1. Sustained serological and complete responses in HBeAg-positive patients treated with Peginterferon alfa-2b: a 6-year long-term follow-up of a multicenter, randomized, controlled trial in China
- Author
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Yuming Wang, Jian Lu, Jue Wang, Wenxiang Huang, Jifang Sheng, Zhiliang Gao, Jian Sun, Qin Ning, Chen Pan, Huiguo Ding, Chuanzhen Sun, Guofeng Chen, Hong Tang, Qing Xie, Jinlin Hou, Shijun Chen, Guiqiang Wang, Jiming Zhang, Mobin Wan, Lai Wei, Da-Zhi Zhang, Dongliang Yang, Qixin Wang, and Yuxiu Yang
- Subjects
Adult ,Male ,Sustained combined clinical response ,China ,medicine.medical_specialty ,Sustained serological response ,Sustained Virologic Response ,Interferon alpha-2 ,Antiviral Agents ,Gastroenterology ,Chronic hepatitis B ,Polyethylene Glycols ,law.invention ,Serology ,Young Adult ,03 medical and health sciences ,Hepatitis B, Chronic ,0302 clinical medicine ,Randomized controlled trial ,Pegylated interferon ,law ,Internal medicine ,medicine ,Humans ,Hepatitis B e Antigens ,Dosing ,Seroconversion ,lcsh:RC799-869 ,Long-term follow-up ,Peg-interferon ,business.industry ,Interferon-alpha ,virus diseases ,General Medicine ,Hepatology ,Recombinant Proteins ,digestive system diseases ,HBeAg ,030220 oncology & carcinogenesis ,Peginterferon alfa-2b ,Female ,030211 gastroenterology & hepatology ,lcsh:Diseases of the digestive system. Gastroenterology ,business ,Research Article ,Follow-Up Studies ,medicine.drug - Abstract
Background Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with PEG-IFN alfa-2b from a randomized trial. Methods Eligible Chinese patients (n = 322) were followed up by one visit after a median of 6 years (LTFU) following their participation in a randomized trial evaluating the efficacy of three PEG-IFN alfa-2b dosing regimens (1.0 or 1.5 μg/kg/wk. 24 weeks or 1.5 μg/kg/wk. 48 weeks). Primary endpoints at the LTFU were sustained SR and CR (SR/CR at the end of original study [EOS] and at the LTFU). SR was defined as HBeAg loss and seroconversion to anti-HBe and CR as HBeAg loss and seroconversion to anti-HBe and HBV-DNA
- Published
- 2019