor with superior electron mobility to silicon carbide. These properties allow for the design of high temperature capable devices with excellent on resistance and breakdown voltage for their size. However, bulk GaN is difficult to fabricate and doping for field effect transistor (FET) control has been elusive, so vertical GaN devices are not commonplace. This paper measures the characteristics of vertical GaN FETs in the development stage and discusses packaging them for fabrication feedback and for future high temperature aplications.
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- 2021
31. Diminished muscle oxygen uptake and fatigue in spinal muscular atrophy
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Umrao R. Monani, Carol Ewing Garber, Ashley M. Goodwin, Margarethe Hauschildt, Julia Cocchi, Kayla Coutts, Michael P. McDermott, Jacqueline Montes, Darryl C. De Vivo, Feliz Marie Hernandez, David Uher, Kayla M.D. Cornett, and Ashwini Rao
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Muscular Atrophy, Spinal ,Young Adult ,03 medical and health sciences ,Absorptiometry, Photon ,Oxygen Consumption ,0302 clinical medicine ,Cardiopulmonary exercise test ,Internal medicine ,medicine ,Humans ,Deoxygenated Hemoglobin ,Increased fatigue ,RC346-429 ,Child ,Muscle, Skeletal ,Exercise ,Research Articles ,Fatigue ,Aerobic capacity ,Spectroscopy, Near-Infrared ,business.industry ,General Neuroscience ,Mitochondrial Myopathies ,Spinal muscular atrophy ,Middle Aged ,SMA ,medicine.disease ,Oxygen uptake ,030104 developmental biology ,Ambulatory ,Exercise Test ,Cardiology ,Female ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,business ,human activities ,030217 neurology & neurosurgery ,RC321-571 ,Research Article - Abstract
Objective To estimate muscle oxygen uptake and quantify fatigue during exercise in ambulatory individuals with spinal muscular atrophy (SMA) and healthy controls. Methods Peak aerobic capacity (VO2peak) and workload (Wpeak) were measured by cardiopulmonary exercise test (CPET) in 19 ambulatory SMA patients and 16 healthy controls. Submaximal exercise (SME) at 40% Wpeak was performed for 10 minutes. Change in vastus lateralis deoxygenated hemoglobin, measured by near‐infrared spectroscopy, determined muscle oxygen uptake (ΔHHb) at rest and during CPET and SME. Dual energy X‐ray absorptiometry assessed fat‐free mass (FFM%). Fatigue was determined by percent change in workload or distance in the first compared to the last minute of SME (FatigueSME) and six‐minute walk test (Fatigue6MWT), respectively. Results ΔHHb‐PEAK, ΔHHb‐SME, VO2peak, Wpeak, FFM%, and 6MWT distance were lower (P
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- 2021
32. Randomized Controlled Trial of an Alcohol-related Sexual Risk Reduction Intervention with Adolescents: The Role of Neurocognitive Activation During Risky Decision-Making
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Sarah J. Schmiege, Eric W Claus, Sarah W. Feldstein Ewing, Renee E. Magnan, Angela D. Bryan, and Kent E. Hutchison
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medicine.medical_specialty ,030505 public health ,Social Psychology ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Alcohol ,Sexual risk reduction ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,Health psychology ,0302 clinical medicine ,Infectious Diseases ,chemistry ,Randomized controlled trial ,law ,Intervention (counseling) ,Medicine ,030212 general & internal medicine ,Cluster randomised controlled trial ,0305 other medical science ,business ,Neurocognitive ,Clinical psychology - Abstract
Justice-involved youth are at a higher risk of negative outcomes from sexual activity and alcohol use relative to their non-justice involved peers. In the current study, we tested the extent to which variability in neurocognitive response (i.e., activation in the right superior parietal lobule; rSPL) during a risky decision-making task moderated the success of a sexual risk reduction intervention. In a cluster randomized trial blocked by gender, justice-involved adolescents (N = 269) first completed a risky decision-making task during a magnetic resonance imaging (MRI) session, then were assigned to an information-only control (GINFO) or sexual risk reduction intervention incorporating alcohol risk reduction content (GPI + GMET) and then re-contacted every three months for one year. Youth in the GPI + GMET intervention reported less sexual risk behavior 12 months after intervention than those in the control. Although neurocognitive activation was associated with sexual risk behavior, it did not moderate intervention outcomes. This risk-reduction intervention appears to work equally well across a range of neurocognitive responses.
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- 2021
33. Accuracy of breast MRI in evaluating nodal status after neoadjuvant therapy in invasive lobular carcinoma
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Rita A. Mukhtar, Judy C. Boughey, Michael Alvarado, Case Brabham, Mary Kathryn Abel, Nola M. Hylton, Heather I. Greenwood, Laura J. Esserman, Jasmine Wong, Cheryl Ewing, Ruby Guo, and Tatiana Kelil
- Subjects
medicine.medical_specialty ,Axillary lymph nodes ,medicine.medical_treatment ,Clinical Trials and Supportive Activities ,Article ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Clinical Research ,Biopsy ,Breast Cancer ,medicine ,Breast MRI ,Pharmacology (medical) ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Stage (cooking) ,Neoadjuvant therapy ,RC254-282 ,Cancer ,screening and diagnosis ,medicine.diagnostic_test ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Sentinel node ,medicine.disease ,Detection ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Invasive lobular carcinoma ,Biomedical Imaging ,Cancer imaging ,Radiology ,Patient Safety ,business ,4.2 Evaluation of markers and technologies - Abstract
Neoadjuvant therapy in breast cancer can downstage axillary lymph nodes and reduce extent of axillary surgery. As such, accurate determination of nodal status after neoadjuvant therapy and before surgery impacts surgical management. There are scarce data on the diagnostic accuracy of breast magnetic resonance imaging (MRI) for nodal evaluation after neoadjuvant therapy in patients with invasive lobular carcinoma (ILC), a diffusely growing tumor type. We retrospectively analyzed patients with stage 1–3 ILC who underwent pre-operative breast MRI after either neoadjuvant chemotherapy or endocrine therapy at our institution between 2006 and 2019. Two breast radiologists reviewed MRIs and evaluated axillary nodes for suspicious features. All patients underwent either sentinel node biopsy or axillary dissection. We evaluated sensitivity, specificity, negative and positive predictive values, and overall accuracy of the post-treatment breast MRI in predicting pathologic nodal status. Of 79 patients, 58.2% received neoadjuvant chemotherapy and 41.8% neoadjuvant endocrine therapy. The sensitivity and negative predictive value of MRI were significantly higher in the neoadjuvant endocrine therapy cohort than in the neoadjuvant chemotherapy cohort (66.7 vs. 37.9%, p = 0.012 and 70.6 vs. 40%, p = 0.007, respectively), while overall accuracy was similar. Upstaging from clinically node negative to pathologically node positive occurred in 28.0 and 41.7%, respectively. In clinically node positive patients, those with an abnormal post-treatment MRI had a significantly higher proportion of patients with ≥4 positive nodes on pathology compared to those with a normal MRI (61.1 versus 16.7%, p = 0.034). Overall, accuracy of breast MRI for predicting nodal status after neoadjuvant therapy in ILC was low in both chemotherapy and endocrine therapy cohorts. However, post-treatment breast MRI may help identify patients with a high burden of nodal disease (≥4 positive nodes), which could impact pre-operative systemic therapy decisions. Further studies are needed to assess other imaging modalities to evaluate for nodal disease following neoadjuvant therapy and to improve clinical staging in patients with ILC.
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- 2021
34. Evaluation of a nationwide Dutch guideline to detect Lynch syndrome in patients with endometrial cancer
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K. Schelfhout, H.P.M. Smedts, A.A.M. van der Wurff, Anja Wagner, R.A. Smit, W. Dinjens, L. Hofman, A.S. Tjalsma, M.E.R. de Groot, Luthy S.M. Alcala, A.C. van Hof, P.J. Timmers, Patricia C. Ewing-Graham, B.A.J.T. Visschers, W. Hofhuis, H. C. van Doorn, K.E. Hamoen, K.J. Hoogduin, A.C.F. Makkus, S.J.J. Mol, G.M. Plaisier, P.M.L.H. Vencken, J. Kaijser, Obstetrics & Gynecology, Clinical Genetics, and Pathology
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Concordance ,Genetic counseling ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Internal medicine ,PMS2 ,medicine ,Humans ,Genetic Predisposition to Disease ,Aged ,Netherlands ,business.industry ,Endometrial cancer ,Obstetrics and Gynecology ,Microsatellite instability ,Guideline ,Middle Aged ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Immunohistochemistry ,Lynch syndrome ,Endometrial Neoplasms ,MSH6 ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Objective: In the Netherlands a nationwide guideline was introduced in 2016, which recommended routine Lynch syndrome screening (LSS) for all women with endometrial cancer (EC)
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- 2021
35. Commercialization of bulk nanostructured metals and alloys
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Terry C. Lowe, Ruslan Z. Valiev, Xiaochun Li, and Benjamin R. Ewing
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business.industry ,Manufacturing process ,Nanostructured materials ,Nanotechnology ,02 engineering and technology ,Advanced materials ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Commercialization ,0104 chemical sciences ,Characterization (materials science) ,Metallic materials ,General Materials Science ,Electronics ,Physical and Theoretical Chemistry ,0210 nano-technology ,Aerospace ,business - Abstract
Almost 30 years of research elucidating the mechanisms and reproducibility of nanostructuring has enabled the progressive emergence of reliable methods to manufacture bulk nanostructured metallic materials with superior properties. This article reviews examples of the use of nanostructured metals in engineered products that are currently commercially available, or will soon become available for specific biomedical, aerospace, electronics, and energy industry applications. The examples illustrate how the making and marketing of nanostructured materials follow similar development stages as other new advanced materials, but with additional challenges at each stage. Challenges include the difficulties of scaleup, intricacies of nanoscale characterization, the lack of consensus standards for product quality, competition with long-established conventional materials, regulatory hurdles associated with nanoscale technology, and consumer/user education on the virtues and limitations of nanostructuring. Finally, we discuss how the experiences to date with nanostructuring by various methods have established precedents that can guide manufacturing process development for advanced nanostructured metal and alloy applications.
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- 2021
36. Diagnosis and Management of Articular Cartilage and Meniscus Pathology in the Posterior Cruciate Ligament-Injured Knee
- Author
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James P. Stannard, James L. Cook, and Michael A. Ewing
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Cartilage, Articular ,Pathology ,medicine.medical_specialty ,Knee Joint ,Articular cartilage ,Knee Injuries ,Osteoarthritis ,Meniscus (anatomy) ,Menisci, Tibial ,medicine ,Humans ,Orthopedics and Sports Medicine ,business.industry ,Cartilage ,Treatment options ,Direct trauma ,musculoskeletal system ,medicine.disease ,Tibial Meniscus Injuries ,Review article ,medicine.anatomical_structure ,Posterior cruciate ligament ,Posterior Cruciate Ligament ,Surgery ,business ,Cartilage Diseases ,Algorithms - Abstract
Posterior cruciate ligament (PCL) injuries commonly occur in association with participation in sporting or recreational activities or due to a direct trauma. Cartilage and meniscal lesions are prevalent in PCL-injured knees with increasing likelihood and severity based on extent and duration of trauma to the knee. As such, comprehensive diagnostics should be performed to ascertain all related pathology, and patients should be thoroughly educated regarding treatment options, likely sequelae including posttraumatic osteoarthritis, and associated outcomes. Treatments should address the joint as an organ, ensuring stability, alignment, and functional tissue restoration are optimized by the most efficient and effective means possible. Compliance with patient- and procedure-specific postoperative management protocols is critical for optimizing successful outcomes for these complex cases. The objectives of this review article are to highlight the likelihood and importance of osteochondral and meniscal pathology in the PCL-injured knee, and to provide the best current evidence regarding comprehensive evaluation and management for PCL-injured knees with cartilage and/or meniscal comorbidities.
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- 2021
37. Analysis of Actual Versus Predicated Intracranial Volume Changes for Distraction Osteogenesis Using Virtual Surgical Planning in Patients With Craniosynostosis
- Author
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George N. Kamel, Amanda A. Gosman, Ryan M McKee, Michael G. Brandel, Samuel Lance, Mary Kristine Carbulido, Rachel M Segal, and Emily Ewing
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Osteogenesis, Distraction ,030230 surgery ,Surgical planning ,Craniosynostosis ,Craniosynostoses ,03 medical and health sciences ,0302 clinical medicine ,Primary outcome ,Intracranial volume ,Cranial vault ,Humans ,Medicine ,In patient ,Single institution ,Child ,Retrospective Studies ,business.industry ,Skull ,Infant ,medicine.disease ,Surgery ,030220 oncology & carcinogenesis ,Distraction osteogenesis ,Tomography, X-Ray Computed ,business - Abstract
INTRODUCTION The primary outcome metric in patients with craniosynostosis are changes in intracranial volumes (ICVs). In patients who undergo distraction osteogenesis (DO) to treat craniosynostosis, changes are also dependent on the length of distraction. Virtual surgical planning (VSP) has been used to predict anticipated changes in ICV during cranial vault reconstruction. The purpose of this study is to analyze the actual versus predicted ICV changes using VSP in patients who undergo DO for craniosynostosis management. METHODS All patients with craniosynostosis treated with DO at a single institution, Rady Children's Hospital, between December 2013 and May 2019 were identified. Inclusion criteria are as follows: VSP planning with predicted postoperative ICV values and preoperative and postdistraction CT scans to quantify ICV. Postoperative ICV and VSP-estimated ICV were adjusted for age-related ICV growth. The primary outcome measure calculated was age-adjusted percent volume change per millimeter distraction (PVCPD), and results were analyzed using paired Wilcoxon signed rank tests. RESULTS Twenty-seven patients underwent DO for cranial vault remodeling. Nineteen patients were nonsyndromic, and 8 patients were syndromic. The median postoperative PVCPD was 0.30%/mm, and the median VSP-estimated PVCPD was 0.36% per millimeter (P < 0.001). A subanalysis of nonsyndromic patients showed a median postoperative PVCPD of 0.29%/mm in nonsyndromic patients that differed significantly from the VSP estimate of 0.34%/mm (P = 0.003). There was also a significant difference in syndromic patients' observed PVCPD of 0.41%/mm versus VSP estimate of 0.79%/mm (P = 0.012). CONCLUSIONS Virtual surgical planning overestimates the change in ICV attributable to DO in both syndromic and nonsyndromic patients.
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- 2021
38. Hysteresis Reduction in Tunneling Magnetoresistive Sensor With AC Modulation Magnetic Field
- Author
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Amy Wilson, Joshua Trujillo, Dan Ewing, Y. Liu, Shu Hsien Liao, Sy Hwang Liou, Han-Sheng Huang, Andrei Sokolov, Yi Yang, and Xiaolu Yin
- Subjects
010302 applied physics ,Materials science ,Magnetoresistance ,business.industry ,Dynamic range ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Magnetic hysteresis ,01 natural sciences ,Noise (electronics) ,Electronic, Optical and Magnetic Materials ,Magnetic field ,Computer Science::Hardware Architecture ,Condensed Matter::Materials Science ,Hysteresis ,Modulation ,0103 physical sciences ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Quantum tunnelling - Abstract
A simple and practical ac modulation method to reduce the hysteresis in tunneling magnetoresistive (TMR) sensor is demonstrated. It is shown that with a suitable ac modulation magnetic field that is applied along the sensing direction of the TMR sensor, the hysteresis in the sensor can be reduced to a negligible level. Also, depending on the amplitude of the modulation field, the sensitivity and the dynamic range of the TMR sensor can be tuned to meet practical requirements in specific applications. The influence of the modulation on the noise of TMR sensor is also studied.
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- 2021
39. Investigating Bias from Missing Data in an Electronic Health Records-Based Study of Weight Loss After Bariatric Surgery
- Author
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David Fisher, Brianna Taylor, David Arterburn, James Fraser, Lily Koffman, Alexander W. Levis, Sebastien Haneuse, Mary Kay Theis, Heidi Fischer, Liyan Liu, Laura B. Amsden, Lisa J. Herrinton, Anita P. Courcoulas, Robert A Li, John Ewing, Julie Cooper, Eric O. Johnson, and Karen J. Coleman
- Subjects
Selection bias ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Weight change ,030209 endocrinology & metabolism ,Health records ,Logistic regression ,Missing data ,medicine.disease ,Obesity ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Weight loss ,Hispanic ethnicity ,Medicine ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,media_common - Abstract
Missing data is common in electronic health records (EHR)-based obesity research. To avoid bias, it is critical to understand mechanisms that underpin missingness. We conducted a survey among bariatric surgery patients in three integrated health systems to (i) investigate predictors of disenrollment and (ii) examine differences in weight between disenrollees and enrollees at 5 years. We identified 2883 patients who had bariatric surgery between 11/2013 and 08/2014. Patients who disenrolled before their 5-year anniversary were invited to participate in a survey to ascertain reasons for disenrollment and current weight. Logistic regression was used to investigate predictors of disenrollment. Five-year percent weight change distributions were estimated using inverse-probability weighting to adjust for (un)availability of EHR weight data at 5 years among enrollees and survey (non-)response among disenrollees. Among 536 disenrolled patients, 104 (19%) completed the survey. Among 2347 patients who maintained enrollment, 384 (16%) had no weight measurement in the EHR near 5 years. Insurance, age, Hispanic ethnicity, and site predicted disenrollment. Disenrollees had slightly greater weight loss than enrollees. We found little evidence of weight loss differences by enrollment status. Collecting information through surveys can be an effective tool to investigate and adjust for missingness in EHR-based studies.
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- 2021
40. Effects of Weight Loss on Obstructive Sleep Apnea Severity. Ten-Year Results of the Sleep AHEAD Study
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Samuel T. Kuna, David M. Reboussin, Elsa S. Strotmeyer, Richard P. Millman, Gary Zammit, Michael P. Walkup, Thomas A. Wadden, Rena R. Wing, F. Xavier Pi-Sunyer, Adam P. Spira, Gary D. Foster, Jon Freeman, Jennifer Patricio, Andrea Sifferman, Brian McGuckin, Stephanie Krauthamer-Ewing, Mary Jones-Parker, Matthew Anastasi, Beth Staley, Liz Roben, Marie Kearns, Caitlin Egan, Alexis Wojtanowski, Nida Cassim, Valerie Darcey, Sakhena Hin, and Stephanie Vander Veur
- Subjects
Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,business.industry ,Polysomnogram ,Critical Care and Intensive Care Medicine ,medicine.disease ,Sleep in non-human animals ,nervous system diseases ,respiratory tract diseases ,Obstructive sleep apnea ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,030228 respiratory system ,Lifestyle modification ,Apnea–hypopnea index ,Weight loss ,Lifestyle intervention ,medicine ,030212 general & internal medicine ,medicine.symptom ,business - Abstract
Rationale: Weight loss is recommended to treat obstructive sleep apnea (OSA).Objectives: To determine whether the initial benefit of intensive lifestyle intervention (ILI) for weight loss on OSA se...
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- 2021
41. A Posterior Rotational Flap Technique Using Distraction Osteogenesis for Unilateral Lambdoid Craniosynostosis
- Author
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Rachel M Segal, George N. Kamel, Ryan M McKee, Justin Ryan, Parham Gholami, Kristine Carbulido, Emily Ewing, Caitlyn Belza, Rishi Modi, Amanda A. Gosman, Samuel Lance, and Alyson O'Connor
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,education ,Osteogenesis, Distraction ,Unilateral lambdoid craniosynostosis ,Osteotomy ,Surgical planning ,Surgical Flaps ,Craniosynostoses ,03 medical and health sciences ,0302 clinical medicine ,Distraction ,Cranial vault ,Deformity ,Humans ,Medicine ,030223 otorhinolaryngology ,business.industry ,Skull ,Infant ,030206 dentistry ,General Medicine ,Perioperative ,Surgery ,Otorhinolaryngology ,Distraction osteogenesis ,medicine.symptom ,business - Abstract
Introduction The craniofacial asymmetry seen in unilateral lambdoid craniosynostosis may not be effectively treated by posterior cranial vault remodeling, endoscopic suturectomy, and helmet therapy, or suturectomy and distraction osteogenesis alone due to limitations in soft-tissue envelope expansion and relapse of the deformity. The authors report a series of unilateral lambdoid craniosynostosis patients treated with a posterior rotational cranial-flap technique using internal distraction osteogenesis. Methods Posterior cranial vault reconstruction combined with internal distraction was used, aided by preoperative virtual surgical planning. An in situ posterior rotational flap osteotomy was utilized to maximize dural preservation. Primary outcome measures included age-adjusted volume change and age-adjusted percent volume change per mm distraction. Distraction characteristics and perioperative characteristics were also assessed. Results A total of 5 patients were identified. Mean predistraction intracranial volume was 1087.5 cc (SD = 202.3 cc) and mean postdistraction included intracranial volume was 1266.1cc (SD = 131.8cc). Mean age-adjusted percent included intracranial volume change was 14.1% (SD = 9.6%), and mean percent intracranial volume change per mm distraction was 0.43%/mm distraction (SD = 0.37%/mm distraction). One patient developed a distractor site infection postoperatively that was treated successfully with oral antibiotics. All patients had a Whitaker score of 1 at one year follow up. Conclusions Posterior cranial vault remodeling using osteogenesis and a rotational cranial flap technique with dural preservation can be effectively used to maximize bone flap viability and limit postoperative relapse in patients with unilateral lambdoid craniosynostosis. Long term analysis as well as comparison to open techniques will need to be interrogated.
- Published
- 2021
42. A non-healing wound in a dog treated with hyperbaric oxygen therapy
- Author
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Charli Dong and Trenton S. Ewing
- Subjects
Hyperbaric oxygen ,business.industry ,Anesthesia ,Medicine ,General Medicine ,business - Published
- 2021
43. Current Outcomes of Blunt Vertebral Artery Injuries
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Andrew Sticco, Christopher G. Carsten, Sagar S. Gandhi, Eugene M. Langan, Bryan Knoedler, Geoff Marston, and Alex Ewing
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Vertebral artery ,030204 cardiovascular system & hematology ,Wounds, Nonpenetrating ,Time-to-Treatment ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Injury Severity Score ,0302 clinical medicine ,Blunt ,Trauma Centers ,medicine.artery ,Humans ,Medicine ,Registries ,Stroke ,Vertebral Artery ,Aged ,Retrospective Studies ,Aspirin ,business.industry ,Incidence ,Trauma center ,Glasgow Coma Scale ,Anticoagulants ,Retrospective cohort study ,General Medicine ,Middle Aged ,Vascular System Injuries ,medicine.disease ,Embolization, Therapeutic ,Polytrauma ,Surgery ,Treatment Outcome ,Female ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors - Abstract
Background There is no consensus on the treatment of blunt vertebral artery injuries, and studies are limited to small case series. We assessed the natural history and current management of these injuries. Methods We performed a retrospective study of a prospectively collected registry at a level I trauma center over a 5-year period. Additional information was gathered from patient charts and imaging review from electronic medical records. We analyzed demographics, mechanism of injury, Glasgow Coma Score, mortality, length of stay, associated injuries, Denver grading scale, neurological findings, level and laterality of injury, delay in diagnosis, treatment, and follow-up imaging. Results There were 13,080 trauma admissions during this time period yielding 141 patients with blunt vertebral artery injuries from 2013 to 2018 (1.1% incidence). Mean injury severity score (ISS) was 22 with a 30-day mortality of 14 (9.9%). An ISS of greater than 15 is associated with polytrauma and increased mortality. There were 112 (79.4%) associated cervical fractures. C6 and C7 were both equally the most common locations. There was one symptomatic injury manifesting as a cerebellar ischemic infarct. The degree of arterial injury was classified by the Denver grading scale. There were 61 (43.3%) instances of Denver grade I injuries, followed by grade IV at 36 (25.5%), grade II at 34 (24.1%), grade III at 8 (5.7%), and grade V at 1 (0.7%). The level of injury was recorded as follows: V2 = 67 (47.5%), V3 = 56 (39.7%), V1 = 48 (34%), V4 = 14 (9.9%). Medical therapy included aspirin in 93 patients (66%), 31 patients (22%) received systemic anticoagulation with heparin drip, and 2 patients (1%) were administered therapeutic Lovenox. A total of 15 patients (11%) received no medical treatment. There was one intervention in our series. Our only grade V injury was coil embolized. A total of 118 patients (84%) had follow-up imaging. Seventy-eight patients (96%) with grade I and grade II injuries did not worsen, and complete radiographic resolution was found in 50 patients (62%). Grade IV injuries persisted in 22 patients (75.9%). Median time to resolution for grade I and grade II injuries was 7 and 8 days, respectively. Most follow-up scans for grade I and II injuries occurred within 50 days. Conclusions Posterior circulation stroke due to blunt vertebral artery injury is rare. In our experience, the natural course of blunt vertebral artery injury was benign and neither delay in medical treatment nor choice of antithrombotic had a significant impact on outcomes. In our series, only 3 (3.7%) grade I and II injuries worsened and were without any clinical sequelae. We suggest that routine serial imaging in grade I and II blunt vertebral injuries is not warranted.
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- 2021
44. Frontostriatal White Matter Integrity Relations with 'Cool' and 'Hot' Self-Regulation after Pediatric Traumatic Brain Injury
- Author
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Weihua Fan, Dana M. DeMaster, Candice A. Alfano, Johanna Bick, Jesse T. Fischer, Paul T. Cirino, and Linda Ewing-Cobbs
- Subjects
Male ,Dorsum ,Adolescent ,Traumatic brain injury ,Neuropsychological Tests ,Self-Control ,White matter ,Executive Function ,Brain Injuries, Traumatic ,Humans ,Medicine ,Attention ,Child ,business.industry ,Original Articles ,medicine.disease ,White Matter ,Frontal Lobe ,Diffusion Tensor Imaging ,medicine.anatomical_structure ,nervous system ,Diffusion tensor tractography ,Female ,Neurology (clinical) ,business ,Neuroscience - Abstract
Traumatic brain injury (TBI) produces microstructural damage to white matter pathways connecting neural structures in pre-frontal and striatal regions involved in self-regulation (SR). Dorsal and ventral frontostriatal pathways have been linked to cognitive (“cool”) and emotional (“hot”) SR, respectively. We evaluated the relation of frontostriatal pathway fractional anisotropy (FA) 2 months post-TBI on cool and hot SR assessed 7 months post-TBI. Participants were 8–15 years of age, including children with uncomplicated mild TBI (mTBI; n = 24), more severe TBI (complicated-mild, moderate, severe [cms]TBI; n = 60), and typically developing (TD) children (n = 55). Diffusion tensor tractography was used to map frontostriatal pathways. Cool SR included focused and sustained attention performance, and parent-reported attention, whereas hot SR included risk-taking performance and parent-reported emotional control. Multivariate general linear models showed that children with cmsTBI had greater parent-reported cool and hot SR difficulties and lower dorsal and ventral FA than TD children. Focused attention, risk taking, and emotional control correlated with FA of specific dorsal and ventral pathways; however, only the effect of TBI on focused attention was mediated by integrity of dorsal pathways. Results suggest that frontostriatal FA may serve as a biomarker of risk for SR difficulties or to assess response to interventions targeting SR in pediatric TBI and in broader neurodevelopmental populations.
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- 2021
45. Developmental Alterations in Cortical Organization and Socialization in Adolescents Who Sustained a Traumatic Brain Injury in Early Childhood
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Erin D. Bigler, Hannah M. Lindsey, Marianne Macleod, Mary E. Aitken, Linda Ewing-Cobbs, Linda J. Noble-Haeusslein, Zili D. Chu, Tricia L. Merkley, Elisabeth A. Wilde, Harvey S. Levin, Tracy J. Abildskov, Jill V. Hunter, and Gerri Hanten
- Subjects
Male ,030506 rehabilitation ,Adolescent ,Traumatic brain injury ,Poison control ,Suicide prevention ,Occupational safety and health ,03 medical and health sciences ,0302 clinical medicine ,Brain Injuries, Traumatic ,Injury prevention ,Humans ,Medicine ,Early childhood ,Child ,Cerebral Cortex ,business.industry ,Socialization ,Head injury ,Human factors and ergonomics ,Original Articles ,medicine.disease ,Magnetic Resonance Imaging ,Female ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
This study investigated patterns of cortical organization in adolescents who had sustained a traumatic brain injury (TBI) during early childhood to determine ways in which early head injury may alter typical brain development. Increased gyrification in other patient populations is associated with polymicrogyria and aberrant development, but this has not been investigated in TBI. Seventeen adolescents (mean age = 14.1 ± 2.4) who sustained a TBI between 1–8 years of age, and 17 demographically-matched typically developing children (TDC) underwent a high-resolution, T1-weighted 3-Tesla magnetic resonance imaging (MRI) at 6–15 years post-injury. Cortical white matter volume and organization was measured using FreeSurfer's Local Gyrification Index (LGI). Despite a lack of significant difference in white matter volume, participants with TBI demonstrated significantly increased LGI in several cortical regions that are among those latest to mature in normal development, including left parietal association areas, bilateral dorsolateral and medial frontal areas, and the right posterior temporal gyrus, relative to the TDC group. Additionally, there was no evidence of increased surface area in the regions that demonstrated increased LGI. Higher Vineland-II Socialization scores were associated with decreased LGI in right frontal and temporal regions. The present results suggest an altered pattern of expected development in cortical gyrification in the TBI group, with changes in late-developing frontal and parietal association areas. Such changes in brain structure may underlie cognitive and behavioral deficits associated with pediatric TBI. Alternatively, increased gyrification following TBI may represent a compensatory mechanism that allows for typical development of cortical surface area, despite reduced brain volume.
- Published
- 2021
46. Parent and Adolescent Thoughts About Suicide Risk Screening in Pediatric Outpatient Settings
- Author
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Shayla Sullivant, Andrea Bradley-Ewing, Lisa M. Horowitz, Kathy Goggin, Elizabeth C. Lanzillo, Elizabeth A. Wharff, Laika D. Aguinaldo, and David D. Williams
- Subjects
Adult ,Male ,Parents ,Suicide Prevention ,050103 clinical psychology ,medicine.medical_specialty ,Adolescent ,Suicide rates ,Suicidal Ideation ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Outpatients ,medicine ,Humans ,Mass Screening ,0501 psychology and cognitive sciences ,Child ,Psychiatry ,Suicide Risk ,business.industry ,05 social sciences ,030227 psychiatry ,Suicide ,Psychiatry and Mental health ,Clinical Psychology ,Female ,business - Abstract
Suicide rates among adolescents in the United States continue to climb and many at-risk youths are undetected. Screening for suicidal thoughts has become the primary approach to identify those at risk, but no studies have assessed reactions to its deployment in pediatric outpatient settings. This mixed-method study assessed parents' and adolescents' thoughts about suicide risk screening in non-psychiatric, pediatric outpatient specialty settings.As part of a multi-site measurement validation study, adolescents (
- Published
- 2020
47. Diversity, Race, and Health
- Author
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Altovise Ewing, Bisola Ojikutu, Chanita Hughes-Halbert, Utibe Essien, Keolu Fox, Melissa Davis, Erica T. Warner, Roxana Daneshjou, and Adewole S. Adamson
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Economic growth ,biology ,business.industry ,media_common.quotation_subject ,education ,General Medicine ,Health Status Disparities ,Race and health ,humanities ,Health equity ,Action (philosophy) ,Political science ,Toll ,Health care ,biology.protein ,business ,Delivery of Health Care ,Diversity (politics) ,media_common - Abstract
The events of 2020 threw into stark relief the long-standing inequities in healthcare and the disproportionate toll they exert on communities of color. We asked physicians and scientists to share their experiences in confronting and tackling health disparities, and their Voices highlight the need for concerted and widespread action.
- Published
- 2022
48. Teaching Business and Human Rights During the Pandemic
- Author
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Anthony Ewing, Rachel Chambers, and Meg Roggensack
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Government ,Sociology and Political Science ,Human rights ,business.industry ,media_common.quotation_subject ,Public policy ,Conference call ,Crisis management ,Public relations ,Private sector ,Due diligence ,Political science ,Industrial relations ,Pandemic ,ComputingMilieux_COMPUTERSANDEDUCATION ,Business and International Management ,business ,Law ,media_common - Abstract
The sudden impact of the pandemic on BHR teachers inspired Teaching Forum Co-Director Meg Roggensack to convene a weekly conference call for teachers to share their experiences and support one another Since 17 March, ‘Teaching in the Time of Coronavirus’ has become a regular space for Teaching Forum members to discuss the challenges and opportunities of teaching during the pandemic, and a source of social connection Key issues include: protecting the health of employees and communities;considering the privacy impacts of geolocation tracking and facial recognition;11 addressing the discriminatory impacts of artificial intelligence;assessing potential complicity with government actors;ensuring equitable access to online resources and digital education;and advocating for appropriate government policies to protect public health Teachers can use the pandemic example to address the value of conducting human rights due diligence and adding human rights perspectives to corporate risk and crisis management policies 13 Policy-oriented courses can assess the human rights impacts of governmental pandemic response, with particular attention to pandemic policies affecting the private sector [ ]a critical issue that will gain
- Published
- 2020
49. Have changes in audit standards altered client perceptions of auditors?
- Author
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Marcus M. Doxey and Robert Ewing
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Research design ,050208 finance ,business.industry ,media_common.quotation_subject ,05 social sciences ,Aerospace Engineering ,Analogy ,Accounting ,050201 accounting ,Audit ,Auditor independence ,External auditor ,Perception ,0502 economics and business ,Client perceptions ,Business ,Skepticism ,media_common - Abstract
PurposeChanges in external auditing over four decades motivates a historical investigation of how client employees' perceptions of auditors have changed across this period.Design/methodology/approachThis paper uses a longitudinal quasi-experiment to compare current client employees' perceptions of the auditor with results from 1972.FindingsChanges in client employees' perceptions of the audit, its usefulness and of auditor-client conflict suggest increases in auditor independence. However, this paper also finds that despite decades of efforts to strengthen auditor independence and skepticism, the primary analogy client employees apply to the external auditor remains “consultant”.Practical implicationsThe findings contribute to the discussion of whether regulatory and standard changes in the audit environment have changed aspects of client employees' perceptions of auditors.Originality/valueThe paper contributes by presenting a unique approach to partially replicating a historic study using a quasi-experimental research design.
- Published
- 2020
50. Probabilistic failure rate model of a tidal turbine pitch system
- Author
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Jonathan Shek, Fraser J. Ewing, Claudio Bittencourt Ferreira, and Philipp R. Thies
- Subjects
060102 archaeology ,Renewable Energy, Sustainability and the Environment ,business.industry ,Computer science ,020209 energy ,Probabilistic logic ,Failure rate ,06 humanities and the arts ,02 engineering and technology ,Technology readiness level ,Turbine ,Reliability engineering ,0202 electrical engineering, electronic engineering, information engineering ,Physics of failure ,0601 history and archaeology ,Sensitivity (control systems) ,business ,Tidal power ,Reliability (statistics) - Abstract
Accurate reliability prediction for tidal turbines is challenging due to scarce reliability data. To achieve commercialization, it is widely acknowledged that reductions in maintenance costs are vital and robust component reliability assessments can help drive this. For established technologies, reliability prediction either involves a statistical assessment of historical failure data, or a physics of failure approach based on dedicated accelerated testing. However, for low/mid Technology Readiness Level tidal developers these common approaches are difficult. Thus, developers require a method of making reliability predictions for components in the absence of tidal turbine specific failure data and physical testing results. This paper presents a failure rate model for a tidal turbine pitch system using empirical Physics of Failure equations, with associated uncertainties. Critical component design parameters are determined and their effects on the failure rate investigated via a sensitivity analysis. The modelled failure rate is then compared with wind turbine failure data from a series of turbines. The tidal turbine failure rate is approximately 50% lower, however high reliability requirements mean this is unlikely to be acceptable. The developed model can assist turbine developers in estimating failure rates and determining reliability critical design parameters for the failure critical pitch system.
- Published
- 2020
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