Author: "Errico A" / Topic: business.industry - Searchworks@Jio Institute Digital Library Search Results

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2,409 results on '"Errico A"'

1. Valorisation of agri-food waste and mealworms rearing residues for improving the sustainability of Tenebrio molitor industrial production

Author: Salvatore Dimatteo, Alessandra Verardi, Anna Spagnoletta, Simona Errico, Paola Sangiorgio, and Stefania Moliterni
Subjects: Food waste, Environmental protection, business.industry, Insect Science, Industrial production, Circular economy, Sustainability, Food processing, Novel food, Business, Valorisation, Food Science
Abstract: The challenge of feeding over 9 billion humans by 2050 requires a ‘rethink’ of the current linear food production system. In the view of a circular economy, insects can provide a possible solution to valorise waste to produce new foods and materials, as well as the opportunity to solve some environmental problems. Tenebrio molitor (TM) is the first insect approved by the European Commission as a novel food and widely explored by the research world. Although mass production of TM is still not competitive compared to traditional protein sources, studies and companies in the sector are improving the entire production process to meet the growing need for alternative and sustainable protein foods. The use of food loss and waste to replace commercial feed in TM rearing can improve the economic and environmental sustainability of the production process. Furthermore, the exploitation of the variety of TM-based products can lead to the creation of new value chains and employment opportunities. In this review, we focus on the ability of TM to convert low-value substrates into novel foods and materials, as well as the possibility of using the TM rearing waste to obtain fertilisers and bioproducts, such as chitin and chitosan. TM capacity to degrade plastic waste such as polyethylene and polystyrene, thanks to its highly differentiated gut microbiota, is mentioned. Critical aspects related to sustainability and scaling-up of TM rearing are analysed. Hints on food safety of TM-based products are provided. Therefore, this study is a comprehensive review of TM multifunctionality and, at the same time, identifies possible ways to improve the economic and environmental impact of this insect with a circular economy perspective.
Published: 2022
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2. The economic burden of obesity in Italy

Author: Milena Pavlova, Margherita d'Errico, Federico Spandonaro, Health Services Research, and RS: CAPHRI - R2 - Creating Value-Based Health Care
Subjects: Adult, medicine.medical_specialty, Settore SECS-P/06, Economics, Econometrics and Finance (miscellaneous), Population, Cost-of-illness (COI), Financial Stress, Overweight, Obesity · Cardiovascular diseases (CVD) · Diabetes · Cancer · Cost analysis · Cost-of-illness (COI), Indirect costs, Cost of Illness, Environmental health, medicine, Cost analysis, Humans, Obesity, VALIDITY, education, health care economics and organizations, BARIATRIC SURGERY, education.field_of_study, Health economics, OVERWEIGHT, business.industry, Health Policy, Public health, CARDIOVASCULAR RISK, Diabetes, Health Care Costs, medicine.disease, DEPRESSION, CANCER, SELF-REPORTED WEIGHT, PREVALENCE, Cardiovascular diseases (CVD), Italy, Presenteeism, HEALTH-CARE, ATRIAL-FIBRILLATION, Life expectancy, medicine.symptom, business
Abstract: Background Obesity is a complex health disorder that significantly increases the risk of several chronic diseases, and it has been associated with a 5–20-year decrease in life expectancy. The prevalence of obesity is increasing steadily worldwide and Italy follows this trend with an increase of almost 30% in the adult obese population in the last 3 decades. Previous studies estimated that 2–4% of the total health expenditure in Europe is attributed to obesity and it is projected to double by 2050. Currently, there is a lack of sufficient knowledge on the burden of obesity in Italy and most relevant estimates are derived from international studies. The aim of this study is to estimate the direct and indirect costs of obesity in Italy, taking 2020 as the reference year. Methods Based on data collected from the literature, a quantitative cost-of-illness (COI) study was performed from a societal perspective focussing on the adult obese population (Body Mass Index (BMI) ≥ 30 kg/m2) in Italy. Results The study indicated that the total costs attributable to obesity in Italy amounted to €13.34 billion in 2020 (95% credible interval: €8.99 billion Conclusions Obesity is associated with high direct and indirect costs, and cost-effective prevention programmes are deemed fundamental to contain this public health threat in Italy.
Published: 2022
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3. Brain ischemic injury in COVID‐19‐infected patients: a series of 10 post‐mortem cases

Author: Caterina Giannini, Raffaele Aspide, Guido Frascaroli, Giovanna Cenacchi, Liliana Gabrielli, Antonietta D'Errico, Pietro Cortelli, Carmine Gallo, Viscardo Paolo Fabbri, Tiziana Lazzarotto, Maria Pia Foschini, Mattia Riefolo, Fabbri V.P., Foschini M.P., Lazzarotto T., Gabrielli L., Cenacchi G., Gallo C., Aspide R., Frascaroli G., Cortelli P., Riefolo M., Giannini C., D'Errico A., Fabbri, Viscardo P, Foschini, Maria P, Lazzarotto, Tiziana, Gabrielli, Liliana, Cenacchi, Giovanna, Gallo, Carmine, Aspide, Raffaele, Frascaroli, Guido, Cortelli, Pietro, Riefolo, Mattia, Giannini, Caterina, and D'Errico, Antonietta
Subjects: Male, 0301 basic medicine, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Neurology, Brain Ischemia, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Medicine, Letters to the Editor, Postmortem Change, Letter to the Editor, Aged, SARS-CoV-2, business.industry, General Neuroscience, brain, CoViD-19, SARS-CV-2, COVID-19, virus diseases, Ischemic injury, Middle Aged, 030104 developmental biology, medicine.anatomical_structure, Immunology, Female, Autopsy, Neurology (clinical), business, 030217 neurology & neurosurgery, Human, Respiratory tract
Abstract: The coronavirus disease 2019 (COVID‐19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). COVID‐19 symptoms are not limited to the respiratory tract, but complications have been described involving other organs including brain. At present, data on SARS‐CoV‐2 neuropathological features are limited [4, 5, 8, 10] and most frequently focused on cases presenting neurological symptoms.
Published: 2020
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4. Ileal inflammatory pseudotumor in adolescent male patient with prior Burkitt lymphoma: A challenging diagnosis

Author: Alberto Cuocolo, Maria Elena Errico, Nicoletta Marra, Dalila De Lucia, Adriana D'Antonio, Salvatore Buffardi, Ciro Mainolfi, Gaia Mango, Mainolfi, Ciro Gabriele, D'Antonio, Adriana, Mango, Gaia, De Lucia, Dalila, Buffardi, Salvatore, Marra, Nicoletta, Errico, Maria Elena, and Cuocolo, Alberto
Subjects: medicine.medical_specialty, Positron emission tomography/computed tomography, R895-920, Molecular imaging, Case Report, Asymptomatic, 030218 nuclear medicine & medical imaging, Inflammatory pseudotumor, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, 0302 clinical medicine, medicine, Radiology, Nuclear Medicine and imaging, Fever of unknown origin, medicine.diagnostic_test, business.industry, Histopathological analysis, Burkitt lymphoma, medicine.disease, Lymphoma, stomatognathic diseases, Positron emission tomography, Male patient, Radiology, 18F-fluorodeoxyglucose, medicine.symptom, business, 030217 neurology & neurosurgery, Rare disease
Abstract: Inflammatory pseudotumor is a rare benign mesenchymal pediatric neoplasm, that can mimic tumoral residue or relapse at metabolic imaging with nonspecific clinical presentation and difficult diagnosis. We present the case of a 14year old male patient with fever of unknown origin and large ileal mass, diagnosed with and treated for Burkitt lymphoma, who performed several 18-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scans, during and after first line chemotherapy, showing persistent and focal uptake, while ileal mass volume decreased dramatically and the patient was clinically asymptomatic. Histopathological analysis of residual ileal mass was suggestive for xanthomatous pseudotumor, a type of inflammatory pseudotumor. No more treatment was performed and a short-term follow up with 18F-FDG PET/CT showed tracer uptake intensity decreasing progressively over the next few months. This case reports an uncommon presentation of a rare disease, inflammatory pseudotumor of the small bowel developed at the site of treated Burkitt lymphoma, underscoring the potential role of 18F-FDG PET/CT imaging in the diagnosis and management of these rare neoplasms, particularly in asymptomatic patients.
Published: 2021
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5. The treatment of intertrochanteric fracture: a survey on the preferred treatment used by orthopedic surgeons in Campania

Author: Giuseppe Toro, Giacomo Errico, G. Bruno, Achille Pellegrino, Antonio Medici, Raffaele Pezzella, Pezzella, Raffaele, Toro, Giuseppe, Errico, Giacomo, Pellegrino, Achille, Medici, Antonio, and Bruno, Gaetano
Subjects: musculoskeletal diseases, Trochanteric fractures, medicine.medical_specialty, business.industry, Dentistry, law.invention, Intramedullary rod, law, Hip replacement, Orthopedic surgery, Medicine, Intertrochanteric fracture, business, Fixation (histology)
Abstract: Hip fragility fractures incidence is constantly increasing, and outcomes are mostly poor in terms of both morbidity and mortality. Surgery is the treatment of choice for most hip fractures, but the choice between the various fixation devices is difficult. We conducted a survey on the treatment of trochanteric fractures among orthopedic surgeons in Campania using a Google form questionnaire. The preferred treatment was cephalomedullary distal locked nailing for most fractures, while sliding hip screws and hip replacement were limited to 31 A1.2 and 31.B2 fractures.
Published: 2021
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6. Increasing the Astrophysical Reach of the Advanced Virgo Detector via the Application of Squeezed Vacuum States of Light

Author: Acernese, F, Agathos, M, Aiello, L, Allocca, A, Amato, A, Ansoldi, S, Antier, S, Arene, M, Arnaud, N, Ascenzi, S, Astone, P, Aubin, F, Babak, S, Bacon, P, Badaracco, F, Bader, M. K. M, Baird, J, Baldaccini, F, Ballardin, G, Baltus, G, Barbieri, C, Barneo, P, Barone, F, Barsuglia, M, Barta, D, Basti, A, Bawaj, M, Bazzan, M, Bejger, M, Belahcene, I and Bernuzzi, S, Bersanetti, D, Bertolini, A, Bischi, M, Bitossi, M, Bizouard, M. A, Bobba, F, Boer, M, Bogaert, G, Bondu, F, Bonnand, R, Boom, B. A, Boschi, V and Bouffanais, Y, Bozzi, A, Bradaschia, C, Branchesi, M, Breschi, M, Briant, T, Brighenti, F, Brillet, A, Brooks, J, Bruno, G, Bulik, T, Bulten, H. J, Buskulic, D, Cagnoli, G, Calloni, E, Canepa, M, Carapella, G, Carbognani, F, Carullo, G, Diaz, Casanueva and Casentini, J., C, Castaneda, J, Caudill, S, Cavalier, F, Cavalieri, R, Cella, G, Cerda-Duran, P, Cesarini, E, Chaibi, O, Chassande-Mottin, E, Chiadini, F, Chierici, R, Chincarini, A, Chiummo, A, Christensen, N, Chua, S, Ciani, G, Ciecielag, P, Cieslar, M, Ciolfi, R, Cipriano, F, Cirone, A, Clesse, S, Cleva, F, Coccia, E, Cohadon, P-F and Cohen, D, Colpi, M, Conti, L, Cordero-Carrion, I and Corezzi, Corre, D, Cortese, S, Coulon, J-P and Croquette, M, Cudell, J-R and Cuoco, E, Curylo, M, D'Angelo, B, D'Antonio, S, Dattilo, V and Davier, Degallaix, J, De Laurentis, M, Deleglise, S, Del Pozzo, W, De Pietri, R, De Rosa, R, De Rossi, C, Dietrich, T, Di Fiore, L, Di Giorgio, C, Di Giovanni, F, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Di Pace, S, Palma, Di, I and Di Renzo, F, Drago, M, Ducoin, J-G and Durante, O, D'Urso, D, Eisenmann, M, Errico, L, Estevez, D, Fafone, V and Farinon, Feng, F, Fenyvesi, E, Ferrante, I and Fidecaro, Fiori, I and Fiorucci, Fittipaldi, R, Fiumara, V and Flaminio, R, Font, J. A, Fournier, J-D and Frasca, Frasconi, F, Frey, V and Fronze, G, Garufi, F, Gemme, G, Genin, E, Gennai, A, Ghosh, Archisman and Giacomazzo, B, Gosselin, M, Gouaty, R, Grado, A, Granata, M, Greco, G, Grignani, G, Grimaldi, A, Grimm, S. J, Gruning, P, Guidi, G. M, Guixe, G, Guo, Y, Gupta, P, Halim, O, Harder, T, Harms, J, Heidmann, A, Heitmann, H, Hello, P, Hemming, G, Hennes, E, Hinderer, T, Hofman, D, Huet, D, Hui, V and Idzkowski, Iess, A, Intini, G, Isac, J-M and Jacqmin, T, Jaranowski, P, Jonker, R. J. G, Katsanevas, S, Kefelian, F, Khan, I and Khetan, N, Koekoek, G, Koley, S, Krolak, A, Kutynia, A, Laghi, D, Lamberts, A, Rosa, La, I and Lartaux-Vollard, A, Lazzaro, C, Leaci, P, Leroy, N, Letendre, N, Linde, F, Llorens-Monteagudo, M, Longo, A, Lorenzini, M, Loriette, V and Losurdo, Lumaca, D, Macquet, A, Majorana, E, Maksimovic, I and Man, Mangano, V and Mantovani, Mapelli, M, Marchesoni, F, Marion, F, Marquina, A, Marsat, S, Martelli, F, Martinez, V and Masserot, Mastrogiovanni, S, Villa, Mejuto and Mereni, E., L, Merzougui, M, Metzdorff, R, Miani, A, Michel, C, Milano, L, Miller, A, Milotti, E, Minazzoli, O, Minenkov, Y, Montani, M, Morawski, F, Mours, B, Muciaccia, F, Nagar, A, Nardecchia, I and Naticchioni, Neilson, J, Nelemans, G, Nguyen, C, Nichols, D, Nissanke, S, Nocera, F, Oganesyan, G, Olivetto, C, Pagano, G, Pagliaroli, G, Palomba, C, Pang, P. T. H, Pannarale, F, Paoletti, F, Paoli, A, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patricelli, B, Perego, A, Pegoraro, M, Perigois, C, Perreca, A, Perries, S, Phukon, K. S, Piccinni, O. J, Pichot, M, Piendibene, M, Piergiovanni, F, Pierro, V and Pillant, Pinard, L, Pinto, I. M, Piotrzkowski, K, Plastino, W, Poggiani, R, Popolizio, P, Porter, E. K, Prevedelli, M, Principe, M, Prodi, G. A, Punturo, M, Puppo, P, Raaijmakers, G, Radulesco, N, Rapagnani, P, Razzano, M, Regimbau, T, Rei, L, Rettegno, P, Ricci, F, Riemenschneider, G, Robinet, F, Rocchi, A, Rolland, L, Romanelli, M, Romano, R, Rosiska, D, Ruggi, P, Salafia, O. S, Salconi, L, Samajdar, A, Sanchis-Gual, N, Santos, E, Sassolas, B, Sauter, O, Sayah, S, Sentenac, D, Sequino, V and Sharma, Sieniawska, M, Singh, N, Singhal, A, Sipala, V and Sordini, V and Sorrentino, Spera, M, Stachie, C, Steer, D. A, Stratta, G, Sur, A, Swinkels, B. L, Tacca, M, Tanasijczuk, A. J, San, Martin, Tapia and Tiwari, E. N., Tonelli, M, Torres-Forne, A, Melo, I. Tosta E, Travasso, F, Tringali, M. C, Trovato, A, Tsang, K. W, Turconi, M, Valentini, M, van Bakel, N, van Beuzekom, M, van den Brand, J. F. J, Van Den Broeck, C, van der Schaaf, L, Vardaro, M, Vasuth, M, Vedovato, G, Verkindt, D, Vetrano, F, Vicere, A, Vinet, J-Y and Vocca, H, Walet, R, Was, M, Zadrozny, A, Zelenova, T, Zendri, J-P and Vahlbruch, Henning and Mehmet, Moritz and Lueck, Harald and Danzmann, Karsten and Virgo Collaboration, UCL - SST/IRMP - Institut de recherche en mathématique et physique, Acernese, F, Agathos, M, Aiello, L, Allocca, A, Amato, A, Ansoldi, S, Antier, S, Arene, M, Arnaud, N, Ascenzi, S, Astone, P, Aubin, F, Babak, S, Bacon, P, Badaracco, F, Bader, M, Baird, J, Baldaccini, F, Ballardin, G, Baltus, G, Barbieri, C, Barneo, P, Barone, F, Barsuglia, M, Barta, D, Basti, A, Bawaj, M, Bazzan, M, Bejger, M, Belahcene, I, Bernuzzi, S, Bersanetti, D, Bertolini, A, Bischi, M, Bitossi, M, Bizouard, M, Bobba, F, Boer, M, Bogaert, G, Bondu, F, Bonnand, R, Boom, B, Boschi, V, Bouffanais, Y, Bozzi, A, Bradaschia, C, Branchesi, M, Breschi, M, Briant, T, Brighenti, F, Brillet, A, Brooks, J, Bruno, G, Bulik, T, Bulten, H, Buskulic, D, Cagnoli, G, Calloni, E, Canepa, M, Carapella, G, Carbognani, F, Carullo, G, Casanueva Diaz, J, Casentini, C, Castaneda, J, Caudill, S, Cavalier, F, Cavalieri, R, Cella, G, Cerda-Duran, P, Cesarini, E, Chaibi, O, Chassande-Mottin, E, Chiadini, F, Chierici, R, Chincarini, A, Chiummo, A, Christensen, N, Chua, S, Ciani, G, Ciecielag, P, Cieslar, M, Ciolfi, R, Cipriano, F, Cirone, A, Clesse, S, Cleva, F, Coccia, E, Cohadon, P, Cohen, D, Colpi, M, Conti, L, Cordero-Carrion, I, Corezzi, S, Corre, D, Cortese, S, Coulon, J, Croquette, M, Cudell, J, Cuoco, E, Curylo, M, D'Angelo, B, D'Antonio, S, Dattilo, V, Davier, M, Degallaix, J, De Laurentis, M, Deleglise, S, Del Pozzo, W, De Pietri, R, De Rosa, R, De Rossi, C, Dietrich, T, Di Fiore, L, Di Giorgio, C, Di Giovanni, F, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Di Pace, S, Di Palma, I, Di Renzo, F, Drago, M, Ducoin, J, Durante, O, D'Urso, D, Eisenmann, M, Errico, L, Estevez, D, Fafone, V, Farinon, S, Feng, F, Fenyvesi, E, Ferrante, I, Fidecaro, F, Fiori, I, Fiorucci, D, Fittipaldi, R, Fiumara, V, Flaminio, R, Font, J, Fournier, J, Frasca, S, Frasconi, F, Frey, V, Fronze, G, Garufi, F, Gemme, G, Genin, E, Gennai, A, Ghosh, A, Giacomazzo, B, Gosselin, M, Gouaty, R, Grado, A, Granata, M, Greco, G, Grignani, G, Grimaldi, A, Grimm, S, Gruning, P, Guidi, G, Guixe, G, Guo, Y, Gupta, P, Halim, O, Harder, T, Harms, J, Heidmann, A, Heitmann, H, Hello, P, Hemming, G, Hennes, E, Hinderer, T, Hofman, D, Huet, D, Hui, V, Idzkowski, B, Iess, A, Intini, G, Isac, J, Jacqmin, T, Jaranowski, P, Jonker, R, Katsanevas, S, Kefelian, F, Khan, I, Khetan, N, Koekoek, G, Koley, S, Krolak, A, Kutynia, A, Laghi, D, Lamberts, A, La Rosa, I, Lartaux-Vollard, A, Lazzaro, C, Leaci, P, Leroy, N, Letendre, N, Linde, F, Llorens-Monteagudo, M, Longo, A, Lorenzini, M, Loriette, V, Losurdo, G, Lumaca, D, Macquet, A, Majorana, E, Maksimovic, I, Man, N, Mangano, V, Mantovani, M, Mapelli, M, Marchesoni, F, Marion, F, Marquina, A, Marsat, S, Martelli, F, Martinez, V, Masserot, A, Mastrogiovanni, S, Mejuto Villa, E, Mereni, L, Merzougui, M, Metzdorff, R, Miani, A, Michel, C, Milano, L, Miller, A, Milotti, E, Minazzoli, O, Minenkov, Y, Montani, M, Morawski, F, Mours, B, Muciaccia, F, Nagar, A, Nardecchia, I, Naticchioni, L, Neilson, J, Nelemans, G, Nguyen, C, Nichols, D, Nissanke, S, Nocera, F, Oganesyan, G, Olivetto, C, Pagano, G, Pagliaroli, G, Palomba, C, Pang, P, Pannarale, F, Paoletti, F, Paoli, A, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patricelli, B, Perego, A, Pegoraro, M, Perigois, C, Perreca, A, Perries, S, Phukon, K, Piccinni, O, Pichot, M, Piendibene, M, Piergiovanni, F, Pierro, V, Pillant, G, Pinard, L, Pinto, I, Piotrzkowski, K, Plastino, W, Poggiani, R, Popolizio, P, Porter, E, Prevedelli, M, Principe, M, Prodi, G, Punturo, M, Puppo, P, Raaijmakers, G, Radulesco, N, Rapagnani, P, Razzano, M, Regimbau, T, Rei, L, Rettegno, P, Ricci, F, Riemenschneider, G, Robinet, F, Rocchi, A, Rolland, L, Romanelli, M, Romano, R, Rosinska, D, Ruggi, P, Salafia, O, Salconi, L, Samajdar, A, Sanchis-Gual, N, Santos, E, Sassolas, B, Sauter, O, Sayah, S, Sentenac, D, Sequino, V, Sharma, A, Sieniawska, M, Singh, N, Singhal, A, Sipala, V, Sordini, V, Sorrentino, F, Spera, M, Stachie, C, Steer, D, Stratta, G, Sur, A, Swinkels, B, Tacca, M, Tanasijczuk, A, Tapia San Martin, E, Tiwari, S, Tonelli, M, Torres-Forne, A, Tosta E Melo, I, Travasso, F, Tringali, M, Trovato, A, Tsang, K, Turconi, M, Valentini, M, Van Bakel, N, Van Beuzekom, M, Van Den Brand, J, Van Den Broeck, C, Van Der Schaaf, L, Vardaro, M, Vasuth, M, Vedovato, G, Verkindt, D, Vetrano, F, Vicere, A, Vinet, J, Vocca, H, Walet, R, Was, M, Zadrozny, A, Zelenova, T, Zendri, J, Vahlbruch, H, Mehmet, M, Luck, H, Danzmann, K, Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Collège de France (CdF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, ESPCI ParisTech, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut des Hautes Etudes Scientifiques (IHES), IHES, Virgo, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Acernese, F., Agathos, M., Aiello, L., Allocca, A., Amato, A., Ansoldi, S., Antier, S., Arène, M., Arnaud, N., Ascenzi, S., Astone, P., Aubin, F., Babak, S., Bacon, P., Badaracco, F., Bader, M. K. M., Baird, J., Baldaccini, F., Ballardin, G., Baltus, G., Barbieri, C., Barneo, P., Barone, F., Barsuglia, M., Barta, D., Basti, A., Bawaj, M., Bazzan, M., Bejger, M., Belahcene, I., Bernuzzi, S., Bersanetti, D., Bertolini, A., Bischi, M., Bitossi, M., Bizouard, M. A., Bobba, F., Boer, M., Bogaert, G., Bondu, F., Bonnand, R., Boom, B. A., Boschi, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Branchesi, M., Breschi, M., Briant, T., Brighenti, F., Brillet, A., Brooks, J., Bruno, G., Bulik, T., Bulten, H. J., Buskulic, D., Cagnoli, G., Calloni, E., Canepa, M., Carapella, G., Carbognani, F., Carullo, G., Casanueva Diaz, J., Casentini, C., Castañeda, J., Caudill, S., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, O., Chassande-Mottin, E., Chiadini, F., Chierici, R., Chincarini, A., Chiummo, A., Christensen, N., Chua, S., Ciani, G., Ciecielag, P., Cieślar, M., Ciolfi, R., Cipriano, F., Cirone, A., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D., Colpi, M., Conti, L., Cordero-Carrión, I., Corezzi, S., Corre, D., Cortese, S., Coulon, J. -P., Croquette, M., Cudell, J. -R., Cuoco, E., Curylo, M., D’Angelo, B., D’Antonio, S., Dattilo, V., Davier, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Pozzo, W., De Pietri, R., De Rosa, R., De Rossi, C., Dietrich, T., Di Fiore, L., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Di Pace, S., Di Palma, I., Di Renzo, F., Drago, M., Ducoin, J. -G., Durante, O., D’Urso, D., Eisenmann, M., Errico, L., Estevez, D., Fafone, V., Farinon, S., Feng, F., Fenyvesi, E., Ferrante, I., Fidecaro, F., Fiori, I., Fiorucci, D., Fittipaldi, R., Fiumara, V., Flaminio, R., Font, J. A., Fournier, J. -D., Frasca, S., Frasconi, F., Frey, V., Fronzè, G., Garufi, F., Gemme, G., Genin, E., Gennai, A., Ghosh, Archisman, Giacomazzo, B., Gosselin, M., Gouaty, R., Grado, A., Granata, M., Greco, G., Grignani, G., Grimaldi, A., Grimm, S. J., Gruning, P., Guidi, G. M., Guixé, G., Guo, Y., Gupta, P., Halim, O., Harder, T., Harms, J., Heidmann, A., Heitmann, H., Hello, P., Hemming, G., Hennes, E., Hinderer, T., Hofman, D., Huet, D., Hui, V., Idzkowski, B., Iess, A., Intini, G., Isac, J. -M., Jacqmin, T., Jaranowski, P., Jonker, R. J. G., Katsanevas, S., Kéfélian, F., Khan, I., Khetan, N., Koekoek, G., Koley, S., Królak, A., Kutynia, A., Laghi, D., Lamberts, A., La Rosa, I., Lartaux-Vollard, A., Lazzaro, C., Leaci, P., Leroy, N., Letendre, N., Linde, F., Llorens-Monteagudo, M., Longo, A., Lorenzini, M., Loriette, V., Losurdo, G., Lumaca, D., Macquet, A., Majorana, E., Maksimovic, I., Man, N., Mangano, V., Mantovani, M., Mapelli, M., Marchesoni, F., Marion, F., Marquina, A., Marsat, S., Martelli, F., Martinez, V., Masserot, A., Mastrogiovanni, S., Mejuto Villa, E., Mereni, L., Merzougui, M., Metzdorff, R., Miani, A., Michel, C., Milano, L., Miller, A., Milotti, E., Minazzoli, O., Minenkov, Y., Montani, M., Morawski, F., Mours, B., Muciaccia, F., Nagar, A., Nardecchia, I., Naticchioni, L., Neilson, J., Nelemans, G., Nguyen, C., Nichols, D., Nissanke, S., Nocera, F., Oganesyan, G., Olivetto, C., Pagano, G., Pagliaroli, G., Palomba, C., Pang, P. T. H., Pannarale, F., Paoletti, F., Paoli, A., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Perego, A., Pegoraro, M., Périgois, C., Perreca, A., Perriès, S., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Piotrzkowski, K., Plastino, W., Poggiani, R., Popolizio, P., Porter, E. K., Prevedelli, M., Principe, M., Prodi, G. A., Punturo, M., Puppo, P., Raaijmakers, G., Radulesco, N., Rapagnani, P., Razzano, M., Regimbau, T., Rei, L., Rettegno, P., Ricci, F., Riemenschneider, G., Robinet, F., Rocchi, A., Rolland, L., Romanelli, M., Romano, R., Rosińska, D., Ruggi, P., Salafia, O. S., Salconi, L., Samajdar, A., Sanchis-Gual, N., Santos, E., Sassolas, B., Sauter, O., Sayah, S., Sentenac, D., Sequino, V., Sharma, A., Sieniawska, M., Singh, N., Singhal, A., Sipala, V., Sordini, V., Sorrentino, F., Spera, M., Stachie, C., Steer, D. A., Stratta, G., Sur, A., Swinkels, B. L., Tacca, M., Tanasijczuk, A. J., Tapia San Martin, E. N., Tiwari, S., Tonelli, M., Torres-Forné, A., Tosta e Melo, I., Travasso, F., Tringali, M. C., Trovato, A., Tsang, K. W., Turconi, M., Valentini, M., van Bakel, N., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., van der Schaaf, L., Vardaro, M., Vasúth, M., Vedovato, G., Verkindt, D., Vetrano, F., Viceré, A., Vinet, J. -Y., Vocca, H., Walet, R., Was, M., Zadrożny, A., Zelenova, T., Zendri, J. -P., Vahlbruch, Henning, Mehmet, Moritz, Lück, Harald, Danzmann, Karsten, IoP (FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Other Research IHEF (IoP, FNWI), Spectroscopies optiques des matériaux verres, amorphes et à nanoparticules (SOPRANO), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Annecy de Physique des Particules (LAPP), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut des Hautes Études Scientifiques (IHES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Arene, M., Castaneda, J., Cerda-Duran, P., Cieslar, M., Cordero-Carrion, I., D'Angelo, B., D'Antonio, S., Deleglise, S., D'Urso, D., Fronze, G., Ghosh, A., Guixe, G., Kefelian, F., Krolak, A., Perigois, C., Perries, S., Rosinska, D., Torres-Forne, A., Tosta E Melo, I., Van Bakel, N., Van Beuzekom, M., Van Den Brand, J. F. J., Van Der Schaaf, L., Vasuth, M., Vicere, A., Zadrozny, A., Vahlbruch, H., Mehmet, M., Luck, H., Danzmann, K., (Astro)-Particles Physics, Virgo Collaboration, Cohadon, P.-F., Coulon, J.-P., Cudell, J.-R., Ducoin, J.-G., Fournier, J.-D., Isac, J.-M., Vinet, J.-Y., and Zendri, J.-P.
Subjects: neutron star: binary, Gravitational waves detection, General Physics and Astronomy, 01 natural sciences, vacuum state, NOISE, interferometric detector, LIGO, noise: quantum, gravitational waves, squeezing, vacuum, Settore FIS/01, Physics, Quantum optics, Quantum limit, Quantum noise, Detector, Physical Sciences, gravitational waves, squeezed light, interferometric detectors, Gravitational wave, Squeezed coherent state, Physics, Multidisciplinary, squeezed state, Gravitation and Astrophysics, horizon, Gravitational waves, General Relativity and Quantum Cosmology, Optics, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], SDG 7 - Affordable and Clean Energy, 010306 general physics, enhancement, Astrophysique, Science & Technology, business.industry, Shot noise, gravitational radiation, gravitational waves, thermal noise, sensitivity, detector: sensitivity, Quantum technology, Automatic Keywords, VIRGO, injection, Physics and Astronomy, gravitational radiation detector: interferometer, noise, WAVE, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], gravitational waves, nonlinear optics, quantum optics
Abstract: Current interferometric gravitational-wave detectors are limited by quantum noise over a wide range of their measurement bandwidth. One method to overcome the quantum limit is the injection of squeezed vacuum states of light into the interferometer's dark port. Here, we report on the successful application of this quantum technology to improve the shot noise limited sensitivity of the Advanced Virgo gravitational-wave detector. A sensitivity enhancement of up to 3.2±0.1 dB beyond the shot noise limit is achieved. This nonclassical improvement corresponds to a 5%-8% increase of the binary neutron star horizon. The squeezing injection was fully automated and over the first 5 months of the third joint LIGO-Virgo observation run O3 squeezing was applied for more than 99% of the science time. During this period several gravitational-wave candidates have been recorded., 0, info:eu-repo/semantics/published
Published: 2019
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7. Low GFR amplifies the association between coronary three-vessel disease and all-cause mortality

Author: Antonio Mirijello, Massimiliano Copetti, Maria Maddalena D’Errico, Roberto Pontremoli, Salvatore De Cosmo, M P Salvatori, Nicola Marchese, Gianluigi Vendemiale, Carlo Vigna, Mariateresa Santoliquido, and Pamela Piscitelli
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Medicine (miscellaneous), Renal function, Coronary Artery Disease, Disease, Coronary Angiography, Coronary artery disease, chemistry.chemical_compound, Risk Factors, Internal medicine, medicine, Humans, Renal Insufficiency, Chronic, Risk factor, education, Aged, education.field_of_study, Creatinine, Nutrition and Dietetics, business.industry, Middle Aged, Prognosis, medicine.disease, chemistry, Cohort, Cardiology, Cardiology and Cardiovascular Medicine, business, Glomerular Filtration Rate, Kidney disease
Abstract: Background and aim Three vessels disease (3VD) has been associated with worse prognosis and higher mortality. Chronic kidney disease (CKD) is an independent risk factor for premature death, mostly due to coronary artery disease (CAD). We aim to examine the prognostic impact of 3VD on all-cause mortality in a cohort of high cardiovascular risk subjects undergoing coronary angiography (CA) and to explore whether low eGFR ( Methods and results One-thousand-seventeen subjects (759M, mean age 68.4 + 11 years) consecutive subjects undergoing CA from 2016 to 2018 were evaluated. Subjects were classified according to the severity of CAD as follows: group “three vessels disease” (3VD), and “no three vessels disease” (No 3VD). Serum creatinine was measured to estimate glomerular filtration rate (eGFR). The whole population was divided into 4 groups (A, B, C, D), according to the presence/absence of low eGFR and/or 3VD. One-hundred-fourteen deaths occurred (median follow-up:44 months). The risk of death in subjects with 3VD was almost 2-time higher than subject without 3VD (adjusted HR= 1.61; 95% CI 1.094-2.373, p= 0.0157). Among 4 subgroups, subjects with low eGFR and 3VD (Group D) had the highest risk of death (adjusted HR=3.881; 95% CI 2.256-6.676, p Conclusions Low eGFR significantly amplifies the risk of all-cause mortality associated to 3VD. Our results strengthen the role of kidney disease as a risk multiplier for cardiovascular and all-cause mortality and highlight the need to prevent its onset and progression.
Published: 2022
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8. Pseudoaneurysm of the aortic root following aortic valve endocarditis - a case with 2 rare life - threatening complications

Author: Paola Leomanni, Salvatore Masala, Alessandra Luciano, Leonardo Benelli, Luigi Spiritigliozzi, Cecilia Cerimele, Luca Pugliese, Francesco Garaci, Matteo Cesareni, Gianluca Vanni, Roberto Floris, Francesco Paolo Sbordone, Mario Laudazi, Martina Cerocchi, Carlo Di Donna, Carlotta Rellini, Francesca D'Errico, Federica Di Tosto, Francesco Grimaldi, Lucrezia Caterino, Vincenzo De Stasio, Marcello Chiocchi, and Monia Pasqualetto
Subjects: medicine.medical_specialty, Fistula, R895-920, Case Report, Pseudoaneurysm, Medical physics. Medical radiology. Nuclear medicine, Aortic valve replacement, medicine.artery, Coronary computed tomography angiography, Medicine, Endocarditis, Ventricular outflow tract, Valvular annulus, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Abscess, business.industry, medicine.disease, Surgery, Right coronary artery, Infective endocarditis, cardiovascular system, business
Abstract: Infective endocarditis can have peri-annular spread and involve the valvular annulus and adjacent cardiac structures, leading to tissue necrosis and peri-annular abscess. This process may cause pseudoaneurysm formation and other rare and potentially life-threatening complications, so their identification and correct diagnosis are crucial. We describe a case of an 81-year-old woman, with a history of aortic valve replacement and worsening of symptoms, that presents at the imaging a pseudoaneurysm of the aortic root complicated at the same time by 2 life-threatening conditions: fistulization in the Right Ventricular Outflow Tract (RVOT) and the compression of Right Coronary Artery (RCA). This case underlines the importance of imaging, especially Coronary Computed Tomography Angiography (CCTA), in the diagnosis and follow-up of infective endocarditis and its complications, especially in a patient not eligible for surgery.
Published: 2021
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9. Characterization of Contractile Forces Generated by Stretch Marks Fibroblasts: In Vitro Study

Author: Umberto Rega, Francesco D'Andrea, Concetta Errico, Paolo Persichetti, Jean Paul Meningaud, Rosita Pensato, Simone La Padula, Chiara Pizza, Barbara Hersant, Pensato, R., Hersant, B., Pizza, C., Errico, C., D'Andrea, F., Rega, U., Persichetti, P., Meningaud, J. P., and La Padula, S.
Subjects: Contraction (grammar), business.industry, Fibroblasts, Matrix (biology), Collagen lattice, Ascorbic acid, medicine.disease, Stretch mark, medicine.anatomical_structure, Stretch marks, medicine, Biophysics, Fibroblast, Humans, Striae distensae, In vitro study, Surgery, Collagen, Platelet rich plasma, medicine.symptom, Striae Distensae, business, Muscle Contraction
Abstract: Authors present a study about the contraction forces observed in striae distensae fibroblasts (SMF) in a collagen scaffold. Collagen lattices were used to study the mechanical behavior of SDF within the collagen matrix compared to the lattices produced using the healthy skin derived fibroblasts (NSF). A Forcebox device was used to measure the contractile forces. Striae Rubrae fibroblast’s contractile force was by 28% greater than that generated by the NSF and striae albae fibroblasts (P
Published: 2021
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10. Usage of Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 in the Treatment of the Patient with Black Stains

Author: Marcello Maddalone, Edoardo Bianco, Greta D’Errico, Elena Tregambi, D'Errico, G, Bianco, E, Tregambi, E, and Maddalone, M
Subjects: Lactobacillu, Periodontitis, biology, Occlusion, business.industry, Periodontiti, Probiotic, medicine.disease, biology.organism_classification, Microbiology, law.invention, Lactobacillus reuteri, Black stain, law, Lactobacillus, medicine, business, General Dentistry, Caries prevention
Abstract: Aim: This pilot study aimed to evaluate the effectiveness of an oral probiotic, Lactobacillus reuteri DSM 17938 and L. reuteri ATCC PTA 5289 (ProDentis®, BioGaia), to avoid the recurrence of black stains (BS) in children and young adults. The purpose of this work is also to propose an oral hygiene protocol that could hinder or slow down the formation of these pigments. Materials and methods: Twenty patients aged between 8 years and 24 years with extrinsic pigmentations on one or more dental elements and with black lines attributable to chromogenic bacteria were divided into two groups randomly: the first (group I with 10 patients, test group) received a professional oral hygiene session and a therapy with a probiotic food supply containing L. reuteri for a duration of 2 months. The second group (group II with 10 patients, control group) received only a professional oral hygiene session. Data were collected using the Lobene modified index. Results: The mean Lobene index is lower in the test group compared to the control group after both 1 and 2 months from the beginning of the treatment. Conclusion: Black stain formation could be prevented by administering an L. reuteri-based probiotic food supply. Clinical significance: The use of probiotics is a relatively undeveloped strategy for the prevention and treatment of BS.
Published: 2021
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11. Letermovir prophylaxis in T-cell–depleted transplants: breakthrough and rebound infections in the postmarketing setting

Author: Eleni Tholouli, Ben Carpenter, Kirsty Thomson, Sara Lozano, Antonio Pagliuca, Adrian Bloor, Amy Publicover, Anne Parker, Gerardo Errico, Kim Orchard, Anjum Khan, Varun Mehra, Karl S. Peggs, Maria A V Marzolini, Emma Nicholson, Jennifer Pirrie, Nick Duncan, Philip Crea, Erin Hurst, John A. Snowden, Jennifer Byrne, Richard Lovell, and Maria H. Gilleece
Subjects: Adult, Male, T-Lymphocytes, T cell, Cytomegalovirus, Acetates, Disease-Free Survival, Young Adult, Letermovir, Research Letter, medicine, Humans, Lymphocyte Count, Aged, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Phenotype, medicine.anatomical_structure, Cytomegalovirus Infections, Multivariate Analysis, Immunology, Linear Models, Quinazolines, Female, Virus Activation, business, medicine.drug
Abstract: Decreased cytomegalovirus (CMV)-specific immunity after hematopoietic cell transplantation (HCT) is associated with late CMV reactivation and increased mortality. Whether letermovir prophylaxis-associated reduction in viral exposure influences CMV-specific immune reconstitution is unknown. In a prospective cohort of allogeneic HCT recipients who received letermovir, we compared polyfunctional CMV-specific T-cell responses to those of controls who received PCR-guided preemptive therapy before the introduction of letermovir. Thirteen-color flow cytometry was used to assess T-cell responses at 3 months after HCT following stimulation with CMV immediate early-1 (IE-1) antigen and phosphoprotein 65 (pp65) antigens. Polyfunctionality was characterized by combinatorial polyfunctionality analysis of antigen-specific T-cell subsets. Use of letermovir and reduction of viral exposure were assessed for their association with CMV-specific T-cell immunity. Polyfunctional T-cell responses to IE-1 and pp65 were decreased in letermovir recipients and remained diminished after adjustment for donor CMV serostatus, absolute lymphocyte count, and steroid use. Among letermovir recipients, greater peak CMV DNAemia and increased viral shedding were associated with stronger CD8+ responses to pp65, whereas the CMV shedding rate was associated with greater CD4+ responses to IE-1. In summary, our study provided initial evidence that letermovir may delay CMV-specific cellular reconstitution, possibly related to decreased CMV antigen exposure. Evaluating T-cell polyfunctionality may identify patients at risk for late CMV infection after HCT.
Published: 2021
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12. Synthetic Cannabinoids and Cathinones Cardiotoxicity: Facts and Perspectives

Author: Davide Radaelli, Paolo Frisoni, Alessandro Manfredi, Paolo Fattorini, Stefano D'Errico, Margherita Neri, Martina Zanon, and Matteo Scopetti
Subjects: Cannabinoid receptor, Synthetic cannabinoids, Pharmacology, NO, Alkaloids, Atp depletion, Khat, medicine, Cardiotoxicity, Myocardial damage, New psychoactive substances, Synthetic cathinones, Toxicity, Humans, Pharmacology (medical), Convention on Psychotropic Substances, Psychotropic Drugs, biology, Cannabinoids, Illicit Drugs, business.industry, MDMA, General Medicine, biology.organism_classification, Psychiatry and Mental health, Neurology, Neurology (clinical), Cannabis, business, medicine.drug
Abstract: New psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which was not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly developed new substances and placed them on the market to replace the ones that have been banned; for this reason, during the last decade this class of substances has represented a great challenge for the public health and forensic toxicologists. The spectrum of side effects caused by the intake of these drugs of abuse is very wide since they act on different systems with various mechanisms of action. To date most studies have focused on the neurotoxic effects, very few works focus on cardiotoxicity. Specifically, both synthetic cannabinoids and synthetic cathinones appear to be involved in different cardiac events, including myocardial infarction and sudden cardiac death due to fatal arrhythmias. Synthetic cannabinoids and cathinones cardiotoxicity are mainly mediated through activation of the CB1 receptor present on cardiomyocyte and involved with reactive oxygen species production, ATP depletion and cell death. Concerns with the adrenergic over-stimulation induced by this class of substances and increasing oxidative stress are mainly reported. In this systematic review we aim to summarize the data from all the works analyzing the possible mechanisms through which synthetic cannabinoids and synthetic cathinones damage the myocardial tissue.
Published: 2021
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13. Successful weaning from mechanical ventilation after Serratus Anterior Plane block in a chest trauma patient

Author: Antonio Frangiosa, Manuela Sellini, Giovanni Marco Romano, Cristiano D’Errico, and Tullio Cafiero
Subjects: Mechanical ventilation, Trauma patient, business.industry, medicine.medical_treatment, Respiratory physiology, Pain management, Pulmonary function testing, Anesthesiology and Pain Medicine, Anesthesia, medicine, Weaning, Severe pain, In patient, Neurology (clinical), business
Abstract: Objectives Chest trauma is associated with severe pain, which can hamper normal breathing. Serratus Anterior Plane block (SAPB) is a novel technique, which provides analgesia for chest wall surgery. We describe an interesting clinical case about the use of SAPB to improve pain and pulmonary function in a patient with severe chest trauma. Case presentation We report the pain management and the clinical evolution of a patient in ICU, with a severe chest trauma, after performing the SAPB. Following the SAPB, the patient had a reduction in pain intensity and an improvement in both respiratory mechanics and blood gas analysis allowing a weaning from mechanical ventilator. Conclusions Pain control greatly affects mortality and morbidity in patients with chest trauma. SAPB seems to be safer and equally effective in pain control compared to epidural analgesia in patients with chest trauma.
Published: 2021
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14. Occupational physical activity, mortality and CHD events in the Italian Longitudinal Study

Author: Gabriella Sebastiani, Paola Di Filippo, Elena Strippoli, Amanda Hughes, and Angelo d’Errico
Subjects: Adult, Male, Longitudinal study, business.industry, Proportional hazards model, Public Health, Environmental and Occupational Health, Coronary Disease, Context (language use), Middle Aged, Mental health, Confidence interval, Occupational safety and health, Leisure Activities, Risk Factors, Risk of mortality, Humans, Medicine, Female, Longitudinal Studies, business, Exercise, Body mass index, Proportional Hazards Models, Demography
Abstract: Purpose Several recent studies have suggested a ‘physical activity paradox’ whereby leisure-time physical activity benefits health, but occupational physical activity is harmful. However, other studies imply that occupational physical activity is beneficial. Using data from a nationally representative Italian sample, we investigate if the context, or domain, of physical activity matters for mortality and coronary heart disease (CHD) events. Methods Among 40,220 men and women aged 40–55 at baseline, we used Cox models to compare associations of occupational, domestic and leisure-time physical activity with risk of mortality and CHD events over a follow-up period of up to 14 years. We accounted for sociodemographic factors, smoking, body mass index (BMI), physical and mental health, and educational qualifications. Results Occupational physical activity was not significantly associated with risk of mortality or CHD events for women, or with CHD events for men. In crude models, risk of mortality was higher for men in the highest occupational activity group, compared to the lowest (HR 1.26, 95% CI 1.01, 1.57). This attenuated with adjustment for health-related behaviours, health, and education (HR 1.03, 95% CI 0.77, 1.38). In crude models, leisure-time physical activity was significantly associated with decreased mortality and CHD risk only for men. Domestic physical activity was not associated with either outcome for either gender. Conclusion In a large sample of middle-aged Italian workers, we found limited evidence of harmful or beneficial effects of occupational physical activity on mortality or CHD events. However, confidence intervals were wide, and results consistent with a range of effects in both directions.
Published: 2021
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15. Low eGFR and albuminuria independently predict all-cause mortality in high-risk subjects undergoing coronary arteriography

Author: Mariateresa Santoliquido, Roberto Pontremoli, Pamela Piscitelli, Valentina Massa, Gianluigi Vendemiale, Carlo Vigna, Filippo Aucella, Maria Maddalena D’Errico, Salvatore De Cosmo, M P Salvatori, and Antonio Mirijello
Subjects: medicine.medical_specialty, education.field_of_study, business.industry, Urinary system, Confounding, Population, Renal function, medicine.disease, Gastroenterology, Coronary artery disease, Internal medicine, Emergency Medicine, Internal Medicine, Albuminuria, Medicine, Microalbuminuria, medicine.symptom, business, education, Kidney disease
Abstract: Individuals with Chronic Kidney Disease (CKD) are at high risk for cardiovascular morbidity and mortality. The aim of this study was to examine the relationship between renal dysfunction and all-cause mortality in a sample of subjects undergoing coronary angiography (CA). We evaluated 1017 subjects who consecutively underwent CA. Glomerular filtration rate (eGFR) was estimated by CKD-EPI and urinary albumin excretion reported as urinary albumin-to-creatinine ratio. Vital status was ascertained by interrogating the Italian Health Card Database. One-thousand-seventeen subjects (759 M/258F) were enrolled into the study from 2016 to 2018. One-hundred-fourteen deaths occurred during a median follow-up of 44 months. The whole population was divided in two subgroups according to the presence/absence of low eGFR (i.e.
Published: 2021
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16. High immature platelet fraction with reduced platelet count on hospital admission. Can it be useful for COVID‐19 diagnosis?

Author: Tiziana D’Errico, Emilio Assanelli, Alice Bonomi, Silvia S. Barbieri, Annalisa Cattaneo, Laura Salvini, Giovanni Introcaso, and Maria Luisa Biondi
Subjects: Male, Clinical Biochemistry, Pilot Projects, Immature Platelet, Diagnostic tools, Hemoglobins, COVID-19 Testing, Nasopharynx, Medicine, Aged, 80 and over, Covid‐19, Anemia, Cell Differentiation, Hematology, General Medicine, Middle Aged, Italy, Hospital admission, Disease Progression, H‐IPF, Female, Original Article, Emergency Service, Hospital, Mean Platelet Volume, Adult, Blood Platelets, hematological biomarkers, medicine.medical_specialty, emergency department, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), platelet parameters, Internal medicine, Humans, Pandemics, Aged, Cell Size, Retrospective Studies, Abnormal Platelet, Platelet Count, SARS-CoV-2, business.industry, Reduced platelet count, Biochemistry (medical), COVID-19, Original Articles, Emergency department, Blood Cell Count, business, Multiplex Polymerase Chain Reaction
Abstract: Introduction Health professions are heavily engaged facing the current threat of SARS‐CoV‐2 (COVID‐19). Although there are many diagnostic tools, an accurate and rapid laboratory procedure for diagnosing COVID‐19 is recommended. We focused on platelet parameters as the additional biomarkers for clinical diagnosis in patients presenting to the emergency department (ED). Materials and Methods Five hundred and sixty‐one patients from February to April 2020 have been recruited. Patients were divided into three groups: (N = 50) COVID‐19 positive and (N = 21) COVID‐19 negative with molecular testing, (N = 490) as reference population without molecular testing. A Multiplex rRT‐PCR from samples collected by nasopharyngeal swabs was performed and the hematological data collected. Results We detected a mild anemia in COVID‐19 group and lymphopenia against reference population: hemoglobin (g/dL) 13.0 (11.5‐14.8) versus 13.9 (12.8‐15.0) (P = .0135); lymphocytes (109/L) 1.24 (0.94‐1.73) versus 1.99 (1.49‐2.64) (P
Published: 2021
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17. Vaccines Against SARS-CoV-2 in Psoriasis Patients on Immunosuppressive Therapy: Implications of Vaccination Nationwide Campaign on Clinical Practice in Italy

Author: Annamaria Offidani, Giulio Rizzetto, Anna Campanati, Giulia Radi, Pamela Barbadoro, Federico Diotallevi, Marcello Mario D’Errico, and Emanuela Martina
Subjects: medicine.medical_specialty, Vaccines, Coronavirus disease 2019 (COVID-19), Pandemic, business.industry, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, Disease, Review, Dermatology, medicine.disease, Clinical Practice, Vaccination, Psoriasis, Family medicine, Agency (sociology), medicine, business
Abstract: More than 12 months have passed since the World Health Organization (WHO) declared Coronavirus Disease 19 (COVID-19), caused by the SARS-CoV2 virus, to be a pandemic on 11 March 2020. The entire world scientific community agrees that at this time vaccine is the most promising weapon to combat the infection and the severity of the disease. According to the document "Draft landscape of COVID-19 candidate vaccines" by WHO, 272 vaccines against SARS-CoV-2 virus are in development, although only four of these, produced by Pfizer-BioNTech (Pfizer, Inc. and BioNTech), Moderna, AstraZeneca, and Janssen companies, respectively, have been approved by European Medicines Agency and Italian Medicines Agency and subsequently distributed nationwide for use. These vaccines are the result of highly innovative procedures and are quite different from each other in terms of composition. Even clinicians in various medical fields may be unfamiliar with the effects of these vaccines. There is the strong emerging need for dermatologists to understand the crucial role of vaccines, with a focus on the need to vaccinate patients suffering from immune-mediated skin diseases, such as psoriasis, while taking the ongoing treatment into consideration regarding the timing of vaccination. Similarly, psoriasis patients aware of having an immune-mediated and inflammatory disease are increasingly asking the dermatologist information about the efficacy and safety of vaccines against SARS-CoV-2 virus. In this narrative review of the literature and critical analysis of the recommendations of the Italian Ministry of Health, we analyze the implications of the vaccination campaign on dermatological patients with psoriasis undergoing immunosuppressive treatment.
Published: 2021

18. Practice patterns regarding drains management in breast surgery: Results of a survey of Senonetwork Italia breast centers

Author: M. Trunfio, C. Cabula, F. Leone, S. Mancini, Dante Palli, Nicolò Scuderi, Corrado Rubino, Corrado Tinterri, F. D'Errico, A. Bafile, Francesca Rovera, Samuele Massarut, M. G. Lazzaretti, Manuela Roncella, C. Amanti, P. Zagarese, R. Giovanazzi, G. Lolli, Laura Biganzoli, D. Francesconi, Z. Arnez, Carlo Alberto Magni, M. Passamonti, Daniele Generali, M. Monti, F. Caruso, S. Burlizzi, S. Abonante, Annalisa Curcio, A. Massocco, A. Pellegrini, A. Huscher, Marina Bortul, Roberto Murgo, G. Pagani, Giovanni Tazzioli, G. Scalco, E. Cianchetti, Lucio Fortunato, M. Mirri, Andrea Sanguinetti, P. Frittelli, L. Manca, F. Ricci, F. Svegliati, P. Mainente, C. Caponi, Antonio Rulli, Diego Ribuffo, S. Folli, Fabio Corsi, C. Andreoli, P. Bravetti, F. Pellini, M. G. Pacquola, Lorenzo Menghini, Antonio Frassoldati, Daniele Friedman, P. Stefanini, L. Ambrosiani, C. Battaglia, A. Paduos, E. Manna, C. M. Ressa, M. Barbero, T. Pallara, F. Pietribiasi, O. Custodero, A. Bianchi, M. Saturno, Mario Taffurelli, C. Cedolini, G. Papaccio, C. Pagliari, B. Ballardini, E. M. Ruggeri, P. Persichetti, Massimo Grassi, Adele Sgarella, Vittorio Altomare, G. Mondini, Pallara, T., Fortunato, L., Folli, S., Roncella, M., Scuderi, N., Friedman, D., Arnez, Z., Ribuffo, D., Manna, E., Persichetti, P., Abonante, S, Altomare, V, Amanti, C, Ambrosiani, L, Andreoli, C, Bafile, A, Ballardini, B, Barbero, M, Battaglia, C, Bianchi, A, Biganzoli, L, Bortul, M, Bravetti, P, Burlizzi, S, Cabula, C, Caponi, C, Caruso, F, Cedolini, C, Cianchetti, E, Corsi, F, Curcio, A, Custodero, O, D'Errico, F, Francesconi, D, Frassoldati, A, Frittelli, P, Generali, D, Giovanazzi, R, Grassi, Mm, Huscher, A, Lazzaretti, Mg, Leone, F, Lolli, G, Magni, C, Mainente, P, Manca, L, Mancini, S, Massarut, S, Massocco, A, Menghini, L, Mirri, M, Mondini, G, Monti, M, Murgo, R, Pacquola, Mg, Paduos, A, Pagani, G, Pagliari, C, Palli, D, Papaccio, G, Passamonti, M, Pellegrini, A, Pellini, F, Pietribiasi, F, Ressa, Cm, Ricci, F, Rovera, F, Rubino, C, Ruggeri, Em, Rulli, A, Sanguinetti, A, Saturno, M, Scalco, G, Sgarella, A, Stefanini, P, Svegliati, F, Taffurelli, M, Tazzioli, G, Tinterri, C, Trunfio, M, Zagarese, P., Pallara T., Fortunato L., Folli S., Roncella M., Scuderi N., Friedman D., Arnez Z., Ribuffo D., Manna E., Persichetti P., Abonante S., Altomare V., Amanti C., Ambrosiani L., Andreoli C., Bafile A., Ballardini B., Barbero M., Battaglia C., Bianchi A., Biganzoli L., Bortul M., Bravetti P., Burlizzi S., Cabula C., Caponi C., Caruso F., Cedolini C., Cianchetti E., Corsi F., Curcio A., Custodero O., D'Errico F., Francesconi D., Frassoldati A., Frittelli P., Generali D., Giovanazzi R., Grassi M.M., Huscher A., Lazzaretti M.G., Leone F., Lolli G., Magni C., Mainente P., Manca L., Mancini S., Massarut S., Massocco A., Menghini L., Mirri M., Mondini G., Monti M., Murgo R., Pacquola M.G., Paduos A., Pagani G., Pagliari C., Palli D., Papaccio G., Passamonti M., Pellegrini A., Pellini F., Pietribiasi F., Ressa C.M., Ricci F., Rovera F., Rubino C., Ruggeri E.M., Rulli A., Sanguinetti A., Saturno M., Scalco G., Sgarella A., Stefanini P., Svegliati F., Taffurelli M., Tazzioli G., Tinterri C., Trunfio M., and Zagarese P.
Subjects: medicine.medical_specialty, Breast surgery, medicine.medical_treatment, MEDLINE, Breast Neoplasms, NO, Breast cancer, Internal Medicine, medicine, Humans, Breast, Practice Patterns, Physicians', Mastectomy, drains management, Practice patterns, business.industry, General surgery, breast surgery, Senonetwork Italia breast centers, medicine.disease, drains management, breast surgery, Senonetwork Italia breast centers, Oncology, Drainage, NA, Female, Surgery, business
Abstract: Surgery for breast cancer has changed in the last few decades in favor of more conservative approaches, without compromising loco‐regional control and survival. Common immediate complications fol ‐lowing breast surgery are hematoma, seroma, and wound infection.1Traditionally, surgeons have implemented the use of closed‐suction drains in this setting with the aim of preventing these complications, which can cause discomfort, morbidity, increased follow‐up visits,and possible delay in the beginning of adjuvant therapies.2 On the other hand, potential benefits of performing breast procedures without using a drain have been increasingly considered.3 There is lack of modern and official guidelines on use of drains in breast sur ‐gery, with no consensus regarding their management and the appro‐priate use of antibiotics in this setting. Almost all reports agree withthe use of drains after breast procedures, especially if they are asso‐ciated with reconstruction or axillar lymph node dissection (ALND), but an extreme variability is reported regarding practice patterns.4A national survey regarding the management of drains afterbreast cancer surgery was sent by email on January 2018 to all Breast Centers (BC) registered with Senonetwork Italia. Data col ‐lected by the administrative office of Senonetwork were de‐iden‐tified and exported for statistical analysis. A Steering Committeecomposed of general surgeons and plastic surgeons was appointedto coordinate the survey, which consisted of 22 multiple choicequestions, designed to inquire about surgeons' demographics, use of drains after breast procedures with and without reconstructionand/or ALND, antibiotic use and to characterize drain managementin their clinical practice.
Published: 2020
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19. The conductor’s intensity gestures

Author: Isabella Poggi, Francesca D'Errico, Alessandro Ansani, Poggi, Isabella, D’Errico, Francesca, and Ansani, Alessandro
Subjects: Communication, business.industry, Repertoire, 05 social sciences, Perspective (graphical), conducting, gesture, music performance, intensity, dynamic indication, iconic gestures, symbolic gestures, conducting, gesture, music performance, intensity, dynamic indication, iconic gestures, symbolic gestures, 06 humanities and the arts, 050105 experimental psychology, 060404 music, Conductor, Choir, 0501 psychology and cognitive sciences, Psychology (miscellaneous), business, Psychology, 0604 arts, Music, Gesture
Abstract: This work is aimed at outlining a repertoire of conductors’ gestures. In this perspective, it presents two studies that investigate a specific subset of the body signals of orchestra and choir conductors, namely, the gestures for musical intensity. First, an observational qualitative study, based on a systematic coding of a corpus of fragments from orchestra concerts and rehearsals, singled out 21 gestures, in which either the gesture as a whole or some aspects of it conveyed indications for forte, piano, crescendo, or diminuendo; some are symbolic gestures, used either with the same meaning as in everyday interaction or with one specific of conductors; others are iconic gestures, both directly or indirectly iconic. Second, in a perception study, a questionnaire submitted to 77 participants tested if 8 gestures of intensity out of the 21 singled out by the coding study are in fact shared and understood, and whether they are better interpreted by music experts than by laypeople. Results showed that the tested gestures are fairly comprehensible, not only by experts but also by non-expert participants, probably due, for some gestures, to their high level of iconicity, and for others to their closeness to everyday gestures.
Published: 2020
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20. Barriers and Recommendations Associated With Human Papillomavirus Vaccination Among College Students

Author: Rhone D’Errico, Wei-Chen Tung, Maria Poggio D’Errico, and Minggen Lu
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, College health, education.field_of_study, business.industry, Nurse practitioners, Health care provider, Population, 030204 cardiovascular system & hematology, Human papillomavirus vaccination, Vaccination, 03 medical and health sciences, 0302 clinical medicine, Family medicine, medicine, Residence, 030212 general & internal medicine, Human papillomavirus, business, education
Abstract: Many college students are unimmunized against the human papillomavirus (HPV), and college health nurse practitioners (NPs) are in a unique position to provide catch-up vaccination. This is an NP-led quantitative study using a cross-sectional and descriptive survey design to assess perceived HPV vaccine barriers and effective vaccine recommendations among 627 United States college students. The most commonly reported barrier was the lack of a health care provider’s recommendation followed by not knowing where to obtain the vaccine and a lack of self-perceived risks. The majority reported a health care provider’s recommendation as most effective in encouraging them to obtain the vaccine. Males were less likely to be concerned with side effects but more likely to not know where to obtain the vaccine. Participants with a shorter length of residence in the US preferred vaccine recommendations from parents. White participants were more likely to prefer a recommendation from a health care provider compared with Hispanics. The study results inform NP practice by highlighting the unique barriers to HPV immunization in the college population and guiding NPs in making effective vaccine recommendations to college students.
Published: 2020
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21. Combined surgical and negative pressure therapy to treat multiple enterocutaneous fistulas and abdominal abscesses: A case report

Author: Gaetano Luglio, Giovanni Domenico De Palma, Enrica Esposito, Gianluca Pagano, Francesca Paola Tropeano, Alfonso Amendola, Giuseppe De Simone, Paola Dinuzzi, Chiara Errico, Giuseppe Palomba, Luglio, G., Amendola, A., Pagano, G., Tropeano, F. P., Errico, C., Esposito, E., Palomba, G., Dinuzzi, P., De Simone, G., and De Palma, G. D.
Subjects: medicine.medical_specialty, Fistula, Enterocutaneous fistulas, abdominal wall closure, Case Report, Negative pressure therapy, Abdominal wall, 03 medical and health sciences, Abdominal wall closure, 0302 clinical medicine, Enterocutaneous fistula, VAC therapy, Medicine, Abscess, business.industry, Abdominal Abscess, General Medicine, medicine.disease, Surgery, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Concomitant, 030211 gastroenterology & hepatology, Presentation (obstetrics), Pouch, business
Abstract: Introduction We report the case of a successful management with combined aggressive surgery and negative pressure therapy, to treat a severely ill-septic patient, affected by multiple chronic enterocutaneous fistulas. Presentation of case A 26-year-old female patient presented with multiple pelvic and intra-abdominal abscesses, enterocutaneous fistulas and central venous catheter-related bacteraemia in extremely poor general conditions. The patient underwent both an abdominal CT which showed multiple digestive loops stuck and apparently fistulised and an abdominal-pelvic MRI, confirming the CT findings, and demonstrating a third fistula involving the Pouch and responsible for a pelvic and retroperitoneal chronic abscess. Given the patient's septic condition, despite several attempts of conservative therapies, an aggressive surgical approach was adopted. After temporary abdominal wall closure, the patient underwent Vacuum Assisted Closure therapy in order to close the abdominal wall and drain the residual abscess. The patient was discharged at the 35th post-operative day in good general conditions. Discussion This case is about a complex, long-lasting clinical scenario, progressively leading a young woman to death despite several attempts of conservative therapy, sometimes allowed to treat enterocutaneous fistulas. The use of negative pressure therapy to manage open abdomen is still controversial. Patients affected by enterocutaneous fistulas are in need of adequate nutritional support due to their hypercatabolic state, secondary both to the fluid loss and the concomitant inflammatory status. Conclusion When conservative management fails and the patient shows septic complications, a multidisciplinary aggressive approach, including surgery, negative-pressure therapy and hyperbaric oxygen therapy is required to treat this life-threatening condition., Highlights • Using negative pressure therapy to deal with difficult abdominal wall closure. • Multidisciplinary team work is essential to optimize patients' surgical outcomes. • Highly-demolitive surgery can benefit from the use of negative pressure therapy.
Published: 2020

22. Autonomous reconfiguration of a distributed synthetic aperture radar driven by mission requirements

Author: S. Sarno, Marco D'Errico, Jian Guo, Eberhard Gill, Sarno, S, D'Errico, M, Guo, J, and Gill, E
Subjects: Formation flying, Synthetic aperture radar, Spacecraft, Computer science, business.industry, Distributed SAR, Real-time computing, Aerospace Engineering, Control reconfiguration, ComputerApplications_COMPUTERSINOTHERSYSTEMS, 01 natural sciences, 010305 fluids & plasmas, Autonomous reconfiguration, 010309 optics, Space and Planetary Science, Physics::Space Physics, 0103 physical sciences, Orbit (dynamics), Trajectory, Relative guidance, Satellite, Motion planning, State (computer science), business, Path planning
Abstract: This paper introduces a strategy for an autonomous reconfiguration of a fractionated synthetic aperture radar (SAR) spacecraft system. The radar antenna is distributed on a small-satellite formation that can be reconfigured on orbit depending on the mission requirements. Once the acquisition geometry is specified in terms of formation type and the desired requirements are defined, the information is transmitted to the cluster. Hence, each satellite determines its own final state and elaborates the necessary trajectory for maneuvering. The reconfiguration algorithm is decentralized and exists in a distributed computational architecture. Therefore, the spacecraft platforms are assumed to be equal and able to communicate among each other. To demonstrate the viability of the proposed approach, a specific scenario is considered, with a distributed SAR operating at X-band that has to be reconfigured for interferometric applications. Simulation results show that once remote sensing requirements are specified, the developed algorithm can manage autonomously the spacecraft reconfiguration toward the corresponding operative pattern.
Published: 2020
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23. The histological assessment of liver fibrosis in grafts from extended criteria donors predicts the outcome after liver transplantation: A retrospective study

Author: Mattia Riefolo, Giacomo Santandrea, Carlo de Cillia, Matteo Cescon, Melissa Monica, Antonia D'Errico, Francesco Vasuri, Vanessa De Pace, Matteo Ravaioli, Matteo Serenari, D'Errico A., Riefolo M., Serenari M., De Pace V., Santandrea G., Monica M., de Cillia C., Ravaioli M., Cescon M., and Vasuri F.
Subjects: Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Histopathology, Context (language use), Dyslipidemic donor, Liver transplantation, Gastroenterology, Donor Selection, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Fibrosis, Cause of Death, Internal medicine, Biopsy, medicine, Humans, Early allograft dysfunction, Portal fibrosis, Aged, Dyslipidemias, Retrospective Studies, Hepatology, medicine.diagnostic_test, business.industry, Incidence, Graft Survival, Middle Aged, medicine.disease, Survival Analysis, Liver Transplantation, Treatment Outcome, surgical procedures, operative, Italy, 030220 oncology & carcinogenesis, Liver biopsy, Female, 030211 gastroenterology & hepatology, business, Dyslipidemia
Abstract: Background The use of extended criteria donors (ECD) in liver transplantation is increasing due to the organ shortage. Histological evaluation of the liver graft in the context of procurement is an important tool for extending the donor pool without affecting the quality of the transplanted organs. Macrovesicular steatosis is widely accepted as predictor of early allograft dysfunction (EAD), while other features, such as portal fibrosis, are poorly studied. Aim To identify morphological features, other than macrovesicular steatosis, that may affect recipients’ outcome. Methods Between 2014 and 2016, 132 donors with extended criteria underwent pre-transplant liver biopsy during procurement. Histological variables of the graft, donors’/recipients’ clinical data, EAD and patient/graft survival were registered. Results The recipients who received a graft with histological-proven portal fibrosis had a significant lower patient and graft survival in comparison to patients without fibrosis (P = 0.044 and P = 0.039, respectively). Donors’ dyslipidemia was significantly associated with the occurrence of EAD (P = 0.021). When dyslipidemia was combined with histological liver fibrosis a 54.5% incidence of EAD was observed (P = 0.012). Conclusions The histological assessment of liver fibrosis in pre-transplant biopsy of ECD grafts, together with donor’s clinical data, provides important information on recipients’ outcome.
Published: 2020
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24. Feasibility Study on the Redesign of a Metallic Car Hood by Using Composite Materials

Author: Giustino Magno, Gianluca Monsurrò, Giuseppe D’Errico, Alessandro Cozzolino, Andrea Sellitto, Aniello Riccio, Sellitto, A., Riccio, A., Magno, G., D'Errico, G., Monsurro, G., and Cozzolino, A.
Subjects: Optimization, Injury control, Computer science, business.industry, 020209 energy, Automotive industry, Stiffness, Minimum weight, Poison control, 02 engineering and technology, Composite laminates, Hood, 020303 mechanical engineering & transports, Safeguard, Sandwich structure, 0203 mechanical engineering, Automotive Engineering, 0202 electrical engineering, electronic engineering, information engineering, medicine, Fuel efficiency, Composite laminate, medicine.symptom, Composite material, business, HIC
Abstract: Nowadays, fuel consumption and exhaust emissions are topical issues in the automotive field, as environmental safeguard legislation constraints are going to get tougher. Indeed, one of the most efficient methods to contain fuel consumption and emissions is the weight reduction of the vehicle. In this paper, a feasibility study on the lightweight redesign of a metallic car hood by using composite materials is presented. In particular, two different configurations, employing composite laminates and sandwich structures, are investigated. The feasibility of each configuration is assessed in terms of stiffness specifications and pedestrian safety requirement. Hence, Head Injury Criteria are employed, according to regulations. Finally, an optimization procedure on the stacking sequence of the composite laminates is performed, to determine, among the feasible solutions, the one characterized by the minimum weight.
Published: 2020
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25. Intrahepatocellular crystal storing mimicking a clinical liver disease during monoclonal gammopathy: report of a case and review of the literature

Author: Mattia Riefolo, Francesco Vasuri, Clara Bertuzzi, Deborah Malvi, Sabrina Valente, Gianandrea Pasquinelli, Elena Sabattini, Antonia D'Errico, Riefolo M., Malvi D., Bertuzzi C., Sabattini E., Valente S., Pasquinelli G., D'Errico A., and Vasuri F.
Subjects: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Crystal-storing histiocytosi, Paraproteinemias, Pathology and Forensic Medicine, Diagnosis, Differential, Crystal storing histiocytosis, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Structural Biology, transmission electron microscopy, medicine, Humans, Aged, Inclusion Bodies, Unusual case, business.industry, Liver Diseases, monoclonal gammopathy, immunogold labeling, Immunogold labelling, medicine.disease, Lysosomal Storage Diseases, Histiocytosis, Monoclonal gammopathy, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, histopathology, Immunoglobulin Light Chains, Histopathology, Bone marrow, medicine.symptom, liver disease, business
Abstract: We present an unusual case of liver involvement in monoclonal gammopathy with generalized crystal-storing histiocytosis (G-CSH). A bone marrow storage disease was diagnosed in a 79-year-old man with monoclonal gammopathy of uncertain significance (MGUS). The patient presented with pleural effusion, an osteolytic lesion of the humerus, and an increase of aspartate transaminase and cholestatic markers that raised the clinical suspect of liver disease. A second bone marrow biopsy confirmed the diagnosis of MGUS with a histiocytic component suggestive for G-CSH. Liver biopsy showed an unremarkable histology, no significant inflammatory infiltrates, and intrasinusoidal foamy histiocytes. PAS and Masson’s trichrome stains, showed, in the cytoplasm of both histiocytes and hepatocytes, rod-shaped eosinophilic crystals, which were immunoreactive for kappa light chains. Transmission electron microscopy performed on reprocessed histological sections confirmed the presence of crystals in the hepatocyte cytoplasms. Immunogold labeling intensely stained crystals for kappa light chains. To the best of our knowledge, this is the second case in which an intrahepatocellular crystal storage is described during liver involvement in G-CSH. The present case also suggests that an increase in liver serum enzymes may support the clinical diagnosis of liver CSH in a patient with MGUS.
Published: 2020
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26. The Relationship between Timing of Pretransplant Kidney Biopsy, Graft Loss, and Survival in Kidney Transplantation:An Italian Cohort Study

Author: Francesco Vasuri, Massimo Del Gaudio, Matteo Ravaioli, Maurizio Sessa, Matteo Serenari, Deborah Malvi, Olga Baraldi, Gaetano La Manna, Giuliana Germinario, Vania Cuna, Irene Capelli, Federica Odaldi, Giorgia Comai, Raffaele Bova, Giacomo Frascaroli, Lorenzo Maroni, Antonietta D'Errico, Valentina Rosa Bertuzzo, Gabriela Sangiorgi, Chiara Zanfi, Odaldi F., Serenari M., Comai G., La Manna G., Bova R., Frascaroli G., Malvi D., Maroni L., Vasuri F., Germinario G., Baraldi O., Capelli I., Cuna V., Sangiorgi G., D'Errico A., Del Gaudio M., Bertuzzo V.R., Zanfi C., Sessa M., and Ravaioli M.
Subjects: Graft Rejection, Male, medicine.medical_specialty, Biopsy, Urology, Kidney biopsy, Kidney, Cold Ischemia Time, Cohort Studies, Solid tumors, Medicine, Humans, Kidney clinical, Kidney transplantation, Aged, Outcome, Aged, 80 and over, medicine.diagnostic_test, business.industry, Graft Survival, Graft survival, Middle Aged, medicine.disease, Kidney Transplantation, Confidence interval, Tissue Donors, Transplantation, Survival Rate, medicine.anatomical_structure, Italy, Propensity score matching, Preoperative Period, Female, business, Cohort study
Abstract: Introduction: Kidney biopsy is performed to assess if an extended criteria graft can be used for transplantation. It may be performed before or after cross-clamping during organ procurement. This study aims to evaluate whether the timing of biopsy may modify cold ischemia times (CIT) and/or graft outcomes. Methods: Kidney transplants performed in our center from January 2007 to December 2017 were analyzed. Grafts with preimplantation kidney biopsy were included. Biopsies were performed during surgical back table (ex situ kidney biopsy [ESKB]) until 2012 and since then before the aortic cross-clamping (in situ kidney biopsy [ISKB]). To overcome biases owing to different distributions, a propensity score model was developed. The study population consists in 322 patients, 115 ESKB, and 207 ISKB. Results: CIT was significantly lower for ISKB (730 min ISKB vs. 840 min ESKB, p value = 0.001). In both crude (OR 0.27; 95% confidence interval, 95% CI 0.12–0.60; p value = 0.002) and adjusted analyses (OR 0.37; 95% CI 0.14–0.94; p value = 0.039), ISKB was associated with a reduced odd of graft loss when compared to ESKB. Discussion/Conclusion: Performing preimplantation kidney biopsy during the recovery, prior to the aortic cross-clamping, may be a strategy to reduce CIT and improve transplant outcomes.
Published: 2022
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27. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author: Giorgio Bogani, Giovanni Scambia, Chiara Cimmino, Francesco Fanfani, Barbara Costantini, Matteo Loverro, Gabriella Ferrandina, Fabio Landoni, Luca Bazzurini, Tommaso Grassi, Domenico Vitobello, Gabriele Siesto, Anna Myriam Perrone, Vanna Zanagnolo, Pierandrea De Iaco, Francesco Multinu, Fabio Ghezzi, Jvan Casarin, Roberto Berretta, Vito A Capozzi, Errico Zupi, Gabriele Centini, Antonio Pellegrino, Silvia Corso, Guido Stevenazzi, Serena Montoli, Anna Chiara Boschi, Giuseppe Comerci, Pantaleo Greco, Ruby Martinello, Francesco Sopracordevole, Giorgio Giorda, Tommaso Simoncini, Marta Caretto, Enrico Sartori, Federico Ferrari, Antonio Cianci, Giuseppe Sarpietro, Maria Grazia Matarazzo, Fulvio Zullo, Giuseppe Bifulco, Michele Morelli, Annamaria Ferrero, Nicoletta Biglia, Fabio Barra, Simone Ferrero, Umberto Leone Roberti Maggiore, Stefano Cianci, Vito Chiantera, Alfredo Ercoli, Giulio Sozzi, Angela Martoccia, Sergio Schettini, Teresa Orlando, Francesco G Cannone, Giuseppe Ettore, Andrea Puppo, Martina Borghese, Canio Martinelli, Ludovico Muzii, Violante Di Donato, Lorenza Driul, Stefano Restaino, Alice Bergamini, Giorgio Candotti, Luca Bocciolone, Francesco Plotti, Roberto Angioli, Giulia Mantovani, Marcello Ceccaroni, Chiara Cassani, Mattia Dominoni, Laura Giambanco, Silvia Amodeo, Livio Leo, Raphael Thomasset, Diego Raimondo, Renato Seracchioli, Mario Malzoni, Franco Gorlero, Martina Di Luca, Enrico Busato, Sami Kilzie, Andrea Dell'Acqua, Giovanna Scarfone, Paolo Vercellini, Marco Petrillo, Salvatore Dessole, Giampiero Capobianco, Andrea Ciavattini, Giovanni Delli Carpini, Luca Giannella, Liliana Mereu, Saverio Tateo, Flavia Sorbi, Massimiliano Fambrini, Stefania Cicogna, Federico Romano, Giuseppe Ricci, Giuseppe Trojano, Roberto Consonni, Simona Cantaluppi, Antonio Lippolis, Raffaele Tinelli, Giovanni D'Ippolito, Lorenzo Aguzzoli, Vincenzo D Mandato, Stefano Palomba, Davide Calandra, Maurizio Rosati, Cinzia Gallo, Daniela Surico, Valentino Remorgida, Francesco Ruscitto, Paolo Beretta, Pierluigi Benedetti Panici, Francesco Raspagliesi, Bogani G., Scambia G., Cimmino C., Fanfani F., Costantini B., Loverro M., Ferrandina G., Landoni F., Bazzurini L., Grassi T., Vitobello D., Siesto G., Perrone A.M., Zanagnolo V., De Iaco P., Multinu F., Ghezzi F., Casarin J., Berretta R., Capozzi V.A., Zupi E., Centini G., Pellegrino A., Corso S., Stevenazzi G., Montoli S., Boschi A.C., Comerci G., Greco P., Martinello R., Sopracordevole F., Giorda G., Simoncini T., Caretto M., Sartori E., Ferrari F., Cianci A., Sarpietro G., Matarazzo M.G., Zullo F., Bifulco G., Morelli M., Ferrero A., Biglia N., Barra F., Ferrero S., Maggiore U.L.R., Cianci S., Chiantera V., Ercoli A., Sozzi G., Martoccia A., Schettini S., Orlando T., Cannone F.G., Ettore G., Puppo A., Borghese M., Martinelli C., Muzii L., Di Donato V., Driul L., Restaino S., Bergamini A., Candotti G., Bocciolone L., Plotti F., Angioli R., Mantovani G., Ceccaroni M., Cassani C., Dominoni M., Giambanco L., Amodeo S., Leo L., Thomasset R., Raimondo D., Seracchioli R., Malzoni M., Gorlero F., Di Luca M., Busato E., Kilzie S., Dell'acqua A., Scarfone G., Vercellini P., Petrillo M., Dessole S., Capobianco G., Ciavattini A., Delli Carpini G., Giannella L., Mereu L., Tateo S., Sorbi F., Fambrini M., Cicogna S., Romano F., Ricci G., Trojano G., Consonni R., Cantaluppi S., Lippolis A., Tinelli R., D'ippolito G., Aguzzoli L., Mandato V.D., Palomba S., Calandra D., Rosati M., Gallo C., Surico D., Remorgida V., Ruscitto F., Beretta P., Panici P.B., Raspagliesi F., Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, Raspagliesi, Francesco, Bogani, G., Scambia, G., Cimmino, C., Fanfani, F., Costantini, B., Loverro, M., Ferrandina, G., Landoni, F., Bazzurini, L., Grassi, T., Vitobello, D., Siesto, G., Perrone, A. M., Zanagnolo, V., De Iaco, P., Multinu, F., Ghezzi, F., Casarin, J., Berretta, R., Capozzi, V. A., Zupi, E., Centini, G., Pellegrino, A., Corso, S., Stevenazzi, G., Montoli, S., Boschi, A. C., Comerci, G., Greco, P., Martinello, R., Sopracordevole, F., Giorda, G., Simoncini, T., Caretto, M., Sartori, E., Ferrari, F., Cianci, A., Sarpietro, G., Matarazzo, M. G., Zullo, F., Bifulco, G., Morelli, M., Ferrero, A., Biglia, N., Barra, F., Ferrero, S., Leone Roberti Maggiore, U., Cianci, S., Chiantera, V., Ercoli, A., Sozzi, G., Martoccia, A., Schettini, S., Orlando, T., Cannone, F. G., Ettore, G., Puppo, A., Borghese, M., Martinelli, C., Muzii, L., Di Donato, V., Driul, L., Restaino, S., Bergamini, A., Candotti, G., Bocciolone, L., Plotti, F., Angioli, R., Mantovani, G., Ceccaroni, M., Cassani, C., Dominoni, M., Giambanco, L., Amodeo, S., Leo, L., Thomasset, R., Raimondo, D., Seracchioli, R., Malzoni, M., Gorlero, F., Di Luca, M., Busato, E., Kilzie, S., Dell'Acqua, A., Scarfone, G., Vercellini, P., Petrillo, M., Dessole, S., Capobianco, G., Ciavattini, A., Delli Carpini, G., Giannella, L., Mereu, L., Tateo, S., Sorbi, F., Fambrini, M., Cicogna, S., Romano, F., Ricci, G., Trojano, G., Consonni, R., Cantaluppi, S., Lippolis, A., Tinelli, R., D'Ippolito, G., Aguzzoli, L., Mandato, V. D., Palomba, S., Calandra, D., Rosati, M., Gallo, C., Surico, D., Remorgida, V., Ruscitto, F., Beretta, P., Benedetti Panici, P., Raspagliesi, F., Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Maggiore, U. L. R., and Panici, P. B.
Subjects: medicine.medical_specialty, endometrial neoplasms, Coronavirus disease 2019 (COVID-19), Endometrial Cancer, COVID-19, Uterine cancer, SARS-CoV-2, covid-19, endometrial cancer, sars-cov-2, uterine cancer, female, humans, pandemics, retrospective studies, NO, Retrospective Studie, Pandemic, medicine, Patterns of care, Obstetrics, business.industry, Endometrial cancer, Obstetrics and Gynecology, General Medicine, medicine.disease, Endometrial Neoplasms, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, Original Article, Female, business, Human
Abstract: Objective Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p, Synopsis The prevalence of patients with early-stage endometrial cancer (EC) has been lower during coronavirus disease 2019 (COVID-19) pandemic than before its onset. Further evidence is needed to assess the impact of COVID-19 pandemic on survival outcomes of EC patients.
Published: 2022

28. Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α

Author: Paola Frati, Massimo Martelloni, Letizia Alfieri, Roberto Scendoni, Maurizio Lestani, Stefano D'Errico, Carlo Moreschi, Diana Bonuccelli, Paolo Frisoni, Martina Zanon, Vittorio Fineschi, Alessandro Santurro, Margherita Neri, Rosa Maria Gaudio, Ombretta Turriziani, Mariano Cingolani, Marco Di Paolo, Matteo Marti, and Matteo Scopetti
Subjects: ARDS, Pathology, medicine.medical_specialty, Interleukin-1beta, RT-PCR, Autopsy, COVID-19 related-death, Cytokines, Immunohistochemistry, Pneumonia, RT-PCR, SARS-CoV-2, NO, Pathology and Forensic Medicine, Proinflammatory cytokine, Settore MED/43 - Medicina Legale, Humans, Medicine, Respiratory system, Interleukin 6, Interleukin-15, Lung, biology, Interleukin-6, Tumor Necrosis Factor-alpha, SARS-CoV-2, business.industry, COVID-19, Endothelial Cells, Correction, Pneumonia, General Medicine, Viral Load, Autopsy, COVID-19 related-death, Cytokines, Immunohistochemistry, medicine.disease, medicine.anatomical_structure, Interleukin 15, biology.protein, Original Article, Cytokine Release Syndrome, business, Cytokine storm
Abstract: This study involves the histological analysis of samples taken during autopsies in cases of COVID-19 related death to evaluate the inflammatory cytokine response and the tissue localization of the virus in various organs. In all the selected cases, SARS-CoV-2 RT-PCR on swabs collected from the upper (nasopharynx and oropharynx) and/or the lower respiratory (trachea and primary bronchi) tracts were positive. Tissue localization of SARS-CoV-2 was detected using antibodies against the nucleoprotein and the spike protein. Overall, we tested the hypothesis that the overexpression of proinflammatory cytokines plays an important role in the development of COVID-19-associated pneumonia by estimating the expression of multiple cytokines (IL-1β, IL-6, IL-10, IL-15, TNF-α, and MCP-1), inflammatory cells (CD4, CD8, CD20, and CD45), and fibrinogen. Immunohistochemical staining showed that endothelial cells expressed IL-1β in lung samples obtained from the COVID-19 group (p
Published: 2021
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29. Numerical and experimental investigations of the early injection process of Spray G in a constant volume chamber and an optically accessible DISI engine

Author: Gianluca D'Errico, Cooper Welch, Marius Schmidt, Christopher Geschwindner, Tommaso Lucchini, Christian Hasse, Andrea Pati, Benjamin Böhm, and Davide Paredi
Subjects: Spray G, Materials science, ECN, business.industry, Mechanical Engineering, Breakup model, Process (computing), Aerospace Engineering, Mechanical engineering, Darmstadt optical engine, Ocean Engineering, Injector, Computational fluid dynamics, Combustion, law.invention, Physics::Fluid Dynamics, Volume (thermodynamics), law, DISI, multi-hole injector, Automotive Engineering, Spark (mathematics), CFD, business
Abstract: In this work, the Engine Combustion Network Spray G injector was mounted in the Darmstadt optical-accessible engine to study phenomena typical of multi-hole, early direct-injection events in spark-ignition engines characterized by tumble flow charge motion. Dedicated experimental measurements of both in-cylinder spray morphology and flow velocities before and after the injection process were carried out to assess the adopted numerical setup under real engine conditions. A dynamic secondary breakup model from the literature was coupled with an atomization multi-motion regime model. The model was validated against state-of-the-art ECN Spray G experiments for a constant-volume chamber under low evaporating condition. Then, the simulation of the spray injection in the engine was carried out and the achieved results were compared against the experimental data. Overall, good agreement between experiments and simulations was observed for the spray morphology and velocity fields in both cases. With reference to engine calculations the intake flow was seen to induce spray asymmetry. A partial vortex generated during the intake phase on the tumble plane interacts with the spray, developing into a full vortex which induces an upward flow that stabilizes the spray. The upward flows below the intake valve increase the dilution of the plume outside the tumble plane, which therefore exhibits reduced penetration. Moreover, the intake valves protect from the energetic intake flow the recirculation vortex generated at the tip of the plumes that lie outside the tumble plane. The intake flow helps fuse the vapor fuel clouds of the individual plumes near the injector tip, obtaining a vapor fuel with a shape like that generated by a horseshoe multi-hole injector. Finally, a phenomenological model of the interaction between the multi-hole injector jets and the engine intake flow was introduced to describe the spray evolution in a typical DISI engine.
Published: 2021
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30. Influence of sample preparation optimization on the accuracy of dose assessment of an automatic non-fluorescent MN scoring system

Author: Francesco D'Errico, Géza Sáfrány, Csilla Pesznyák, Zsuzsa S Kocsis, Tímea Hülber, Eniko Kis, and Judit Németh
Subjects: sample preparation optimization, Scoring system, biodosimetry, medicine.medical_treatment, Brachytherapy, Image processing, Automatic micronucleus assay (MN), Quality (physics), Image Processing, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Sample preparation, Lymphocytes, Cytokinesis, Mathematics, Protocol (science), Detection limit, Micronucleus Tests, Radiological and Ultrasound Technology, business.industry, quantified slide quality, Homogeneity (statistics), Pattern recognition, Artificial intelligence, business, Algorithms, Software
Abstract: PURPOSE Automatizing the scoring of the cytokinesis-blocked micronucleus assay spares a lot of valuable time. The dose-effect relationship can be applied reliably for dose estimation if the quality of the slides is the same from the perspective of the used image processing algorithm. This aspect brings in additional requirements against the quality of the slides compared to the conventional visual scoring. MATERIALS AND METHODS An add-in software was created to the non-fluorescent RS-MN automatic MN scoring system which is capable of measuring quantitatively the degree of typical anomalies. The image processing is less reliable when the presence of these anomalies is more frequent. The behavior of the designed sample quality parameters (SQPs) was tested on in vitro irradiated peripheral blood samples (0, 1, and 2 Gy) obtained from a healthy donor and also on samples from patients undergoing low dose-rate brachytherapy. RESULTS We examined 20 different SQPs and identified two that are independent and correlate significantly with the error of the fully automatic MN frequency. One is related to the size of the cells and the other reflects the homogeneity of the environment. An equation was established which presents a connection between the error of the auto MN frequency and the SQPs. By adding a fourth cleaning step to the conventional sample preparation and changing the pre-dripping temperature of the slide, the SQP can be modified, and consequently, the sample quality can be improved. The gain in accuracy is 54 ± 10 MN per 1000 binucleated cells, which corresponds to the effects of 0.5 Gy. Around the lowest limit of detection (
Published: 2021
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31. Drug-induced colitis on BRAF and MEK inhibitors for BRAF V600E-mutated non-small cell lung cancer: a case report

Author: Alessandro Federico, Maria Lucia Tardio, Andrea Ardizzoni, Stefania Salvagni, Francesco Gelsomino, Antonietta D'Errico, and Giada Grilli
Subjects: MAPK/ERK pathway, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Lung Neoplasms, Perforation (oil well), Short Report, Colonoscopy, Antineoplastic Agents, Gastroenterology, BRAF, chemistry.chemical_compound, Non-small cell lung cancer, Internal medicine, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), Colitis, Adverse effect, Lung cancer, Aged, Pharmacology, Mitogen-Activated Protein Kinase Kinases, Sulfonamides, medicine.diagnostic_test, business.industry, Gastrointestinal toxicity, Binimetinib, medicine.disease, MEK, Oncology, chemistry, Mutation, Vomiting, Benzimidazoles, Carbamates, medicine.symptom, business
Abstract: Summary Introduction. The combination of BRAF and MEK inhibitors has deeply changed the treatment of BRAF V600-mutant non-small cell lung cancer patients. These agents demonstrated high antitumor activity as well as safe and manageable toxicity profile. Hypertension, pyrexia and increased liver enzymes are the most common adverse events. Gastrointestinal toxicities are rare, and mainly consist of mild grade vomiting and diarrhea. Case report. We report the case of 70-year-old man affected by BRAF V600-mutant NSCLC with bilateral lung and bone metastases. First-line treatment with encorafenib (450 mg once daily) and binimetinib (45 mg twice daily) was administered within a clinical trial. At the first radiological assessment, computed tomography (CT) scan showed a partial response and signs of intestinal inflammation were reported. The investigational treatment was timely withheld. The subsequent colonoscopy demonstrated the presence of ulcerative lesions at the caecal tract, and the histological diagnosis suggested a drug-induced colitis. No specific treatment was given as the patient did not report abdominal disturbances. Forty-five days after treatment interruption a new CT scan showed the resolution of bowel inflammation and investigational treatment was resumed at the same doses. The patient is still alive and free of toxicity recurrence after 11 months from treatment initiation. Conclusion. Severe gastrointestinal toxicities are uncommon with BRAF and MEK inhibitors, although cases of colitis and intestinal perforation have already been reported in literature. The pathogenesis seems to be related to the MAPK pathway inhibition performed by MEK inhibitors. These adverse events should be accounted given the potential to evolve into life-threatening conditions.
Published: 2021

32. Giant intracranial infantile myofibromatosis of the skull base: report of two cases

Author: Delfina Bifano, Gloria Tresserras-Giné, Lucia Quaglietta, Lucia De Martino, Giuseppe Cinalli, Mariaelena Errico, and Pietro Spennato
Subjects: Nasal cavity, medicine.medical_specialty, Infantile myofibromatosis, Prenatal diagnosis, medicine, Humans, Child, Skull Base, business.industry, Infant, Soft tissue, Myofibromatosis, General Medicine, medicine.disease, Trunk, Skull, medicine.anatomical_structure, Anterior cranial fossa, Child, Preschool, Pediatrics, Perinatology and Child Health, Neurology (clinical), Neurosurgery, Radiology, Nasal Cavity, business, Head
Abstract: Infantile myofibromatosis is a rare and nonmalignant pediatric tumor of myofibroblastic origin that may occur in solitary or multifocal forms. Soft tissue of the head and neck, trunk, and extremities, skeleton, and viscera are usually involved. Intracranial involvement is reported to be extremely rare, and its clinical picture has been poorly characterized. We present two cases of giant infantile myofibromatosis of the skull base with intracranial involvement. The first case with prenatal diagnosis involved extensively the extradural space of the occipital region and was previously treated by chemotherapy for a previous diagnosis of hemangioperycitoma. Tumor was removed at the age of 5 months and no recurrence was observed during the 3-year follow-up. The second case in a 2-year-old baby involved the anterior cranial base, the nasal cavity, the right orbit, and presented massive involvement of the anterior cranial fossa. Surgery allowed complete removal and a recurrence-free period of 7 years after surgery. Treatment options for these unusual cases are presented and details of histological diagnosis are discussed.
Published: 2021
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33. ePortfolio in Teacher Education and Academic Further Education

Author: Barbara D'Errico and Christine Ziegelbauer
Subjects: Further education, Higher education, business.industry, Lifelong learning, Informal learning, Teacher education, Mathematics education, media_common.cataloged_instance, Group work, European union, business, Psychology, Formal learning, media_common
Abstract: Private and professional life is more and more shaped by rapid changes in society and technology. That’s why continuous further education is essential in order to meet the new requirements. In the context of lifelong learning, this article focuses primarily on “learning to learn” as a key competence (European Union, 2018). Therefore, it is essential to develop the ability to self-regulated learning (Zimmerman, 2000) in the first phase of academic training and beyond. Learners must be able to plan, carry out and evaluate their learning process. In order to monitor it successfully, it also requires the ability to reflect. One instrument that can help learners to regulate their learning process is the ePortfolio (McAllister et al., 2008). In an ePortfolio learners can set their goals individually, document and reflect on their progress with the help of artefacts and thus assess their learning strategies and adapt them, if necessary. Futhermore, outcomes of informal learning can be presented within an ePortfolio as well as outcomes of formal learning activities. For example, in the field of teacher education ePortfolios are used quite widely. The ability to reflect one’s actions is an important aspect of professionalism, which helps teachers to improve their teaching (Schön, 1983). Therefore, it is important, as a prospective teacher, to be able to realistically assess one's own abilities and to know how to acquire new competencies. Teachers have to question their actions constantly and adapt them if necessary. In the German State of Baden-Württemberg keeping an ePortfolio is obligatory for students during the practical phases and is continued in the second phase of training, during the internship. A second field, where ePortfolio is gaining importance, is the academic continuing education. The Academy of Advanced Studies at the University of Konstanz offers academic programmes for professionals. A pilot project will be launched next semester in the part-time bachelor study programme in “Motor Neurorehabilitation” for qualified professional therapists in healthcare. Primarily, the implementation of an ePortfolio in this context aims at giving learners the opportunity to manage and personalise their own digital archive (collection of documents). Secondly, it enables the students to reflect more consciously the inputs and outputs collected - particularly during the time they will be attending their practical internships. Thus, the participants should develop a stronger reflective and critical thinking with regard to the acquired new methods and the experiences collected. Furthermore, the ePortofolio should facilitate group work and encourage interaction with other colleagues (peer review) and/or instructors. This paper discusses the possibilities of using ePortfolios in teacher training and in academic further education. Based on a theoretical concept for learning and professionalizing with ePortolios in higher education and life long learning, as mentioned before, the potentials in the different fields of application will be presented. Furthermore, we will point out the difficulties and challenges associated with the introduction of an ePortfolio. Finally, an outlook on what is planned for the further development of ePortfolio at the University of Konstanz will be given.
Published: 2021
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34. Food security and land use: The Ethiopian case

Author: Francesco Zecca and Marco d’Errico
Subjects: Economics and Econometrics, Food security, Land use, water supply, business.industry, Natural resource economics, Agriculture, Context (language use), food security, Investment (macroeconomics), Agricultural and Biological Sciences (miscellaneous), language.human_language, food policy, land grab, agricultural policy, Financial crisis, Food processing, Food policy, language, Agricultural policy, business, Agronomy and Crop Science
Abstract: From the financial crisis of 2008, international investors have addressed their attention to new investment and expansion opportunities and have acquired millions of hectares of land in various parts of the world. Developing Countries are the main target for such Large-Scale Land Acquisition (LSLA). While the adverse effects of these land grab are well known, their implications on food security have been less studied. In the context of an increasing disequilibrium between local food needs and international investors goals, the examining the potential adverse effects of LSLA on food security become an increasingly pressing matter. The paper illustrates an in-depth analysis on the impacts of LSLA on food security in Ethiopia. The results indicate that if the entire area of the acquired land is assumed to be used for domestic food production, it could feed around 7.1 million people.
Published: 2021
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35. A rare case of a giant circumflex coronary artery aneurysm 10 years after bentall surgery

Author: Leonardo Benelli, Alessandra Luciano, Vincenzo De Stasio, Monia Pasqualetto, Mario Laudazi, Marcello Chiocchi, Luigi Spiritigliozzi, Cecilia Cerimele, Luca Pugliese, Roberto Floris, Francesco Grimaldi, Matteo Cesareni, Gianluca Vanni, Daniele Morosetti, Francesco Garaci, Francesca D'Errico, Alessia Romeo, Alfredo Intorcia, Carlo Di Donna, Francesco Romeo, Federica Di Tosto, Francesco Paolo Sbordone, Carlotta Rellini, and Marco Di Luozzo
Subjects: medicine.medical_specialty, Percutaneous, R895-920, Case Report, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Medical physics. Medical radiology. Nuclear medicine, 0302 clinical medicine, Aneurysm, medicine.artery, Rare case, Ascending aorta, medicine, Coronary computed tomography angiography, Radiology, Nuclear Medicine and imaging, Coronary artery aneurysm, business.industry, medicine.disease, Surgery, medicine.anatomical_structure, Transcatheter aortic valve replacement, Circumflex coronary artery, business, 030217 neurology & neurosurgery, Artery
Abstract: In this paper, we describe a rare case of coronary artery aneurysms occasionally found on a pre interventional Coronary Computed Tomography Angiography performed on a 67-year-old man with a history of aneurysm of the ascending aorta previously treated with Bentall surgery, who arrived at our hospital to have a percutaneous valve-in-valve implantation procedure. Even though the patient was considered not eligible for the procedure, due to his many comorbidities, and conservatively managed, at 1-year followup his angiographic condition remained stable.
Published: 2021

36. Internal mammary lymph node siliconoma in absence of prosthesis rupture: a case series that raises concern for potential risk of overdiagnosis

Author: Marco Klinger, Alberto Testori, C. Tinterri, Flavio Milana, Gianluca Perroni, Valentina Errico, Andrea Lisa, and Emilia Marrazzo
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.disease, law.invention, medicine.anatomical_structure, Breast cancer, law, Biopsy, Breast implant, Medicine, Original Article, Surgery, Radiology, Implant, Overdiagnosis, Differential diagnosis, business, Lymph node, Internal Mammary Lymph Node
Abstract: Background Silicon migration after rupture is an adverse event of breast implant, whose risk increases with the aging of prosthesis. The exact prevalence of this complication remains unclear and reported data are inconsistent. In addition, microscopic diffusion of silicone gel through intact implant, known as gel bleeding, might verify thus complicating diagnosis. Although high cohesive gel has reduced the occurrence of gel bleeding, this phenomenon is still possible and its occurrence rate remains underestimated. If silicon droplets migrate in locoregional lymph node, a swelling that mimics recurrence can arise. Therefore, a risk of overdiagnosis is possible when clinicians rely only on imaging techniques. The aim of this study is to evaluate the actual prevalence of metastasis in internal mammary lymph node (IMLN) in presence of PET positive uptake and no prosthesis rupture. Methods We retrospectively evaluated our patient's records and selected those with intact breast implants and suspected relapse in IMLN that underwent biopsy, either surgical or imaging guided. All patients performed PET/CT scan showing pathological uptake in IMLNs. A breast magnetic resonance (MRI) or ultrasound (US) imaging confirmed a suspicious adenopathy and excluded prosthesis rupture. From 2015 to 2019 a total of nine patients underwent biopsy of the IMLN and only six of them met inclusion criteria. Results Four biopsies were CT-guided, two were surgical. Three patients (50%) were diagnosed with breast cancer relapse while two (33.3%) were found with siliconoma and one (16.7%) was inflammatory. Conclusions Siliconoma can occur even without evidence of capsule rupture, challenging the clinicians and leading to a risk of relapse over diagnosis. Echographic, MRI and nuclear medicine imaging criteria may be not sufficient in differential diagnosis. To overcome the issue, we suggest introducing into the clinical practice the biopsy of suspicious enlarged IMLN with minimally invasive technique.
Published: 2021
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37. Not Frail and Elderly: How Invasive Can We Go in This Different Type of Adult Spinal Deformity Patient?

Author: Tina Raman, Frank J. Schwab, Katherine E. Pierce, Burhan Janjua, Themistocles S. Protopsaltis, Virginie Lafage, Renaud Lafage, Thomas J. Errico, Ammar Adenwalla, Peter G. Passias, Aaron J. Buckland, Sara Naessig, Waleed Ahmad, Lara Passfall, Nicholas O'Malley, Oscar Krol, Brooke K. O'Connell, Bassel G. Diebo, Nicholas Kummer, Constance Maglaras, and Shaleen N. Vira
Subjects: Adult, Reoperation, medicine.medical_specialty, Databases, Factual, Frailty, business.industry, Frailty Index, Odds ratio, Logistic regression, Spine, Postoperative Complications, Internal medicine, Quality of Life, Spinal deformity, medicine, Humans, Orthopedics and Sports Medicine, In patient, Neurology (clinical), Major complication, Complication, business, Aged, Retrospective Studies, Balance (ability)
Abstract: STUDY DESIGN Retrospective review of a single-center spine database. OBJECTIVE Investigate the intersections of chronological age and physiological age via frailty to determine the influence of surgical invasiveness on patient outcomes. SUMMARY OF BACKGROUND DATA Frailty is a well-established factor in preoperative risk stratification and prediction of postoperative outcomes. The surgical profile of operative patients with adult spinal deformity (ASD) who present as elderly and not frail (NF) has yet to be investigated. Our aim was to examine the surgical profile and outcomes of patients with ASD who were NF and elderly. METHODS Patients with ASD 18 years or older, four or greater levels fused, with baseline (BL) and follow-up data were included. Patients were categorized by ASD frailty index: NF, Frail (F), severely frail (SF]. An elderly patient was defined as 70 years or older. Patients were grouped into NF/elderly and F/elderly. SRS-Schwab modifiers were assessed at BL and 1 year (0, +, ++). Logistic regression analysis assessed the relationship between increasing invasiveness, no reoperations, or major complications, and improvement in SRS-Schwab modifiers [Good Outcome]. Decision tree analysis assessed thresholds for an invasiveness risk/benefit cutoff point. RESULTS A total of 598 patients with ASD included (55.3 yr, 59.7% F, 28.3 kg/m2). 29.8% of patients were older than 70 years. At BL, 51.3% of patients were NF, 37.5% F, and 11.2% SF. Sixty-sis (11%) patients were NF and elderly. About 24.2% of NF-elderly patients improved in SRS-Schwab by 1 year and had no reoperation or complication postoperatively. Binary regression analysis found a relationship between worsening SRS-Schwab, postop complication, and reoperation with invasiveness score (odds ratio: 1.056 [1.01-1.102], P = 0.011). Risk/benefit cut-off was 10 (P = 0.004). Patients below this threshold were 7.9 (2.2-28.4) times more likely to have a Good Outcome. 156 patients were elderly and F/SF with 16.7% having good outcome, with a risk/benefit cut-off point of less than 8 (4.4 [2.2-9.0], P
Published: 2021
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38. 3GPP Standardized 5G Channel Model for IIoT Scenarios: A Survey

Author: Pan Tang, Henrik Asplund, Tommi Jamsa, Leszek Raschkowski, Yi Zheng, Jianwu Dou, Raffaele D'Errico, Tao Jiang, Jianhua Zhang, Lei Tian, and Publica
Subjects: Computer Networks and Communications, Computer science, business.industry, 05 social sciences, Real-time computing, 050801 communication & media studies, 020206 networking & telecommunications, 02 engineering and technology, Computer Science Applications, Delay spread, Radio propagation, 0508 media and communications, Hardware and Architecture, Antenna height considerations, Signal Processing, 0202 electrical engineering, electronic engineering, information engineering, Clutter, Wireless, Path loss, business, 5G, Information Systems, Communication channel
Abstract: Industrial Internet of Things (IIoT) is an emerging area that fifth-generation (5G) mobile communication system penetrates industrial manufacturing applications. The indoor factory has larger space and there are a lot of metal machine tools distributed in it, which makes its radio propagation characteristics and corresponding channel models significantly different from those of the indoor office and indoor hotspot. To support the design and the evaluation of the IIoT techniques, the 3rd Generation Partnership Project (3GPP) released the first 5G IIoT standard model in October 2019. In this article, we give a detailed explanation of this IIoT model and compare it with other indoor models. First, we introduce the standardization of 3GPP IIoT channel model and its motivation. Second, four IIoT subscenarios, which are classified according to the clutter density and antenna height, are described. Third, the potential frequency bands of 5G IIoT are summarized. Fourth, the models of channel parameters, including the path loss and the line-of-sight (LOS) probability, the root mean-square (RMS) delay spread, and the angular spread, are given. Among them, the models of path loss and LOS probability take the antenna height and clutter density into consideration. The model of RMS delay spread changes from frequency-dependent to volume-dependent in order to catch the size variation of factories. Finally, two newly added key channel characteristics, dual mobility and absolute time of arrival, which help to describe the robot movement and positioning, are also presented.
Published: 2021
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39. Anatomic features in SCAD assessed by CCT: A propensity score matching case control study

Author: F. Di Tosto, Leonardo Benelli, Francesco Paolo Sbordone, M. Di Luozzo, Marcello Chiocchi, Valentina Meschini, Saverio Muscoli, Matteo Presicce, Roberto Floris, Luigi Spiritigliozzi, Francesca D'Errico, Roberto Verzicco, Francesca Ricci, V. De Stasio, Francesco Grimaldi, Armando Ugo Cavallo, Monia Pasqualetto, Luca Pugliese, C. Di Donna, and Francesco Romeo
Subjects: Male, medicine.medical_specialty, Computed Tomography Angiography, Coronary Vessel Anomalies, Population, 030204 cardiovascular system & hematology, Coronary Angiography, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Internal medicine, medicine, Humans, Vascular Diseases, Circumflex, Risk factor, Propensity Score, education, Retrospective Studies, education.field_of_study, business.industry, Age Factors, Middle Aged, Coronary Vessels, Middle age, Coronary arteries, medicine.anatomical_structure, Case-Control Studies, Hemorheology, Propensity score matching, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, Scad, business, Artery
Abstract: Spontaneous coronary artery dissection (SCAD) may occur in middle age population without any cardiovascular risk factor. We retrospectively evaluated anatomic features of 11 patients with SCAD using a coronary arteries computed tomography (CCT), compared to age and sex balanced patients who underwent CCT.CCT was performed in 11 patients (7 females and 4 males) as follow-up in patients with SCAD (left anterior descending - LAD or circumflex artery - Cx) and compared, using the propensity score matching analysis, with 11 healthy patients. Several anatomic features were evaluated: Left main (LM) length, angle between descending coronary artery (LAD) and its first branch, angle between LAD and LM, distance from the annulus to RCA (a-RCA distance) and LM (a-LM distance) ostia and their ratio; ratio between LM length and length a-LM and tortuosity score of the vessel with SCAD. A fluid dynamic analysis has been performed to evaluate the effects on shear stress of vessels wall.LM length was significantly shorter in patients with SCAD versus healthy subjects (P=0.01) as well as LM length/a-LM (P=0.03) and the angle between LAD and the first adjacent branch was sharper (P0.01). Tortuosity score showed a statistically significant difference between groups (P0.001). Fluid dynamic analysis demonstrates that, in SCAD group, an angle90 degree is present at the first bifurcation and it can be a cause of increased strain on vessel wall in patients with high tortuosity of coronary artery.Tortuosity and angle between the LAD and the adjacent arterial branch combined may determine increased shear stress on the vessel wall that increases the risk of SCAD.
Published: 2021
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40. The Role of [18F]Fluciclovine PET/CT in the Characterization of High-Risk Primary Prostate Cancer: Comparison with [11C]Choline PET/CT and Histopathological Analysis

Author: Lorenzo Maltoni, Irene Bossert, Lucia Zanoni, Cristina Nanni, Antonietta D'Errico, Antonella Matti, Cristina Fonti, Michelangelo Fiorentino, Cristian Vincenzo Pultrone, Francesca Giunchi, Eugenio Brunocilla, Filippo Lodi, Lorenzo Bianchi, Stefano Fanti, Riccardo Schiavina, Riccardo Mei, Zanoni L., Mei R., Bianchi L., Giunchi F., Maltoni L., Pultrone C.V., Nanni C., Bossert I., Matti A., Schiavina R., Fiorentino M., Fonti C., Lodi F., D'errico A., Brunocilla E., Fanti S., and Zanoni L, Mei R, Bianchi L, Giunchi F, Maltoni L, Pultrone CV, Nanni C, Bossert I, Matti A, Schiavina R, Fiorentino M, Fonti C, Lodi F, D'Errico A, Brunocilla E, Fanti S.
Subjects: Cancer Research, medicine.medical_specialty, medicine.medical_treatment, [11C]Choline, high risk, Malignancy, lcsh:RC254-282, Article, 030218 nuclear medicine & medical imaging, Lesion, 03 medical and health sciences, Prostate cancer, primary prostate cancer, 0302 clinical medicine, staging, Prostate, medicine.artery, medicine, PET-CT, [18F]Fluciclovine PET/CT, business.industry, Prostatectomy, Abdominal aorta, C]Choline, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, F]Fluciclovine PET/CT, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Histopathology, medicine.symptom, Nuclear medicine, business, [
Abstract: The primary aim of the study was to evaluate the role of [18F]Fluciclovine PET/CT in the characterization of intra-prostatic lesions in high-risk primary PCa patients eligible for radical prostatectomy, in comparison with conventional [11C]Choline PET/CT and validated by prostatectomy pathologic examination. Secondary aims were to determine the performance of PET semi-quantitative parameters (SUVmax, target-to-background ratios [TBRs], using abdominal aorta, bone marrow and liver as backgrounds) for malignant lesion detection (and best cut-off values) and to search predictive factors of malignancy. A six sextants prostate template was created and used by PET readers and pathologists for data comparison and validation. PET visual and semi-quantitative analyses were performed: for instance, patient-based, blinded to histopathology, subsequently lesion-based, un-blinded, according to the pathology reference template. Among 19 patients included (mean age 63 years, 89% high and 11% very-high-risk, mean PSA 9.15 ng/mL), 45 malignant and 31 benign lesions were found and 19 healthy areas were selected (n = 95). For both tracers, the location of the “blinded” prostate SUVmax matched with the lobe of the lesion with the highest pGS in 17/19 cases (89%). There was direct correlation between [18F]Fluciclovine uptake values and pISUP. Overall, lesion-based (n = 95), the performance of PET semiquantitative parameters, with either [18F]Fluciclovine or [11C]Choline, in detecting either malignant/ISUP2-5/ISUP4-5 PCa lesions, was moderate and similar (AUCs ≥ 0.70) but still inadequate (AUCs ≤ 0.81) as a standalone staging procedure. A [18F]Fluciclovine TBR-L3 ≥ 1.5 would depict a clinical significant lesion with a sensitivity and specificity of 85% and 68% respectively, whereas a SUVmax cut-off value of 4 would be able to identify a ISUP 4-5 lesion in all cases (sensitivity 100%), although with low specificity (52%). TBRs (especially with threshold significantly higher than aorta and slightly higher than bone marrow), may be complementary to implement malignancy targeting.
Published: 2021

41. Mitral Arcade Causing Severe Stenosis in an Adult Patient

Author: Aldo Milano, Tommaso Acquaviva, Nicola Di Bari, Nicola Vitale, and Antonio D’Errico Ramirez
Subjects: Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Mitral Valve Insufficiency, Constriction, Pathologic, medicine.disease, Mitral valve stenosis, Internal medicine, Cardiology, Humans, Mitral Valve, Mitral Valve Stenosis, Medicine, Severe stenosis, Cardiology and Cardiovascular Medicine, business
Published: 2022
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42. The impact of DAA-mediated HCV eradication on CD4+ and CD8+ T lymphocyte trajectories in HIV/HCV coinfected patients: Data from the ICONA Foundation Cohort

Author: Bandera, A., Lorenzini, P., Taramasso, L., Cozzi-Lepri, A., Lapadula, G., Mussini, C., Saracino, A., Ceccherini-Silberstein, F., Puoti, M., Quiros-Roldan, E., Montagnani, F., Antinori, A., d'Arminio Monforte, A., Gori, A., Andreoni, M., Castagna, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Marchetti, G. C., Rezza, G., von Shloesser, F., Viale, P., Girardi, E., Lo Caputo, S., Maggiolo, F., Perno, C. F., Bai, F., Bonora, S., Borderi, M., Calcagno, A., Capobianchi, M. R., Cicalini, S., Cingolani, A., Cinque, P., Di Biagio, A., Gagliardini, R., Gianotti, N., Guaraldi, G., Lichtner, M., Lai, A., Madeddu, G., Marchetti, G., Merlini, E., Nozza, S., Piconi, S., Pinnetti, C., Rossotti, R., Rusconi, S., Santoro, M. M., Sarmati, L., Spagnuolo, V., Svicher, V., Fanti, I., Galli, L., Rodano', A., Macchia, M., Tavelli, A., Bove, A., Camposeragna, A., Errico, M., Manfredini, M., Perziano, A., Calvino, V., Carletti, F., Carrara, S., Di Caro, A., Graziano, S., Petroni, F., Prota, G., Truffa, S., Giacometti, A., Costantini, A., Barocci, V., Angarano, G., Monno, L., Milano, E., Suardi, C., Donati, V., Verucchi, G., Castelnuovo, F., Minardi, C., Menzaghi, B., Abeli, C., Chessa, L., Pes, F., Cacopardo, B., Celesia, B., Vecchiet, J., Falasca, K., Pan, A., Lorenzotti, S., Sighinolfi, L., Segala, D., Blanc, P., Vichi, F., Cassola, G., Bassetti, M., Alessandrini, A., Bobbio, N., Mazzarello, G., Fondaco, L., Bonfanti, P., Molteni, C., Chiodera, A., Milini, P., Nunnari, G., Pellicano, G., Rizzardini, G., Cannizzo, E. S., Moioli, M. C., Piolini, R., Bernacchia, D., Poli, A., Tincati, C., Puzzolante, C., Migliorino, C., Sangiovanni, V., Borgia, G., Esposito, V., Di Flumeri, G., Gentile, I., Rizzo, V., Cattelan, A. M., Marinello, S., Cascio, A., Trizzino, M., Francisci, D., Schiaroli, E., Parruti, G., Sozio, F., Lazzaretti, C., Corsini, R., Cristaudo, A., Vullo, V., Acinapura, R., Lamonica, S., Capozzi, M., Mondi, A., Rivano Capparuccia, M., Iaiani, G., Latini, A., Onnelli, G., Plazzi, M. M., De Girolamo, G., Vergori, A., Cecchetto, M., Viviani, F., De Vito, A., Rossetti, B., Franco, A., Fontana Del Vecchio, R., Di Giuli, C., Caramello, P., Orofino, G. C., Sciandra, M., Londero, A., Manfrin, V., Battagin, G., Starnini, G., Ialungo, A., Bandera A., Lorenzini P., Taramasso L., Cozzi-Lepri A., Lapadula G., Mussini C., Saracino A., Ceccherini-Silberstein F., Puoti M., Quiros-Roldan E., Montagnani F., Antinori A., d'Arminio Monforte A., Gori A., Andreoni M., Castagna A., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Marchetti G.C., Rezza G., von Shloesser F., Viale P., Girardi E., Lo Caputo S., Maggiolo F., Perno C.F., Bai F., Bonora S., Borderi M., Calcagno A., Capobianchi M.R., Cicalini S., Cingolani A., Cinque P., Di Biagio A., Gagliardini R., Gianotti N., Guaraldi G., Lichtner M., Lai A., Madeddu G., Merlini E., Nozza S., Piconi S., Pinnetti C., Rossotti R., Rusconi S., Santoro M.M., Sarmati L., Spagnuolo V., Svicher V., Fanti I., Galli L., Rodano' A., Macchia M., Tavelli A., Bove A., Camposeragna A., Errico M., Manfredini M., Perziano A., Calvino V., Carletti F., Carrara S., Di Caro A., Graziano S., Petroni F., Prota G., Truffa S., Giacometti A., Costantini A., Barocci V., Angarano G., Monno L., Milano E., Suardi C., Donati V., Verucchi G., Castelnuovo F., Minardi C., Menzaghi B., Abeli C., Chessa L., Pes F., Cacopardo B., Celesia B., Vecchiet J., Falasca K., Pan A., Lorenzotti S., Sighinolfi L., Segala D., Blanc P., Vichi F., Cassola G., Bassetti M., Alessandrini A., Bobbio N., Mazzarello G., Fondaco L., Bonfanti P., Molteni C., Chiodera A., Milini P., Nunnari G., Pellicano G., Rizzardini G., Cannizzo E.S., Moioli M.C., Piolini R., Bernacchia D., Poli A., Tincati C., Puzzolante C., Migliorino C., Sangiovanni V., Borgia G., Esposito V., Di Flumeri G., Gentile I., Rizzo V., Cattelan A.M., Marinello S., Cascio A., Trizzino M., Francisci D., Schiaroli E., Parruti G., Sozio F., Lazzaretti C., Corsini R., Qqwdreoni Q., Cristaudo A., Vullo V., Acinapura R., Lamonica S., Capozzi M., Mondi A., Rivano Capparuccia M., Iaiani G., Latini A., Onnelli G., Plazzi M.M., De Girolamo G., Vergori A., Cecchetto M., Viviani F., De Vito A., Rossetti B., Franco A., Fontana Del Vecchio R., Di Giuli C., Caramello P., Orofino G.C., Sciandra M., Londero A., Manfrin V., Battagin G., Starnini G., Ialungo A., Bandera, A, Lorenzini, P, Taramasso, L, Cozzi-Lepri, A, Lapadula, G, Mussini, C, Saracino, A, Ceccherini-Silberstein, F, Puoti, M, Quiros-Roldan, E, Montagnani, F, Antinori, A, d'Arminio Monforte, A, Gori, A, Andreoni, M, Castagna, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Marchetti, G, Rezza, G, von Shloesser, F, Viale, P, Girardi, E, Lo Caputo, S, Maggiolo, F, Perno, C, Bai, F, Bonora, S, Borderi, M, Calcagno, A, Capobianchi, M, Cicalini, S, Cingolani, A, Cinque, P, Di Biagio, A, Gagliardini, R, Gianotti, N, Guaraldi, G, Lichtner, M, Lai, A, Madeddu, G, Merlini, E, Nozza, S, Piconi, S, Pinnetti, C, Rossotti, R, Rusconi, S, Santoro, M, Sarmati, L, Spagnuolo, V, Svicher, V, Fanti, I, Galli, L, Rodano', A, Macchia, M, Tavelli, A, Bove, A, Camposeragna, A, Errico, M, Manfredini, M, Perziano, A, Calvino, V, Carletti, F, Carrara, S, Di Caro, A, Graziano, S, Petroni, F, Prota, G, Truffa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Monno, L, Milano, E, Suardi, C, Donati, V, Verucchi, G, Castelnuovo, F, Minardi, C, Menzaghi, B, Abeli, C, Chessa, L, Pes, F, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolfi, L, Segala, D, Blanc, P, Vichi, F, Cassola, G, Bassetti, M, Alessandrini, A, Bobbio, N, Mazzarello, G, Fondaco, L, Bonfanti, P, Molteni, C, Chiodera, A, Milini, P, Nunnari, G, Pellicano, G, Rizzardini, G, Cannizzo, E, Moioli, M, Piolini, R, Bernacchia, D, Poli, A, Tincati, C, Puzzolante, C, Migliorino, C, Sangiovanni, V, Borgia, G, Esposito, V, Di Flumeri, G, Gentile, I, Rizzo, V, Cattelan, A, Marinello, S, Cascio, A, Trizzino, M, Francisci, D, Schiaroli, E, Parruti, G, Sozio, F, Lazzaretti, C, Corsini, R, Qqwdreoni, Q, Cristaudo, A, Vullo, V, Acinapura, R, Lamonica, S, Capozzi, M, Mondi, A, Rivano Capparuccia, M, Iaiani, G, Latini, A, Onnelli, G, Plazzi, M, De Girolamo, G, Vergori, A, Cecchetto, M, Viviani, F, De Vito, A, Rossetti, B, Franco, A, Fontana Del Vecchio, R, Di Giuli, C, Caramello, P, Orofino, G, Sciandra, M, Londero, A, Manfrin, V, Battagin, G, Starnini, G, Ialungo, A, Bandera, A., Lorenzini, P., Taramasso, L., Cozzi-Lepri, A., Lapadula, G., Mussini, C., Saracino, A., Ceccherini-Silberstein, F., Puoti, M., Quiros-Roldan, E., Montagnani, F., Antinori, A., d'Arminio Monforte, A., Gori, A., Andreoni, M., Castagna, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Marchetti, G. C., Rezza, G., von Shloesser, F., Viale, P., Girardi, E., Lo Caputo, S., Maggiolo, F., Perno, C. F., Bai, F., Bonora, S., Borderi, M., Calcagno, A., Capobianchi, M. R., Cicalini, S., Cingolani, A., Cinque, P., Di Biagio, A., Gagliardini, R., Gianotti, N., Guaraldi, G., Lichtner, M., Lai, A., Madeddu, G., Merlini, E., Nozza, S., Piconi, S., Pinnetti, C., Rossotti, R., Rusconi, S., Santoro, M. M., Sarmati, L., Spagnuolo, V., Svicher, V., Fanti, I., Galli, L., Rodano', A., Macchia, M., Tavelli, A., Bove, A., Camposeragna, A., Errico, M., Manfredini, M., Perziano, A., Calvino, V., Carletti, F., Carrara, S., Di Caro, A., Graziano, S., Petroni, F., Prota, G., Truffa, S., Giacometti, A., Costantini, A., Barocci, V., Angarano, G., Monno, L., Milano, E., Suardi, C., Donati, V., Verucchi, G., Castelnuovo, F., Minardi, C., Menzaghi, B., Abeli, C., Chessa, L., Pes, F., Cacopardo, B., Celesia, B., Vecchiet, J., Falasca, K., Pan, A., Lorenzotti, S., Sighinolfi, L., Segala, D., Blanc, P., Vichi, F., Cassola, G., Bassetti, M., Alessandrini, A., Bobbio, N., Mazzarello, G., Fondaco, L., Bonfanti, P., Molteni, C., Chiodera, A., Milini, P., Nunnari, G., Pellicano, G., Rizzardini, G., Cannizzo, E. S., Moioli, M. C., Piolini, R., Bernacchia, D., Poli, A., Tincati, C., Puzzolante, C., Migliorino, C., Sangiovanni, V., Borgia, G., Esposito, V., Di Flumeri, G., Gentile, I., Rizzo, V., Cattelan, A. M., Marinello, S., Cascio, A., Trizzino, M., Francisci, D., Schiaroli, E., Parruti, G., Sozio, F., Lazzaretti, C., Corsini, R., Qqwdreoni, Q., Cristaudo, A., Vullo, V., Acinapura, R., Lamonica, S., Capozzi, M., Mondi, A., Rivano Capparuccia, M., Iaiani, G., Latini, A., Onnelli, G., Plazzi, M. M., De Girolamo, G., Vergori, A., Cecchetto, M., Viviani, F., De Vito, A., Rossetti, B., Franco, A., Fontana Del Vecchio, R., Di Giuli, C., Caramello, P., Orofino, G. C., Sciandra, M., Londero, A., Manfrin, V., Battagin, G., Starnini, G., and Ialungo, A.
Subjects: CD4-Positive T-Lymphocytes, HIV Infections, Hepacivirus, CD8-Positive T-Lymphocytes, Gastroenterology, Settore MED/07, chemistry.chemical_compound, 0302 clinical medicine, Cd8 t lymphocyte, HIV Infection, 030212 general & internal medicine, Coinfection, CD4, CD8, DAA, HCV/HIV, immune activation, Hcv clearance, virus diseases, Middle Aged, Hepatitis C, Infectious Diseases, medicine.anatomical_structure, CD4-Positive T-Lymphocyte, Cohort, 030211 gastroenterology & hepatology, Female, CD4, CD8, DAA, HCV/HIV, immune activation, Human, Immune activation, medicine.medical_specialty, T cell, Antiviral Agents, NO, 03 medical and health sciences, Virology, Internal medicine, medicine, Humans, In patient, Antiviral Agent, Hepaciviru, Hepatology, business.industry, Ribavirin, CD8-Positive T-Lymphocyte, CD4 Lymphocyte Count, chemistry, business
Abstract: HCV infection has been hypothesized as a contributor of poor CD4+ recovery in patients living with HIV (PLWHIV). Aim of this study was to evaluate CD4+, CD8+ cells and CD4/CD8 ratio trends before and after HCV treatment with direct acting agents (DAA) in PLWHIV. HIV/HCV patients enrolled in ICONA and HepaICONA cohorts with HIV-RNA≤50copies/ml who achieved a sustained viral response after DAA treatment were studied. A linear regression model was used to investigate CD4+, CD8+ and CD4/CD8 changes 12months before and after DAA treatment. A total of 939 HIV/HCV patients were included, 225 (24.0%) female, median age: 53years (IQR 50–56). At DAA initiation, CD4+ T cell count was 12.5kPa. Trends of CD4+ and CD4/CD8 ratio were similar before and after DAA in all study populations (CD4+ change +17.6 cells/mm3 (95%CI −33.5; 69.4, p=0.494); CD4/CD8 change 0.013 (95%CI −0.061; 0.036, p=0.611). However, patients treated with ribavirin (RBV)-free DAA showed a significant decrease in CD8+ cells (−204.3 cells/mm3, 95%CI −375.0;-33.4, p=0.019), while patients treated with RBV experienced CD8+ cell increase (+141.2 cells/mm3, 95%CI 40.3; 242.1, p=0.006). In conclusion, HCV eradication following DAA treatment does not seem to have an impact on CD4+ T cell recovery in PLWHIV. However, a fast decline of CD8+T cells has been observed in patients treated without RBV, suggesting a favourable effect of HCV clearance on the general state of immune activation.
Published: 2021

43. Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas

Author: Roberto Caronna, Enrico Solcia, Giuseppe Neri, Augusto Orlandi, Michele Martino, Catherine Klersy, Carolina Ciacci, Antonietta D'Errico, Ada Maria Florena, Giovanni Monteleone, Giacomo Caio, Paolo Giuffrida, Gianluca M. Sampietro, Luca Elli, Stefano Ferrero, Maria D'Armiento, G. Solina, Fausto Sessa, Paolo Pedrazzoli, Giuseppe Amodeo, Elena Biletta, Barbara Oreggia, Fabiana Zingone, Deborah Malvi, Claudia Mescoli, Andrea Pietrabissa, Alessandro Vanoli, Camilla Guerini, Giovanni Arpa, Anna D'Odorico, Gabriella Nesi, Massimo Rugge, Fernando Rizzello, Roberto De Giorgio, Federica Grillo, Renato Cannizzaro, Umberto Volta, Livia Biancone, Gilberto Poggioli, Vincenzo Villanacci, Luca Reggiani Bonetti, Maria Cristina Macciomei, Donatella Santini, Sandro Ardizzone, Vincenzo Canzonieri, Rachele Ciccocioppo, Francesco Tonelli, Gino Roberto Corazza, Valeria Barresi, Flavio Caprioli, Roberto Fiocca, Antonio Di Sabatino, Ombretta Luinetti, Giovanni Latella, Paolo Fociani, Marco Paulli, Antonio Calabrò, Antonino Giulio Giannone, Maurizio Vecchi, Renata D'Incà, Aroldo Rizzo, Antonio Ciardi, Marco Vincenzo Lenti, Vanoli A., Grillo F., Guerini C., Neri G., Arpa G., Klersy C., Nesi G., Giuffrida P., Sampietro G., Ardizzone S., Fociani P., Fiocca R., Latella G., Sessa F., D'Errico A., Malvi D., Mescoli C., Rugge M., Ferrero S., Poggioli G., Rizzello F., Macciomei M.C., Santini D., Volta U., De Giorgio R., Caio G., Calabro A., Ciacci C., D'Armiento M., Rizzo A., Solina G., Martino M., Tonelli F., Villanacci V., Cannizzaro R., Canzonieri V., Florena A.M., Biancone L., Monteleone G., Caronna R., Ciardi A., Elli L., Caprioli F., Vecchi M., D'Inca R., Zingone F., D'Odorico A., Lenti M.V., Oreggia B., Reggiani Bonetti L., Giannone A.G., Orlandi A., Barresi V., Ciccocioppo R., Amodeo G., Biletta E., Luinetti O., Pedrazzoli P., Pietrabissa A., Corazza G.R., Solcia E., Paulli M., Di Sabatino A., Vanoli, A., Grillo, F., Guerini, C., Neri, G., Arpa, G., Klersy, C., Nesi, G., Giuffrida, P., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Ferrero, S., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Reggiani Bonetti, L., Giannone, A. G., Orlandi, A., Barresi, V., Ciccocioppo, R., Amodeo, G., Biletta, E., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Corazza, G. R., Solcia, E., Paulli, M., Di Sabatino, A., Vanoli, Alessandro, Grillo, Federica, Guerini, Camilla, Neri, Giuseppe, Arpa, Giovanni, Klersy, Catherine, Nesi, Gabriella, Giuffrida, Paolo, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D'Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Ferrero, Stefano, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C, Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D'Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada Maria, Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D'Incà, Renata, Zingone, Fabiana, D'Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Reggiani Bonetti, Luca, Giannone, Antonino Giulio, Orlandi, Augusto, Barresi, Valeria, Ciccocioppo, Rachele, Amodeo, Giuseppe, Biletta, Elena, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Corazza, Gino Roberto, Solcia, Enrico, Paulli, Marco, and Di Sabatino, Antonio
Subjects: Male, Oncology, Colorectal cancer, DNA Mismatch Repair, COLORECTAL-CANCER, Settore MED/12, 0302 clinical medicine, PMS2, small bowel adenocarcinoma, Mismatch Repair Endonuclease PMS2, 0303 health sciences, Prognosis, MMR, MutS Homolog 2 Protein, CARCINOMAS, 030220 oncology & carcinogenesis, immunohistochemistry, Mismatch Repair Status, small bowel adenocarcinoma, Female, Microsatellite Instability, DNA mismatch repair, MutL Protein Homolog 1, Colorectal Neoplasms, stage II, medicine.medical_specialty, high-risk pathologic features, Humans, Adenocarcinoma, mismatch repair status, NO, 03 medical and health sciences, small bowel carcinoma, histotype, Internal medicine, Translational Research, medicine, 030304 developmental biology, small bowel adenocarcinomas, business.industry, Cancer, Microsatellite instability, Mismatch Repair Protein, Adenocarcinoma IBD Cancer, medicine.disease, digestive system diseases, MSH6, CONSENSUS, small bowel carcinoma, MMR, immunohistochemistry, Mismatch repair, Small bowel Adenocarcinoma, MSH2, Mismatch repair status, Surgery, business
Abstract: Background Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guidelines, criteria for selecting patients with stage II small bowel adenocarcinoma to receive adjuvant chemotherapy are provided, and they are mainly extrapolated from studies on colorectal cancer. Patients and Methods In the present study, we aimed to verify whether mismatch repair deficiency phenotype, high-risk pathologic features (including T4, positive resection margins and a low number of lymph nodes harvested), as well as tumor histologic subtype, were associated with cancer-specific survival in 66 stage II non-ampullary small bowel adenocarcinoma patients, collected through the Small Bowel Cancer Italian Consortium. A central histopathology review was performed. Mismatch repair deficiency was tested by immunohistochemistry for MLH1, MSH2, MSH6 and PMS2, and confirmed by polymerase chain reaction for microsatellite instability. Results We identified mismatch repair deficiency, glandular/medullary histologic subtype, and celiac disease as significant predictors of favorable cancer-specific survival using univariable analysis with retained significance in bivariable models adjusted for pT stage. Among the high-risk features, only T4 showed a significant association with an increased risk of death; however, its prognostic value was not independent of mismatch repair status. Conclusions Mismatch repair protein expression, histologic subtype, association with celiac disease, and, in the mismatch repair proficient subset only, T stage, may help identify patients who may benefit from adjuvant chemotherapy. Graphic Abstract
Published: 2021

44. Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis

Author: Johnson, JO, Chia, R, Miller, DE, Li, R, Kumaran, R, Abramzon, Y, Alahmady, N, Renton, AE, Topp, SD, Gibbs, JR, Cookson, MR, Sabir, MS, Dalgard, CL, Troakes, C, Jones, AR, Shatunov, A, Iacoangeli, A, Al Khleifat, A, Ticozzi, N, Silani, V, Gellera, C, Blair, IP, Dobson-Stone, C, Kwok, JB, Bonkowski, ES, Palvadeau, R, Tienari, PJ, Morrison, KE, Shaw, PJ, Al-Chalabi, A, Brown, RH, Calvo, A, Mora, G, Al-Saif, H, Gotkine, M, Leigh, F, Chang, IJ, Perlman, SJ, Glass, I, Scott, AI, Shaw, CE, Basak, AN, Landers, JE, Chiò, A, Crawford, TO, Smith, BN, Traynor, BJ, Fallini, C, Gkazi, AS, Scotter, EL, Kenna, KP, Keagle, P, Tiloca, C, Vance, C, Colombrita, C, King, A, Pensato, V, Castellotti, B, Baas, F, ten Asbroek, ALMA, McKenna-Yasek, D, McLaughlin, RL, Polak, M, Asress, S, Esteban-Pérez, J, Stevic, Z, D’Alfonso, S, Mazzini, L, Comi, GP, Del Bo, R, Ceroni, M, Gagliardi, S, Querin, G, Bertolin, C, van Rheenen, W, Rademakers, R, van Blitterswijk, M, Lauria, G, Duga, S, Corti, S, Cereda, C, Corrado, L, Sorarù, G, Williams, KL, Nicholson, GA, Leblond-Manry, C, Rouleau, GA, Hardiman, O, Veldink, JH, van den Berg, LH, Pall, H, Turner, MR, Talbot, K, Taroni, F, García-Redondo, A, Wu, Z, Glass, JD, Ratti, A, Adeleye, A, Soltis, AR, Alba, C, Viollet, C, Bacikova, D, Hupalo, DN, Sukumar, G, Pollard, HB, Wilkerson, MD, Martinez, EM, Ahmed, S, Arepalli, S, Baloh, RH, Bowser, R, Brady, CB, Brice, A, Broach, J, Campbell, RH, Camu, W, Cooper-Knock, J, Ding, J, Drepper, C, Drory, VE, Dunckley, TL, Eicher, JD, England, BK, Faghri, F, Feldman, E, Floeter, MK, Fratta, P, Geiger, JT, Gerhard, G, Gibson, SB, Hardy, J, Harms, MB, Heiman-Patterson, TD, Hernandez, DG, Jansson, L, Kirby, J, Kowall, NW, Laaksovirta, H, Landeck, N, Landi, F, Le Ber, I, Lumbroso, S, MacGowan, DJL, Maragakis, NJ, Mouzat, K, Murphy, NA, Myllykangas, L, Nalls, MA, Orrell, RW, Ostrow, LW, Pamphlett, R, Pickering-Brown, S, Pioro, EP, Pletnikova, O, Pliner, HA, Pulst, SM, Ravits, JM, Rivera, A, Robberecht, W, Rogaeva, E, Rollinson, S, Rothstein, JD, Scholz, SW, Sendtner, M, Sidle, KC, Simmons, Z, Singleton, AB, Smith, N, Stone, DJ, Troncoso, JC, Valori, M, Van Damme, P, Van Deerlin, VM, Van Den Bosch, L, Zinman, L, Angelocola, SM, Ausiello, FP, Barberis, M, Bartolomei, I, Battistini, S, Bersano, E, Bisogni, G, Borghero, G, Brunetti, M, Cabona, C, Canale, F, Canosa, A, Cantisani, TA, Capasso, M, Caponnetto, C, Cardinali, P, Carrera, P, Casale, F, Colletti, T, Conforti, FL, Conte, A, Conti, E, Corbo, M, Cuccu, S, Dalla Bella, E, D’Errico, E, DeMarco, G, Dubbioso, R, Ferrarese, C, Ferraro, PM, Filippi, M, Fini, N, Floris, G, Fuda, G, Gallone, S, Gianferrari, G, Giannini, F, Grassano, M, Greco, L, Iazzolino, B, Introna, A, La Bella, V, Lattante, S, Liguori, R, Logroscino, G, Logullo, FO, Lunetta, C, Mandich, P, Mandrioli, J, Manera, U, Manganelli, F, Marangi, G, Marinou, K, Marrosu, MG, Martinelli, I, Messina, S, Moglia, C, Mosca, L, Murru, MR, Origone, P, Passaniti, C, Petrelli, C, Petrucci, A, Pozzi, S, Pugliatti, M, Quattrini, A, Ricci, C, Riolo, G, Riva, N, Russo, M, Sabatelli, M, Salamone, P, Salivetto, M, Salvi, F, Santarelli, M, Sbaiz, L, Sideri, R, Simone, I, Simonini, C, Spataro, R, Tanel, R, Tedeschi, G, Ticca, A, Torriello, A, Tranquilli, S, Tremolizzo, L, Trojsi, F, Vasta, R, Vacchiano, V, Vita, G, Volanti, P, Zollino, M, Zucchi, E, Johnson J.O., Chia R., Miller D.E., Li R., Kumaran R., Abramzon Y., Alahmady N., Renton A.E., Topp S.D., Gibbs J.R., Cookson M.R., Sabir M.S., Dalgard C.L., Troakes C., Jones A.R., Shatunov A., Iacoangeli A., Al Khleifat A., Ticozzi N., Silani V., Gellera C., Blair I.P., Dobson-Stone C., Kwok J.B., Bonkowski E.S., Palvadeau R., Tienari P.J., Morrison K.E., Shaw P.J., Al-Chalabi A., Brown R.H., Calvo A., Mora G., Al-Saif H., Gotkine M., Leigh F., Chang I.J., Perlman S.J., Glass I., Scott A.I., Shaw C.E., Basak A.N., Landers J.E., Chio A., Crawford T.O., Smith B.N., Traynor B.J., Fallini C., Gkazi A.S., Scotter E.L., Kenna K.P., Keagle P., Tiloca C., Vance C., Colombrita C., King A., Pensato V., Castellotti B., Baas F., Ten Asbroek A.L.M.A., McKenna-Yasek D., McLaughlin R.L., Polak M., Asress S., Esteban-Perez J., Stevic Z., D'Alfonso S., Mazzini L., Comi G.P., Del Bo R., Ceroni M., Gagliardi S., Querin G., Bertolin C., Van Rheenen W., Rademakers R., Van Blitterswijk M., Lauria G., Duga S., Corti S., Cereda C., Corrado L., Soraru G., Williams K.L., Nicholson G.A., Leblond-Manry C., Rouleau G.A., Hardiman O., Veldink J.H., Van Den Berg L.H., Pall H., Turner M.R., Talbot K., Taroni F., Garcia-Redondo A., Wu Z., Glass J.D., Ratti A., Adeleye A., Soltis A.R., Alba C., Viollet C., Bacikova D., Hupalo D.N., Sukumar G., Pollard H.B., Wilkerson M.D., Martinez E.M., Ahmed S., Arepalli S., Baloh R.H., Bowser R., Brady C.B., Brice A., Broach J., Campbell R.H., Camu W., Cooper-Knock J., Ding J., Drepper C., Drory V.E., Dunckley T.L., Eicher J.D., England B.K., Faghri F., Feldman E., Floeter M.K., Fratta P., Geiger J.T., Gerhard G., Gibson S.B., Hardy J., Harms M.B., Heiman-Patterson T.D., Hernandez D.G., Jansson L., Kirby J., Kowall N.W., Laaksovirta H., Landeck N., Landi F., Le Ber I., Lumbroso S., Macgowan D.J.L., Maragakis N.J., Mouzat K., Murphy N.A., Myllykangas L., Nalls M.A., Orrell R.W., Ostrow L.W., Pamphlett R., Pickering-Brown S., Pioro E.P., Pletnikova O., Pliner H.A., Pulst S.M., Ravits J.M., Rivera A., Robberecht W., Rogaeva E., Rollinson S., Rothstein J.D., Scholz S.W., Sendtner M., Sidle K.C., Simmons Z., Singleton A.B., Smith N., Stone D.J., Troncoso J.C., Valori M., Van Damme P., Van Deerlin V.M., Van Den Bosch L., Zinman L., Angelocola S.M., Ausiello F.P., Barberis M., Bartolomei I., Battistini S., Bersano E., Bisogni G., Borghero G., Brunetti M., Cabona C., Canale F., Canosa A., Cantisani T.A., Capasso M., Caponnetto C., Cardinali P., Carrera P., Casale F., Colletti T., Conforti F.L., Conte A., Conti E., Corbo M., Cuccu S., Dalla Bella E., D'Errico E., Demarco G., Dubbioso R., Ferrarese C., Ferraro P.M., Filippi M., Fini N., Floris G., Fuda G., Gallone S., Gianferrari G., Giannini F., Grassano M., Greco L., Iazzolino B., Introna A., La Bella V., Lattante S., Liguori R., Logroscino G., Logullo F.O., Lunetta C., Mandich P., Mandrioli J., Manera U., Manganelli F., Marangi G., Marinou K., Marrosu M.G., Martinelli I., Messina S., Moglia C., Mosca L., Murru M.R., Origone P., Passaniti C., Petrelli C., Petrucci A., Pozzi S., Pugliatti M., Quattrini A., Ricci C., Riolo G., Riva N., Russo M., Sabatelli M., Salamone P., Salivetto M., Salvi F., Santarelli M., Sbaiz L., Sideri R., Simone I., Simonini C., Spataro R., Tanel R., Tedeschi G., Ticca A., Torriello A., Tranquilli S., Tremolizzo L., Trojsi F., Vasta R., Vacchiano V., Vita G., Volanti P., Zollino M., Zucchi E., Johnson, J. O., Chia, R., Miller, D. E., Li, R., Kumaran, R., Abramzon, Y., Alahmady, N., Renton, A. E., Topp, S. D., Gibbs, J. R., Cookson, M. R., Sabir, M. S., Dalgard, C. L., Troakes, C., Jones, A. R., Shatunov, A., Iacoangeli, A., Al Khleifat, A., Ticozzi, N., Silani, V., Gellera, C., Blair, I. P., Dobson-Stone, C., Kwok, J. B., Bonkowski, E. S., Palvadeau, R., Tienari, P. J., Morrison, K. E., Shaw, P. J., Al-Chalabi, A., Brown, R. H., Calvo, A., Mora, G., Al-Saif, H., Gotkine, M., Leigh, F., Chang, I. J., Perlman, S. J., Glass, I., Scott, A. I., Shaw, C. E., Basak, A. N., Landers, J. E., Chio, A., Crawford, T. O., Smith, B. N., Traynor, B. J., Fallini, C., Gkazi, A. S., Scotter, E. L., Kenna, K. P., Keagle, P., Tiloca, C., Vance, C., Colombrita, C., King, A., Pensato, V., Castellotti, B., Baas, F., Ten Asbroek, A. L. M. A., McKenna-Yasek, D., Mclaughlin, R. L., Polak, M., Asress, S., Esteban-Perez, J., Stevic, Z., D'Alfonso, S., Mazzini, L., Comi, G. P., Del Bo, R., Ceroni, M., Gagliardi, S., Querin, G., Bertolin, C., Van Rheenen, W., Rademakers, R., Van Blitterswijk, M., Lauria, G., Duga, S., Corti, S., Cereda, C., Corrado, L., Soraru, G., Williams, K. L., Nicholson, G. A., Leblond-Manry, C., Rouleau, G. A., Hardiman, O., Veldink, J. H., Van Den Berg, L. H., Pall, H., Turner, M. R., Talbot, K., Taroni, F., Garcia-Redondo, A., Wu, Z., Glass, J. D., Ratti, A., Adeleye, A., Soltis, A. R., Alba, C., Viollet, C., Bacikova, D., Hupalo, D. N., Sukumar, G., Pollard, H. B., Wilkerson, M. D., Martinez, E. M., Ahmed, S., Arepalli, S., Baloh, R. H., Bowser, R., Brady, C. B., Brice, A., Broach, J., Campbell, R. H., Camu, W., Cooper-Knock, J., Ding, J., Drepper, C., Drory, V. E., Dunckley, T. L., Eicher, J. D., England, B. K., Faghri, F., Feldman, E., Floeter, M. K., Fratta, P., Geiger, J. T., Gerhard, G., Gibson, S. B., Hardy, J., Harms, M. B., Heiman-Patterson, T. D., Hernandez, D. G., Jansson, L., Kirby, J., Kowall, N. W., Laaksovirta, H., Landeck, N., Landi, F., Le Ber, I., Lumbroso, S., Macgowan, D. J. L., Maragakis, N. J., Mouzat, K., Murphy, N. A., Myllykangas, L., Nalls, M. A., Orrell, R. W., Ostrow, L. W., Pamphlett, R., Pickering-Brown, S., Pioro, E. P., Pletnikova, O., Pliner, H. A., Pulst, S. M., Ravits, J. M., Rivera, A., Robberecht, W., Rogaeva, E., Rollinson, S., Rothstein, J. D., Scholz, S. W., Sendtner, M., Sidle, K. C., Simmons, Z., Singleton, A. B., Smith, N., Stone, D. J., Troncoso, J. C., Valori, M., Van Damme, P., Van Deerlin, V. M., Van Den Bosch, L., Zinman, L., Angelocola, S. M., Ausiello, F. P., Barberis, M., Bartolomei, I., Battistini, S., Bersano, E., Bisogni, G., Borghero, G., Brunetti, M., Cabona, C., Canale, F., Canosa, A., Cantisani, T. A., Capasso, M., Caponnetto, C., Cardinali, P., Carrera, P., Casale, F., Colletti, T., Conforti, F. L., Conte, A., Conti, E., Corbo, M., Cuccu, S., Dalla Bella, E., D'Errico, E., Demarco, G., Dubbioso, R., Ferrarese, C., Ferraro, P. M., Filippi, M., Fini, N., Floris, G., Fuda, G., Gallone, S., Gianferrari, G., Giannini, F., Grassano, M., Greco, L., Iazzolino, B., Introna, A., La Bella, V., Lattante, S., Liguori, R., Logroscino, G., Logullo, F. O., Lunetta, C., Mandich, P., Mandrioli, J., Manera, U., Manganelli, F., Marangi, G., Marinou, K., Marrosu, M. G., Martinelli, I., Messina, S., Moglia, C., Mosca, L., Murru, M. R., Origone, P., Passaniti, C., Petrelli, C., Petrucci, A., Pozzi, S., Pugliatti, M., Quattrini, A., Ricci, C., Riolo, G., Riva, N., Russo, M., Sabatelli, M., Salamone, P., Salivetto, M., Salvi, F., Santarelli, M., Sbaiz, L., Sideri, R., Simone, I., Simonini, C., Spataro, R., Tanel, R., Tedeschi, G., Ticca, A., Torriello, A., Tranquilli, S., Tremolizzo, L., Trojsi, F., Vasta, R., Vacchiano, V., Vita, G., Volanti, P., Zollino, M., Zucchi, E., Başak, Ayşe Nazlı (ORCID 0000-0001-9257-3540 & YÖK ID 1512), Palvadeau, Robin, Johnson, Janel O., Chia, Ruth, Miller, Danny E., Li, Rachel, Kumaran, Ravindran, Abramzon, Yevgeniya, Alahmady, Nada, Renton, Alan E., Topp, Simon D., Gibbs, J. Raphael, Cookson, Mark R., Sabir, Marya S., Dalgard, Clifton L., Troakes, Claire, Jones, Ashley R., Shatunov, Aleksey, Lacoangeli, Alfredo, Al Khleifat, Ahmad, Ticozzi, Nicola, Silani, Vincenzo, Gellera, Cinzia, Blair, Ian P., Dobson-Stone, Carol, Kwok, John B., Bonkowski, Emily S., Tienari, Pentti J., Morrison, Karen E., Shaw, Pamela J., Al-Chalabi, Ammar, Jr, Robert H. Brown, Calvo, Andrea, Mora, Gabriele, Al-Saif, Hind, Gotkine, Marc, Leigh, Fawn, Chang, Irene J., Perlman, Seth J., Glass, Ian, Scott, Anna, I., Landers, John E., Chio, Adriano, Crawford, Thomas O., Smith, Bradley N., Traynor, Bryan J., Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, Johnson, J, Chia, R, Miller, D, Li, R, Kumaran, R, Abramzon, Y, Alahmady, N, Renton, A, Topp, S, Gibbs, J, Cookson, M, Sabir, M, Dalgard, C, Troakes, C, Jones, A, Shatunov, A, Iacoangeli, A, Al Khleifat, A, Ticozzi, N, Silani, V, Gellera, C, Blair, I, Dobson-Stone, C, Kwok, J, Bonkowski, E, Palvadeau, R, Tienari, P, Morrison, K, Shaw, P, Al-Chalabi, A, Brown, R, Calvo, A, Mora, G, Al-Saif, H, Gotkine, M, Leigh, F, Chang, I, Perlman, S, Glass, I, Scott, A, Shaw, C, Basak, A, Landers, J, Chiò, A, Crawford, T, Smith, B, Traynor, B, Fallini, C, Gkazi, A, Scotter, E, Kenna, K, Keagle, P, Tiloca, C, Vance, C, Colombrita, C, King, A, Pensato, V, Castellotti, B, Baas, F, Ten Asbroek, A, McKenna-Yasek, D, Mclaughlin, R, Polak, M, Asress, S, Esteban-Pérez, J, Stevic, Z, D'Alfonso, S, Mazzini, L, Comi, G, Del Bo, R, Ceroni, M, Gagliardi, S, Querin, G, Bertolin, C, van Rheenen, W, Rademakers, R, van Blitterswijk, M, Lauria, G, Duga, S, Corti, S, Cereda, C, Corrado, L, Sorarù, G, Williams, K, Nicholson, G, Leblond-Manry, C, Rouleau, G, Hardiman, O, Veldink, J, van den Berg, L, Pall, H, Turner, M, Talbot, K, Taroni, F, García-Redondo, A, Wu, Z, Glass, J, Ratti, A, Adeleye, A, Soltis, A, Alba, C, Viollet, C, Bacikova, D, Hupalo, D, Sukumar, G, Pollard, H, Wilkerson, M, Martinez, E, Ahmed, S, Arepalli, S, Baloh, R, Bowser, R, Brady, C, Brice, A, Broach, J, Campbell, R, Camu, W, Cooper-Knock, J, Ding, J, Drepper, C, Drory, V, Dunckley, T, Eicher, J, England, B, Faghri, F, Feldman, E, Floeter, M, Fratta, P, Geiger, J, Gerhard, G, Gibson, S, Hardy, J, Harms, M, Heiman-Patterson, T, Hernandez, D, Jansson, L, Kirby, J, Kowall, N, Laaksovirta, H, Landeck, N, Landi, F, Le Ber, I, Lumbroso, S, Macgowan, D, Maragakis, N, Mouzat, K, Murphy, N, Myllykangas, L, Nalls, M, Orrell, R, Ostrow, L, Pamphlett, R, Pickering-Brown, S, Pioro, E, Pletnikova, O, Pliner, H, Pulst, S, Ravits, J, Rivera, A, Robberecht, W, Rogaeva, E, Rollinson, S, Rothstein, J, Scholz, S, Sendtner, M, Sidle, K, Simmons, Z, Singleton, A, Smith, N, Stone, D, Troncoso, J, Valori, M, Van Damme, P, Van Deerlin, V, Van Den Bosch, L, Zinman, L, Angelocola, S, Ausiello, F, Barberis, M, Bartolomei, I, Battistini, S, Bersano, E, Bisogni, G, Borghero, G, Brunetti, M, Cabona, C, Canale, F, Canosa, A, Cantisani, T, Capasso, M, Caponnetto, C, Cardinali, P, Carrera, P, Casale, F, Colletti, T, Conforti, F, Conte, A, Conti, E, Corbo, M, Cuccu, S, Dalla Bella, E, D'Errico, E, Demarco, G, Dubbioso, R, Ferrarese, C, Ferraro, P, Filippi, M, Fini, N, Floris, G, Fuda, G, Gallone, S, Gianferrari, G, Giannini, F, Grassano, M, Greco, L, Iazzolino, B, Introna, A, La Bella, V, Lattante, S, Liguori, R, Logroscino, G, Logullo, F, Lunetta, C, Mandich, P, Mandrioli, J, Manera, U, Manganelli, F, Marangi, G, Marinou, K, Marrosu, M, Martinelli, I, Messina, S, Moglia, C, Mosca, L, Murru, M, Origone, P, Passaniti, C, Petrelli, C, Petrucci, A, Pozzi, S, Pugliatti, M, Quattrini, A, Ricci, C, Riolo, G, Riva, N, Russo, M, Sabatelli, M, Salamone, P, Salivetto, M, Salvi, F, Santarelli, M, Sbaiz, L, Sideri, R, Simone, I, Simonini, C, Spataro, R, Tanel, R, Tedeschi, G, Ticca, A, Torriello, A, Tranquilli, S, Tremolizzo, L, Trojsi, F, Vasta, R, Vacchiano, V, Vita, G, Volanti, P, Zollino, M, Zucchi, E, HUS Neurocenter, Department of Neurosciences, Clinicum, Neurologian yksikkö, TRIMM - Translational Immunology Research Program, Pentti Tienari / Principal Investigator, Human Genetics, ARD - Amsterdam Reproduction and Development, ANS - Complex Trait Genetics, Johnson, Janel O, Miller, Danny E, Renton, Alan E, Topp, Simon D, Gibbs, J Raphael, Cookson, Mark R, Sabir, Marya S, Dalgard, Clifton L, Jones, Ashley R, Iacoangeli, Alfredo, Blair, Ian P, Kwok, John B, Bonkowski, Emily S, Tienari, Pentti J, Morrison, Karen E, Shaw, Pamela J, Brown, Robert H, Chang, Irene J, Perlman, Seth J, Scott, Anna I, Shaw, Christopher E, Basak, A Nazli, Landers, John E, Chiò, Adriano, Crawford, Thomas O, Smith, Bradley N, Traynor, Bryan J, Fallini, Claudia, Gkazi, Athina Soragia, Scotter, Emma L, Kenna, Kevin P, Keagle, Pamela, Tiloca, Cinzia, Vance, Caroline, Colombrita, Claudia, King, Andrew, Pensato, Viviana, Castellotti, Barbara, Baas, Frank, Ten Asbroek, Anneloor L M A, McKenna-Yasek, Diane, Mclaughlin, Russell L, Polak, Meraida, Asress, Seneshaw, Esteban-Pérez, Jesú, Stevic, Zorica, D'Alfonso, Sandra, Mazzini, Letizia, Comi, Giacomo P, Del Bo, Roberto, Ceroni, Mauro, Gagliardi, Stella, Querin, Giorgia, Bertolin, Cinzia, van Rheenen, Wouter, Rademakers, Rosa, van Blitterswijk, Marka, Lauria, Giuseppe, Duga, Stefano, Corti, Stefania, Cereda, Cristina, Corrado, Lucia, Sorarù, Gianni, Williams, Kelly L, Nicholson, Garth A, Leblond-Manry, Claire, Rouleau, Guy A, Hardiman, Orla, Veldink, Jan H, van den Berg, Leonard H, Pall, Hardev, Turner, Martin R, Talbot, Kevin, Taroni, Franco, García-Redondo, Alberto, Wu, Zheyang, Glass, Jonathan D, Ratti, Antonia, Adeleye, Adelani, Soltis, Anthony R, Alba, Camille, Viollet, Coralie, Bacikova, Dagmar, Hupalo, Daniel N, Sukumar, Gauthaman, Pollard, Harvey B, Wilkerson, Matthew D, Martinez, Elisa McGrath, Ahmed, Sarah, Arepalli, Sampath, Baloh, Robert H, Bowser, Robert, Brady, Christopher B, Brice, Alexi, Broach, Jame, Campbell, Roy H, Camu, William, Cooper-Knock, John, Ding, Jinhui, Drepper, Carsten, Drory, Vivian E, Dunckley, Travis L, Eicher, John D, England, Bryce K, Faghri, Faraz, Feldman, Eva, Floeter, Mary Kay, Fratta, Pietro, Geiger, Joshua T, Gerhard, Glenn, Gibson, Summer B, Hardy, John, Harms, Matthew B, Heiman-Patterson, Terry D, Hernandez, Dena G, Jansson, Lilja, Kirby, Janine, Kowall, Neil W, Laaksovirta, Hannu, Landeck, Natalie, Landi, Francesco, Le Ber, Isabelle, Lumbroso, Serge, Macgowan, Daniel J L, Maragakis, Nicholas J, Mouzat, Kevin, Murphy, Natalie A, Myllykangas, Liisa, Nalls, Mike A, Orrell, Richard W, Ostrow, Lyle W, Pamphlett, Roger, Pickering-Brown, Stuart, Pioro, Erik P, Pletnikova, Olga, Pliner, Hannah A, Pulst, Stefan M, Ravits, John M, Rivera, Alberto, Robberecht, Wim, Rogaeva, Ekaterina, Rollinson, Sara, Rothstein, Jeffrey D, Scholz, Sonja W, Sendtner, Michael, Sidle, Katie C, Simmons, Zachary, Singleton, Andrew B, Smith, Nathan, Stone, David J, Troncoso, Juan C, Valori, Miko, Van Damme, Philip, Van Deerlin, Vivianna M, Van Den Bosch, Ludo, Zinman, Lorne, Angelocola, Stefania M, Ausiello, Francesco P, Barberis, Marco, Bartolomei, Ilaria, Battistini, Stefania, Bersano, Enrica, Bisogni, Giulia, Borghero, Giuseppe, Brunetti, Maura, Cabona, Corrado, Canale, Fabrizio, Canosa, Antonio, Cantisani, Teresa A, Capasso, Margherita, Caponnetto, Claudia, Cardinali, Patrizio, Carrera, Paola, Casale, Federico, Colletti, Tiziana, Conforti, Francesca L, Conte, Amelia, Conti, Elisa, Corbo, Massimo, Cuccu, Stefania, Dalla Bella, Eleonora, D'Errico, Eustachio, Demarco, Giovanni, Dubbioso, Raffaele, Ferrarese, Carlo, Ferraro, Pilar M, Filippi, Massimo, Fini, Nicola, Floris, Gianluca, Fuda, Giuseppe, Gallone, Salvatore, Gianferrari, Giulia, Giannini, Fabio, Grassano, Maurizio, Greco, Lucia, Iazzolino, Barbara, Introna, Alessandro, La Bella, Vincenzo, Lattante, Serena, Liguori, Rocco, Logroscino, Giancarlo, Logullo, Francesco O, Lunetta, Christian, Mandich, Paola, Mandrioli, Jessica, Manera, Umberto, Manganelli, Fiore, Marangi, Giuseppe, Marinou, Kalliopi, Marrosu, Maria Giovanna, Martinelli, Ilaria, Messina, Sonia, Moglia, Cristina, Mosca, Lorena, Murru, Maria R, Origone, Paola, Passaniti, Carla, Petrelli, Cristina, Petrucci, Antonio, Pozzi, Susanna, Pugliatti, Maura, Quattrini, Angelo, Ricci, Claudia, Riolo, Giulia, Riva, Nilo, Russo, Massimo, Sabatelli, Mario, Salamone, Paolina, Salivetto, Marco, Salvi, Fabrizio, Santarelli, Marialuisa, Sbaiz, Luca, Sideri, Riccardo, Simone, Isabella, Simonini, Cecilia, Spataro, Rossella, Tanel, Raffaella, Tedeschi, Gioacchino, Ticca, Anna, Torriello, Antonella, Tranquilli, Stefania, Tremolizzo, Lucio, Trojsi, Francesca, Vasta, Rosario, Vacchiano, Veria, Vita, Giuseppe, Volanti, Paolo, Zollino, Marcella, and Zucchi, Elisabetta
Subjects: Hereditary sensory neuropathy, L-serine, Mutations, Deoxysphingolipids, Accumulation, Enzyme complex, Juvenile amyotrophic lateral sclerosis, Serine C-Palmitoyltransferase, Whole Exome Sequencing, 0302 clinical medicine, Medicine, Family history, Amyotrophic lateral sclerosis, Child, Index case, Exome sequencing, Original Investigation, 0303 health sciences, Neurosciences and neurology, 3. Good health, Child, Preschool, Failure to thrive, Female, medicine.symptom, Life Sciences & Biomedicine, L-SERINE, Comments, Human, Adult, medicine.medical_specialty, Adolescent, Amyotrophic Lateral Sclerosis, Genetic Predisposition to Disease, Humans, Mutation, Young Adult, Clinical Neurology, NO, 03 medical and health sciences, DEOXYSPHINGOLIPIDS, Internal medicine, Exome Sequencing, Online First, Juvenile, Preschool, 030304 developmental biology, ACCUMULATION, Science & Technology, SPTLC1, business.industry, MUTATIONS, Research, 3112 Neurosciences, medicine.disease, HEREDITARY SENSORY NEUROPATHY, juvenile, 3111 Biomedicine, Neurology (clinical), Neurosciences & Neurology, ALS, genetic, business, 030217 neurology & neurosurgery, Amyotrophic Lateral Sclerosi
Abstract: Key Points Question What genetic variants are associated with juvenile amyotrophic lateral sclerosis (ALS)? Findings In this family-based genetic study, exome sequencing was performed in 3 patients diagnosed with juvenile ALS and failure to thrive; this identified de novo variants in SPTLC1 (p.Ala20Ser in 2 patients and p.Ser331Tyr in 1 patient). Variants in SPTLC1 are a known cause of hereditary sensory and autonomic neuropathy, type 1A, and these data extend the phenotype associated with this gene. Meaning De novo variants in the SPTLC1 gene are associated with juvenile ALS, a fatal neurological disorder., This genetic association study identifies genetic variants associated with juvenile amyotrophic lateral sclerosis., Importance Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized by age of symptom onset less than 25 years and a variable presentation. Objective To identify the genetic variants associated with juvenile ALS. Design, Setting, and Participants In this multicenter family-based genetic study, trio whole-exome sequencing was performed to identify the disease-associated gene in a case series of unrelated patients diagnosed with juvenile ALS and severe growth retardation. The patients and their family members were enrolled at academic hospitals and a government research facility between March 1, 2016, and March 13, 2020, and were observed until October 1, 2020. Whole-exome sequencing was also performed in a series of patients with juvenile ALS. A total of 66 patients with juvenile ALS and 6258 adult patients with ALS participated in the study. Patients were selected for the study based on their diagnosis, and all eligible participants were enrolled in the study. None of the participants had a family history of neurological disorders, suggesting de novo variants as the underlying genetic mechanism. Main Outcomes and Measures De novo variants present only in the index case and not in unaffected family members. Results Trio whole-exome sequencing was performed in 3 patients diagnosed with juvenile ALS and their parents. An additional 63 patients with juvenile ALS and 6258 adult patients with ALS were subsequently screened for variants in the SPTLC1 gene. De novo variants in SPTLC1 (p.Ala20Ser in 2 patients and p.Ser331Tyr in 1 patient) were identified in 3 unrelated patients diagnosed with juvenile ALS and failure to thrive. A fourth variant (p.Leu39del) was identified in a patient with juvenile ALS where parental DNA was unavailable. Variants in this gene have been previously shown to be associated with autosomal-dominant hereditary sensory autonomic neuropathy, type 1A, by disrupting an essential enzyme complex in the sphingolipid synthesis pathway. Conclusions and Relevance These data broaden the phenotype associated with SPTLC1 and suggest that patients presenting with juvenile ALS should be screened for variants in this gene.
Published: 2021
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45. Open data from the first and second observing runs of advanced LIGO and advanced Virgo

Author: Rich&nbsp, Abbott, Thomas&nbsp, Sheelu&nbsp, Abraham, Fausto&nbsp, Acernese, Kendall&nbsp, Ackley, Carl&nbsp, Adams, Rana&nbsp, Adhikari, Vaishali&nbsp, Adya, Christoph&nbsp, Affeldt, Michalis&nbsp, Agathos, Kazuhiro&nbsp, Agatsuma, Nancy&nbsp, Aggarwal, Odylio&nbsp, Aguiar, Amit&nbsp, Aich, Lorenzo&nbsp, Aiello, Anirban&nbsp, Ain, Ajith&nbsp, Parameswaran, Gabrielle&nbsp, Allen, Annalisa&nbsp, Allocca, Paul&nbsp, Altin, Alex&nbsp, Amato, Shreya&nbsp, Anand, Alena&nbsp, Ananyeva, Stuart&nbsp, Anderson, Warren&nbsp, Svetoslava, Angelova, Stefano&nbsp, Ansoldi, Sarah&nbsp, Antier, Stephen&nbsp, Appert, Koji&nbsp, Arai, Melody, Araya, Joseph, Areeda, Marc&nbsp, Arène, Nicolas&nbsp, Arnaud, Scott, Aronson, Arun, Kg, Ascenzi, Gregory&nbsp, Ashton, Stuart, Aston, Pia&nbsp, Astone, Florian&nbsp, Aubin, Peter&nbsp, Aufmuth, Kellie&nbsp, Aultoneal, Corey&nbsp, Austin, Valerie&nbsp, Avendano, Stanislav&nbsp, Babak, Philippe&nbsp, Bacon, Francesca&nbsp, Badaracco, Maria, Bader, Sangwook&nbsp, Bae, Anne, Baer, Jonathon&nbsp, Baird, Baldaccini, Giulio&nbsp, Ballardin, Stefan, Ballmer, Anna-marie&nbsp, Bals, Alexander&nbsp, Balsamo, Baltus, Sharan&nbsp, Banagiri, Deepak&nbsp, Bankar, Rameshwar, Bankar, Juan, Barayoga, Claudio&nbsp, Barbieri, Barry, Barish, David&nbsp, Barker, Kevin&nbsp, Barkett, Pablo&nbsp, Barneo, Fabrizio&nbsp, Barone, Bryan&nbsp, Barr, Lisa&nbsp, Barsotti, Matteo&nbsp, Barsuglia, Daniel&nbsp, Barta, Jeffrey&nbsp, Bartlett, Imre&nbsp, Bartos, Riccardo&nbsp, Bassiri, Andrea&nbsp, Basti, Mateusz&nbsp, Bawaj, Joseph, Bayley, Marco&nbsp, Bazzan, Bence&nbsp, Bécsy, Michal&nbsp, Bejger, Imene&nbsp, Belahcene, Angus, Bell, Deeksha&nbsp, Beniwal, Michael, Benjamin, Joe, Bentley, Fabio&nbsp, Bergamin, Beverly, Berger, Gerald&nbsp, Bergmann, Sebastiano&nbsp, Bernuzzi, Christopher, Berry, Diego&nbsp, Bersanetti, Alessandro&nbsp, Bertolini, Joseph&nbsp, Betzwieser, Rohan&nbsp, Bhandare, Ankit, Bhandari, Bidler, Edward&nbsp, Biggs, Igor, Bilenko, Garilynn&nbsp, Billingsley, Ross&nbsp, Birney, Ofek&nbsp, Birnholtz, Sebastien&nbsp, Biscans, Bischi, Sylvia&nbsp, Biscoveanu, Aparna&nbsp, Bisht, Guldauren&nbsp, Bissenbayeva, Massimiliano&nbsp, Bitossi, Marieanne, Bizouard, Kent, Blackburn, Jonathan&nbsp, Blackman, Carl, Blair, David, Blair, Ryan, Blair, Bobba, Nina&nbsp, Bode, Michel&nbsp, Boer, Yannick&nbsp, Boetzel, Gilles&nbsp, Bogaert, Francois&nbsp, Bondu, Edgard&nbsp, Bonilla, Romain&nbsp, Bonnand, Phillip&nbsp, Booker, Boris, Boom, Rolf&nbsp, Bork, Valerio&nbsp, Boschi, Sukanta&nbsp, Bose, Vladimir&nbsp, Bossilkov, Joel&nbsp, Bosveld, Yann&nbsp, Bouffanais, Antonella&nbsp, Bozzi, Carlo&nbsp, Bradaschia, Patrick, Brady, Alyssa&nbsp, Bramley, Marica&nbsp, Branchesi, Jim, Brau, Breschi, Tristan&nbsp, Briant, Joseph, Briggs, Francesco&nbsp, Brighenti, Alain&nbsp, Brillet, Brinkmann, Patrick&nbsp, Brockill, Aidan, Brooks, Brooks, Daniel, Brown, Sharon&nbsp, Brunett, Giacomo&nbsp, Bruno, Robert&nbsp, Bruntz, Aaron&nbsp, Buikema, Tomasz&nbsp, Bulik, Henk, Bulten, Alessandra&nbsp, Buonanno, Damir&nbsp, Buskulic, Robert, Byer, Miriam&nbsp, Cabero, Laura&nbsp, Cadonati, Giampietro&nbsp, Cagnoli, Craig&nbsp, Cahillane, Juan&nbsp, Calderón&nbsp, Bustillo, Jack, Callaghan, Thomas, Callister, Enrico&nbsp, Calloni, Jordan, Camp, Maurizio&nbsp, Canepa, Kipp, Cannon, Huy-tuong&nbsp, Cao, Junwei&nbsp, Giovanni&nbsp, Carapella, Franco&nbsp, Carbognani, Santiago&nbsp, Caride, Matthew, Carney, Gregorio&nbsp, Carullo, Julia&nbsp, Casanueva&nbsp, Diaz, Claudio&nbsp, Casentini, Javier&nbsp, Castañeda, Sarah&nbsp, Caudill, Marco&nbsp, Cavaglià, Fabien&nbsp, Cavalier, Roberto&nbsp, Cavalieri, Giancarlo&nbsp, Cella, Pablo&nbsp, Cerdá-Durán, Elisabetta&nbsp, Cesarini, Oualid&nbsp, Chaibi, Kabir&nbsp, Chakravarti, Chiwai&nbsp, Chan, Manleong&nbsp, Chan, Shiuh&nbsp, Chao, Philip&nbsp, Charlton, Eve, Chase, Eric&nbsp, Chassande-Mottin, Deep&nbsp, Chatterjee, Mayank&nbsp, Chaturvedi, Hsin-yu, Chen, Xu&nbsp, Chen, Yanbei&nbsp, Hai-ping&nbsp, Cheng, Chi-kit, Cheong, Hanyu, Chia, Chiadini, Roberto&nbsp, Chierici, Chincarini, Antonino&nbsp, Chiummo, Gihyuk&nbsp, Cho, Heesuk, Cho, Min-a&nbsp, Nelson&nbsp, Christensen, Qi&nbsp, Chu, Sheon&nbsp, Chua, Ka-wai, Chung, Shinkee&nbsp, Chung, Ciani, Pawel&nbsp, Ciecielag, Marek&nbsp, Cieślar, Alexei, Ciobanu, Ciolfi, Cipriano, Alessio&nbsp, Cirone, Filiberto&nbsp, Clara, James, Clark, Clearwater, Clesse, Frederic&nbsp, Cleva, Eugenio&nbsp, Coccia, Pierre-francois&nbsp, Cohadon, Cohen, Marta&nbsp, Colleoni, Christophe, Collette, Christopher&nbsp, Collins, Monica&nbsp, Colpi, Marcio&nbsp, Constancio&nbsp, Livia&nbsp, Jr., Conti, Sam, Cooper, Corban, Thomas, Corbitt, Isabel&nbsp, Cordero-Carrión, Silvia&nbsp, Corezzi, Kenneth, Corley, Neil&nbsp, Cornish, Corre, Corsi, Cortese, Cesar, Costa, Cotesta, Michael, Coughlin, Scott, Coughlin, Jeanpierre&nbsp, Coulon, Stefan, Countryman, Couvares, Pep, Covas, David, Coward, Matthew, Cowart, Dennis, Coyne, Coyne, Jolien, &nbsp, Creighton, Teviet, Creighton, Cripe, Michael&nbsp, Croquette, Sgwynne, Crowder, Jean-rene&nbsp, Cudell, Torrey, Cullen, Alan&nbsp, Cumming, Rebecca&nbsp, Cummings, Liam&nbsp, Cunningham, Elena&nbsp, Cuoco, Malgorzata&nbsp, Curylo, Tito&nbsp, Dal&nbsp, Canton, Gergely&nbsp, Dálya, Aykutlu&nbsp, Dana, Lara, Daneshgaran-Bajastani, Beatrice&nbsp, D’Angelo, Stefan, Danilishin, Sabrina&nbsp, D’Antonio, Karsten&nbsp, Danzmann, Christian&nbsp, Darsow-Fromm, Arnab&nbsp, Dasgupta, Laurence, &nbsp, Datrier, Vincenzo&nbsp, Dattilo, Ishant&nbsp, Dave, Michel&nbsp, Davier, Gareth, Davies, Derek&nbsp, Davis, Edward, Daw, Dan&nbsp, Debra, Malathi&nbsp, Deenadayalan, Jerome&nbsp, Degallaix, Martina&nbsp, De&nbsp, Laurentis, Samuel&nbsp, Deléglise, Matthew&nbsp, Delfavero, Nicola&nbsp, Lillo, Walter&nbsp, Del&nbsp, Pozzo, Lindsay, Demarchi, Virginia&nbsp, D’Emilio, Nicholas&nbsp, Demos, Dent, Pietri, Rosario&nbsp, Rosa, Camilla&nbsp, Rossi, Riccardo&nbsp, Desalvo, Omar&nbsp, de&nbsp, Varona, Sanjeev&nbsp, Dhurandhar, Mario, Díaz, Mauricio&nbsp, Diaz-Ortiz&nbsp, Tim&nbsp, Dietrich, Luciano&nbsp, Di&nbsp, Fiore, Chiara&nbsp, Fronzo, Cinzia&nbsp, Giorgio, Giovanni, Matteo&nbsp, Giovanni, Tristano&nbsp, Girolamo, Alberto&nbsp, Lieto, Binlei&nbsp, Ding, Sibilla&nbsp, Pace, Irene&nbsp, Palma, Renzo, Atul, Divakarla, Artemiy&nbsp, Dmitriev, Zoheyr&nbsp, Doctor, Fred&nbsp, Donovan, Katherine, Dooley, Suresh&nbsp, Doravari, Iain&nbsp, Dorrington, Thomas, Downes, Drago, Jenne, Driggers, Zhihui&nbsp, Jean-gregoire&nbsp, Ducoin, Dupej, Ofelia&nbsp, Durante, Domenico&nbsp, D’Urso, Sheila, Dwyer, Paul, Easter, Graeme&nbsp, Eddolls, Bruce&nbsp, Edelman, Tega, Edo, Oliver&nbsp, Edy, Anamaria&nbsp, Effler, Phil&nbsp, Ehrens, Johannes&nbsp, Eichholz, Stephen, Eikenberry, Eisenmann, Robert, Eisenstein, Aldo&nbsp, Ejlli, Lucianolucianikerrico&nbsp, Errico, Reed, Essick, Hector&nbsp, Estelles, Dimitri&nbsp, Estevez, Zachariah, Etienne, Todd&nbsp, Etzel, Matthew&nbsp, Evans, Tom, Evans, Rebecca, Ewing, Viviana&nbsp, Fafone, Fairhurst, Xilong&nbsp, Fan, Stefania&nbsp, Farinon, Benjamin&nbsp, Farr, Will, Farr, Edward, Fauchon-Jones, Favata, Maxime&nbsp, Fays, Mariana&nbsp, Fazio, Jon&nbsp, Feicht, Martin, Fejer, Fangchen&nbsp, Feng, Edit&nbsp, Fenyvesi, Deborah, Ferguson, Alvaro&nbsp, Fernandez-Galiana, Isidoro&nbsp, Ferrante, Elvis, Ferreira, Tabata, Ferreira, Fidecaro, Irene&nbsp, Fiori, Donatella&nbsp, Fiorucci, Maya&nbsp, Fishbach, Ryan, Fisher, Rosalba&nbsp, Fittipaldi, Margot&nbsp, Fitz-Axen, Vincenzo&nbsp, Fiumara, Raffaele&nbsp, Flaminio, Erik&nbsp, Floden, Flynn, Heather&nbsp, Fong, Antonio, Font, Perry&nbsp, Forsyth, Jean-daniel&nbsp, Fournier, Sergio&nbsp, Frasca, Frasconi, Zsolt&nbsp, Frei, Andreas&nbsp, Freise, Raymond&nbsp, Frey, Valentin&nbsp, Fritschel, Valery, Frolov, Gabriele&nbsp, Fronzè, Fulda, Fyffe, Hunter, Gabbard, Bhooshan, Gadre, Sebastian, Gaebel, Jonathan, Gair, Shanika&nbsp, Galaudage, Dhruva&nbsp, Ganapathy, Sharad, Gaonkar, Cecilio&nbsp, García-Quirós, Garufi, Bubba&nbsp, Gateley, Gaudio, Gayathri&nbsp, Gayathri, Gianluca&nbsp, Gemme, Genin, Alberto&nbsp, Gennai, George, Jogy&nbsp, Laszlo&nbsp, Gergely, Sudarshan&nbsp, Ghonge, Abhirup&nbsp, Ghosh, Archisman&nbsp, Shaon&nbsp, Bruno&nbsp, Giacomazzo, Joe, Giaime, Dwayne, Giardina, Des, Gibson, Chalisa&nbsp, Gier, Kiranjyot&nbsp, Gill, Jane&nbsp, Glanzer, Jan&nbsp, Gniesmer, Godwin, Evan&nbsp, Goetz, Ryan&nbsp, Niklas&nbsp, Gohlke, Boris&nbsp, Goncharov, Gabriela&nbsp, González, Gopakumar&nbsp, Gopakumar, Sarah, Gossan, Matthieu&nbsp, Gosselin, Gouaty, Grace, Aniello&nbsp, Grado, Massimo&nbsp, Granata, Alastair&nbsp, Grant, Slawomir&nbsp, Gras, Grassia, Gray, Rachel&nbsp, Giuseppe&nbsp, Greco, Anna, Green, Rhys&nbsp, Green, Elizabeth, Gretarsson, Hannah, Griggs, nbsp, Grignani, Grimaldi, Stefan, Grimm, Hartmut&nbsp, Grote, Steffen&nbsp, Grunewald, Pierre&nbsp, Gruning, Gianluca, Guidi, Andre, Guimaraes, Gerard&nbsp, Guixé, Hitesh, Gulati, Yuefan&nbsp, Guo, Anuradha&nbsp, Gupta, Anchal&nbsp, Pawan&nbsp, Eric, Gustafson, Dick&nbsp, Gustafson, Leila&nbsp, Haegel, Odysse&nbsp, Halim, Evan, Hall, Eleanor, Hamilton, Giles&nbsp, Hammond, Maria&nbsp, Haney, Manuela, Hanke, Hanks, Chad&nbsp, Hanna, Mark, Hannam, Otto, Hannuksela, Travis, Hansen, Joe&nbsp, Hanson, Harder, Terra&nbsp, Hardwick, Haris&nbsp, Haris, Harms, Gregg, Harry, Ian, Harry, Raine, Hasskew, Carl-johan&nbsp, Haster, Karen&nbsp, Haughian, Fergus, Hayes, James&nbsp, Healy, Antoine&nbsp, Heidmann, Matthew, Heintze, Joscha&nbsp, Heinze, Henrich&nbsp, Heitmann, Frances&nbsp, Hellman, Patrice&nbsp, Hello, Gary&nbsp, Hemming, Martin&nbsp, Hendry, Siong, Heng, Hennes, Jan-simon&nbsp, Hennig, Michele&nbsp, Heurs, Stefan&nbsp, Hild, Tanja&nbsp, Hinderer, Sarah, Hoback, Sven&nbsp, Hochheim, Elyssa&nbsp, Hofgard, Hofman, Aaron, Holgado, Nathan, Holland, Kathy&nbsp, Holt, Daniel, Holz, Hopkins, Horst, Hough, Eric, Howell, Charlie, Hoy, Yiwen&nbsp, Huang, Moritz, Hübner, Eliu, Huerta, Dominique&nbsp, Huet, Brennan&nbsp, Hughey, Victor&nbsp, Hui, Sascha&nbsp, Husa, Sabina, Huttner, Rachael&nbsp, Huxford, Tien&nbsp, Huynh-Dinh, Bartosz&nbsp, Idzkowski, Iess, Henri&nbsp, Inchauspe, Ingram, Intini, Jean, Isac, Max&nbsp, Isi, Bala, Iyer, Thibaut&nbsp, Jacqmin, Sameer, Jadhav, Shreejit, Jadhav, Alasdair, James, Karan&nbsp, Jani, Nagaraj, Janthalur, Piotr&nbsp, Jaranowski, Jariwala, Rafel&nbsp, Jaume, Alex, Jenkins, Jun&nbsp, Jiang, Grace, Johns, Aaron, Jones, Ian, Jones, Jeff, Jones, Philip&nbsp, Jones, Russell&nbsp, Reinier, &nbsp, Jonker, Ju&nbsp, Jonas&nbsp, Junker, Chinmay, Kalaghatgi, Vassiliki&nbsp, Kalogera, Brittany&nbsp, Kamai, Shivaraj&nbsp, Kandhasamy, Gungwon&nbsp, Kang, Jonah, Kanner, Shasvath, Kapadia, Karki, Rahul&nbsp, Kashyap, Marie&nbsp, Kasprzack, Wolfgang&nbsp, Kastaun, Stavros&nbsp, Katsanevas, Katsavounidis, William&nbsp, Katzman, Kaufer, Keita&nbsp, Kawabe, Fabien&nbsp, Kéfélian, Keitel, Azadeh&nbsp, Keivani, Kennedy, Joey, Key, Sudiksha&nbsp, Khadka, Farit, Khalili, Imran&nbsp, Khan, Sebastian&nbsp, Zaki, Khan, Efim, Khazanov, Nandita&nbsp, Khetan, Mohammad&nbsp, Khursheed, Nutsinee&nbsp, Kijbunchoo, Chunglee&nbsp, Kim, Grace, Kim, Jeongcho, Kim, Kyungmin&nbsp, Won&nbsp, Whansun, Kim, Young-min&nbsp, Charles&nbsp, Kimball, Peter, King, Kinley-Hanlon, Robin&nbsp, Kirchhoff, Jeffrey, Kissel, Kleybolte, Sergei&nbsp, Klimenko, Tyler, Knowles, Koch, Sina, Koehlenbeck, Gideon&nbsp, Koekoek, Soumen&nbsp, Koley, Veronica&nbsp, Kondrashov, Antonios&nbsp, Kontos, Nico&nbsp, Koper, Mikhail&nbsp, Korobko, William, Korth, Manoj&nbsp, Kovalam, Dan, Kozak, Volker&nbsp, Kringel, Krishnendu, Nv, Andrzej&nbsp, Królak, Natalie&nbsp, Krupinski, Gerrit&nbsp, Kuehn, Anil&nbsp, Kumar, Prayush&nbsp, Rakesh&nbsp, Sumit&nbsp, Ling-chi&nbsp, Kuo, Adam&nbsp, Kutynia, Benjamin, Lackey, Danny&nbsp, Laghi, Emile&nbsp, Lalande, Lam, Lam, Astrid&nbsp, Lamberts, Landry, Benjamin, Lane, Ryan, Lang, Jacob&nbsp, Lange, Brian&nbsp, Lantz, Robert, Lanza, Iuri&nbsp, La&nbsp, Rosa, Angelique&nbsp, Lartaux-Vollard, Paul, Lasky, Laxen, Albert&nbsp, Lazzarini, Claudia&nbsp, Lazzaro, Paola&nbsp, Leaci, Sean&nbsp, Leavey, Yannick, Lecoeuche, Chang-hwan, Lee, Hyung-mok, Lee, Hyungwon, Lee, Joongoo&nbsp, Lee, Kyung-ha&nbsp, Lehmann, Leroy, Letendre, Yuri&nbsp, Levin, Alvin, &nbsp, Jin&nbsp, Kaye&nbsp, Tjonnie, &nbsp, Xiang&nbsp, Frank&nbsp, Linde, Seth, Linker, Jethro, Linley, Tyson, Littenberg, Liu&nbsp, Liu, Xiaoshu&nbsp, Miquel&nbsp, Llorens-Monteagudo, Ka-lok&nbsp, Alexandra&nbsp, Lockwood, Lionel, London, Longo, Lorenzini, Vincent&nbsp, Loriette, Lormand, Losurdo, James, Lough, Carlos, Lousto, Geoffrey&nbsp, Lovelace, Harald&nbsp, Lück, Diana&nbsp, Lumaca, Andrew, Lundgren, Ma&nbsp, Yiqiu, Ronaldas&nbsp, Macas, Macfoy, Myron&nbsp, Macinnis, Duncan, Macleod, Ian, Macmillan, Adrian&nbsp, Macquet, Ignacio&nbsp, Magaña&nbsp, Hernandez, Fabian&nbsp, Magaña-Sandoval, Ryan, Magee, Ettore&nbsp, Majorana, Ivan&nbsp, Maksimovic, Asmita&nbsp, Malik, Catherine&nbsp, Man, Vuk&nbsp, Mandic, Valentina&nbsp, Mangano, Georgia, Mansell, Manske, Maddalena&nbsp, Mantovani, Michela&nbsp, Mapelli, Marchesoni, Frederique&nbsp, Marion, Szabolcs&nbsp, Márka, Zsuzsanna&nbsp, Charalampos&nbsp, Markakis, Ashot, Markosyan, Markowitz, Ed&nbsp, Maros, Antonio&nbsp, Marquina, Sylvain&nbsp, Marsat, Filippo&nbsp, Martelli, Ian, Martin, Rodica, Martin, Martinez, Denis, Martynov, Hossein&nbsp, Masalehdan, Ken&nbsp, Mason, Massera, Masserot, Thomas, Massinger, Mariela&nbsp, Masso-Reid, Simone&nbsp, Mastrogiovanni, Andrew&nbsp, Matas, Fabrice&nbsp, Matichard, Nergis&nbsp, Mavalvala, Emily&nbsp, Maynard, Joshua, Mccann, Richard&nbsp, Mccarthy, David, Mcclelland, Scott&nbsp, Mccormick, Lee&nbsp, Mcculler, Stephen, Mcguire, Connor&nbsp, Mcisaac, Jessica&nbsp, Mciver, David, Mcmanus, Terry&nbsp, Mcrae, Sean, Mcwilliams, Duncan&nbsp, Meacher, Grant, Meadors, Moritz&nbsp, Mehmet, Ajit, Mehta, Mejuto&nbsp, Villa, Andrew&nbsp, Melatos, Gregory&nbsp, Mendell, Adam, Mercer, Mereni, Kara&nbsp, Merfeld, Edmond, Merilh, Jonathan, Merritt, Mourad&nbsp, Merzougui, Syd&nbsp, Meshkov, Chris&nbsp, Messenger, Cody&nbsp, Messick, Remi&nbsp, Metzdorff, Patrick, Meyers, Fabian&nbsp, Meylahn, Ashish&nbsp, Mhaske, Miani, Haixing&nbsp, Miao, Ioannis&nbsp, Michaloliakos, Christophe&nbsp, Michel, Hannah&nbsp, Middleton, Leopoldo&nbsp, Milano, Andrewlawrence, Miller, Meg&nbsp, Millhouse, Joseph, Mills, Edoardo&nbsp, Milotti, Michael, Milovich-Goff, Olivier&nbsp, Minazzoli, Minenkov, Alec&nbsp, Mishkin, Chandra&nbsp, Mishra, Timesh&nbsp, Mistry, Sanjit&nbsp, Mitra, Valery, Mitrofanov, Guenakh&nbsp, Mitselmakher, Mittleman, Kentaro&nbsp, Mogushi, Satyanarayan, &nbsp, Mohapatra, Siddharth, Mohite, Manel&nbsp, Molina-Ruiz, Marina&nbsp, Mondin, Montani, Christopher, Moore, Moraru, Filip&nbsp, Morawski, Gerardo&nbsp, Moreno, Soichiro&nbsp, Morisaki, Benoit&nbsp, Mours, Conor, Mow-Lowry, Mozzon, Federico&nbsp, Muciaccia, Arunava&nbsp, Mukherjee, Debnandini&nbsp, Soma&nbsp, Subroto&nbsp, Nikhil&nbsp, Mukund, Mullavey, Jesper&nbsp, Munch, Erik, Muñiz, Peter, Murray, Nagar, Ilaria&nbsp, Nardecchia, Luca&nbsp, Naticchioni, Rajesh, Nayak, Benjamin, Neil, Joshua&nbsp, Neilson, Gijs&nbsp, Nelemans, Timothy, &nbsp, Nelson, Marina&nbsp, Nery, Ansel&nbsp, Neunzert, Kwan-yeung, Ng, Nguyen, Nichols, Shania, Nichols, Samaya&nbsp, Nissanke, Flavio&nbsp, Nocera, Minkyun&nbsp, Noh, North, Devon&nbsp, Nothard, Laura, Nuttall, Jason&nbsp, Oberling, Brendan, O’Brien, Gor&nbsp, Oganesyan, Greg, Ogin, John, Oh, Sanghoon, Oh, Ohme, Hiroaki&nbsp, Ohta, Marcos, Okada, Oliver, Olivetto, Oppermann, Oram, O’Reilly, Rich, Ormiston, Luis, Ortega, O’Shaughnessy, Serguei&nbsp, Ossokine, Osthelder, David, Ottaway, Harry&nbsp, Overmier, Ben, Owen, Alexander, Pace, Giulia&nbsp, Pagano, Michael, Page, Pagliaroli, Archana&nbsp, Pai, Siddhesh, Pai, Jordan, Palamos, Oleg&nbsp, Palashov, Cristiano&nbsp, Palomba, Howard&nbsp, Pan, Pratap, Panda, Tsun-ho&nbsp, Pang, Pankow, Pannarale, F, Brijesh, Pant, Paoletti, Paoli, Abhishek&nbsp, Parida, Parker, Daniela&nbsp, Pascucci, Pasqualetti, Passaquieti, Passuello, Barbara&nbsp, Patricelli, Ethan&nbsp, Payne, Brynley, Pearlstone, Thida, Pechsiri, Ari, Pedersen, Mike&nbsp, Pedraza, Arnaud&nbsp, Pele, Steven&nbsp, Penn, Albino&nbsp, Perego, Carlos, Perez, Perigois&nbsp, Périgois, Perreca, Stephane&nbsp, Perriès, Petermann, Harald, Pfeiffer, Phelps, Khun, Phukon, Ornella, Piccinni, Mikhael&nbsp, Pichot, Piendibene, Piergiovanni, Pierro, Gabriel&nbsp, Pillant, Laurent&nbsp, Pinard, Innocenzo, Pinto, Krzysztof&nbsp, Piotrzkowski, Pirello, Pitkin, Wolfango&nbsp, Plastino, Rosa&nbsp, Poggiani, Yat-tung, Pong, Ponrathnam, Pasquale&nbsp, Popolizio, Porter, Ed, Jade&nbsp, Powell, Atul, Prajapati, Kiran&nbsp, Prasai, Raghurama&nbsp, Prasanna, Geraint&nbsp, Pratten, Tanner&nbsp, Prestegard, Principe, Prodi, Leonid&nbsp, Prokhorov, Punturo, Puppo, Pürrer, Hong&nbsp, Quetschke, Pedro, Quinonez, Fred, Raab, Geert&nbsp, Raaijmakers, Hugh&nbsp, Radkins, Radulesco, Raffai, Hanna&nbsp, Rafferty, Sendhil&nbsp, Raja, Rajan&nbsp, Rajan, Binod&nbsp, Rajbhandari, Malik&nbsp, Rakhmanov, Karla, Ramirez, Antoni&nbsp, Ramos-Buades, Javed&nbsp, Rana, Kaushik&nbsp, Rao, Piero&nbsp, Rapagnani, Vivien&nbsp, Raymond, Razzano, Jocelyn&nbsp, Read, Tania&nbsp, Regimbau, Rei, Reid, David, Reitze, Rettegno, Fulvio&nbsp, Ricci, Colter, Richardson, Jonathan, Richardson, Paul, Ricker, Gunnar&nbsp, Riemenschneider, Keith&nbsp, Riles, Rizzo, Norna, Robertson, Florent&nbsp, Robinet, Rocchi, Ramon, Rodriguez-Soto, Loic&nbsp, Rolland, Jameson, Rollins, Vincent, Roma, Romanelli, Rocco&nbsp, Romano, Chandra, Romel, Isobel, Romero-Shaw, Janeen, Romie, Caitlin, Rose, Dakota&nbsp, Rose, Kyle&nbsp, Dorota&nbsp, Rosińska, Shawn, Rosofsky, Michael, Ross, Sheila&nbsp, Rowan, Samuel, Rowlinson, Palash, Roy, Santosh&nbsp, Roy, Paolo&nbsp, Ruggi, Guntis&nbsp, Rutins, Ryan, Surabhi&nbsp, Sachdev, Travis&nbsp, Sadecki, Mairi&nbsp, Sakellariadou, Salafia, Om, Livio&nbsp, Salconi, Muhammed&nbsp, Saleem, Samajdar, Eduardo, Sanchez, Luis, Sanchez, Sanchis-Gual, Jaclyn, Sanders, Kevin, Santiago, Edison&nbsp, Santos, Sarin, Sassolas, Sathyaprakash, B, Orion&nbsp, Sauter, Richard, Savage, Vaibhav&nbsp, Savant, Disha&nbsp, Sawant, Sihem&nbsp, Sayah, Dean&nbsp, Schaetzl, Schale, Mark&nbsp, Scheel, Scheuer, Patricia&nbsp, Schmidt, Roman&nbsp, Schnabel, Robert, &nbsp, Schofield, Axel&nbsp, Schönbeck, Emil&nbsp, Schreiber, Bernd, Schulte, Bernard, Schutz, Otto&nbsp, Schwarm, Eyal&nbsp, Schwartz, Jamie&nbsp, Scott, Susan, Scott, Seidel, Sellers, Anand, Sengupta, Noah&nbsp, Sennett, Sentenac, Valeria&nbsp, Sequino, Sergeev, Yoshinta&nbsp, Setyawati, Daniel, Shaddock, Shaffer, Selim, Shahriar, Sharma, Priyanka&nbsp, Shawhan, Hongyu&nbsp, Shen, Minori&nbsp, Shikauchi, Rosalie&nbsp, Shink, David, Shoemaker, Deirdre, Shoemaker, Keerti&nbsp, Shukla, Shyamsundar&nbsp, Shyamsundar, Karelle&nbsp, Siellez, Magdalena&nbsp, Sieniawska, Sigg, Leo, Singer, Divya&nbsp, Singh, Neha&nbsp, Ayatri&nbsp, Singha, Akshat&nbsp, Singhal, Alicia, Sintes, Sipala, Vasileios&nbsp, Skliris, Bram, &nbsp, Slagmolen, Teresa, Slaven-Blair, Jiri&nbsp, Smetana, Joshua, Smith, Rory, &nbsp, Smith, Surendranadh&nbsp, Somala, Edwin, Son, Siddharth&nbsp, Soni, Borja&nbsp, Sorazu, Viola&nbsp, Sordini, Fiodor&nbsp, Sorrentino, Tarun&nbsp, Souradeep, Sowell, Andrew, Spencer, Mario&nbsp, Spera, Amit, Srivastava, Varun&nbsp, Srivastava, Kai&nbsp, Staats, Cosmin&nbsp, Stachie, Standke, Daniele, Steer, Steinke, Steinlechner, Steinmeyer, Dane&nbsp, Stocks, David, Stops, Madeline&nbsp, Stover, Ken, Strain, Stratta, Amber&nbsp, Strunk, Sturani, Amber, Stuver, Sudhagar&nbsp, Sudhagar, Vivishek&nbsp, Sudhir, Tiffany, Summerscales, Ling&nbsp, Sun, Sunil&nbsp, Sunil, Ankan&nbsp, Sur, Jishnu&nbsp, Suresh, Patrick, Sutton, Bas, Swinkels, Marek, Szczepańczyk, Tacca, Simon, Tait, Colm&nbsp, Talbot, Andres, Tanasijczuk, David, Tanner, Duo&nbsp, Tao, Marton&nbsp, Tápai, Amauri&nbsp, Tapia, Enzo, Tapia&nbsp, San&nbsp, Martin, Jay, Tasson, Taylor, Rodrigo&nbsp, Tenorio, Lukas&nbsp, Terkowski, Manasadevi, Thirugnanasambandam, Thomas, Jonathan, Thompson, Sivananda, Thondapu, Keith, Thorne, Thrane, Calley, Tinsman, Saravanan, Saravanan, Shubhanshu&nbsp, Tiwari, Srishti&nbsp, Karl&nbsp, Toland, Mauro&nbsp, Tonelli, Zeno&nbsp, Tornasi, Alejandro&nbsp, Torres-Forné, Calum, Torrie, Iara&nbsp, Tosta&nbsp, e&nbsp, Melo, Töyrä, Emily, Trail, Travasso, Traylor, Maria, Tringali, Aashish&nbsp, Tripathee, Agata&nbsp, Trovato, Randy, Trudeau, Ka-wa, Tsang, Maggie&nbsp, Tse, Rhondale&nbsp, Tso, Leo&nbsp, Tsukada, Daichi&nbsp, Tsuna, Takuya&nbsp, Tsutsui, Margherita&nbsp, Turconi, Amit, Ubhi, Koh&nbsp, Ueno, Dennis&nbsp, Ugolini, Unnikrishnan, Cs, Alexander, Urban, Samantha, Usman, Andrei, Utina, Henning&nbsp, Vahlbruch, Vajente, Guillermo&nbsp, Valdes, Valentini, Vallisneri, Niels&nbsp, van&nbsp, Bakel, Martin&nbsp, Beuzekom, den&nbsp, Brand, Chris&nbsp, Van&nbsp, Den&nbsp, Broeck, Daniel, Vander-Hyde, der&nbsp, Schaaf, Joris, Van&nbsp, Heijningen, Marielle, van&nbsp, Veggel, Marco&nbsp, Vardaro, Vijay&nbsp, Varma, Steve&nbsp, Vass, Matyas&nbsp, Vasúth, Alberto&nbsp, Vecchio, Gabriele&nbsp, Vedovato, John&nbsp, Veitch, Peter, Veitch, Krishna&nbsp, Venkateswara, Gautam&nbsp, Venugopalan, Didier&nbsp, Verkindt, Doga&nbsp, Veske, Vetrano, Viceré, Aaron, Viets, Serena&nbsp, Vinciguerra, David, Vine, Jeanyves&nbsp, Vinet, Salvatore&nbsp, Vitale, Francisco&nbsp, Hernandez&nbsp, Vivanco, Thomas&nbsp, Helios&nbsp, Vocca, Cheryl&nbsp, Vorvick, Sergey, Vyatchanin, Andrew, Wade, Leslie, Wade, Wade, Rob&nbsp, Walet, Marissa&nbsp, Walker, Gavin, Wallace, Larry&nbsp, Wallace, Sinead&nbsp, Walsh, Jonathan, Wang, Sibo&nbsp, Wang, Wenhui, Wang, Yifan, Wang, Robert, Ward, Zane, Warden, Jim&nbsp, Warner, Was, Jennifer&nbsp, Watchi, Betsy&nbsp, Weaver, Li-wei&nbsp, Wei, Weinert, Alan, Weinstein, Rainer&nbsp, Weiss, Felix&nbsp, Wellmann, Linqing&nbsp, Wen, Weßels, Jonathan, Westhouse, Wette, 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fundamental physics, RS: FSE Grav. waves and fundamental physics, RS: FSE MSP, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aich, A., Aiello, L., Ain, A., Ajith, P., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., Aultoneal, K., Austin, C., Avendano, V., Babak, S., Bacon, P., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Baird, J., Baldaccini, F., Ballardin, G., Ballmer, S. W., Bals, A., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barkett, K., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Bécsy, B., Bejger, M., Belahcene, I., Bell, A. S., Beniwal, D., Benjamin, M. G., Bentley, J. D., Bergamin, F., Berger, B. K., Bergmann, G., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bidler, J., Biggs, E., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bissenbayeva, G., Bitossi, M., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossilkov, V., Bosveld, J., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brighenti, F., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannon, K. C., Cao, H., Cao, J., Carapella, G., Carbognani, F., Caride, S., Carney, M. F., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castañeda, J., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, O., Chakravarti, K., Chan, C., Chan, M., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chaturvedi, M., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Cheong, C. K., Chia, H. Y., Chiadini, F., Chierici, R., Chincarini, A., Chiummo, A., Cho, G., Cho, H. S., Cho, M., Christensen, N., Chu, Q., Chua, S., Chung, K. W., Chung, S., Ciani, G., Ciecielag, P., Cieślar, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, J. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D., Colleoni, M., Collette, C. G., Collins, C., Colpi, M., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Couvares, P., Covas, P. B., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Cripe, J., Croquette, M., Crowder, S. G., Cudell, J. -R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curylo, M., Canton, T. Dal, Dálya, G., Dana, A., Daneshgaran-Bajastani, L. M., D’Angelo, B., Danilishin, S. L., D’Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Debra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Delfavero, M., De Lillo, N., Del Pozzo, W., Demarchi, L. M., D’Emilio, V., Demos, N., Dent, T., De Pietri, R., De Rosa, R., De Rossi, C., Desalvo, R., de Varona, O., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz, M., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Downes, T. P., Drago, M., Driggers, J. C., Du, Z., Ducoin, J. -G., Dupej, P., Durante, O., D’Urso, D., Dwyer, S. E., Easter, P. J., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Ehrens, P., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Errico, L., Essick, R. C., Estelles, H., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fairhurst, S., Fan, X., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, E. C., Ferreira, T. A., Fidecaro, F., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fitz-Axen, M., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Forsyth, P. W. F., Fournier, J. -D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fritschel, P., Frolov, V. V., Fronzè, G., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Galaudage, S., Ganapathy, D., Gaonkar, S. G., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Gemme, G., Genin, E., Gennai, A., George, D., George, J., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giacomazzo, B., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Gill, K., Glanzer, J., Gniesmer, J., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gossan, S. E., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, E. M., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, Y., Gupta, A., Gupta, Anchal, Gupta, P., Gustafson, E. K., Gustafson, R., Haegel, L., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hasskew, R. K., Haster, C. -J., Haughian, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heitmann, H., Hellman, F., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Heurs, M., Hild, S., Hinderer, T., Hoback, S. Y., Hochheim, S., Hofgard, E., Hofman, D., Holgado, A. M., Holland, N. A., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Howell, E. J., Hoy, C. G., Huang, Y., Hübner, M. T., Huerta, E. A., Huet, D., Hughey, B., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Idzkowski, B., Iess, A., Inchauspe, H., Ingram, C., Intini, G., Isac, J. - M., Isi, M., Iyer, B. R., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jani, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jiang, J., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaufer, S., Kawabe, K., Kéfélian, F., Keitel, D., Keivani, A., Kennedy, R., Key, J. S., Khadka, S., Khalili, F. Y., Khan, I., Khan, S., Khan, Z. A., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, Chunglee, Kim, G. J., Kim, J. C., Kim, K., Kim, W., Kim, W. S., Kim, Y. -M., Kimball, C., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kleybolte, L., Klimenko, S., Knowles, T. D., Koch, P., Koehlenbeck, S. M., Koekoek, G., Koley, S., Kondrashov, V., Kontos, A., Koper, N., Korobko, M., Korth, W. Z., Kovalam, M., Kozak, D. B., Kringel, V., Krishnendu, N. V., Królak, A., Krupinski, N., Kuehn, G., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kumar, S., Kuo, L., Kutynia, A., Lackey, B. D., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., Lanza, R. K., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, C. H., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lehmann, J., Leroy, N., Letendre, N., Levin, Y., Li, A. K. Y., Li, J., Li, K., Li, T. G. F., Li, X., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, J., Liu, X., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., London, L. T., Longo, A., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lumaca, D., Lundgren, A. P., Ma, Y., Macas, R., Macfoy, S., Macinnis, M., Macleod, D. M., Macmillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magaña-Sandoval, F., Magee, R. M., Majorana, E., Maksimovic, I., Malik, A., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, V., Martynov, D. V., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Matichard, F., Mavalvala, N., Maynard, E., Mccann, J. J., Mccarthy, R., Mcclelland, D. E., Mccormick, S., Mcculler, L., Mcguire, S. C., Mcisaac, C., Mciver, J., Mcmanus, D. J., Mcrae, T., Mcwilliams, S. T., Meacher, D., Meadors, G. D., Mehmet, M., Mehta, A. K., Villa, E. Mejuto, Melatos, A., Mendell, G., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Middleton, H., Milano, L., Miller, A. L., Millhouse, M., Mills, J. C., Milotti, E., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Mishkin, A., Mishra, C., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Mo, G., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., Moreno, G., Morisaki, S., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukherjee, Subroto, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Nagar, A., Nardecchia, I., Naticchioni, L., Nayak, R. K., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Ng, K. Y., Ng, S., Nguyen, C., Nguyen, P., Nichols, D., Nichols, S. A., Nissanke, S., Nocera, F., Noh, M., North, C., Nothard, D., Nuttall, L. K., Oberling, J., O’Brien, B. D., Oganesyan, G., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Ohta, H., Okada, M. A., Oliver, M., Olivetto, C., Oppermann, P., Oram, Richard J., O’Reilly, B., Ormiston, R. G., Ortega, L. F., O’Shaughnessy, R., Ossokine, S., Osthelder, C., Ottaway, D. J., Overmier, H., Owen, B. J., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Panda, P. K., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Parida, A., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Payne, E., Pearlstone, B. L., Pechsiri, T. C., Pedersen, A. J., Pedraza, M., Pele, A., Penn, S., Perego, A., Perez, C. J., Périgois, C., Perreca, A., Perriès, S., Petermann, J., Pfeiffer, H. P., Phelps, M., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Piotrzkowski, K., Pirello, M., Pitkin, M., Plastino, W., Poggiani, R., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Powell, J., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Prestegard, T., Principe, M., Prodi, G. A., Prokhorov, L., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quinonez, P. J., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rafferty, H., Raja, S., Rajan, C., Rajbhandari, B., Rakhmanov, M., Ramirez, K. E., Ramos-Buades, A., Rana, Javed, Rao, K., Rapagnani, P., Raymond, V., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Rettegno, P., Ricci, F., Richardson, C. J., Richardson, J. W., Ricker, P. M., Riemenschneider, G., Riles, K., Rizzo, M., Robertson, N. A., Robinet, F., Rocchi, A., Rodriguez-Soto, R. D., Rolland, L., Rollins, J. G., Roma, V. J., Romanelli, M., Romano, R., Romel, C. L., Romero-Shaw, I. M., Romie, J. H., Rose, C. A., Rose, D., Rose, K., Rosińska, D., Rosofsky, S. G., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, P. K., Roy, Santosh, Roy, Soumen, Ruggi, P., Rutins, G., Ryan, K., Sachdev, S., Sadecki, T., Sakellariadou, M., Salafia, O. S., Salconi, L., Saleem, M., Samajdar, A., Sanchez, E. J., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Santiago, K. A., Santos, E., Sarin, N., Sassolas, B., Sathyaprakash, B. S., Sauter, O., Savage, R. L., Savant, V., Sawant, D., Sayah, S., Schaetzl, D., Schale, P., Scheel, M., Scheuer, J., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schulte, B. W., Schutz, B. F., Schwarm, O., Schwartz, E., Scott, J., Scott, S. M., Seidel, E., Sellers, D., Sengupta, A. S., Sennett, N., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D. A., Shaffer, T., Shahriar, M. S., Sharma, A., Sharma, P., Shawhan, P., Shen, H., Shikauchi, M., Shink, R., Shoemaker, D. H., Shoemaker, D. M., Shukla, K., Shyamsundar, S., Siellez, K., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Singhal, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Somala, S., Son, E. J., Soni, S., Sorazu, B., Sordini, V., Sorrentino, F., Souradeep, T., Sowell, E., Spencer, A. P., Spera, M., Srivastava, A. K., Srivastava, V., Staats, K., Stachie, C., Standke, M., Steer, D. A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stocks, D., Stops, D. J., Stover, M., Strain, K. A., Stratta, G., Strunk, A., Sturani, R., Stuver, A. L., Sudhagar, S., Sudhir, V., Summerscales, T. Z., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Tait, S. C., Talbot, C., Tanasijczuk, A. J., Tanner, D. B., Tao, D., Tápai, M., Tapia, A., Martin, E. N. Tapia San, Tasson, J. D., Taylor, R., Tenorio, R., Terkowski, L., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tinsman, C. L., Saravanan, T. R., Tiwari, Shubhanshu, Tiwari, S., Tiwari, V., Toland, K., Tonelli, M., Tornasi, Z., Torres-Forné, A., Torrie, C. I., Tosta e Melo, I., Töyrä, D., Trail, E. A., Travasso, F., Traylor, G., Tringali, M. C., Tripathee, A., Trovato, A., Trudeau, R. J., Tsang, K. W., Tse, M., Tso, R., Tsukada, L., Tsuna, D., Tsutsui, T., Turconi, M., Ubhi, A. S., Ueno, K., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Utina, A. C., Vahlbruch, H., Vajente, G., Valdes, G., Valentini, M., Vallisneri, M., van Bakel, N., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., Vander-Hyde, D. C., van der Schaaf, L., Van Heijningen, J. V., van Veggel, A. A., Vardaro, M., Varma, V., Vass, S., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venugopalan, G., Verkindt, D., Veske, D., Vetrano, F., Viceré, A., Viets, A. D., Vinciguerra, S., Vine, D. J., Vinet, J. -Y., Vitale, S., Vivanco, Francisco Hernandez, Vo, T., Vocca, H., Vorvick, C., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walet, R., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J. Z., Wang, S., Wang, W. H., Wang, Y. F., Ward, R. L., Warden, Z. A., Warner, J., Was, M., Watchi, J., Weaver, B., Wei, L. -W., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Weßels, P., Westhouse, J. W., Wette, K., Whelan, J. T., Whiting, B. F., Whittle, C., Wilken, D. M., Williams, D., Williams, R. D., Williamson, A. R., Willis, J. L., Willke, B., Winkler, W., Wipf, C. C., Wittel, H., Woan, G., Woehler, J., Wofford, J. K., Wong, C., Wright, J. L., Wu, D. S., Wysocki, D. M., Xiao, L., Yamamoto, H., Yang, L., Yang, Y., Yang, Z., Yap, M. J., Yazback, M., Yeeles, D. W., Yu, Hang, Yu, Haocun, Yuen, S. H. R., Zadrożny, A. K., Zadrożny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, T., Zhao, C., Zhao, G., Zhou, M., Zhou, Z., Zhu, X. J., Zimmerman, A. B., Zucker, M. E., Zweizig, J., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Nice Sophia Antipolis (... - 2019) (UNS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Abbott, R, Abbott, T, Abraham, S, Acernese, F, Ackley, K, Adams, C, Adhikari, R, Adya, V, Affeldt, C, Agathos, M, Agatsuma, K, Aggarwal, N, Aguiar, O, Aich, A, Aiello, L, Ain, A, Ajith, P, Allen, G, Allocca, A, Altin, P, Amato, A, Anand, S, Ananyeva, A, Anderson, S, Anderson, W, Angelova, S, Ansoldi, S, Antier, S, Appert, S, Arai, K, Araya, M, Areeda, J, Arene, M, Arnaud, N, Aronson, S, Arun, K, Ascenzi, S, Ashton, G, Aston, S, Astone, P, Aubin, F, Aufmuth, P, Aultoneal, K, Austin, C, Avendano, V, Babak, S, Bacon, P, Badaracco, F, Bader, M, Bae, S, Baer, A, Baird, J, Baldaccini, F, Ballardin, G, Ballmer, S, Bals, A, Balsamo, A, Baltus, G, Banagiri, S, Bankar, D, Bankar, R, Barayoga, J, Barbieri, C, Barish, B, Barker, D, Barkett, K, Barneo, P, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Bartos, I, Bassiri, R, Basti, A, Bawaj, M, Bayley, J, Bazzan, M, Becsy, B, Bejger, M, Belahcene, I, Bell, A, Beniwal, D, Benjamin, M, Bentley, J, Bergamin, F, Berger, B, Bergmann, G, Bernuzzi, S, Berry, C, Bersanetti, D, Bertolini, A, Betzwieser, J, Bhandare, R, Bhandari, A, Bidler, J, Biggs, E, Bilenko, I, Billingsley, G, Birney, R, Birnholtz, O, Biscans, S, Bischi, M, Biscoveanu, S, Bisht, A, Bissenbayeva, G, Bitossi, M, Bizouard, M, Blackburn, J, Blackman, J, Blair, C, Blair, D, Blair, R, Bobba, F, Bode, N, Boer, M, Boetzel, Y, Bogaert, G, Bondu, F, Bonilla, E, Bonnand, R, Booker, P, Boom, B, Bork, R, Boschi, V, Bose, S, Bossilkov, V, Bosveld, J, Bouffanais, Y, Bozzi, A, Bradaschia, C, Brady, P, Bramley, A, Branchesi, M, Brau, J, Breschi, M, Briant, T, Briggs, J, Brighenti, F, Brillet, A, Brinkmann, M, Brockill, P, Brooks, A, Brooks, J, Brown, D, Brunett, S, Bruno, G, Bruntz, R, Buikema, A, Bulik, T, Bulten, H, Buonanno, A, Buskulic, D, Byer, R, Cabero, M, Cadonati, L, Cagnoli, G, Cahillane, C, Bustillo, J, Callaghan, J, Callister, T, Calloni, E, Camp, J, Canepa, M, Cannon, K, Cao, H, Cao, J, Carapella, G, Carbognani, F, Caride, S, Carney, M, Carullo, G, Diaz, J, Casentini, C, Castaneda, J, Caudill, S, Cavaglia, M, Cavalier, F, Cavalieri, R, Cella, G, Cerda-Duran, P, Cesarini, E, Chaibi, O, Chakravarti, K, Chan, C, Chan, M, Chao, S, Charlton, P, Chase, E, Chassande-Mottin, E, Chatterjee, D, Chaturvedi, M, Chen, H, Chen, X, Chen, Y, Cheng, H, Cheong, C, Chia, H, Chiadini, F, Chierici, R, Chincarini, A, Chiummo, A, Cho, G, Cho, H, Cho, M, Christensen, N, Chu, Q, Chua, S, Chung, K, Chung, S, Ciani, G, Ciecielag, P, Cieslar, M, Ciobanu, A, Ciolfi, R, Cipriano, F, Cirone, A, Clara, F, Clark, J, Clearwater, P, Clesse, S, Cleva, F, Coccia, E, Cohadon, P, Cohen, D, Colleoni, M, Collette, C, Collins, C, Colpi, M, Constancio, M, Conti, L, Cooper, S, Corban, P, Corbitt, T, Cordero-Carrion, I, Corezzi, S, Corley, K, Cornish, N, Corre, D, Corsi, A, Cortese, S, Costa, C, Cotesta, R, Coughlin, M, Coughlin, S, Coulon, J, Countryman, S, Couvares, P, Covas, P, Coward, D, Cowart, M, Coyne, D, Coyne, R, Creighton, J, Creighton, T, Cripe, J, Croquette, M, Crowder, S, Cudell, J, Cullen, T, Cumming, A, Cummings, R, Cunningham, L, Cuoco, E, Curylo, M, Canton, T, Dalya, G, Dana, A, Daneshgaran-Bajastani, L, D'Angelo, B, Danilishin, S, D'Antonio, S, Danzmann, K, Darsow-Fromm, C, Dasgupta, A, Datrier, L, Dattilo, V, Dave, I, Davier, M, Davies, G, Davis, D, Daw, E, Debra, D, Deenadayalan, M, Degallaix, J, De Laurentis, M, Deleglise, S, Delfavero, M, De Lillo, N, Del Pozzo, W, Demarchi, L, D'Emilio, V, Demos, N, Dent, T, De Pietri, R, De Rosa, R, De Rossi, C, Desalvo, R, de Varona, O, Dhurandhar, S, Diaz, M, Diaz-Ortiz, M, Dietrich, T, Di Fiore, L, Di Fronzo, C, Di Giorgio, C, Di Giovanni, F, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Ding, B, Di Pace, S, Di Palma, I, Di Renzo, F, Divakarla, A, Dmitriev, A, Doctor, Z, Donovan, F, Dooley, K, Doravari, S, Dorrington, I, Downes, T, Drago, M, Driggers, J, Du, Z, Ducoin, J, Dupej, P, Durante, O, D'Urso, D, Dwyer, S, Easter, P, Eddolls, G, Edelman, B, Edo, T, Edy, O, Effler, A, Ehrens, P, Eichholz, J, Eikenberry, S, Eisenmann, M, Eisenstein, R, Ejlli, A, Errico, L, Essick, R, Estelles, H, Estevez, D, Etienne, Z, Etzel, T, Evans, M, Evans, T, Ewing, B, Fafone, V, Fairhurst, S, Fan, X, Farinon, S, Farr, B, Farr, W, Fauchon-Jones, E, Favata, M, Fays, M, Fazio, M, Feicht, J, Fejer, M, Feng, F, Fenyvesi, E, Ferguson, D, Fernandez-Galiana, A, Ferrante, I, Ferreira, E, Ferreira, T, Fidecaro, F, Fiori, I, Fiorucci, D, Fishbach, M, Fisher, R, Fittipaldi, R, Fitz-Axen, M, Fiumara, V, Flaminio, R, Floden, E, Flynn, E, Fong, H, Font, J, Forsyth, P, Fournier, J, Frasca, S, Frasconi, F, Frei, Z, Freise, A, Frey, R, Frey, V, Fritschel, P, Frolov, V, Fronze, G, Fulda, P, Fyffe, M, Gabbard, H, Gadre, B, Gaebel, S, Gair, J, Galaudage, S, Ganapathy, D, Gaonkar, S, Garcia-Quiros, C, Garufi, F, Gateley, B, Gaudio, S, Gayathri, V, Gemme, G, Genin, E, Gennai, A, George, D, George, J, Gergely, L, Ghonge, S, Ghosh, A, Ghosh, S, Giacomazzo, B, Giaime, J, Giardina, K, Gibson, D, Gier, C, Gill, K, Glanzer, J, Gniesmer, J, Godwin, P, Goetz, E, Goetz, R, Gohlke, N, Goncharov, B, Gonzalez, G, Gopakumar, A, Gossan, S, Gosselin, M, Gouaty, R, Grace, B, Grado, A, Granata, M, Grant, A, Gras, S, Grassia, P, Gray, C, Gray, R, Greco, G, Green, A, Green, R, Gretarsson, E, Griggs, H, Grignani, G, Grimaldi, A, Grimm, S, Grote, H, Grunewald, S, Gruning, P, Guidi, G, Guimaraes, A, Guixe, G, Gulati, H, Guo, Y, Gupta, A, Gupta, P, Gustafson, E, Gustafson, R, Haegel, L, Halim, O, Hall, E, Hamilton, E, Hammond, G, Haney, M, Hanke, M, Hanks, J, Hanna, C, Hannam, M, Hannuksela, O, Hansen, T, Hanson, J, Harder, T, Hardwick, T, Haris, K, Harms, J, Harry, G, Harry, I, Hasskew, R, Haster, C, Haughian, K, Hayes, F, Healy, J, Heidmann, A, Heintze, M, Heinze, J, Heitmann, H, Hellman, F, Hello, P, Hemming, G, Hendry, M, Heng, I, Hennes, E, Hennig, J, Heurs, M, Hild, S, Hinderer, T, Hoback, S, Hochheim, S, Hofgard, E, Hofman, D, Holgado, A, Holland, N, Holt, K, Holz, D, Hopkins, P, Horst, C, Hough, J, Howell, E, Hoy, C, Huang, Y, Hubner, M, Huerta, E, Huet, D, Hughey, B, Hui, V, Husa, S, Huttner, S, Huxford, R, Huynh-Dinh, T, Idzkowski, B, Iess, A, Inchauspe, H, Ingram, C, Intini, G, Isac, J, Isi, M, Iyer, B, Jacqmin, T, Jadhav, S, James, A, Jani, K, Janthalur, N, Jaranowski, P, Jariwala, D, Jaume, R, Jenkins, A, Jiang, J, Johns, G, Jones, A, Jones, D, Jones, J, Jones, P, Jones, R, Jonker, R, Ju, L, Junker, J, Kalaghatgi, C, Kalogera, V, Kamai, B, Kandhasamy, S, Kang, G, Kanner, J, Kapadia, S, Karki, S, Kashyap, R, Kasprzack, M, Kastaun, W, Katsanevas, S, Katsavounidis, E, Katzman, W, Kaufer, S, Kawabe, K, Kefelian, F, Keitel, D, Keivani, A, Kennedy, R, Key, J, Khadka, S, Khalili, F, Khan, I, Khan, S, Khan, Z, Khazanov, E, Khetan, N, Khursheed, M, Kijbunchoo, N, Kim, C, Kim, G, Kim, J, Kim, K, Kim, W, Kim, Y, Kimball, C, King, P, Kinley-Hanlon, M, Kirchhoff, R, Kissel, J, Kleybolte, L, Klimenko, S, Knowles, T, Koch, P, Koehlenbeck, S, Koekoek, G, Koley, S, Kondrashov, V, Kontos, A, Koper, N, Korobko, M, Korth, W, Kovalam, M, Kozak, D, Kringel, V, Krishnendu, N, Krolak, A, Krupinski, N, Kuehn, G, Kumar, A, Kumar, P, Kumar, R, Kumar, S, Kuo, L, Kutynia, A, Lackey, B, Laghi, D, Lalande, E, Lam, T, Lamberts, A, Landry, M, Lane, B, Lang, R, Lange, J, Lantz, B, Lanza, R, La Rosa, I, Lartaux-Vollard, A, Lasky, P, Laxen, M, Lazzarini, A, Lazzaro, C, Leaci, P, Leavey, S, Lecoeuche, Y, Lee, C, Lee, H, Lee, J, Lee, K, Lehmann, J, Leroy, N, Letendre, N, Levin, Y, Li, A, Li, J, Li, K, Li, T, Li, X, Linde, F, Linker, S, Linley, J, Littenberg, T, Liu, J, Liu, X, Llorens-Monteagudo, M, Lo, R, Lockwood, A, London, L, Longo, A, Lorenzini, M, Loriette, V, Lormand, M, Losurdo, G, Lough, J, Lousto, C, Lovelace, G, Luck, H, Lumaca, D, Lundgren, A, Ma, Y, Macas, R, Macfoy, S, Macinnis, M, Macleod, D, Macmillan, I, Macquet, A, Hernandez, I, Magana-Sandoval, F, Magee, R, Majorana, E, Maksimovic, I, Malik, A, Man, N, Mandic, V, Mangano, V, Mansell, G, Manske, M, Mantovani, M, Mapelli, M, Marchesoni, F, Marion, F, Marka, S, Marka, Z, Markakis, C, Markosyan, A, Markowitz, A, Maros, E, Marquina, A, Marsat, S, Martelli, F, Martin, I, Martin, R, Martinez, V, Martynov, D, Masalehdan, H, Mason, K, Massera, E, Masserot, A, Massinger, T, Masso-Reid, M, Mastrogiovanni, S, Matas, A, Matichard, F, Mavalvala, N, Maynard, E, Mccann, J, Mccarthy, R, Mcclelland, D, Mccormick, S, Mcculler, L, Mcguire, S, Mcisaac, C, Mciver, J, Mcmanus, D, Mcrae, T, Mcwilliams, S, Meacher, D, Meadors, G, Mehmet, M, Mehta, A, Villa, E, Melatos, A, Mendell, G, Mercer, R, Mereni, L, Merfeld, K, Merilh, E, Merritt, J, Merzougui, M, Meshkov, S, Messenger, C, Messick, C, Metzdorff, R, Meyers, P, Meylahn, F, Mhaske, A, Miani, A, Miao, H, Michaloliakos, I, Michel, C, Middleton, H, Milano, L, Miller, A, Millhouse, M, Mills, J, Milotti, E, Milovich-Goff, M, Minazzoli, O, Minenkov, Y, Mishkin, A, Mishra, C, Mistry, T, Mitra, S, Mitrofanov, V, Mitselmakher, G, Mittleman, R, Mo, G, Mogushi, K, Mohapatra, S, Mohite, S, Molina-Ruiz, M, Mondin, M, Montani, M, Moore, C, Moraru, D, Morawski, F, Moreno, G, Morisaki, S, Mours, B, Mow-Lowry, C, Mozzon, S, Muciaccia, F, Mukherjee, A, Mukherjee, D, Mukherjee, S, Mukund, N, Mullavey, A, Munch, J, Muniz, E, Murray, P, Nagar, A, Nardecchia, I, Naticchioni, L, Nayak, R, Neil, B, Neilson, J, Nelemans, G, Nelson, T, Nery, M, Neunzert, A, Ng, K, Ng, S, Nguyen, C, Nguyen, P, Nichols, D, Nichols, S, Nissanke, S, Nocera, F, Noh, M, North, C, Nothard, D, Nuttall, L, Oberling, J, O'Brien, B, Oganesyan, G, Ogin, G, Oh, J, Oh, S, Ohme, F, Ohta, H, Okada, M, Oliver, M, Olivetto, C, Oppermann, P, Oram, R, O'Reilly, B, Ormiston, R, Ortega, L, O'Shaughnessy, R, Ossokine, S, Osthelder, C, Ottaway, D, Overmier, H, Owen, B, Pace, A, Pagano, G, Page, M, Pagliaroli, G, Pai, A, Pai, S, Palamos, J, Palashov, O, Palomba, C, Pan, H, Panda, P, Pang, P, Pankow, C, Pannarale, F, Pant, B, Paoletti, F, Paoli, A, Parida, A, Parker, W, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patricelli, B, Payne, E, Pearlstone, B, Pechsiri, T, Pedersen, A, Pedraza, M, Pele, A, Penn, S, Perego, A, Perez, C, Perigois, C, Perreca, A, Perries, S, Petermann, J, Pfeiffer, H, Phelps, M, Phukon, K, Piccinni, O, Pichot, M, Piendibene, M, Piergiovanni, F, Pierro, V, Pillant, G, Pinard, L, Pinto, I, Piotrzkowski, K, Pirello, M, Pitkin, M, Plastino, W, Poggiani, R, Pong, D, Ponrathnam, S, Popolizio, P, Porter, E, Powell, J, Prajapati, A, Prasai, K, Prasanna, R, Pratten, G, Prestegard, T, Principe, M, Prodi, G, Prokhorov, L, Punturo, M, Puppo, P, Purrer, M, Qi, H, Quetschke, V, Quinonez, P, Raab, F, Raaijmakers, G, Radkins, H, Radulesco, N, Raffai, P, Rafferty, H, Raja, S, Rajan, C, Rajbhandari, B, Rakhmanov, M, Ramirez, K, Ramos-Buades, A, Rana, J, Rao, K, Rapagnani, P, Raymond, V, Razzano, M, Read, J, Regimbau, T, Rei, L, Reid, S, Reitze, D, Rettegno, P, Ricci, F, Richardson, C, Richardson, J, Ricker, P, Riemenschneider, G, Riles, K, Rizzo, M, Robertson, N, Robinet, F, Rocchi, A, Rodriguez-Soto, R, Rolland, L, Rollins, J, Roma, V, Romanelli, M, Romano, R, Romel, C, Romero-Shaw, I, Romie, J, Rose, C, Rose, D, Rose, K, Rosinska, D, Rosofsky, S, Ross, M, Rowan, S, Rowlinson, S, Roy, P, Roy, S, Ruggi, P, Rutins, G, Ryan, K, Sachdev, S, Sadecki, T, Sakellariadou, M, Salafia, O, Salconi, L, Saleem, M, Samajdar, A, Sanchez, E, Sanchez, L, Sanchis-Gual, N, Sanders, J, Santiago, K, Santos, E, Sarin, N, Sassolas, B, Sathyaprakash, B, Sauter, O, Savage, R, Savant, V, Sawant, D, Sayah, S, Schaetzl, D, Schale, P, Scheel, M, Scheuer, J, Schmidt, P, Schnabel, R, Schofield, R, Schonbeck, A, Schreiber, E, Schulte, B, Schutz, B, Schwarm, O, Schwartz, E, Scott, J, Scott, S, Seidel, E, Sellers, D, Sengupta, A, Sennett, N, Sentenac, D, Sequino, V, Sergeev, A, Setyawati, Y, Shaddock, D, Shaffer, T, Shahriar, M, Sharma, A, Sharma, P, Shawhan, P, Shen, H, Shikauchi, M, Shink, R, Shoemaker, D, Shukla, K, Shyamsundar, S, Siellez, K, Sieniawska, M, Sigg, D, Singer, L, Singh, D, Singh, N, Singha, A, Singhal, A, Sintes, A, Sipala, V, Skliris, V, Slagmolen, B, Slaven-Blair, T, Smetana, J, Smith, J, Smith, R, Somala, S, Son, E, Soni, S, Sorazu, B, Sordini, V, Sorrentino, F, Souradeep, T, Sowell, E, Spencer, A, Spera, M, Srivastava, A, Srivastava, V, Staats, K, Stachie, C, Standke, M, Steer, D, Steinke, M, Steinlechner, J, Steinlechner, S, Steinmeyer, D, Stocks, D, Stops, D, Stover, M, Strain, K, Stratta, G, Strunk, A, Sturani, R, Stuver, A, Sudhagar, S, Sudhir, V, Summerscales, T, Sun, L, Sunil, S, Sur, A, Suresh, J, Sutton, P, Swinkels, B, Szczepanczyk, M, Tacca, M, Tait, S, Talbot, C, Tanasijczuk, A, Tanner, D, Tao, D, Tapai, M, Tapia, A, Martin, E, Tasson, J, Taylor, R, Tenorio, R, Terkowski, L, Thirugnanasambandam, M, Thomas, M, Thomas, P, Thompson, J, Thondapu, S, Thorne, K, Thrane, E, Tinsman, C, Saravanan, T, Tiwari, S, Tiwari, V, Toland, K, Tonelli, M, Tornasi, Z, Torres-Forne, A, Torrie, C, Tosta e Melo, I, Toyra, D, Trail, E, Travasso, F, Traylor, G, Tringali, M, Tripathee, A, Trovato, A, Trudeau, R, Tsang, K, Tse, M, Tso, R, Tsukada, L, Tsuna, D, Tsutsui, T, Turconi, M, Ubhi, A, Ueno, K, Ugolini, D, Unnikrishnan, C, Urban, A, Usman, S, Utina, A, Vahlbruch, H, Vajente, G, Valdes, G, Valentini, M, Vallisneri, M, van Bakel, N, van Beuzekom, M, van den Brand, J, Van Den Broeck, C, Vander-Hyde, D, van der Schaaf, L, Van Heijningen, J, van Veggel, A, Vardaro, M, Varma, V, Vass, S, Vasuth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P, Venkateswara, K, Venugopalan, G, Verkindt, D, Veske, D, Vetrano, F, Vicere, A, Viets, A, Vinciguerra, S, Vine, D, Vinet, J, Vitale, S, Vivanco, F, Vo, T, Vocca, H, Vorvick, C, Vyatchanin, S, Wade, A, Wade, L, Wade, M, Walet, R, Walker, M, Wallace, G, Wallace, L, Walsh, S, Wang, J, Wang, S, Wang, W, Wang, Y, Ward, R, Warden, Z, Warner, J, Was, M, Watchi, J, Weaver, B, Wei, L, Weinert, M, Weinstein, A, Weiss, R, Wellmann, F, Wen, L, Wessels, P, Westhouse, J, Wette, K, Whelan, J, Whiting, B, Whittle, C, Wilken, D, Williams, D, Williams, R, Williamson, A, Willis, J, Willke, B, Winkler, W, Wipf, C, Wittel, H, Woan, G, Woehler, J, Wofford, J, Wong, C, Wright, J, Wu, D, Wysocki, D, Xiao, L, Yamamoto, H, Yang, L, Yang, Y, Yang, Z, Yap, M, Yazback, M, Yeeles, D, Yu, H, Yuen, S, Zadrozny, A, Zanolin, M, Zelenova, T, Zendri, J, Zevin, M, Zhang, J, Zhang, L, Zhang, T, Zhao, C, Zhao, G, Zhou, M, Zhou, Z, Zhu, X, Zimmerman, A, Zucker, M, Zweizig, J, IoP (FNWI), Faculty of Science, Gravitation and Astroparticle Physics Amsterdam, Other Research IHEF (IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The LIGO Scientific Collaboration, The Virgo Collaboration, Arene, M., Becsy, B., Bustillo, J. C., Diaz, J. C., Castaneda, J., Cavaglia, M., Cerda-Duran, P., Cieslar, M., Cordero-Carrion, I., Canton, T. D., Dalya, G., D'Angelo, B., D'Antonio, S., Deleglise, S., D'Emilio, V., Diaz, M. C., D'Urso, D., Fronze, G., Garcia-Quiros, C., Ghosh, A., Gonzalez, G., Guixe, G., Hubner, M. T., Isac, J. -M., Kefelian, F., Kim, C., Krolak, A., Kumar, R., Luck, H., Hernandez, I. M., Magana-Sandoval, F., Marka, S., Marka, Z., Villa, E. M., Mukherjee, A., Muniz, E. A., O'Brien, B. D., Oram, R. J., O'Reilly, B., O'Shaughnessy, R., Perigois, C., Perries, S., Pinto, I., Purrer, M., Rana, J., Rosinska, D., Roy, S., Schonbeck, A., Szczepanczyk, M. J., Tapai, M., Martin, E. N. T. S., Torres-Forne, A., Toyra, D., Vasuth, M., Vicere, A., Vivanco, F. H., Wessels, P., Yu, H., Zadrozny, A. K., and Zadrozny, A.
Subjects: Technology, Gravitational Waves, Open Data, O1, O2, LIGO, Virgo, Astronomy, Strain measurement, Gravitational Wave, open data, Data representation and management, Gravitational Waves, GWOSC, Scientific databases, gravitational waves, 01 natural sciences, General Relativity and Quantum Cosmology, Software, Documentation, DESIGN, Open Data, Computer software, Data products, LIGO, QC, 12-AXIS VIBRATION ISOLATION, media_common, Settore FIS/01, 0303 health sciences, Gravitational effects, BINARY MERGERS, Computer Science Applications, Open data, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Open science, Astrophysics - Instrumentation and Methods for Astrophysics, data analysis method, gr-qc, media_common.quotation_subject, Real-time computing, FOS: Physical sciences, O2, PUBLIC ADVANCED LIGO, General Relativity and Quantum Cosmology (gr-qc), Gravity waves, programming, O1, 03 medical and health sciences, QA76.75-76.765, Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik, SDG 17 - Partnerships for the Goals, GWOSC, Scientific databases, Data representation and management, Gravitational Waves, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, GRAVITATIONAL-WAVE CATALOG, Instrumentation and Methods for Astrophysics (astro-ph.IM), STFC, Astrophysique, 030304 developmental biology, Science & Technology, business.industry, Gravitational wave, Virgo, gravitational radiation, RCUK, Strain data, Data-quality information, Computer Science, Software Engineering, gravitational radiation detector, detector: sensitivity, Scientific database, monitoring, VIRGO, Sky, gravitational radiation: emission, Computer Science, ddc:004, business, astro-ph.IM
Abstract: Abbot, Rich, et al. (Virgo and MAGIC Collaboration), Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software., The authors gratefully acknowledge the support of the United States National Science Foundation (NSF) for the construction and operation of the LIGO Laboratory and Advanced LIGO as well as the Science and Technology Facilities Council (STFC) of the United Kingdom, the Max-Planck-Society (MPS), and the State of Niedersachsen/Germany for support of the construction of Advanced LIGO and construction and operation of the GEO600 detector. Additional support for Advanced LIGO was provided by the Australian Research Council. The authors gratefully acknowledge the Italian Istituto Nazionale di Fisica Nucleare (INFN), the French Centre National de la Recherche Scientifique (CNRS) and the Foundation for Fundamental Research on Matter supported by the Netherlands Organisation for Scientific Research, for the construction and operation of the Virgo detector and the creation and support of the EGO consortium. The authors also gratefully acknowledge research support from these agencies as well as by the Council of Scientific and Industrial Research of India, the Department of Science and Technology, India, the Science & Engineering Research Board (SERB), India, the Ministry of Human Resource Development, India, the Spanish Agencia Estatal de Investigación, the Vicepresidència i Conselleria d’Innovació, Recerca i Turisme and the Conselleria d’Educació i Universitat del Govern de les Illes Balears, the Conselleria d’Educació, Investigació, Cultura i Esport de la Generalitat Valenciana, the National Science Centre of Poland, the Swiss National Science Foundation (SNSF), the Russian Foundation for Basic Research, the Russian Science Foundation, the European Commission, the European Regional Development Funds (ERDF), the Royal Society, the Scottish Funding Council, the Scottish Universities Physics Alliance, the Hungarian Scientific Research Fund (OTKA), the Lyon Institute of Origins (LIO), the Paris Île-de-France Region, the National Research, Development and Innovation Office Hungary (NKFIH), the National Research Foundation of Korea, Industry Canada and the Province of Ontario through the Ministry of Economic Development and Innovation, the Natural Science and Engineering Research Council Canada, the Canadian Institute for Advanced Research, the Brazilian Ministry of Science, Technology, Innovations, and Communications, the International Center for Theoretical Physics South American Institute for Fundamental Research (ICTP-SAIFR), the Research Grants Council of Hong Kong, the National Natural Science Foundation of China (NSFC), the Leverhulme Trust, the Research Corporation, the Ministry of Science and Technology (MOST), Taiwan and the Kavli Foundation. The authors gratefully acknowledge the support of the NSF, STFC, INFN and CNRS for provision of computational resources.
Published: 2021
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46. The prognostic impact of histology in esophageal and esophago-gastric junction adenocarcinoma

Author: Roberto Fiocca, Anna Tomezzoli, Jari Räsänen, Paola Spaggiari, Deborah Malvi, Luca Bottiglieri, Luca Albarello, Elena Bonora, Federica Grillo, Antonietta D'Errico, Luca Mastracci, Uberto Fumagalli Romario, G Raulli, Giovanni de Manzoni, Marialuisa Lugaresi, Ari Ristimäki, Sandro Mattioli, Riccardo Rosati, Kausilia K. Krishnadath, Fiocca, R., Mastracci, L., Lugaresi, M., Grillo, F., D'Errico, A., Malvi, D., Spaggiari, P., Tomezzoli, A., Albarello, L., Ristimaki, A., Bottiglieri, L., Bonora, E., Krishnadath, K. K., Raulli, G. D., Rosati, R., Romario, U. F., De Manzoni, G., Rasanen, J., Mattioli, S., Department of Pathology, HUSLAB, University of Helsinki, Helsinki University Hospital Area, HUS Diagnostic Center, HUS Heart and Lung Center, III kirurgian klinikka, EACSGE Study Group, Fiocca R., Mastracci L., Lugaresi M., Grillo F., D'errico A., Malvi D., Spaggiari P., Tomezzoli A., Albarello L., Ristimaki A., Bottiglieri L., Bonora E., Krishnadath K.K., Raulli G.D., Rosati R., Romario U.F., De Manzoni G., Rasanen J., and Mattioli S.
Subjects: Cancer Research, medicine.medical_specialty, Multivariate analysis, Histology, esophageal adenocarcinoma, Esophageal adenocarcinoma, Esophago-gastric junction adenocarcinoma, Prognosis, 3122 Cancers, Stage ii, Lower risk, Gastroenterology, THERAPY, Article, CLASSIFICATION, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, CARDIA, EPIDEMIOLOGY, Stage (cooking), Esophago gastric junction, SIGNET-RING CELLS, RC254-282, business.industry, Poorly differentiated, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, CANCER, 3. Good health, Oncology, GASTROESOPHAGEAL JUNCTION, 030220 oncology & carcinogenesis, SURVIVAL, Adenocarcinoma, 030211 gastroenterology & hepatology, Human medicine, business, GASTRIC-CARCINOMA
Abstract: Stage significantly affects survival of esophageal and esophago-gastric junction adenocarcinomas (EA/EGJAs), however, limited evidence for the prognostic role of histologic subtypes is available. The aim of the study was to describe a morphologic approach to EA/EGJAs and assess its discriminating prognostic power. Histologic slides from 299 neoadjuvant treatment-naïve EA/EGJAs, resected in five European Centers, were retrospectively reviewed. Morphologic features were re-assessed and correlated with survival. In glandular adenocarcinomas (240/299 cases—80%), WHO grade and tumors with a poorly differentiated component ≥6% were the most discriminant factors for survival (both p &lt, 0.0001), distinguishing glandular well-differentiated from poorly differentiated adenocarcinomas. Two prognostically different histologic groups were identified: the lower risk group, comprising glandular well-differentiated (34.4%) and rare variants, such as mucinous muconodular carcinoma (2.7%) and diffuse desmoplastic carcinoma (1.7%), versus the higher risk group, comprising the glandular poorly differentiated subtype (45.8%), including invasive mucinous carcinoma (5.7%), diffuse anaplastic carcinoma (3%), mixed carcinoma (6.7%) (CSS p &lt, 0.0001, DFS p = 0.001). Stage (p &lt, 0.0001), histologic groups (p = 0.001), age &gt, 72 years (p = 0.008), and vascular invasion (p = 0.015) were prognostically significant in the multivariate analysis. The combined evaluation of stage/histologic group identified 5-year cancer-specific survival ranging from 87.6% (stage II, lower risk) to 14% (stage IVA, higher risk). Detailed characterization of histologic subtypes contributes to EA/EGJA prognostic prediction.
Published: 2021

47. Role of prenatal magnetic resonance imaging in fetuses with isolated anomalies of corpus callosum: multinational study

Author: Sileo F. G., Pilu G., Prayer D., Rizzo G., Khalil A., Managanaro L., Volpe P., Van Mieghem T., Bertucci E., Morales Rosello J., Facchinetti F., Di Mascio D., Stampalija T., Buca D., Tinari S., Oronzi L., Ercolani G., D'Amico A., Matarrelli B., Cerra C., Fantasia I., Pasquini L., Masini G., Olivieri C., Ghi T., Frusca T., Dall'Asta A., Visentin S., Cosmi E., D'Errico I., Villalain C., Quintero O. M., Giancotti A., D'Ambrosio V., Antonelli A., Caulo M., Panar V., De Santis M., Mappa I., Prefumo F., Pinelli L., Loscalzo G., Bracalente G., Liberati M., Filippi E., Trincia E., Pateisky P., Kiss H., Curado J., Almeida M., Santos A., Galindo A., D'Antonio F., Sileo F.G., Pilu G., Prayer D., Rizzo G., Khalil A., Managanaro L., Volpe P., Van Mieghem T., Bertucci E., Morales Rosello J., Facchinetti F., Di Mascio D., Stampalija T., Buca D., Tinari S., Oronzi L., Ercolani G., D'Amico A., Matarrelli B., Cerra C., Fantasia I., Pasquini L., Masini G., Olivieri C., Ghi T., Frusca T., Dall'Asta A., Visentin S., Cosmi E., D'Errico I., Villalain C., Quintero O.M., Giancotti A., D'Ambrosio V., Antonelli A., Caulo M., Panar V., De Santis M., Mappa I., Prefumo F., Pinelli L., Loscalzo G., Bracalente G., Liberati M., Filippi E., Trincia E., Pateisky P., Kiss H., Curado J., Almeida M., Santos A., Galindo A., D'Antonio F., Sileo, Fg, Pilu, G, Prayer, D, Rizzo, G, Khalil, A, Managanaro, L, Volpe, P, Van Mieghem, T, Bertucci, E, Rosello, Jm, Facchinetti, F, Di Mascio, D, Stampalija, T, Buca, D, Tinari, S, Oronzi, L, Ercolani, G, D'Amico, A, Matarrelli, B, Cerra, C, Fantasia, I, Pasquini, L, Masini, G, Olivieri, C, Ghi, T, Frusca, T, Dall'Asta, A, Visentin, S, Cosmi, E, D'Errico, I, Villalain, C, Quintero, Om, Giancotti, A, D'Ambrosio, V, Antonelli, A, Caulo, M, Panara, V, De Santis, M, Mappa, I, Prefumo, F, Pinelli, L, Loscalzo, G, Bracalente, G, Liberati, M, Filippi, E, Trincia, E, Pateisky, P, Kiss, H, Curado, J, Almeida, M, Santos, A, Galindo, A, and D'Antonio, F
Subjects: Fetal magnetic resonance imaging, Adult, Prenatal Diagnosi, medicine.medical_specialty, Logistic Model, Prenatal diagnosis, Gestational Age, Nervous System Malformations, Corpus callosum, Ultrasonography, Prenatal, Corpus Callosum, corpus callosum, Nervous System Malformation, Fetus, Pregnancy, Retrospective Studie, medicine, Humans, Radiology, Nuclear Medicine and imaging, Fetu, fetal magnetic resonance imaging, Agenesis of the corpus callosum, Retrospective Studies, prenatal diagnosis, Radiological and Ultrasound Technology, medicine.diagnostic_test, MRI, central nervous system, fetal ultrasound, neurosonography, business.industry, Ultrasound, Obstetrics and Gynecology, Magnetic resonance imaging, General Medicine, medicine.disease, Magnetic Resonance Imaging, Logistic Models, Reproductive Medicine, Settore MED/40, Female, Radiology, Agenesis of Corpus Callosum, business, Fetal medicine, Human
Abstract: Objective To assess the performance of fetal magnetic resonance imaging (MRI) in detecting associated anomalies in fetuses diagnosed with isolated corpus callosal (CC) anomaly on multiplanar ultrasound evaluation of the fetal brain (neurosonography). Methods This was a multicenter, retrospective cohort study involving 14 fetal medicine centers in Italy, UK, Portugal, Canada, Austria and Spain. Inclusion criteria were fetuses with an apparently isolated CC anomaly, defined as an anomaly of the CC and no other additional central nervous system (CNS) or extra-CNS abnormality detected on expert ultrasound, including multiplanar neurosonography; normal karyotype; maternal age >= 18 years; and gestational age at diagnosis >= 18 weeks. The primary outcome was the rate of additional CNS abnormalities detected exclusively on fetal MRI within 2 weeks following neurosonography. The secondary outcomes were the rate of additional abnormalities according to the type of CC abnormality (complete (cACC) or partial (pACC) agenesis of the CC) and the rate of additional anomalies detected only on postnatal imaging or at postmortem examination. Results A total of 269 fetuses with a sonographic prenatal diagnosis of apparently isolated CC anomalies (207 with cACC and 62 with pACC) were included in the analysis. Additional structural anomalies of the CNS were detected exclusively on prenatal MRI in 11.2% (30/269) of cases, with malformations of cortical development representing the most common type of anomaly. When stratifying the analysis according to the type of CC anomaly, the rate of associated anomalies detected exclusively on MRI was 11.6% (24/207) in cACC cases and 9.7% (6/62) in pACC cases. On multivariate logistic regression analysis, only maternal body mass index was associated independently with the likelihood of detecting associated anomalies on MRI (odds ratio, 1.07 (95% CI, 1.01-1.14); P = 0.03). Associated anomalies were detected exclusively after delivery and were missed on both types of prenatal imaging in 3.9% (8/205) of fetuses with prenatal diagnosis of isolated anomaly of the CC. Conclusion In fetuses with isolated anomaly of the CC diagnosed on antenatal neurosonography, MRI can identify a small proportion of additional anomalies, mainly malformations of cortical development, which are not detected on ultrasound. (c) 2021 International Society of Ultrasound in Obstetrics and Gynecology.
Published: 2021

48. The Approach to Pseudarthrosis After Adult Spinal Deformity Surgery: Is a Multiple-Rod Construct Necessary?

Author: Michael Dinizo, Tina Raman, Khaled Kebaish, Peter G. Passias, and Thomas J. Errico
Subjects: medicine.medical_specialty, business.industry, Biomechanics, Scoliosis, medicine.disease, Surgery, Pseudarthrosis, Fixation (surgical), medicine, Deformity, Spinal deformity, Orthopedics and Sports Medicine, Neurology (clinical), medicine.symptom, business
Abstract: Study Design: Retrospective study. Objectives: Our goal was to evaluate the rate of rod fracture and persistent pseudarthrosis in cohorts of patients treated with a dual rod or multiple-rod construct in revision surgery for pseudarthrosis. Methods: A dual rod construct was used in 23 patients, and a multiple rod construct in 24 patients, spanning the pseudarthrosis level. Two-year fusion grading, and rates of pseudarthrosis and implant failure, were assessed. Results: There were no differences in patient or surgical characteristics between the groups: (2- rod construct: Age 60 ± 14, Levels 10 ± 5, 3-column osteotomy:17%; multiple-rod construct: Age: 62 ± 11, Levels 9 ± 4, 3-column osteotomy:30%). Patients in the multiple rod construct were transfused a greater volume of packed red blood cells (pRBCs) intraoperatively (2.6 ± 2.9 vs. 1.1 ± 1.5 U, p < 0.0001). At 2 year follow up there was no difference in fusion grades at the previous level of pseudarthrosis, the rate of rod fracture or pseudarthrosis between the 2 groups, or rate of reoperation for pseudarthrosis, rod fracture, wound infection, hardware prominence, or PJK/PJF. Conclusions: Our data demonstrate no difference in fusion grade, or rates of rod fracture and revision at 2 years, after utilizing a dual rod versus multiple rod construct in revision surgery for pseudarthrosis. The low complication rates seen with either configuration warrant further investigation of the optimal instrumentation configuration.
Published: 2021
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49. Personalized therapeutic strategies in HER2-driven gastric cancer

Author: Daniel Moya-Rull, Annunziata Gloghini, Andrea Sartore-Bianchi, Salvatore Siena, Ivana Sarotto, Simonetta Guarrera, Sara Erika Bellomo, Stefania Manenti, Emanuele Rausa, Laura D'Errico, Ida Rapa, Sabrina Rizzolio, Uberto Fumagalli, Rossella Reddavid, Claudia Castelli, Caterina Marchiò, Carla Baronchelli, Tania Capeloa, Federica Morano, Simona Corso, Michele Sacco, Dario Ribero, Stefano De Pascale, Gian Luca Baiocchi, Federica Tosi, Maria Apicella, Salvatore Ribisi, Paola Cassoni, Maurizio Degiuli, Sarah Molfino, Giovanni Sgroi, Silvia Marsoni, Michele Prisciandaro, Stefania Durando, Cristina Migliore, Annalisa Petrelli, Antonino Sottile, Filippo Pietrantonio, Silvia Giordano, Alessandra Raimondi, Anna Sapino, Maria Bencivenga, and Stefano Ughetto
Subjects: Drug resistance, Gastric cancer, HER2, Targeted therapy, Trastuzumab, Oncology, Cancer Research, Immunoconjugates, Receptor, ErbB-2, medicine.medical_treatment, chemistry.chemical_compound, ErbB-2, Antineoplastic Agents, Immunological, 0302 clinical medicine, Surgical oncology, Antineoplastic Combined Chemotherapy Protocols, Prospective Studies, Enzyme Inhibitors, Precision Medicine, skin and connective tissue diseases, Gastroenterology, General Medicine, Protein-Tyrosine Kinases, Immunological, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Pertuzumab, Receptor, medicine.drug, medicine.medical_specialty, Antineoplastic Agents, Lapatinib, 03 medical and health sciences, Stomach Neoplasms, Internal medicine, medicine, Humans, neoplasms, business.industry, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Blockade, chemistry, Trastuzumab emtansine, business
Abstract: Trastuzumab is the only approved targeted therapy in patients with HER2-amplified metastatic gastric cancer (GC). Regrettably, in clinical practice, only a fraction of them achieves long-term benefit from trastuzumab-based upfront strategy. To advance precision oncology, we investigated the therapeutic efficacy of different HER2-targeted strategies, in HER2 “hyper”-amplified (≥ 8 copies) tumors. We undertook a prospective evaluation of HER2 targeting with monoclonal antibodies, tyrosine kinase inhibitors and antibody–drug conjugates, in a selected subgroup of HER2 “hyper”-amplified gastric patient-derived xenografts (PDXs), through the design of ad hoc preclinical trials. Despite the high level of HER2 amplification, trastuzumab elicited a partial response only in 2 out of 8 PDX models. The dual-HER2 blockade with trastuzumab plus either pertuzumab or lapatinib led to complete and durable responses in 5 (62.5%) out of 8 models, including one tumor bearing a concomitant HER2 mutation. In a resistant PDX harboring KRAS amplification, the novel antibody–drug conjugate trastuzumab deruxtecan (but not trastuzumab emtansine) overcame KRAS-mediated resistance. We also identified a HGF-mediated non-cell-autonomous mechanism of secondary resistance to anti-HER2 drugs, responsive to MET co-targeting. These preclinical randomized trials clearly indicate that in HER2-driven gastric tumors, a boosted HER2 therapeutic blockade is required for optimal efficacy, leading to complete and durable responses in most of the cases. Our results suggest that a selected subpopulation of HER2-“hyper”-amplified GC patients could strongly benefit from this strategy. Despite the negative results of clinical trials, the dual blockade should be reconsidered for patients with clearly HER2-addicted cancers.
Published: 2021
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50. Ganglionic Eminence Anomalies and Coexisting Cerebral Developmental Anomalies on Fetal MR Imaging: Multicenter-Based Review of 60 Cases

Author: Andrea Righini, M. Di Maurizio, Fabio Triulzi, Paul D. Griffiths, Andrea Rossi, Mariasavina Severino, Elisa Scola, Cecilia Parazzini, I. D'Errico, Lorenzo Pinelli, Giovanni Palumbo, and M. Scarabello
Subjects: Male, Hemimegalencephaly, Microcephaly, Ganglionic eminence, Unilateral polymicrogyria, Pediatrics, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, symbols.namesake, Fetus, 0302 clinical medicine, Pregnancy, Prenatal Diagnosis, medicine, Humans, Radiology, Nuclear Medicine and imaging, Fisher's exact test, Retrospective Studies, business.industry, Macrocephaly, Brain, Anatomy, medicine.disease, Magnetic Resonance Imaging, symbols, Female, sense organs, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, Ventriculomegaly
Abstract: BACKGROUND AND PURPOSE: The ganglionic eminences are transient fetal brain structures that produce a range of neuron types. Ganglionic eminence anomalies have been recognized on fetal MR imaging and anecdotally found in association with a number of neurodevelopmental anomalies. The aim of this exploratory study was to describe and analyze the associations between ganglionic eminence anomalies and coexisting neurodevelopmental anomalies. MATERIALS AND METHODS: This retrospective study includes cases of ganglionic eminence anomalies diagnosed on fetal MR imaging during a 20-year period from 7 centers in Italy and England. Inclusion criteria were cavitation or increased volume of ganglionic eminences on fetal MR imaging. The studies were analyzed for associated cerebral developmental anomalies: abnormal head size and ventriculomegaly, reduced opercularization or gyration, and abnormal transient layering of the developing brain mantle. The results were analyzed using χ(2) and Fisher exact tests. RESULTS: Sixty fetuses met the inclusion criteria (21 females, 24 males, 15 sex unknown). Thirty-four had ganglionic eminence cavitations (29 bilateral and 5 unilateral), and 26 had increased volume of the ganglionic eminences (19 bilateral, 7 unilateral). Bilateral ganglionic eminence cavitations were associated with microcephaly (P = .01), reduced opercularization, (P < .001), reduced gyration (P < .001), and cerebellar anomalies (P = .01). Unilateral ganglionic eminence cavitations were not significantly associated with any particular feature. Bilateral increased volume of the ganglionic eminences showed an association with macrocephaly (P = .03). Unilateral increased volume was associated with macrocephaly (P = .002), abnormal transient layering (P = .001), unilateral polymicrogyria (P = .001), and hemimegalencephaly (P < .001). CONCLUSIONS: Ganglionic eminence anomalies are associated with specific neurodevelopmental anomalies with ganglionic eminence cavitations and increased ganglionic eminence volume apparently having different associated abnormalities.
Published: 2021
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