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Objectives:Photo at Discharge (PaD) is a nurse-led discharge strategy for enhanced wound care information for patients and healthcare providers. The purpose of this study is to describe implementation of PaD in three English cardiac centres.Methods:A prospective, cross-sectional design was used to evaluate implementation fidelity and sustainability of PaD on various geographical settings.Results:Three out of four hospitals (75%) approached agreed to complete surveys on implementation fidelity. Implementing the IT component took an average of 16 months (range 11–21 months). Across the three sites, 474 nursing staff have received training on PaD. Since implementing, a combined total of 9007 patients have received PaD. A 1-month compliance snapshot indicated mean of 96% (range 92–100%).Conclusions:PaD requires collaborative working, a change in behaviour and a change to the service. Despite these challenges, fidelity and sustainability scores across the sites were high. The findings from this study may help to increase implementation quality and dissemination of PaD.

Restaurant management requires customer responsiveness to deal with increasingly higher expectations and market competitiveness. This study proposes an approach to simplify the decision-making process of restaurant managers by combining both live social media customer feedback and historical sales data in a sales forecast model (based on TripAdvisor data and the Bass model). Our approach was validated with internal and external (i.e., online reviews) data gathered from six restaurants. The collected data was processed using data analytics for developing a dashboard that provides value for restauranteurs by taking advantage of online reviews and sales forecast. Such dashboard was evaluated by restaurant management experts, which provided positive feedback, highlighting in particular the time saved in the decision-making process. info:eu-repo/semantics/acceptedVersion

etodologia Lean Startup como forma de melhoria no processo de criação e desenvolvimento de novos produtos e serviços. Foi realizada uma revisão bibliográfica sobre Startup, Lean e Lean Startup. A pesquisa caracterizou-se como bibliográfica, trazendo um exemplo da utilização da metodologia Lean Startup

BackgroundExperiencing a pandemic can be very unsettling and may have a negative impact on the mental health of frontline healthcare workers (HCWs). This may have serious consequences for the overall well-being of HCWs, which in turn may adversely affect patient safety and the productivity of the institution.AimsWe designed a study to assess the prevalence of generalised anxiety disorder (GAD), depression and work-related stress experienced by the National Health Service staff in a large tertiary London hospital treating patients with COVID-19 during the current active phase of the COVID-19 era.MethodsAn anonymous survey was designed with demographic data and three questionnaires. The Generalised Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 were used to assess anxiety and depression, respectively. The Health and Safety Executive Management Standards Indicator Tool was used to assess work-related stress. Staff from multiple specialties embracing cardiothoracic surgery, cardiology, respiratory medicine, endocrinology, oncology, imaging, anaesthesia and intensive care at our hospital were asked to complete the questionnaire between 25 May and 15 June 2020.ResultsA total of 302 staff members (106 males and 196 females) completed the survey. The overall prevalence of GAD and depression was 41.4% and 42.7%, respectively. The prevalence of GAD and depression was significantly higher in females than in males and was statistically significant. Nurses were four times more likely to report moderate to severe levels of anxiety and depression as compared with doctors. Work-related stress was also observed to be prevalent in our surveyed population with the following standards: relationships, role, control and change showing a need for improvement.ConclusionsOur study presents early evidence suggestive of a high prevalence of GAD, depression and work-related stress in HCWs. It is imperative that coherent strategies are implemented to improve the healthcare work environment during this pandemic and mitigate further injury to the mental health status of the healthcare population.

Objective: to evaluate the adherence to the checklist procedure in surgeries performed in a public teaching hospital and to identify the patient’s profile regarding its use. Method: a descriptive study methodology was performed, which was conducted at the surgical ward of the Hospital Universitario de Londrina-PR from August to December 2014. Four hundred perioperative verification instruments were analyzed. Results: there was a predominance of male patients (55.5%), aged 21–40 years, and the predominant medical specialty was orthopedics. After 5 years of implementation and a second reformulation of the checklist, there was a considerable decrease in the number of unfilled instruments (blank), but there was an increase in the number of incomplete instruments. Conclusion: the adherence to the checklist needs to be improved to contribute to the reduction of adverse events, which may affect surgical patients and is a challenge for institutions and their staff.

Objetivo Comparar la frecuencia de los principales factores clínicos, bioquímicos y antropométricos de riesgo cardiovascular entre una comunidad rural y una urbana de Tinaquillo, Venezuela.Métodos Se evaluaron 118 individuos mayores de 18 años (52 pertenecientes a la comunidad urbana y 66 a la comunidad rural) a los cuales se les determinó peso, talla, circunferencia abdominal, presión arterial, glicemia y perfil lipídico. Se aplicó una encuesta para medir antecedentes personales de enfermedad cardiovascular y estilo de vida.Resultados Se evidenció que alrededor del 60 % de los individuos de la comunidad rural presentaron entre obesidad y sobrepeso. Cifras similares fueron obtenidas en la comunidad urbana, no encontrándose diferencias estadísticamente significativas entre ambas. Casi la mitad de los participantes mostró obesidad abdominal, así como una frecuencia importante de individuos con HDLc bajo (mayor al 70 %). Cabe destacar que si bien, se obtuvieron bajos porcentajes de hipertrigliceridemia, los mismos fueron significativamente superiores en la comunidad rural (Chi-cuadrado=4,82; p=0,0281). Caso contrario ocurre con la frecuencia del hábito tabáquico, el cual es estadísticamente superior en la comunidad urbana (Chi-cuadrado=4,48; p=0,0342).Conclusión Los resultados muestran una elevada frecuencia de factores de riesgo cardiovascular en ambas comunidades. En consecuencia, los programas de promoción en salud emergentes deben tener alcance hasta las comunidades rurales, pues el riesgo a padecer una enfermedad cardiovascular es similar al de la comunidad urbana, además de estar igualmente propensas a la adquisición de hábitos no saludables. Objective To compare the frequency of major clinical, biochemical and anthropometric cardiovascular risk factors between a rural community and an urban community from Tinaquillo, Venezuela. Method 118 individuals older than 18 years (52 of the urban community and 66 of the rural community) were included; their weight, height, waist circumference, blood pressure, blood glucose and lipid profile were assessed. A survey to measure personal history of cardiovascular disease and lifestyle was applied.Results About 60 % of the individuals of the rural community were either obese or overweight; similar figures were obtained in the urban community with no statistically significant differences. Almost half of the participants had abdominal obesity, and also a significant frequency of individuals with low HDLc (greater than 70 %) was observed. It should be noted that although low percentages of hypertriglyceridemia were obtained, they were significantly higher in the rural community (chi-square=4.82, p=0.0281). The opposite occurs with the frequency of smoking, which is statistically higher in the urban community (chi-square=4.48, p=0.0342).Conclusions The results show a high prevalence of cardiovascular risk factors in both communities. Consequently, health promotion programs should reach out to rural communities, as the risk of cardiovascular disease is similar to that of the urban community, who are equally prone to acquire unhealthy habits.

BACKGROUND: Pressure ulcers represent a serious public health problem, serving as a quality indicator (negative) the assistance provided by the health services. The aim of this study was to identify the prevalence of pressure ulcers in the Intensive Care Unit of a University Hospital in Joao Pessoa-PB and check the associations between socio-demographic and clinical data of customers and risk factors for the development of these. METHODS: The study of the sectional, quantitative, carried out with 78 patients in the Intensive Care Unit of a University Hospital in Joao Pessoa. Data were collected from medical record information from January to December 2014. RESULTS: Ten patients had pressure ulcers, and 6 already admitted with injuries and the 4 developed during hospitalization in the studied sector. The prevalence of these lesions in the sample was 12.8%. Has been identified as risk factors associated with pressure ulcer (p

O desenvolvimento de úlcera por pressão é um evento adverso indesejável com incidência alta e estável ao longo do tempo. A presença deste evento acarreta dor, desconforto e aumento de morbimortalidade para as pessoas portadoras desse tipo de lesão, além do custo elevado nos diferentes serviços de saúde envolvidos no tratamento do evento. Na presente pesquisa, o foco de investigação da problemática foi o paciente cirúrgico. Assim, o objetivo geral do estudo foi analisar o risco de desenvolvimento, fatores de risco e a incidência de úlcera por pressão em pacientes submetidos a cirurgias eletivas de porte II, III e IV. Para tal adotamos a abordagem metodológica quantitativa, delineamento de pesquisa não experimental, tipo de estudo correlacional, prospectivo. A amostra foi composta por 148 pacientes adultos, de ambos os sexos, submetidos a cirurgias ortopédicas, neurológicas, do aparelho digestivo, urológicas, cardiovasculares e de obesidade mórbida. Em relação ao risco de desenvolvimento de úlcera por pressão, o qual foi mensurado por meio da aplicação da Escala de Braden, os pacientes que não desenvolveram esse tipo de lesão apresentaram na primeira avaliação um escore total médio de 20,12, que decresceu na segunda avaliação para uma média de 16,16. Para esse grupo o escore total mais frequente foi de 22, na primeira avaliação, o que classifica esse grupo como sem risco para o desenvolvimento de UP no pré operatório. Para o grupo que desenvolveu as lesões, a média do escore total da Escala de Braden, na primeira avaliação, foi de 15,81, caindo para 11,73, na segunda avaliação, sendo que para este grupo o escore total mais frequente na primeira avaliação foi de 18. Assim este grupo pode ser classificado, no pré operatório, de baixo risco para o desenvolvimento de úlcera por pressão. Na amostra estudada, a incidência de úlcera por pressão foi de 25%; as áreas corporais mais acometidas pelas lesões foram a região sacro/glútea (68%), calcâneos (18%), região dorsal (9%) e o pavilhão auricular (5%). A maioria das lesões diagnosticadas foi de grau II (57%), seguida por lesões de grau I (41%) e grau III (2%). Na amostra investigada nenhuma lesão de grau IV foi detectada. No modelo de regressão linear binominal empregado, as variáveis preditoras para o desenvolvimento de úlcera por pressão foram o tempo de anestesia e o porte cirúrgico quando investigadas em associação com outras variáveis relacionadas ao procedimento anestésico cirúrgico. Em relação às variáveis clínicas do paciente estudadas, a classificação ASA e a presença de hipertensão arterial foram preditoras para o desenvolvimento de úlcera por pressão quando investigadas em associação com outras variáveis. No modelo de regressão logística binária, as variáveis preditoras para desenvolvimento de úlcera por pressão foram idade, sexo e o tempo de anestesia quando estudadas em associação com outras variáveis. A presente investigação buscou dar o primeiro passo para o desenvolvimento de uma proposta de organização da avaliação do desenvolvimento de úlcera por pressão no paciente cirúrgico, a qual é simples e fácil de ser aplicada pelo enfermeiro no perioperatório. The development of pressure ulcer (PU) is an adverse unwelcome event with high and stable incidence throughout time. The presence of such event results in pain, discomfort, and increase of morbi-mortality in people bearing this type of lesion, besides the high costs of different health services related to the event\'s treatment. In the present research, the investigation focus of the problematic was on the surgical patient, thus the general objective of the study was analyzing the risk of development, risk factors, and the incidence of pressure ulcer in patients submitted to elective surgeries of size II, III and IV. Having that in mind, it was adopted the quantitative methodological approach, non-experimental research outlining, a type of correlational, prospective study. The sample was composed of 148 adult patients, of both genders, submitted to orthopedic, neurological, of the digestive tract, urological, cardiovascular, and morbid obesity surgeries. Concerning the risk of pressure ulcer development, which was measured through the application of Braden Scale, the patients who did not develop such type of lesion exhibited, in their first evaluation, a total average score of 20.12 that decreased in the second evaluation to an average of 16.16. For that group, the most frequent total score was of 22, in their first evaluation, fact that classifies such group as a non-risk one for the development of PU in pre-operatory period. For the group that developed the lesions, Braden Scale\'s total average score, in the first evaluation, was of 15,81 falling to 11,73 in the second evaluation, whereas in this group the most frequent total score in the first evaluation was of 18. Therefore, this group could be classified, in pre-operatory period, as of low risk for the development of pressure ulcer. In the studied sample, the incidence of pressure ulcer was of 25%; the body areas mostly affected by lesions were the sacral/gluteal area (68%), calcaneus (18%), dorsal region (9%), and the auricular pavilion (5%). Most diagnosed lesions were of grade II (57%), followed by lesions of grade I (41%) and grade III (2%). In the investigated sample, no grade IV lesion was detected. Under the employed model of binominal linear regression, the predicting variables for the development of pressure ulcer were anesthesia time and the surgical size when investigated in association with other variables related to the surgical anesthetic procedure. Concerning the patient\'s clinical variables studied, the classification ASA and the presence of hypertension were predictors for the development of pressure ulcer when investigated in association with other variables. In the binary logistic regression model, the predicting variables form the development of pressure ulcer were age, gender, and the anesthesia time when studied in association with other variables. The present investigation sought to give the first step towards the development of a proposition for the organization of the pressure ulcer development evaluation in the surgical patient, which is simple and easy to be applied by the nurse during the perioperative period.

Introducción. La distribución y el almacenamiento del agua después de su potabilización, pueden originar cambios significativos en su calidad, por lo que es necesario conocer las características finales del agua domiciliaria que consumen los usuarios. Objetivo. Evaluar de forma preliminar las sustancias químicas tóxicas en el agua de tanques y grifos de viviendas abastecidas por el acueducto de Bogotá. Materiales y métodos. Se hizo un estudio descriptivo en 26 viviendas localizadas en Bogotá y Soacha. Se hicieron dos muestreos: uno en época de lluvias y otro en temporada seca, y en ambos se aplicó una encuesta y se recolectaron muestras de agua de los tanques de almacenamiento y los grifos. Las muestras se sometieron a ensayos fisicoquímicos básicos, a una prueba de tamización de sustancias orgánicas e inorgánicas, y a pruebas de determinación de metales pesados y de residuos de plaguicidas organofosforados y carbamatos. Resultados. La conductividad, el color y los nitratos presentaron valores permisibles; el pH y la turbiedad tuvieron una ligera tendencia a presentar niveles altos y, el cloro residual, niveles bajos. Hubo trazas de aluminio en el 94 % de las muestras. En el período seco, 8 % de las muestras presentó compuestos orgánicos y, en el período lluvioso, 66,7 %. Solo hubo un resultado positivo para las sustancias inorgánicas. En el 11,5 % de las viviendas, el nivel de riesgo fue medio, en el 61,5 %, bajo, y en el 27 % no se registró riesgo. Conclusiones. Se evidenció deterioro de la calidad del agua domiciliaria debido a la presencia de sustancias orgánicas en tanques y sobre todo en las redes, presumiblemente a causa de la formación de biopelículas o a la presencia de polímeros orgánicos. Los niveles de aluminio cercanos al máximo aceptable pueden explicarse por los remanentes de los coagulantes utilizados durante el tratamiento.

Colorectal distention is a non-invasive stimulus used to study visceral pain processing in the nervous system. In this study, immunocytochemical labeling for the immediate-early gene, c-Fos, was used to map limbic brain structures involved in processing visceral pain. Rats received noxious colorectal distention while loosely restrained or loose restraint without distention (control). The brains were immunostained and the density of Fos-labeled nuclei within areas of the brain associated with limbic function were examined. Many cortical (cingulate; retrosplenial; insular; perirhinal, entorhinal) and subcortical (periaqueductal gray; locus coeruleus; lateral parabrachial area; paraventricular, anterodorsal and centromedian thalamic nuclei; lateral septal area; dorsomedial hypothalamus; cortical amygdala; subiculum) areas were labeled in the control rats, but significantly more Fos was observed in these areas following noxious colorectal distention (CRD). Additional areas were labeled following CRD but not restraint (e.g. infralimbic and prelimbic cortices; mediodorsal thalamic nucleus; central amygdaloid nucleus). The results show that noxious visceral stimuli result in Fos expression in limbic structures that exceeds that induced by restraint stress, suggesting that different pathways and circuits are recruited by stimuli which can produce similar emotional responses.

The lack of reproducibility of preclinical research is a significant and growing problem which slows basic research and leads to fruitless clinical trials. An increasing number of reports have found discrepancies in published preclinical studies across scientific disciplines. For example: * Amgen found that 47 of 53 “landmark” oncology publications could not be reproduced. * Bayer found that their internal results contradicted academic publications in 43 of 67 oncology and cardiovascular projects. * Dr. John Ioannidis and his colleagues found that of 432 publications purporting sex differences in hypertension, multiple sclerosis, or lung cancer, only one data set was reproducible. These studies, and the many others that report similar results, highlight a significant problem in the development of new therapies to treat disease. With increasing reports of discrepancies in preclinical publications, pharmaceutical companies are being forced to re-evaluate their reliance on academic research. In fact, Bayer recently decided to halt nearly two-thirds of target-validation projects.In this session, we'll report the work we have done to address this issue. We will bring together researchers and representatives from funders and publishers to discuss the issue of reproducibility. We will share funder and publisher initiatives to promote reproducibility and also discuss research practices that lead to more reproducible research such as using proper statistical tests, reporting all experimental data, experimental blinding, and identification and validation of research reagents. We'll also share preliminary results from an Arnold Foundation-funded study to replicate the 50 most high impact cancer biology studies from 2010-1012. Reproducibility ResearchAmgen47 of 53 “landmark” oncology publications could not be reproducedBayerinternal results contradicted academic publications in 43 of 67 oncology and cardiovascular projectsDr. John Ioannidis and colleagues432 publications purporting sex differences in hypertension, multiple sclerosis, or lung cancer, only one data set was reproducible Note: This abstract was not presented at the meeting. Citation Format: Gunn William, Elizabeth Iorns, Elizabeth Silva, Brian Nosek. Preliminary results from the Reproducibility Project: Cancer Biology - a replication of 50 high-impact cancer cell biology papers from 2010-2012. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5053. doi:10.1158/1538-7445.AM2014-5053

Introducción. Por ser los plaguicidas anticolinesterásicos una causa importante de intoxicación y de muerte por intoxicación en los países en vía de desarrollo, el Instituto Nacional de Salud implementó el Programa de Vigilancia Epidemiológica de Organofosforados y Carbamatos, del cual, este informe corresponde al período 2002-2005. Objetivo. Determinar la actividad de la acetilcolinesterasa en participantes con riesgo de exposición a plaguicidas organofosforados y carbamatos, e identificar los plaguicidas más utilizados en el área estudiada. Materiales y métodos. Es un estudio descriptivo de información reportada al Programa de Vigilancia Epidemiológica de Organofosforados y Carbamatos por once departamentos colombianos, los cuales realizaron la determinación de acetilcolinesterasa con el equipo Lovibond. Resultados. Participaron 28.303 personas con riesgo de exposición a plaguicidas; 81,4% eran hombres. El 9,3% de las determinaciones analíticas fueron anormales, con una prevalencia de anormalidad entre los hombres de 9,9% y de 7,0% en las mujeres. Presentaron mayor prevalencia de valores anormales los grupos de edad de 18 a 25 años (12,3%) y de 0 a 5 años (10,7%), y los oficios de jornalero (27,0%) y servicios generales del campo (26,1%). De los 975 participantes, en el departamento del Meta, 80% de los participantes presentaron niveles anormales de actividad de la enzima. Los plaguicidas más reportados fueron los organofosforados (39,7%) y carbamatos (16,6%). Conclusión. El incremento en la prevalencia de valores anormales de la acetilcolinesterasa y el riesgo de exposición infantil, hacen necesario disminuir el uso y la comercialización de plaguicidas de alto riesgo, y utilizar métodos menos tóxicos para el control de plagas.

The objectives of this study were to determine arginine and glutamate levels in the gingival crevicular fluid (GCF) of adult chronic periodontitis patients versus periodontally healthy controls, and to compare two kinds of microdialysis probes: normal and U-shaped probes. The analysis of GCF components was developed to improve the diagnosis of periodontal disease (PD). Proteolysis in the periodontal tissues increases the concentration of amino acids (aa) in the GCF and the levels of these aa may reveal PD features and stages. GCF samples were collected by microdialysis in situ from 5 periodontally affected sites (probing depth >5 mm, clinical attachment loss >3 mm) in 14 adult chronic periodontitis patients and from 14 adult periodontally healthy controls. Capillary zone electrophoresis coupled to laser induced fluorescence detection was used to measure concentration of arginine and glutamate in the GCF. Data were analyzed statistically by ANOVA and Tukey's post-hoc tests (?=0.05). Arginine concentration was increased (p5 mm, perda da inserção clínica >3 mm) em 14 pacientes adultos com periodontite crônica e 14 controles saudáveis. Para medir a concentração de arginina e glutamato no GFC, usou-se a técnica de eletroforese capilar com detecção de fluorescência induzida por laser. Nos pacientes com periodontite crônica, a concentração de arginina aumentou significantemente (p