854 results on '"Acrodermatitis"'
Search Results
2. Acrodermatitis enteropathica with ocular manifestations
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Aishwarya Rathod, Sahil Agrawal, Sujeeth Modaboyina, and Deepsekhar Das
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medicine.medical_specialty ,genetic structures ,business.industry ,Incidence (epidemiology) ,Acrodermatitis enteropathica ,Acrodermatitis ,General Medicine ,medicine.disease ,Eye ,Dermatology ,eye diseases ,Zinc ,Face ,Failure to thrive ,Medicine ,Humans ,medicine.symptom ,Metabolic disease ,business - Abstract
Acrodermatitis enteropathica is a rare autosomal recessive metabolic disease with occasional ocular manifestations. It was first described by Brandt in 1936 and named so by Danbolt.[1][1] It occurs worldwide with an estimated incidence of 1 per 500 000 children with no apparent predilection for race
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- 2023
3. Transient symptomatic zinc deficiency in an exclusively breastfed infant
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Ermelindo Tavares, Mafalda Santos, Mafalda Crisóstomo, and Florbela Cunha
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Physiology ,Case Report ,Intertriginous ,Breast milk ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Full Term ,Milk, Human ,business.industry ,Acrodermatitis ,Malnutrition ,Gestational age ,Infant ,General Medicine ,medicine.disease ,Zinc ,Breast Feeding ,030220 oncology & carcinogenesis ,Failure to thrive ,Zinc deficiency ,Female ,Flucloxacillin ,medicine.symptom ,business ,medicine.drug - Abstract
A 3-month-old, full term female infant, adequate for gestational age, and exclusively breastfed, was admitted with a 10 day history of generalised scaling erythematous dermatitis, affecting the face (perinasal, nasolabial folds and periauricular), acral and intertriginous areas, with irritability and failure to thrive. Her mother had been treated with isoniazid since the third trimester because of family contact with tuberculosis. Based on a diagnosis of suspected impetiginised eczema, the infant was treated with flucloxacillin and prednisolone, and maternal isoniazid was suspended, with no improvement. Investigations found low serum zinc levels in the infant (33 μg/dL; normal range (NR) >60 μg/dL), normal plasma zinc levels in the mother (111.3 μg/dL; NR 68–120 μg/dL) and lower than the normal range of zinc levels in breast milk (270μg/L; NR 1000–2500 μg/L), suggesting acrodermatitis caused by zinc deficiency. Oral zinc supplementation (3 mg/kg/day) was started with a marked improvement in skin lesions, as well as good weight gain. At the age of 6 months, after food diversification, supplementation was suspended, without any recurrence of symptoms.
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- 2023
4. Generalized pustular psoriasis (von Zumbusch)
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Ricardo Romiti, André Luís da Silva Hirayama, Renata Ferreira Magalhães, and Marcelo Arnone
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Psoriasis/epidemiology ,Sterile pustules ,medicine.medical_specialty ,Skin Diseases, Vesiculobullous ,business.industry ,Acrodermatitis ,Review ,Dermatology ,Disease ,Exanthema ,medicine.disease ,Psoriasis/therapy ,Psoriasis/genetics ,Psoriasis ,Acute Disease ,Chronic Disease ,medicine ,Generalized pustular psoriasis ,Humans ,Psoriasis/physiopathology ,business - Abstract
Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt diagnosis and intervention. The duration of each flare-up and intervals between the pustular episodes is extremely variable. Recently, genetic abnormalities have been identified mainly in the familial and early variants of this disease. The therapeutic arsenal is limited; however, new drugs being evaluated aim to control both pustular flare-ups and disease recurrences.
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- 2022
5. Pustular psoriasis as an autoinflammatory keratinization disease (AiKD): Genetic predisposing factors and promising therapeutic targets
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Masashi Akiyama
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MPO ,Dermatology ,Disease ,Granulocyte ,Biochemistry ,Pathogenesis ,medicine ,Animals ,Humans ,Psoriasis ,Genetic Predisposition to Disease ,Molecular Targeted Therapy ,CARD14 ,Molecular Biology ,AP1S3 ,Biological Products ,Innate immune system ,business.industry ,Acrodermatitis ,Monocyte ,Hereditary Autoinflammatory Diseases ,SERPINA3 ,Keratosis ,medicine.disease ,Cytapheresis ,medicine.anatomical_structure ,IL-36 ,Immunology ,Generalized pustular psoriasis ,Tumor necrosis factor alpha ,IL36RN ,business - Abstract
Pustular psoriasis is a chronic inflammatory skin disease characterized by erythematous plaques with sterile pustules. It includes the distinct clinical entities generalized pustular psoriasis (GPP), acrodermatitis continua of Hallopeau (ACH) and palmoplantar pustular psoriasis (PPPP). Recently clarified pathomechanisms of pustular psoriasis indicate that hyperactivation of the skin innate immunity, including of the IL-1/IL-36 axis, plays an important role in the pathogenesis of pustular psoriasis. Autoinflammatory keratinization disease (AiKD) is the umbrella clinical entity for inflammatory keratinization disorders with genetic autoinflammatory pathomechanisms, and pustular psoriasis is a representative AiKD. To date, mutations/variants in five genes—IL36RN, CARD14, AP1S3, MPO and SERPINA3—have been reported to be genetic causative or predisposing factors for pustular psoriasis. The pathogenic mechanisms induced by the mutations/variants in these genes are all closely related to the excessive activation of skin innate immunity and autoinflammation. A number of biologics (e.g., tumor necrosis factor inhibitors, IL-17/IL-17 receptor inhibitors and IL-23 inhibitors) and granulocyte and monocyte adsorption apheresis are used to treat pustular psoriasis. Recently, based on novel information on the pathomechanisms of pustular psoriasis, which are mainly associated with autoinflammation, inhibitors of several pathogenic pathways, including of the IL-1, IL-36, IL-8 and granulocyte colony-stimulating factor signaling pathways, have been studied as emerging treatments.
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- 2022
6. Autoinflammatory Keratinization Diseases
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A. Peña-Rosado, Jorge Romaní, N. Riera-Martí, and V. Expósito-Serrano
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medicine.medical_specialty ,Histology ,integumentary system ,business.industry ,Acrodermatitis ,Dermatology ,Disease ,medicine.disease_cause ,medicine.disease ,Hidradenitis ,Pathology and Forensic Medicine ,Autoimmunity ,Psoriasis ,medicine ,Medical genetics ,Hidradenitis suppurativa ,Pityriasis rubra pilaris ,business - Abstract
Autoinflammatory keratinization disease (AiKD) is a novel clinical concept encompassing diseases with a genetic background and mixed pathogenic mechanisms of autoinflammation and autoimmunity, leading to an aberrant keratinization of the skin. Recent advances in medical genetics have revealed genetic causes and/or predisposing factors for a number of AiKD’s, such as mutations in IL36RN related with pustular psoriasis, acrodermatitis continua and hidradenitis suppurativa, in CARD14 in pityriasis rubra pilaris type V and some forms of pustular psoriasis, and in NLRP1 related with familial keratosis lichenoides chronica (KLC). It is suspected that AiKD pathophysiology would also be involved in non-monogenic disorders. The bidirectional relationship between inflammation and keratinization should be understood in order to outline optimal management, and new drug development should take both targets into account. We assume that new inflammatory keratinization diseases may be recognized as AiKDs in the coming years.
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- 2021
7. Trastornos autoinflamatorios de la queratinización
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A. Peña-Rosado, V. Expósito-Serrano, N. Riera-Martí, and Jorge Romaní
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medicine.medical_specialty ,Hidradenitis ,Dermatology ,Disease ,medicine.disease_cause ,Autoimmunity ,Psoriasis ,Keratosis lichenoides ,medicine ,Keratinization ,Hidradenitis suppurativa ,Internal medicine ,integumentary system ,business.industry ,Autoinflammatory ,Acrodermatitis ,General Medicine ,medicine.disease ,RC31-1245 ,RL1-803 ,Medical genetics ,Pityriasis rubra pilaris ,Pityriasis rubra ,business - Abstract
Resumen: La enfermedad autoinflamatoria de la queratización (AiKD, por sus siglas en inglés) es un concepto clínico novedoso que engloba a las enfermedades que presentan antecedentes genéticos, así como mecanismos patogénicos mixtos de autoinflamación y autoinmunidad, lo que en su conjunto se traducirá en una queratinización aberrante de la piel. Los recientes avances han revelado causas genéticas y/o factores predisponentes para una serie de AiKD, dentro de los que se pueden enumerar la presencia de las mutaciones en el IL36RN, en relación con la psoriasis pustulosa, la acrodermatitis continua y la hidradenitis supurativa; en el CARD14, en relación con la pitiriasis rubra pilaris tipo V y algunas formas de psoriasis pustulosa, y en el NLRP1 en relación con la queratosis liquenoide crónica familiar (KLC, por sus siglas en inglés). Se sospecha que la fisiopatología de la AiKD también estaría presente en algunos trastornos no monogénicos. Se debe de comprender que existe una relación bidireccional entre la inflamación y la queratinización para poder determinar un tratamiento óptimo; así mismo para poder desarrollar nuevos fármacos ambos factores deben de tenerse en cuenta. Probablemente en los próximos años nuevas enfermedades inflamatorias de la queratinización serán incluidas dentro del grupo de las AiKD. Abstract: Autoinflammatory keratinization disease (AiKD) is a novel clinical concept encompassing diseases with a genetic background and mixed pathogenic mechanisms of autoinflammation and autoimmunity, leading to an aberrant keratinization of the skin. Recent advances in medical genetics have revealed genetic causes and/or predisposing factors for a number of AiKD's, such as mutations in IL36RN related with pustular psoriasis, acrodermatitis continua and hidradenitis suppurativa, in CARD14 in pityriasis rubra pilaris type V and some forms of pustular psoriasis, and in NLRP1 related with familial keratosis lichenoides chronica (KLC). It is suspected that AiKD pathophysiology would also be involved in non-monogenic disorders. The bidirectional relationship between inflammation and keratinization should be understood in order to outline optimal management, and new drug development should take both targets into account. We assume that new inflammatory keratinization diseases may be recognized as AiKDs in the coming years.
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- 2021
8. Successful therapy of acrodermatitis continua of Hallopeau with IL‐23 blockers –two new cases
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Dagmar Wilsmann-Theis, Christian Kromer, Rotraut Mössner, Johannes Mohr, and Norman Langer
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Acrodermatitis ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Dermatology ,medicine.disease ,Virology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Interleukin 23 ,business - Published
- 2021
9. Certolizumab Pegol: A New Therapeutic Approach for Acrodermatitis Continua of Hallopeau
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Federico Diotallevi, Giulio Rizzetto, Giulia Radi, E. Molinelli, and A. M. Offidani
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Therapeutic approach ,medicine.medical_specialty ,Novel Insights from Clinical Practice ,business.industry ,Acrodermatitis ,medicine ,Dermatology ,Certolizumab pegol ,business ,medicine.disease ,medicine.drug - Abstract
Introduction: Acrodermatitis continua of Hallopeau (ACH) is a rare, chronic, and recurrent form of pustular psoriasis (PP) localized to one or more digits. Due to the rarity of ACH, no clear treatment guidelines are currently available, making the therapeutic approach more complex. Case Presentation: We report the first case of a young woman with ACH who was successfully treated with certolizumab pegol (CZP). Discussion/Conclusion: PP and ACH are difficult to treat, and biologics may be an option more manageable than cyclosporine. CZP is the safest biologic therapy during pregnancy, so there is low risk in prescribing it in women with childbearing potential. However, continuing biological therapy during pregnancy always involves an assessment of the clinical benefits, which must outweigh the risks.
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- 2021
10. Treatment and molecular profiling of acrodermatitis continua of Hallopeau during pregnancy using targeted therapy
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Gulab Sher, Khairunnisa Hussain, Joerg Buddenkotte, Roopesh Krishnankutty, Martin Steinhoff, and Sara Al-Khawaga
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Pregnancy ,certolizumab ,TNF, tumor necrosis factor ,business.industry ,Acrodermatitis ,medicine.medical_treatment ,Interleukin ,Case Report ,Dermatology ,psoriasis ,medicine.disease ,Certolizumab ,Targeted therapy ,IL, interleukin ,guselkumab ,Guselkumab ,proteomics ,Psoriasis ,RL1-803 ,medicine ,Cancer research ,Tumor necrosis factor alpha ,cytokine profiling ,business ,ACH, acrodermatitis continua of Hallopeau - Published
- 2021
11. Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant
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Guillaume Smits, Alfredo Vicinanza, Corinne De Laet, Pascale Perlot, Guillaume Deprez, Déborah Salik, Catheline Vilain, and Giovanna D’Amico
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0301 basic medicine ,breastfeeding ,acrodermatitis enteropathica ,Breastfeeding ,Physiology ,chemistry.chemical_element ,Case Report ,Zinc ,Disease ,Pediatrics ,RJ1-570 ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,zinc deficiency ,Medicine ,Risk factor ,030109 nutrition & dietetics ,business.industry ,Acrodermatitis ,Acrodermatitis enteropathica ,zinc supplementation ,medicine.disease ,premature infant ,chemistry ,Zinc deficiency ,business - Abstract
We present a case of a transient acquired zinc deficiency in a breast-fed, 4-month-old-male prematurely born infant, with acrodermatitis enteropathica-like symptoms such as crusted, eroded, erythemato-squamous eruption in periorificial and acral patterns. The laboratory investigations showed low zinc levels in the infant’s and the mother’s serum and in the mother’s milk; genetic analysis did not show any mutation in the SLC39A4 gene, involved in acrodermatitis enteropathica. Acquired zinc deficiency is often found in premature infants because of their increased requirement, the low serum and milk zinc levels in breastfeeding women being also an important risk factor, as in this case. A prompt zinc supplementation is essential for the good prognosis of the disease.
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- 2021
12. Acrodermatitis Continua of Hallopeau Evolving into Generalized Pustular Psoriasis Following COVID‐19: A Case Report of a Successful Treatment with Infliximab in Combination with Acitretin
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Ewelina Gawron, Justyna Szczęch, Adam Reich, Elżbieta Ostańska, and Dominik Samotij
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,coronavirus ,Case Report ,medicine.disease_cause ,Acitretin ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Psoriasis ,Immunology and Allergy ,Medicine ,biologics ,Pharmacology (medical) ,biologic therapy ,Coronavirus ,SARS-CoV-2 ,business.industry ,Acrodermatitis ,Gastroenterology ,psoriasis ,medicine.disease ,Dermatology ,Infliximab ,pustular psoriasis ,Oncology ,030220 oncology & carcinogenesis ,Generalized pustular psoriasis ,business ,medicine.drug - Abstract
The global pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is emerging. Various cutaneous manifestations have been observed in patients with SARS-CoV-2 infection, yet exacerbations of psoriasis have been reported sporadically. Acrodermatitis continua of Hallopeau (ACH) is an uncommon, sterile pustular dermatosis involving one or more digits. In some rare cases, ACH may evolve into generalized pustular psoriasis (GPP), which is a severe, and potentially life-threatening, form of psoriasis that manifests itself with widespread eruptions of pustules. We describe the first case of a patient in whom ACH abruptly progressed into GPP during COVID-19. A combination of infliximab and acitretin was used allowing swift clinical improvement.
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- 2021
13. Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients
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Vera Maraspin, Lara Lusa, T. Cerar Kišek, Katarina Ogrinc, Eva Ružić-Sabljić, and Franc Strle
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Constitutional symptoms ,Slovenia ,Arthritis ,030204 cardiovascular system & hematology ,Borrelia afzelii ,medicine.disease_cause ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Borrelia burgdorferi Group ,Arthropathy ,Internal Medicine ,medicine ,Humans ,Aged ,Paresis ,Lyme Disease ,business.industry ,Acrodermatitis ,Middle Aged ,medicine.disease ,Dermatology ,030104 developmental biology ,Peripheral neuropathy ,Cohort ,Female ,Atrophy ,medicine.symptom ,business ,Acrodermatitis chronica atrophicans - Abstract
BACKGROUND Information on large groups of patients with acrodermatitis chronica atrophicans (ACA) is limited. METHODS We assessed clinical and microbiological characteristics of patients with ACA diagnosed at a single medical centre and compared findings in periods 1991-2004 vs. 2005-2018. The cohort is representative of Slovenian ACA patients. RESULTS We assessed 693 patients: 461 females and 232 males, with median age of 64 years. Median duration of ACA before diagnosis was 12 months. In all but 2 patients, the skin lesions were located on extremities, more often on the lower (70.0%) than the upper (45.2%), bilaterally in 42.4%. Reddish-blue discoloration, swelling, thinning and wrinkling of skin were present in 95.2%, 28.1%, 46.4% and 20.5% of patients, respectively. Overall, 64.4% of patients reported constitutional symptoms, 23.1% had local symptoms, and 20.8% had symptoms/signs of peripheral neuropathy. Nodules, arthritis, joint deformity, muscle atrophy and paresis were rare (
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- 2021
14. Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives
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Giovanni Genovese, Emilio Berti, Angelo V. Marzano, and Chiara Moltrasio
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medicine.medical_specialty ,Urticaria ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Review Article ,Dermatology ,medicine.disease_cause ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Hyposmia ,medicine ,Humans ,Purpura ,Exanthem ,Livedo Reticularis ,Livedo reticularis ,Coronavirus ,SARS-CoV-2 ,business.industry ,Hypogeusia ,Acrodermatitis ,Patient Acuity ,COVID-19 ,Exanthema ,medicine.disease ,Cutaneous manifestations ,Morbilliform rash ,030220 oncology & carcinogenesis ,medicine.symptom ,business - Abstract
Background: Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, dyspnea and hypogeusia/hyposmia. Among extrapulmonary signs associated with COVID-19, dermatological manifestations have been increasingly reported in the last few months. Summary: The polymorphic nature of COVID-19-associated cutaneous manifestations led our group to propose a classification, which distinguishes the following six main clinical patterns: (i) urticarial rash, (ii) confluent erythematous/maculopapular/morbilliform rash, (iii) papulovesicular exanthem, (iv) chilblain-like acral pattern, (v) livedo reticularis/racemosa-like pattern, (vi) purpuric “vasculitic” pattern. This review summarizes the current knowledge on COVID-19-associated cutaneous manifestations, focusing on clinical features and therapeutic management of each category and attempting to give an overview of the hypothesized pathophysiological mechanisms of these conditions.
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- 2020
15. Pemphigus vegetans of Hallopeau masquerading as acrodermatitis continua suppurativa
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Rashmi Jindal, Payal Chauhan, and Sadhana Raturi
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medicine.medical_specialty ,Infectious Diseases ,business.industry ,Acrodermatitis ,medicine ,Dermatology ,medicine.disease ,business ,Pemphigus vegetans - Published
- 2021
16. Psoriasiform plaques on the dorsa of the feet responding to zinc supplementation
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N. Tyagi, Poonam Elhence, Ravikumar Mudugal, and A. Budania
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medicine.medical_specialty ,Adolescent ,Foot ,business.industry ,Biopsy ,Acrodermatitis ,Psoriasiform plaques ,chemistry.chemical_element ,Dermatology ,Zinc ,Treatment Outcome ,chemistry ,Erythema ,Dietary Supplements ,medicine ,Humans ,Psoriasis ,Female ,business - Published
- 2020
17. Clinical characteristics, genetics, comorbidities and treatment of palmoplantar pustulosis: A retrospective analysis of 66 cases in a single center in Taiwan
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Tsen-Fang Tsai and Chang-Ming Huang
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Adult ,medicine.medical_specialty ,Palmoplantar pustulosis ,Taiwan ,Demographic study ,Dermatology ,Demographic data ,Single Center ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,medicine ,Retrospective analysis ,Humans ,Retrospective Studies ,business.industry ,Interleukins ,Acrodermatitis ,General Medicine ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Mutation ,Generalized pustular psoriasis ,Female ,business - Abstract
We retrospectively analyzed 66 patients with palmoplantar pustulosis (PPP) from January 1994 to September 2019 in our department. Interleukin-36 receptor antagonist gene (IL36RN) intron 3 c.115+6T>C mutation was present in two out of 27 patients (7.4%). Both cases developed generalized pustular psoriasis and/or acrodermatitis continua of Hallopeau later. Topical medications and phototherapy were used in 93.9% and 28.8% of patients, respectively, while 60.6% received systemic agents. The majority of patients (60.6%) responded to treatment, but episodes of flare-up existed. The demographic data of our patients with PPP showed female predominance (59.1%), middle-age onset (44.2 years old) and current smokers (62.1%). Generalized pustular psoriasis initially presenting as palmoplantar lesions may be misdiagnosed as PPP, and the presence of IL36RN mutation may serve to predict or confirm the diagnosis of future generalized pustular psoriasis or acrodermatitis continua of Hallopeau. To our knowledge, this is the largest demographic study of PPP in Taiwan.
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- 2020
18. Dermatological manifestations of Epstein‐Barr virus systemic infection: a case report and literature review
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Giulia Ciccarese, Ilaria Trave, Aurora Parodi, Astrid Herzum, and Francesco Drago
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Adult ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,medicine.medical_specialty ,Adolescent ,Mononucleosis ,Dermatology ,medicine.disease_cause ,Asymptomatic ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Ampicillin ,medicine ,Maculopapular rash ,Humans ,Infectious Mononucleosis ,Child ,Exanthem ,business.industry ,Acrodermatitis ,Exanthema ,Amoxicillin ,medicine.disease ,Epstein–Barr virus ,Pharyngitis ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Epstein-Barr virus (EBV) is a human herpesvirus spread in childhood by contact with saliva. In all populations, the great majority of people are infected by middle age. EBV can cause asymptomatic infection, nonspecific symptoms or, especially in adolescents and young adults, the infectious mononucleosis (IM), characterized by pharyngitis, lymphadenopathy, fatigue, and fever. Two main types of skin rashes, accounted as atypical exanthems, occur in patients with acute IM: a faint erythematous maculopapular eruption of 24-48 hours duration (5-15% of the patients) or a pruritic maculopapular rash in almost all patients receiving ampicillin or amoxicillin. Moreover EBV acute infection has been related to other cutaneous manifestations, such as Gianotti-Crosti syndrome, unilateral laterothoracic exanthem (especially in children), and others. In this study, we reported a case of atypical exanthem with an erythematous-papulovesicular pattern in a 22-year-old female patient with IM and performed a review of the literature of the cutaneous and mucosal eruptions occurring during EBV acute infections.
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- 2020
19. Exanthem und schmerzhaftes Bein bei einer 72-jährigen Patientin
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S. Macagnino
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Gynecology ,medicine.medical_specialty ,business.industry ,Acrodermatitis ,030204 cardiovascular system & hematology ,medicine.disease ,Thrombophlebitis ,03 medical and health sciences ,Venous thrombosis ,0302 clinical medicine ,Internal Medicine ,medicine ,030212 general & internal medicine ,business - Abstract
Berichtet wird der Fall einer 72-jahrigen Patientin mit Exanthem und begleitender Neuropathie am Fusrucken sowie gleichseitigem progredientem Unterschenkelschmerz. Sonographisch wurde eine vom Exanthem ausgehende oberflachliche Thrombose mit Extension in das tiefe Venensystem festgestellt. Auf Grundlage des klinischen Bilds sowie serologischer und elektrophysiologischer Befunde wurde die seltene Diagnose einer Acrodermatitis chronica atrophicans mit peripherer Neuropathie gestellt, die masgeblich die lokale Entwicklung venoser Thrombosen begunstigen konnte.
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- 2020
20. Clinical Case of Rare Variant of Inherited Dermatosis: Acrodermatitis Enteropathica
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Elena Y. Khorosheva, Kseniya P. Kuzmicheva, Elena B. Khramova, Olga A. Rychkova, Natalya E. Gorokhova, and Elena I. Malinina
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medicine.medical_specialty ,hypozincemia ,acrodermatitis enteropathica ,Pediatrics ,RJ1-570 ,Cow milk ,children ,periorificial dermatitis ,Medicine ,erosive-desquamative dermatitis ,clinical case ,business.industry ,Acrodermatitis ,Acrodermatitis enteropathica ,zinc sulfate ,medicine.disease ,Dermatology ,Periorificial dermatitis ,Diarrhea ,Pediatrics, Perinatology and Child Health ,Zinc deficiency ,Clinical case ,erosions ,Differential diagnosis ,medicine.symptom ,business - Abstract
Background . Acrodermatitis enteropathica is the rare form of inherited dermatoses. The disease onset in children is associated with the ablactation and the beginning of cow milk products use, that makes differential diagnosis of acrodermatitis and allergic dermatoses pretty difficult. The caution of specialists to hypozincemia at periorificial dermatitis combined with alopecia and diarrhea in infants will allow to establish correct diagnosis and choose management timely. Clinical Case Description . The clinical case of erosive- desquamative dermatitis combined with alopecia and hypozincemia is presented in this article. Positive dynamics of skin lesion due to administration with zinc sulfate medication is shown. Conclusion . The presence of periorificial dermatitis in the child of any age requires to perform the differential diagnosis for zinc deficiency conditions.
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- 2020
21. Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature
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Yongfeng Chen, Wei Zhong, Yu-Qi Huang, Chao Yang, and Lei Zhu
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Male ,Heterozygote ,Genetic counseling ,Acrodermatitis enteropathica ,Case Report ,Genotype-phenotype ,medicine.disease_cause ,Compound heterozygosity ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Exon ,0302 clinical medicine ,Diseases in Twins ,Humans ,Medicine ,Missense mutation ,030212 general & internal medicine ,Cation Transport Proteins ,Genetics ,Mutation ,Splice site mutation ,business.industry ,Acrodermatitis ,lcsh:RJ1-570 ,Infant ,SLC39A4 gene ,lcsh:Pediatrics ,medicine.disease ,Periorificial dermatitis ,Pedigree ,Zinc ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
BackgroundAcrodermatitis enteropathica (AE) is a rare autosomal recessive hereditary skin disease caused by mutations in the SLC39A4 gene and is characterized by periorificial dermatitis, alopecia and diarrhoea due to insufficient zinc absorption. Only one of the three known sets of twins with AE has genetic information. This case reports the discovery of new mutation sites in rare twin patients and draws some interesting conclusions by analysing the relationship between genetic information and clinical manifestations.Case presentationHere, we report a pair of 16-month-old twin boys with AE exhibiting periorificial and acral erythema, scales and blisters, while subsequent laboratory examination showed normal plasma zinc and alkaline phosphatase levels. Further Sanger sequencing demonstrated that the patients were compound heterozygous for two unreportedSLC39A4mutations: a missense mutation in exon 5 (c.926G > T), which led to a substitution of the 309th amino acid residue cysteine with phenylalanine, a splice site mutation occurring in the consensus donor site of intron 5 (c.976 + 2 T > A). A family study revealed that the boys’ parents were heterozygous carriers of these two mutations.ConclusionWe identified a new compound heterozygous mutation in Chinese twins with AE, which consisted of two previous unreported variants in exon 5 and intron 5 of SLC39A4. We propose an up-to-date review that different mutations in SLC39A4 may exhibit different AE manifestations. In conjunction with future research, our work may shed light on genotype-phenotype correlations in AE patients and provide knowledge for genetic counselling and treatment for AE patients.
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- 2020
22. Gianotti-Crosti syndrome-like reaction to molluscum contagiosum-Clinical characteristics and response to treatment
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Lisa Weibel, Christina Bürgler, Isabelle Luchsinger, Agnes Schwieger-Briel, Martin Theiler, Nicole Knöpfel, University of Zurich, and Theiler, Martin
- Subjects
Male ,Papular eruption ,medicine.medical_specialty ,Molluscum Contagiosum ,Corticosteroid treatment ,610 Medicine & health ,Dermatology ,2708 Dermatology ,Medicine ,Humans ,10220 Clinic for Surgery ,Child ,Retrospective Studies ,Skin ,Molluscum contagiosum ,business.industry ,Acrodermatitis ,Gianotti–Crosti syndrome ,Exanthema ,medicine.disease ,Rash ,Response to treatment ,Trunk ,Anxiety ,medicine.symptom ,business - Abstract
BACKGROUND AND OBJECTIVES Molluscum contagiosum (MC) is a common viral infection. Hypersensitivity reactions reminiscent of Gianotti-Crosti syndrome, termed Gianotti-Crosti syndrome-like reaction (GCLR), have been reported in a subset of patients. We report a series of patients with GCLR, better delineating its clinical presentation and course. PATIENTS AND METHODS Retrospective chart review of all children presenting with GCLR at our Pediatric Skin Center between 2015 and 2020. RESULTS 26 children (14 boys) with a median age of 6.5 (3-11.3) years were included. GCLR involved the extensor surfaces of the extremities in all patients. More widespread eruptions also affected the trunk and face in 7 (27��%) and 6 (23��%) children respectively. Involvement of the skin overlying the Achilles tendons was a new finding in 4 (15��%) children. Itch was the predominant symptom in 20 (77��%) patients. The rash responded to topical and/or systemic corticosteroids and resolved within four weeks. GCLR was followed by clearance of MC in all patients within 9 (4-24) weeks. CONCLUSIONS GCLR is a characteristic acute, wide-spread, pruritic papular eruption, which often leads to emergency consultations and anxiety in affected patients. GCLR responds well to corticosteroid treatment, has a benign course, and heralds the healing of MC.
- Published
- 2021
23. Pustular Psoriasis: From Pathophysiology to Treatment
- Author
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Giovanni Genovese, Nicoletta Cassano, Carlo Alberto Maronese, Chiara Moltrasio, Angelo V. Marzano, and Gino A. Vena
- Subjects
palmoplantar pustulosis ,medicine.medical_specialty ,Palmoplantar pustulosis ,clinical features ,QH301-705.5 ,impetigo herpetiformis ,Medicine (miscellaneous) ,Review ,General Biochemistry, Genetics and Molecular Biology ,Pathogenesis ,Psoriasis ,medicine ,Biology (General) ,therapy ,business.industry ,Acrodermatitis ,pathogenesis ,palmoplantar pustular psoriasis ,medicine.disease ,Acquired immune system ,Dermatology ,Pathophysiology ,pustular psoriasis ,Generalized pustular psoriasis ,generalized pustular psoriasis ,business ,Impetigo herpetiformis ,acrodermatitis continua of Hallopeau - Abstract
Pustular psoriasis (PP) is a clinicopathological entity encompassing different variants, i.e., acute generalized PP (GPP), PP of pregnancy (impetigo herpetiformis), annular (and circinate) PP, infantile/juvenile PP, palmoplantar PP/palmoplantar pustulosis, and acrodermatitis continua of Hallopeau (ACH), which have in common an eruption of superficial sterile pustules on an erythematous base. Unlike psoriasis vulgaris, in which a key role is played by the adaptive immune system and interleukin (IL)-17/IL-23 axis, PP seems to be characterized by an intense inflammatory response resulting from innate immunity hyperactivation, with prominent involvement of the IL-36 axis. Some nosological aspects of PP are still controversial and debated. Moreover, owing to the rarity and heterogeneity of PP forms, data on prognosis and therapeutic management are limited. Recent progresses in the identification of genetic mutations and immunological mechanisms have promoted a better understanding of PP pathogenesis and might have important consequences on diagnostic refinement and treatment. In this narrative review, current findings in the pathogenesis, classification, clinical features, and therapeutic management of PP are briefly discussed.
- Published
- 2021
24. Novel nonsense mutation in the SLC39A4 gene in a Japanese boy with mild acrodermatitis enteropathica
- Author
-
Mariko Seishima, Hajime Nakano, Zenichiro Kato, Chisato Tawada, and Naohisa Ichiki
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Acrodermatitis ,Acrodermatitis enteropathica ,Nonsense mutation ,Dermatology ,General Medicine ,medicine.disease ,Zinc ,Japan ,Codon, Nonsense ,medicine ,Humans ,business ,Cation Transport Proteins ,Gene - Published
- 2021
25. Risk of scarring in Gianotti-Crosti Syndrome
- Author
-
Cristian Podoleanu, Simona Stolnicu, and Anca Chiriac
- Subjects
Diagnosis, Differential ,Cicatrix ,medicine.medical_specialty ,business.industry ,Acrodermatitis ,Pediatrics, Perinatology and Child Health ,medicine ,MEDLINE ,Humans ,Gianotti–Crosti syndrome ,medicine.disease ,business ,Dermatology - Published
- 2021
26. A case of recurrent vaccine-triggered Gianotti–Crosti syndrome
- Author
-
Perla Zeinaty, Joy Assaf, Farid Stephan, and Roland Tomb
- Subjects
endocrine system ,medicine.medical_specialty ,recurrence ,Case Report ,acrodermatitis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,health services administration ,polycyclic compounds ,medicine ,030212 general & internal medicine ,child ,business.industry ,Acrodermatitis ,trigger ,Gianotti–Crosti syndrome ,vaccination ,medicine.disease ,Dermatology ,Vaccination ,sense organs ,business ,hormones, hormone substitutes, and hormone antagonists ,Biotechnology ,Papulovesicular eruption - Abstract
Gianotti–Crosti syndrome (GCS) is a self-limited benign dermatosis, clinically characterized by a monomorphic papular or papulovesicular eruption symmetrically distributed on the limbs and face of children. Various viral and vaccine triggers have been associated with GCS. Recurrences are uncommon but have been reported. We report a case of recurrent vaccine-triggered GCS., Lay abstract The aim of this paper is to give pediatricians and dermatologists a more precise idea of recurrent Gianotti–Crosti syndrome that occurs following vaccine administration to eventually prevent unnecessary investigations in future patients or vaccination restrictions.
- Published
- 2021
27. Acute adverse reaction to self-prescribed potassium hydroxide 5% solution in a child with papular acrodermatitis of childhood
- Author
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Ilia Bresesti, Christian Ciolfi, Marco Messina, Valeria Brazzelli, and Eugenio Isoletta
- Subjects
medicine.medical_specialty ,Potassium hydroxide ,business.industry ,Potassium Compounds ,Acrodermatitis ,Dermatology ,medicine.disease ,Child ,Humans ,Hydroxides ,Skin Abnormalities ,chemistry.chemical_compound ,Infectious Diseases ,chemistry ,medicine ,business ,Adverse effect - Published
- 2021
28. Exacerbation of acrodermatitis chronica atrophicans under antiretroviral treatment in an HIV-infected patient
- Author
-
F. Berteau, A. Lauzeral, V. Dubée, S. Michalak, P. Traversat, and R. Mahieu
- Subjects
medicine.medical_specialty ,Lyme Disease ,Exacerbation ,business.industry ,Acrodermatitis ,HIV Infections ,Dermatology ,Skin Diseases, Bacterial ,medicine.disease ,Infectious Diseases ,Hiv infected ,medicine ,Antiretroviral treatment ,Skin Abnormalities ,Humans ,Atrophy ,business ,Acrodermatitis chronica atrophicans - Published
- 2021
29. A pitfall in diagnosing psoriatic arthritis resolved by ultrasound: acrodermatitis continua suppurativa of Hallopeau
- Author
-
Valentin S. Schäfer, Svenja Müller, Galina Balakirski, Sietske Poortinga, Dagmar Wilsmann-Theis, and P. Karakostas
- Subjects
medicine.medical_specialty ,Perfusion Imaging ,Hand Dermatoses ,Diagnosis, Differential ,Psoriatic arthritis ,Finger Phalanges ,Nail Diseases ,Young Adult ,Rheumatology ,Adrenal Cortex Hormones ,Finger Joint ,medicine ,Humans ,Pharmacology (medical) ,business.industry ,Acrodermatitis ,Ultrasound ,Arthritis, Psoriatic ,Ultrasonography, Doppler ,medicine.disease ,Dermatology ,Arthralgia ,Radiography ,Methotrexate ,Treatment Outcome ,Antirheumatic Agents ,Female ,Ultrasonography ,business - Published
- 2021
30. Gianotti-Crosti syndrome-like eruption and molluscum contagiosum
- Author
-
Maddalena Napolitano, Martina Tolone, Stefano Dastoli, Maria Passante, Cataldo Patruno, Luigi Bennardo, and Steven Paul Nisticò
- Subjects
Molluscum contagiosum ,medicine.medical_specialty ,Molluscum Contagiosum ,business.industry ,Acrodermatitis ,Dermatology ,Gianotti–Crosti syndrome ,Exanthema ,medicine.disease ,Tooth Eruption ,Infectious Diseases ,Medicine ,Humans ,business - Published
- 2021
31. Acral edema during the COVID‐19 pandemic
- Author
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Jara Valtueña, Daniel Ruiz-Sánchez, Victor Volo, Pilar Manchado-López, and María Garayar-Cantero
- Subjects
medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Biopsy ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Pain ,Dermatology ,Severity of Illness Index ,Betacoronavirus ,Edema ,Correspondence ,Pandemic ,medicine ,Humans ,Skin pathology ,Pandemics ,Pain Measurement ,Skin ,SARS-CoV-2 ,business.industry ,Acrodermatitis ,COVID-19 ,medicine.disease ,Pneumonia ,medicine.symptom ,Coronavirus Infections ,business - Published
- 2020
32. Alopecia universalis‐like hair loss in acrodermatitis enteropathica
- Author
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D. Veitch, A. Shah, and Karen E. Harman
- Subjects
medicine.medical_specialty ,business.industry ,Acrodermatitis ,Homozygote ,Acrodermatitis enteropathica ,Infant ,Alopecia ,Dermatology ,medicine.disease ,Zinc ,Hair loss ,Alopecia universalis ,Mutation ,medicine ,Humans ,Female ,business ,Cation Transport Proteins - Published
- 2020
33. Association between micronutrient deficiency dermatoses and clinical outcomes in hospitalized patients
- Author
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Sabrina M. Shearer, Benjamin H. Kaffenberger, Rachel L. Marsh, and John Trinidad
- Subjects
Pediatrics ,medicine.medical_specialty ,Micronutrient deficiency ,business.industry ,Hospitalized patients ,Acrodermatitis ,MEDLINE ,Case-control study ,Dermatology ,Hospital mortality ,Length of Stay ,Zinc ,Case-Control Studies ,Zinc deficiency (plant disorder) ,Prevalence ,Humans ,Medicine ,Hospital Mortality ,Micronutrients ,Scurvy ,Deficiency Diseases ,business - Published
- 2020
34. Clinical Spectrum of Inherited Disorders of Metabolism
- Author
-
R Abinesh, Lalitha Janakiraman, and Ramaswamy Ganesh
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Adolescent ,India ,Physiology ,Lysosomal storage disorders ,Newly diagnosed ,Consanguinity ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,Humans ,Prospective Studies ,Mortality ,Child ,Amino Acid Metabolism, Inborn Errors ,Beta oxidation ,business.industry ,Mortality rate ,Acrodermatitis ,Infant, Newborn ,Infant ,nutritional and metabolic diseases ,Metabolism ,Peroxisome ,medicine.disease ,Lysosomal Storage Diseases ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Complication ,business ,Metabolism, Inborn Errors ,030217 neurology & neurosurgery - Abstract
To study the clinical profile and outcome of children with Inborn errors of metabolism. Thirty one newly diagnosed children with Inborn errors of metabolism over a 1 y period were studied for their relevant clinical, biochemical, diagnosis, treatment and follow-up details. Inborn errors of metabolism accounted for 2% of hospital admissions. Sixty five percent were born to parents of consanguineous marriage. Of the 31 children with Inborn errors of metabolism, 16 (51%) had lysosomal storage disorders, 8 (26%) had disorders of amino acid metabolism, 2 (6%) each had disorders of carbohydrate and bile acid metabolism, 1 (3%) each had disorders of fatty acid oxidation, mitochondrial and peroxisome metabolism. Acrodermatitis dysmetabolica, as a complication was observed in one child and the overall mortality rate in this series was 10%. Lysosomal storage disorders constituted the majority of Inborn errors of metabolism in this series and amino acidopathies/organic acidemias were successfully treated with special formulas.
- Published
- 2019
35. Outcomes of various types of therapy in patients with treatment-resistant acrodermatitis continua of Hallopeau
- Author
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LM Smirnova, O. Yu Olisova, E. M. Anpilogova, and E. Yu. Vertieva
- Subjects
medicine.medical_specialty ,business.industry ,Acrodermatitis ,medicine.medical_treatment ,Gastroenterology ,Dystrophy ,Disease ,medicine.disease ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,Rheumatology ,030220 oncology & carcinogenesis ,Psoriasis ,PUVA therapy ,medicine ,Immunology and Allergy ,Pharmacology (medical) ,Methotrexate ,Secukinumab ,Apremilast ,business ,medicine.drug - Abstract
Background: Chronic acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis predominantly affecting the distal phalanges of the fingers and toes. The disease manifests by pustular rash with marked infiltration, fissures, and often results into severe dystrophy of nail plates. ACH is refractory to most of psoriasis standard of care (SOC) therapies. Objective: The objective of this study is to assess the prospects of secukinumab therapy of ACH based on current clinical observation. Methods: We observed a female patient with ACH. Number of SOC treatments were applied in that case including local PUVA therapy, systemic retinoids, methotrexate, and biologic agents. Result: Secukinumab, a IL-17 inhibitor, demonstrated pronounced clinical effect in the case of ACH refractory to other SOC therapies. Conclusion: IL-17 inhibition provided by secukinumab was linked to clinically meaningful improvement in the heavily pretreated ACH. Further exploration and clinical studies may be important to provide more data on secukinumab effects in ACH.
- Published
- 2019
36. Novel nonsense mutation of the SLC39A4 gene in a family with atypical acrodermatitis enteropathica
- Author
-
F. Wu, Bin Yang, X. Shi, Y. Zhang, Ping Lu, Mao-Qiang Man, and C. Yang
- Subjects
Adult ,Administration, Topical ,Treatment outcome ,Nonsense mutation ,Administration, Oral ,Dermatology ,Bioinformatics ,Asian People ,medicine ,Humans ,Cation Transport Proteins ,Gene ,business.industry ,Siblings ,Acrodermatitis ,Acrodermatitis enteropathica ,medicine.disease ,Anti-Bacterial Agents ,Pedigree ,Trace Elements ,Zinc ,Treatment Outcome ,Codon, Nonsense ,Zinc deficiency ,Female ,business - Published
- 2019
37. Zinc and skin: an update
- Author
-
Valerie Glutsch, Henning Hamm, and Matthias Goebeler
- Subjects
Physiology ,chemistry.chemical_element ,Dermatology ,Zinc ,medicine.disease_cause ,Skin Diseases ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Zinc Deficiency Disorder ,0302 clinical medicine ,Malabsorption Syndromes ,medicine ,Humans ,Child ,Wound Healing ,Mutation ,business.industry ,Acrodermatitis ,Acrodermatitis enteropathica ,Infant ,medicine.disease ,Zinc homeostasis ,chemistry ,Child, Preschool ,Zinc deficiency ,Etiology ,Alkaline phosphatase ,Hair Diseases ,business - Abstract
The essential trace element zinc (Zn) plays a key role in the development, differentiation and growth of various human tissues. Zinc homeostasis is primarily regulated by two zinc transporter families (solute-linked carrier families, SLC). Disturbances in zinc metabolism may give rise to disorders that typically manifest themselves on the skin. An autosomal recessive zinc deficiency disorder, acrodermatitis enteropathica is caused by a mutation in the gene coding for the ZIP4 transporter. Due to intestinal malabsorption, affected infants develop clinical signs and symptoms shortly after weaning. Acquired zinc deficiency is a rare but underdiagnosed disorder associated with various etiologies and variable clinical manifestations. Depending on the patient's age, a multitude of causes have to be considered. Given the characteristic periorificial and acral lesions, the clinical diagnosis is usually made by dermatologists. Laboratory confirmation includes measurement of plasma zinc levels and - as a supplementary measure - zinc-dependent enzymes such as alkaline phosphatase. Oral zinc replacement therapy frequently leads to clinical remission within a few days. Depending on the cause, disease management should include cooperation with pediatricians and gastroenterologists in order to guarantee optimal patient care.
- Published
- 2019
38. Acrodermatitis continua of Hallopeau
- Author
-
Dimitris Rigopoulos
- Subjects
medicine.medical_specialty ,business.industry ,Acrodermatitis ,Medicine ,business ,medicine.disease ,Dermatology - Published
- 2021
39. Simultaneous Development of Gianotti-Crosti Syndrome and Erythema Multiforme Following Second Dose of Measles-rubella Vaccine
- Author
-
Masahiro Oka
- Subjects
Target lesion ,Erythema Multiforme ,medicine.medical_specialty ,business.industry ,target lesion ,Acrodermatitis ,Measles Vaccine ,Infant ,General Medicine ,Gianotti–Crosti syndrome ,Dermatology ,medicine.disease ,Measles ,Rubella vaccine ,vaccine ,RL1-803 ,medicine ,Humans ,Erythema multiforme ,business ,erythema multiforme: gianotti-crosti syndrome ,Measles-Mumps-Rubella Vaccine ,medicine.drug - Published
- 2021
40. Gianotti‐crosti syndrome in the setting of recent coronavirus disease‐19 infection
- Author
-
Ritu Swali, Jennifer L. Adams, and Erica B Lee
- Subjects
Gianotti‐Crosti ,Pediatrics ,medicine.medical_specialty ,pediatrics ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Adult population ,Case Report ,Dermatology ,Disease ,medicine.disease_cause ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,COVID‐19 ,Pandemic ,medicine ,Coronavirus ,business.industry ,Acrodermatitis ,Gianotti–Crosti syndrome ,medicine.disease ,virology ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,exanthema ,business - Abstract
Since the onset of the COVID‐19 pandemic, the growing body of literature has largely focused on the adult population. Reported symptoms among children appear to be consistent with those in adults, including fever, respiratory symptoms, and gastrointestinal symptoms, though children may experience an overall milder disease course. Viral exanthems with possible association to COVID‐19 have been reported in pediatric patients. We describe a 10‐month‐old boy with Gianotti‐Crosti syndrome in the setting of recent SARS‐CoV‐2 RT‐PCR positive testing to increase physician awareness and add to the collection of cutaneous manifestations of COVID‐19.
- Published
- 2021
41. Clinical Management of Lethal Acrodermatitis Syndrome in a Bull Terrier
- Author
-
Rafael Heredia Cardenas, Camilo Romero Núñez, Laura Miranda Contreras, and Veronica Alexandra Pareja Mena
- Subjects
medicine.medical_specialty ,Bull Terrier ,business.industry ,Acrodermatitis ,medicine ,General Medicine ,business ,medicine.disease ,Dermatology - Published
- 2021
42. Gianotti‐Crosti syndrome and yellow fever vaccine: unprecedented reaction
- Author
-
Fernando E Cafrune, Stéphanie B C Leal, and Sindy Natalia Balconi
- Subjects
Vaccines ,business.industry ,Acrodermatitis ,Yellow Fever Vaccine ,Yellow fever vaccine ,Dermatology ,Gianotti–Crosti syndrome ,medicine.disease ,Virology ,medicine ,Humans ,business ,Antigens, Viral ,medicine.drug - Published
- 2020
43. Acrodermatitis continua Hallopeau successfully treated by risankizumab
- Author
-
Monika Arenbergerova, Petr Arenberger, Spyridon Gkalpakiotis, Jan Hugo, and Petra Gkalpakioti
- Subjects
medicine.medical_specialty ,Risankizumab ,Skin Diseases, Vesiculobullous ,business.industry ,Acrodermatitis ,Antibodies, Monoclonal ,Humans ,Psoriasis ,Medicine ,Dermatology ,business ,Acrodermatitis continua hallopeau - Published
- 2020
44. Caso de paraqueratosis pustulosa: entidad poco frecuente y síntoma de enfermedad inflamatoria del aparato ungueal en pacientes pediátricos
- Author
-
Teo Feuerhake Gonzalez, Francisca Beatriz Iglesias Contreras, Matias Ignacio Joaquin Carreño Osorio, and Jose Miguel Castellon Valdivieso
- Subjects
business.industry ,Acrodermatitis ,Medicine ,General Medicine ,business ,medicine.disease ,Humanities - Abstract
La paraqueratosis pustulosa es una entidad poco descrita en la literatura y se define como un proceso inflamatorio cutáneo, ungueal y periungueal en el area distal de un dedo habitualmente pulgar o indice, frecuentemente en la infancia. Su evolución suele ser benigna y la respuesta a emolientes tópicos es favorable. A continuación, se presenta un caso de esta enfermedad con el objetivo de resaltar su consideración en patologías ungueales pediátricas.
- Published
- 2020
45. A brief guide to pustular psoriasis for primary care providers
- Author
-
Paul S. Yamauchi, Jeffrey J Crowley, and David M. Pariser
- Subjects
medicine.medical_specialty ,Palmoplantar pustulosis ,030209 endocrinology & metabolism ,Primary care ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Psoriasis ,medicine ,Humans ,skin and connective tissue diseases ,Referral and Consultation ,Skin ,Primary Health Care ,business.industry ,Acrodermatitis ,Pustular psoriasis ,General Medicine ,medicine.disease ,Dermatology ,Localized disease ,Generalized pustular psoriasis ,Quality of Life ,business - Abstract
Pustular psoriasis refers to a heterogeneous group of chronic inflammatory skin disorders that are clinically, histologically, and genetically distinct from plaque psoriasis. Pustular psoriasis may present as a recurrent systemic illness (generalized pustular psoriasis [GPP]), or as localized disease affecting the palms and/or soles (palmoplantar pustulosis [PPP], also known as palmoplantar pustular psoriasis), or the digits/nail beds (acrodermatitis continua of Hallopeau [ACH]). These conditions are rare, but their possible severity and consequences should not be underestimated. GPP, especially an acute episode (flare), may be a medical emergency, with potentially life-threatening complications. PPP and ACH are often debilitating conditions. PPP is associated with impaired health-related quality of life and psychiatric morbidity, while ACH threatens irreversible nail and/or bone damage. These conditions can be difficult to diagnose; thus, primary care providers should not hesitate to contact a dermatologist for advice and/or patient referral. The role of corticosteroids in triggering and leading to flares of GPP should also be noted, and physicians should avoid the use of systemic corticosteroids in the management of any form of psoriasis.PLAIN LANGUAGE SUMMARYA brief guide to pustular psoriasis for primary care providersPustular psoriasis consists of a group of rare conditions that cause the skin to become red and painful. In these conditions, small blisters filled with pus (called pustules) appear suddenly. The pustules are not infectious. Pustular psoriasis is different from plaque psoriasis, in which people develop scaly patches of skin. People can have pustular psoriasis and plaque psoriasis at the same time. Pustular psoriasis can be widespread, affecting large areas of the body, arms, and legs. This is called generalized pustular psoriasis (GPP). GPP can cause life-threatening complications that may require emergency medical treatment. Pustular psoriasis can be more localized, occurring on the palms of the hands and soles of the feet. This is called palmoplantar pustulosis (PPP). It can also occur on the fingers, toes, and nail beds, called acrodermatitis continua of Hallopeau (ACH). PPP and ACH can make walking and other everyday activities difficult. Because GPP, PPP, and ACH are rare, primary care providers are unlikely to meet many people with pustular psoriasis, so they may not recognize these conditions immediately. This article aims to help primary care providers assess and diagnose people who may have GPP, PPP, or ACH, and advise when they should get help from a skin specialist (dermatologist). See Figure 1 for a full infographic version of this summary.
- Published
- 2020
46. Squamous cell carcinoma arising on acrodermatitis continua of Hallopeau: clinical and noninvasive skin imaging features
- Author
-
Linda Tognetti, Pietro Rubegni, Jean Luc Perrot, Francesco Santi, Cyril Habougit, and Elisa Cinotti
- Subjects
Humans ,Skin ,Acrodermatitis ,Carcinoma, Squamous Cell ,Psoriasis ,Skin Diseases, Vesiculobullous ,medicine.medical_specialty ,business.industry ,Carcinoma ,Vesiculobullous ,MEDLINE ,Dermatology ,medicine.disease ,Skin Diseases ,Squamous Cell ,medicine ,Basal cell ,business ,Skin imaging - Published
- 2020
47. Efficacy and safety of TNF blockers and of ustekinumab in palmoplantar pustulosis and in acrodermatitis continua of Hallopeau
- Author
-
Denis Jullien, Marie Aleth Richard, Julien Seneschal, F. Aubin, S. Hegazy, Michel D'Incan, E. Mahé, Coralie Barbe, Céline Girard, B. Husson, Emilie Brenaut, Hervé Bachelez, Curdin Conrad, Emilie Sbidian, M. Viguier, Centre Hospitalier Universitaire de Reims (CHU Reims), Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 (IRMAIC), Université de Reims Champagne-Ardenne (URCA), Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Dermatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, Service de Dermatologie et pathologies vasculaires [CH Argenteuil], Centre Hospitalier Victor Dupouy, Institut Laue-Langevin (ILL), ILL, Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Service de dermatologie, Hôpital Augustin Morvan-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire de biologie cellulaire et moléculaire, Institut National de la Recherche Agronomique (INRA), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Robert Debré, CRCM, Université Paris7, Assistance Publique - Hôpitaux de Paris, Département de dermatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
- Subjects
Male ,medicine.medical_specialty ,Palmoplantar pustulosis ,[SDV]Life Sciences [q-bio] ,education ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Dermatology ,Gastroenterology ,Etanercept ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,Internal medicine ,Ustekinumab ,parasitic diseases ,Adalimumab ,medicine ,otorhinolaryngologic diseases ,Humans ,ComputingMilieux_MISCELLANEOUS ,Retrospective Studies ,business.industry ,Acrodermatitis ,Odds ratio ,medicine.disease ,Infliximab ,3. Good health ,Infectious Diseases ,030220 oncology & carcinogenesis ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Tumor Necrosis Factor Inhibitors ,business ,medicine.drug - Abstract
Background Palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH) are rare variants of psoriasis. Knowledge of the efficacy of biologics is scarce. Objectives To evaluate the real-life efficacy of tumour necrosis factor blockers and ustekinumab in PPP and in ACH. Methods A multicentre retrospective descriptive study was conducted in 19 dermatology departments, including all patients with PPP or ACH seen from 2014 to 2016 who received one of the studied biologics. The data were collected by a standardized document. Factors associated with complete clearance (CC) were analysed by multivariate analysis, estimating odds ratios (ORs) and 95% confidence intervals (CIs). Results Among 92 patients included, 50 received adalimumab, 44 ustekinumab, 36 etanercept and 31 infliximab. Improvement and CC were observed in 83.9% and 20.0% patients receiving infliximab, 75.0% and 38.6% ustekinumab, 57.1% and 20.0% etanercept and 60.4% and 29.2% adalimumab. We found no significant difference in CC rates or duration of treatment among the biological treatments (P = 0.18 and P = 0.10, respectively). On multivariate analysis, CC with etanercept was associated with the ACH form and not smoking [OR = 9.5 (95% CI 1.1-82.7), P = 0.04 and 0.1 (0.01-0.9), P = 0.04]; with ustekinumab, male sex and absence of obesity [6.0 (1.3-28.6), P = 0.02 and 4.7 (1.0-22.7), P = 0.05]; with adalimumab, the ACH form [11.9 (2.7-52.3), P = 0.001]; and with infliximab, obesity [5.6 (1.1-29.4), P = 0.04]. Conclusions We found no difference in efficacy between TNF blockers and ustekinumab and among the three different TNF blockers in real life for PPP or ACH, which reveals the heterogeneity of clinical response to biologics in pustular psoriasis as compared with plaque psoriasis.
- Published
- 2020
48. Brodalumab in the treatment of recalcitrant acrodermatitis continua of Hallopeau
- Author
-
Federico Bardazzi, Ambra Di Altobrando, Rossella Lacava, and Alessandro Pileri
- Subjects
medicine.medical_specialty ,Skin Diseases, Vesiculobullous ,business.industry ,Acrodermatitis ,Brodalumab ,Dermatology ,General Medicine ,Antibodies, Monoclonal, Humanized ,medicine.disease ,Monoclonal ,Humans ,Psoriasis ,Medicine ,business - Published
- 2020
49. Diagnostic workup of acroangiodermatitis of Mali (pseudo-Kaposi sarcoma) demasking metastasized epithelioid angiosarcoma
- Author
-
Holger A. Haenssle, Alexander Enk, Lukas Trennheuser, Christine Fink, and Ferdinand Toberer
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Acrodermatitis ,Hemangiosarcoma ,Epithelioid Angiosarcoma ,Dermatology ,Skin Diseases, Vascular ,medicine.disease ,Mali ,Diagnosis, Differential ,Medicine ,Humans ,Sarcoma ,Acroangiodermatitis ,business ,Sarcoma, Kaposi - Published
- 2020
50. Acquired Acrodermatitis Enteropathica
- Author
-
Kamal Kant Sahu, Ajay Kumar Mishra, Jennifer Sargent, and Anu Anna George
- Subjects
Acquired acrodermatitis enteropathica ,Adult ,medicine.medical_specialty ,business.industry ,Depression ,Substance-Related Disorders ,Acrodermatitis ,MEDLINE ,General Medicine ,Dermatology ,Hepatitis C ,Zinc ,Pancreatitis, Chronic ,medicine ,Humans ,Female ,business - Published
- 2020
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