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International audience; The recycling activity of cytidine deaminase (CDA) within the pyrimidine salvage pathway is essential to DNA and RNA synthesis. As such, CDA deficiency can lead to replicative stress, notably in Bloom syndrome. Alternatively, CDA also can deaminate cytidine and deoxycytidine analog-based therapies, such as gemcitabine. Thus, CDA overexpression is often associated with lower systemic, chemotherapy-related, adverse effects but also with resistance to treatment. Considering the increasing interest of CDA in cancer chemoresistance, the aims of this review are to describe CDA structure, regulation of expression, and activity, and to report the therapeutic strategies based on CDA expression that recently emerged for tumor treatment.

This article offers an analysis of the impact of professional social-media engagement upon authors. Authors primarily use Facebook, Twitter and there is growing use of Pinterest. Authors use social-media platforms primarily for marketing, publicity and making contact with readers. They tend to adopt a multi-layered approach to self-presentation and the lines between their ‘public’ and ‘private’ identities are blurred. The research reveals a limited author-reader community, but a much stronger online author–author community, founded upon practical support and encouragement. There are implications for the publishing industry as authors believe their publishers lack social-media expertise. The commercial benefits of maintaining a social-media presence are unclear for many authors.

Based upon empirical research, and using a range of methods, this paper examines the behaviour and experiences of consumers in online bookselling settings and offers comparison between online and offline (traditional) bookselling. The research finds that while the convenience of online bookshops is important, the key factors enticing consumers online are a combination of breadth of range, ease of access to obscure titles, as well as ‘personalised’ recommendations and customer reviews. The research is of value to the book trade, highlighting consumer responses to widely adopted online marketing approaches. The research also contributes to scholarly knowledge in the fields of consumer behaviour, e-marketing and e-commerce in online bookselling, as well as providing findings which can be tested in other online settings, informing future theoretical research.

Purpose – This research theoretically conceptualises the notion of “third place” within the setting of chain bookshops. The widespread adoption of coffee franchises and comfortable seating has developed the bookshop as a leisurely setting. Underpinning the discussion in current retail marketing theory, the research aims to explore how the understanding of “third place” has changed with the passage of time and to examine whether chain bookshops can be called third places. Design/methodology/approach – The methodological approach is largely qualitative, drawing upon interviews with bookshop managers with regard to their strategic aims, and using focus groups to discuss consumers' bookshop experiences. The research also draws upon quantitative data, i.e. face-to-face questionnaires and online surveys. Findings – The research concludes that while consumer experience of chain bookshops is positive, they cannot be called a “third place” due to the lack of conversation therein. Nevertheless, an important caveat exists – the presence of an integral coffee shop encourages socialising among bookshop customers. Research limitations/implications – The project's scope is limited to chain bookshops in the UK. Future work might look at third place or restorative provision in other retail settings or over a wider geographic spread. Practical implications – The research has important implications and recommendations for managers of retail sites regarding the potential restorative qualities of bookshops, coffee shops and other retail environments. Originality/value – This empirical research enhances scholarly understanding of the bookshop as a restorative space, highlighting an important advantage which traditional retailers have over internet retailers.

PurposeThe purpose of this paper is to identify current marketing initiatives undertaken by UK chain booksellers and analyses them in the context of established retailing and marketing theory. Thus, established scholarly theory is being examined in a novel research setting.Design/methodology/approachThe paper includes evidence and findings from semi‐structured, in‐depth interviews with various book trade experts working at different levels within the trade.FindingsFocusing on the strategies behind the chains' marketing techniques, the paper concentrates in particular upon the new emphasis by UK chains upon serving a wider clientele and their efforts to establish individual identities and be “community responsive”. This has resulted in a re‐emphasis both upon customer service and on the relationship between bookseller and customer. New developments in the facilities to be found in chain bookshops, such as coffee shops and the proliferation of sofas and browsing areas are analysed as to their contribution to bookshop “atmosphere”.Originality/valueThis research is both timely, responding to calls from the trade for research and original, given the dearth of research on the book trade. The findings are examined within the context of academic theory in related fields, such as retailing, marketing and consumer behaviour. As such, findings from this highly original research are relevant both for the trade and for the wider academic community regarding their application and consideration in other scholarly settings.

In this viewpoint article we seek to make the farming community aware of the increasing presence of organised criminals and crime within the farming community. In the past decade there has been a discernible rise in the level of organized criminality in rural areas especially in relation to farm crime across Britain and Europe. This has been reported in the media in many European States and is exacerbated by the financial crisis and by a lack of cooperation between member states and agencies.