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Prostate cancer is one of the major cancers of the genitourinary tract. High-mobility group box 1 (HMGB1) was suggested as a promising therapeutic target for prostate cancer. In this study, we aim to elucidate the associations of HMGB1 single nucleotide polymorphisms (SNPs) with prostate cancer susceptibility and clinicopathological characteristics. The HMGB1 SNPs rs1412125, rs2249825, rs1045411, and rs1360485 in 579 prostate cancer patients and 579 cancer-free controls were analyzed with real-time polymerase chain reactions (real-time PCR). All of the data were evaluated with SAS statistical software. Our results showed that the HMGB1 rs1045411 T allele genotype was significantly associated with advanced pathologic T stage (odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.021‒2.012, p = 0.037) and pathologic N1 stage (OR = 2.091, 95% CI = 1.160‒3.767, p = 0.012), and the rs1360485 polymorphic CT + TT genotype was associated with pathologic Gleason grade group (4 + 5) (OR = 1.583, 95% CI = 1.017‒2.462, p = 0.041), pathologic T stage (3 + 4) (OR = 1.482, 95% CI = 1.061‒2.070, p = 0.021), and pathologic N1 stage (OR = 2.131, 95% CI = 1.178‒3.852, p = 0.011) compared with their wild-type carriers. In conclusion, our results revealed that the HMGB1 SNPs were associated with the clinical status of prostate cancer. The HMGB1 SNPs may have the potential to predict prostate cancer disease progression.

Nanophotonics has raised a great attention because detection limit can easily go down to the molecular level. Herein, we present a dark-field integrated Light-eye Technology (iLeyeT) system for monitoring of polarization-dependent surface plasmons of single shaped nanomaterials. Single shaped gold nanomaterial such as gold nanorod present both longitudinal and transverse surface plasmonic resonance under dark-field microscope. The orientation of single nanomaterials significantly tunes the direction of polarized light. We introduce a programmable light source into the dark-field microscope and image the relative peak intensities of the transverse and longitudinal surface plasmon via fast tuning wavelength. The signals from single nanomaterials can be visualized and detected by the dark-field iLeyeT system.