1. Biopsy-Proven Lymphocytic Myocarditis With Heart Failure in a Middle-Aged Female Patient With Mixed Connective Tissue Disease
- Author
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Sabino Iliceto, Stefania Rizzo, Cristina Basso, Chun-Yan Cheng, Stefano Figliozzi, Renzo Marcolongo, and Alida L.P. Caforio
- Subjects
LVEF ,MTP ,medicine.medical_treatment ,Cardiomyopathy ,Case Report ,left ventricle ejection fraction ,LVEF, left ventricle ejection fraction ,AIDA, anti-intercalated autoantibodies ,SID, systemic immune mediated disease ,Mixed connective tissue disease ,AHA, anti-heart autoantibodies ,CMR, cardiac magnetic resonance ,EMB ,Troponin I ,Medicine ,MMF ,CMR ,anti-intercalated autoantibodies ,AIDA ,SID ,biology ,Immunosuppression ,anti-heart autoantibodies ,chronic heart failure ,MTP, methylprednisolone ,systemic immune mediated disease ,EMB, endomyocardial biopsy ,cardiovascular system ,Cardiology ,mixed connective tissue disease ,HRCT, high-resolution chest computed tomography ,MCTD, mixed connective tissue disease ,MMF, mycophenolate mofetil ,autoimmune ,cardiomyopathy ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Asymptomatic ,cardiac magnetic resonance ,Clinical Case ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,business.industry ,mycophenolate mofetil ,medicine.disease ,Troponin ,methylprednisolone ,RC666-701 ,AHA ,Heart failure ,endomyocardial biopsy ,Heart catheterization ,HRCT ,biology.protein ,MCTD ,high-resolution chest computed tomography ,business - Abstract
A 56-year-old woman with mixed connective tissue disease, who was on maintenance immunosuppression, developed asymptomatic left ventricular…, A 56-year-old woman with mixed connective tissue disease, who was on maintenance immunosuppression, developed asymptomatic left ventricular dysfunction, ventricular arrhythmia, and high troponin I. Heart catheterization showed normal coronaries and biopsy-proven, virus-negative lymphocytic myocarditis. A biopsy-guided immunosuppression upgrade effectively treated autoimmune myocarditis, which resulted in ventricular function recovery, resolution of arrhythmia, and of troponin release. (Level of Difficulty: Advanced.), Graphical abstract
- Published
- 2019
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