1. Moderate-intensity interval training (MIT) can protect rats against Methamphetamine –induced injuries
- Author
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Alireza Keyhani, Mahla sadat Nabavi Zadeh, Roya Askari, Majid Asadi-Shekaari, Ahad Shafiei Bafti, and Amir Hossein Haghighi
- Subjects
business.industry ,Anesthesia ,Medicine ,Methamphetamine ,business ,Interval training ,medicine.drug ,Intensity (physics) - Abstract
Methamphetamine (METH) can cause neurotoxicity and increase the risk of neurodegenerative disorders such as Alzheimer disease and Parkinson disease. This study aimed to investigate the effect of moderate-intensity interval training (MIT) on gene expression and antioxidant status of the hippocampus of METH-dependent rats. Twenty-eight male Wistar rats were randomly divided into four equal groups (n=7): saline, METH, MIT, and METH+MIT. METH was injected intraperitoneally at 5 mg/kg for 21 days. The MIT (intermittent running) was performed on the treadmill 5 days a week for 8 weeks. Morris Water Maze test was performed to measure learning and memory. Then, the hippocampal tissue was extracted to evaluate changes in gene expression and biochemical enzymes. The data were analyzed using one-way and two-way ANOVA methods at P
- Published
- 2021