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The worldwide pandemic situation of COVID-19 generates a situation in which healthcare resources such as diagnostic kits, drugs and basic healthcare infrastructure were on shortage throughout the period, along with negative impact on socio-economic system. Standardized public healthcare models were missing in pandemic situation, covering from hospitalized patient care to local resident’s healthcare managements in terms of monitoring, assess to diagnosis and medicines. This exploratory and intervention-based study with the objective of proposing COVID-19 Care Management Model representing comprehensive care of society including patients (COVID-19 and other diseases) and healthy subjects under integrated framework of healthier management model. Shifting policy towards technology-oriented models with well-aligned infrastructure can achieve better outcomes in COVID-19 prevention and care. The planned development of technical healthcare models for prognosis and improved treatment outcomes that take into account not only genomics, proteomics, nanotechnology, materials science perspectives but also the possible contribution of advanced digital technologies is best strategies for early diagnosis and infections control. In view of current pandemic, a Healthier Healthcare Management Model is proposed here as a source of standardized care having technology support, medical consultation, along with public health model of sanitization, distancing and contact less behaviours practices. Effective healthcare managements have been the main driver of healthier society where, positive action at identified research, technology and management segment more specifically public health, patient health, technology selection and political influence has great potential to enhanced the global response to COVID-19. The implementation of such practices will deliver effective diagnosis and control mechanism and make healthier society.

Biofilm formation is an alliance of microorganisms in which microbial cells constitute an alternative lifestyle and embrace a multicellular behavior that facilitates and/or prolongs survival in adverse environmental niches. In nature, biofilms are present everywhere, and they can be found in places like waste water channels, labs, bathrooms, industrial places, and hospital settings and frequently occur on hard surfaces that are immersed in or exposed to an aqueous solution. It can also be formed as buoyant on surface of liquid; biofilm formation comprises a substitute lifestyle in which microorganisms espouse a multicellular behavior that smooth the way and/or promote prolong survival in diverse environmental niches. Cells in a bacterial biofilm communicate via quorum sensing which is a multistep process that starts with the attachment of cells to a surface and then formation of microcolony that further leads to the formation of three-dimensional structure and finally ending with maturation followed by dispersion or detachment. According to National Institutes of Health (NIH), about 65% of all microbial infections and 80% of all chronic infections are associated with biofilms. Bacterial biofilm is less attainable to antibiotics and human immune system and thus gives rise to ultimatum to public health because of its participation in variety of infectious diseases. A greater understanding of steps leading to biofilm formation on surfaces and within eukaryotic cells, pointing several medically important pathogens, for the development of novel, effective control strategies aimed at biofilm prevention and/or elimination.

Context: Diaphyseal fractures of the radius and ulna are common in the pediatric population. The standard management for pediatric forearm fractures remains conservative management with closed reduction and immobilization with above-elbow plaster cast. Although the fracture unites readily, malunion is very common. Stiffness of joints and compartment syndrome are other complications of conservative management with plaster cast. The introduction of titanium elastic nailing system (TENS) has changed the treatment scenario of fracture of both-bone forearm. Aims: The aim of this study is to evaluate the functional and cosmetic outcome of the management of fracture both-bone forearm by closed reduction and internal fixation with titanium elastic nail system. Subjects and Methods: A total of 40 patients aged 5–15 years with fracture of both radius and ulna were managed by internal fixation with titanium elastic nail. Closed reduction under image intensifier control was achieved in most of the patients. Prospective follow-up was done for 6 months. Results: Results were analyzed in reference to union, symptoms, and range of motion of adjacent joints using Price et al. criteria for outcome evaluation. In our study, 87.5% of patients showed excellent, 10% showed good, and 2.5% showed fair outcome. Conclusion: Better functional and cosmetic outcome with minimal complications is achieved with internal fixation with titanium elastic nail system. TENS may be considered as an alternative to conservative treatment.

COVID-19 is considered as a major public health problem caused by the SARS CoV-2. This Viral infection is known to induce worldwide pandemic in short period of time. Emerging evidence suggested that the transmission control and drug therapy may influence the preventive measures extensively as the host surrounding environment and pathogenic mechanism may contribute to the pandemic condition earlier in COVID-19 disease. Although, several animals identified as reservoir to date, however human-to-human transmission is well documented. Human beings are sustaining the virus in the communities and act as an amplifier of the virus. Human activities i.e., living with the patient, touching patient waste etc. in the surrounding of active patients or asymptomatic persons cause significant risk factors for transmission. On the other hand, drug target and mechanism to destroy the virus or virus inhibition depends on diversified approaches of drugs and different target for virus life cycle. This article describes the sustainable chemical preventive models understanding, requirements, technology adaptation and the implementation strategies in these pandemic-like situations. As the outbreak progresses, healthcare models focused on transmission control through disinfections and sanitization based on risk calculations. Identification of the most suitable target of drugs and regional control model of transmission are of high priority. In the early stages of an outbreak, availability of epidemiological information is important to encourage preventive measures efforts by public health authorities and provide robust evidence to guide interventions. Here, we have discussed the level of adaptations in technology that research professionals display toward their public health preventive models. We should compile a representative data set of adaptations that humans can consider for transmission control and adopt for viruses and their hosts. Overall, there are many aspects of the chemical science and technology in virus preventive measures. Herein, the most recent advances in this context are discussed, and the possible reasons behind the sustainable preventive model are presented. This kind of sustainable preventive model having adaptation and implementation with green chemistry system will reduce the shedding of the virus into the community by eco-friendly methods, and thus the risk of transmission and infection progression can be mitigated., Graphical abstract Image 1

A new compact Ultra-Wideband (UWB) antenna is designed for wearable applications using jeans fabric as the substrate. The proposed antenna has an impedance bandwidth from 3.1 to 11.1 GHz. The antenna footprint is of size 18mm x 26 mm, and the thickness of the substrate is 0.8mm. It is based on a simple patch antenna configuration where the radiator consists of a simple rectangular structure and an ellipse added on top. Circular and elliptical notches are removed from the radiator, and rectangular notches are removed from the feed line for bandwidth enhancement. A partial ground plane of size 18mm x 9mm with a square notch is present on the other side of the antenna. Two such antennas are placed side by side as unit cells, one horizontal and the other vertical, to obtain a 2-port diversity set. The unit cells are placed at a distance such that minimal mutual coupling is present between the cells, and the size is also not compromised. The final diversity set so obtained is of size 44mm x 26 mm. The simulation results for reflection coefficients, SAR, and radiation pattern for both unit cell and diversity port are presented. Diversity parameters like ECC and diversity gain are also simulated for diversity antenna. The results obtained by testing the fabricated prototype are found to be matching reasonably with the simulated results. The antenna is also subjected to bending analysis.

In our country many college and school run by government agencies. There are two categories of employment, one is regular and the other one is contractual. The idea of this paper is conceived looking at violation of human rights in these places. Regular employees enjoy all the facilities such as library, job security air condition chambers in contrast contractual employees deprived from all these facilities. Our intention to find the parameter for why the above said happened by the use of rough set theory ..

This paper considers a decentralized switched control problem where exact conditions for controller synthesis are obtained in the form of semidefinite programming (SDP). The formulation involves a discrete-time switched linear plant that has a nested structure, and whose system matrices switch between a finite number of values according to finite-state automation. The goal of this paper is to synthesize a commensurately nested switched controller to achieve a desired level of $\ell_{2}$ -induced norm performance. The nested structures of both plant and controller are characterized by block lower-triangular system matrices. For this setup, exact conditions are provided for the existence of a finite path-dependent synthesis. These include conditions for the completion of scaling matrices obtained through an extended matrix completion lemma. When individual controller dimensions are chosen at least as large as the plant, these conditions reduce to a set of linear matrix inequalities. The completion lemma also provides an algorithm to complete closed-loop scaling matrices, leading to inequalities for controller synthesis that are solvable either algebraically or numerically through SDP.

Background Visceral leishmaniasis (VL) is a multifactorial disease, where the host genetics play a significant role in determining the disease outcome. The immunological role of anti-inflammatory cytokine, Interleukin 10 (IL10), has been well-documented in parasite infections and considered as a key regulatory cytokine for VL. Although VL patients in India display high level of IL10 in blood serum, no genetic study has been conducted to assess the VL susceptibility / resistance. Therefore, the aim of this study is to investigate the role of IL10 variations in Indian VL; and to estimate the distribution of disease associated allele in diverse Indian populations. Methodology All the exons and exon-intron boundaries of IL10 were sequenced in 184 VL patients along with 172 ethnically matched controls from VL endemic region of India. Result and Discussion Our analysis revealed four variations; rs1518111 (2195 A>G, intron), rs1554286 (2607 C>T, intron), rs3024496 (4976 T>C, 3’ UTR) and rs3024498 (5311 A>G, 3’ UTR). Of these, a variant g.5311A is significantly associated with VL (χ2=18.87; p =0.00001). In silico approaches have shown that a putative micro RNA binding site (miR-4321) is lost in rs3024498 mRNA. Further, analysis of the above four variations in 1138 individuals from 34 ethnic populations, representing different social and linguistic groups who are inhabited in different geographical regions of India, showed variable frequency. Interestingly, we have found, majority of the tribal populations have low frequency of VL (‘A’ of rs3024498); and high frequency of leprosy (‘T’ of rs1554286), and Behcet’s (‘A’ of rs1518111) associated alleles, whereas these were vice versa in castes. Our findings suggest that majority of tribal populations of India carry the protected / less severe allele against VL, while risk / more severe allele for leprosy and Behcet’s disease. This study has potential implications in counseling and management of VL and other infectious diseases.

The definitive version is available at www3.interscience.wiley.com, In this phase III trial for diagnostics for visceral leishmaniasis (VL) in India, we compared parasitological diagnosis with several serological tests: direct agglutination test (freeze dried; DAT-FD), rK-39 strip test, rK-26 strip test and a latex agglutination test for antigen detection in urine (KAtex) in 452 subjects from the endemic regions of Bihar, India. The subjects were segregated into four categories: 230 confirmed patients, 52 probable cases, 70 non-cases and 100 healthy endemic controls. The first two groups were used for estimating sensitivity, the latter two for specificity. Sensitivity of DAT-FD was 98.9%, rK-39: 98.9%, KAtex: 67.0% and rK-26: 21.3%. Sensitivity of DAT-FD on blood taken on filter paper (DAT-FDF) was 99.3%, which was comparable with that using serum. Specificity of serological tests was comparable and high (DAT-FD and DAT-FDF: 94%, rK-39 strip test: 97%, KAtex: 99% and rK-26 strip test: 100%). The classical 'gold standard' parasitological demonstration in splenic smear performed poorly as it missed 18.4% of cases that benefited from VL treatment. Reproducibility of the serological tests between field and central laboratories was excellent (kappa = 1.0, 0.99, 0.96 and 0.94 respectively for microscopy, DAT-FD, rK-39 strip test and rK-26 strip test). A high degree of agreement was observed between DAT-FD and rK-39 strip test (kappa = 0.986). Although DAT-FD and rK-39 strip test were highly sensitive with excellent specificity, the ease of use of the latter makes it most suitable for the diagnosis of VL in the field conditions.