1. The role of fibroblast growth factor 19 in pathogenesis of bile acid diarrhea of the patients who underwent cholecystectomy
- Author
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L. Кh. Indeykina, Е. А. Sabelnikova, G. G. Varvanina, S. U. Silvestrova, А. V. Smirnova, L. М. Krums, A. A. Viaznikova, and А. I. Parfenov
- Subjects
History ,medicine.medical_specialty ,Malabsorption ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gastroenterology ,Excretion ,03 medical and health sciences ,0302 clinical medicine ,Blood serum ,Internal medicine ,medicine ,Feces ,bile acids ,fibroblast growth factor 19 ,Bile acid ,business.industry ,bile acid diarrhea ,FGF19 ,General Medicine ,medicine.disease ,Diarrhea ,030220 oncology & carcinogenesis ,postcholecystectomy syndrome ,Medicine ,030211 gastroenterology & hepatology ,Cholecystectomy ,medicine.symptom ,Family Practice ,business - Abstract
The occurrence of chronic diarrhea after cholecystectomy (CCY) has been described by many researchers. However, the main mechanisms of the development of this diarrhea are not fully understood. Supposed that dysregulation of the bile acids (ВA) absorption in the ileum is played a significant role in the development of diarrhea syndrome. Aim. To determine the role of the fibroblast growth factor 19 (FGF19) level in the serum and BA concentration in feces in pathogenesis of bile acid diarrhea (ВАD) in patients after CCY. Materials and methods . Sixty-one patients were examined at various times after CCY: 30 patients with chronic diarrhea that appeared after CCY (group 1) and 31 patients with normal stools (group 2). In all patients, the level of FGF19 in the blood serum, and the daily excretion of BA in the feces were studied. The control group consisted of 28 healthy individuals. Results . In the 1st group we found lower concentrations of FGF19 in the blood serum 86.2 ng/ml (67.8; 117.8) compared with concentrations in the 2nd group – 259 ng/ml (170.6; 318.8), p
- Published
- 2021