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A Vector Finder approach for track reconstruction developed for the Inner Tracking System of the MPD experiment is described, including primary and secondary track reconstruction and track matching algorithms. Preliminary results of their application for the tasks of track reconstruction and track matching are presented for Monte Carlo simulated central Au + Au events at $$\sqrt {{{s}_{{NN}}}} = 9$$ GeV.

As a part of the future upgrade program of the Multi-Purpose Detector (MPD) experiment at the Nuclotron-Based Ion Collider Facility (NICA) complex, an Inner Tracking System (ITS) made of Monolitic Active Pixel Sensors (MAPSs) is proposed between the beam pipe and the Time Projection Chamber (TPC). It is expected that the new detector will enhance the experimental potential for the reconstruction of short-lived particles—in particular, those containing the open charm particle. To study the detector performance and select its best configuration, a track reconstruction approach based on a constrained combinatorial search was developed and implemented as a software toolkit called Vector Finder. This paper describes the proposed approach and demonstrates its characteristics for primary and secondary track finding in ITS, ITS-to-TPC track matching and hyperon reconstruction within the MPD software framework. The results were obtained on a set of simulated central gold–gold collision events at sNN=9 GeV with an average multiplicity of ∼1000 charged particles in the detector acceptance produced with the Ultra-Relativistic Quantum Molecular Dynamics (UrQMD) generator.

The article describes the role of the dual education system as a guarantee of social partnership in improving the quality of professional training of graduates of higher educational institutions. The dual education systems of the world (Germany, France, Denmark, Japan, South Korea) for professional training of university graduates in accordance with modern requirements of employers, who acquire the features of national models of functioning, and that there is no single reference model of dual education. The scheme of dual education is proposed as an innovative type of organization of targeted professional training of students in the Nikopol region, in Ukraine, which is a coordinated cooperation of universities and employers in the training of competitive professionals. Social partnership is seen as a social dialogue carried out in the form of cooperation, which facilitates the transition of professional training of competitive university graduates to a qualitatively new level of training. The introduction of a dual form of education to ensure a rapid response to changes in the labor market, and this is possible only by creating a system of social partnership, improving the training of graduates to organize social partnership, while maintaining the best traditions of higher education. Approbation of dual education as a guarantee of social partnership in the professional training of graduates was carried out on the basis of the National Metallurgical Academy of Ukraine (Nikopol Faculty and Nikopol Vocational College). The study covered from 2016 to 2020 about 1,600 students. Based on the results of the analysis of foreign experience of dual education as a guarantee of social partnership of higher education institutions with employers, it can be argued about various forms of interaction (development of educational institution strategy with enterprises, implementation of graduate career tracking system, etc.). -production process. Social partnership is considered as a social dialogue carried out in the form of cooperation, which will facilitate the transition of professional training of educational institutions to a qualitatively new level of training of competitive graduates. The implementation of the dual system contributes to the development of an effective system of social partnership of universities with basic enterprises. The dual system as a guarantee of social partnership in the professional training of graduates of higher educational institutions is socially significant for the functioning, support and development of Ukraine, requires a clear appropriate state policy.

A track reconstruction method based on a constrained combinatorial search for track candidates, i.e. combinations of detector hits possibly belonging to a track, is presented. The algorithm has been implemented as a Vector Finder software toolkit containing a track reconstruction procedure and tools to determine hit acceptance windows (a priori constraints) for the track search. Track reconstruction results for high multiplicity simulated events (∼1000 particles in the detector acceptance) are shown demonstrating good performance of the approach proposed.

Introduction: Automation of business documentation workflow in medical practice substantially accelerates and improves the process and results in better service development. Methods: Efficient use of databases, data banks, and document-oriented storage (warehouses data), including dual-purpose databases, enables performing specific actions, such as adding records, introducing changes into them, performing an either ordinary or analytical search of data, as well as their efficient processing. With the focus on achieving interaction between the distributed and heterogeneous applications and the devices belonging to the independent organizations, the specialized medical client application has been developed, as a result of which the quantity and quality of information streams of data, which can be essential for effective treatment of patients with breast cancer, have increased. Results: The application has been developed, allowing automating the management of patient records, taking into account the needs of medical staff, especially in managing patients’ appointments and creating patient’s medical records in accordance with the international standards currently in force. This work is the basis for the smoother integration of medical records and genomics data to achieve better prevention, diagnosis, prediction, and treatment of breast cancer (oncology). Conclusion: Since relevant standards upgrade the functioning of health care information technology and the quality and safety of patient’s care, we have accomplished the global architectural scheme of the specific medical automation system through harmonizing the medical services specified by the HL7 international.

— The paper analyzes and comments on the results of a regular survey of Russian enterprises in the real sector, which was conducted by the Institute for National Economic Forecasting of the Russian Academy of Sciences. The assessments of enterprises regarding the quality of the anticrisis policy of the state during the pandemic are presented. The information on the investment activity of Russian enterprises and on the sources of its financing is reflected. The opinions of enterprises on the importance for them of the exchange rate of the ruble against the US dollar and the euro, as well as on the desired dynamics of this rate are presented. The problem of the use of outsourcing by Russian enterprises and the presence of geographically separate subdivisions is investigated. The activity of Russian enterprises on the processing of their waste into secondary raw materials and on their use in primary production is considered.

Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic processes are the emerging microcirculation disorders due to the formation of micro-clots. An important point that aggravates the course of the disease is the development of thrombohemorrhagic syndrome. As a result, even with a variety of antibacterial drugs and the ыavailability of new treatment methods, it is often not possible to achieve positive results in the treatment of this heavy contingent of patients.Aim: to improve the effectiveness of complex therapy of patients with extensive soft tissue phlegmon by relieving thrombohemorrhagic syndrome.Materials and methods. Cryoplasma-anti-enzyme therapy in the composition of complex treatment was received by 59 (48.8 %) patients of the main group, 62 (51.2 %) patients of the comparison group received only the generally accepted treatment. In each group, there are three variants of the course of the disease – moderate, severe and septic.Results. The analysis of the clinical course of the disease showed that in patients of the first group, wounds were cleared of necrotic masses and purulent discharge with filling them with healthy granulation tissue 5.3 days faster than in the second group (p˂0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The proportion of thrombotic and thromboembolic causes of death in the first group (14.3 %) was lower than in the second (17.7 %) (p˂ 0.05).Conclusion. The use of cryoplasma-anti-enzyme therapy as part of complex treatment contributed to the effective relief of thrombohemorrhagic syndrome, the elimination of microcirculatory disorders, which allowed performing plastic closure of a wound defect 1.6 times faster, prevented the progression of multiple organ failure, and contributed to a reduction in mortality.

The growing interest both in our country and throughout the world in agriculture as an economic activity of strategic importance for ensuring food independence of the country determines the relevance of research on devising approaches to the analysis of its development using statistical methods. The authors’ approaches to assessing the development of agriculture in Russia based on data from the system of national accounts, including input-output tables, presented in this paper, make it possible to characterize the dynamics of the formation and use of output and gross value added (GVA) of the agricultural sector of the economy (including in the institutional context); assess the demand for each of the presented products within the industry and in the intermediate consumption of other industries; to identify structural changes in the composition of intermediate consumption in the production of goods; determine the trends and prospects for the development of agriculture on their basis.As part of the study, the authors disclosed additional analytical capabilities of statistical databases that include agricultural censuses and current accounting data in the system of macroeconomic indicators and allow for a more accurate assessment of the effectiveness of agricultural development. The calculated coefcients of direct costs ranged in the form of time series, analysis of the structure of intermediate consumption made it possible to identify the features of the development of the Russian agricultural sector and the directions for improving its economic and statistical analysis. The authors argue for the need to take into account the phenomenon of multistructure of agriculture in Russia to calculate the gross value added produced in the sector of peasant farms, subsidiary farms, separately small and large agricultural organizations, including holdings, with the obligatory comparison of the selling prices of their products used when calculating output and GVA. A proposal was made to include a table with additional information on labor costs and consumption of feed, fertilizers, electricity, and other basic resources in physical terms in the system of input-output tables by industry.

Context. The article proposes an approach for automated identification of the navigators motivational model in the control of water transport. Algorithms for data extraction as a result of the man-machine interaction of navigator with the electronic control systems of the vessel during performing navigation operations of increased complexity are proposed. Objective. The purpose of research is to apply formal and algorithmic approaches to extracting data on the motivational model of navigator to prevent accidents in water transport. Method. The identification of manifestation determination of navigators’ mental activity by means of the visual concept of the geometric group theory is proposed. This approach delivered the visual systematic-logical combining of diagnostic methods aimed at determining navigators motivational centers and the processes of professional activity like maneuver performing. The key indicator of identification is said to be the parameter of the navigator’s activity as “rpm_port” having an impact on the vessel speed being a marker of intensification of the navigator’s physiological activity. Such an approach is beneficial in time phase identification while maneuvering indicating explicitly at the stepping up of the navigator’s physiological motivational state. It was proven to be correct based on the results due to Ward’s dendrogram, several statistical methods and applied software. The obtained research results encourage the prediction of the navigator’ motivational states in critical situations. Results. In order to confirm the proposed formal-algorithmic approach, an experiment was carried out using the navigation simulator Navi Trainer 5000. Automated analysis of experimental ones made it possible to form a motivational map of the navigator and determine the decision-making model affecting in the processes of control vessel in difficult situations. Conclusions. The proposed research approaches made it possible to automate the processes of extracting data indicating the principles of decision-making by navigator. The effectiveness of proposed approach was substantiated by the results of experimental data automated processing and the constructed tree-like decision-making spaces.

The high mortality rate in COVID-19 can be explained by the development of a hyperinflammatory syndrome, characterized by a cytokine storm and extensive thrombus formation. The main direction for preventing the development of hyperinflammatory syndrome and reducing mortality from COVID-19 is immune therapy, however, the data on the efficacy and criteria for prescribing immune drugs is very heterogeneous. The purpose of this review is to analyze the results of clinical trials on the use of various types of immune therapy and possible criteria for its prescription. Analysis of literature data showed that the most effective among the existing variants of immune therapy were monoclonal antibodies to IL-6, the use of donor plasma in the early stages of treatment. Janus kinase inhibitors, intravenous immunoglobulin improved the clinical characteristics of patients, but did not affect the mortality rate. An analysis of possible predictor-markers of the development of a cytokine storm revealed an increase in the number of neutrophils > 11 × 103/ml, a decrease in the number of lymphocytes > 1000 × 103/ml, an increase in the level of IL-6 > 24 pg/ml, LDH > 300 IU/L, D-dimer > 1000 ng/ml, and CRP > 10 mg/dL as the most informative and accessible in clinical practice at the moment.

The article analyzes ethical issues inherent to different life-cycle stages of artificial intelligence systems and provides up-to-date information about global and domestic trends in this area. The international and national experience concerning ethical issues of artificial intelligence systems use in healthcare is described. In addition, the international and national strategies for the development of artificial intelligence in healthcare are analyzed focusing on the national development; and the main trends, similarities, and differences between strategies are identified. Furthermore, ethical components of the process of clinical trials to evaluate the safety and efficacy of artificial intelligence systems in Russia are described. Domestic state-of-the-art and globally unique experience in technical regulation of artificial intelligence systems are shown on unification papers and standardization of requirements for the development, testing, and operation of artificial intelligence systems in healthcare are presented, and unparalleled Russian experience in terms of certification requirements for artificial intelligence-based medical devices is demonstrated. The article also summarizes the main conclusions and emphasizes the importance of a strong successful healthcare system based on artificial intelligence technologies that build trust and compliance with ethical standards.

The Scientific and Educational Center "Engineering of the Future", created on the basis of the Institute of Regional Development of the Samara Region, has formed a number of important sectoral and subject committees, in which it is planned to develop breakthrough technologies in high-tech industries. The Committee on Artificial Intelligence, organized within the framework of the SEC "Engineering of the Future", forms its development strategy. The article outlines the vision for the prospects of such a strategy of the project team, consisting of specialists from universities, academia, design organizations, commercial companies and startups. The key in the proposed strategy is emergent artificial intelligence - it is a spontaneously arising, under the influence of external events or from internal causes or motives, a chain of coordinated state changes by agents who find a solution to a new problem or increase the value of an existing solution. The authors believe that the construction of emergent artificial intelligence is based on multi-agent technologies and ontologies of subject areas. The article formulates the main tasks of the Committee for the coming years and presents a technological project. The project includes the creation of mass production of intelligent resource management systems, personalized by creating digital twins of enterprise management processes, knowledge bases and multi-agent technologies. The essence of the proposed project, reflecting the important priorities of industrial partners, is to create a line of intelligent products and services for all stages of the life cycle of complex high-tech products and build a "factory" of such systems in the form of an open instrumental platform that will allow these enterprises to reduce dependence on the solution provider and on their own develop and modernize such systems. The principles of the Committee's work were proposed, its first potential projects and planned cooperation on these projects to achieve the first practical results were considered.

The article describes the experience of using photodynamic therapy in the treatment of skin metastases of a patient with breast cancer. The authors note the high effectiveness of this method of treatment in combination with safety. The obtained data allow us to conclude that photodynamic therapy is a very promising method of treating this cohort of patients. Patient K., 69 years old, was diagnosed with cancer of the left breast in October 2015. T2N3M0. Stage IIIC. Complex treatment was carried out: 2 courses of neoadjuvant chemotherapy + radical mastoectomy + remote radiation therapy summation of the focal dose 30gr + 4 courses of adjuvant chemotherapy. In the period up to February 2020, the patient repeatedly received supportive treatment in the palliative care department. Taking into account the volume of metastatic skin lesions, palliative multi-course PDT was recommended. As a result of the treatment, a partial regression of the tumor was obtained. On examination, the scar in the area of PDT is pale pink; the continued growth of the tumor is determined in the form of separate areas of infiltration along the anterior edge of the scar.

Наведений огляд літератури дозволив ознайомитися з перспективним напрямком сучасної медицини, а саме — ДНК-дослiдженнями полiморфних генiв. Виявлення структури генів, що кодують білкові молекули, а також впровадження в рутинну лабораторну практику нових діагностичних технологій зробили можливим тестування різних генних поліморфізмів, що дозволяє передбачати ризики розвитку певних захворювань у конкретного індивіда. Зокрема, генетичне тестування дозволяє з’ясувати, чи є спадкова схильність до розвитку алергічної патології, а саме — бронхiальної астми, алергiчного ринiту або атопiчного дерматиту.

Evaluation of the efficacy and safety of the modified refralon administration protocol for the relief of paroxysmal atrial fibrillation (AF).The study included 39 patients (19 men, mean age 6312.8 years). All patients, after excluding contraindications in the intensive care unit, were injected intravenously with refralon at an initial dose of 5 mg/kg. If AF was preserved and there were no contraindications, after 15 min, repeated administration was performed at a dose of 5 mg/kg (total dose of 10 mg/kg). After another 15 min, while maintaining AF and the absence of contraindications, the third injection of the drug was performed at a dose of 10 mg/kg (total dose of 20 mg/kg). In the absence of relief and the absence of contraindications, another injection of refralon at a dose of 10 mg/kg was performed after another 15 min (in this case, the maximum total dose of 30 mg/kg was reached). After each injected bolus and before the introduction of the next one, the ECG parameters and the general condition of the patient were assessed. The patient was monitored for 24 hours to exclude the arrhythmogenic effect and other possible adverse events.Restoration of sinus rhythm (SR) was noted in 37 patients out of 39 (95%). Of these, 19 people (48.7%) had SR recovery after the administration of a minimum dose of refralone of 5 mg/kg. The effectiveness of the total dose of 10 mg/kg was 76.9%, the dose of 20 mg/kg was 89.7%, and the dose of 30 mg/kg was 95%. Only two patients did not recover HR after administration of the maximum dose of refralon 30 mg/kg. Pathological prolongation of the QTc interval (500 ms) was recorded in 5% of patients. Not a single case of ventricular arrhythmogenic action (induction of Torsade de pointes) has been reported. Bradyarrhythmias (pauses, bradycardia) were registered in 13% of cases, were of a transient nature.Refralon has a high efficiency of relief (95%) of paroxysmal AF, while in almost half of cases (48.7%), SR recovery is achieved using the minimum dose of refralon 5 mg/kg. Despite the prolongation of the QTc500 ms recorded in 5% of cases, none of the patients developed Torsade de pointes after administration of the drug.Цель. Оценка эффективности и безопасности применения модифицированного протокола введения Рефралона для купирования пароксизмальной формы фибрилляции предсердий (ФП). Материалы и методы. В исследование включены 39 больных (из них 19 мужчин, средний возраст 6312,8 года). Всем пациентам после исключения противопоказаний в условиях блока интенсивной терапии вводился внутривенно Рефралон в первоначальной дозе 5 мкг/кг. При сохранении ФП и отсутствии противопоказаний через 15 мин производили повторное введение в дозе 5 мкг/кг (суммарная доза 10 мкг/кг). Еще через 15 мин при сохранении ФП и отсутствии противопоказаний производили третье введение препарата в дозе 10 мкг/кг (суммарная доза 20 мкг/кг). При отсутствии купирования и противопоказаний еще через 15 мин производили еще одно введение Рефралона в дозе 10 мкг/кг (в этом случае достигалась максимальная суммарная доза 30 мкг/кг). После каждого введенного болюса и перед введением последующего проводилась оценка параметров электрокардиограммы и общего состояния пациента. Наблюдение за пациентом продолжалось в течение 24 ч для исключения аритмогенного эффекта и других возможных нежелательных явлений. Результаты. У 37 (95%) из 39 пациентов отмечено восстановление синусового ритма (СР). Из них у 19 (48,7%) человек восстановление СР произошло после введения минимальной дозы Рефралона 5 мкг/кг. Эффективность суммарной дозы 10 мкг/кг составила 76,9%, дозы 20 мкг/кг 89,7%, дозы 30 мкг/кг 95%. Лишь у 2 пациентов восстановления СР после введения максимальной дозы Рефралона 30 мкг/кг не произошло. Патологическое удлинение интервала QTc (500 мс) регистрировалось у 5% больных. Не зарегистрировано ни одного случая желудочкового аритмогенного действия (индукции Torsade de pointes). Брадиаритмии (паузы, брадикардия) зарегистрированы в 13% случаев и носили преходящий характер. Заключение. Рефралон обладает высокой эффективностью (95%) купирования пароксизмальной формы ФП, при этом почти в 1/2 (48,7%) случаев восстановление СР достигается при использовании минимальной дозы Рефралона 5 мкг/кг. Несмотря на зарегистрированное в 5% случаев удлинение интервала QTc (500 мс), ни у одного из больных после введения препарата не отмечалось развития Torsade de pointes.

A methodology for the controlled synthesis of multifunctional coatings of valve metals by the method of micro-arc oxidation (MAO) was developed. It includes theoretical models describing the mechanism of oxide layers’ formation and the effect of technological parameters of the MAO process on them, and the methods of controlled synthesis. The latter allows us to carry out an automated selection of the optimal technological parameters of oxidation based on the obtained regression equations for the experimental dependences of the oxide layers’ properties on dissimilar influencing factors for the sake of required coating properties. We further propose the structure of an intelligent system for the synthesis and study of MAO coatings with a unique hardware. In particular, a pulsed technological current source provides a full range of regulation of the current pulses’ parameters; a measurement module combines measuring transducers of the parameters of the technological process and the electrophysical characteristics of oxide layers in the process of their obtainment with a guaranteed accuracy. The software contains an intelligent application that implements the proposed theoretical models and methods for obtaining coatings with the required properties. Information support contains databases and knowledge bases used in the operation of intelligent application. The results achieved in this work allow to increase the efficiency of MAO processing by reducing the time for selecting the optimal technological mode at least twice, which is a prerequisite for the development of an intelligent technology for the formation of oxide layers by the MAO method.

Neglect of individual features of personnel security and enterprise staff interests security affects the adequacy of assessing the general level of economic security of an enterprise, of which they both are components. It is substantiated that a system of measures of personnel KPI and personnel provision are indicators of assessing an enterprise’s staff interests. Security are a system of personnel interests of an enterprise are a system of performance indicators for KPI personnel and indicators of staffing and social benefits are indicators of economic security of the personnel. The article enhances the methodology for assessing staff interests security on the basis of calculating deficit of the earnings before tax amount which an enterprise can receive if its indicators do not reach their minimum necessary values. It is taken into account that underfunding of social programs is characterized by outstanding expenses of an enterprise the increase of which affects economic security of its personnel and intensifies the threats caused by them. Application of the suggested approach will contribute to a more effective control over the level of economic security and improve the analytical support of making managerial decisions of the financial and economic nature

Purpose. The aim of the article is substantiation and development of theoretical and methodological bases for improving the management of the system of improving the quality of higher education institutions. Methodology of research. Methods of dialectical cognition, analytical information processing, methods of comparison, grouping, graphic methods, etc. are the methodological basis for the development of theoretical and practical provisions. The following methods are used in the study: structural and logical analysis – to build the logic and structure of work; system analysis and synthesis – to study the essence of the subject of study; system approach – to improve the system and targeted approach to the management of the system of improving the quality of higher education institutions. Findings. Peculiarities of interpretation of the concept of quality system of activity of higher education institutions are investigated. The conceptual bases of management of the system of improving the quality of higher education institutions are substantiated. Theoretical and methodological bases of management of the system of improving the quality of higher education institutions are revealed and the strategy of such management is improved. The components of the system of measures and procedures in the process of ensuring the quality of higher education are presented. Originality. Provisions for the management of the process of ensuring the quality of higher education institutions in terms of developing formalized: the concept, algorithm and system of such management from a theoretical and methodological standpoint in order to more clearly implement in practice. The symbiosis of modern innovative technologies of educational process management with emphasis on effective use of intellectual capital of all employees of higher education institutions will help to improve the quality of their activities. Practical value. The theoretical and methodological principles proposed in the work on the quality management system of higher education institutions are designed to enhance the competitiveness of domestic education and can be applied by higher education institutions of all forms of ownership. Key words: quality of education, institution of higher education, quality of activity of institution of higher education.

The socio-economic development of Russia in recent years has significantly slowed down, which is caused by both external factors (a difficult geopolitical situation, sanctions wars, the economic confrontation between leading world economic powers) and internal factors (poverty, low efficiency of the economy, a weak innovation environment). In these conditions, it is necessary to find various ways to stimulate the economic and social development of the country and regions. This paper discusses the development of cooperation as a way to develop economic relations and improve living standards. The aim of the study is to reveal the relationship between consumer co-operation and the standard of living of the population, and to determine its impact on the economy. The main research methods were analysis and synthesis, generalization, and the case method. This study used data from the Federal State Statistics Service of the Russian Federation, analytical reviews on the development of cooperation in Russia, and data from the Central Union of Russia. As a result of the study, the influence of cooperation on the growth of living standards of the population has been identified, some recommendations have been made on the development of cooperation in Russia.

The pulse generators were developed to trigger the high-voltage dischargers of magnetic systems and the dischargers of the generators of pulsed voltages used by the relativistic electron beam (REB) accelerator “TEMP-B”. The description of the triggering pulse generators designed by the NSC KIPT to actuate the dischargers of the pulsed voltage generators (PVG) and the dischargers of magnetic systems has been given. These are used by the commutation systems of capacitor banks with the stored energy margin in the range of 60 to 150 kJ. The generators provide the generation of voltage pulses with the amplitude of up to 20 kV.

Analysis of the incidence of human brucellosis in the world in 2011–2020 is presented in the paper. An assessment of the epizootiological-epidemiological situation on brucellosis in the Russian Federation in 2020 is performed. It is outlined that the epidemiological situation on brucellosis in Russia over the past decade was characterized as unfavorable with downward trend in the incidence rate against the background of persistent epizootiological insecurity among cattle and small ruminants. Between 2011 and 2020, 3507 first identified human cases of brucellosis were registered. The long-term average number of cases is 350 per year, including 28 cases among children under 17 years old. The average long-term intensive morbidity rate per 100 000 people was 0.24, among children under 17 – 0.1. In 2020, 119 human cases of brucellosis were detected in Russia (0.08), which indicates that the trend towards an improvement in the epidemiological situation on brucellosis continues. The largest number of brucellosis cases among people was registered in the North-Caucasian (77.1 % of the total incidence across Russia) and the Southern Federal District (13.5 %). In the period of 2010–2020 (9 months), 4610 areas potentially hazardous as regards bovine brucellosis and 422 – as regards brucellosis in sheep and goats were registered in the Russian Federation. Analysis of the development of brucellosis situation in Russia indicates that in the medium term, with the current trend maintained, there is a real risk of widespread brucellosis distribution among farm animals in the constituent entities of the Central, Volga, Far Eastern and Siberian Federal Districts, as well as the persistence of epizootiological insecurity in the North Caucasus and Southern Federal Districts. Taking into account the current epizootiological-epidemiological situation and the long-term dynamics of the development in the Russian Federation, one can predict the incidence of brucellosis in people at a level below the longterm average values – 0.13–0.18 per 100000 of the population in 2021.

The aim – to compare the effectiveness of restoration of sinus rhythm by transesophageal pacing (TEECP) in patients with prolonged episodes of isolated typical atrial flutter (AFl) and in patients with a combination of atrial fibrillation (AF) and AFl.Materials and methods. 325 procedures of TEECP were performed in cases of longlasting episodes of AFl: from 8 days to 2 years (average 68.2±4.76 days). Prior to hospitalization, all subjects underwent ineffective medical cardioversion. The sinus rhythm was restored using TEECP, and in case of its ineffectiveness by means of electropulse therapy (EPT). All patients were divided into two groups: group I (n=237) – patients with a lone atrial flutter, and group II (n=88) – patients with the history of AF or in case of transformation AF into AFl because of antiarrhythmic therapy. Both groups were comparable by age, paroxysm duration, presence of hypertension and organic disorders of the heart conductive system, comorbidities, echocardiographic and hemodynamic parameters. Electrocardiographical parameters revealed no significant differences in the tachycardia cycle length and the average frequency of ventricular contractions.Results and discussion. Patients in the group II were characterized by a significantly longer history of arrhythmia, more severe heart failure, higher frequency of arrhythmia paroxysms and detection of thyroid disorders; recorded significantly lower amplitudes of the F wave on the surface electrocardiogram and A wave on the esophageal electrogram, which was associated with the processes of electrophysiological remodeling of the atria. Also, in contrast to patients with typical AFl, there was a significant decrease in the effectiveness of TEECP (63.6 and 89 %); more frequent use of EPT (10.2 and 3 %) and more often arrhythmia has transformed into a permanent form (25 and 7.2 %).Conclusions. In patients with prolonged episodes of typical AFl, a highly effective method of cardioversion is TEECP, regardless of the arrhythmia duration. In patients with concomitant AF, the restoration of sinus rhythm should be performed by EPT, due to its higher efficancy.

The study was aimed at determining cardiorespiratory coordination under the influence of acute hypoxia in athletes with different levels of sports qualifications. Eighteen runners aged 17 to 25 were exposed to acute (10% O2) hypoxia for 10 min. Respiration, gas exchange, and heart rate were measured during normoxia and hypoxia. The principal component (PC) analysis was used to assess cardiorespiratory coordination; the stability of PCs under the influence of hypoxia was evaluated by the Tucker’s Congruence Coefficient. The analysis was performed on a time series of 10 min of normoxia and hypoxia with the inclusion of heart rate, minute ventilation, the expired fraction of O2 and CO2. According to the level of qualification, athletes were divided into two groups: highly trained (HT, no less than category I, n = 9) and medium-trained (MT, category II, n = 9). Under normoxia, cardiorespiratory coordination in athletes of both groups was higher than in normobaric hypoxia (p = 0.001): during normoxia, the model included one PC from coordinated variables according to the Kaiser criterion in 44% of the athletes; during hypoxia, the model consisted of two PCs in 100% of the athletes. During hypoxia, the percentage of total variance explained by PC2 increased significantly (p < 0.001), regardless of the level of qualification. In hypoxia, there was a change in the variable contributions to PC1 and PC2, more pronounced in the MT group: the contribution of heart rate to PC1 increased, and the expired fraction of CO2 decreased (p < 0.001). The congruence coefficient of the first PC between normoxia and hypoxia in the HT group showed a high level of similarity (median = 0.88; 25/75% = 0.84/0.93) and was significantly (p < 0.05) higher than in MT (0.82; 0.46/0.94). Thus, highly qualified athletes have the higher cardio-respiratory stability under hypoxic exposure. This can be an additional predictive sign of good athletic performance.

The relevance of the issue, related to building an information infrastructure of technology transfer, is predetermined by the transformation of information into the most important resource of technological cooperation. At the same time, its effective functioning requires investment support on a regular basis. This paper addresses the establishment of regularities in the process of investing in the development of the information infrastructure of technology transfer and determining the rational volumes of these investments. This study was carried out in the context of the regional market, which is due to the territorial specificity of market processes, the peculiarity of information interaction among economic agents in a separate market. The study results have identified the following patterns: the lower the transaction costs of technology transfer participants, the more productive the functioning of the information infrastructure; the more active the cooperation between the participants of technology transfer, the more investment revenues in the development of this infrastructure. Taking into consideration these patterns, a simulation model of the process of investing in the development of the information infrastructure of technology transfer has been built. The proposed model was tested using an example of the real estate market in the Prydniprovskyi economic region of Ukraine. As a result of the simulation experiment, the optimal level of costs for the development of the information infrastructure for technology transfer has been established. It makes up 20% of all available investment funds in this market. The proposed model could be adapted for other regional markets. The results of this study could be useful for the system of state and regional management since they substantiate the directions of innovation policy formation and promote the development of technology transfer under the conditions of certain territorial systems

During the pandemic of novel coronavirus infection (COVID-19), computed tomography (CT) showed its effectiveness in diagnosis of coronavirus infection. However, ionizing radiation during CT studies causes concern for patients who require dynamic observation, as well as for examination of children and young people. For this retrospective study, we included 15 suspected for COVID-19 patients who were hospitalized in April 2020, Russia. There were 4 adults with positive polymerase chain reaction (PCR) test for COVID-19. All patients underwent magnetic resonance imaging (MRI) examinations using MR-LUND PROTOCOL: Single-shot Fast Spin Echo (SSFSE), LAVA 3D and IDEAL 3D, Echo-planar imaging (EPI) diffusion-weighted imaging (DWI) and Fast Spin Echo (FSE) T2 weighted imaging (T2WI). On T2WI changes were identified in 9 (60,0%) patients, on DWI - in 5 (33,3%) patients. In 5 (33,3%) patients lesions of the parenchyma were visualized on T2WI and DWI simultaneously. At the same time, 4 (26.7%) patients had changes in lung tissue only on T2WI. (P(McNemar) = 0,125; OR = 0,00 (95%); kappa = 0,500). In those patients who had CT scan, the changes were comparable to MRI. The results showed that in case of CT is not available, it is advisable to conduct a chest MRI for patients with suspected or confirmed COVID-19. Considering that T2WI is a fluid-sensitive sequence, if imaging for the lung infiltration is required, we can recommend the abbreviated MRI protocol consisting of T2 and T1 WI. These data may be applicable for interpreting other studies, such as thoracic spine MRI, detecting signs of viral pneumonia of asymptomatic patients. MRI can detect features of viral pneumonia.

Мета: враховуючи міжнародний досвід оцінити стан інтегрованості питань безпеки пацієнтів і безпеки медичного персоналу у вітчизняних лікарняних закладах та розглянути можливості посилення їх взаємозв’язку і взаємовпливу на користь мінімізації ризиків лікарняного середовища. Матеріали і методи. Проаналізовані декларації, стратегії ВООЗ, окремих країн, інші документи і тематичні наукові публікації. Досліджено вітчизняну нормативну базу і частково практику формування безпечного лікарняного середовища у 4-х закладах охорони здоров’я (ЗОЗ). Методи досліджень: бібліосемантичний, гігієнічний, системного підходу, аналітичний, статистичні та математичні. Результати. Оцінено стан інтегрованості питань безпеки пацієнтів і безпеки медичного персоналу у вітчизняних лікарняних закладах. Встановлено, що попередження випадків виробничого травматизму і інцидентів безпеки пацієнтів у вітчизняних лікарняних закладах здійснюється автономно за різними планами та програмами і є неефективним, про свідчить зростання як нещасних випадків у вітчизняних лікарняних закладах, так і стаціонарної та післяопераційної летальності. Запропоновано підходи до трансформації структури і функцій безпекових підрозділів закладів охорони здоров’я з метою формування безпечного лікарняного середовища на засадах культури безпеки. Висновки. Інтеграція питань безпеки пацієнтів та безпеки медичного персоналу у єдиних програмах є стратегічним напрямом і кращою практикою у формуванні безпечного лікарняного середовища за кордоном і її доцільно впроваджувати в нашій країні. Вітчизняна нормативна база і практика передбачає автономне і роздільне вирішення безпекових проблем щодо пацієнтів, медичного персоналу і оточуючого середовища. Трансформація структури і функцій підрозділів закладів охорони здоров’я, задіяних у забезпеченні безпеки пацієнтів, медичного персоналу, екологічної безпеки, за єдиною узгодженою стратегією сприятиме формуванню безпечного лікарняного середовища на засадах культури безпеки.

This paper is devoted to development of a risk-oriented approach to quality management during the implementation of innovative projects for strategic development of a company, which ensures the growth of effectiveness of this management. This work considers quality as the basis of company's strategic development - competitiveness and commercial effectiveness of a company are treated as the functions of quality. Due to this, focus is made not on standard and generally accessible but on unique aspects of quality, which cannot be achieved by rivals - sustainable competitive advantages. Also, this work considers the specifics of quality in the conditions of the digital economy and focuses on hi-tech character products as the basis of its quality, provided by breakthrough innovations. The risks that are inherent to innovative projects, which are implemented in entrepreneurship, are taken into account. It is offered to manage quality with their help. Based on the developed proprietary scale for classifying the levels and qualitative treatment of effectiveness of quality management during the implementation of innovative projects for company's strategic development and with the help of regression analysis it is proved that in countries with developed market economy the effectiveness of quality management during the implementation of innovative projects from the positions of company's strategic development is moderate ' not high ' thus requiring certain increase. In order to solve this problem, a risk-oriented approach to quality management during the implementation of innovative projects for company's strategic development is offered.

The article proposes tools for effective management of the trajectory of professional adaptation of military students (participants in military operations) to productive activities at a higher institution as an innovative pedagogical technology. The article identifies the practical ways to build, update and apply a set of pedagogical mechanisms for effective management of individual professional adaptation line to productive activities of students (participants in military operations) during higher education. An individual educational route is a personal program of effective management of a specialist’s professional adaptation according to his/her age and skills, interests, incentives based on an educational and professional program. The article indicates the influence of educational, training, research and organizational activities on positive dynamics of the professional adaptation line to the productive activities in the field of services of students participating in military operations. This influence is shown and reasoned by a schedule of professional adaptation line management. The article determines the conceptual framework of an integrated approach to effective management of the professional adaptation line of students participating in military operations, which is confirmed by practical effect. In our opinion, the development of the theory of productive professional activity in the field of services of a student-participants in military operations will solve this problem. The article defines the functions of effective management and improvement of the professional adaptation line. The article uses the theoretical research methods: analysis of scientific-methodical and program documentation; empirical methods: questionnaires, testing, surveys and experimental approaches, graphic and schematic interpretations.

Traditional telecommunication networks were designed for the use of specialized hardware devices (routers, Ethernet switches, etc.). These devices were created on the basis of specific hardware and software platforms of individual vendors. The deployment of such network devices has led to long cycles of design and commissioning, and, consequently, to a slowdown in the introduction of new products and services. Maintenance and management of networks of this type has been and remains quite inefficient and expensive. The sharing of SDN and NFV changes the traditional paradigm of network construction, which is how the operator designs, develops, administers the network, and provides products and services to users. Such a paradigm shift can provide many technological and operational benefits. The paradigm shift is aimed at a fundamental rethinking of the cost structure of the operator and the mode of its operational processes. This shift, when used properly, is also able to provide fast and flexible on-demand services development, which increases the operator's competitiveness in the telecommunications and information services market. The article analyzes the advantages of implementing modern technologies for virtualization of network functions. Combining SDNs with NFVs has great advantages, but the problem is their integration. In general, the article is devoted to the study of ways to integrate virtualized network functions and the SDN controller. There are two possible architectures for this integration: the SDN controller interacts with virtualized network functions (VNF) or the switch interacts with VNF. This article provides an analytical description of both options. Thus, the article aims to create a mathematical model for analytical modeling of SDN with NFV and ultimately increase productivity and accelerate the introduction of modern network technologies.