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Allograft functional failure due to acute or chronic rejection has long been a major concern in the area of solid organ transplantation for decades. As critical component of innate immune system, the macrophages are unlikely to be exclusive for driving acute or chronic sterile inflammation against allografts. Traditionally, macrophages are classified into two types, M1 and M2 like macrophages, based on their functions. M1 macrophages are involved in acute rejection for triggering sterile inflammation thus lead to tissue damage and poor allograft survival, while M2 macrophages represent contradictory features, playing pivotal roles in both anti-inflammation and development of graft fibrosis and resulting in chronic rejection. Macrophages also contribute to allograft vasculopathy, but the phenotypes remain to be identified. Moreover, increasing evidences are challenging traditional identification and classification of macrophage in various diseases. Better understanding the role of macrophage in chronic rejection is fundamental to developing innovative strategies for preventing late graft loss. In this review, we will update the recent progress in our understanding of diversity of macrophage-dominated innate immune response, and reveal the roles of M2 macrophages in chronic allograft rejection as well.

Background Alpha-fetoprotein (AFP) has been widely used for many years as a serum marker for hepatocellular carcinoma (HCC). However, AFP has been recognized as having poor sensitivity. More and more studies have concluded that circulating microRNAs (miRNAs) might be a promising biomarker that could complement AFP. However, the diagnostic ability of circulating miRNAs has varied among the studies. Therefore, we performed the present meta-analysis to appraise the diagnostic performance of circulating miRNAs as a biomarker for hepatitis B virus-associated HCC (HBV-HCC) patients with low AFP levels. Methods We performed a systematic review and meta-analysis of the published literature to assess the diagnostic accuracy of circulating miRNAs in differentiating HBV-HCC patients with low AFP levels from non-HCC controls. Results Circulating miRNAs showed promising potential in the diagnosis of HBV-HCC patients with low AFP levels. In the low-AFP HBV-HCC patients, the area under the curve (AUC) was 0.88 (95% confidence interval [CI]: 0.84–0.90). The pooled sensitivity and specificity were 0.84 (95% CI: 0.78–0.88) and 0.76 (95% CI: 0.69–0.83), respectively. Conclusions The detection of circulating miRNAs provides a valuable method for the diagnosis of HBV-HCC in patients with low AFP levels.

At present, the world is in the historical transformation period of global cooperation, sharing and integration, and driving a new era of electrification level. The energy structure is accelerating to evolve toward low carbon and the level of cleanliness of energy supply and consumption has increased significantly. Energy efficiency continues to increase. As is known to all that energy transformation is a social system engineering, whose fundamental task is to build a clean, low-carbon new energy system. The fundamental way is re-electrification. As a new concept, re-electrification has not yet obtained a lot of research results, and has not received extensive attention from foreign scholars. In this paper, electrification-related technologies were identified and screened, a re-electrification technology selection model was built based on DEMATEL method, which has certain significance for the subsequent advancement of re-electrification.

With the massive consumption of fossil energy, the traditional power system can no longer meet the high-quality development of the economy and society and the strict requirements of the ecological environment. The whole society urgently needs to build a new generation of power system to achieve the healthy development of the economy and society under increasingly strict constraints. For the new generation of power systems, the mainstream direction is that they should promote the deep replacement of fossil energy with electric energy in the energy consumption link, and increase the proportion of electricity in the final energy consumption and clean power generation. In addition, it should also include the informatization, intelligence and digitization of the power and even energy systems, and realize the iterative optimization of the whole system with faster communication and faster computer processing technology. In this paper, Dematel analysis method was used to identify and screen the construction elements of the new generation power system. And the role of each element in the construction process was analyzed, thus the key areas in the construction of the new generation power system were clarified.

The aim of this study was to explore the protective effects of ulinastatin (urinary trypsin inhibitor, UTI) on liver ischemia-reperfusion injury (IRI) and graft survival. We employed mouse liver cold IRI and orthotopic liver transplantation (OLTx) models. UTI was added to lactated Ringer’s (LR) solution for liver perfusion and preservationin vitroor combined with UTI injection intraperitoneally to the liver graft recipient. Our results indicated that UTI supplementation protected the liver from cold IRI in a dose-dependent manner and prolonged liver graft survival from extended cold preserved liver donors significantly. The underlying mechanism of UTI on liver IRI may be mediated by inhibition of proinflammatory cytokine release, increasing the expression of the antiapoptotic geneBcl-2and decreasing the expression of the proapoptosis genes ofCaspase-3andBax, and further protects hepatocytes from apoptotic death and improves liver function.

For the region where the renewable energy sources are more abundant and the requirement of load on power supply reliability is lower, a bilevel programming model giving priority to renewable energy is proposed, which takes environmental friendliness and economy into account. The lower level giving priority to renewable energy, which aims at maximizing the renewable energy power generation capacity, determines the size of renewable energy; The upper level ensuring the reliability of the system, which aims at minimizing the cost of the whole life cycle including the system initial investment, operation maintenance cost, fuel costs, environmental penalty cost and government subsidies, ultimately determines the optimal capacity configuration of different power sources in the system. Then a hybrid algorithm that combines the genetic algorithm with linear programming to solve this model is constructed. At last, by comparing the bilevel programming model with single layer and single target programming one, the validity and rationality of the model are fully verified, and the influence of the renewable energy penetration power limit, the cost of renewable energy units and the local climate factors on the optimization results are evaluated too.

Global energy development trends and resource endowments determine that clean substitution and electric energy substitution will be important directions for the sustainable development of world energy. Electricity has the advantages of cleanness, safety, and convenience. The implementation of electric energy substitution is of great significance to promote the energy consumption revolution, implement the national energy strategy, and promote clean energy development. At present, many provincial and municipal governments are committed to promoting electrical energy substitution to complete the energy revolution on the consumer side, which has put the local power system to the test. In this paper, a load characteristic change model based on artificial bee colony algorithm for large-scale access of electric energy substitution load is established. In addition, the power load in a typical area is used as an example, and its load change is also calculated.

Background We aimed to understand the curative effect of liposuction curettage (LC) in the treatment of bromhidrosis. Methods Relevant studies published before January 2017were searched from the PubMed, Embase, Cochrane Library, Wanfang, VIP, and China National Knowledge Infrastructure databases. Parameters including recurrence, complications, complete response, and overall response were assessed. Meta-analysis was performed using the R 3.12 statistical package. Odds ratio (OR) and 95% confidence interval (95% CI) were used for dichotomous data. Heterogeneity was assessed using Cochran's Q-statistic and I test. In addition, Egger's test was conducted to detect publication bias. Results Ten studies with a total of 1124 participants (545 cases and 579 controls) were included. There was no statistical difference in recurrence (OR = 1.19, 95% CI: 0.51-2.74), complete response (OR = 0.66, 95% CI: 0.25-1.74), or overall response (OR = 0.63, 95% CI: 0.21-1.87) between the case and control groups. The incidence of complications in the case group was lower than that in the control group (OR = 0.24, 95% CI: 0.08-0.67) and open excision group (OR = 0.11, 95% CI: 0.07-0.19). Publication bias existed for the recurrence index in the open excision group (t = 3.3979, P = .04), but no publication bias was found in other subgroups, indicating stable results. Conclusions LC, which has fewer complications, can be considered the primary choice in the treatment of patients with bromhidrosis compared with other surgical procedures.

Liver transplant is associated with the induction of peripheral immune tolerance. Liver allografts are accepted spontaneously in most combinations of mismatch in major histocompatibility complex, without any requirements for immunosuppression. Liver nonparenchymal cells (especially dendritic cells and Kupffer cells), costimulatory pathways, and activated T-cell apoptosis may contribute to the induction of liver tolerance. Therefore, liver tolerance is an active process that includes T-cell activation, proliferation, infiltration of the allograft, and T-cell apoptosis. Liver dendritic cells may modulate the amount of alloreactive T cells in liver graft recipients by expressing the coinhibitory molecule programmed death-ligand 1 and the immunosuppressive enzyme indoleamine 2,3-dioxygenase. Liver dendritic cells also may induce activated T-cell apoptosis and Foxp3+ regulatory T cells. Future studies may clarify the precise function of liver nonparenchymal cells, the interactions between programmed death-ligand 1 and other costimulatory signals, and the contribution of the liver microenvironment to the induction and expansion of Foxp 3 regulatory T cells.