Search

Background To determine the proportion of patients in symptomatic remission and recovery following a first-episode of psychosis (FEP). Methods A multistep literature search using the Web of Science database, Cochrane Central Register of Reviews, Ovid/PsychINFO, and trial registries from database inception to November 5, 2020, was performed. Cohort studies and randomized control trials (RCT) investigating the proportion of remission and recovery following a FEP were included. Two independent researchers searched, following PRISMA and MOOSE guidelines and using a PROSPERO protocol. We performed meta-analyses regarding the proportion of remission/recovery (symptomatic plus functional outcomes). Heterogeneity was measured employing Q statistics and I2 test. To identify potential predictors, meta-regression analyses were conducted, as well as qualitative reporting of studies included in a systematic review. Sensitivity analyses were performed regarding different times of follow-up and type of studies. Results One hundred articles (82 cohorts and 18 RCTs) were included in the meta-analysis. The pooled proportion of symptomatic remission was 54% (95%CI [30, 49–58]) over a mean follow-up period of 43.57 months (SD = 51.82) in 76 studies. After excluding RCT from the sample, the proportion of remission remained similar (55%). The pooled proportion of recovery was 32% (95%CI [27–36]) over a mean follow-up period of 71.85 months (SD = 73.54) in 40 studies. After excluding RCT from the sample, the recovery proportion remained the same. No significant effect of any sociodemographic or clinical predictor was found. Conclusions Half of the patients are in symptomatic remission around 4 years after the FEP, while about a third show recovery after 5.5 years.

Background: The COVID-19 pandemic has been a global challenge. High mortality rates have been reported in some risk groups, including patients with pre-existing mental disorders. This study aimed to analyse the COVID-19 mortality risk and hospital admissions in patients with psychiatric disorders. Methods: We used retrospectively electronic health records (EHR) to identify people infected due to COVID-19 between the 14th of March 2020 to the 14th of March 2021) in the three territories of the Basque Country. Univariable and multivariable logistic regression models and multilevel analyses with generalized estimated equations were used to study the role of factors associated with mortality or with hospital admission, including the Basque Country territory-level random effect. Outcomes: The COVID-19 mortality rate was increased in patients with psychotic disorders (OR unadjusted: 8∙10, 95%CI [6∙53, 10∙05]