1. Curve evolution during bracing in children with scoliosis secondary to early-onset neurofibromatosis type 1: indicators of rapid curve progression
- Author
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Ben-Long Shi, Yang Li, Ze-Zhang Zhu, Sai-Hu Mao, Zhen Liu, Xu Sun, Yong Qiu, and Ning-Ning Wang
- Subjects
medicine.medical_specialty ,Neurofibromatosis 1 ,Scoliosis ,Early-onset scoliosis ,Internal medicine ,Humans ,Medicine ,Curve progression ,Neurofibromatosis ,Child ,Retrospective Studies ,Early onset ,Modulation ,Braces ,Curve evolution ,Cobb angle ,business.industry ,Incidence (epidemiology) ,Retrospective cohort study ,Original Articles ,Bracing treatment ,General Medicine ,medicine.disease ,Treatment Outcome ,Rapid curve progression ,Child, Preschool ,Disease Progression ,Cardiology ,business ,Neurofibromatosis type 1 - Abstract
Background:. Scoliosis secondary to neurofibromatosis type 1 (NF1) in children aged 10°/year) were identified. The age at modulation and the AV before and after modulation were obtained. Patients with (n = 18) and without rapid curve progression (n = 10) were statistically compared. Results:. Twenty-eight patients with a mean age of 6.5 ± 1.9 years at the initial visit were reviewed. The mean Cobb angle of the main curve was 41.7° ± 2.4° at the initial visit and increased to 67.1° ± 8.6° during a mean follow-up of 44.1 ± 8.5 months. The overall AV was 6.6° ± 2.4°/year for all patients. At the last follow-up, all patients presented curve progression of >5°, and 20 (71%) patients had progressed by >20°. Rapid curve progression was observed in 18 (64%) patients and was associated with younger age at the initial visit and a higher incidence of modulation change during follow-up (t = 2.868, P = 0.008 and 10°/year is associated with younger age at the initial visit, and modulation change indicated the occurrence of the rapid curve progression phase.
- Published
- 2021
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