15 results on '"Benita Hermanns-Sachweh"'
Search Results
2. Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis
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Joerg S. Sachweh, Adelin Albert, Peter Nils Liersch, Andreas Schwarz, Jaime F. Vazquez-Jimenez, Benita Hermanns-Sachweh, Marie-Christine Seghaye, and Ruth Heying
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Pathology ,medicine.medical_specialty ,Apoptosis ,Real-Time Polymerase Chain Reaction ,Muscle hypertrophy ,Fibrosis ,Gene expression ,medicine ,Animals ,Ventricular remodeling ,Sheep ,business.industry ,Myocardium ,Gene Expression Regulation, Developmental ,DNA ,medicine.disease ,Pathophysiology ,Pulmonary Valve Stenosis ,Disease Models, Animal ,Microscopy, Electron ,Stenosis ,Animals, Newborn ,Pulmonary valve stenosis ,Cytokines ,Intercellular Signaling Peptides and Proteins ,Molecular Medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
ABSTRACT Background: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified. Methods: Six newborn lambs underwent pulmonary arterial banding, seven sham operation. mRNA encoding for cytokines, growth factors and regulators of apoptosis was sequentially measured in myocardium and blood before and up to 12 weeks postoperatively. Results: Experimental animals showed hypertrophy and fibrosis of the right ventricular myocardium, myocardial over-expression of CT-1-mRNA and higher blood concentrations of mRNA encoding for VEGF, TGF-β, Bak and BcL-xL than controls, respectively. Conclusion: Neonatal pulmonary stenosis leads to myocardial hypertrophy that is associated with CT-1 gene expression and with activation of growth- and apoptosis pathways in blood cells.
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- 2015
3. Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes
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Christoph Jan Wruck, Mary B. Goldring, Nisreen Kweider, Lars Ove Brandenburg, Mersedeh Tohidnezhad, Benita Hermanns-Sachweh, Holger Jahr, Astrid Houben, Rainer Beckmann, Thomas Pufe, and Athanassios Fragoulis
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Cartilage, Articular ,Vascular Endothelial Growth Factor A ,Pathology ,Time Factors ,Angiogenesis ,C-28/I2 ,VEGF-A ,lcsh:Chemistry ,chemistry.chemical_compound ,0302 clinical medicine ,Genes, Reporter ,Promoter Regions, Genetic ,Receptor ,lcsh:QH301-705.5 ,Cells, Cultured ,sVEGFR-1/FLT-1 ,Spectroscopy ,Regulation of gene expression ,0303 health sciences ,cyclic stretch ,General Medicine ,Computer Science Applications ,Cell biology ,Vascular endothelial growth factor ,Vascular endothelial growth factor A ,medicine.anatomical_structure ,VEGFR-1/FLT-1 ,strain ,human chondrocyte ,medicine.medical_specialty ,Primary Cell Culture ,Enzyme-Linked Immunosorbent Assay ,In Vitro Techniques ,Article ,Catalysis ,Cell Line ,Inorganic Chemistry ,03 medical and health sciences ,Chondrocytes ,medicine ,Humans ,Physical and Theoretical Chemistry ,Cell Shape ,Molecular Biology ,030304 developmental biology ,030203 arthritis & rheumatology ,Vascular Endothelial Growth Factor Receptor-1 ,business.industry ,Cartilage ,Organic Chemistry ,In vitro ,Gene Expression Regulation ,lcsh:Biology (General) ,lcsh:QD1-999 ,chemistry ,Cell culture ,Microscopy, Electron, Scanning ,Stress, Mechanical ,business - Abstract
International journal of molecular sciences 15(9), 15456-15474 (2014). doi:10.3390/ijms150915456, Published by Molecular Diversity Preservation International, Basel
- Published
- 2014
4. Purely cancellous vs. corticocancellous bone in sinus floor augmentation with autogenous iliac crest: a prospective clinical trial
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Hubertus Spiekermann, Marcus Gerressen, Ralf-Dieter Hilgers, Alireza Ghassemi, Dieter Riediger, and Benita Hermanns-Sachweh
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Adult ,Male ,Sinus Floor Augmentation ,medicine.medical_specialty ,Bone density ,Biopsy ,Bone Matrix ,Dentistry ,Osteocytes ,Transplantation, Autologous ,Iliac crest ,Ilium ,Sex Factors ,Bone Density ,Osteogenesis ,Maxilla ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Aged ,Bone Transplantation ,Osteoblasts ,business.industry ,Age Factors ,Alveolar Ridge Augmentation ,Maxillary Sinus ,Middle Aged ,Surgery ,Transplantation ,medicine.anatomical_structure ,Tissue and Organ Harvesting ,Female ,Cortical bone ,Bone Remodeling ,Implant ,Atrophy ,Oral Surgery ,business ,Cancellous bone - Abstract
Objectives: Among the different graft materials being applied in sinus elevation surgery autogenous bone, especially from the iliac crest, is considered to be the graft of choice. The goal of this prospective study was to investigate whether purely cancellous transplants of this donor site lead to significantly better results regarding bone quantity and quality when compared to corticocancellous iliac bone grafts. Material and methods: Fifteen patients suffering from extreme maxillary atrophy underwent bilateral sinus floor augmentation with grafts from the iliac crest consisting of purely cancellous bone (PCB) for the right side and a mixture of 50% cancellous and 50% cortical bone for the left side, respectively. Bone samples that were taken during implant insertion were examined histologically for semiquantitative assessment. In addition, bone density was measured histomorphometrically. Data were statistically analyzed by a repeated measures analysis of covariance model and post hoc paired t-tests as well as Pearson's correlation analysis. Results: Semiquantitative analysis of bone quality resulted in comparable results for both graft preparations while bone density was significantly higher in the PCB group. Without consideration of the different transplant groups, there was neither a significant correlation between patients' age and bone density nor bone quality. Differences between the genders could not be observed either. Conclusions: Because of better bone density, the PCB graft from the iliac crest remains our gold standard. Even in elderly patients, autogenous grafts can be utilized without losses in the properties of the resulting bone.
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- 2009
5. Corrigendum to 'Enoxaparin Prevents Steroid-Related Avascular Necrosis of the Femoral Head'
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Nisreen Kweider, Alireza Ghassemi, Wolf Drescher, Benita Hermanns-Sachweh, Hayfaa Shaheen, Athanassios Fragoulis, Thomas Pufe, Mamed Kadyrov, and Rainer Beckmann
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Male ,medicine.medical_specialty ,lcsh:Medicine ,Avascular necrosis ,Bioinformatics ,Chemoprevention ,Osteocytes ,lcsh:Technology ,General Biochemistry, Genetics and Molecular Biology ,Femoral head ,Femur Head Necrosis ,medicine ,Animals ,Enoxaparin ,lcsh:Science ,General Environmental Science ,business.industry ,lcsh:T ,lcsh:R ,Anticoagulants ,General Medicine ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Steroids ,lcsh:Q ,Rabbits ,business ,Corrigendum - Abstract
The ScientificWorld journal 2015, 264241 (2015). doi:10.1155/2015/264241, Published by The Scientific World, Boynton Beach, Fla.
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- 2015
6. Epithelioid sarcoma in the thoracic spine
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Christian H. Siebert, Benita Hermanns-Sachweh, M. Weisskopf, Ralph Münker, and J. A. K. Ohnsorge
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Male ,medicine.medical_specialty ,Soft Tissue Neoplasm ,Adolescent ,Survival ,Biopsy ,Epithelioid sarcoma ,Soft Tissue Neoplasms ,Case Report ,Nodular fasciitis ,Thoracic Vertebrae ,Metastasis ,medicine ,Adjuvant therapy ,Humans ,Neoplasm Invasiveness ,Orthopedic Procedures ,Orthopedics and Sports Medicine ,Postoperative Period ,Spinal Neoplasms ,medicine.diagnostic_test ,business.industry ,Sarcoma ,medicine.disease ,Magnetic Resonance Imaging ,Orthopedic Fixation Devices ,Surgery ,Spinal Fusion ,medicine.anatomical_structure ,Positron-Emission Tomography ,Thoracic vertebrae ,Radiography, Thoracic ,Radiology ,Neoplasm Recurrence, Local ,Thoracic spine ,business ,Follow-Up Studies - Abstract
Epithelioid sarcoma is a rare and highly malignant soft tissue tumor that is commonly found in the extremities and rarely in the trunk area. This malignant tumor often mimics granuloma or nodular fasciitis, which causes a delay in establishing the diagnosis. This type of cancer has a high recurrence rate. Surgical treatment requires wide radical resection. The objective of this case report is to highlight the unique location of a rare neoplasm and to illustrate the relentless course of epithelioid sarcoma despite initial radical resection. A 14-year-old boy was admitted to our facility with a soft tissue mass on the right lower thoracic spine. The large tumor mass had deeply penetrated into the muscles, infiltrated the neuroforamen of T9–T10 level, and compressed the dural sac. Immunohistological study of the biopsy was highly consistent with an epithelioid sarcoma. Wide excision of the mass, laminectomy and spine fusion with instrumentation was performed. The patient received chemotherapy and irradiation. The first recurrence of the neoplasm was seen as a contralateral metastasis 21 months after the resection. On the last follow-up, 3 years postoperatively, the patient was in a good general condition. However, further progression of the sarcoma had to be recognized. Our case encompasses multiple features that represent negative prognostic factors. Initial wide excision of the neoplasm and adjuvant therapy including chemotherapy and irradiation seem to slow down the relentless course of epithelioid sarcoma in the trunk.
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- 2006
7. Vascular changes in the periosteum of congenital pseudarthrosis of the tibia
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Bernd Klosterhalfen, Benita Hermanns-Sachweh, Joachim Alfer, Jan Senderek, László Füzesi, Marc Weber, and Reinhard Büttner
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Male ,Pathology ,medicine.medical_specialty ,Neurofibromatosis 1 ,Skin Neoplasms ,Adolescent ,Pathology and Forensic Medicine ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Microscopy, Electron, Transmission ,Periosteum ,Congenital pseudarthrosis ,Mechanical strength ,Humans ,Medicine ,Tibia ,Neurofibromatosis ,Child ,neoplasms ,030222 orthopedics ,business.industry ,Arteries ,030229 sport sciences ,Cell Biology ,Anatomy ,medicine.disease ,3. Good health ,Tibial Fractures ,Pseudarthrosis ,medicine.anatomical_structure ,Etiology ,Immunohistochemistry ,Female ,business - Abstract
The etiology and the pathogenesis of congenital pseudarthrosis of the tibia (CPT) are still unknown. The affected tibia exhibits insufficient mechanical strength and osteogenetic capability. CPT is frequently associated with neurofibromatosis type 1 (NF1; von Recklinghausen's disease); however, both diseases have not yet been linked pathogenetically. This study presents the pathomorphologic findings of CPT under special consideration of NF1. Therefore, samples from patients operated on for CPT (n = 4) with (n = 3) and without (n = 1) neurofibromatosis were investigated by light microscopy, immunohistochemistry, and electron microscopy. The most striking finding in all patients was thickened periosteum with accumulation of nerval cells surrounding small arteries, causing subtotal or complete obliteration. In conclusion, impaired vascularization can result in decreased osteogenic capabilities. The similarity of ultrastructural findings in the abnormal periosteum and in skin neurofibromas of neurofibromatosis patients may indicate a pathogenetic association of both diseases.
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- 2005
8. Endoglin (CD105) expression differentiates between aseptic loosening and periprosthetic joint infection after total joint arthroplasty
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Benita Hermanns-Sachweh, Thomas M. Randau, Philipp Jansen, Sascha Gravius, and Torsten Mumme
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Pathology ,medicine.medical_specialty ,Multidisciplinary ,business.industry ,Research ,Periprosthetic membrane ,Endoglin ,Periprosthetic ,Histopathology ,Inflammation ,medicine.disease ,Neovascularization ,Pathogenesis ,Fibrosis ,Periprosthetic joint infection ,Total joint arthroplasty ,Immunohistochemistry ,Medicine ,Aseptic loosening ,medicine.symptom ,business ,ddc:600 - Abstract
The differentiation between aseptic loosening and periprosthetic joint infection (PJI) after total joint arthroplasty is essential for successful therapy. A better understanding of pathogenesis of aseptic loosening and PJI may help to prevent or treat these complications. Previous investigations revealed an increased vascularization in the periprosthetic membrane in cases of PJI via PET signals. Based on these findings our hypothesis was that PJI is associated with an increased neovascularization in the periprosthetic membrane. Tissue samples from periprosthetic membranes of the bone-implant interface were investigated histologically for inflammation, wear particles, vascularization and fibrosis. To identify vascular structures antibodies against CD 31, CD 34, factor VIII and CD 105 (endoglin) were applied for immunohistochemical investigations. According to a consensus classification of Morawietz the tissue samples were divided into four types: type I (wear particle induced type, n = 11), type II (infectious type, n = 7), type III (combined type, n = 7) and type IV (indeterminate type, n = 7). Patients with PJI (type II) showed a pronounced infiltration of neutrophil granulocytes in the periprosthetic membrane and an enhanced neovascularization indicated by positive immunoreaction with antibodies against CD 105 (endoglin). Tissue samples classified as type I, type III and type IV showed significantly less immune reaction for CD 105. In cases of aseptic loosening and PJI vascularization is found in different expression in periprosthetic membranes. However, in aseptic loosening, there is nearly no neovascularization with CD 105-positive immune reaction. Therefore, endoglin (CD 105) expression allows for differentiation between aseptic loosening and PJI.
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- 2014
9. Enoxaparin Prevents Steroid-Related Avascular Necrosis of the Femoral Head
- Author
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Alireza Ghassemi, Athanassios Fragoulis, Rainer Beckmann, Thomas Pufe, Benita Hermanns-Sachweh, Hayfaa Shaheen, Mamed Kadyrov, Wolf Drescher, and Nisreen Kweider
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medicine.medical_specialty ,Article Subject ,medicine.medical_treatment ,lcsh:Medicine ,Avascular necrosis ,lcsh:Technology ,General Biochemistry, Genetics and Molecular Biology ,Hip replacement (animal) ,Femoral head ,medicine ,Thrombus ,lcsh:Science ,Saline ,General Environmental Science ,lcsh:T ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Methylprednisolone ,Orthopedic surgery ,lcsh:Q ,business ,Glucocorticoid ,Research Article ,medicine.drug - Abstract
Scientific world journal 2014, 347813 (2014). doi:10.1155/2014/347813, Published by Boynton Beach, Fla.
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- 2014
- Full Text
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10. Wireless blood pressure monitoring with a novel implantable device: long-term in vivo results
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Anna Woitok, Nina J. Cleven, Ulrich Steinseifer, Peter Isfort, Thomas Schmitz-Rode, Tobias Penzkofer, and Benita Hermanns-Sachweh
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medicine.medical_specialty ,Femoral artery ,medicine.artery ,medicine ,Animals ,Telemetry ,Radiology, Nuclear Medicine and imaging ,Thrombus ,Miniaturization ,Sheep ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Angiography ,Equipment Design ,Blood Pressure Monitoring, Ambulatory ,medicine.disease ,Pressure sensor ,Surgery ,Pulse pressure ,Femoral Artery ,Catheter ,Blood pressure ,Fluoroscopy ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomedical engineering - Abstract
Devices constantly tracking the blood pressure (BP) of hypertensive patients are highly desired to facilitate effective patient management and to reduce hospitalization. We report on experiences gathered in a pilot study that was designed to evaluate the prototype of a newly developed, minimally invasive implantable sensor system for long-term BP monitoring. The device was implanted in the femoral artery (FA) of 12 sheep via standard FA catheterization under fluoroscopic control. Accuracy of the recorded blood pressure was determined by comparison with a reference catheter, which was positioned in the contralateral FA immediately after implantation. Regular follow-up included angiography, computed tomography (CT), and control of functionality and position of the BP sensor. Animals were euthanized after 6 months. FA segments with in situ pressure sensor underwent macroscopic and histopathologic examinations. All implantations of the novel sensor device in the FA were successful and uneventful. High-quality BP recordings were documented. Bland–Altman plots indicate very good agreement. Comparison with measurements taken from the reference sensor revealed mean differences and standard deviations of −0.56 ± 0.85, 0.29 ± 1.44, and 0.85 ± 2.27 mmHg (diastolic, systolic, and pulse pressure, respectively) after exclusion of one outlier. CT uncovered deficiencies in cable stability that were addressed in a redesign. No thrombus formation, necrosis, or apoptosis were detected. The pilot study proved the technical feasibility of wireless BP measurement in the FA via a novel miniature sensor device.
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- 2013
11. A new biphasic osteoinductive calcium composite material with a negative Zeta potential for bone augmentation
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Oliver Driemel, Marcus Gerressen, Jamal M. Stein, Dieter Riediger, Oliver Maciejewski, Benita Hermanns-Sachweh, Ralf Smeets, and Andreas Kolk
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Sinus Floor Augmentation ,lcsh:Specialties of internal medicine ,Bone density ,Maxillary sinus ,Clinical Neurology ,Dentistry ,chemistry.chemical_element ,Calcium ,Osseointegration ,lcsh:RC581-951 ,Bone Density ,Paranasal Sinus Diseases ,Medicine ,Humans ,Surface charge ,Composite material ,Bone regeneration ,General Dentistry ,business.industry ,Dentistry(all) ,Methodology ,Maxillary Sinus ,Middle Aged ,medicine.anatomical_structure ,chemistry ,Otorhinolaryngology ,Bone Substitutes ,Female ,Neurology (clinical) ,Implant ,business - Abstract
The aim of the present study was to analyze the osteogenic potential of a biphasic calcium composite material (BCC) with a negative surface charge for maxillary sinus floor augmentation. In a 61 year old patient, the BCC material was used in a bilateral sinus floor augmentation procedure. Six months postoperative, a bone sample was taken from the augmented regions before two titanium implants were inserted at each side. We analyzed bone neoformation by histology, bone density by computed tomography, and measured the activity of voltage-activated calcium currents of osteoblasts and surface charge effects. Control orthopantomograms were carried out five months after implant insertion. The BCC was biocompatible and replaced by new mineralized bone after being resorbed completely. The material demonstrated a negative surface charge (negative Zeta potential) which was found to be favorable for bone regeneration and osseointegration of dental implants.
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- 2008
12. Congenital cystic adenomatoid malformation type 0-a rare cause of neonatal death
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Benita Hermanns-Sachweh, Jörg S. Sachweh, Marie-Christine Seghaye, Stefan Stuhrmann, Jaime F. Vazquez-Jimenez, and Lutz Bindl
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medicine.medical_specialty ,medicine.medical_treatment ,Critical Care and Intensive Care Medicine ,Pulmonary function testing ,Extracorporeal Membrane Oxygenation ,Fatal Outcome ,Cystic Adenomatoid Malformation of Lung, Congenital ,Intensive Care Units, Neonatal ,Extracorporeal membrane oxygenation ,medicine ,Humans ,Treatment Failure ,Lung ,Pediatric intensive care unit ,business.industry ,Infant, Newborn ,Prognosis ,Surgery ,medicine.anatomical_structure ,Respiratory failure ,Pediatrics, Perinatology and Child Health ,Congenital Cystic Adenomatoid Malformation ,Female ,Neonatal death ,Differential diagnosis ,business ,Respiratory Insufficiency - Abstract
Objective We give the first account of failure of extracorporeal membrane oxygenation therapy secondary to congenital cystic malformation of the lung (CCAM) type 0. Design Case report. Setting Pediatric intensive care unit. Patient A female neonate, appropriate for gestational age, with respiratory failure immediately after delivery. Interventions : Cardiopulmonary support with venoarterial extracorporeal membrane oxygenation. Results There was no improvement of pulmonary function, and the patient died. CCAM type 0 was diagnosed postmortem. Conclusions CCAM type 0 should be considered as a rare differential diagnosis of irreversible lung pathologies leading to failure of extracorporeal membrane oxygenation therapy for neonatal respiratory failure.
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- 2007
13. Anchorage efficacy of palatally-inserted miniscrews in molar distalization with a periodontally/miniscrew-anchored distal jet
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Norbert Gülden, Benita Hermanns-Sachweh, Peter Diedrich, Gero Kinzinger, and Faruk Yildizhan
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Molar ,Dental Stress Analysis ,Male ,Periodontium ,Materials science ,Tooth Movement Techniques ,Cephalometry ,Bone Screws ,Anterior cranial ,Dentistry ,Orthodontics ,Anterior region ,Palatal plane ,Orthodontic Anchorage Procedures ,Humans ,Orthodontic Appliance Design ,Patient compliance ,Child ,Titanium ,business.industry ,Palate ,Molar distalization ,Female ,Oral Surgery ,business - Abstract
As a clinical pilot study using the skeletonized, periodontally/miniscrew-anchored Distal Jet appliance, this study aimed to verify the positional stability of the palatally-inserted paramedian miniscrews when subjected to loading for several months, hence to assess the efficacy of the supporting anchorage design.Sixteen miniscrews (8-9 mm in length, 1.6 mm in diameter, polished surface) were inserted in the anterior region of the palate at paramedian locations. Once they had been in place for 1 week, skeletonized Distal Jets for bilateral molar distalization were anchored to the first premolars and necks of the miniscrews using composite. The appliances' coil spring systems were activated to a distalization force of 200-240 cN. The miniscrews were processed histologically after minimally-invasive explantation.Forces acting reciprocally on the anchorage unit result in significant anchorage loss in the palatally-inserted titanium miniscrews used for added anchorage support: we observed ventral movement in the vicinity of the miniscrew heads of 0.95+/-0.82 mm (the mean; p = 0.005), and extrusion of 0.21+/-0.28 mm (p = 0.040). In the process they tipped 2.65 degrees +/-6.23 degrees in relation to the palatal plane and 2.15 degrees +/-5.76 degrees in relation to the anterior cranial base. We observed no evidence of direct screw-to-bone contact in any of the explanted miniscrews.Titanium miniscrews with a polished surface, 1.6 mm in diameter and 8-9 mm long, do not provide stationary anchorage in molar distalization with the periodontally/miniscrew-anchored Distal Jet. When subjected for several months to load from forces that act in reciprocity to the force systems occurring during molar distalization, they fail to remain completely stationary in position in the palatal locations in which they were inserted. However, the combined anchorage setup is sufficient, intraorally and regardless of patient compliance, to largely compensate for the mesially-acting forces that occur reciprocal to molar distalization.
- Published
- 2007
14. Amphiphilic bonder improves adhesion at the acrylic bone cement-bone interface of cemented acetabular components in total hip arthroplasty: in vivo tests in an ovine model
- Author
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Dieter Christian Wirtz, Stefan Andereya, Torsten Mumme, S. Gravius, Christian Siebert, Benita Hermanns-Sachweh, Rudolf Marx, and Ralf Müller-Rath
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musculoskeletal diseases ,Joint Instability ,medicine.medical_specialty ,Radiodensity ,medicine.medical_treatment ,Radiography ,Arthroplasty, Replacement, Hip ,Total hip replacement ,Prosthesis Implantation ,Adhesion (medicine) ,Prosthesis Design ,Sensitivity and Specificity ,Random Allocation ,Osteogenesis ,Reference Values ,Risk Factors ,medicine ,Animals ,Polymethyl Methacrylate ,Orthopedics and Sports Medicine ,Cementation ,Sheep, Domestic ,Fixation (histology) ,Probability ,Analysis of Variance ,business.industry ,Acetabulum ,General Medicine ,equipment and supplies ,medicine.disease ,Arthroplasty ,Immunohistochemistry ,Surgery ,Disease Models, Animal ,surgical procedures, operative ,Orthopedic surgery ,Female ,Hip Prosthesis ,business ,Biomedical engineering - Abstract
Even following the introduction of the “third generation” cementing technique, an improvement of the fixation of the acetabular component similar to that of the femoral has not been shown in clinical studies. The goal of the present study was to achieve a better stability with the use of an amphiphilic bonder while preserving the mechanically important subchondral sclerosis. In a total of 20 sheep, a cemented total hip replacement was implanted. In the treatment group (n = 10), the implantation was carried out following surface conditioning of the acetabular bed with an amphiphilic bonder. All the sheep were followed for 9 months. To assess the biocompatibility, the osseous ingrowth at the cement–bone interface was depicted with the help of an in vivo fluorescent marking of the osteoblasts. Additionally, conventional radiographs were obtained over the course of treatment. Finally, the ovine pelvic regions were split following a standardized technique allowing for histological evaluation of the cement–bone interfaces. The acetabular components of the treatment group revealed a stable cement–bone compound. In the control group, the implants were easily dislodged from their beds. This finding was consistent with the radiological and histological results, which had revealed increased, progressive lytic radiolucent lines and the interposition of fibrous tissue at the cement–bone interface in the control group compared to the treatment group. The bonder was biocompatible. Following the application of the bonder, the cemented acetabular components revealed an improved stability without signs of inflammation or neoplasia in a viable acetabular osseous bed. With the help of this technique, the in vivo longevities of cemented acetabular components can be increased in the clinical setting without sacrificing the biomechanical relevant subchondral sclerosis.
- Published
- 2007
15. Long-term histological and scanning electron microscopy results of endovascular and operative treatments of experimentally induced aneurysms in the rabbit
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Manfred Bovi, K. Scherer, Timo Krings, Claudia Busch, Franz J. Hans, Bernd Sellhaus, Benita Hermanns-Sachweh, Armin Thron, Angela Y Drexler, and Joachim M. Gilsbach
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Carotid Artery Diseases ,medicine.medical_specialty ,Time Factors ,Carotid Artery, Common ,medicine.medical_treatment ,Constriction, Pathologic ,Neurosurgical Procedures ,Aneurysm ,Blood vessel prosthesis ,medicine ,Animals ,cardiovascular diseases ,Embolization ,Postoperative Period ,Wound Healing ,medicine.diagnostic_test ,Pancreatic Elastase ,business.industry ,Stent ,Intracranial Aneurysm ,Thrombosis ,Clipping (medicine) ,medicine.disease ,Embolization, Therapeutic ,Surgery ,Blood Vessel Prosthesis ,Cerebral Angiography ,Stenosis ,Angiography ,cardiovascular system ,Microscopy, Electron, Scanning ,Stents ,Neurology (clinical) ,Radiology ,Endothelium, Vascular ,Rabbits ,business ,Cerebral angiography - Abstract
Objective Treatment strategies of cerebral aneurysms include surgical clipping and endovascular therapies. To determine the long-term results of these therapeutic strategies, the vessel wall reaction close to the former aneurysm was studied according to the assumption that an intact endothelial layer over the former aneurysm neck constitutes complete vessel wall reconstruction and stable aneurysm obliteration. Methods Aneurysms were created in 40 rabbits by intraluminal elastase incubation of the common carotid artery. Five animals each were assigned to the following groups: untreated, porous stents, polyurethane covered stentgrafts, porous stents with subsequent coiling. Ten animals were treated with coils alone, 10 with clips. After 6 months, angiography, histology, and scanning electron microscopy was performed. Results Porous stents did not obliterate the aneurysm, whereas stentgrafts did; in-stent stenosis of up to 60% was present because of neointimal multilayer proliferation. After coiling, the aneurysm dome was occluded with fibrinous and collagenous material, whereas the aneurysm neck was not covered by an endothelial lining. Coil loops lay bare within the vessel, with fresh thrombus material on their surface. After clipping, a thin layer of endothelial lining bridging the two attached vessel walls was present, thereby completely obliterating the aneurysm and reconstructing the vessel wall. Conclusion This study demonstrates complete and stable aneurysm obliteration with vessel wall reconstruction after clipping, a sufficient obliteration of the aneurysm dome using endovascular techniques, but a failed healing response of the aneurysm neck that might correlate to its associated higher risk of rebleed. Whether or not this is counterbalanced by the better immediate outcome after endovascular treatment remains a matter of debate.
- Published
- 2006
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