334 results on '"Zhao Ming"'
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2. The Impact of Reimbursement Policy on Social Welfare, Revisit Rate, and Waiting Time in a Public Healthcare System: Fee-for-Service Versus Bundled Payment
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Guo, Pengfei, Tang, Christopher S., Wang, Yulan, and Zhao, Ming
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Medical economics -- Analysis ,Queuing theory -- Usage ,Prospective payment systems (Medical care) -- Analysis ,Business - Abstract
Abstract. This paper examines the impact of two reimbursement schemes, fee-for-service and bundled payment, on the social welfare, the patient revisit rate, and the patient waiting time in a public [...]
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- 2019
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3. Research on shrinkage development and fracture properties of internal curing pavement concrete based on humidity compensation
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Lyu, Zhenghua, Guo, Yinchuan, Chen, Zhihui, Shen, Aiqin, Qin, Xiao, Yang, Jingyu, Zhao, Ming, and Wang, Zhenlong
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Concrete pavements -- Mechanical properties -- Analysis ,Shrinkage (Materials) -- Analysis ,Polymers ,Microscopy ,Sensors ,Electron microscopy ,Business ,Construction and materials industries - Abstract
ABSTRACT In this work, we studied the moisture transfer mechanism of a superabsorbent polymer (SAP) in cement slurry, analyzed the influence of the SAP parameter on the mechanical property of [...]
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- 2019
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4. C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation
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Zhe Wang, Bin Cheng, Jian-Min Lv, Shang-Rong Ji, Xiao-Ling Liu, Hai-Yun Li, Zhao-Ming Tang, Yi Wu, Yu-Lin Liang, and Ning Gao
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Inflammation ,RC799-869 ,Pharmacology ,Mice ,Animals ,Medicine ,Receptor ,Acetaminophen ,Liver injury ,Hepatology ,biology ,business.industry ,C-reactive protein ,Pattern Recognition Receptor ,Gastroenterology ,Pattern recognition receptor ,Biomarker ,Diseases of the digestive system. Gastroenterology ,medicine.disease ,Rats ,Mice, Inbred C57BL ,C-Reactive Protein ,Editorial ,Chemical and Drug Induced Liver Injury, Chronic ,Knockout mouse ,Hepatocytes ,biology.protein ,Biomarker (medicine) ,Chemical and Drug Induced Liver Injury ,medicine.symptom ,business ,medicine.drug - Abstract
Background and aims C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI). Methods The effects of CRP in AILI were investigated using CRP knockout mice and rats combined with human CRP rescue. The mechanisms of CRP action were investigated in vitro and in mice with Fcγ receptor 2B knockout, C3 knockout, or hepatic expression of CRP mutants defective in complement interaction. The therapeutic potential of CRP was investigated by intraperitoneal administration at 2 or 6 hours post–AILI induction in wild-type mice. Results CRP knockout exacerbated AILI in mice and rats, which could be rescued by genetic knock-in, adeno-associated virus–mediated hepatic expression or direct administration of human CRP. Mechanistically, CRP does not act via its cellular receptor Fcγ receptor 2B to inhibit the early phase injury to hepatocytes induced by acetaminophen; instead, CRP acts via factor H to inhibit complement overactivation on already injured hepatocytes, thereby suppressing the late phase amplification of inflammation likely mediated by C3a-dependent actions of neutrophils. Importantly, CRP treatment effectively alleviated AILI with a significantly extended therapeutic time window than that of N-acetyl cysteine. Conclusion Our results thus identify CRP as a crucial checkpoint that limits destructive activation of complement in acute liver injury, and we argue that long-term suppression of CRP expression or function might increase the susceptibility to AILI.
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- 2022
5. Nicorandil, an ATP-sensitive potassium channel activation, attenuates myocardial injury in rats with ischemic cardiomyopathy
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Li Shaoqing, Yu Wang, Zhao Ting, Zhao Ming, Liu Hao, and Zhihui He
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ATP-sensitive potassium channel ,Myocardial Ischemia ,Pharmacology ,Pathology and Forensic Medicine ,KATP Channels ,Western blot ,medicine ,Animals ,Nicorandil ,Molecular Biology ,Ischemic cardiomyopathy ,medicine.diagnostic_test ,business.industry ,Myocardium ,General Medicine ,medicine.disease ,Potassium channel ,Rats ,Apoptosis ,Heart failure ,cardiovascular system ,Cardiomyopathies ,business ,VDAC1 ,medicine.drug - Abstract
Ischemic cardiomyopathy is a common but underestimated cause of heart failure. This study investigated the myocardial-protective effects of nicorandil on rats with ischemic cardiomyopathy. In the present study, ischemic cardiomyopathy rats model were used to evaluate the effects of nicorandil. Cardiac ultrasonography was employed to examine the changes of heart structure and heart function. Electron microscopy was employed to observe the changes of pathological ultrastructure of the myocardium. Western blot and enzyme-linked immunosorbent assays were employed to detect protein levels and Mitochondrial Ca2+ concentration. The heart color ultrasound and myocardial pathology of the rats in the nicorandil group were improved significantly, the mitochondrial Ca2+ concentration was decreased, the expressions of MFN-1, OPA-1, and Bcl were increased, and the expressions of the mitochondrial mitotic proteins DRP-1, VDAC1, CytC, and Bax were decreased in ICM rats' heart treatment with nicorandil, compared with ICM rats. Nicorandil can reduce myocardial pathological damage in ICM rats, which may be caused by promoting the opening of mitochondrial ATP-sensitive potassium channel and inducing the changes of mitochondrial dynamics to induce the reduction of myocardial cell apoptosis.
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- 2021
6. Anti-apoptotic Effect of MiR-223-3p Suppressing PIK3C2A in Cardiomyocytes from Myocardial Infarction Rat Through Regulating PI3K/Akt Signaling Pathway
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Jia Guowei, Zhao Ming, Liu Xiaoyu, and Zhang Wei
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Male ,Myocardial Infarction ,Apoptosis ,030204 cardiovascular system & hematology ,Toxicology ,Rats, Sprague-Dawley ,Andrology ,Phosphatidylinositol 3-Kinases ,03 medical and health sciences ,0302 clinical medicine ,Western blot ,medicine ,Animals ,Myocytes, Cardiac ,Ventricular remodeling ,Molecular Biology ,Protein kinase B ,Cells, Cultured ,PI3K/AKT/mTOR pathway ,TUNEL assay ,medicine.diagnostic_test ,business.industry ,Akt/PKB signaling pathway ,Transfection ,medicine.disease ,Disease Models, Animal ,MicroRNAs ,030220 oncology & carcinogenesis ,Apoptosis Regulatory Proteins ,Cardiology and Cardiovascular Medicine ,business ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
We aimed to explore the regulatory mechanism of the axis of miR-223-3p-PIK3C2A-PI3K/Akt on cardiomyocyte apoptosis in rats with myocardial infarction. Thirty 8-week-old healthy male SD rats were used for establishing the sham group and the model group, with HE staining, TUNEL staining, and TTC staining performed. After the identification of the targeting relationship between PIK3C2A and miR-223-3p, experimental rats were randomly divided into seven groups by plasmid transfection, including the Blank group, negative control (NC) group, miR-223-3p mimic group, miR-223-3p inhibitor group, siRNA-PIK3C2A group, oe-PIK3C2A group, and miR-223-3p inhibitor + oe-PIK3C2A group. Four weeks after transfection, the expression levels of miR-223-3p and PIK3C2A in tissues as well as PI3K, Akt, Bax, and bcl-2 mRNA in cells were detected by qRT-PCR and western blot, in combination with the detection of apoptosis rate by flow cytometry. Compared with the sham group, the model group showed typical myocardial injury and abnormal staining, higher apoptotic index, and larger myocardial infarction area (all P 0.05). PIK3C2A was the target gene of miR-223-3p. The expression level of miR-223-3p in model group was significantly lower than that in sham group, while the mRNA and protein expression levels of PIK3C2A increased significantly (all P 0.05). In cell tests, the expression level of miR-223-3p increased significantly in miR-223-3p mimic group (P 0.05), which, however, showed no significant change in siRNA-PIK3C2A group (P 0.05). MiR-223-3p inhibitor group and siRNA-PIK3C2A group had obviously increased PI3K, Akt, mTOR and Bcl-2 mRNA, and protein expression, while decreased mRNA and protein expression of PIK3C2A and Bax (all P 0.05); miR-223-3p mimic groups had the opposite trends (all P 0.05). siRNA-PIK3C2A + miR-223-3p mimic showed no obvious change relative to the control groups (all P 0.05). Low expression of miR-223-3p may downregulate PIK3C2A expression, resulting in the inhibition of myocardial cell apoptosis in rats with myocardial infarction via the activation of PI3K/Akt signaling pathway.
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- 2021
7. Correlation between serum renin-angiotensin system (RAS) level and depression and anxiety symptoms in patients with Parkinson's disease
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Chong-Chong Zhao, Huan Wang, Hong-Bin Cai, and Zhao-Ming Ge
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0106 biological sciences ,0301 basic medicine ,medicine.medical_specialty ,Parkinson's disease ,ACE2 ,Anxiety ,01 natural sciences ,Gastroenterology ,03 medical and health sciences ,Internal medicine ,Renin–angiotensin system ,Hamd ,medicine ,lcsh:QH301-705.5 ,AngⅠ ,Ace ,Depression (differential diagnoses) ,biology ,Depression ,business.industry ,Stomach ,Ang Ⅱ ,Angiotensin-converting enzyme ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,lcsh:Biology (General) ,biology.protein ,Original Article ,Ang (1–7) ,medicine.symptom ,General Agricultural and Biological Sciences ,business ,hormones, hormone substitutes, and hormone antagonists ,Anxiety disorder ,010606 plant biology & botany - Abstract
To investigate the correlation between serum renin-angiotensin system (RAS) level and Symptoms of anxiety and depression in Parkinson disease patients (PD). A number of 90 PD patients (47 males and 43 females) were collected on an empty stomach 12 h after stopping taking anti-PD medicines. ELISA has been found in Serum RAS ((Ang) I, Ang II, Ang (1–7), Angiotensin converting enzyme (ACE), ACE2). Depression scale (HAMD) and Anxiety scale (HAMA) in Hamilton are used for the assessment of signs of depression and anxiety. The 90 patients were diagnosed with moderate depression (HAMD score 8 ~ 19); in 32 of those (35.56 percent), and 12 (13.33%) were diagnosed as moderate and severe depression (HAMD score ≥ 20). 20 cases (22.22%) were diagnosed as possible anxiety disorder (HAMA score 7 ~ 13) and 16 cases (17.78%) as definite anxiety disorder (HAMA score ≥ 14). The association of serum Ang I, Ang II and Ang (1–7) with HAMD (r= − 0.820, P 0.05) were not associated to the serum ACE and ACE2. The serum Ang I, Ang II, and Ang (1–7) were found to be adversely associated with HAMD score (r = 0.826, P >0,001; r = −0.876, P 0.001; The HAMD score and the HAMA score (all P > 0.05) were not correlated to the serum ACE and ACE2. Finally, in PD patients, non-engine signs, including depression and anxiety, are normal. Thus, Serum levels Ang I, Ang II and Ang (1–7) were substantially decreased in female and male patients and associated with symptoms of depression and anxiety, ACE and ACE2 levels have not been attributed to signs of depression and anxiety. Serum Ang I, Ang II, and Ang (1–7) are important markers of depression and anxiety prevention and diagnosis in patients with DP.
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- 2021
8. Statistical and optimization techniques for laundry portfolio optimization at procter & gamble
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Esquejo, Nats, Miller, Kevin, Norwood, Kevin, Oliveira, Ivan, Pratt, Rob, and Zhao, Ming
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ASTM International ,Procter & Gamble Co. ,Investment analysis -- Methods ,Soap and cleaning agents industry -- Methods ,Mathematical optimization -- Methods ,Business, general ,Business - Abstract
The Procter & Gamble (P&G) fabric-care business is a multibillion dollar organization that oversees a global portfolio of products, including household brands such as Tide, Dash, and Gain. Production is [...]
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- 2015
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9. Hurricanes and climate: the U.S. CLIVAR Working Group on Hurricanes: although a theory of the climatology of tropical cyclone formation remains elusive, high-resolution climate models can now simulate many aspects of tropical cyclone climate
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Walsh, Kevin J.E., Camargo, Suzana J., Vecchi, Gabriel A., Daloz, Anne Sophie, Elsner, James, Emanuel, Kerry, Horn, Michael, Lim, Young-Kwon, Roberts, Malcolm, Patricola, Christina, Scoccimarro, Enrico, Sobel, Adam H., Strazzo, Sarah, Villarini, Gabriele, Wehner, Michael, Zhao, Ming, Kossin, James P., LaRow, Tim, Oouchi, Kazuyoshi, Schubert, Siegfried, Wang, Hui, Bacmeister, Julio, Chang, Ping, Chauvin, Fabrice, Jablonowski, Christiane, Kumar, Arun, Murakami, Hiroyuki, Ose, Tomoaki, Reed, Kevin A., Saravanan, Ramalingam, Yamada, Yohei, Zarzycki, Colin M., Vidale, Pier Luigi, Jonas, Jeffrey A., and Henderson, Naomi
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United States. Geophysical Fluid Dynamics Laboratory -- Analysis ,United States. Goddard Institute for Space Studies -- Analysis ,Climate models ,Hurricanes ,Business ,Earth sciences - Abstract
While a quantitative climate theory of tropical cyclone formation remains elusive, considerable progress has been made recently in our ability to simulate tropical cyclone climatologies and to understand the relationship [...]
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- 2015
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10. GFDL's New Simulations of Atmospheric Rivers, Their Variability, and Response to Global Warming
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Zhao, Ming
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United States. Geophysical Fluid Dynamics Laboratory -- Reports ,Global warming -- Models ,Business ,Earth sciences - Abstract
Atmospheric rivers (ARs) are long, narrow, and transient corridors of strong horizontal water vapor transport typically associated with a low-level jet stream ahead of the cold front of an extratropical [...]
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- 2021
11. Diabetes-Induced H3K9 Hyperacetylation Promotes Development of Alzheimer’s Disease Through CDK5
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Zi-Chao Li, Zhen-Zhen Fan, Ting Tian, Wen-Ting Guo, Chon-Chon Zhao, Hong-Bin Cai, and Zhao-Ming Ge
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Blood Glucose ,Male ,0301 basic medicine ,medicine.medical_specialty ,Tau protein ,Hyperphosphorylation ,Diet, High-Fat ,Diabetes Mellitus, Experimental ,Histones ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Alzheimer Disease ,Diabetes mellitus ,Internal medicine ,medicine ,Animals ,Maze Learning ,biology ,business.industry ,General Neuroscience ,Cyclin-dependent kinase 5 ,nutritional and metabolic diseases ,Acetylation ,Cyclin-Dependent Kinase 5 ,General Medicine ,Histone acetyltransferase ,Streptozotocin ,medicine.disease ,Rats ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Endocrinology ,Histone ,nervous system ,biology.protein ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The connection between diabetes and Alzheimer’s disease (AD) is not fully determined. Hyperphosphorylation of tau protein is mediated by binding and stabilization of truncated p25 with cyclin-dependent kinase-5 (CDK5) in AD. We recently showed that diabetes-associated hyperglycemia increased the CDK5 levels to promote development of AD. Here, we examined the underlying mechanisms. Hyperglycemia and glucose intolerance were induced in rats that had received a low dose of streptozotocin (STZ) and a high fat diet (HFD). Compared to the control rats that received no STZ and were fed a normal diet, the STZ + HFD rats exhibited poorer performance in the behavioral test and showed hyperacetylation of H3K9 histone on the CDK5 promoter, likely resulting from upregulation of a histone acetyltransferase, GCN5. Inhibition of acetylation of H3K9 histone by a specific GCN5 inhibitor, MB3, attenuated activation of CDK5, resulting in decreased tau phosphorylation in rat brain and improved performance of the rats in the behavior test. Thus, these data suggest that diabetes may promote future development of AD through hyperacetylation of H3K9 histone on CDK5 promoter.
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- 2020
12. Mantle cell lymphoma relapsed after autologous stem cell transplantation: a single-center experience
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Robert E. Richard, Thomas R. Chauncey, Aaron Wu, Jonathan E. Grim, Zhao Ming Dong, Solomon A. Graf, and Nicholas Burwick
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Oncology ,medicine.medical_specialty ,Mantle cell lymphoma ,Subsequent Relapse ,business.industry ,Disease progression ,Hematology ,Single Center ,medicine.disease ,chemistry.chemical_compound ,Autologous stem cell transplant ,Autologous stem-cell transplantation ,Real-world ,chemistry ,Internal medicine ,Ibrutinib ,medicine ,Original Article ,Progression-free survival ,business ,Veterans Affairs - Abstract
Background Autologous stem cell transplantation (autoSCT) can extend remission of mantle cell lymphoma (MCL), but the management of subsequent relapse is challenging. Methods We examined consecutive patients with MCL who underwent autoSCT at Veterans Affairs Puget Sound Health Care System between 2009 and 2017 (N=37). Results Ten patients experienced disease progression after autoSCT and were included in this analysis. Median progression free survival after autoSCT was 1.8 years (range, 0.3–7.1) and median overall survival after progression was only 0.7 years (range, 0.1 to not reached). The 3 patients who survived more than 1 year after progression were treated with ibrutinib. Conclusion Our findings suggest that ibrutinib can achieve relatively prolonged control of MCL progressing after autoSCT.
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- 2020
13. miR‐15a regulates oxygen glucose deprivation/reperfusion (OGD/R)‐induced neuronal injury by targeting BDNF
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Li-Jun Qin, Hao-Yue Wang, Pei Liu, Chong-Chong Zhao, Jie-Jie Hu, Hai-Ping Wei, Zhi-Yan Liu, and Zhao-Ming Ge
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Untranslated region ,Cell Survival ,Blotting, Western ,Apoptosis ,Rats, Sprague-Dawley ,Phosphatidylinositol 3-Kinases ,03 medical and health sciences ,0302 clinical medicine ,Western blot ,Neurotrophic factors ,microRNA ,Animals ,Medicine ,PI3K/AKT/mTOR pathway ,Neurons ,Messenger RNA ,lcsh:R5-920 ,medicine.diagnostic_test ,business.industry ,Brain-Derived Neurotrophic Factor ,miR‐15a ,Computational Biology ,General Medicine ,neuron ,Rats ,Cell biology ,Oxygen ,PI3K/AKT pathway ,MicroRNAs ,Glucose ,medicine.anatomical_structure ,BDNF ,nervous system ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Neuron ,business ,lcsh:Medicine (General) - Abstract
Multiple microRNAs (miRs) have also been implicated in ischemic brain injury. This research intended to probe the regulatory function and the mechanism of miR‐15a on the ischemic brain injury induced by oxygen‐glucose deprivation/reoxygenation (OGD/R) in neurons of rats. The OGD/R model was established with the cortical neurons separated from rats. After transfection with miR‐15a mimic negative control (NC), miR‐15a mimic, miR‐15a inhibitor NC and miR‐15a inhibitor, the OGD/R‐induced apoptosis were detected. Using bioinformatic softwares including TargetScan, miRanda, and miRWalk to predict the underlying targets of miR‐15a, and the binding of miR‐15a with brain‐derived neurotrophic factor (BDNF) were validated with double‐fluorescein reporter assay system. The expression levels of BDNF mRNA and protein were detected with qRT‐PCR and western blot. The effect of miR‐15a on PI3K/AKT pathway in neurons submitted to OGD/R was also investigated. The findings showed that miR‐15a may mediate the apoptosis of neurons submitted to OGD/R, and lower expression of Bcl‐2 and higher expression of Bax and cleaved caspase‐3 were observed. BDNF was screened as the candidate target, and the direct binding of miR‐15a with 3′‐UTR of BDNF were verified. Further research showed that miR‐15a downregulated the expression of BDNF mRNA and protein, thus exerted negative regulatory effect on the OGD/R injury. PI3K/AKT pathway may be related to the regulatory effect of miR‐15a. Our findings contribute to uncovering novel pathogenesis for ischemic brain injury.
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- 2020
14. A preliminary study of a novel robotic system for pedicle screw fixation: A randomised controlled trial
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Yongjian Zhu, Zhao-Ming Zhong, Jincheng Yang, Jianting Chen, Dehong Yang, Wei Huang, Shaoli Zheng, Zongze Li, Hui Jiang, Jiarui Chen, Wangsheng Jiang, Qingan Zhu, and Donghui Sun
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0301 basic medicine ,musculoskeletal diseases ,medicine.medical_specialty ,lcsh:Diseases of the musculoskeletal system ,Statistical difference ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Spine surgery ,Randomized controlled trial ,law ,Operation time ,Medicine ,Orthopedics and Sports Medicine ,Accurcay ,Pedicle screw fixation ,Pedicle screw ,Robotic system ,Conventional technique ,030203 arthritis & rheumatology ,Posterior lumbar interbody fusion ,business.industry ,Surgery ,030104 developmental biology ,Robotic systems ,surgical procedures, operative ,Preoperative planning ,Original Article ,lcsh:RC925-935 ,business - Abstract
Background and objective: Existing orthopaedic robotic systems are almost restricted to provide guidance for trajectory direction. In the present study, a novel spinal robotic system with automatic drilling power was introduced. The aim of this study is to evaluate the feasibility and safety in pedicle screw insertion of posterior lumbar interbody fusion assisted by this novel robotic system. Methods and materials: A randomised controlled trial was conducted for 17 participants who were required posterior lumbar interbody fusion process. Seven (3 M/4 F) were randomly assigned to the robot-assisted group (RA group), and the other ten (4 M/6 F) were assigned to the conventional technique group (FH group). A novel robotic system was used in the RA group. All measurements were based on postoperative computed tomography (CT) data. Accuracy of screw insertion was determined using the Gertzbein and Robbins Scale. Precision was measured by the entry point deviation distance and the trajectory rotation. Other variables included operation time, radiation time, length of stay, and screw-related complications. Result: A total of 82 pedicle screws were placed in the 17 participants. In the RA group, 90.6% of screws placed were Grade A, and 9.4% were Grade B. In the FH group, 78.0% of screws were Grade A, 20.0% were Grade B, and 2.0% were Grade C. No statistical difference was found in the operation time, radiation time per case, and length of stay between both groups. The radiation time per screw is significantly lower in the RA group. No screw-related complications or revision occurred in the present study. Conclusion: The outcome of screw accuracy of this robotic system was comparable with that of experienced surgeons, and no screw-related complication was found in the RA group during hospitalisation. In addition, radiation time per screw in the robotic group was significantly lower than that in the conventional group, which shows the potential to reduce radiation exposure of pedicle screw fixation assisted by this robotic system. Translational potential: Our study shows that pedicle screw fixation assisted by “Orthbot” system is accurate and safe. It is concluded that this novel robotic system offers a new option for internal implantation in spine surgery. Keywords: Robotic system, Pedicle screw fixation, Posterior lumbar interbody fusion, Preoperative planning, Accurcay
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- 2020
15. Oxidative Stress Contributes to Hyperalgesia in Osteoporotic Mice
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Ji-Huan Zeng, Di-Zheng Wu, Ping Xu, Ting-Ting Meng, Zhao-Ming Zhong, Jing-Shen Zhuang, Chen Tu, and Yu-Sheng Huang
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medicine.medical_specialty ,business.industry ,Osteoporosis ,TRPV1 ,Chronic pain ,Stimulation ,Calcitonin gene-related peptide ,medicine.disease ,Malondialdehyde ,medicine.disease_cause ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,Endocrinology ,chemistry ,030202 anesthesiology ,Internal medicine ,Hyperalgesia ,medicine ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Oxidative stress - Abstract
Purpose Chronic pain is one of the most common complications of postmenopausal osteoporosis. Since oxidative stress is involved in the pathogenesis of postmenopausal osteoporosis, we explored whether oxidative stress contributes to postmenopausal osteoporotic pain. Methods Osteoporosis was induced in mice by ovariectomy (OVX). Pain-related behaviours were assessed by measuring sensitivity to mechanical, thermal and cold stimulation. The expression of pain-related transcripts, such acid-sensing ion channel 3 (ASIC3), transient receptor potential vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP), was evaluated. Plasma markers of oxidative stress were also measured. In addition, the effects of the reactive oxygen species scavenger phenyl N-tert-butylnitrone (PBN) on these parameters were assessed. Results The OVX mice presented hyperalgesia, as demonstrated by decreased paw withdrawal thresholds to mechanical stimulation and withdrawal latencies to thermal and cold stimulation, along with upregulated expression of ASIC3, TRPV1 and CGRP in the dorsal root ganglia, spinal cord and thalamus tissue. OVX elevated the plasma levels of malondialdehyde (MDA) and advanced oxidation protein products (AOPPs). However, the administration of PBN alleviated these effects. Conclusion Our results indicated that oxidative stress contributes to hyperalgesia in OVX mice. Enhanced oxidative stress may be associated with osteoporotic pain. Antioxidant treatment could help alleviate chronic pain in postmenopausal osteoporotic patients.
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- 2020
16. Phase sensitivity of a three-mode nonlinear interferometer
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Li-Yun Hu, Cheng-Zhi Deng, Zhao-Ming Wu, and Chao-Ping Wei
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Physics ,Photon ,business.industry ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,010309 optics ,Nonlinear system ,Interferometry ,Optics ,Nonlinear beam ,Robustness (computer science) ,Splitter ,0103 physical sciences ,Astronomical interferometer ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,0210 nano-technology ,business ,Phase shift module - Abstract
In this paper, we construct the input–output relationships of a three-mode nonlinear beam splitter (TNBS) mathematically, and a set of special solutions for the input–output equations are given. By combining two TNBSs and a phase shifter, we propose a scheme for a three-mode nonlinear interferometer (TNI) and give the input–output expression of the whole TNI. Then, we study the phase sensitivity of the TNI by giving input states and detection scheme. In addition, we also calculate the phase sensitivity of a Mach–Zehnder interferometer (MZI), SU(1,1) interferometer (SU(1,1)I) and modified Mach–Zehnder interferometer (MMZI), and we discuss the relationships of phase sensitivity between the MZI, SU(1,1)I, MMZI and TNI. Finally, in the presence of photon losses, we discuss the phase sensitivity of the four different interferometers and make detailed comparisons. It is shown that the TNI has the best robustness against photon losses under certain conditions with the same parameters.
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- 2019
17. Effect of free water on the flowability of cement paste with chemical or mineral admixtures
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Zhao, Ming, Zhang, Xiong, and Zhang, Yongjuan
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Particle flow -- Analysis ,Concrete -- Mechanical properties ,Business ,Construction and materials industries - Abstract
ABSTRACT The particle packing state in cement paste and the characterization methods of free water were studied. The changes of free water in cement paste by adding mineral admixture and [...]
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- 2016
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18. Exhaled Volatile Organic Compounds for Identifying Patients With Chronic Pulmonary Aspergillosis
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Zheng-Tu Li, Pei-Ying Zeng, Zhao-Ming Chen, Wei-Jie Guan, Tong Wang, Ye Lin, Shao-Qiang Li, Zhi-Juan Zhang, Yang-Qing Zhan, Ming-Die Wang, Guo-Bin Tan, Xue Li, and Feng Ye
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Antifungal ,Medicine (General) ,medicine.medical_specialty ,medicine.drug_class ,Gastroenterology ,R5-920 ,chronic pulmonary aspergillosis ,volatile organic compounds ,Internal medicine ,medicine ,In patient ,Original Research ,business.industry ,Chronic pulmonary aspergillosis ,exhalation ,Antibody titer ,Exhalation ,General Medicine ,medicine.disease ,Serum samples ,metabolomics ,single-photon ionization-mass spectrometry ,Pneumonia ,Medicine ,Differential diagnosis ,business - Abstract
Background: Diagnosing chronic pulmonary aspergillosis is a major challenge in clinical practice. The development and validation of a novel, sensitive and specific assay for diagnosing chronic pulmonary aspergillosis is urgently needed.Methods: From April 2018 to June 2019, 53 patients with chronic pulmonary aspergillosis (CPA), 32 patients with community-acquired pneumonia (CAP) and 48 healthy controls were recruited from the First Affiliated Hospital of Guangzhou Medical University. Clinical characteristics and samples were collected at enrollment. All exhaled breath samples were analyzed offline using thermal desorption single-photon ionization time-of-flight mass spectrometry; to analyze the metabolic pathways of the characteristic volatile organic compounds, serum samples were subjected to ultrahigh-performance liquid chromatography.Results: We identified characteristic volatile organic compounds in patients with chronic pulmonary aspergillosis, which mainly consisted of phenol, neopentyl alcohol, toluene, limonene and ethylbenzene. These compounds were assessed using a logistic regression model. The sensitivity and specificity were 95.8 and 96.9% for discriminating patients in the CPA group from those in the CAP group and 95.8 and 97.9% for discriminating patients in the CPA group from healthy controls, respectively. The concentration of limonene (m/z 136) correlated significantly positively with anti-Aspergillus fumigatus IgG antibody titers (r = 0.420, P < 0.01). After antifungal treatment, serum IgG and the concentration of limonene (m/z 136) decreased in the subgroup of patients with chronic pulmonary aspergillosis.Conclusions: We identified VOCs that can be used as biomarkers for differential diagnosis and therapeutic response prediction in patients with chronic pulmonary aspergillosis.
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- 2021
19. Severe and prolonged cyclophosphamide-induced hepatotoxicity in a breast cancer patient carrying a CYP2B6*7 variant
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Xu Yan, Tian Xiaoxin, Zhao Ming, Zhang Yongqiang, Zhang Zijin, and Chen Di
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Pharmacology ,Oncology ,medicine.medical_specialty ,Chemotherapy ,Cyclophosphamide ,CYP2B6 ,business.industry ,medicine.medical_treatment ,medicine.disease ,030226 pharmacology & pharmacy ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,030220 oncology & carcinogenesis ,Internal medicine ,Genetics ,Molecular Medicine ,Medicine ,Allele ,business ,Adverse effect ,Genotyping ,Pharmacogenetics ,medicine.drug - Abstract
As a widely used alkylating agent, cyclophosphamide often leads to various toxicities. Severe hepatotoxicity has been rarely reported in breast cancer patients receiving chemotherapy containing cyclophosphamide. Differences in cyclophosphamide metabolism may contribute to variability in adverse events of patients. Here, we report on a case of a 68-year-old Chinese female with breast cancer who experienced severe and prolonged hepatotoxicity induced by cyclophosphamide. Pharmacogenetic tests showed that she was a carrier of CYP2B6*7 allele and this is the first case of a CYP2B6*7 variant in the Han Chinese population so far reported. In addition, the patient was also a carrier of an ALDH3A1*2 variant potentially contributing to the occurrence of hepatotoxicity. CYP2B6 and ALDH3A1 genotyping may play a role in guiding cyclophosphamide therapy.
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- 2019
20. Predictors for Poor Outcomes After Percutaneous Endoscopic Lumbar Discectomy: A Retrospective Study of 241 Patients
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Jianting Chen, Xing Shen, Qian Wu, Zhao-Ming Zhong, Shuai Zheng, and Zetao Shen
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Adult ,Male ,medicine.medical_specialty ,Percutaneous ,Physical examination ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Rating scale ,medicine ,Back pain ,Humans ,Diskectomy, Percutaneous ,Retrospective Studies ,Lumbar Vertebrae ,medicine.diagnostic_test ,business.industry ,Endoscopy ,Modic changes ,Retrospective cohort study ,Middle Aged ,Oswestry Disability Index ,Surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Intervertebral Disc Displacement ,030217 neurology & neurosurgery - Abstract
Percutaneous endoscopic lumbar discectomy (PELD) is a popular surgical procedure for the treatment of lumbar disc herniation (LDH). However, a small proportion of patients will have poor surgical outcomes. We sought to identify the predictors for poor outcomes after PELD.A total of 241 patients who had undergone PELD were followed up. Their numerical rating scale (NRS) for pain and Oswestry Disability Index scores were analyzed. They were divided by outcome (excellent, good, fair, poor) using the MacNab criteria. Their clinical history, physical examination, imaging, and surgical findings were compared among the groups. Ordinal logistic regression analysis was used to identify independent predictors for poor outcomes.The preoperative mean total NRS for back pain, NRS for leg pain, and Oswestry Disability Index scores were 4.3 ± 2.6, 5.6 ± 2.5, and 52.1% ± 23.0%. At 2 years after PELD, the corresponding scores had decreased to 1.2 ± 1.7, 0.9 ± 1.5, and 8.4% ± 11.2% (P0.001). The excellent, good, fair, and poor outcome rates were 44.4%, 31.5%, 17.4%, and 6.6%, respectively. Ordinal logistic regression analysis revealed that 2-level PELD (P = 0.001), a history of lumbar fusion (P = 0.007), and Modic changes (P = 0.011) were independent predictors for poor outcomes. Numbness was an independent predictor for excellent outcomes (P = 0.014).PELD appears to be an effective surgery for LDH. Two-level PELD, a history of lumbar fusion, and Modic changes at the same level were independent predictors for poor outcomes after PELD. Patients with LDH with numbness were more likely to have excellent outcomes.
- Published
- 2019
21. Is anterior decompression and fusion superior to laminoplasty for cervical myelopathy due to ossification of posterior longitudinal ligament? A systematic review and meta-analysis
- Author
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Jianting Chen, Yu-Sheng Huang, Zhao-Ming Zhong, Jing-Shen Zhuang, and Ping Xu
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Reviews ,Context (language use) ,Ossification of Posterior Longitudinal Ligament ,Spinal Cord Diseases ,Laminoplasty ,03 medical and health sciences ,Myelopathy ,0302 clinical medicine ,Osteogenesis ,medicine ,Humans ,Posterior longitudinal ligament ,Spinal Cord Injuries ,Retrospective Studies ,030222 orthopedics ,business.industry ,Ossification ,Anterior decompression ,Surgical procedures ,Decompression, Surgical ,medicine.disease ,Longitudinal Ligaments ,Surgery ,Spinal Fusion ,Treatment Outcome ,Meta-analysis ,Cervical Vertebrae ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Context: Considerable controversy exists over surgical procedures for ossification of the posterior longitudinal ligament (OPLL). Objective: The purpose of the meta-analysis was to compare the clinical outcome of anterior decompression and fusion (ADF) with laminoplasty (LAMP) in treatment of cervical myelopathy due to OPLL. Methods: PubMed, EMBASE and the Cochrane Register of Controlled Trials database were searched to identify potential clinical studies compared ADF with LAMP for cervical myelopathy owing to OPLL. We also manually searched the reference lists of articles and reviews for possible relevant studies. Thirteen studies with 1120 patients were included in our analysis. Subgroup analyses were performed by the canal occupying ratio of OPLL. Results: Overall, the mean preoperative Japanese Orthopaedic Association (JOA) score was similar between two groups. Compared with LAMP group, ADF group was higher at the mean postoperative JOA scores and mean recovery rate, reoperation rate, and longer at mean operation time. There was not significantly different in mean blood loss and complication rate between two groups. In subgroup analysis, ADF had a higher mean postoperative JOA score and recovery rate than LAMP in cases of OPLL with occupying ratios ≥ 50%, while those difference were not found in cases of OPLL with occupying ratios < 50%. Conclusion: ADF achieves better neurological improvement compared with LAMP in treatment of cervical myelopathy due to OPLL, especially in cases of OPLL with occupying ratios ≥ 50%. Complication rate is similar between two groups, but ADF can increase the risk of reoperation
- Published
- 2019
22. Large Signal LD Side-pumped Nd∶YAG Laser Amplifier Without Water-cooler
- Author
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徐爱东 Xu Ai-dong, 刘友强 Liu You-qiang, 王聪聪 Wang Cong-cong, 王智勇 Wang Zhiyong, 闫岸如 Yan An-ru, 刘学胜 Liu Xuesheng, 赵 明 Zhao ming, 邹吉跃 Zou Ji-yue, and 杨 松 Yang Song
- Subjects
Radiation ,Materials science ,Water cooler ,business.industry ,Nd:YAG laser ,Amplifier ,Optoelectronics ,Condensed Matter Physics ,business ,Signal ,Electronic, Optical and Magnetic Materials - Published
- 2019
23. Generation of high-energy pulses in dispersion-managed Tm-doped fiber laser
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Wang Tianshu and Zhao Ming
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High energy ,Materials science ,business.industry ,Fiber laser ,Doping ,Dispersion managed ,Optoelectronics ,business ,Atomic and Molecular Physics, and Optics - Published
- 2019
24. Characterization of the reservoir property time-variation based on ‘surface flux’ and simulator development
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Yu Jiang, Jing Hua, Tao Ziqiang, Wei Zhang, Ni Tianlu, Jianchun Xu, Zhao Ming, Yongzheng Cui, Ruizhong Jiang, Mingjun Cai, and Pingqi Zhao
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Commercial software ,Computer simulation ,business.industry ,020209 energy ,General Chemical Engineering ,Water injection (oil production) ,Organic Chemistry ,Energy Engineering and Power Technology ,02 engineering and technology ,010502 geochemistry & geophysics ,01 natural sciences ,Petroleum reservoir ,Fuel Technology ,Software ,0202 electrical engineering, electronic engineering, information engineering ,Fluid dynamics ,Environmental science ,business ,Relative permeability ,History matching ,Simulation ,0105 earth and related environmental sciences - Abstract
Many conventional reservoirs use water flooding to displace oil and supply energy to the formation. However, previous studies have established that water injection influences the pore structure of the reservoir rock, and thus, many important physical properties change with time during development. Most reservoir simulators neglect the alteration of reservoir properties during simulation, and thus, fail to reflect the real dynamic of the fluid flow and production performance. In this paper, a new parameter known as surface flux is introduced to continuously characterize the time-variation of a property during simulation. This new method overcomes the disadvantage of the previous characterization approach, which is strongly dependent on grid size. A new numerical simulation software in which reservoir properties are considered functions of surface flux is developed based on the black oil model, and the new simulator is validated against commercial software. Additionally, the proposed method is validated in overcoming the disadvantage of the latest approach, which is dependent on grid size. Furthermore, the time-variation effects of different parameters are investigated, and the ultimate oil recovery of the synthetic reservoir is found to increase when taking the time-variation of the relative permeability curve into account, whereas the ultimate recovery of the synthetic reservoir declines when the time-variation of the absolute permeability is incorporated. Eventually, the newly developed simulator is applied to a real water flooding reservoir to illustrate how this simulator can facilitate the history matching process and enhance the numerical model reliability. The field water cut predicted with the traditional black oil simulator after history matching is higher than that of the real production, which is because the time-variation mechanism is neglected. The water cut obtained by our simulator after history matching can readily match the actual data because it successfully represents the variation in the reservoir properties during production.
- Published
- 2018
25. Application of Immune Infiltration Signature and Machine Learning Model in the Differential Diagnosis and Prognosis of Bone-Related Malignancies
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Guo-Qi Li, Yi-Kai Wang, Hao Zhou, Lin-Guang Jin, Chun-Yu Wang, Mugahed Albahde, Yan Wu, Heng-Yuan Li, Wen-Kan Zhang, Bing-Hao Li, and Zhao-Ming Ye
- Subjects
immune microenvironment ,Context (language use) ,Metastasis ,Cell and Developmental Biology ,Immune system ,bone metastases ,osteosarcoma ,medicine ,lcsh:QH301-705.5 ,Multiple myeloma ,Original Research ,business.industry ,Cancer ,Ewing's sarcoma ,Cell Biology ,medicine.disease ,multiple myeloma ,lcsh:Biology (General) ,Cancer research ,Osteosarcoma ,Sarcoma ,Ewing’s sarcoma ,ssGSEA ,business ,random forest ,Developmental Biology - Abstract
Bone-related malignancies, such as osteosarcoma, Ewing’s sarcoma, multiple myeloma, and cancer bone metastases have similar histological context, but they are distinct in origin and biological behavior. We hypothesize that a distinct immune infiltrative microenvironment exists in these four most common malignant bone-associated tumors and can be used for tumor diagnosis and patient prognosis. After sample cleaning, data integration, and batch effect removal, we used 22 publicly available datasets to draw out the tumor immune microenvironment using the ssGSEA algorithm. The diagnostic model was developed using the random forest. Further statistical analysis of the immune microenvironment and clinical data of patients with osteosarcoma and Ewing’s sarcoma was carried out. The results suggested significant differences in the microenvironment of bone-related tumors, and the diagnostic accuracy of the model was higher than 97%. Also, high infiltration of multiple immune cells in Ewing’s sarcoma was suggestive of poor patient prognosis. Meanwhile, increased infiltration of macrophages and B cells suggested a better prognosis for patients with osteosarcoma, and effector memory CD8 T cells and type 2 T helper cells correlated with patients’ chemotherapy responsiveness and tumor metastasis. Our study revealed that the random forest diagnostic model based on immune infiltration can accurately perform the differential diagnosis of bone-related malignancies. The immune microenvironment of osteosarcoma and Ewing’s sarcoma has an important impact on patient prognosis. Suppressing the highly inflammatory environment of Ewing’s sarcoma and promoting macrophage and B cell infiltration may have good potential to be a novel adjuvant treatment option for osteosarcoma and Ewing’s sarcoma.
- Published
- 2021
26. Automatically compiling bilingual legal glossaries based on Chinese–English parallel corpora
- Author
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Zhao-Ming Gao
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Matching (statistics) ,Phrase ,Machine translation ,Computer science ,business.industry ,Terminology extraction ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,computer.software_genre ,Noun phrase ,Parallel corpora ,Error analysis ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Artificial intelligence ,business ,computer ,Word (computer architecture) ,Natural language processing - Abstract
Bilingual legal glossaries are indispensable to translators in specialized and technical translations. However, manual construction of such resources is very time-consuming. This chapter explores the methods of automatically compiling bilingual legal glossaries based on parallel Chinese–English legal corpora of 600,000 words by integrating state-of-the-art tools in machine translation and natural language processing. It investigates the pros and cons of linguistic and statistical approaches to bilingual terminology extraction as well as neural and phrase-based statistical machine translation systems. The proposed system employs Chinese and English noun phrase recognizers, a customized phrase-based statistical system based on Moses, bilingual word and n-gram alignment tools, Google Translate, and partial matching. Our experiment shows that for a corpus size of 600,000 words, the phrase-based statistical machine translation toolkit Moses outperformed neural machine translation such as OpenNMT and Google Translate in deriving Chinese–English bilingual terminologies. Our study suggests that while terminologies tend to be fixed in the source language, their translations seem less rigid. In addition, OpenNMT, a neural MT toolkit, is found to be more sensitive to the size of the training corpus and the length of text alignment than a phrase-based statistical machine translation system such as Moses. Finally, error analysis of our customized MT system suggests that there are more missing words than redundant words.
- Published
- 2021
27. Analysis of Internet Public Opinion on 'Delayed Retirement Age'–Based on Latent Dirichlet Allocation
- Author
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Luo Yuting and Zhao Ming-qing
- Subjects
Government ,Population ageing ,Pension ,Actuarial science ,business.industry ,Information sharing ,Public opinion ,Latent Dirichlet allocation ,symbols.namesake ,Political science ,symbols ,The Internet ,business ,Retirement age - Abstract
Information sharing in the age of the Internet makes it impossible for the online public opinion to be neglected in the policy-making, analyzing and guiding the online public opinion reasonably and effectively have great significance to improving government administrative ability. “Delayed retirement age” has always been one of the hot topics in the public. Therefore, this article uses python to obtain Weibo texts, combines with the Baidu index to select the hot topics related to “delayed retirement age”, identifies three hot topics: “pension increase”, “pension insurance reform” and “ageing population”. Based on Latent Dirichlet Allocation, this article segments the Internet public opinion and selects relevant keywords under each hot topic, using text tendency analysis to analyze the public opinion from January to May in 2020. The empirical analysis of the online public opinion on the topic of “delayed retirement age” shows that the overall public opinion tendency from January to May is pessimistic. This article explains this result and gives corresponding suggestions.
- Published
- 2020
28. Projective synchronization of driving--response systems and its application to secure communication
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Li, Ke-Zan, Zhao, Ming-Chao, and Fu, Xin-Chu
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Cryptography -- Methods ,Chaos theory -- Research ,Feedback control systems -- Methods ,Business ,Computers and office automation industries ,Electronics ,Electronics and electrical industries - Published
- 2009
29. Experimental study on rapid fabrication of a 316mm aperture free-form optical mirror
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Ji-you Zhang, Jing Zhao, Zhao-ming Wang, Xu Lingdi, and Xu Chen
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Optics ,Materials science ,Fabrication ,business.industry ,Aperture ,Free form ,business - Published
- 2020
30. Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and mendelian randomization study
- Author
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Han-Qi Yang, James T. Elder, Zhi-Hua Yang, Peikuan Cong, Jiangwei Xia, Zhi-Min Ying, Ke-Qi Liu, Bin Wang, Mo-Chang Qiu, Rajan P. Nair, Zhao-Ming Ye, Pian-Pian Zhao, Wei-Yang Bai, Xiao-Wei Zhu, Jin-Qiu Zhao, Yan-Ping Zhu, Philip E. Stuart, Si-Rui Gai, Kaijing Mao, Lin Xu, Shu-Yang Xie, Bin Hu, Hou-Feng Zheng, Peng-Lin Guan, Yu-Ting Liao, and Lam C. Tsoi
- Subjects
030203 arthritis & rheumatology ,0301 basic medicine ,medicine.medical_specialty ,Bone density ,business.industry ,Immunology ,Osteoporosis ,Confounding ,Arthritis ,medicine.disease ,Logistic regression ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,Psoriatic arthritis ,030104 developmental biology ,0302 clinical medicine ,Rheumatology ,Psoriasis ,Internal medicine ,medicine ,Immunology and Allergy ,Risk factor ,business - Abstract
Objectives and methodsWith 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) and estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders were set in three ways: model0 (including age, height, weight, smoking and drinking), model1 (model0 +regular physical activity) and model2 (model1 +medication treatments). The eBMD was derived from heel ultrasound measurement. And 4904 patients with psoriasis and 847 patients with PsA were included in final analysis. Mendelian randomisation (MR) approach was used to evaluate the causal effect between them.ResultsLower eBMD were observed in patients with PsA than in controls in both model0 (β-coefficient=−0.014, p=0.0006) and model1 (β-coefficient=−0.013, p=0.002); however, the association disappeared when conditioning on treatment with methotrexate or ciclosporin (model2) (β-coefficient=−0.005, p=0.28), mediation analysis showed that 63% of the intermediary effect on eBMD was mediated by medication treatment (pConclusionsThe effect of PsA on osteoporosis was secondary (eg, medication) but not causal. Under this hypothesis, psoriasis without arthritis was not a risk factor for osteoporosis.
- Published
- 2020
31. Straighter low lumbar curvature in isthmic spondylolisthesis at L4
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Shuai Zheng, Zongze Li, Xinqiang Yao, Qingan Zhu, Si-Yuan Zhu, Jianting Chen, Shaoli Zheng, Yongjian Zhu, Congrui Liao, and Zhao-Ming Zhong
- Subjects
Pelvic tilt ,medicine.medical_specialty ,lcsh:Diseases of the musculoskeletal system ,Sports medicine ,L5 incidence ,Urology ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Rheumatology ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Lower lumbar lordosis ,Aged ,Retrospective Studies ,030222 orthopedics ,Lumbar Vertebrae ,business.industry ,Incidence (epidemiology) ,Lumbosacral Region ,Sagittal plane ,Sagittal lumbo-pelvic alignment ,Oswestry Disability Index ,Cross-Sectional Studies ,medicine.anatomical_structure ,Orthopedic surgery ,Lumbosacral angle ,Roussouly type ,Isthmic spondylolisthesis ,Spondylolisthesis ,lcsh:RC925-935 ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
Background: This study was conducted to compare differences in imaging features and clinical symptoms between patients with single-level isthmic spondylolisthesis (IS) at L4 and at L5 and to investigate the correlation between imaging and clinical parameters. Methods: This cross-sectional study evaluated patients with single-level IS who were enrolled between June 2011 and June 2018. A total of 139 patients, 44 in the L4 IS group and 95 in the L5 IS group, met the study criteria and were included. Imaging and clinical parameters obtained from the two groups were compared and analyzed.Results: Patients in the L4 IS group had smaller lower lumbar lordosis (LLL) (27.1 ± 8.2 vs. 30.9 ± 9.3, P = 0.021) and were of older age (58.5 ± 8.7 vs. 52.8 ± 10.1, P < 0.01) than those in the L5 IS group. As per the Roussouly classification system, most patients with L4 IS were classified as Type 2 (43.2%), whereas most patients with L5 IS fell under Type 3 (44.2%). In the L5 IS group, pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL), and L5 incidence (L5I) were positively associated with slippage rate (SR), but the lumbosacral angle (LSA) was negatively associated with SR (P < 0.01). In the L4 IS group, only L5I showed a positive association with SR (P < 0.01). More significant associations were found among sagittal lumbo-pelvic parameters in the L5 IS group, but none were found between SR and Oswestry Disability Index (ODI) in either group.Conclusions: When compared with patients with L5 IS, patients with L4 IS were of older age and had straighter low lumbar curvature when they were obviously symptomatic. PI was an important parameter for patients with L5 IS while for those with L4 IS, L5I deserved more attention for its significantly positive correlation with the degree of slippage.
- Published
- 2020
32. M2-Like Microglia Polarization Attenuates Neuropathic Pain Associated with Alzheimer's Disease
- Author
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Chong-Chong Zhao, Zhi-Yan Liu, Zhao-Ming Ge, Jing Jin, Jia Guo, Hong-Bin Cai, and Huan Wang
- Subjects
0301 basic medicine ,Small hairpin RNA ,03 medical and health sciences ,Mice ,0302 clinical medicine ,In vivo ,Alzheimer Disease ,medicine ,Animals ,Humans ,Secretion ,Microglia ,business.industry ,General Neuroscience ,General Medicine ,Phenotype ,In vitro ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,medicine.anatomical_structure ,Neuropathic pain ,DNMT1 ,Cancer research ,Cytokines ,Neuralgia ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Many Alzheimer's disease (AD) patients suffer from persistent neuropathic pain (NP), which is mediated, at least partially, but microglia. Nevertheless, the exact underlying mechanism is unknown. Moreover, a clinically translatable approach through modulating microglia for treating AD-associated NP is not available. Here, in a doxycycline-induced mouse model (rTg4510) for AD, we showed development of NP. We found that the total number of microglia in the CA3 region was not increased, but polarized to pro-inflammatory M1-like phenotype, with concomitant increases in production and secretion of pro-inflammatory cytokines. To examine whether this microglia polarization plays an essential role in the AD-associated NP, we generated an adeno-associated virus (AAV) serotype PHP.B (capable of crossing the blood-brain barrier) carrying shRNA for DNA methyltransferase 1 (DNMT1) under a microglia-specific TMEM119 promoter (AAV-pTMEM119-shDNMT1), which specifically targeted microglia and induced a M2-like polarization in vitro and in vivo in doxycycline-treated rTg4510 mice. Intravenous infusion of AAV-pTMEM119-shDNMT1 induced M2-polarization of microglia and attenuated both AD-associated behavior impairment but also NP in the doxycycline-treated rTg4510 mice. Thus, our data suggest that AD-associated NP may be treated through M2-polarization of microglia.
- Published
- 2020
33. Venetoclax and Decitabine for T/Myeloid Mixed-Phenotype Acute Leukemia Not Otherwise Specified (MPAL NOS)
- Author
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Solomon A. Graf, Daniel Y Wu, Robert E. Richard, Nicholas Burwick, Craig O'Brien, Thomas R. Chauncey, Heather Klocke, and Zhao Ming Dong
- Subjects
Oncology ,medicine.medical_specialty ,Myeloid ,Decitabine ,Case Report ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,hemic and lymphatic diseases ,medicine ,Diseases of the blood and blood-forming organs ,Acute leukemia ,business.industry ,Venetoclax ,Not Otherwise Specified ,General Medicine ,medicine.disease ,Leukemia ,medicine.anatomical_structure ,Hypomethylating agent ,chemistry ,030220 oncology & carcinogenesis ,Stem cell ,RC633-647.5 ,business ,030215 immunology ,medicine.drug - Abstract
T/myeloid mixed-phenotype acute leukemia not otherwise specified (MPAL NOS) is an uncommon and aggressive leukemia without well-established treatment guidelines, particularly when relapsed. Venetoclax plus a hypomethylating agent offers a promising option in this situation since studies support its use in both acute myeloid and, albeit with fewer data to date, acute T-cell-lymphoblastic leukemias. We report the successful eradication of T/myeloid MPAL NOS relapsed after allogeneic stem cell transplant with venetoclax plus decitabine. A consolidative allogeneic stem cell transplant from a second donor was subsequently performed, and the patient remained without evidence of disease more than one year later. Further investigation is indicated to evaluate venetoclax combined with hypomethylating agents and/or other therapies for the management of T/myeloid MPAL NOS.
- Published
- 2020
34. Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants
- Author
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Rodriguez-Martinez, Andrea, Zhou, Bin, Sophiea, Marisa K, Bentham, James, Paciorek, Christopher J, Iurilli, Maria LC, Carrillo-Larco, Rodrigo M, Bennett, James E, Di Cesare, Mariachiara, Taddei, Cristina, Bixby, Honor, Stevens, Gretchen A, Riley, Leanne M, Cowan, Melanie J, Savin, Stefan, Danaei, Goodarz, Chirita-Emandi, Adela, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Malekzadeh, Reza, Miranda, J Jaime, Moon, Jin Soo, Popovic, Stevo R, Sorensen, Thorkild IA, Soric, Maroje, Starc, Gregor, Zainuddin, Ahmad A, Gregg, Edward W, Bhutta, Zulfiqar A, Black, Robert, Ezzati, Majid, Abarca-Gomez, Leandra, Abdeen, Ziad A, Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F Abdul, Abu-Rmeileh, Niveen M, Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assuncao, Maria Cecilia F, Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V, Jorgensen, Maja Baeksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R, Baran, Joanna, Barbagallo, Carlo M, Barcelo, Alberto, Barkat, Amina, Barros, Aluisio JD, Barros, Mauro Virgilio Gomes, Basit, Abdul, Bastos, Joao Luiz D, Bata, Iqbal, Batieha, Anwar M, Batista, Rosangela L, Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Bjorkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boeing, Heiner, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Bovet, Pascal, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, de Leon, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C, Canete, Felicia, Capanzana, Mario V, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A, Casanueva, Felipe F, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamukuttan, Snehalatha, Chan, Angelique W, Chan, Queenie, Chaturvedi, Himanshu K, Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Crujeiras, Ana B, Csilla, Semanova, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, D'Arrigo, Graziella, d'Orsi, Eleonora, Dacica, Liliana, Saavedra, Maria Angeles Dal Re, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, 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Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Hoang, Van Minh, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Varona-Perez, Patricia, Vasan, Senthil K, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Villalpando, Salvador, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Volzke, Henry, Voutilainen, Ari, Voutilainen, Sari, Vrijheid, Martine, Vrijkotte, Tanja GM, Wade, Alisha N, Wagner, Aline, Waldhor, Thomas, Walton, Janette, Wambiya, Elvis OA, Bebakar, Wan Mohamad Wan, Mohamud, Wan Nazaimoon Wan, de Souza, Rildo, Junior, Wanderley, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Weber, Adelheid, Wedderkopp, Niels, Weerasekera, Deepa, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Wiecek, Andrzej, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yaseri, Mehdi, Yasuharu, Tabara, Ye, Xingwang, Yiallouros, Panayiotis K, Yoosefi, Moein, Yoshihara, Akihiro, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilova, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zdrojewski, Tomasz, Vrkic, Tajana Zeljkovic, Zeng, Yi, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zocalo, Yanina, Cisneros, Julio Zuniga, Zuziak, Monika, Faculdade de Ciências da Nutrição e Alimentação, Instituto de Saúde Pública da Universidade do Porto, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Environnement, Santé, Sociétés (ESS), Centre National de la Recherche Scientifique (CNRS), European Project: 774548, Reproductive Origins of Adult Health and Disease (ROAHD), Rodriguez-Martinez A, Zhou B, Sophiea MK, Bentham J, Paciorek CJ, Iurilli ML, Carrillo-Larco RM, Bennett JE, Di Cesare M, Taddei C, Bixby H, Stevens GA, Riley LM, Cowan MJ, Savin S, 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Cai H, Cama T, Cameron C, Camolas J, Can G, Cândido APC, Cañete F, Capanzana MV, Capková N, Capuano E, Capuano V, Cardol M, Cardoso VC, Carlsson AC, Carmuega E, Carvalho J, Casajús JA, Casanueva FF, Celikcan E, Censi L, Cervantes-Loaiza M, Cesar JA, Chamukuttan S, Chan AW, Chan Q, Chaturvedi HK, Chaturvedi N, Che Abdul Rahim N, Chen C-J, Chen F, Chen H, Chen S, Chen Z, Cheng C-Y, Cheraghian B, Chetrit A, Chikova-Iscener E, Chiolero A, Chiou S-T, Chirlaque M-D, Cho B, Christensen K, Christofaro DG, Chudek J, Cifkova R, Cilia M, Cinteza E, Claessens F, Clarke J, Clays E, Cohen E, Concin H, Confortin SC, Cooper C, Coppinger TC, Corpeleijn E, Costanzo S, Cottel D, Cowell C, Craig CL, Crampin AC, Crujeiras AB, Csilla S, Cucu AM, Cui L, Cureau FV, D'Arrigo G, d'Orsi E, Dacica L, Dal Re Saavedra MÁ, Dallongeville J, Damasceno A, Damsgaard CT, Dankner R, Dantoft TM, Dasgupta P, Dastgiri S, Dauchet L, Davletov K, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, de Oliveira PD, De Ridder D, De Ridder K, de Rooij SR, De Smedt D, Deepa M, Deev AD, DeGennaro V, Jr, Dehghan A, Delisle H, Delpeuch F, Demarest S, Dennison E, Deren K, Deschamps V, Dhana K, Dhimal M, Di Castelnuovo AF, Dias-da-Costa JS, Díaz-Sánchez ME, Diaz A, Dika Z, Djalalinia S, Djordjic V, Do HT, Dobson AJ, Donati MB, Donfrancesco C, Donoso SP, Döring A, Dorobantu M, Dorosty AR, Doua K, Drygas W, Duan JL, Duante CA, Duboz P, Duda RB, Duleva V, Dulskiene V, Dumith SC, Dushpanova A, Dzerve V, Dziankowska-Zaborszczyk E, Eddie R, Eftekhar E, Egbagbe EE, Eggertsen R, Eghtesad S, Eiben G, Ekelund U, El-Khateeb M, El Ati J, Eldemire-Shearer D, Eliasen M, Elliott P, Engle-Stone R, Enguerran M, Erasmus RT, Erbel R, Erem C, Eriksen L, Eriksson JG, Escobedo-de la Peña J, Eslami S, Esmaeili A, Evans A, Faeh D, Fakhretdinova AA, Fall CH, Faramarzi E, Farjam M, Farrugia Sant'Angelo V, Farzadfar F, Fattahi MR, Fawwad A, Felix-Redondo FJ, Ferguson TS, Fernandes RA, Fernández-Bergés D, Ferrante D, Ferrao T, Ferrari M, Ferrario MM, Ferreccio C, Ferrer E, Ferrieres J, Figueiró TH, Fijalkowska A, Fink G, Fischer K, Föger B, Foo LH, Forsner M, Fouad HM, Francis DK, Franco MDC, Franco OH, Frikke-Schmidt R, Frontera G, Fuchs FD, Fuchs SC, Fujiati II, Fujita Y, Fumihiko M, Furusawa T, Gaciong Z, Gafencu M, Galbarczyk A, Galenkamp H, Galeone D, Galfo M, Galvano F, Gao J, Garcia-de-la-Hera M, García-Solano M, Gareta D, Garnett SP, Gaspoz J-M, Gasull M, Gaya ACA, Gaya AR, Gazzinelli A, Gehring U, Geiger H, Geleijnse JM, Ghanbari A, Ghasemi E, Gheorghe-Fronea O-F, Giampaoli S, Gianfagna F, Gill TK, Giovannelli J, Gironella G, Giwercman A, Gkiouras K, Godos J, Gogen S, Goldsmith RA, Goltzman D, Gómez SF, Gomula A, Goncalves Cordeiro da Silva B, Gonçalves H, Gonzalez-Chica DA, Gonzalez-Gross M, González-Leon M, González-Rivas JP, González-Villalpando C, González-Villalpando M-E, Gonzalez AR, Gottrand F, Graça AP, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou MG, Gregor RD, Grodzicki T, Grøholt EK, 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JM, Ibrahim MM, Ibrahim Wong N, Ikeda N, Ikram MA, Iotova V, Irazola VE, Ishida T, Islam M, Islam SMS, Iwasaki M, Jackson RT, Jacobs JM, Jaddou HY, Jafar T, James K, Jamil KM, Jamrozik K, Janszky I, Janus E, Jarani J, Jarvelin M-R, Jasienska G, Jelakovic A, Jelakovic B, Jennings G, Jha AK, Jiang CQ, Jimenez RO, Jöckel K-H, Joffres M, Johansson M, Jokelainen JJ, Jonas JB, Jørgensen T, Joshi P, Joukar F, Jovic DP, Józwiak JJ, Juolevi A, Jurak G, Jurca Simina I, Juresa V, Kaaks R, Kaducu FO, Kafatos A, Kajantie EO, Kalmatayeva Z, Kalter-Leibovici O, Kameli Y, Kanala KR, Kannan S, Kapantais E, Karki KB, Katibeh M, Katz J, Katzmarzyk PT, Kauhanen J, Kaur P, Kavousi M, Kazakbaeva GM, Keil U, Keinan Boker L, Keinänen-Kiukaanniemi S, Kelishadi R, Kelleher C, Kemper HC, Keramati M, Kerimkulova A, Kersting M, Key T, Khader YS, Khalili D, Khaw K-T, Kheiri B, Kheradmand M, Khosravi A, Khouw IM, Kiechl-Kohlendorfer U, Kiechl S, Killewo J, Kim DW, Kim HC, Kim J, Kindblom JM, Klakk H, Klimek M, Klimont J, Klumbiene J, Knoflach M, Koirala B, Kolle E, Kolsteren P, König J, Korpelainen R, Korrovits P, Korzycka M, Kos J, Koskinen S, Kouda K, Kovacs VA, Kowlessur S, Koziel S, Kratzer W, Kriemler S, Kristensen PL, Krokstad S, Kromhout D, Krtalic B, Kruger HS, Kubinova R, Kuciene R, Kujala UM, Kujundzic E, Kulaga Z, Kumar RK, Kunešová M, Kurjata P, Kusuma YS, Kuulasmaa K, Kyobutungi C, La QN, Laamiri FZ, Laatikainen T, Lachat C, Laid Y, Lam TH, Lambrinou C-P, Landais E, Lanska V, Lappas G, Larijani B, Latt TS, Lauria L, Lazo-Porras M, Le Nguyen Bao K, Le Port A, Le TD, Lee J, Lee J, Lee PH, Lehmann N, Lehtimäki T, Lemogoum D, Levitt NS, Li Y, Liivak M, Lilly CL, Lim W-Y, Lima-Costa MF, Lin H-H, Lin X, Lin Y-T, Lind L, Linneberg A, Lissner L, Litwin M, Liu J, Liu L, Lo W-C, Loit H-M, Long KQ, Lopes L, Lopes O, Lopez-Garcia E, Lopez T, Lotufo PA, Lozano JE, Lukrafka JL, Luksiene D, Lundqvist A, Lundqvist R, Lunet N, Lunogelo C, Lustigová M, Luszczki E, Ma G, Ma J, Ma X, Machado-Coelho GL, Machado-Rodrigues AM, Machi S, Macieira LM, Madar AA, Maggi S, Magliano DJ, Magnacca S, Magriplis E, Mahasampath G, Maire B, Majer M, Makdisse M, Mäki P, Malekzadeh F, Malhotra R, Mallikharjuna Rao K, Malyutina SK, Maniego LV, Manios Y, Mann JI, Mansour-Ghanaei F, Manzato E, Margozzini P, Markaki A, Markey O, Markidou Ioannidou E, Marques-Vidal P, Marques LP, Marrugat J, Martin-Prevel Y, Martin R, Martorell R, Martos E, Marventano S, Mascarenhas LP, Masoodi SR, Mathiesen EB, Mathur P, Matijasevich A, Matsha TE, Mavrogianni C, Mazur A, Mbanya JCN, McFarlane SR, McGarvey ST, McKee M, McLachlan S, McLean RM, McLean SB, McNulty BA, Mediene-Benchekor S, Medzioniene J, Mehdipour P, Mehlig K, Mehrparvar AH, Meirhaeghe A, Meisfjord J, Meisinger C, Menezes AMB, Menon GR, Mensink GB, Menzano MT, Mereke A, Meshram II, Metspalu A, Mi J, Michaelsen KF, Michels N, Mikkel K, Milkowska K, Miller JC, Minderico CS, Mini GK, Miquel JF, Mirjalili MR, Mirkopoulou D, Mirrakhimov E, Mišigoj-Durakovic M, Mistretta A, Mocanu V, Modesti PA, Moghaddam SS, Mohajer B, Mohamed MK, Mohamed SF, Mohammad K, Mohammadi Z, Mohammadifard N, Mohammadpourhodki R, Mohan V, Mohanna S, Mohd Yusoff MF, Mohebbi I, Mohebi F, Moitry M, Molbo D, Møllehave LT, Møller NC, Molnár D, Momenan A, Mondo CK, Monroy-Valle M, Monterrubio-Flores E, Monyeki KDK, Moosazadeh M, Moreira LB, Morejon A, Moreno LA, Morgan K, Morin SN, Mortensen EL, Moschonis G, Mossakowska M, Mostafa A, Mota-Pinto A, Mota J, Motlagh ME, Motta J, Moura-dos-Santos MA, Mridha MK, Msyamboza KP, Mu TT, Muc M, Mugoša B, Muiesan ML, Mukhtorova P, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh EM, Musa KI, Music Milanovic S, Musil V, Mustafa N, Nabipour I, Naderimagham S, Nagel G, Naidu BM, Najafi F, Nakamura H, Námešná J, Nang EEK, Nangia VB, Nankap M, Narake S, Nardone P, Nauck M, Neal WA, Nejatizadeh A, Nelis K, Nelis L, Nenko I, Neovius M, Nervi F, Nguyen CT, Nguyen D, Nguyen QN, Nieto-Martínez RE, Nikitin YP, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa OA, Nogueira H, Norat T, Nordendahl M, Nordestgaard BG, Noto D, Nowak-Szczepanska N, Nsour MA, Nuhoglu I, Nurk E, O'Neill TW, O'Reilly D, Obreja G, Ochimana C, Ochoa-Avilés AM, Oda E, Oh K, Ohara K, Ohlsson C, Ohtsuka R, Olafsson Ö, Olinto MTA, Oliveira IO, Omar MA, Onat A, Ong SK, Ono LM, Ordunez P, Ornelas R, Ortiz AP, Ortiz PJ, Osler M, Osmond C, Ostojic SM, Ostovar A, Otero JA, Overvad K, Owusu-Dabo E, Paccaud FM, Padez C, Pagkalos I, Pahomova E, Paiva KMD, Pajak A, Palli D, Palloni A, Palmieri L, Pan W-H, Panda-Jonas S, Pandey A, Panza F, Papandreou D, Park S-W, Park S, Parnell WR, Parsaeian M, Pascanu IM, Pasquet P, Patel ND, Pednekar MS, Peer N, Peixoto SV, Peltonen M, Pereira AC, Peres MA, Pérez-Farinós N, Pérez CM, Peterkova V, Peters A, Petersmann A, Petkeviciene J, Petrauskiene A, Pettenuzzo E, Peykari N, Pham ST, Pichardo RN, Pierannunzio D, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Pizarro AN, Plans-Rubió P, Poh BK, Pohlabeln H, 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Piwonska A., Pizarro A.N., Plans-Rubio P., Poh B.K., Pohlabeln H., Pop R.M., Porta M., Posch G., Poudyal A., Poulimeneas D., Pouraram H., Pourfarzi F., Pourshams A., Poustchi H., Pradeepa R., Price A.J., Price J.F., Providencia R., Puder J.J., Pudule I., Puhakka S.E., Puiu M., Punab M., Qasrawi R.F., Qorbani M., Quoc Bao T., Radic I., Radisauskas R., Rahimikazerooni S., Rahman M., Raitakari O., Raj M., Rakhimova E., Rakhmatulloev S., Rakovac I., Ramachandra Rao S., Ramachandran A., Ramke J., Ramos E., Ramos R., Rampal L., Rampal S., Rarra V., Rascon-Pacheco R.A., Rasmussen M., Rech C.R., Redon J., Reganit P.F.M., Regecova V., Revilla L., Rezaianzadeh A., Ribas-Barba L., Ribeiro R., Riboli E., Richter A., Rigo F., Rinaldo N., Rinke de Wit T.F., Rito A., Ritti-Dias R.M., Rivera J.A., Robitaille C., Roccaldo R., Rodrigues D., Rodriguez-Artalejo F., Rodriguez-Perez M.D.C., Rodriguez-Villamizar L.A., Roggenbuck U., Rojas-Martinez R., Rojroongwasinkul N., Romaguera D., Romeo E.L., Rosario R.V., Rosengren A., Rouse I., Roy J.G., Rubinstein A., Ruhli F.J., Ruidavets J.-B., Ruiz-Betancourt B.S., Ruiz Moreno E., Rusakova I.A., Russell Jonsson K., Russo P., Rust P., Rutkowski M., Sabanayagam C., Sacchini E., Sachdev H.S., Sadjadi A., Safarpour A.R., Safi S., Safiri S., Saidi O., Saki N., Salanave B., Salazar Martinez E., Salmeron D., Salomaa V., Salonen J.T., Salvetti M., Samoutian M., Sanchez-Abanto J., Sandjaja, Sans S., Santa Marina L., Santos D.A., Santos I.S., Santos L.C., Santos M.P., Santos O., Santos R., Santos Sanz S., Saramies J.L., Sardinha L.B., Sarrafzadegan N., Sathish T., Saum K.-U., Savva S., Savy M., Sawada N., Sbaraini M., Scazufca M., Schaan B.D., Schaffrath Rosario A., Schargrodsky H., Schienkiewitz A., Schindler K., Schipf S., Schmidt C.O., Schmidt I.M., Schnohr P., Schottker B., Schramm S., Schroder H., Schultsz C., Schutte A.E., Sebert S., Sein A.A., Selamat R., Sember V., Sen A., Senbanjo I.O., Sepanlou S.G., Sequera V., Serra-Majem L., Servais J., Sevcikova L., Shalnova S.A., Shamah-Levy T., Shamshirgaran M., Shanthirani C.S., Sharafkhah M., Sharma S.K., Shaw J.E., Shayanrad A., Shayesteh A.A., Shengelia L., Shi Z., Shibuya K., Shimizu-Furusawa H., Shin D.W., Shin Y., Shirani M., Shiri R., Shrestha N., Si-Ramlee K., Siani A., Siantar R., Sibai A.M., Silva A.M., Silva D.A.S., Simon M., Simons J., Simons L.A., Sjoberg A., Sjostrom M., Skodje G., Slowikowska-Hilczer J., Slusarczyk P., Smeeth L., So H.-K., Soares F.C., Sobek G., Sobngwi E., Sodemann M., Soderberg S., Soekatri M.Y., Soemantri A., Sofat R., Solfrizzi V., Somi M.H., Sonestedt E., Song Y., Sorgjerd E.P., Sossa Jerome C., Soto-Rojas V.E., Soumare A., Sovic S., Sparboe-Nilsen B., Sparrenberger K., Spinelli A., Spiroski I., Staessen J.A., Stamm H., Stathopoulou M.G., Staub K., Stavreski B., Steene-Johannessen J., Stehle P., Stein A.D., Stergiou G.S., Stessman J., Stevanovic R., Stieber J., Stockl D., Stocks T., Stokwiszewski J., Stoyanova E., Stratton G., Stronks K., Strufaldi M.W., Sturua L., Suarez-Medina R., Suka M., Sun C.-A., Sundstrom J., Sung Y.-T., Sunyer J., Suriyawongpaisal P., Swinburn B.A., Sy R.G., Syddall H.E., Sylva R.C., Szklo M., Szponar L., Tai E.S., Tammesoo M.-L., Tamosiunas A., Tan E.J., Tang X., Tanser F., Tao Y., Tarawneh M.R., Tarp J., Tarqui-Mamani C.B., Taxova Braunerova R., Taylor A., Taylor J., Tchibindat F., Tebar W.R., Tell G.S., Tello T., Thankappan K.R., Theobald H., Theodoridis X., Thijs L., Thomas N., Thuesen B.H., Ticha L., Timmermans E.J., Tjonneland A., Tolonen H.K., Tolstrup J.S., Topbas M., Topor-Madry R., Torheim L.E., Tormo M.J., Tornaritis M.J., Torrent M., Torres-Collado L., Toselli S., Traissac P., Tran T.T.-H., Trichopoulos D., Trichopoulou A., Trinh O.T., Trivedi A., Tshepo L., Tsigga M., Tsugane S., Tuliakova A.M., Tulloch-Reid M.K., Tullu F., Tuomainen T.-P., Tuomilehto J., Turley M.L., Tynelius P., Tzotzas T., Tzourio C., Ueda P., Ugel E., Ukoli F.A., Ulmer H., Unal B., Usupova Z., Uusitalo H.M., Uysal N., Vaitkeviciute J., Valdivia G., Vale S., Valvi D., van Dam R.M., Van der Heyden J., van der Schouw Y.T., Van Herck K., Van Minh H., van Valkengoed I.G., Vanderschueren D., Vanuzzo D., Varbo A., Varela-Moreiras G., Varona-Perez P., Vasan S.K., Vega T., Veidebaum T., Velasquez-Melendez G., Velika B., Veronesi G., Verschuren W.M., Victora C.G., Viegi G., Viet L., Villalpando S., Vineis P., Vioque J., Virtanen J.K., Visser M., Visvikis-Siest S., Viswanathan B., Vladulescu M., Vlasoff T., Vocanec D., Volzke H., Voutilainen A., Voutilainen S., Vrijheid M., Vrijkotte T.G., Wade A.N., Wagner A., Waldhor T., Walton J., Wambiya E.O., Wan Bebakar W.M., Wan Mohamud W.N., Wanderley Junior R.D.S., Wang M.-D., Wang N., Wang Q., Wang X., Wang Y.X., Wang Y.-W., Wannamethee S.G., Wareham N., Weber A., Wedderkopp N., Weerasekera D., Weghuber D., Wei W., Weres A., Werner B., Whincup P.H., Widhalm K., Widyahening I.S., Wiecek A., Wilks R.J., Willeit J., Willeit P., Williams J., Wilsgaard T., Wojtyniak B., Wong-McClure R.A., Wong A., Wong J.E., Wong T.Y., Woo J., Woodward M., Wu F.C., Wu J., Wu L.J., Wu S., Xu H., Xu L., Yaacob N.A., Yamborisut U., Yan W., Yang L., Yang X., Yang Y., Yardim N., Yaseri M., Yasuharu T., Ye X., Yiallouros P.K., Yoosefi M., Yoshihara A., You Q.S., You S.-L., Younger-Coleman N.O., Yusof S.M., Yusoff A.F., Zaccagni L., Zafiropulos V., Zakavi S.R., Zamani F., Zambon S., Zampelas A., Zamrazilova H., Zapata M.E., Zargar A.H., Zaw K.K., Zdrojewski T., Zeljkovic Vrkic T., Zeng Y., Zhang L., Zhang Z.-Y., Zhao D., Zhao M.-H., Zhao W., Zhen S., Zheng W., Zheng Y., Zholdin B., Zhou M., Zhu D., Zocalo Y., Zuniga Cisneros J., Zuziak M., and Ezzati M.
- Subjects
Male ,body-mass index ,ADULTHOOD ,Adolescents ,pituuskasvu ,Pediatrics ,Body Mass Index ,0302 clinical medicine ,Child Development ,nuoret ,Public health surveillance ,Medicine ,Health Status Indicators ,10. No inequality ,Child ,11 Medical and Health Sciences ,Body mass index ,ComputingMilieux_MISCELLANEOUS ,education.field_of_study ,VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 ,General Medicine ,Body mass indexes ,kansainvälinen vertailu ,3. Good health ,Geography ,Health ,030220 oncology & carcinogenesis ,Child, Preschool ,Medical and Health sciences ,purl.org/becyt/ford/3 [https] ,medicine.medical_specialty ,School-aged adolescents ,Socio-culturale ,lapset (ikäryhmät) ,Nursing ,territories ,ravinto ,purl.org/becyt/ford/3.3 [https] ,03 medical and health sciences ,School Children ,SDG 3 - Good Health and Well-being ,SYSTEMATIC ANALYSIS ,Humans ,school-aged children and adolescents ,Montenegro ,education ,Science & Technology ,Omvårdnad ,Health sciences, Medical and Health sciences ,Ciências médicas e da saúde ,Bayes Theorem ,Anthropometry ,Adolescent Development ,medicine.disease ,TRENDS ,Height and Body-mass Index ,Faculdade de Ciências Sociais ,UNDERNUTRITION ,Height index trajectories ,Height, body mass index, children , epidemiology ,risk factors, growth ,Stature ,Demography ,Settore MED/09 - Medicina Interna ,Internationality ,[SDV]Life Sciences [q-bio] ,030204 cardiovascular system & hematology ,Body-mass index trajectories ,Epidemiology ,Medicine and Health Sciences ,risk factors ,countries ,EPIDEMIOLOGY ,height ,children ,adolescents ,BMI ,030212 general & internal medicine ,painoindeksi ,Child development ,2. Zero hunger ,Medicine(all) ,School age child ,obestity children cardiovascular ,Population Health ,1. No poverty ,Pediatrik ,Public Health, Global Health, Social Medicine and Epidemiology ,3142 Public health care science, environmental and occupational health ,Pooled analysis ,NUTRITION ,Female ,medicine.symptom ,pooled analysis ,Life Sciences & Biomedicine ,terveys ,height, BMI, nutrition, health, children, adolescents ,Adolescent ,growth ,Population ,body-mass ,Population based ,Body-mass index ,Young Adult ,Medicine, General & Internal ,Meta-Analysis as Topic ,General & Internal Medicine ,parasitic diseases ,Weight gain ,School-aged childrens ,Age trajectories ,business.industry ,Height ,Weight ,Body Height ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Malnutrition ,ONSET ,Ciências da Saúde, Ciências médicas e da saúde ,School-aged children ,VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 ,business ,terveysriskit ,Estilos de Vida e Impacto na Saúde - Abstract
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents., METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence., FINDINGS: We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls., INTERPRETATION: The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks., Wellcome Trust, AstraZeneca Young Health Programme, EU., peer-reviewed
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- 2020
35. Comment on 'effect of dietary vitamins C and E on the risk of Parkinson's disease: A meta-analysis'
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Zhao-Ming Ge, Chong-Chong Zhao, and Hong-Bin Cai
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Oncology ,medicine.medical_specialty ,Nutrition and Dietetics ,Parkinson's disease ,business.industry ,Parkinson Disease ,Ascorbic Acid ,Vitamins ,Critical Care and Intensive Care Medicine ,medicine.disease ,Diet ,Internal medicine ,Meta-analysis ,medicine ,Humans ,Vitamin E ,business - Published
- 2022
36. The change of cervical sagittal alignment after surgery for adolescent idiopathic scoliosis
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Jianting Chen, Si-Yuan Zhu, Shi-Gan Luo, and Zhao-Ming Zhong
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Male ,Pelvic tilt ,medicine.medical_specialty ,Adolescent ,Radiography ,Posture ,Idiopathic scoliosis ,Thoracic kyphosis ,Thoracic Vertebrae ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Sagittal alignment ,Kyphosis ,Postoperative Period ,Child ,Cervical kyphosis ,030222 orthopedics ,Lumbar Vertebrae ,Cobb angle ,business.industry ,General Medicine ,Sagittal plane ,Surgery ,Spinal Fusion ,medicine.anatomical_structure ,Scoliosis ,Cervical Vertebrae ,Lordosis ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
The postoperative change in cervical sagittal alignment has an impact on health-related quality of life in adolescent idiopathic scoliosis (AIS) patients who have undergone deformity correction. However, the effect of deformity correction on sagittal cervical profile is still controversial in the literatures. The objective of this study was to investigate the postoperative change in the cervical sagittal alignment of patients with AIS.A total of 46 AIS patients treated by posterior instrumentation and fusion with pedicle screw constructs were included in the study. Radiographs were collected preoperatively, immediate postoperatively and at the final follow-up. The C2-C7 Cobb angle and C2-C7 sagittal vertical axis (cSVA) were used to assess the cervical sagittal alignment. Spinopelvic alignment parameters, such as thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), and sagittal vertical axis (SVA), were also measured. The correlations between the cervical sagittal parameters and spinopelvic parameters were analyzed.The incidence of cervical kyphosis was 67.4% preoperatively but increased to 87% postoperatively and 69.5% at the final follow-up. The C2-C7 Cobb angle significantly increased from pre-operation (-1.5° ± 15°) to post-operation (-5.4° ± 7.3°; P 0.05) and spontaneously decreased to -2.9° ± 10.5° at the final follow up. The cSVA was 18.1 ± 13 mm preoperatively, 17 ± 12.3 mm after surgery and 18.5 ± 9.5 mm at the last follow-up, but the change was not statistically significant (P 0.05). TK decreased significantly from pre-operation (17.7° ± 14.4°) to post-operation (14.2° ± 7.6°) and spontaneously improved to 16.9° ± 8.2° at the final follow-up. TK showed a significant correlation with the C2-C7 Cobb angle, but not with cSVA, in the preoperative (r = 0.709, P 0.01), postoperative (r = 0.472, P 0.01), and last follow-up measurements(r = 0.505, P 0.01). Compared with patients with preoperative thoracic hypokyphosis or hyperkyphosis, patients with a normal thoracic spine had more significant postoperative changes in the C2-C7 Cobb angle and TK.Cervical sagittal alignment after deformity correction is altered in AIS patients. An increase in cervical kyphosis after surgery is correlated with a loss of thoracic kyphosis. The change in the cervical sagittal profile may be a compensatory mechanism in response to an abnormal thoracic sagittal profile.
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- 2018
37. Intracapillary monoclonal deposits disease due to B-cell non-Hodgkin lymphoma: A case report and review of the literature
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Sarah F. Sanghavi, Ryan C. Lynch, Zhao Ming Dong, and Roberto F. Nicosia
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Pathology ,medicine.medical_specialty ,business.industry ,Crescentic glomerulonephritis ,Monoclonal igm ,Disease ,medicine.disease ,Glomerular capillary ,Monoclonal ,Membranoproliferative glomerulonephritis ,medicine ,B-Cell Non-Hodgkin Lymphoma ,Kidney disorder ,business - Abstract
Intracapillary monoclonal deposits disease is a rare kidney disorder defined by the presence of intracapillary monoclonal IgM deposits that completely obstruct glomerular capillary lumina. It is typically associated with Waldenstrom macroglobulinemia and significant levels of circulating monoclonal IgM. We describe a patient that presented with nephrotic range proteinuria, rapidly rising serum creatinine, and low levels of biclonal IgM. Kidney biopsy showed intracapillary monoclonal deposits disease with a membranoproliferative pattern and focal crescent formation. Subsequent bone marrow biopsy revealed marginal zone lymphoma. Despite treatment, the patient rapidly progressed to end-stage renal disease. Patients with indolent lymphomas and low levels of circulating clonal IgM may present with aggressive renal disease due to IgM deposition.
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- 2018
38. Fiber Coupling of Multi-single Emitters Diode Lasers Based on Curved Surface Spatial Combination
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赵明 Zhao Ming, 刘友强 Liu You-qiang, 邱运涛 Qiu Yun-tao, 李景 Li Jing, 许商瑞 Xu Shang-rui, 谢文君 Xie Wen-jun, 曹银花 Cao Yin-hua, 张晓宁 Zhang Xiao-ning, and 王智勇 Wang Zhiyong
- Subjects
Surface (mathematics) ,Radiation ,Materials science ,business.industry ,law ,Optoelectronics ,Condensed Matter Physics ,business ,Laser ,Fiber coupling ,Electronic, Optical and Magnetic Materials ,law.invention ,Diode - Published
- 2018
39. Research and Design of High Power Concentrator Module System
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王聪聪 Wang Cong-cong, 张晓宁 Zhang Xiao-ning, 刘友强 Liu You-qiang, 郭丽敏 Guo Limin, 曹银花 Cao Yin-hua, 张红梅 Zhang Hong-mei, 王智勇 Wang Zhiyong, 赵明 Zhao Ming, and 黄瑞 Huang Rui
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Radiation ,Materials science ,business.industry ,Electrical engineering ,Condensed Matter Physics ,business ,Concentrator ,Electronic, Optical and Magnetic Materials ,Power (physics) - Published
- 2018
40. Joint frame synchronization and frequency offset estimationin OFDM systems
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Zhang, Zhongshan, Long, Keping, Zhao, Ming, and Liu, Yuanan
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Algorithms -- Research ,Algorithms -- Technology application ,Algorithm ,Technology application ,Business ,Electronics ,Mass communications - Abstract
A new joint frame synchronization and carrier frequency offset estimation scheme in orthogonal frequency division multiplexing (OFDM) systems is proposed in this paper, where both frame synchronization and carrier frequency offset estimation can be performed by using only ONE training symbol. Frame synchronization and carrier frequency offset acquisition are performed simultaneously in the proposed scheme. Reliable frame synchronization is obtained in the proposed scheme even in low SNR. The maximum carrier frequency offset acquisition range of the proposed scheme can be up to one half of the total signal bandwidth. The same training symbol can also be utilized to carrier frequency offset Fine Adjustment, which estimates the remaining carrier frequency offset after acquisition with higher accuracy. The performance comparison of the proposed Fine Adjustment algorithm and Schmidl's algorithm by using computer simulation illustrates and verify the superior performance of the proposed algorithm with regard to estimation accuracy. Index Terms--Frequency offset estimation, multipath channel, OFDM, synchronization.
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- 2005
41. Chronic active Epstein-Barr virus infection of T cell type presenting with hemophagocytic lymphohistiocytosis in a Caucasian adult
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Nicholas Burwick, Debbie Jiang, and Zhao Ming Dong
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medicine.medical_specialty ,Hemophagocytic lymphohistiocytosis ,Hematology ,business.industry ,T cell ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Internal medicine ,Chronic Active Epstein-Barr Virus ,Immunology ,medicine ,business - Published
- 2021
42. Preparation and properties of self-pulverizing calcium sulfoaluminate cement
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Zhang, Xiong, Zhao, Ming, and Zhang, Yongjuan
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Calcium -- Chemical properties -- Research ,Raw materials -- Usage ,Cement -- Analysis -- Properties -- Research ,Business ,Construction and materials industries - Abstract
ABSTRACT The transition of β-[C.sub.2]S to γ-[C.sub.2]S can be used to pulverize cement clinkers for saving grinding energy because the volume expansion occurs in this process. Self-pulverizing calcium sulfoaluminate cement [...]
- Published
- 2012
- Full Text
- View/download PDF
43. How to Fill the Cavity after Curettage of Giant Cell Tumors around the Knee? A Multicenter Analysis
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Kai Zheng, Xiu-Chun Yu, Yong-Cheng Hu, Zhen Wang, Su-Jia Wu, Zhao-Ming Ye, and Giant Cell Tumor Group of China (GTOC)
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Adult ,Male ,medicine.medical_specialty ,Knee Joint ,medicine.medical_treatment ,lcsh:Medicine ,Bone Neoplasms ,Bone grafting ,Curettage ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Knee ,Giant Cell Tumors ,Tumor location ,Bone Grafting ,Cementation ,Retrospective Studies ,Giant Cell Tumor of Bone ,030222 orthopedics ,Surgical complication ,business.industry ,lcsh:R ,Retrospective cohort study ,General Medicine ,Giant Cell Tumor ,Middle Aged ,Surgery ,surgical procedures, operative ,Filling materials ,030220 oncology & carcinogenesis ,Radiological weapon ,Original Article ,Female ,business - Abstract
Background: Intralesional excision with curettage is the standard method of giant cell tumor (GCT) treatment, but the ideal filling material after curettage remains controversial. The purpose of this study was to compare the oncological and functional outcomes which underwent cementation or bone grafting after GCT curettage around the knee. Methods: We reported 136 cases with GCTs in distal femur or proximal tibia who accepted curettage from five clinical centers during the last 15 years. All patients were divided into two groups according to filling materials. Recurrence-free survival proportions were used to evaluate oncological outcomes while the Musculoskeletal Tumor Society (MSTS) 93 functional score was used to evaluate functional outcomes. Other parameters including surgical complication, general condition, and radiological classification had been analyzed. The valid statisitical data was analyzed using SPSS 13.0 software. Results: After GCT curettage, 86 patients (63.2%) accepted bone grafting while 50 patients (36.8%) accepted cementation. There was no statistical difference in age, gender, tumor location, radiological classification, fixation, follow-up time, and MSTS 93 functional score between cementation group and bone grafting group. The recurrence-free survival proportions showed that the recurrence rate in bone grafting group was higher than it in cementation group (P = 0.034). Surgical complication was lower in cementation group than that in bone grafting group but without statistically significant difference (P = 0.141). Conclusions: Parameters including patients’ age, gender, tumor location, and radiological classification did not affect surgeons’ treatments in cavity filling after GCT curettage. Cementation should be recommended because of easy usage, the similar postoperative knee function with bone grafting, and the better local tumor control than bone grafting. Key words: Bone Grafting; Cementation; Giant Cell Tumor; Knee
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- 2017
44. Research on New Type Disc Lock Scaffold Safety Monitoring System
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Yang Guowei, Chen Rui, Zhao Ming, and Chen Junrong
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Engineering ,Scaffold ,Record locking ,business.industry ,Formwork ,Support system ,business ,Construction engineering ,Bridge engineering ,Safety monitoring - Abstract
With the continuous development of building and bridge engineering, building formwork system in our country has experienced the development from wooden formwork to steel formwork and then a new type of formwork system at the present stage. As an important part of formwork system, its support system has also experienced the development from wooden bar or steel pipe to formwork made of steel or wooden beams and then scaffold support system. However, some problems in the use of traditional scaffolding system promote the emergence of a new type of disc lock scaffolding support system, which makes up for the shortcomings in the performance of traditional scaffolding. In this paper, a safety monitoring system for the new type of disc lock scaffolding is studied and applied to practice Through the monitoring of stress, incline，settlement and displacement of the scaffold，its safety can be ensured. Based on the monitoring data，some conclusions have be drawn and the direction of the research can be clearer.
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- 2019
45. Discussion of Power System Operation Risk Control Technology in Natural Disasters
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Yu Chen, Jun Guo, Zhao Ming, Chang Kang, Wang Haohao, and Xu Taishan
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Warning system ,Emergency management ,business.industry ,Computer science ,Blackout ,Fault (power engineering) ,Electric power system ,Electronic stability control ,Risk analysis (engineering) ,medicine ,medicine.symptom ,Natural disaster ,Risk assessment ,business - Abstract
It has become a common consensus that the blackout defense framework has been extended to the early warning of natural disasters. Due to the spatial and temporal distribution characteristics of natural disasters’ evolution, and fault uncertainty induced by natural disasters, it is urgent to extend the safety and stability analysis of power system based on deterministic criterion to the operation risk assessment, to extend traditional safety and stability control based on deterministic scenarios listed in three-defense-lines to risk control. In this paper, several key technologies in the field of disaster prevention, namely fault probability assessment, contingency set generation and screening, operation risk assessment and risk control decision-making, are reviewed firstly. Secondly, the risk control framework which is compatible with traditional three-defense-lines and suitable of natural disasters characteristics is discussed. Then the improved method of improving the mentioned key technologies is proposed under the risk control framework.
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- 2019
46. Elevated serum macrophage migration inhibitory factor levels correlate with benign paroxysmal positional vertigo and recurrence events
- Author
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Lei Duan, Hong-Bin Cai, Zhao-Ming Ge, Zi-Chao Li, Chong-Chong Zhao, and Ting Tian
- Subjects
Adult ,Male ,medicine.medical_specialty ,Supine position ,Benign paroxysmal positional vertigo ,recurrence ,Biophysics ,Biochemistry ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Risk Factors ,Vertigo ,Internal medicine ,medicine ,otorhinolaryngologic diseases ,Humans ,Benign Paroxysmal Positional Vertigo ,Prospective Studies ,030223 otorhinolaryngology ,Molecular Biology ,Macrophage Migration-Inhibitory Factors ,Research Articles ,biology ,business.industry ,Cell Biology ,Odds ratio ,inflammatory response ,Middle Aged ,biology.organism_classification ,medicine.disease ,Confidence interval ,Intramolecular Oxidoreductases ,Quartile ,macrophage migration inhibitory factor ,Macrophage migration inhibitory factor ,Female ,sense organs ,business ,030217 neurology & neurosurgery ,Research Article ,Follow-Up Studies - Abstract
Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events. Methods: In the present study, 154 patients with BPPV, and 100 age-and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio-vestibular test battery including the Dix–Hallpike maneuver and supine roll test. In the BPPV group, measurements of MIF levels were repeated 1 month after the vertigo attack. The patients were also divided into the recurrence group and the nonrecurrence group in the 1-year follow-up. Results: The serum levels of MIF in patients with BPPV were higher than in those controls (13.9[interquartile range {IQR}, 8.9–18.4] ng/ml vs. 9.8[7.8–11.8]; P Conclusions: Elevated MIF is positively correlated with BPPV risk and BPPV recurrence events, requiring further efforts to clarify the exact mechanism.
- Published
- 2019
47. Towards Automatic Identification of Chinese Collocation Errors
- Author
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Zhao-Ming Gao
- Subjects
Identification (information) ,Collocation ,Computer science ,business.industry ,Pattern recognition ,Artificial intelligence ,business - Published
- 2019
48. Surgical outcomes of cervical myelopathy due to ossification of posterior longitudinal ligament: Anterior decompression and fusion versus posterior laminoplasty
- Author
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Jianting Chen, Jing-Shen Zhuang, Zhao-Ming Zhong, Chen Tu, Yu-Sheng Huang, and Ping Xu
- Subjects
musculoskeletal diseases ,Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Operative Time ,macromolecular substances ,Ossification of Posterior Longitudinal Ligament ,Spinal Cord Diseases ,Laminoplasty ,03 medical and health sciences ,Myelopathy ,0302 clinical medicine ,Recovery rate ,lcsh:Orthopedic surgery ,medicine ,Posterior longitudinal ligament ,Humans ,Aged ,Retrospective Studies ,030222 orthopedics ,Ossification ,business.industry ,Anterior decompression ,030229 sport sciences ,Middle Aged ,medicine.disease ,Decompression, Surgical ,Surgery ,lcsh:RD701-811 ,Spinal Fusion ,Treatment Outcome ,Cervical Vertebrae ,Female ,medicine.symptom ,business - Abstract
Background: The purpose of this study was to compare the surgical outcomes of anterior decompression and fusion (ADF) with that of posterior laminoplasty (LAMP) for cervical myelopathy caused by ossification of posterior longitudinal ligament (OPLL). Methods: We retrospectively assessed the medical records of patients who underwent surgery for cervical myelopathy owing to OPLL between 2007 and 2016 at our institution. Fifty patients were included in this study, including 17 patients in ADF group and 33 patients in LAMP group. Surgical outcomes were assessed under the Japanese Orthopaedic Association (JOA) score. The radiologic and clinical data were compared between two groups. Results: There was no significant difference in age, follow-up time, operation time, blood loss, length of stay, preoperative JOA score, occupying ratio of OPLL, diameter of spinal canal, preoperative and final follow-up C2-C7 Cobb angles, and the change of C2-C7 Cobb angle before and after operation between ADF and LAMP groups. The final follow-up JOA score and the neurological recovery rate were significantly higher in ADF group than in LAMP group, particularly in patients with segmental-type OPLL. Cerebrospinal fluid leakage is a major complication after ADF, C5 paralysis, and axial pain frequently results from LAMP. Conclusion: Compared with LAMP, ADF shows better improvement of neurological function in patients with cervical myelopathy due to OPLL, especially in patients with segmental-type cervical OPLL.
- Published
- 2019
49. Theoretical and experimental research on Ce:YAG crystals for use in blue laser diode illumination
- Author
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Liu Youqiang, zhao ming, Congcong Wang, and Zhiyong Wang
- Subjects
Blue laser ,Materials science ,business.industry ,Optoelectronics ,business ,Experimental research ,Diode - Published
- 2019
50. Platelet-secreted CCL3 and its receptor CCR5 promote invasive and migratory abilities of anaplastic thyroid carcinoma cells via MMP-1
- Author
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Ru Jia Qin, Xiao Qi, Mu Sheng Zeng, Jin Liang, Chuan Zheng Sun, Rui Cheng, Wei Wang, Xiao Feng Zhu, Hong Ying Chu, and Zhao Ming Zhong
- Subjects
0301 basic medicine ,Blood Platelets ,Chemokine ,Receptors, CCR5 ,CCL3 ,Matrix metalloproteinase ,Thyroid Carcinoma, Anaplastic ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Cell Movement ,Cell Line, Tumor ,Medicine ,Humans ,Platelet ,Thyroid Neoplasms ,Receptor ,Gene ,Chemokine CCL3 ,biology ,business.industry ,NF-kappa B ,Cell Biology ,medicine.disease ,Platelet Activation ,030104 developmental biology ,HEK293 Cells ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Matrix Metalloproteinase 1 ,business - Abstract
Platelet counts have been reported to be closely related to distant metastasis of many malignant tumors. Our previous study showed that elevated peripheral blood platelet counts may be an adverse prognostic factor of anaplastic thyroid carcinoma (ATC) patients, indicating that platelets may promote ATC progression. In the present study, we aimed to identify the role of platelets in ATC cell invasion and migration and to explore the underlying mechanisms. We found that platelets can promote the invasive and migratory of ATC cells, which may be related to the interaction between activated platelet-secreted chemokine (C-C motif) ligand 3 (CCL3) and its receptor CCR5. The interaction was shown to induce the upregulation of matrix metalloproteinase (MMP)-1 via NF-κB pathway. These findings could provide a new idea for the research of targeted platelets to inhibit tumor metastasis.
- Published
- 2019
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