Author: "Du, Fang" / Topic: business.industry - Searchworks@Jio Institute Digital Library Search Results

30 results on '"Du, Fang"'

1. Excessive fat expenditure in cachexia is associated with dysregulated circadian rhythm: a review

Author: Yongcheng Wang, Lu Cai, Yong Wang, Du-Fang Ma, and Xiao Li
Subjects: medicine.medical_specialty, Cachexia, RC620-627, Endocrinology, Diabetes and Metabolism, Circadian clock, Medicine (miscellaneous), Adipose tissue, Review, White adipose tissue, Brown adipose tissue, Internal medicine, medicine, TX341-641, Circadian rhythm, Nutritional diseases. Deficiency diseases, Inflammation, Nutrition and Dietetics, Nutrition. Foods and food supply, business.industry, Adipose tissue expenditure, Lipid metabolism, medicine.disease, medicine.anatomical_structure, Endocrinology, business, Thermogenesis
Abstract: Cachexia is a progressive metabolic disorder characterized by the excessive depletion of adipose tissue. This hypermetabolic condition has catastrophic impacts on the survival and quality of life for patients suffering from critical illness. However, efficient therapies to prevent adipose expenditure have not been discovered. It has been established that the circadian clock plays an important role in modulating fat metabolic processes. Recently, an increasing number of studies had provided evidence showing that disrupted circadian rhythm leads to insulin resistance and obesity; however, studies analyzing the relationship between circadian misalignment and adipose tissue expenditure in cachexia are scarce. In the present review, we cover the involvement of the circadian clocks in the regulation of adipogenesis, lipid metabolism and thermogenesis as well as inflammation in white and brown adipose tissue. According to the present review, we conclude that circadian clock disruption is associated with lipid metabolism imbalance and elevated adipose tissue inflammation. Moreover, under cachexia conditions, lipid synthesis and storage processes lost rhythm and decreased, while lipolysis and thermogenesis activities remained high for 24 h. Therefore, disordered circadian clock may be responsible for fat expenditure in cachexia by adversely influencing lipid synthesis/ storage/lipolysis/utilization. Further study needs to be performed to explore the direct interaction between circadian clock and fat expenditure in cachexia, it will likely provide potential efficient drugs for the treatment of fat expenditure in cachexia.
Published: 2021
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2. Serum levels of homocysteine and circulating antioxidants associated with heart rate variability in patients with unstable angina pectoris

Author: Yong-Cheng Wang, Du-Fang Ma, Ping Jiang, Jin-Long Yang, Yi-Mei Zhang, Xiao Li, and Ning-Ning Wang
Subjects: Male, medicine.medical_specialty, Homocysteine, lcsh:Medicine, Antioxidants, Angina, chemistry.chemical_compound, Heart Rate, Internal medicine, Correspondence, medicine, Humans, Heart rate variability, In patient, Angina, Unstable, Aged, business.industry, Unstable angina, lcsh:R, General Medicine, Middle Aged, medicine.disease, chemistry, Cardiology, Female, business
Published: 2019
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3. Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation

Author: Yi-Mei Zhang, Du-Fang Ma, Yongcheng Wang, Xiao Li, Feng Dong, Yue-Hua Jiang, Guofeng Zhou, Jinlong Yang, Hengyi Zhao, Ping Jiang, and Zhao-Yu Li
Subjects: Cardiac function curve, medicine.medical_specialty, Article Subject, medicine.drug_class, 030204 cardiovascular system & hematology, 03 medical and health sciences, Other systems of medicine, 0302 clinical medicine, Internal medicine, medicine, Natriuretic peptide, 030304 developmental biology, 0303 health sciences, Ejection fraction, Tyrosine hydroxylase, business.industry, medicine.disease, Choline acetyltransferase, Endocrinology, Blood pressure, Nerve growth factor, Complementary and alternative medicine, Heart failure, business, RZ201-999, Research Article
Abstract: Objective. The anatomical and functional imbalances of sympathetic nerves are associated with cardiovascular disease progression. Xiao-Qing-Long-Tang (XQLT), an ancient Chinese herbal formula, has been used to treat cardiovascular diseases in eastern Asia for thousands of years. We determined the effect of XQLT in maintaining cardiac function during heart failure with reduced ejection fraction (HFrEF) with respect to its neurobiological effects in salt-sensitive rats. Methods. Dahl salt-sensitive (DS) rats were fed a high-salt diet to establish an HFrEF model and were divided into model (DS, administered normal saline) and XQL groups (administrated XQLT) randomly, with SS-13BN rats being used as the control. The bodyweight and blood pressure of rats were observed regularly. Electrocardiogram, echocardiography, and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) were determined to assess cardiac function. The sympathetic tune and myocardial morphological changes were evaluated. Western blot and qRT-PCR were used to assay the expression of the nerve growth factor (NGF) and leukemia inhibitory factor (LIF). Tyrosine hydroxylase (TH), choline acetyltransferase (CHAT), and growth-associated protein 43 (GAP43) were assayed to confirm sympathetic remodeling. The micromorphological changes in cardiac sympathetic nerve endings were observed by transmission electron microscopy. Results. Four weeks after XQLT treatment, cardiac function and bodyweight were higher and blood pressure was lower than that of the DS group. Myocardial noradrenaline (NA) increased, while the plasma NA level decreased significantly. The morphology demonstrated that XQLT significantly alleviated myocardial damage. XQLT decreased the expression of LIF, increased the expression of NGF, enhanced the TH+/GAP43+ and TH+/CHAT + positive nerve fiber density, and improved the TH and GAP43 protein expression, but had no effect on CHAT. Moreover, XQLT improved the micromorphology of sympathetic nerve endings in the myocardium. Conclusion. XQLT maintains cardiac function during HFrEF in salt-sensitive rats, in part, by regulating the imbalance of cardiac sympathetic innervation.
Published: 2020

4. Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota

Author: Jiye Chen, Yongcheng Wang, Guofeng Zhou, Jinlong Yang, Xiao-wei Han, Du-Fang Ma, Zhao-Yu Li, Yue-Hua Jiang, Xiao Li, and Chen-Yu Chi
Subjects: 0301 basic medicine, Male, Article Subject, lcsh:Medicine, Physiology, Administration, Oral, Inflammation, Cardiomegaly, 030204 cardiovascular system & hematology, Gut flora, digestive system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Immune system, fluids and secretions, Oral administration, Fibrosis, medicine, Animals, Myocytes, Cardiac, Feces, Heart Failure, Rats, Inbred Dahl, General Immunology and Microbiology, biology, business.industry, lcsh:R, Stroke Volume, General Medicine, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, Rats, stomatognathic diseases, Disease Models, Animal, 030104 developmental biology, Blood pressure, Heart failure, medicine.symptom, business, Research Article, Drugs, Chinese Herbal
Abstract: Background. Changes in the gut microbiota are associated with cardiovascular disease progression. Xiao-Qing-Long Tang (XQLT), a traditional herbal formula, has an anti-inflammatory effect and regulates the steady state of the immune system, which is also associated with the progression of heart failure with preserved ejection faction (HFpEF). In this study, we investigated whether XQLT could contribute to prevent the development of HFpEF and whether the modulation of the gut microbiota by this herbal formula could be involved in such effect. Methods. The gut microbiota, SCFAs, the histology/function of the heart, and systolic blood pressure were examined to evaluate the effect of XQLT on the gut microbiota and the progression of HFpEF after oral administration of XQLT to model rats. Furthermore, we evaluated, through fecal microbiota transplantation experiments, whether the favorable effects of XQLT could be mediated by the gut microbiota. Results. Oral administration of XQLT contributed to the reduction of elevated blood pressure, inflammation, and compensatory hypertrophy, features that are associated with the progression of HFpEF. The gut microbiota composition, SCFA levels, and intestinal mucosal histology were improved after treatment with XQLT. Moreover, fecal transfer from XQLT-treated rats was sufficient to prevent the progression of HFpEF. Conclusions. These data suggested that XQLT prevented the development of HFpEF in model rats by regulating the composition of the gut microbiota.
Published: 2019

5. Guizhi Decoction () Inhibits Cholinergic Transdifferentiation by Regulating Imbalance of NGF and LIF in Salt-Sensitive Hypertensive Heart Failure Rats

Author: Jinlong Yang, Ping Jiang, Xiao Li, Zhao-Yu Li, Yi-Mei Zhang, Guofeng Zhou, Du-Fang Ma, and Yongcheng Wang
Subjects: Cardiac function curve, medicine.medical_specialty, 0211 other engineering and technologies, 02 engineering and technology, 030226 pharmacology & pharmacy, Leukemia Inhibitory Factor, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, 021105 building & construction, Nerve Growth Factor, medicine, Animals, Pharmacology (medical), Decompensation, Denervation, Heart Failure, Rats, Inbred Dahl, business.industry, Heart, General Medicine, medicine.disease, Choline acetyltransferase, Rats, Endocrinology, Nerve growth factor, Complementary and alternative medicine, Heart failure, Cell Transdifferentiation, Cholinergic, business, Leukemia inhibitory factor, Drugs, Chinese Herbal
Abstract: To observe the imbalance of anatomical and functional innervation factors of sympathetic nerves, nerve growth factor (NGF) and leukemia inhibitory factor (LIF), in salt-sensitive hypertensive heart failure rats and to explore the effects of treatment with Guizhi Decoction (桂枝汤) on sympathetic remodeling by inhibiting cholinergic transdifferentiation. SS-13BN and Dahl salt-sensitive (DS) rats were divided into 3 groups: SS-13BN group (control group, n=9), DS group (model group, n=9) and GS group (Guizhi Decoction, n=9). After 10 weeks of a high-salt diet, the GS group rats were given Guizhi Decoction and other two groups were given saline at an equal volume as a vehicle. After 4 weeks’ intragastric administration, rats were executed to detect the relevant indicators. Echocardiography and plasma n-terminal pro-B type natriuretic peptide (NT-proBNP) levels were used to assess cardiac function. Noradrenaline (NA) levels in the plasma and myocardium were detected to evaluate the sympathetic function. NGF and LIF expression were detected in the myocardium by Western blot or quantitative real-time PCR. Double immunofluorescence or Western blot was used to detect tyrosine hydroxylase (TH), choline acetyltransferase (CHAT) and growth associated protein 43 (GAP43) in order to reflect anatomical and functional changes of sympathetic nerves. DS group had anatomical and functional deterioration of sympathetic nerves in the decompensation period of heart failure compared with SS-13BN group. Compared with the DS group, Guizhi Decoction significantly decreased the expression of LIF mRNA/protein (P 0.05). Guizhi Decoction inhibited inflammatory infiltration and collagen deposition of myocardial injury, increased the content of myocardial NA (P
Published: 2019

6. N-Terminal Pro-B-Type Natriuretic Peptide Levels Inversely Correlated With Heart Rate Variability in Patients With Unstable Angina Pectoris

Author: Ma Du-Fang, Jiang Ping, Li Xiao, Yin Yonghui, and Wang Yongcheng
Subjects: Male, medicine.medical_specialty, medicine.drug_class, Statistics as Topic, 030204 cardiovascular system & hematology, Risk Assessment, Angina, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Heart Rate, Internal medicine, Natriuretic Peptide, Brain, Heart rate, medicine, Natriuretic peptide, Humans, Heart rate variability, In patient, Angina, Unstable, cardiovascular diseases, Aged, medicine.diagnostic_test, business.industry, Unstable angina, Reproducibility of Results, General Medicine, Middle Aged, Prognosis, medicine.disease, Peptide Fragments, Autonomic nervous system, 030220 oncology & carcinogenesis, Electrocardiography, Ambulatory, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Electrocardiography, circulatory and respiratory physiology
Abstract: We explored the relationships between heart rate variability (HRV) and levels of N-terminal Pro-B-type natriuretic peptide (NT-proBNP) in patients with unstable angina pectoris (UA).A total of 90 consecutive patients admitted48 hours for UA were included. Serum levels of NT-proBNP were measured from blood samples. The cohort was divided into tertiles according to NT-proBNP levels. HRV parameters including SDNN, RMSSD, LF, HF, TP, and VLF were assessed by 24-hour Holter ECG monitoring.The median (IQR) NT-proBNP level was 177.02 (64.76, 740.70) pg/mL. Patients with SDNN100 ms had higher levels of NT-proBNP than those with SDNN100 ms (P = 0.003). With increasing levels of NT-proBNP, both the 24hour monitoring HRV and night-monitoring HRV showed that SDNN and VLF gradually decreased (P0.01), and patients in the NT-proBNP lowest tertile group had higher LF values than the other two groups (P0.05); however, no difference was found in RMSSD, HF, and TP. During the daytime, the LF, VLF, and TP values were lower in the NTproBNP highest group compared with the lowest tertile group (P0.05). NT-proBNP levels correlated negatively with SDNN (r = -0.314, P = 0.003) and VLF (r = -0.397, P0.001) but not with other HRV parameters. Multiple regression analysis showed that serum levels of NT-proBNP remained predictive of SDNN (β = -0.060, P = 0.001) and VLF (β = -0.145, P0.001), even after adjustment for confounders.Our study showed that the elevated serum levels of NT-proBNP predict reduced HRV parameters, and the increased NT-proBNP levels combined with decreased HRV represent the degree of neurohormonal dysfunction and may be better prognostic predictors for risk stratification in UA patients.
Published: 2016
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7. Effect of Guizhi Decoction (桂枝汤) on heart rate variability and regulation of cardiac autonomic nervous imbalance in diabetes mellitus rats

Author: Du-Fang Ma, Jinlong Yang, Xiao Li, Yue-Hua Jiang, Chuan-Hua Yang, and Ping Jiang
Subjects: Male, medicine.medical_specialty, Tyrosine 3-Monooxygenase, Traditional Chinese medicine, Autonomic Nervous System, Choline O-Acetyltransferase, Diabetes Mellitus, Experimental, Diabetic Neuropathies, Heart Rate, Diabetes mellitus, Internal medicine, Animals, Telemetry, Medicine, Heart rate variability, Pharmacology (medical), Rats, Wistar, Guizhi decoction, Monitoring, Physiologic, business.industry, food and beverages, Heart, Vagus Nerve, Cardiac autonomic neuropathy, General Medicine, medicine.disease, Disease Models, Animal, Treatment Outcome, Complementary and alternative medicine, Anesthesia, Medicine public health, Cardiology, business, Drugs, Chinese Herbal
Abstract: To observe abnormalities in heart rate variability (HRV) in diabetic rats and to explore the effects of treatment with Guizhi Decoction ([symbols; see text]) on cardiac autonomic nervous (CAN) imbalance.A radio-telemetry system for monitoring physiological parameters was implanted into rats to record electrocardiac signals and all indictors of HRV [time domain measures: standard deviation of all RR intervals in 24 h (SDNN), root mean square of successive differences (RMSSD), percentage of differences between adjacent RR intervals greater than 50 ms (PNN50), and standard deviation of the averages of RR intervals (SDANN); frequency domain measures: low frequency (LF), high frequency (HF), total power (TP), and LF/HF ratio]. The normal group was randomly selected, and the remaining rats were used to establish streptozocin (STZ)-induced diabetic model. After 4 weeks, the model rats were divided into the model group, the methycobal group, and the Guizhi Decoction group, 9 rats in each group. Four weeks after intragastric administration of the corresponding drugs, the right atria of the rats were collected for immunohistochemical staining of tyrosine hydroxylase (TH) and choline acetyltransferase (CHAT) to observe the distribution of the sympathetic and vagus nerves in the right atrium. The myocardial homogenate from the interventricular septum and the left ventricle was used for determination of TH, CHAT, growth-associated protein 43 (GAP-43), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF) levels using an enzyme-linked immunosorbent assay.(1) STZ rats had elevated blood glucose levels, reduced body weight, and decreased heart rate; there was no difference between the model group and the drug treated groups. (2) Compared with the model group, only RMSSD and TP increased in the methycobal group significantly (P0.05); SDNN, RMSSD, PNN50, LF, HF, and TP increased, LF/HF decreased (P0.05), and SDANN just showed a decreasing trend in the Guizhi Decoction group (P0.05). TH increased, CHAT decreased, and TH/CHAT increased in the myocardial homogenate of the model group (P0.05). Compared with the model group, left ventricular TH reduced in the methycobal group; and in the Guizhi Decoction group CHAT increased, while TH and TH/CHAT decreased (P0.05). Compared with the model group, CNTF in the interventricular septum increased in the methycobal group (P0.05); GAP-43 increased, NGF decreased, and CNTF increased (P0.05) in the Guizhi Decoction group. There were significant differences in the reduction of NGF and elevation of CNTF between the Guizhi Decoction group and the methycobal group (P0.05). (3) Immunohistochemical results showed that TH expression significantly increased and CHAT expression significantly decreased in the myocardia of the model group, whereas TH expression decreased and CHAT expression increased in the Guizhi Decoction group (P0.05).Guizhi Decoction was effective in improving the function of the vagus nerve, and it could alleviate autonomic nerve damage.
Published: 2014
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8. Hypothermia attenuates protective effects of ginkgolides on astrocytes from ischemia/reperfusion injury

Author: Qian Zhong Ming, Ke Ya, Wu Xiao Mei, Du Fang, and Zhu Li
Subjects: Pathology, medicine.medical_specialty, Time Factors, Cell Survival, Ischemia, Apoptosis, Pharmacology, Neuroprotection, Brain Ischemia, Mice, Cellular and Molecular Neuroscience, Hypothermia, Induced, medicine, Animals, Ginkgolides, Cells, Cultured, Mice, Inbred ICR, Dose-Response Relationship, Drug, business.industry, Brain, Cell Biology, Hypothermia, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Neuroprotective Agents, medicine.anatomical_structure, Animals, Newborn, Astrocytes, Reperfusion Injury, Neuroglia, medicine.symptom, business, Reperfusion injury, Astrocyte
Abstract: The neuroprotective roles of both hypothermia and ginkgolides have been well confirmed. We first examined whether hypothermia (32 or 28 degrees C) or ginkgolides have a protective effect on astrocytes against ischemia and reperfusion-induced injury. We demonstrated that ginkgolides, but not hypothermia, have a significantly time- and concentration-dependent protective role in ischemic astrocytes. We then investigated whether co-treatment with hypothermia and ginkgolides has a synergistic role to protect astrocytes against ischemia and reperfusion-induced injury. Cells were incubated with 18.75, 37.5 or 75 microg/ml of ginkgolides at 37, 32 or 28 degrees C for 24, 48 or 72 h before exposure to ischemia (24h) and then reperfusion (24h). Data showed that the co-treatment induced a significant decrease, rather than an increase as we had expected, in their cellular viabilities and anti-apoptotic abilities as compared with the cells treated by ginkgolides only. Western blot analysis demonstrated that hypothermia (32 or 28 degrees C for 24h) has no effect on the expression of Hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein, suggesting that HIF-1 alpha is not associated with the adverse effect of hypothermia on ginkgolides. The findings imply the importance of further investigating the effects of hypothermia on the pharmacological role or therapeutic efficacy of drugs commonly used clinically.
Published: 2009
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9. Analysis of Heart Rate Variability and Cardiac Autonomic Nerve Remodeling in Streptozotocin-induced Diabetic Rats

Author: Xue Wang, Du-Fang Ma, Hai-qing Lin, Jinlong Yang, Yue-Hua Jiang, Xiao Li, Ping Jiang, and Chuan-Hua Yang
Subjects: Male, medicine.medical_specialty, Tyrosine 3-Monooxygenase, Diabetic Cardiomyopathies, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Heart Ventricles, Ventricular Dysfunction, Right, Autonomic Nervous System, Streptozocin, Choline O-Acetyltransferase, Diabetes Mellitus, Experimental, Endocrinology, GAP-43 Protein, Diabetic Neuropathies, Heart Rate, Internal medicine, Heart rate, Nerve Growth Factor, Internal Medicine, medicine, Ventricular Dysfunction, Heart rate variability, Animals, Ciliary Neurotrophic Factor, Rats, Wistar, Autonomic nerve, Neuronal Plasticity, business.industry, Insulin, General Medicine, Streptozotocin, Choline acetyltransferase, Autonomic nervous system, Nerve growth factor, Autonomic Nervous System Diseases, business, Biomarkers, medicine.drug
Abstract: Background: Diabetes mellitus (DM) is associated with both cardiovascular and autonomic nervous system dysfunction. Spectral analysis of heart rate variability (HRV) can be used to monitor changes in response to autonomic innervation and stimulation of the heart. In this study, conducted in a rat model of diabetes, HRV and changes in associated neurotransmitters and neurotrophic factors in the right atrium (RA) were monitored. Methods: Diabetes was induced by streptozotocin (STZ) (60 mg/kg) in male Wistar rats, and HRV data were collected for 10 weeks by telemetry. Time and frequency domains of HRV data were analyzed using established metrics. The levels of various neural enzymes in the RA were determined by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence to characterize autonomic nerve remodeling. Insulin and methycobal were used to block the effects of STZ. Results: HRV parameters reflecting parasympathetic tone (SDNN, RMSSD and HF domains) sharply decreased in the first 3 weeks after STZ administration; measures of sympathetic tone (SDANN) increased. After a series of adjustments, cardiac autonomic nerve innervation reached a new equilibrium, with a dominance of sympathetic tone. RA levels of tyrosine hydroxylase (TH) increased, and choline acetyltransferase (ChAT) decreased, indicating autonomic nerve remodeling. Levels of growth associated protein-43 (GAP43) and nerve growth factor (NGF) increased during the period of diabetes-induced cardiac-nerve damage; however, the level of ciliary neurotrophic factor (CNTF) decreased. The physical condition and indexes of rats were normalized in different degree after administration of the insulin and methycobal, but not completely recovered. Conclusion: STZ-induced diabetes was associated with cardiac autonomic nerve dysfunction at both the organ and molecular levels. Parasympathetic nerves exhibited severe damage and/or weak recovery; remodeling of sympathetic nerves predominated during 10-weeks of STZ-induced diabetes.
Published: 2015

10. Cardiac Dysregulation and Myocardial Injury in a 6-Hydroxydopamine-Induced Rat Model of Sympathetic Denervation

Author: Yue-Hua Jiang, Du-Fang Ma, Jinlong Yang, Wen-ge Su, Xiao Li, Zhen Wang, Hai-qing Lin, and Ping Jiang
Subjects: Male, Heart Injury, medicine.medical_specialty, Heart Ventricles, medicine.medical_treatment, Fluorescent Antibody Technique, lcsh:Medicine, Enzyme-Linked Immunosorbent Assay, Rats, Sprague-Dawley, Microscopy, Electron, Transmission, Internal medicine, medicine, Animals, Heart rate variability, Sympathectomy, Oxidopamine, lcsh:Science, Denervation, Hydroxydopamine, Multidisciplinary, business.industry, lcsh:R, Heart, Vagus Nerve, Rats, Vagus nerve, Disease Models, Animal, Autonomic nervous system, medicine.anatomical_structure, Heart Injuries, Ventricle, Anesthesia, Cardiology, Cytokines, lcsh:Q, business, Research Article
Abstract: Background Cardiac sympathetic denervation is found in various cardiac pathologies; however, its relationship with myocardial injury has not been thoroughly investigated. Methods Twenty-four rats were assigned to the normal control group (NC), sympathectomy control group (SC), and a sympathectomy plus mecobalamin group (SM). Sympathectomy was induced by injection of 6-OHDA, after which, the destruction and distribution of sympathetic and vagal nerve in the left ventricle (LV) myocardial tissue were determined by immunofluorescence and ELISA. Heart rate variability (HRV), ECG and echocardiography, and assays for myocardial enzymes in serum before and after sympathectomy were examined. Morphologic changes in the LV by HE staining and transmission electron microscope were used to estimate levels of myocardial injury and concentrations of inflammatory cytokines were used to reflect the inflammatory reaction. Results Injection of 6-OHDA decreased NE (933.1 ± 179 ng/L for SC vs. 3418.1± 443.6 ng/L for NC, P < 0.01) and increased NGF (479.4± 56.5 ng/mL for SC vs. 315.85 ± 28.6 ng/mL for NC, P < 0.01) concentrations. TH expression was reduced, while ChAT expression showed no change. Sympathectomy caused decreased HRV and abnormal ECG and echocardiography results, and histopathologic examinations showed myocardial injury and increased collagen deposition as well as inflammatory cell infiltration in the cardiac tissue of rats in the SC and SM groups. However, all pathologic changes in the SM group were less severe compared to those in the SC group. Conclusions Chemical sympathectomy with administration of 6-OHDA caused dysregulation of the cardiac autonomic nervous system and myocardial injuries. Mecobalamin alleviated inflammatory and myocardial damage by protecting myocardial sympathetic nerves.
Published: 2015

11. Effects of quasi-periodicity on defect modes of photonic crystals

Author: Du-fang Shi, Xian-feng Chen, Xiao-ming Shen, Mei-ping Jiang, and Xiao-gang Chao
Subjects: Materials science, business.industry, Transfer-matrix method (optics), Physics::Optics, Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, law.invention, Quality (physics), law, Electric field, Optoelectronics, Electrical and Electronic Engineering, Photonics, business, Layer (electronics), Photonic crystal
Abstract: In this letter, the effects of Bragg-mirror quasi-periodicity on the shifts and quality factor in defect modes of photonic crystals are studied by using the transfer matrix method. Furthermore the influence of the quasi-periodicity on electric field enhancement effect inside the defect layer is studied, which is similar to that on the quality factor.
Published: 2006
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12. Enhancement effect of phase-conjugate waves of third order nonlinear medium in the Bragg microcavity

Author: Xian-feng Chen, Mei-ping Jiang, Guang Chen, Du-fang Shi, Xiao-ming Shen, and Chong-wen Ni
Subjects: Condensed Matter::Quantum Gases, Physics, business.industry, Phase (waves), Physics::Optics, Resonance, Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, law.invention, Optics, law, Optical medium, Electrical and Electronic Engineering, Photonics, business, Beam (structure), Photonic crystal, Conjugate
Abstract: The enhancement effect of the phase-conjugate wave produced by a third order nonlinear optical medium in a(AB) N (D)2 (BA)N Bragg microcavity made of one-dimensional photonic crystals is studied. The gain factor of the phase-conjugate wave is derived when the resonance condition is satisfied by the incident optical wave and the Bragg microcavity mode. Because of stronger resonance enhancement to incident pump beam given by the Bragg microcavity, the enhancement effect of the phase-conjugate wave produced by a third order nonlinear optical medium inside Bragg microcavity is more outstanding than that caused by the naked third order nonlinear optical medium. The theoretical analysis and the numerical calculation show the Bragg microcavity with larger numberN of periods is identical with a Fabry-Perot cavity when the resonance condition is satisfied by the incident optical wave and the Bragg microcavity mode.
Published: 2006
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13. Transmission spectra of one-dimensional photonic crystals including negative-refractive-index media

Author: Du-fang Shi, Xiao-ming Shen, Mei-ping Jiang, and Xian-feng Chen
Subjects: Total internal reflection, Materials science, Condensed matter physics, business.industry, Band gap, Physics::Optics, Condensed Matter Physics, Polarization (waves), Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Transverse mode, Wavelength, Optics, Electrical and Electronic Engineering, Photonics, business, Refractive index, Photonic crystal
Abstract: We introduce a new model of one-dimensional (1D) photonic crystal composed of alternately arranged RHM and LHM layers with positive and negative refractive indices respectively, for which the transmission spectra of the model are calculated numerically with the transfer matrix method, and the bandgap structure and the polarization properties are analyzed. We found that the introduction of negative refractive index layers (i.e. LHM medium layers) gives rise to some peculiar band—gap structure and polarization properties as follows. Firstly, the forbidden bands are extremely wide and the transmission bands are very sharp without oscillation; and secondly, the change of incident angle has different influences on the forbidden bands of TE and TM modes. For the TM mode, the forbidden band width decreases substantially and finally vanishes, and for the TE mode with central wavelength, the total reflection happens at any incident angle.
Published: 2005
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14. GW28-e1090 Astragaloside IV Ameliorates Obesity-Associated Hypertension by Up-Regulating α7 Nicotinic Acetylcholine Receptor

Author: Yongcheng Wang, Ping Jiang, Xiao Li, Jinlong Yang, Xue Wang, and Du-Fang Ma
Subjects: Agonist, medicine.drug_class, business.industry, Pharmacology, medicine.disease, Obesity, Nicotine, Astragaloside IV, α7 nicotinic acetylcholine receptor, medicine, Cardiology and Cardiovascular Medicine, Adverse effect, business, medicine.drug
Abstract: Nicotine, as a non-selective agonist of α7 nicotinic acetylcholine receptor (α7nAChR), has been shown to possess anti-obesity and anti-hypertension properties; however, it is not applicable due to its adverse effects. We tested the hypothesis that Astragaloside IV (As IV), known to counteract
Published: 2017
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15. Properties of defect mode and optical enhancement of 1D photonic crystals with a defect layer of negative refractive index material

Author: Xiao-ming Shen, Mei-ping Jiang, Du-fang Shi, and Xian-feng Chen
Subjects: Materials science, business.industry, Band gap, Mode (statistics), Physics::Optics, Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, law.invention, Wavelength, Optics, law, Electrical and Electronic Engineering, Photonics, business, Layer (electronics), Refractive index, Photonic crystal
Abstract: The band gap properties of one-dimensional photonic crystals with a defect layer of negative refractive index materials are studied. The defect mode width is bigger than that of conventional one-dimensional photonic crystals with a defect layer of positive refractive index materials. The defect mode of the former is different from that of the latter, shifts towards the direction of high frequency (short wavelength), and has a bigger shifting velocity. Furthermore the effects on the transmission properties of the former photonic crystals caused by change in the position of the defect layer of negative refractive index are investigated. Finally the optical enhancement of the former photonic crystals is also investigated.
Published: 2005
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16. Data mining research in wireless sensor network based on genetic BP algorithm

Author: Du Fang, Wang Mengmeng, Xiu Debin, Shi Yunbo, and Wang Rongxin
Subjects: Engineering, Random search, Brooks–Iyengar algorithm, Approximation error, business.industry, Data mining, business, computer.software_genre, Wireless sensor network, Algorithm, computer, Backpropagation, Chlorine gas
Abstract: This paper associated the advantages of genetic and BP algorithm, and studied the application of genetic BP algorithm in wireless sensor network (WSN) data mining. It built a three-layer BP network based on the rapid random search ability of genetic and the mapping capability of BP algorithm, so the redundant history data in WSN could be mined and reused. The tests to 1000 groups of chlorine concentration data from chlorine gas sensor network had been conducted. And according to the comparison between predicted concentration and actual concentration, the maximum relative error was 11.8%, and the maximum average error was 6.96%. So the conclusion could be obtained that the algorithm model established by the paper is feasible and reliable under the condition of no explosive concentration leakage.
Published: 2013
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17. GW27-e0800 Cardiac Dysregulation and Myocardial Injury in a 6-Hydroxydopamine-Induced Rat Model of Sympathetic Denervation and Prevention effect of Guizhi Decoction

Author: Jiang Ping, Li Xiao, Yang Jin-Long, Ma Du-Fang, and Jiang Yue-Hua
Subjects: Hydroxydopamine, Sympathetic nervous system, business.industry, Rat model, medicine.disease, Sympathetic Denervation, medicine.anatomical_structure, Heart failure, Diabetic cardiomyopathy, Anesthesia, medicine, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, Guizhi decoction
Abstract: Previous studies have shown that chronic activation of sympathetic nervous system is an unfavorable factor of cardiovascular diseases, However, studies have revealed that cardiac denervation often exists in patients with diabetic cardiomyopathy, heart failure or myocardial infarction. Until now
Published: 2016
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18. Limited-view optical tomography technique and its application to temperature field measurement in flow of hot air

Author: Chen Shao-hua, Xiao Xudong, Zhong Zhiyou, and Shi Du-fang
Subjects: Physics, medicine.diagnostic_test, Field (physics), business.industry, Mechanical Engineering, Nozzle, Orthographic projection, Computational Mechanics, Holography, Image processing, law.invention, Cross section (physics), Optics, Simultaneous Algebraic Reconstruction Technique, law, medicine, Optical tomography, business
Abstract: In this paper, a limited-view optical tomography technique is presented, which contains an orthographic holography system, an image processing system and the simultaneous algebraic reconstruction technique (SART). Using this technique, the temperature field of a cross section in the flow of hot air from a nozzle is measured. The measured results are satisfactory.
Published: 1995
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19. Investigation and analysis on the adverse reactions caused by 12 kinds of commonly used traditional Chinese medicine injections

Author: Li Wang, Kang Xiaogang, Shuang-Xing Hou, Zhongliang Wu, Lijuan Liu, Lian-fang Yuan, Xuedong Liu, Gang Zhao, Yan-chun Deng, and Du Fang
Subjects: Drug, medicine.medical_specialty, Traditional medicine, business.industry, media_common.quotation_subject, Alternative medicine, Retrospective cohort study, Plant Science, Traditional Chinese medicine, medicine.disease, Microbiology, Drug usage, Clinical trial, Infectious Diseases, medicine, Intensive care medicine, business, Adverse effect, Adverse drug reaction, media_common
Abstract: This study was aimed to explore the characteristics and rules of the adverse drug reactions (ADR) caused by the 12 kinds of traditional Chinese medicine injections and to provide reference for rational clinical drug use. Retrospective study methods are adopted to make statistical analysis on the cases of ADR caused by the 12 kinds of commonly used traditional Chinese medicine injections, such as Chuanhuning, Yanhuning, Chuanxiongzine, Bupleurum, etc. reported in the knowledge resource database in the China Hospital Knowledge Database (CHKD) from 2006 to 2010. The ADR of these 12 kinds of traditional Chinese medicine injections have high incidence in elderly patients and occur mostly within 30 min after drug usage; this results mainly as systemic damage, manifested as allergic reaction, severe case can cause allergic shock, and each traditional Chinese medicine injection has its own features. The clinical medical care personnel shall learn more about the ADR of traditional Chinese medicine injections and reduce or avoid the occurrence of ADR. Key words: Traditional Chinese medicine injection, adverse drug reaction, rational drug use.
Published: 2012
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20. Research on virtual single-flank-meshing measurement of micro spur gear

Author: Yang Hairong, Lu Jiuming, Zhao Xindong, Li Wen, and Du Fang
Subjects: InformationSystems_GENERAL, Engineering, Flank, Observational error, Involute, Spur gear, business.industry, Process (computing), Mechanical engineering, Measurement uncertainty, business, Image measurement
Abstract: Because the integrated error measurement was not done in current micro-gear image measurement, the paper presents the virtual single-flank-meshing measuring methods of micro spur gear, and then introduces the principle, algorithm and digital simulation process of the virtual measurement. At first we constructed the standard involute spur gear, then the meshing process of the standard involute spur gear with the measured micro gear was simulated, in end the virtual measuring method of micro spur gear single flank meshing is studied, and its performance is verified, the method is feasible.
Published: 2010
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21. Optical transmission properties of Bragg microcavity containing left handed materials

Author: Du-fang Shi, Mei-ping Jiang, Xian-feng Chen, Xudong Wang, and Xiao-ming Shen
Subjects: Condensed Matter::Quantum Gases, Quantum optics, Materials science, Bistability, business.industry, Physics::Optics, Bragg's law, Dielectric, Optics, Fiber Bragg grating, Dispersion (optics), Transmittance, Optoelectronics, business, Refractive index
Abstract: It is investigated the optical transmission properties of the Bragg microcavity sandwiched between Bragg reflectors which are composed of alternately arranged different dielectrics with positive and negative refractive indices. The defect layer thickness, incident angle of incident wave, quasi-periodicity of the Bragg reflectors and dispersion of the negative-refractive-index dielectric all have influence on the transmission spectra. Comparison of optical bistable characteristics is presented for the following three nonlinear Bragg microcavities. The first has Bragg reflectors with periodic structure containing non-dispersive negative-refractive-index dielectric; the second has the same structure as the first, however, the negative-refractive index dielectric is dispersive; the third also has periodic structure, however, where the Bragg reflectors are composed of alternately arranged dielectrics with different positive- refractive-indices. It is analyzed influence of the incident angle on the bistability of the nonlinear Bragg microcavity containing non-dispersive dielectrics.
Published: 2005
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22. Optical bistable behavior involving photonic crystals nonlinear cavity

Author: Du Fang Shi and K. F. Deng
Subjects: Physics, Nonlinear system, Hysteresis, Optics, Bistability, business.industry, Reflection (physics), Physics::Optics, business, Optical switch, Refractive index, Photonic crystal, Optical bistability
Abstract: We present an analytical model and numerical experiments to describe optimal bistable switching involving photonic crystals nonlinear cavity. The involving photonic crystals nonlinear cavity is particularly suitable for large-scale all-optical integration. It is interesting to show that the refractive index of the system can be altered by the incident intensity when the incident frequency is tuned to the evanescent mode and the cavity contains a nonlinear Kerr medium. The response of this system to high-intensity incident waves is studied in detail. A cavity host a localized mode at 1.55 um with a Q of 4000 and a mode volume of 0.055 um3, we predict the onset of bistable reflection at incident powers of ~40 mW. The downstream reflections lead to hysteresis loops in the reflectivity that are topologically distinct from conventional Lorentzian-derived loops characteristic of isolated Fabry-Perot cavities. We provide a stability argument that reveals the unstable branches of these unique hysteresis loops, and we illustrate some of the rich bistable behaviors that can be engineered with such downstream sources, this fact may be used to obtain more flexibility in designing nonlinear devices.
Published: 2005
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23. Optimal bistable switching in photonic crystals with defect of nonlinear dielectric materials

Author: Du Fang Shi and K. F. Deng
Subjects: Nonlinear system, Optics, Materials science, Bistability, business.industry, Nonlinear photonic crystal, Physics::Optics, Dielectric, business, Optical switch, Multistability, Optical bistability, Photonic crystal
Abstract: In this paper, the propagation properties of the electromagnetic (EM) waves in one-dimension photonic crystals (PC) with nonlinear defects layer closed by periodic layered structures are reported. It is shown that in the presence of the nonlinearity, the transmission properties are strongly modulated by both the frequency and intensity, and the system exhibits bistability and multistability. Moreover, we find that both the switching-up and switching-down intensities of the bistable response can be made very low, when the intensity of the incident wave matches the defect mode of the structure. By use of the nonlinear finite-difference time-domain (NFDTD) method, we simulate the bistable threshold of the nonlinear photonic crystals with the kerr medium and the feasibility of making a switch utilizing such a structure. Bistable swithching with a low threshold intensity of 0.0007 kW/cm 2 is obtained. The numerical experiments describe optimal bistable switching in a nonlinear photonic crystal system. A photonic crystal enables the device to operate in single-mode fashion, as if it were effectively one-dimensional. This provides optimal control over the input and output and facilitates further large-scale optical integration.
Published: 2005
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24. Analysis of bistable switching threshold in one-dimensional photonic crystals

Author: Mei-ping Jiang, Xingfang Jiang, Du Fang Shi, and Xiao-ming Shen
Subjects: Materials science, Condensed matter physics, Bistability, High-refractive-index polymer, business.industry, Transfer-matrix method (optics), Physics::Optics, Optical switch, Transfer matrix, Optical bistability, Optics, business, Refractive index, Photonic crystal
Abstract: We study the optical bistable properties in one-dimensional photonic crystal with symmetric structure (AB) N (D) M (BA) N , where A is high refractive index medium, B is low refractive index medium, D is defect layer, N is the number of layer periods at the left and right of the defect layer. M determines the thickness of the defect layer with Kerr medium. First, we analyze mechanisms producing bistability by the structure consisted of a nonlinear layer sandwiched between Bragg reflectors. Then by using the transfer matrix method, we calculate numerically the threshold value of the bistability switching in one-dimensional photonic crystals with structure (AB) N (D) M (BA) N . The investigations show that the number of layer periods (N) and the thickness of the defect layer (M) influence the threshold value of the bistability switching. We confirm the parameter of the bistability switching to produce the lower threshold value.
Published: 2005
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25. Bistability of photonic crystals with nonlinear dielectric materials

Author: Shouzhi Xia, Du-fang Shi, and Xuejun Liu
Subjects: Materials science, Bistability, business.industry, Attenuation coefficient, Transmittance, Physics::Optics, Optoelectronics, Dielectric, business, Finite thickness, Electromagnetic radiation, Refractive index, Photonic crystal
Abstract: We report on the properties of light transmission in one-dimension photonic crystals with defects of nonlinear dielectric material, photonic crystals have simple and complex period dielectric structure with multi-unit layer. In particular, we are interested in the transmittance of defect mode and the intensity enhancement factor of localized light. By the transfer-matrix method, we can calculate the electromagnetic waves transmission through a photonic crystal, the intensity enhancement factor of localized light can be obtained. The method calculated the transmission properties normal incident on a finite thickness slab of material. The numerical calculation shows that the transmission with defect layer of nonlinear dielectric material can induced to bring about change by the input intensity of light, and the change of the transmission shows the bistability. For simple and complex period dielectric in PC, if the threshold of input intensity be satisfied, the properties should be emerged easier. For complex period dielectric in PC, the transmission can show the property of complex results. When the total transmission is big, the bistability is also displayed. In addition, the character is seen to determine by the saturation absorption coefficient of the defect medium, the refractive index ratio and the number of layers.
Published: 2004
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26. Measurement of optical fiber dispersion slope and self-phase modulation effect using fast Fourier transform

Author: Du-fang Shi, Xuejun Liu, and Shouzhi Xia
Subjects: Physics, Optics, Fiber optic sensor, business.industry, Cross-phase modulation, Single-mode optical fiber, Physics::Optics, Dispersion-shifted fiber, Polarization-maintaining optical fiber, Self-phase modulation, business, Graded-index fiber, Phase modulation
Abstract: The dispersion and self phase modulation is two important factors of the limit transmission distance in optical fiber communication. A novel method for measuring the dispersion slope of a long single-mode fiber was reported. By asymmetric modulation and Mach-Zehnder interferometer, the interferometer causes counter propagating wave to travel in test fiber with different propagation constants. We introduced the fast Fourier transform technique, the autocorrelation function is brought forward, and the information of the interference fringe is analysis with high speed so that the accuracy of signal is estimated. Successively, the experiment was performed on the test fiber to determine the nonlinear refractive index and self phase modulation, exact pulse bandwidth solution is presented. We found that quantity was depends on the intensity of incidence light and the peak power, and the frequency spectrum is broadening clearly. The result shows that the intensity input and the peak power can affect the phase shift value.
Published: 2004
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27. Clinical pathologic study on effect of Qianggan capsule in treating patients of chronic hepatitis B with liver cirrhosis

Author: Zhang Wan-dai, Yan-long Zhao, Xu Ke-cheng, Liu-ming Yang, Zuo Bei-hai, Zuo Jian-sheng, Chen Zhuo-ying, Chen Du-fang, and Wu Zhi-rong
Subjects: medicine.medical_specialty, Pathology, Cirrhosis, medicine.diagnostic_test, biology, business.industry, Therapeutic effect, Capsule, General Medicine, medicine.disease, Gastroenterology, chemistry.chemical_compound, B vitamins, chemistry, Alanine transaminase, Liver biopsy, Internal medicine, Hyaluronic acid, medicine, biology.protein, business, Pathological
Abstract: To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect. Sixty-three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group (n=45) and the control group (n=18). Both groups were treated with general liver protective drugs, such as Glucurone and vitamins B complex for 6 months. To the treated group, QGC was used additionally. The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid (HA), collagen type IV (C-IV) and laminin (LN) as well as the pathological examination of liver biopsy were observed before and after treatment. The liver cirrhosis indexes, HA, C-IV and LN, were improved significantly in the treated group after treatment,P 0.05. Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57. 8% and that on liver fibrosis stage was 75. 6%, which were significantly improved as compared with those before treatment (P 0.05) QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis, and could lower the serum liver fibrosis related indexes effectively.
Published: 2002
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28. Migration studies on esophageal precancerous and cancerous lesions in Linxian, China

Author: Li Shaohua, Zhou Li, Zhang Yanrui, Kuai Dayu, Jiang Yanan, Wang Ran, Fan Zongmin, Wang Li Dong, Gao Fusheng, Feng Xiaoshan, Du Fang, Sun Zhe, Chang Zhiwei, Jiao Xin-ying, Li Jilin, Wu Huifang, Qin Yupei, Lv Xiaodong, Li Congyu, Zhou Jianwei, Fan Yujing, Chang Fu-bao, Gao Shanshan, He Xin, Liu Weina, Wang Junkuan, Wen Wei, Zhang Yanxia, Wang Nengchao, Liu Bin, Guo Tao, Liu Xiaoli, Du Xianjuan, Di Xia, Shao Shan, Li Ping-juan, Zhang Guangping, and Feng Changwei
Subjects: Migration studies, Pathology, medicine.medical_specialty, business.industry, Gastroenterology, Medicine, business, China
Published: 2006
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29. Polarization properties of one-dimensional photonic crystal tunneling mode containing metamaterials

Author: Zhang Qin, Huang Hai-Ming, Shi Du-fang, Li Wen-Sheng, and Luo Shi-Jun
Subjects: Materials science, business.industry, General Physics and Astronomy, Optoelectronics, Metamaterial, business, Polarization (waves), Leaky mode, Photonic crystal
Abstract: An (AB)N(BA)N-type one-dimensional photonic crystal is made from common material A(SiO2) and electric single-negative material B. Numerical calculation results indicate that there is a very sharp tunneling model at 1907.3 nm of the original band. When the incident angle increases, the transmittance and the full-width half-maximum of the tunneling mode remains the same, but its position is blue shifted. The value of |d/d| turns larger when the incident angel is in a range from 15 to 65. When permeability of B medium B increases from 5 to 10, the position of the tunneling model is only red shifted. When geometric thickness of the dielectric increases, the transmittance of the tunneling model remains unchanged, but its position is red shifted obviously and its full-width half-maximum increase slightly.
Published: 2012
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30. Critical care admission following elective surgery was not associated with survival benefit

Author: Kahan, Brennan C., Desponia, Koulenti, Kostoula, Arvaniti, Vanessa, Beavis, Douglas, Campbell, Matthew, Chan, Rui, Moreno, Pearse, Rupert M., Scott, Beattie, Pierre-Alain, Clavien, Nicolas, Demartines, Lee, A Fleisher, Mike, Grocott, James, Haddow, Andreas, Hoeft, Peter, Holt, Naomi, Pritchard, Andrew, Rhodes, Duminda, Wijeysundera, Matt, Wilson, Tahania, Ahmed, Kirsty, Everingham, Russell, Hewson, Marta, Januszewska, Rupert, M Pearse, Mandeep-Kaur, Phull, Richard, Halliwell, Mark, Shulman, Paul, Myles, Werner, Schmid, Michael, Hiesmayr, Patrick, Wouters, Stefan de Hert, Suzana, Lobo, Xiangming, Fang, Lars, Rasmussen, Emmanuel, Futier, Matthieu, Biais, Aurélien, Venara, Karem, Slim, Michael, Sander, Despoina, Koulenti, Mathew, Chan, Atul, Kulkarni, Susilo, Chandra, Aida, Tantri, Emad, Geddoa, Muntadhar, Abbas, Giorgio Della Rocca, Datin, Sivasakthi, Marzida, Mansor, Pastor, Luna, Arthur, Bouwman, Wolfgang, Buhre, Tim, Short, Tunde, Osinaike, Ricardo, Matos, Ioana, Grigoras, Mikhail, Kirov, Denis, Protsenko, Bruce, Biccard, Cesar, Aldecoa, Michelle, Chew, Christoph, Hofer, Martin, Hubner, James, Ditai, Tamas, Szakmany, Lee, Fleisher, Marissa, Ferguson, Michael, Macmahon, Ritchie, Cherian, Helen, Currow, Kathirgamanathan, Kanathiban, David, Gillespie, Edward, Pathmanathan, Katherine, Phillips, Jenifer, Reynolds, Joanne, Rowley, Jeanene, Douglas, Ross, Kerridge, Sameer, Garg, Michael, Bennett, Megha, Jain, David, Alcock, Nico, Terblanche, Rochelle, Cotter, Kate, Leslie, Marcelle, Stewart, Nicolette, Zingerle, Antony, Clyde, Oliver, Hambidge, Adam, Rehak, Sharon, Cotterell, Wilson Binh Quan Huynh, Timothy, Mcculloch, Erez, Ben-Menachem, Thomas, Egan, Jennifer, Cope, Paul, Fellinger, Simone, Haselberger, Caroline, Holaubek, Paul, Lichtenegger, Florian, Scherz, Franz, Hoffer, Veronika, Cakova, Andreas, Eichwalder, Norbert, Fischbach, Reinhold, Klug, Elisabeth, Schneider, Martin, Vesely, Reinhart, Wickenhauser, Karl Gernot Grubmueller, Marion, Leitgeb, Friedrich, Lang, Nancy, Toro, Marlene, Bauer, Friedrich, Laengle, Thomas, Mayrhofer, Christian, Buerkle, Karin, Forstner, Reinhard, Germann, Harald, Rinoesl, Elke, Schindler, Ernst, Trampitsch, Gerhard, Fritsch, Christian, Szabo, Jawad, Bidgoli, Hans, Verdoodt, Patrice, Forget, David, Kahn, Fernande, Lois, Mona, Momeni, Caroline, Prégardien, Audrey, Pospiech, Arnaud, Steyaert, Laurent, Veevaete, Dirk De Kegel, Karen De Jongh, Luc, Foubert, Carine, Smitz, Marcel, Vercauteren, Jan, Poelaert, Veerle Van Mossevelde, Jacques, Abeloos, Stefaan, Bouchez, Marc, Coppens, Luc De Baerdemaeker, Isabel, Deblaere, Ann De Bruyne, Stefan De Hert, Kristine, Fonck, Bjorn, Heyse, Tom, Jacobs, Koen, Lapage, Anneliese, Moerman, Martine, Neckebroek, Aliaksandra, Parashchanka, Nathalie, Roels, Nancy Van Den Eynde, Michael, Vandenheuvel, Jurgen Van Limmen, Ann, Vanluchene, Caroline, Vanpeteghem, Piet, Wyffels, Christel, Huygens, Punitha, Vandenbempt, Marc Van de Velde, Dimitri, Dylst, Bruno, Janssen, Evelien, Schreurs, Fábia Berganton Aleixo, Keulle, Candido, Hugo Dias Batista, Mario, Guimarães, Jaqueline, Guizeline, João, Hoffmann, Suzana, M Lobo, Francisco Ricardo Lobo, Vinícius, Nascimento, Katia, Nishiyama, Lucas, Pazetto, Daniela, Souza, Rodrigo Souza Rodrigues, Ana Maria Vilela Dos Santos, Jaquelline, Jardim, Joao, Silva, Paulo do Nascimento Junior, Thalissa Hermínia Baio, Gabriel Isaac Pereira de Castro, Henri Roger Watanabe Oliveira, Cristina Prata Amendola, Gutemberg, Cardoso, Daniela, Ortega, Ana Flavia Brotto, Mirella Cristine De Oliveira, Álvaro, Réa-Neto, Fernando, Dias, Pedro, Azambuja, Marcos Freitas Knibel, Antonio, Martins, William, Almeida, Calim Neder Neto, Maria Angela Tardelli, Eliana, Caser, Marcio, Machado, Crisitiano, Aguzzoli, Sérgio, Baldisserotto, Fernanda Beck Tabajara, Fernanda, Bettega, La Hore Correa Rodrigues Júnior, Julia de Gasperi, Lais, Faina, Marcos Farias Nolasco, Bruna Ferreira da Costa Fischer, Mariana Fosch de Campos Ferreira, Cristina, Hartmann, Marta, Kliemann, Gustavo Luis Hubert Ribeiro, Julia Merladete Fraga, Thiago Motta Netto, Laura Valduga Pozza, Paulo Rafael Wendling, Caroline, Azevedo, Juliana, Garcia, Marcel, Lopes, Bernardo, Maia, Paula, Maselli, Ralph, Melo, Weslley, Mendes, Matheus, Neves, Jacqueline, Ney, Claudio, Piras, Christopher, Applewhaite, Adrienne, Carr, Lorraine, Chow, Kaylene, Duttchen, Julena, Foglia, Michael, Greene, Ashley, Hinther, Kendra, Houston, Thomas Jared McCormick, Jennifer, Mikhayel, Sam, Montasser, Alex, Ragan, Andrew, Suen, Adrianna, Woolsey, Hai Chuan Yu, Duane, Funk, Stephen, Kowalski, Regina, Legaspi, Heather, Mcdonald, Faisal, Siddiqui, Jeremy, Pridham, Bernadette, Rowe, Sonia, Sampson, Barton, Thiessen, Geoff, Zbitnew, Andre, Bernard, Ronald, George, Philip, Jones, Rita, Moor, Naveed, Siddiqui, Alexandra, Wolfer, Diem, Tran, Denyse, Winch, Gary, Dobson, Thomas, Mccormick, Osama, Montasser, Richard, Hall, Leyla, Baghirzada, Si Yuan Dai, Gregory, Hare, Esther, Lee, Uma, Shastri, Albert, Tsui, Anmol, Yagnik, Danielle, Alvares, Stephen, Choi, Heather, Dwyer, Kathrina, Flores, Colin, Mccartney, Priya, Somascanthan, Carroll, Jo, Janneth, Pazmino-Canizares, Noam, Ami, Vincent, Chan, Anahi, Perlas, Ruth, Argue, Katie, Lavis, Kelly, Mayson, Ying, Cao, Hong, Gao, Tingju, Hu, Jie, Lv, Jian, Yang, Yang, Yang, Zhong, Yi, Jing, Zhou, Xiaohua, Zou, Miao, He, Xiaoying, Li, Dihuan, Luo, Haiying, Wang, Tian, Yu, Liyong, Chen, Lijun, Wang, Yunfei, Cai, Zhongming, Cao, Yanling, Li, Jiaxin, Lian, Haiyun, Sun, Sheng, Wang, Zhipeng, Wang, Kenru, Wang, Zhu, Yi, Xindan, Du, Hao, Fan, Yunbin, Fu, Lixia, Huang, Yanming, Huang, Haifang, Hwan, Hong, Luo, Pi-Sheng, Qu, Fan, Tao, Zhen, Wang, Guoxiang, Wang, Shun, Wang, Yan, Zhang, Xiaolin, Zhang, Chao, Chen, Weixing, Wang, Zhengyuan, Liu, Lihua, Fan, Jing, Tang, Yijun, Chen, Yongjie, Chen, Yangyang, Han, Changshun, Huang, Guojin, Liang, Jing, Shen, Jun, Wang, Qiuhong, Yang, Jungang, Zhen, Haidong, Zhou, Junping, Chen, Zhang, Chen, Xiaoyu, Li, Meng, Bo, Haiwang, Ye, Xiaoyan, Zhang, Yanbing, Bi, Jianqiao, Cao, Fengying, Guo, Hong, Lin, Yang, Liu, Meng, Lv, Pengcai, Shi, Xiumei, Song, Chuanyu, Sun, Yongtao, Sun, Yuelan, Wang, Shenhui, Wang, Min, Zhang, Rong, Chen, Jiabao, Hou, Yan, Leng, Qing-Tao, Meng, Qian, Li, Zi-Ying, Shen, Zhong-Yuan, Xia, Rui, Xue, Yuan, Zhang, Zhao, Bo, Xian-Jin, Zhou, Qiang, Chen, Huinan, Guo, Yongqing, Guo, Yuehong, Qi, Zhi, Wang, Jianfeng, Wei, Weiwei, Zhang, Lina, Zheng, Bao, Qi, Yaqiu, Chen, Yijiao, Chen, Yue, Fei, Nianqiang, Hu, Xuming, Hu, Min, Lei, Xiaoqin, Li, Xiaocui, Lv, Fangfang, Miao, Lingling, Ouyang, Qian, Lu, Conyu, Shen, Sun, Yu, Yuting, Wang, Dong, Wang, Chao, Wu, Liyuan, Xu, Jiaqi, Yuan, Lina, Zhang, Huan, Zhang, Yapping, Zhang, Jinning, Zhao, Chong, Zhao, Lei, Zhao, Tianzhao, Zheng, Dachun, Zhou, Haiyan, Zhou, Zhou, Ce, Kaizhi, Lu, Ting, Zhao, Changlin, He, Hong, Chen, Shasha, Chen, Baoli, Cheng, Jie, He, Lin, Jin, Caixia, Li, Hui, Li, Yuanming, Pan, Yugang, Shi, Xiao Hong Wen, Shuijing, Wu, Guohao, Xie, Kai, Zhang, Bing, Zhao, Xianfu, Lu, Feifei, Chen, Qisheng, Liang, Xuewu, Lin, Yunzhi, Ling, Gang, Liu, Jing, Tao, Yang, Lu, Jialong, Zhou, Fumei, Chen, Yunlin, Feng, Benchao, Hou, Jiamei, Lin, Mei, Liu, Foquan, Luo, Xiaoyun, Shi, Yingfen, Xiong, Lin, Xu, Shuangjia, Yang, Qin, Zhang, Huaigen, Zhang, Weihong, Zhao, Weilu, Zhao, Yun, Bai, Linbi, Chen, Sijia, Chen, Qinxue, Dai, Wujun, Geng, Kunyuan, Han, Xin, He, Luping, Huang, Binbin, Ji, Danyun, Jia, Shenhui, Jin, Qianjun, Li, Dongdong, Liang, Shan, Luo, Lulu, Lwang, Yunchang, Mo, Yuanyuan, Pan, Xinyu, Qi, Meizi, Qian, Jinling, Qin, Yelong, Ren, Yiyi, Shi, Junlu, Wang, Junkai, Wang, Leilei, Wang, Junjie, Xie, Yixiu, Yan, Yurui, Yao, Mingxiao, Zhang, Jiashi, Zhao, Xiuxiu, Zhuang, Yanqiu, Ai, Fang, Du, Long, He, Ledan, Huang, Zhisong, Li, Huijuan, Li, Yetong, Li, Liwei, Li, Meng, Su, Yazhuo, Yuan, Enman, Zhang, Jie, Zhang, Shuna, Zhao, Zhenrong, Ji, Ling, Pei, Wang, Li, Chen, Chen, Beibei, Dong, Jing, Li, Ziqiang, Miao, Hongying, Mu, Chao, Qin, Lin, Su, Zhiting, Wen, Keliang, Xie, Yonghao, Yu, Fang, Yuan, Xianwen, Hu, Zhang, Ye, Wangpin, Xiao, Zhipeng, Zhu, Qingqing, Dai, Kaiwen, Fu, Rong, Hu, Xiaolan, Hu, Song, Huang, Yaqi, Li, Yingping, Liang, Shuchun, Yu, Zheng, Guo, Yan, Jing, Tang, Na, Jie, Wu, Dajiang, Yuan, Ruilin, Zhang, Xiaoying, Zhao, Yuhong, Li, Hui-Ping, Bai, Chun-Xiao, Liu, Fei-Fei, Liu, Wei, Ren, Xiu-Li, Wang, Guan-Jie, Xu, Na, Hu, Bo, Li, Yangwen, Ou, Yongzhong, Tang, Shanglong, Yao, Shihai, Zhang, Cui-Cui, Kong, Bei, Liu, Tianlong, Wang, Wei, Xiao, Bo, Lu, Yanfei, Xia, Jiali, Zhou, Fang, Cai, Pushan, Chen, Shuangfei, Hu, Hongfa, Wang, Qiong, Xu, Liu, Hu, Liang, Jing, Bin, Li, Qiang, Liu, Yuejiang, Liu, Xinjian, Lu, Zhen Dan Peng, Xiaodong, Qiu, Quan, Ren, Youliang, Tong, Jin, Wang, Yazhou, Wen, Qiong, Wu, Jiangyan, Xia, Jue, Xie, Xiapei, Xiong, Shixia, Xu, Tianqin, Yang, Hui, Ye, Ning, Yin, Jing, Yuan, Qiuting, Zeng, Baoling, Zhang, Kang, Zheng, Jing, Cang, Shiyu, Chen, Fan, Yu, Shuying, Fu, Xiaodong, Ge, Baolei, Guo, Wenhui, Huang, Linghui, Jiang, Xinmei, Jiang, Liu, Yi, Yan, Pan, Yun, Ren, Shan, Qi, Jiaxing, Wang, Fei, Wang, Chi, Wu, Xiaoguang, Zhang, Ida Cecilie Christiansen, Simon Nørgaard Granum, Bodil Steen Rasmussen, Morten, Daugaard, Rajiv, Gambhir, Guðný Erla Steingrímsdóttir, Peter, Jensen-Gadegaard, Karsten Skovgaard Olsen, Hanna, Siegel, Katrine Zwicky Eskildsen, Mona Ring Gätke, Ida, Wibrandt, Simon Bisgaard Heintzelmann, Kai Henrik Wiborg Lange, Rune Sarauw Lundsgaard, Louise, Amstrup-Hansen, Claus, Hovendal, Michael, Larsen, Mette, Lenstrup, Tina, Kobborg, Jens Rolighed Larsen, Anette Barbre Pedersen, Søren Hübertz Smith, Rebecca Monett Oestervig, Arash, Afshari, Cheme, Andersen, Kim, Ekelund, Erik Lilja Secher, Birgitte, Brandsborg, Helene, Beloeil, Sigismond, Lasocki, Alexandre, Ouattara, Marlene, Sineus, Serge, Molliex, Marie Lim Legouge, Florent, Wallet, Antoine, Tesniere, Christophe, Gaudin, Paul, Lehur, Emma, Forsans, Stéphane de Rudnicki, Valerie Serra Maudet, Didier, Mutter, Ghassan, Sojod, Mehdi, Ouaissi, Jean-Marc, Regimbeau, Jacques, Desbordes, Nicolas, Comptaer, Diae El Manser, Sabine, Ethgen, Gilles, Lebuffe, Patrick, Auer, Christine, Härtl, Maria, Deja, Kirill, Legashov, Susanne, Sonnemann, Carola, Wiegand-Loehnert, Elke, Falk, Marit, Habicher, Stefan, Angermair, Beatrix, Laetsch, Katrin, Schmidt, Christian Von Heymann, Axel, Ramminger, Florian, Jelschen, Svenja, Pabel, Andreas, Weyland, Elke, Czeslick, Jochen, Gille, Michael, Malcharek, Armin, Sablotzki, Katharina, Lueke, Peter, Wetzel, Joerg, Weimann, Franz-Peter, Lenhart, Florian, Reichle, Frederike, Schirmer, Michael, Hüppe, Karl, Klotz, Carla, Nau, Julika, Schön, Thomas, Mencke, Christina, Wasmund, Carla, Bankewitz, Georg, Baumgarten, Andreas, Fleischer, Vera, Guttenthaler, Yvonne, Hack, Katharina, Kirchgaessner, Olja, Männer, Marlen, Schurig-Urbaniak, Rafael, Struck, Rebekka van Zyl, Maria, Wittmann, Ulrich, Goebel, Sarah, Harris, Siegfried, Veit, 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Diaconescu, Ciresica, Iosep, Gabriel Florin, Pulbere, Dorin, Ursu, Irina, Balanescu, Andreea, Grintescu, Ioana, Mirea, Liliana, Rentea, Irina, Vartic, Mihaela, Lupu, Mary-Nicoleta, Stanescu, Dorin, Streanga, Lavinea, Antal, Oana, Hagau, Natalia, Patras, Dumitru, Petrisor, Cristina, Tosa, Flaviu, Tranca, Sebastian, Copotoiu, Sanda Maria, Ungureanu, Liviu Lucian, Harsan, Cristian Remu, Papurica, Mariu, Cernea, Daniela Denisa, Dragoescu, Nicoleta Alice, Aflori, Laura, Vaida, Carmen, Ciobotaru, Oana Roxana, Aignatoaie, Mariana, Carp, Cristina Paula, Cobzaru, Isabelle, Mardare, Oana, Purcarin, Bianca, Tutunaru, Valentin, Ionita, Victor, Arustei, Mirela, Codita, Anisoara, Busuioc, Mihai, Chilinciuc, Ion, Ciobanu, Cristina, Belciu, Ioana, Tincu, Eugen, Blaj, Mihaela, Grosu, Ramona-Mihaela, Sandu, Gigel, Bruma, Dana, Corneci, Dan, Dutu, Madalina, Krepil, Adriana, Copaciu, Elena, Dumitrascu, Clementina Oana, Jemna, Ramona, Mihaescu, Florentina, Petre, Raluca, Tudor, Cristina, Ursache, Elena, Kulikov, Alexander, Lubnin, Andrey, Grigoryev, Evgeny, Pugachev, Stanislav, Tolmasov, Alexander, Hussain, Ayyaz, Ilyina, Yana, Roshchina, Anna, Iurin, Aleksandr, Chazova, Elena, Dunay, Artem, Karelov, Alexey, Khvedelidze, Irina, Voldaeva, Olga, Belskiy, Vladislav, Dzhamullaev, Parvin, Grishkowez, Elena, Kretov, Vladimir, Levin, Valeriy, Molkov, Aleksandr, Puzanov, Sergey, Samoilenko, Aleksandr, Tchekulaev, Aleksandr, Tulupova, Valentina, Utkin, Ivan, Allorto, Nikki Leigh, Bishop, David Gray, Builu, Pierre Monji, Cairns, Carel, Dasrath, Ashish, de Wet, Jacque, den Hoedt, Marielle, Grey, Ben, Hayes, Morgan Philip, Küsel, Belinda Senta, Shangase, Nomcebo, Wise, Robert, Cacala, Sharon, Farina, Zane, Govindasamy, Vishendran, Kruse, Carl-Heinz, Lee, Carolyn, Marais, Leonard, Naidoo, Thinagrin Dhasarthun, Rajah, Chantal, Rodseth, Reitze Nil, Ryan, Lisa, von Rhaden, Richard, Adam, Suwayba, Alphonsus, Christella, Ameer, Yusuf, Anderson, Frank, Basanth, Sujith, Bechan, Sudha, Bhula, Chettan, Biccard, Bruce M., Biyase, Thuli, Buccimazza, Ine, Cardosa, Jorge, Chen, Jame, Daya, Bhavika, Drummond, Leanne, Elabib, Ali, Goad, Ehab Helmy Abdel, Goga, Ismail E., Goga, Riaz, Harrichandparsad, R., Hodgson, Richard E., Jordaan, J., Kalafatis, Nicky, Kampik, Christian, Landers, At, Loots, Emil, Madansein, Rajhmum, Madaree, Anil, Madiba, Thandinkosi E., Manzini, Vukani T., Mbuyisa, Mbali, Moodley, Rajan, Msomi, Mduduzi, Mukama, Innocent, Naidoo, Desigan, Naidoo, Rubeshan, Naidu, Tesuven K., Ntloko, Sindiswa, Padayachee, Eneshia, Padayachee, Lucelle, Phaff, Martijn, Pillay, Bala, Pillay, Desigan, Pillay, Lutchmee, Ramnarain, Anupa, Ramphal, Suren R., Ryan, Paul, Saloojee, Ahmed, Sebitloane, Motshedisi, Sigcu, Noluyolo, Taylor, Jenna L., Torborg, Alexandra, Visser, Linda, Anderson, Philip, Conradie, Alae, de Swardt, Mathew, de Villiers, Martin, Eikman, Johan, Liebenberg, Riaan, Mouton, Johan, Paton, Abbey, van der Merwe, Louwrence, Wilscott-Davids, Candice, Barrett, Wendy Joan, Bester, 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Delgado García, David R., Zamudio, Diana, Garcia Del Valle, Santiago, Luz Serrano, M., Alonso, Eduardo, Anillo, Victor, Maseda, Emilio, Salgado, Patricia, Suarez, Lui, Suarez-de-la-Rica, Alejandro, Villagrán, María José, Alonso, José Ignacio, Cabezuelo, Estefania, Garcia-Saiz, Irene, Lopez del Moral, Olga, Martín, Silvia, Perez Gonzalez, Alba, Tovar Doncel, Sherezade, Vera, Martin Agüero, Ávila Sánchez, Francisco José, Castaño, Beatriz, Castaño Moreira, Beatriz, Flores Risco, Sahely, Paz Martín, Daniel, Pérez Martín, Fernando, Poza, Paloma, Ruiz, Adela, Serna Martínez, Wilson Fabio, Vicente, Bárbara Vázquez, Dominguez, Saul Velaz, Fernández, Salvador, Munoz-López, Alfonso, Bernat, Maria Jose, Mas, Arantxa, Planas, Kenneth, Jawad, Monir, Saeed, Yousif, Hedin, Annika, Levander, Helena, Holmström, Sandra, Lönn, David, Zoerner, Frank, Åkring, Irene, Widmark, Carl, Zettergren, Jan, Liljequist, Victor Aspelund, Nystrom, Lena, Odeberg-Wernerman, Suzanne, Oldner, Ander, Reje, Patrik, Lyckner, 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Rachel, Costelloe, Hannah, Coxwell Matthewman, Madeline, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charle, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Cary, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thoma, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Robert, Stephen, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Hernandez, Miguel, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, Wilson, Debbie, Al-Soudaine, Yassr, Baldwin, Matthew, Cornish, Julie, Davies, Zoe, Davies, Leigh, Edwards, Marc, Frewer, Natasha, Gallard, Sian, Glasbey, Jame, Harries, Rhiannon, Hopkins, Luke, Kim, Taeyang, Koompirochana, Vilavan, Lawson, Simon, Lewis, Megan, Makzal, Zaid, Scourfield, Sarah, Ahmad, Yousra, Bates, Sarah, Blackwell, Clare, Bryant, Helen, Coulter, Suzanne, Cruickshank, Ro, Daniel, Sonya, Daubeny, Thoma, Edwards, Mark, Golder, Kim, Hawkins, Lesley, Helen, Bryant, Hinxman, Honor, Levett, Denny, Skinner, Ben, Walsgrove, Joseph, Dickson, Jane, Constantin, Kathryn, Karen, Markwell, O’Brien, Peter, O’Donohoe, Lynn, Payne, Hannah, Sundayi, Saul, Walker, Elaine, Brooke, Jenny, Cardy, Jon, Humphreys, Sally, Kessack, Laura, Kubitzek, Christiane, Kumar, Suha, Cotterill, Donna, Hodzovic, Emil, Hosdurga, Gurunath, Miles, Edward, Saunders, Glenn, Campbell, Marta, Chan, Peter, Jemmett, Kim, Raj, Ashok, Naik, Aditi, Ramamoorthy, Rajarajan, Shah, Nimesh, Sylvan, Axel, Blyth, Katharine, Burtenshaw, Andrew, Freeman, David, Johnson, Emily, Lo, Philip, Martin, Terry, Plunkett, Emma, Wollaston, Julie, Allison, Joanna, Carroll, Christine, Craw, Nichola, Craw, Sarah, Pitt-Kerby, Tressy, Rowland-Axe, Rebecca, Spurdle, Katie, McDonald, Andrew, Simon, Davie, Sinha, Vivek, Smith, Thoma, Banner-Goodspeed, Valerie, Boone, Myle, Campbell, Kathleen, Lu, Fengxin, Scannell, Joseph, Sobol, Julia, Balajonda, Naraida, Clemmons, Karen, Conde, Carlo, Funk, Bonita, Hall, Roger, Hopkins, Thoma, Olaleye, Omowunmi, Omer, Omer, Pender, Michelle, Porto, Angelo, Stevens, Alice, Waweru, Peter, Yeh, Erlinda, Bodansky, Daniella, Evans, Adam, Kleopoulos, Steven, Maril, Robert, Mathney, Edward, Sanchez, Angela, Tinuoye, Elizabeth, Bateman, Brian, Eng, Kristen, Jiang, Ning, Ladha, Karim, Needleman, Joseph, Chen, Lee-lynn, Lane, Rondall, Robinowitz, David, Ghushe, Neil, Irshad, Mariam, Patel, Samir, Takemoto, Steven, Wallace, Art, Mazzeffi, Michael, Rock, Peter, Wallace, Karin, Zhu, Xiaomao, Chua, Pandora, Mattera, Matthew, Sharar, Rebecca, Thilen, Stephan, Treggiari, Miriam, Morgan, Angela, Sofjan, Iwan, Subramaniam, Kathirvel, Avidan, Michael, Maybrier, Hannah, Muench, Maxwell, Wildes, Troy, Kahan, Bc, Koulenti, D, Arvaniti, K, Beavis, V, Campbell, D, Chan, M, Moreno, R, Pearse RM (International Surgical Outcomes Study (ISOS), group), Zangrillo, A, Landoni, G, Beretta, L., Anesthesiology research group, Supporting clinical sciences, Intensive care medicine, International Surgical Outcomes Study (ISOS) group, Pearse, R.M., Beattie, S., Clavien, P.A., Demartines, N., Fleisher, L.A., Grocott, M., Haddow, J., Hoeft, A., Holt, P., Moreno, R., Pritchard, N., Rhodes, A., Wijeysundera, D., Wilson, M., Ahmed, T., Everingham, K., Hewson, R., Januszewska, M., Phull, M.K., Halliwell, R., Shulman, M., Myles, P., Schmid, W., Hiesmayr, M., Wouters, P., de Hert, S., Lobo, S., Fang, X., Rasmussen, L., Futier, E., Biais, M., Venara, A., Slim, K., Sander, M., Koulenti, D., Arvaniti, K., Chan, M., Kulkarni, A., Chandra, S., Tantri, A., Geddoa, E., Abbas, M., Della Rocca, G., Sivasakthi, D., Mansor, M., Luna, P., Bouwman, A., Buhre, W., Beavis, V., Campbell, D., Short, T., Osinaike, T., Matos, R., Grigoras, I., Kirov, M., Protsenko, D., Biccard, B., Aldecoa, C., Chew, M., Hofer, C., Hubner, M., Ditai, J., Szakmany, T., Fleisher, L., Ferguson, M., MacMahon, M., Cherian, R., Currow, H., Kanathiban, K., Gillespie, D., Pathmanathan, E., Phillips, K., Reynolds, J., Rowley, J., Douglas, J., Kerridge, R., Garg, S., Bennett, M., Jain, M., Alcock, D., Terblanche, N., Cotter, R., Leslie, K., Stewart, M., Zingerle, N., Clyde, A., Hambidge, O., Rehak, A., Cotterell, S., Binh Quan Huynh, W., McCulloch, T., Ben-Menachem, E., Egan, T., Cope, J., Fellinger, P., Haselberger, S., Holaubek, C., Lichtenegger, P., Scherz, F., Hoffer, F., Cakova, V., Eichwalder, A., Fischbach, N., Klug, R., Schneider, E., Vesely, M., Wickenhauser, R., Grubmueller, K.G., Leitgeb, M., Lang, F., Toro, N., Bauer, M., 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Al-Soudaine, Y., Baldwin, M., Cornish, J., Davies, Z., Davies, L., Edwards, M., Frewer, N., Gallard, S., Glasbey, J., Harries, R., Hopkins, L., Kim, T., Koompirochana, V., Lawson, S., Lewis, M., Makzal, Z., Scourfield, S., Ahmad, Y., Bates, S., Blackwell, C., Bryant, H., Coulter, S., Cruickshank, R., Daniel, S., Daubeny, T., Golder, K., Hawkins, L., Helen, B., Hinxman, H., Levett, D., Skinner, B., Walsgrove, J., Dickson, J., Constantin, K., Karen, M., O'Brien, P., O'Donohoe, L., Payne, H., Sundayi, S., Walker, E., Brooke, J., Cardy, J., Humphreys, S., Kessack, L., Kubitzek, C., Kumar, S., Cotterill, D., Hodzovic, E., Hosdurga, G., Miles, E., Saunders, G., Campbell, M., Chan, P., Jemmett, K., Raj, A., Naik, A., Ramamoorthy, R., Shah, N., Sylvan, A., Blyth, K., Burtenshaw, A., Freeman, D., Johnson, E., Lo, P., Martin, T., Plunkett, E., Wollaston, J., Allison, J., Carroll, C., Craw, N., Craw, S., Pitt-Kerby, T., Rowland-Axe, R., Spurdle, K., McDonald, A., Simon, D., Sinha, V., Banner-Goodspeed, V., Boone, M., Campbell, K., Lu, F., Scannell, J., Sobol, J., Balajonda, N., Clemmons, K., Conde, C., Funk, B., Hopkins, T., Olaleye, O., Omer, O., Pender, M., Porto, A., Waweru, P., Yeh, E., Bodansky, D., Evans, A., Kleopoulos, S., Maril, R., Mathney, E., Sanchez, A., Tinuoye, E., Bateman, B., Eng, K., Jiang, N., Ladha, K., Needleman, J., Chen, L.L., Lane, R., Robinowitz, D., Ghushe, N., Irshad, M., Patel, S., Takemoto, S., Wallace, A., Mazzeffi, M., Rock, P., Wallace, K., Zhu, X., Chua, P., Mattera, M., Sharar, R., Thilen, S., Treggiari, M., Morgan, A., Sofjan, I., Subramaniam, K., Avidan, M., Maybrier, H., Muench, M., and Wildes, T.
Subjects: Male, HSJ UCI, Critical Care and Intensive Care Medicine, law.invention, Perioperative Care/methods, 0302 clinical medicine, Surgical procedures, 030202 anesthesiology, law, Critical care/utilisation, Postoperative care/methods, Postoperative care/statistics and numerical data, Surgical procedures, operative/mortality, statistics and numerical data, Prospective Studies, Postoperative Period, Postoperative care/methods, education.field_of_study, Postoperative care/method, Elective Surgical Procedures/mortality, fluid output, Middle Aged, fluid administration, Intensive care unit, Hospitalization, Length of Stay/statistics & numerical data, operative/mortality, Intensive Care Units/statistics & numerical data, outcome, Female, Elective Surgical Procedure, Human, Adult, medicine.medical_specialty, Logistic Model, Postoperative care/statistics and numerical data, Critical care/utilisation, Population, Intensive Care Unit, Elective Surgical Procedures/statistics & numerical data, Hospitalization/statistics & numerical data, Humans, Logistic Models, Surgical procedures, operative/mortality, Postoperative care, methods, Perioperative Care, NO, 03 medical and health sciences, Anesthesiology, Intensive care, medicine, Elective surgery, Intensive care medicine, education, business.industry, 030208 emergency & critical care medicine, Perioperative, Length of Stay, Clinical trial, Prospective Studie, septic shock, business
Abstract: PURPOSE: As global initiatives increase patient access to surgical treatments, there is a need to define optimal levels of perioperative care. Our aim was to describe the relationship between the provision and use of critical care resources and postoperative mortality. METHODS: Planned analysis of data collected during an international 7-day cohort study of adults undergoing elective in-patient surgery. We used risk-adjusted mixed-effects logistic regression models to evaluate the association between admission to critical care immediately after surgery and in-hospital mortality. We evaluated hospital-level associations between mortality and critical care admission immediately after surgery, critical care admission to treat life-threatening complications, and hospital provision of critical care beds. We evaluated the effect of national income using interaction tests. RESULTS: 44,814 patients from 474 hospitals in 27 countries were available for analysis. Death was more frequent amongst patients admitted directly to critical care after surgery (critical care: 103/4317 patients [2%], standard ward: 99/39,566 patients [0.3%]; adjusted OR 3.01 [2.10-5.21]; p < 0.001). This association may differ with national income (high income countries OR 2.50 vs. low and middle income countries OR 4.68; p = 0.07). At hospital level, there was no association between mortality and critical care admission directly after surgery (p = 0.26), critical care admission to treat complications (p = 0.33), or provision of critical care beds (p = 0.70). Findings of the hospital-level analyses were not affected by national income status. A sensitivity analysis including only high-risk patients yielded similar findings. CONCLUSIONS: We did not identify any survival benefit from critical care admission following surgery. info:eu-repo/semantics/publishedVersion
Published: 2017
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30 results on '"Du, Fang"'

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3. Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation

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9. Analysis of Heart Rate Variability and Cardiac Autonomic Nerve Remodeling in Streptozotocin-induced Diabetic Rats

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13. Transmission spectra of one-dimensional photonic crystals including negative-refractive-index media

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15. Properties of defect mode and optical enhancement of 1D photonic crystals with a defect layer of negative refractive index material

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17. GW27-e0800 Cardiac Dysregulation and Myocardial Injury in a 6-Hydroxydopamine-Induced Rat Model of Sympathetic Denervation and Prevention effect of Guizhi Decoction

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19. Investigation and analysis on the adverse reactions caused by 12 kinds of commonly used traditional Chinese medicine injections

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21. Optical transmission properties of Bragg microcavity containing left handed materials

22. Optical bistable behavior involving photonic crystals nonlinear cavity

23. Optimal bistable switching in photonic crystals with defect of nonlinear dielectric materials

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26. Measurement of optical fiber dispersion slope and self-phase modulation effect using fast Fourier transform

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28. Migration studies on esophageal precancerous and cancerous lesions in Linxian, China

29. Polarization properties of one-dimensional photonic crystal tunneling mode containing metamaterials

30. Critical care admission following elective surgery was not associated with survival benefit

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