103 results on '"Young Min Ahn"'
Search Results
2. Characteristic molecular signature of pericardial effusion identifies malignant cancer in pericardial disorder patients
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Hyung Seok Kim, Hae Ok Jung, Young-Min Ahn, Hee Doo Yang, Suk Woo Nam, Min Jeong Na, Sang Yean Kim, and Jung Woo Eun
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,business.industry ,CD24 ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Cancer ,Toxicology ,medicine.disease ,Pericardial effusion ,Pathology and Forensic Medicine ,Transcriptome ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Acute pericarditis ,030220 oncology & carcinogenesis ,Malignant pericardial effusion ,Medicine ,Pericardium ,In patient ,General Pharmacology, Toxicology and Pharmaceutics ,business - Abstract
Pericardial effusion (PE) can develop in patients with virtually any condition that affects the pericardium, including acute pericarditis and a variety of systemic disorders. Thus, definite differentiation of malignant pericardial effusion and rapid diagnosis are known to have therapeutic and prognostic importance. The aim of this study was to identify novel molecular markers for the detection of cancer in patients with pericardial disorder. We performed one-way ANOVA analysis of whole transcriptome scans of 18 PEs from the patients with pericardial disorder including cancer. It resulted in 4385 outlier genes. Hierarchical clustering analysis showed two distinct clusters [cancer patient’s PEs (G1 + G2) vs. non-cancer PEs (G3)] within the dendrogram. To identify cancer-specific molecular signature, Welch’s t test of G1 and G3 was performed and 1639 gene elements were suggested as stringent classifiers between cancer PE and non-cancer PE. Gene set enrichment analysis of PE signature suggested that CD24, SDC1, and ST14 were strong molecular markers for identifying cancer patients among patients with pericardial disorder. Our results suggest that etiology-specific molecular signatures can discriminate cancer patients within pericardial disorder patients. CD24, SDC1, and ST14 are strong molecular markers for such discrimination.
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- 2020
3. A Retrospective Study on the Effect of Daeshiho-tang on the Lipid Profile in Patients with Uncontrolled Dyslipidemia by Statins
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Se-Young Ahn, Soo-min Jeong, Byung-Cheol Lee, Ji-won Noh, Jeong-hwa Yoo, Dong-Hyun Kim, and Young Min Ahn
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Ldl cholesterol ,medicine.medical_specialty ,Statin ,medicine.diagnostic_test ,medicine.drug_class ,business.industry ,Retrospective cohort study ,medicine.disease ,Total cholesterol ,Internal medicine ,medicine ,In patient ,Lipid profile ,business ,Dyslipidemia - Published
- 2019
4. Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: a multicenter retrospective study
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Son Moon Shin, Min Jeong Jang, Shinhye Hong, Jaeyoon Na, Young Min Ahn, Jong Hee Hwang, and Yong Joo Kim
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medicine.medical_specialty ,medicine.medical_treatment ,Breastfeeding ,Breast feeding ,Breast milk ,Pediatrics ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,030225 pediatrics ,Internal medicine ,Oxygen therapy ,medicine ,030212 general & internal medicine ,Respiratory syncytial virus infection ,Nutrition ,business.industry ,lcsh:RJ1-570 ,Respiratory infection ,Infant ,lcsh:Pediatrics ,Retrospective cohort study ,Odds ratio ,Intensive care unit ,Pediatrics, Perinatology and Child Health ,Original Article ,business - Abstract
Background: Breastfeeding reportedly reduces the overall frequency of infections. Respiratory syncytial virus (RSV), the most common respiratory pathogen in infants, involves recurrent wheezing and has a pathogenic mechanism related to airway structural damage.Purpose: This study aimed to investigate whether breastfeeding has a beneficial effect against RSV-induced respiratory infection compared to formula feeding among infants in Korea.Methods: We retrospectively reviewed the medical records of infants under 1 year of age who were admitted with RSV infection between January 2016 and February 2018 at the department of pediatrics of 4 hospitals. We investigated the differences in clinical parameters such as cyanosis, chest retraction, combined infection, fever duration, oxygen use, oxygen therapy duration, intensive care unit (ICU) admission, and corticosteroid treatment of exclusive breast milk feeding (BMF), artificial milk formula fed (AMF), and mixed feeding (MF) groups.Results: Among the 411 infants included in our study, 94, 161, and 156 were included in the BMF, MF, and AMF groups, respectively. The rates of oxygen therapy were significantly different among the BMF (4.3%), MF (8.1%), and AMF (13.5 %) groups (P=0.042). The odds ratios (ORs) for oxygen therapy was significantly higher in the AMF group than in the BMF group (adjusted OR, 3.807; 95% confidence interval, 1.22–11.90; P=0.021). The ICU admission rate of the BMF group (1.1%) was lower than that of the MF (3.5%) and AMF (4.5%) groups; however, the dissimilarity was not statistically significant (P=0.338).Conclusion: The severity of RSV infection requiring oxygen therapy was lower in the BMF than the AMF group. This protective role of human milk on RSV infection might decrease the need for oxygen therapy suggesting less airway damage.
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- 2019
5. The association of obstructive sleep apnea with dyslipidemia in Korean children and adolescents: a single-center, cross-sectional study
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Young Min Ahn, Min Jeong Jang, Eun Kyeong Kang, and Ki Duk Kim
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pediatric Obesity ,Adolescent ,Cross-sectional study ,Single Center ,Internal medicine ,Nonalcoholic fatty liver disease ,Republic of Korea ,medicine ,Humans ,Child ,Dyslipidemias ,Retrospective Studies ,Sleep Apnea, Obstructive ,biology ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Obesity ,Scientific Investigations ,respiratory tract diseases ,Obstructive sleep apnea ,Cross-Sectional Studies ,Neurology ,Alanine transaminase ,Child, Preschool ,biology.protein ,Neurology (clinical) ,business ,Dyslipidemia - Abstract
STUDY OBJECTIVES: To evaluate whether obstructive sleep apnea (OSA) and its severity are related to dyslipidemia and alanine transaminase elevation as a marker of nonalcoholic fatty liver disease in children. METHODS: The data collected from polysomnography, laboratory measurements (lipid profile and liver enzyme), and body mass index in children aged 0–18 years who visited the pediatric department between 2012 and 2018 were retrospectively analyzed. RESULTS: There were a total of 273 participants in the study (ages 0–6 years, 7–12 years, and 13–18 years: 61.9%, 26.4%, and 11.7%, respectively). In the ages 7–12 and 13–18 years groups, obesity was strongly associated with OSA severity (Cramer’s V = 0.498, P < .001). High-density lipoprotein cholesterol levels were significantly lower in the OSA group than in the non-OSA group, irrespective of the presence of obesity. In addition, high-density lipoprotein cholesterol levels were significantly different between the OSA severity groups after adjusting for body mass index (P = .000). In participants who were obese, moderate and severe OSA were associated with alanine transaminase elevation (P = .023 and P = .045, respectively). CONCLUSIONS: This study suggests that OSA may be an independent risk factor for dyslipidemia and that OSA and obesity have a synergistic effect on alanine transaminase elevation. Early diagnosis and treatment of OSA from childhood, especially in obese children, will reduce metabolic complications. CITATION: Kang EK, Jang MJ, Kim KD, Ahn YM. The association of obstructive sleep apnea with dyslipidemia in Korean children and adolescents: a single-center, cross-sectional study. J Clin Sleep Med. 2021;17(8):1599–1605.
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- 2021
6. Analysis of National Surveillance of Respiratory Pathogen for Children and Adolescents’ Community Acquired Pneumonia
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Eun Sil Lee, Hyo-Bin Kim, Ju-Hee Seo, JeeYoung Lee, Yang Park, Bong Seok Choi, Dong Hyuk Kim, Su Jin Lee, En Seok Yang, Hae Young Yew, Jung Yeon Shim, Hyung Min Cho, Jin Taek Kim, En Lee, Hyun Jong Yang, Ja Koung Kim, Mi Yong Shin, Eun Kyoung Kang, Hae Lee Chung, Eun-Ae Yang, Yoon Young Jang, Bong Seong Kim, Eui Jeong Roh, Seung Taek You, Man Yong Han, Mi-Hee Lee, Yoon ha Whang, Myoung Soon Sung, Sangun Jeong, Young Min Ahn, Hyoung young Kim, Eun hee Chung, Jin A Jung, Kyu Jam Whang, and Min-Ji Kim
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medicine.medical_specialty ,business.industry ,Respiratory infection ,medicine.disease ,Pneumonia ,Antibiotic resistance ,Community-acquired pneumonia ,Atypical pneumonia ,Internal medicine ,Epidemiology ,medicine ,Sputum ,Respiratory virus ,medicine.symptom ,business - Abstract
Background Respiratory infection in children is a major disease that ranks high in outpatient and inpatient cases. In particular, the causes of community acquired pneumonia (CAP) vary depending on the individual susceptibility, epidemiological characteristics of the community, and season, and it is difficult to obtain samples for microbiological diagnosis. This study analysis that laboratory surveillance network of pathogen for pediatric CAP by linking the national community-based hospital and clinics and the Centers for Disease Control and Prevention (KCDC) to identify the distribution trend and prevalence of causative pathogens and to prevent antibiotic resistance of bacterial pathogens. Method The monitoring network was composed of the 28 secondary and tertiary medical institutions based on the national community, and the 24-month prospective study operated a community monitoring network for CAP in children. Results A total of 1023 cases were registered for nasopharyngeal aspirate or sputum in patients with CAP, and 711 cases (69.5%) were isolated by culture, S. aureus 131 cases (12.8%), S. pneumonia 92 cases (9%), H. influenzae 20 cases (2%). PCR of atypical pneumonia revealed 422 cases of M. pneumoniae (41.3%), 5 cases of C. pneumonia (0.5%), and 5 case (0.5%) of B. pertussis. Respiratory virus multiplex PCR test showed positive rates in 65.7%, human rhinovirus 312 (30.5%), RSV(A+B) 212 (20.7%), Adenovirus 123 (12%), Influenza (A+B) 53 (7.8%), CoV (OC43+NL63+229E) 69 (6.7%), HMPV 81 (7.9%), HBoV 51 (5%), PIV (1+2+3+4) 65 (6.4%) and HEV 30 (2.9%) Conclusion It will identify the pathogens that cause respiratory infections, and analyze the current status of antibiotic resistance to provide scientific evidence for management policies of domestic respiratory infection. Also, in preparation for the new epidemic, including COVID19, monitoring of respiratory infections in children and adolescents, especially community pneumonia, has become more important, and research should be continuously conducted in the future. The location and extent of involvement in the medulla were the most important factors associated with the severity of dysphagia after LMI.
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- 2021
7. Immunogenicity and safety of the third booster dose of the inactivated Japanese encephalitis vaccine in Korean children: A prospective multicenter study
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Hwang Min Kim, Seon Hee Shin, Young Jin Hong, Byung Wook Eun, Young Min Ahn, Dong Hyun Kim, Byung Ok Kwak, Young Se Kwon, and Nam Hee Kim
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Pediatrics ,medicine.medical_specialty ,Adolescent ,030231 tropical medicine ,Immunization, Secondary ,Booster dose ,Antibodies, Viral ,complex mixtures ,03 medical and health sciences ,0302 clinical medicine ,Republic of Korea ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Japanese encephalitis vaccine ,Adverse effect ,Child ,Encephalitis, Japanese ,Booster (rocketry) ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Japanese Encephalitis Vaccines ,Immunogenicity ,Public Health, Environmental and Occupational Health ,Japanese encephalitis ,medicine.disease ,Antibodies, Neutralizing ,Vaccination ,Infectious Diseases ,Immunization ,Molecular Medicine ,business ,medicine.drug - Abstract
The immunization schedule for the inactivated Japanese encephalitis (JE) vaccine in Korea is a two-dose primary series at 12–24 months of age and three booster doses at 12 months after primary schedule and at 6 and 12 years of age. The aim of this study was to investigate immunogenicity and safety of the third booster dose of the inactivated JE vaccine, as well as the long-term immunogenicity of the second booster dose in Korean children. Healthy children aged 11–13 years, primed and given four doses of inactivated JE vaccines were included. All subjects received the third booster dose of the JE vaccine. Neutralizing antibody (NTAb) titers were assessed before and 4–6 weeks after vaccination using plaque reduction neutralization test (PRNT), and were considered to be protective at ≥ 1:10. Local and systemic adverse events were monitored for 4 weeks after vaccination. Before and after booster vaccination, all seroprotection rates were 100%. Geometric mean titer (GMT) showed a 6.05–fold increase, from 139.11 (95% CI: 110.76, 174.71) to 841.53 (95% CI, 714.25, 991.50). The local tolerability and systemic safety profiles were favorable, with no serious adverse events. In conclusion, the third booster dose of the inactivated JE vaccine was demonstrated to be safe and immunogenic in Korean children when administered according to the current immunization schedule.
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- 2020
8. The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 2. Management of H1-Antihistamine-Refractory Chronic Urticaria
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Kyung Hee Park, Gun Woo Kim, Sun Hee Choi, Myung Hwa Kim, Han Ki Park, Jiehyun Jeon, Young Min Ahn, Jung Min Bae, Ju Young Kim, Sang Woong Youn, Woo-Jung Song, Joong Sun Lee, Kyung Hwan Lim, Kui Young Park, Young Min Park, Dong Hun Lee, Jeong Hee Choi, Gyu Young Hur, Mihn-Sook Jue, Joo Young Roh, Dae Hyun Lim, Byung Keun Kim, Mira Choi, Jae-Woo Kwon, Hyunsun Park, Seung Eun Lee, Ji Yeon Byun, Hyo Bin Kim, Mi Ae Kim, Ji Hyun Lee, Sujeong Kim, You Hoon Jeon, Dae Jin Song, Jung Eun Kim, Min Hye Kim, Young Min Ye, Joo-Hee Kim, Yoon-Seok Chang, Hye One Kim, Hyun Jung Kim, Joung Soo Kim, and Young Bok Lee
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Evidence-based practice ,Urticaria ,medicine.medical_treatment ,Immunology ,Omalizumab ,Review ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,medicine ,Immunology and Allergy ,Dosing ,cyclosporine ,030223 otorhinolaryngology ,Adverse effect ,Intensive care medicine ,business.industry ,evidence ,leukotriene ,Evidence-based medicine ,Guideline ,030228 respiratory system ,antihistamine, treatment ,Antihistamine ,IgE ,business ,guideline ,medicine.drug - Abstract
Quite a few patients with chronic spontaneous urticaria (CSU) are refractory to H₁-antihistamines, even though the dose of H₁-antihistamines is increased up to 4-fold. CSU that is not controlled with H₁-antihistamines results in increased disease burden. Several immunomodulators have been used to manage these patients. The guidelines reported herein are connected to Part 1 of the KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children, and aimed to provide evidence-based recommendations for the management of H₁-antihistamine-refractory CSU. Part 2 focuses on the more commonly used additional treatment options for refractory CSU, including omalizumab, cyclosporine, leukotriene receptor antagonist, dapsone, methotrexate, and phototherapy. The evidence to support their efficacy, dosing, safety, and selection of these agents is systematically reviewed. To date, for patients with refractory CSU, the methodologically sound data to evaluate the use of omalizumab has been growing; however, the evidence of other immunomodulators and phototherapy is still insufficient. Therefore, an individualized stepwise approach with a goal of achieving complete symptom control and minimizing side effects can be recommended. Larger controlled studies are needed to elevate the level of evidence to select a rational therapeutic agent for patients with refractory CSU.
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- 2020
9. A Study of the Co-Administration of Herbal and Western Medicines to Hospitalized Patients with Osteoarthritis
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Young Min Ahn, Se-Young Ahn, Byung-Cheol Lee, Da-eun Lee, Ji-won Noh, and Dong-Hyun Kim
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030203 arthritis & rheumatology ,food.ingredient ,Traditional medicine ,Hospitalized patients ,business.industry ,Combined use ,food and beverages ,Osteoarthritis ,Drug interaction ,medicine.disease ,complex mixtures ,03 medical and health sciences ,0302 clinical medicine ,food ,Herb ,medicine ,030212 general & internal medicine ,Adverse effect ,business ,Western medicine ,Co administration - Abstract
Objectives: The combined use of herbal and Western medicine is increasing. However, herbal medicine is highly likely to interact with Western medicine making it important to understand the effects of co-administration. This study investigates the ratio of patients who take Western medicine with herb...
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- 2018
10. Sudden unexpected cardio-respiratory arrest after venipuncture in children
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Goun Jeong, Son Moon Shin, Young Min Ahn, and Nam Su Kim
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Pediatrics ,medicine.medical_specialty ,Patient demographics ,medicine.medical_treatment ,Respiratory arrest ,030204 cardiovascular system & hematology ,Vasovagal reaction ,Vasovagal Reaction ,03 medical and health sciences ,0302 clinical medicine ,Full recovery ,030225 pediatrics ,Medicine ,Cardiopulmonary resuscitation ,Child ,Venipuncture ,business.industry ,lcsh:RJ1-570 ,Cardiorespiratory fitness ,lcsh:Pediatrics ,Heart arrest ,Acute myocarditis ,Pediatrics, Perinatology and Child Health ,Original Article ,medicine.symptom ,business - Abstract
Purpose This study aimed to investigate the clinical and socioenvironmental characteristics of sudden cardiorespiratory arrest after venipuncture in children. Methods We conducted a retrospective email-based survey of all members of the Korean Pediatric Society. The questionnaire included items on patient demographics, socioenvironmental circumstances of the venipuncture, type of cardiorespiratory arrest, symptoms and signs, treatment, prognosis, and presumed cause of the arrest. Results Fourteen patients were identified. Of these, 13 were young children (
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- 2018
11. A Case Report on the Effect of a Short-Term Intensive Obesity Treatment on an Obese Patient
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Dong-hyeon Kim, Se-Young Ahn, Young-Min Ahn, Jung-hwa Yoo, Byung-Cheol Lee, and Da-eun Lee
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Pediatrics ,medicine.medical_specialty ,business.industry ,medicine.disease ,Obesity ,030205 complementary & alternative medicine ,Term (time) ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Edema ,Medicine ,030212 general & internal medicine ,Euphorbia kansui ,medicine.symptom ,business - Published
- 2017
12. A Case Report of Diabetic Neuropathy Treated with Korean Medicine
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Dong-Hyun Kim, Da-eun Lee, Jung-hwa Yoo, Se-Young Ahn, Young Min Ahn, and Byung-Cheol Lee
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medicine.medical_specialty ,Diabetic neuropathy ,Traditional medicine ,business.industry ,Alternative medicine ,030209 endocrinology & metabolism ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Acupuncture ,Medicine ,030212 general & internal medicine ,business - Published
- 2017
13. Sleep problems in children and adolescents at pediatric clinics
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Young Min Ahn, Cho Long Lee, and Dong Soon Kim
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Night Terrors ,Questionnaires ,medicine.medical_specialty ,Habitual snoring ,Sleep problems ,Pediatrics ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,Insomnia ,Prevalence ,Outpatient clinic ,030212 general & internal medicine ,Child ,business.industry ,Incidence (epidemiology) ,lcsh:RJ1-570 ,lcsh:Pediatrics ,medicine.disease ,Sleep in non-human animals ,nervous system diseases ,Increased risk ,Sleepwalking ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Original Article ,medicine.symptom ,business - Abstract
Purpose To investigate the frequency of childhood sleep problems at pediatric clinics in Seoul and Gyeonggi provinces. Methods Children (n=936) and their parents who visited 5 primary and 1 secondary pediatric outpatient clinics were invited to complete a Pediatric Sleep Questionnaire. Results Among patients, 901 (96.3%) answered questionnaires in sufficient detail for evaluation. The participant's mean age was 4.35±3.02 years (range, 0–18 years). The male to female ratio was 1:0.93 (466 boys, 435 girls). Habitual snoring (>3 day/week) was reported in 16.9% of the participants. The prevalence of habitual snoring in children 2 years. Insomnia was reported in 13.2% of children. The prevalence of sleepwalking, night terrors, and bruxism, is 1.6%, 19%, and 21.1%, respectively. Snoring was associated with increased incidence of sleepwalking, night terrors, and bruxism. Age was associated with insomnia and habitual snoring (P
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- 2017
14. A Survey of Korean Physicians’ Prescription Patterns for Allergic Rhinitis
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Young Min Ahn, Yong Min Kim, Sang Duk Hong, Hye Mi Jee, Min Young Seo, and Dong-Kyu Kim
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Allergic Rhinitis ,medicine.medical_specialty ,Allergen immunotherapy ,Allergy ,medicine.medical_treatment ,lcsh:Medicine ,Drug Prescriptions ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Surveys and Questionnaires ,Medicine ,General hospital ,Medical prescription ,030223 otorhinolaryngology ,Asthma ,business.industry ,lcsh:R ,lcsh:Otorhinolaryngology ,University hospital ,medicine.disease ,lcsh:RF1-547 ,030228 respiratory system ,Otorhinolaryngology ,Surgery ,Antihistamine ,Original Article ,business - Abstract
Objectives The aim of this study was to compare the prescription patterns according to characteristics of physicians using a survey distributed amongst physicians in Korea. Methods We surveyed the prescription patterns for allergic rhinitis (AR) of the members of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI) and the Korean Association of Otorhinolaryngologists (KAO). Questionnaire contained 4 categories with 28 queries. 448 physicians including 98 internal medicine (IM), 113 pediatrics (PED), and 237 otorhinolaryngology (ENT) were responded. Results Although the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines are most frequently used in all specialties, seasonal or perennial AR is the most frequent classification system. For the definitive diagnosis of AR, ENT physicians reported using multiple allergen simultaneous test (MAST)/radio allergy sorbent test (RAST) more than others (IM, 10.9%; PED, 20.6%; ENT, 44.2%; P
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- 2017
15. Hereditary angioedema in childhood
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Young Min Ahn
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medicine.medical_specialty ,Allergy ,business.industry ,MEDLINE ,lcsh:RJ1-570 ,lcsh:Pediatrics ,medicine.disease ,Pediatrics ,Dermatology ,Editorial ,Pediatrics, Perinatology and Child Health ,Hereditary angioedema ,Medicine ,business - Published
- 2020
16. Erratum: Addition of a Co-Author: Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (2006–2010): a Retrospective Multicenter Study
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Sang Hyuk Ma, Young Mi Kim, Sung Hee Oh, Jin Han Kang, Dong Soo Kim, Nam Hee Kim, Eun Hwa Choi, Dae Sun Jo, Yae Jean Kim, Chun Soo Kim, Byung Wook Eun, Jong Hyun Kim, Kun Song Lee, Hoan Jong Lee, Eun Young Cho, Jina Lee, Kyuyol Rhie, Young Jin Hong, Chi Eun Oh, Young Min Ahn, Sung Ho Cha, Yun Kyung Kim, Taekjin Lee, Young Youn Choi, Kwang Nam Kim, Hwang Min Kim, and Su Eun Park
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Pediatrics ,medicine.medical_specialty ,Multicenter study ,business.industry ,Published Erratum ,MEDLINE ,Etiology ,Medicine ,General Medicine ,business - Published
- 2019
17. Clinical characteristics and etiologies of bronchiectasis in Korean children: A multicenter retrospective study
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Ji-Won Kwon, Jung Yeon Shim, Bong Seong Kim, Eun Lee, Young Min Ahn, Young Suh Kim, Jin A Jung, Ja Hyeong Kim, Myung Chul Hyun, Hwan Soo Kim, Yang Park, So-Yeon Lee, Hyung Young Kim, Sungsu Jung, Eun Hee Chung, Gwang Cheon Jang, Soo Young Lee, Yun Jung Choi, Ju Hee Seo, Jin Tack Kim, Kyunguk Jeong, Yoon Ha Hwang, Dong In Suh, Yoon Young Jang, Joongbum Cho, Mi Hee Lee, Man Young Han, Moo Young Oh, In Suk Sol, Soo-Jong Hong, Minyoung Jung, Ahn Ji Young, Kyung Suk Baek, Meeyong Shin, and Hyeon-Jong Yang
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Pulmonary and Respiratory Medicine ,Lung Diseases ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Fever ,Heart Diseases ,Bronchiolitis obliterans ,Recurrence ,Forced Expiratory Volume ,Republic of Korea ,Medicine ,Humans ,Child ,Bronchiolitis Obliterans ,Respiratory Tract Infections ,Tuberculosis, Pulmonary ,Retrospective Studies ,Bronchiectasis ,Lung ,business.industry ,Respiratory infection ,Retrospective cohort study ,Pneumonia ,medicine.disease ,Prognosis ,Respiratory Function Tests ,Chronic cough ,medicine.anatomical_structure ,Dyspnea ,Cough ,Child, Preschool ,Etiology ,Primary immunodeficiency ,Female ,medicine.symptom ,business - Abstract
Background Bronchiectasis is a chronic pulmonary disease characterized by progressive and irreversible bronchial dilatation. The aim of the present study was to investigate the etiologies and clinical features of bronchiectasis in Korean children. Methods We performed a retrospective review of the medical records for children diagnosed with bronchiectasis between 2000 and 2017 at 28 secondary or tertiary hospitals in South Korea. Results A total of 387 cases were enrolled. The mean age at diagnosis was 9.2 ± 5.1 years and 53.5% of the patients were boys. The most common underlying cause of bronchiectasis was preexisting respiratory infection (55.3%), post-infectious bronchiolitis obliterans (14.3%), pulmonary tuberculosis (12.3%), and heart diseases (5.6%). Common initial presenting symptoms included chronic cough (68.0%), recurrent pneumonia (36.4%), fever (31.1%), and dyspnea (19.7%). The most predominantly involved lesions were left lower lobe (53.9%), right lower lobe (47.1%) and right middle lobe (40.2%). No significant difference was observed in the distribution of these involved lesions by etiology. The forced expiratory volume in 1 s (FEV1) levels were lowest in cases with interstitial lung disease-associated bronchiectasis, followed by those with recurrent aspiration and primary immunodeficiency. Conclusions Bronchiectasis should be strongly considered in children with chronic cough and recurrent pneumonia. Long-term follow-up studies on pediatric bronchiectasis are needed to further clarify the prognosis and reduce the disease burden in these patients.
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- 2018
18. A Multicenter Retrospective Case Study of Anaphylaxis Triggers by Age in Korean Children
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Gwang Cheon Jang, You Hoon Jeon, Kyung Won Kim, Yong Mean Park, Hyeon Jong Yang, Ji Won Kwon, Kyu-Earn Kim, Jinho Yu, Myung Hyun Sohn, Hyung Young Kim, Dong In Suh, So-Yeon Lee, Jihyun Kim, Soo Young Lee, Kangmo Ahn, Young Min Ahn, Woo Kyung Kim, Jung Hyun Kwon, Bok Yang Pyun, Taek Ki Min, Yong Ju Lee, Hae Ran Lee, Soo-Jong Hong, Tae Won Song, Hye Yung Yum, Hye Young Kim, Jin Tack Kim, Hyun Hee Kim, Sung-Won Kim, and Jeong Hee Kim
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Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,medicine.drug_class ,Immunology ,Antibiotics ,Milk allergy ,03 medical and health sciences ,0302 clinical medicine ,Age groups ,children ,Epidemiology ,medicine ,Immunology and Allergy ,030212 general & internal medicine ,Anaphylaxis ,Radiocontrast Media ,business.industry ,Medical record ,Retrospective cohort study ,medicine.disease ,030228 respiratory system ,Original Article ,epidemiology ,business - Abstract
PURPOSE Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups. We aimed to identify anaphylaxis triggers by age in Korean children. METHODS We performed a retrospective review of medical records for children diagnosed with anaphylaxis between 2009 and 2013 in 23 secondary or tertiary hospitals in South Korea. RESULTS A total of 991 cases (mean age=5.89±5.24) were reported, with 63.9% involving patients younger than 6 years of age and 66% involving male children. Food was the most common anaphylaxis trigger (74.7%), followed by drugs and radiocontrast media (10.7%), idiopathic factors (9.2%), and exercise (3.6%). The most common food allergen was milk (28.4%), followed by egg white (13.6%), walnut (8.0%), wheat (7.2%), buckwheat (6.5%), and peanut (6.2%). Milk and seafood were the most common anaphylaxis triggers in young and older children, respectively. Drug-triggered anaphylaxis was observed more frequently with increasing age, with antibiotics (34.9%) and nonsteroidal anti-inflammatory drugs (17.9%) being the most common causes. CONCLUSIONS The most common anaphylaxis trigger in Korean children was food. Data on these triggers show that their relative frequency may vary by age.
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- 2016
19. Herbal Acupuncture for the Treatment of Obesity
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Kwang Seok Ahn, Seung-Wook Lee, Min-Ho Nam, Byung-Cheol Lee, Se-Young Ahn, Sun-Ho Paik, Seung-Hoon Choi, Young-Min Ahn, Jeong-hwa Yoo, and Hyun-Young Na
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0301 basic medicine ,Calorie ,medicine.medical_treatment ,Bioinformatics ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Acupuncture ,medicine ,Animals ,Humans ,Insulin ,Obesity ,Traditional medicine ,Plant Extracts ,business.industry ,Leptin ,Lipid metabolism ,General Medicine ,medicine.disease ,030104 developmental biology ,Anesthesiology and Pain Medicine ,Complementary and alternative medicine ,030220 oncology & carcinogenesis ,Animal studies ,business ,Acupuncture Points - Abstract
Obesity is the state of excessive body fat accumulation and is mainly caused by consuming more calories than are burned through physical activity. Herbal acupuncture (HA), also known as pharmacopuncture, has been increasingly used in clinics of Korean medical to alleviate obesity. This review analyzed four clinical studies and 16 animal studies on the effectiveness of HA as a treatment for obesity. Clinical evidence suggests that various kinds of HA might be beneficial for treating obesity; however, further investigations with well-designed, evidence-based, randomized clinical trials are needed. Animal studies support the idea that HA might be beneficial for the treatment of obesity and provide possible mechanisms, such as anti-inflammation, antioxidation, modulating lipid metabolism and so on, to explain the effect of HA on obesity. This review, based on the evidence collected, suggests that HA could have a beneficial effect for alleviating obesity by modulating inflammation, oxidative stress, lipid metabolism, leptin, and the insulin signal.
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- 2016
20. Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer
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Hyung Seok Kim, Suk Woo Nam, Hee Doo Yang, Pum-Joon Kim, Young-Min Ahn, Jung Young Lee, Qingyu Shen, Woo Chan Shin, Won Sang Park, and Jung Woo Eun
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Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Epithelial-Mesenchymal Transition ,animal structures ,Cell cycle checkpoint ,Mice, Nude ,Transfection ,Histones ,liver cancer ,Mice ,03 medical and health sciences ,H2A.Z.1 ,Cell Movement ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Epithelial–mesenchymal transition ,Cell Cycle Protein ,Cell Proliferation ,Gene knockdown ,business.industry ,Cell growth ,Liver Neoplasms ,Cell Cycle Checkpoints ,Hep G2 Cells ,Cell cycle ,medicine.disease ,030104 developmental biology ,Oncology ,Cell culture ,embryonic structures ,Cancer research ,Heterografts ,cell cycle ,Liver cancer ,business ,Research Paper - Abstract
H2A.Z is a highly conserved H2A variant, and two distinct H2A.Z isoforms, H2A.Z.1 and H2A.Z.2, have been identified as products of two non-allelic genes, H2AFZ and H2AFV. H2A.Z has been reported to be overexpressed in breast, prostate and bladder cancers, but most studies did not clearly distinguish between isoforms. One recent study reported a unique role for the H2A.Z isoform H2A.Z.2 as a driver of malignant melanoma. Here we first report that H2A.Z.1 plays a pivotal role in the liver tumorigenesis by selectively regulating key molecules in cell cycle and epithelial-mesenchymal transition (EMT). H2AFZ expression was significantly overexpressed in a large cohort of hepatocellular carcinoma (HCC) patients, and high expression of H2AFZ was significantly associated with their poor prognosis. H2A.Z.1 overexpression was demonstrated in a subset of human HCC and cell lines. H2A.Z.1 knockdown suppressed HCC cell growth by transcriptional deregulation of cell cycle proteins and caused apoptotic cell death of HCC cells. We also observed that H2A.Z.1 knockdown reduced the metastatic potential of HCC cells by selectively modulating epithelial-mesenchymal transition regulatory proteins such as E-cadherin and fibronectin. In addition, H2A.Z.1 knockdown reduced the in vivo tumor growth rate in a mouse xenograft model. In conclusion, our findings suggest the oncogenic potential of H2A.Z.1 in liver tumorigenesis and that it plays established role in accelerating cell cycle transition and EMT during hepatocarcinogenesis. This makes H2A.Z.1 a promising target in liver cancer therapy.
- Published
- 2016
21. Autonomous Navigation and Localization of a Quadrotor in an Indoor Environment
- Author
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Young Min Ahn, Daniel J. Block, and Ramavarapu S. Sreenivas
- Subjects
Heading (navigation) ,Inertial frame of reference ,business.industry ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Aerospace Engineering ,Computer Science Applications ,Computer Science::Robotics ,On board ,Units of measurement ,Inertial measurement unit ,Global Positioning System ,Computer vision ,Artificial intelligence ,Electrical and Electronic Engineering ,Vanishing point ,business ,Inertial navigation system - Abstract
This paper describes an inertial navigation and vanishing point methodology that has been implemented using artificially placed landmarks and the sensors on board a quadrotor for autonomous navigation in a Global-Positioning-System-denied known, indoor environment. The drift in yaw was regulated using a downward-facing camera, and landmarks were placed at strategic locations. The heading was determined by the vanishing point in the image sensed by the forward-facing camera, which also helped to reduce the number of landmarks necessary for autonomous flight. The results presented in this paper suggest that the data from onboard inertial measurement units, combined with the localization method described in this paper, are sufficient to achieve autonomous indoor navigation.
- Published
- 2015
22. The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 1. Definition, Methodology and First-line Management
- Author
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Hye One Kim, Woo-Jung Song, Mi Ae Kim, Ju Young Kim, Ji Hyun Lee, Jae-Woo Kwon, Hyo Bin Kim, Sun Hee Choi, Jiehyun Jeon, Jeong Hee Choi, Ji Yeon Byun, Joung Soo Kim, Myung Hwa Kim, Gyu Young Hur, Hyun Jung Kim, Kyung Hee Park, Young Min Ahn, Sang Woong Youn, You Hoon Jeon, Hyunsun Park, Mihn-Sook Jue, Joo Young Roh, Mira Choi, Young Min Park, Min Hye Kim, Young Min Ye, Sujeong Kim, Joo-Hee Kim, Gun Woo Kim, Dae Jin Song, Jung Eun Kim, Young Bok Lee, Joong Sun Lee, Han Ki Park, Dong Hun Lee, Yoon-Seok Chang, Jung Min Bae, Kui Young Park, Seung Eun Lee, Kyung Hwan Lim, Byung Keun Kim, and Dae Hyun Lim
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,Evidence-based practice ,Urticaria ,Immunology ,Review ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,therapeutics ,medicine ,Immunology and Allergy ,Disease management (health) ,030223 otorhinolaryngology ,Intensive care medicine ,Disease burden ,Asthma ,Angioedema ,business.industry ,Guideline ,medicine.disease ,disease management ,030228 respiratory system ,medicine.symptom ,business ,guideline - Abstract
Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.
- Published
- 2020
23. Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey
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Hyeon Jong Yang, Young Il Koh, Dong-Kyu Kim, Yong Min Kim, Woo Yong Bae, Yang Park, Hyun-Jong Lee, Bong Seong Kim, Young Min Ahn, Mi Ae Kim, Hyo Yeol Kim, Jeong Hee Kim, Yunsun Kim, Jaechun Lee, Hae-Sim Park, An Soo Jang, Yi Yeong Jeong, Jeong Hee Choi, Sang Min Lee, Young Joon Jun, Dae Hyun Lim, and Young Yoo
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,Immunology ,Prevalence ,Nationwide survey ,Immunoglobulin E ,03 medical and health sciences ,0302 clinical medicine ,Food allergy ,Internal medicine ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,Asthma ,food allergy ,biology ,business.industry ,food and beverages ,Pollen-food allergy syndrome ,medicine.disease ,030228 respiratory system ,Korean melon ,pollen ,biology.protein ,Original Article ,Erratum ,business ,Anaphylaxis - Abstract
PURPOSE: Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergy in pollinosis patients caused by raw fruits and vegetables and is the most common food allergy in adults. However, there has been no nationwide study on PFAS in Korea. In this study, we investigated the prevalence and clinical characteristics of PFAS in Korea. METHODS: Twenty-two investigators participated in this study, in which patients with allergic rhinoconjunctivitis and/or bronchial asthma with pollen allergy were enrolled. The questionnaires included demographic characteristics, a list of fruits and vegetables, and clinical manifestations of food allergy. Pollen allergy was diagnosed by skin prick test and/or measurement of the serum level of specific IgE. RESULTS: A total of 648 pollinosis patients were enrolled. The prevalence of PFAS was 41.7% (n = 270). PFAS patients exhibited cutaneous (43.0%), respiratory (20.0%), cardiovascular (3.7%) or neurologic symptoms (4.8%) in addition to oropharyngeal symptoms. Anaphylaxis was noted in 8.9% of the PFAS patients. Seventy types of foods were linked to PFAS; e.g., peach (48.5%), apple (46.7%), kiwi (30.4%), peanut (17.4%), plum (16.3%), chestnut (14.8%), pineapple (13.7%), walnut (14.1%), Korean melon (12.6%), tomato (11.9%), melon (11.5%) and apricot (10.7%). Korean foods such as taro/taro stem (8.9%), ginseong (8.2%), perilla leaf (4.4%), bellflower root (4.4%), crown daisy (3.0%), deodeok (3.3%), kudzu root (3.0%) and lotus root (2.6%) were also linked to PFAS. CONCLUSIONS: This was the first nationwide study of PFAS in Korea. The prevalence of PFAS was 41.7%, and 8.9% of the PFAS patients had anaphylaxis. These results will provide clinically useful information to physicians.
- Published
- 2018
24. Incidence of cephalosporin-induced anaphylaxis and clinical efficacy of screening intradermal tests with cephalosporins: A large multicenter retrospective cohort study
- Author
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So My Koo, Young Min Ahn, Jinwoo Park, Bomi Seo, Young-Hee Nam, Sung Kook Kim, Hye Jung Park, So Young Park, Kyung Hee Park, Dong Yoon Kang, Hyeon-Jong Yang, Mi Yeong Kim, Hee Kang, Jae Woo Jung, Tae-Bum Kim, G. C. Jang, and Min Suk Yang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cefotaxime ,medicine.drug_class ,Cefepime ,Immunology ,Cephalosporin ,Cefotiam ,Drug Hypersensitivity ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Ceftizoxime ,polycyclic compounds ,medicine ,Immunology and Allergy ,Humans ,Mass Screening ,Public Health Surveillance ,030212 general & internal medicine ,Anaphylaxis ,Mass screening ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Cefminox ,Incidence ,biochemical phenomena, metabolism, and nutrition ,Intradermal Tests ,Middle Aged ,bacterial infections and mycoses ,Anti-Bacterial Agents ,Cephalosporins ,030228 respiratory system ,Female ,business ,Cefuroxime ,medicine.drug - Abstract
Background Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims of the study were to assess the incidence of cephalosporin-induced anaphylaxis and evaluate the clinical efficacy of screening skin tests. Methods In this retrospective cohort study, we obtained information on total cephalosporin use and cephalosporin-induced anaphylaxis in intravenous cephalosporin recipients in 12 general hospitals between 2013 and 2015. Cephalosporins were divided into 4 groups according to similar side-chain structures. The incidence of cephalosporin-induced anaphylaxis was assessed for each cephalosporin, cephalosporin generation, and side-chain group. To verify the efficacy of screening intradermal tests (IDT) with cephalosporin, the 12 hospitals were assigned to the intervention or control group depending on whether they performed screening IDT before the administration of cephalosporins. Results We identified 76 cases of cephalosporin-induced anaphylaxis with 1 123 345 exposures to intravenous cephalosporins (6.8 per 100 000 exposures), and the incidence of fatal anaphylaxis by cephalosporin was 0.1 cases per 100 000 exposures. The highest incidences of anaphylaxis occurred in the ceftizoxime (13.0 cases per 100 000 exposures) and side-chain group 1 (cefepime, cefotaxime, ceftizoxime, ceftriaxone, and cefuroxime; 9.3 per 100 000). There was no case of anaphylaxis induced by cefoxitin, cefmetazole, cefminox, and cefotiam. The clinical effectiveness of routine screening IDT was not significant (P = .06). Conclusions The incidence of cephalosporin-induced anaphylaxis differed according to individual drugs and side-chain structure. Screening IDT showed no clinical efficacy at a population level.
- Published
- 2018
25. Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (2006–2010): a Retrospective Multicenter Study
- Author
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Young Jin Hong, Young Min Ahn, Young Youn Choi, Kwang Nam Kim, Jin Han Kang, Dae Sun Jo, Yun Kyung Kim, Hoan Jong Lee, Kun Song Lee, Kyuyol Rhie, Eun Young Cho, Byung Wook Eun, Sung Ho Cha, Sung Hee Oh, Yae Jean Kim, Sang Hyuk Ma, Nam Hee Kim, Taekjin Lee, Jong Hyun Kim, Dong Soo Kim, Young Mi Kim, Hwang Min Kim, Su Eun Park, Chi Eun Oh, Chun Soo Kim, Eun Hwa Choi, and Jina Lee
- Subjects
Male ,Staphylococcus aureus ,medicine.medical_specialty ,Epidemiology ,medicine.disease_cause ,Streptococcus agalactiae ,Haemophilus influenzae ,Hospitals, University ,Immunocompromised Host ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,Correspondence ,Republic of Korea ,Streptococcus pneumoniae ,Escherichia coli ,Humans ,Medicine ,030212 general & internal medicine ,Retrospective Studies ,business.industry ,Infant ,Bacterial Infections ,General Medicine ,Infectious Diseases, Microbiology & Parasitology ,medicine.disease ,Pneumonia ,Child, Preschool ,Bacteremia ,Etiology ,Female ,Original Article ,business ,Meningitis - Abstract
Background Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. Methods A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. Results Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996–2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001). Conclusion S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children., Graphical Abstract
- Published
- 2018
26. Radiologic findings as a determinant and no effect of macrolideresistance on clinical course of Mycoplasma pneumoniae pneumonia
- Author
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Woo Sun Kim, Ki Wook Yun, Young Hoon Choi, Hwa Jin Cho, Hyunju Lee, Eun Hwa Choi, Eun Young Cho, In Ae Yoon, Hoan Jong Lee, Byung Wook Eun, Ji Young Park, Ki Bae Hong, and Young Min Ahn
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Mycoplasma pneumoniae ,Fever ,Resistance ,030106 microbiology ,Microbial Sensitivity Tests ,Radiologic findings ,medicine.disease_cause ,lcsh:Infectious and parasitic diseases ,Parapneumonic effusion ,03 medical and health sciences ,0302 clinical medicine ,Medical microbiology ,Nasopharynx ,Internal medicine ,Drug Resistance, Bacterial ,Pneumonia, Mycoplasma ,Republic of Korea ,medicine ,Humans ,lcsh:RC109-216 ,030212 general & internal medicine ,Child ,business.industry ,X-Rays ,Medical record ,Clinical course ,Infant ,Pneumonia ,medicine.disease ,Hospitals ,Anti-Bacterial Agents ,Infectious Diseases ,Macrolide resistance ,Parasitology ,Child, Preschool ,Immunology ,Female ,Macrolides ,Radiologicfindings ,business ,Research Article - Abstract
Background With the emergence of macrolide resistance, concerns about the efficacy of macrolides for the treatment of Mycoplasma pneumoniae (MP) pneumonia in children have been raised. This study aimed to determine the effect of macrolide resistance on the outcome of children who were hospitalized with MP pneumonia. Methods Between 2010 and 2015, we performed culture of MP from nasopharyngeal samples obtained from children who were hospitalized with pneumonia at five hospitals in Korea. Macrolide resistance was determined by the analysis of 23S rRNA gene transition and the minimal inhibitory concentrations of four macrolides. Medical records were reviewed to analyze the clinical response to treatment with macrolides. Results MP was detected in 116 (4.8%) of the 2436 children with pneumonia. MP pneumonia was prevalent in 2011 and 2015. Of the 116 patients with MP pneumonia, 82 (70.7%) were macrolide-resistant. There were no differences in the age distribution, total duration of fever, and chest x-ray patterns between the macrolide-susceptible and macrolide-resistant groups. After macrolide initiation, mean days to defervescence were longer in the macrolide-resistant group than in macrolide-susceptible group (5.7 days vs. 4.1 days, P = 0.021). However, logistic regression analysis revealed that the presence of extrapulmonary signs (P = 0.039), homogeneous lobar consolidation (P = 0.004), or parapneumonic effusion (P
- Published
- 2017
27. A multicenter study on anaphylaxis caused by peanut, tree nuts, and seeds in children and adolescents
- Author
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Taek Ki Min, Jeong Hee Kim, Yoon Hee Kim, Kyu-Earn Kim, Hyung Young Kim, Myung Hyun Sohn, Hae-Ran Lee, Kyung Won Kim, Dong In Suh, Jung Hyun Kwon, Ji-Won Kwon, Kyunguk Jeong, B. Pyun, Jihyun Kim, Soo Young Lee, So-Yeon Lee, Kangmo Ahn, Tae Won Song, You Hoon Jeon, and Young Min Ahn
- Subjects
Nut ,Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Immunology ,Immunoglobulin E ,03 medical and health sciences ,0302 clinical medicine ,Food allergy ,030225 pediatrics ,Internal medicine ,Bronchodilator ,medicine ,Immunology and Allergy ,Humans ,Child ,Anaphylaxis ,biology ,business.industry ,Infant ,Allergens ,medicine.disease ,University hospital ,Surgery ,Epinephrine ,030228 respiratory system ,Multicenter study ,Child, Preschool ,Seeds ,biology.protein ,Female ,business ,medicine.drug ,Nut and Peanut Hypersensitivity - Abstract
Peanut (PN) and tree nuts (TNs) are common causes of anaphylaxis in Western countries, but no information is available in Korea. To feature clinical characteristics of anaphylaxis caused by PN, TNs, and seeds, a retrospective medical record review was performed in 14 university hospitals in Korea (2009-2013). One hundred and twenty-six cases were identified, with the mean age of 4.9 years. PN, walnut (WN), and pine nut accounted for 32.5%, 41.3%, and 7.1%, respectively. The median values of specific IgE (sIgE) to PN, WN, and pine nut were 10.50, 8.74, and 4.61 kUA /l, respectively. Among 50 cases managed in the emergency department, 52.0% were treated with epinephrine, 66.0% with steroid, 94.0% with antihistamines, 36.0% with oxygen, and 48.0% with bronchodilator. In conclusion, WN, PN, and pine nut were the three most common triggers of anaphylaxis in Korean children, and anaphylaxis could occur at remarkably low levels of sIgE.
- Published
- 2016
28. 0740 Prevalence of Obstructive Sleep Apnea among Overweight Adolescents and Children in Korea
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Young Min Ahn and Min Jung Jang
- Subjects
Pediatrics ,medicine.medical_specialty ,Fasting lipid profile ,business.industry ,Overweight ,medicine.disease ,Obesity ,Childhood obesity ,Obstructive sleep apnea ,Insulin resistance ,Physiology (medical) ,Hyperlipidemia ,medicine ,Neurology (clinical) ,medicine.symptom ,business - Published
- 2019
29. Patients’ and doctors’ perspectives on allergen specific immunotherapy in Korea
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Jung Won Park, Man Yong Han, Young Min Ahn, Ji Hye Kim, Sang Min Lee, Jeong Hee Choi, Jae-Woo Kwon, Soo Young Lee, Jae-Woo Jung, and Yoo Seob Shin
- Subjects
business.industry ,Immunology ,Immunology and Allergy ,Medicine ,Specific immunotherapy ,business - Published
- 2019
30. Campylobacter Enteritis: Clinical Features and Laboratory Findings in Children Treated at a Single Hospital
- Author
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Na Hyun Jo, Young Min Ahn, Mi Ok Song, Won Tae Jang, and Byung Wook Eun
- Subjects
medicine.medical_specialty ,business.industry ,Campylobacter ,medicine.disease_cause ,medicine.disease ,Azithromycin ,Gastroenterology ,Campylobacter enteritis ,Enteritis ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,030225 pediatrics ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Medicine ,030212 general & internal medicine ,business ,medicine.drug - Abstract
목적: 캄필로박터 장염은 박테리아 장염의 흔한 원인 중 하나로 알려져 있다. 그러나 국내에서 소아에서의 캄필로박터 장염의 빈도와 임상 양상에 대한 연구는 드물다. 본 연구는 단일 병원 소아청소년과 환자에서 경험한 캄필로박터 장염의 빈도와 임상적 특징을 파악하고자 시행하였다. 방법: 2012년 1월부터 2017년 12월까지 을지대학교 을지병원 소아청소년과에 급성 위장관염으로 방문한 18세 이하 소아 환자로부터 대변 검체를 확보하였다. 그 중에서 배양 혹은 polymerase chain reaction을 통해 캄필로박터 장염으로 진단된 환자들의 의무기록을 후향적으로 검토하였다. 결과: 총 123명의 환자가 캄필로박터 장염을 진단받았으며 환자의 나이 중앙값은 12 세(사분위수, 8-16세)이었다. 캄필로박터 장염은 일년 내내 발생했지만 주로 6월과 9월 사이에 86명(69.9%)으로 집중적으로 발생하였다. 증상은 설사(97.6%), 발열(96.7%), 복통(94.3%), 구토(37.4%)와 두통(34.1%) 순으로 발생하였다. 복부 컴퓨터 단층 촬영은 25.2%의 사례에서 시행되었다. 다른 치료군과 비교했을 때, azithromycin 3일 요법으로 치료하는 것이 더 짧은 입원 기간과 관련이 있었다 (P
- Published
- 2019
31. Seasonal patterns and etiologies of croup in children during the period 2010–2015: A multicenter retrospective study
- Author
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Gwang Cheon Jang, Young Min Ahn, Jung Yeon Shim, In Suk Sol, Kyung Suk Lee, Sangyoung Kim, Hai Lee Chung, Yoon Young Jang, Chang-Keun Kim, Hyo Bin Kim, Eun Hee Chung, Hea Lin Oh, Man Yong Han, Chorong Park, Hyeon-Jong Yang, Bong Seong Kim, Min Seob Song, Sung Min Choi, Yong Ju Lee, Cheol Hong Kim, Yunsun Kim, Jin-Tack Kim, Jinho Yu, Ju Suk Lee, Ju Hee Seo, Eun Lee, Myongsoon Sung, Dae Jin Song, Yun Jung Choi, and Hyung Young Kim
- Subjects
Pediatrics ,medicine.medical_specialty ,Allergy ,business.industry ,Retrospective cohort study ,General Medicine ,medicine.disease_cause ,medicine.disease ,Human coronavirus ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Interquartile range ,030225 pediatrics ,Croup ,otorhinolaryngologic diseases ,medicine ,Etiology ,Rhinovirus ,business ,Asthma - Abstract
Purpose: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of para influenza virus. However, seasonal and annual epidemics of croup have not been clearly reported in Korea. This study aimed to ex amine the seasonal/annual patterns and etiologies of childhood croup in Korea during a consecutive 6-year period. Methods: Pediatric croup data were collected from 23 centers in Korea from 1 January 2010 to 31 December 2015. Electronic medi cal records, including multiplex reverse transcription polymerase chain reaction (RT-PCR) results, demographics and clinical informa tion were cross-sectionally reviewed and analyzed. Results: Overall, 2,598 childhood croup patients requiring hospitalization were identified during the study period. Among them, a total of 927 who underwent RT-PCR were included in the analysis. Males (61.5%) predominated, and most (63.0%) of them were younger than 2 years of age (median, 19 months; interquartile range, 11-31 months). Peak hospitalization occurred in 2010 and 2012 in even-numbered years, and parainfluenza virus (PIV, 39.7%) was the most common cause of childhood croup requiring hos pitalization, followed by respiratory syncytial virus (14.9%), human rhinovirus (12.5%), Mycoplasma pneumonaie (10.6%), and human coronavirus (7.3%). Conclusion: It is concluded that croup hospitalization has a biennial pattern in even-numbered years. PIV may be the most com mon cause of childhood croup; however, croup epidemics could be attributed to other viruses. (Allergy Asthma Respir Dis 2019;7:78-85)
- Published
- 2019
32. Erratum: Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey
- Author
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Sang Min Lee, Young Joon Jun, Hyo Yeol Kim, Yi Yeong Jeong, Hyun Jong Lee, An Soo Jang, Young Yoo, Dong-Kyu Kim, Yang Park, Yunsun Kim, Jaechun Lee, Young Min Ahn, Hyeon Jong Yang, Dae Hyun Lim, Bong Seong Kim, Mi Ae Kim, Jeong Hee Kim, Young Il Koh, Woo Yong Bae, Yong Min Kim, Hae-Sim Park, and Jeong Hee Choi
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,business.industry ,Family medicine ,Immunology ,Immunology and Allergy ,Medicine ,Pharmacy ,business ,Nationwide survey ,medicine.disease ,Pollen-food allergy - Published
- 2019
33. Clinical Efficacy of Allergen-Specific Immunotherapy from Patient and Physician Perspectives
- Author
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Soo Young Lee, Yoo Seob Shin, Man Yong Han, Sang Min Lee, Jae-Woo Jung, Jae-Woo Kwon, Ji Hye Kim, Jung Won Park, Jeong Hee Choi, and Young Min Ahn
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Allergy ,patient satisfaction ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Drug Prescriptions ,Severity of Illness Index ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,Physicians ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Clinical efficacy ,Child ,Aged ,Allergen immunotherapy ,Asthma ,business.industry ,Significant difference ,Infant ,Specific immunotherapy ,General Medicine ,Atopic dermatitis ,Immunotherapy ,Allergens ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Treatment Outcome ,Socioeconomic Factors ,Satisfaction rate ,Desensitization, Immunologic ,Child, Preschool ,030220 oncology & carcinogenesis ,surveys and questionnaire ,Female ,Original Article ,business - Abstract
Purpose Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic diseases, but a few allergic patients receive AIT. In this multicenter cross-sectional study, we aimed to explore patient and physician perspectives on AIT through a questionnaire survey. Materials and Methods Allergic patients who received subcutaneous immunotherapy for at least 1 year were asked to answer a questionnaire developed by an expert panel of allergen and immunotherapy workgroup in Korea. Results A total of 267 patients (adults, 60.3%) with allergic rhinitis (91.4%), asthma (42.7%), or atopic dermatitis (20.2%) from referred hospitals completed the survey. Among patients and physicians, respectively, the overall rates of satisfaction with AIT for allergic rhinitis were 86.4% and 83.3% (kappa agreement=0.234, p
- Published
- 2019
34. Acupuncture for the treatment of urinary incontinence: A review of randomized controlled trials
- Author
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Ahn Se Young, Oh‑Jun Kwon, Byung-Cheol Lee, Sun‑Ho Paik, Young-Min Ahn, and Su‑Ryun Han
- Subjects
Gynecology ,Cancer Research ,medicine.medical_specialty ,urinary incontinence ,business.industry ,leakage ,Urinary incontinence ,Acupressure ,Articles ,General Medicine ,medicine.disease ,law.invention ,Immunology and Microbiology (miscellaneous) ,Randomized controlled trial ,Overactive bladder ,Quality of life ,law ,acupressure ,medicine ,Acupuncture ,Physical therapy ,Effective treatment ,medicine.symptom ,business ,acupuncture - Abstract
The aim of this study was to examine the effects of acupuncture on urinary incontinence and to discuss why these acupoints were selected. Seven databases were searched for any randomized controlled trials (RCTs) that investigated the use of acupuncture or acupressure as a treatment for urinary incontinence, and the Cochrane risk of bias tool was utilized to evaluate the risk of bias in each study. Four RCTs met all the inclusion criteria. The results from the selected RCTs failed to demonstrate any statistically significant improvements in urinary incontinence, although acupuncture or acupressure did exhibit favorable effects on overactive bladder symptoms and quality of life, in comparison with other conventional therapies. There have been limited results supporting acupuncture or acupressure as an effective treatment method for urinary incontinence; therefore, further RCTs are required to confirm the effectiveness of acupuncture or acupressure in the treatment of urinary incontinence.
- Published
- 2013
35. DBC1 does not function as a negative regulator of SIRT1 in liver cancer
- Author
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Won Sang Park, Min Gyu Kim, Jung Young Lee, Kwang Hwa Jung, Ji Heon Noh, Jung Woo Eun, So Hee Kwon, Jeong Kyu Kim, Young-Min Ahn, Young Gyoon Chang, Hyun Jin Bae, Qingyu Shen, and Suk Woo Nam
- Subjects
Cancer Research ,endocrine system diseases ,Oncogene ,business.industry ,Cancer ,Articles ,Cell cycle ,medicine.disease ,environment and public health ,Molecular medicine ,enzymes and coenzymes (carbohydrates) ,Oncology ,Hepatocellular carcinoma ,Immunology ,Cancer research ,medicine ,biological phenomena, cell phenomena, and immunity ,Lung cancer ,business ,Liver cancer ,hormones, hormone substitutes, and hormone antagonists ,Deacetylase activity - Abstract
The putative tumor suppressor, DBC1 (deleted in breast cancer-1), was recently found to negatively regulate SIRT1 in vitro and in vivo, but the mechanism whereby DBC1 regulates SIRT1 in liver cancer remains to be elucidated. In this study, it was found that although the expression of DBC1 and SIRT1 was not aberrantly regulated in a large cohort of human hepatocellular carcinoma (HCC) patients, these proteins were highly overexpressed in a subset of HCC tissues compared with surrounding non-cancer tissues. In liver cancer, DBC1 and SIRT1 were found to be positively correlated. Inactivation of DBC1 or SIRT1 reduced SNU-182 (a liver cancer cell line) proliferation as determined by MTT viability assays. Notably, although DBC1 functions as a negative regulator of SIRT1 in A549 lung cancer cells since it suppresses the deacetylase activity of the p53 protein, it did not affect the p53 deacetylase activity of SIRT1 in SNU-182 cells. Taken together, we conclude that DBC1 is associated with SIRT1 in HCC, but that it does not inhibit SIRT1.
- Published
- 2012
36. Association between subclinical hypothyroidism and Sasang constitution in a Korean population
- Author
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Su-Ryun Han, Sung-Hwan Park, Se-Young Ahn, Young-Min Ahn, and Byung-Cheol Lee
- Subjects
Cancer Research ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Korean population ,Thyroid ,Articles ,General Medicine ,Hematocrit ,Gastroenterology ,Asymptomatic ,Endocrinology ,medicine.anatomical_structure ,Immunology and Microbiology (miscellaneous) ,Sasang constitution ,Internal medicine ,medicine ,Euthyroid ,medicine.symptom ,business ,Subclinical infection ,Hormone - Abstract
Serum thyroid-stimulating hormone screening of asymptomatic individuals to diagnose subclinical hypothyroidism remains controversial. We evaluated the potential role of Sasang constitutional discrimination and ryodoraku testing as an alternative and complementary diagnostic tool for subclinical hypothyroidism. Among 1,105 potential subjects, 1,073 were included in this study. Of these, 134 subjects had subclinical hypothyroidism (SCH) and 939 were healthy (euthyroid; EU) control subjects. Blood parameters, including serum thyroid hormone levels, were measured. We classified the participants into the four Sasang constitutional types, Taeyang-type individuals, Taeeum-type individuals, Soyang-type individuals and Soeum-type individuals, and measured their ryodoraku scores (RS). The mean levels of free thyroxine (FT4), glucose, red blood cells and hematocrit in the SCH group were significantly lower compared to those in the EU group (p
- Published
- 2012
37. The Effects of Epimedii Herba on a Hypothyroidism Rat Model induced by PTU(6-Propyl, 2-thiouracil)
- Author
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Byung Choel Lee, Young-Min Ahn, Ahn Se Young, and Min Jin Hong
- Subjects
medicine.medical_specialty ,endocrine system ,endocrine system diseases ,Rat model ,Levothyroxine ,lcsh:Medicine ,chemistry.chemical_compound ,Internal medicine ,Dry skin ,2-thiouracil ,medicine ,lcsh:Miscellaneous systems and treatments ,Kidney ,Epimedii Herba ,business.industry ,lcsh:R ,lcsh:RM1-950 ,lcsh:RZ409.7-999 ,Thiouracil ,6-Propyl ,Endocrinology ,medicine.anatomical_structure ,lcsh:Therapeutics. Pharmacology ,chemistry ,medicine.symptom ,business ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Objectives: The symptoms of hypothyroidism are fatigue, cold intolerance, arthralgia, muscle cramps, dry skin and etc. Although hypothyroidism is a relatively common endocrinical disease, we do have many difficulties treating it effectively. The symptoms of hypothyroidism are similar to those of Yang-deficiency in Oriental medicine. Epimedii Herba is a popular herb that has the effect of tonifying the kidney and strengthening Yang in Oriental medicine. In this study, we investigated the therapeutic effects of Epimedii Herba on a hypothyroidism rat model induced by PTU(6-Propyl, 2-thiouracil). Methods: 24 two-month-old Spargue-Dawley(SD) rats were divided into 4 groups: 1) normal(n=6), 2) PTU-induced hypothyroidism control(n=6), 3) hypothyroidism rat treated with Epimedii Herba(n=6), 4) hypothyroidism rat treated with levothyroxine(n=6). PTU was administered for 4 weeks, Epimedii Herba and levothyroxine was administered for 2 weeks after PTU was initiated for a total duration of 2 week. At the end of the experiment, blood samples from all the rats were taken from their hearts and were analyzed. Results: In comparison with normal group, the PTU-induced control group significantly showed hypothyroidism with low T3, T4 and high TSH. In Epimedii Herba group, T4 was significantly increased(p
- Published
- 2011
38. Sleep education in medical school curriculum: A glimpse across countries
- Author
-
Nichara Ruangdaraganon, Rini Sekartini, Jun Kohyama, Young Min Ahn, Norrashidah Abd Wahab, Alex Bartle, Mahesh Babu Ramamurthy, Jodi A. Mindell, Huynh Thi Duy Huong, Arthur Teng, and Daniel Y.T. Goh
- Subjects
Cross-Cultural Comparison ,Sleep Wake Disorders ,medicine.medical_specialty ,Asia ,Acknowledgement ,Global Health ,Nursing ,Prevalence ,medicine ,Humans ,Curriculum ,Response rate (survey) ,Education, Medical ,business.industry ,Australia ,Medical school ,General Medicine ,Cross-cultural studies ,Health Care Surveys ,Family medicine ,North America ,Sleep education ,Medical school curriculum ,Sleep (system call) ,business - Abstract
Background The objective of this study was to assess the prevalence of education about sleep and sleep disorders in medical school education and to identify barriers to providing such education. Methods Surveys were sent to 409 medical schools across 12 countries (Australia, India, Indonesia, Japan, Malaysia, New Zealand, Singapore, South Korea, Thailand, United States, Canada and Viet Nam). Results Overall, the response rate was 25.9%, ranging from 0% in some countries (India) to 100% in other countries (New Zealand and Singapore). Overall, the average amount of time spent on sleep education is just under 2.5 h, with 27% responding that their medical school provides no sleep education. Three countries (Indonesia, Malaysia, and Viet Nam) provide no education, and only Australia and the United States/Canada provide more than 3 h of education. Paediatric topics were covered for a mere 17 min compared to over 2 h on adult-related topics. Conclusion These results suggest that there continues to be very limited coverage of sleep in medical school education despite an incredible increase in acknowledgement of the importance of sleep and need for recognition of sleep disorders by physicians.
- Published
- 2011
39. Treatment of obstructive sleep apnea in children
- Author
-
Young Min Ahn
- Subjects
Pediatrics ,medicine.medical_specialty ,Diagnostic methods ,Review Article ,Disease ,stomatognathic system ,Medicine ,Endocrine system ,Maxilla-mandibular development ,Early childhood ,Child ,business.industry ,lcsh:RJ1-570 ,lcsh:Pediatrics ,medicine.disease ,respiratory tract diseases ,Adenotonsillectomy ,Obstructive sleep apnea ,Obstructive sleep apnea syndrome ,Pediatrics, Perinatology and Child Health ,Breathing ,medicine.symptom ,business ,Airway ,Weight gain - Abstract
Obstructive sleep apnea (OSA) in children is a frequent disease for which optimal diagnostic methods are still being defined. Treatment of OSA in children should include providing space, improving craniofacial growth, resolving all symptoms, and preventing the development of the disease in the adult years. Adenotonsillectomy (T&A) has been the treatment of choice and thought to solve young patient's OSA problem, which is not the case for most adults. Recent reports showed success rates that vary from 27.2% to 82.9%. Children snoring regularly generally have a narrow maxilla compared to children who do not snore. The impairment of nasal breathing with increased nasal resistance has a well-documented negative impact on early childhood maxilla-mandibular development, making the upper airway smaller and might lead to adult OSA. Surgery in young children should be performed as early as possible to prevent the resulting morphologic changes and neurobehavioral, cardiovascular, endocrine, and metabolic complications. Close postoperative follow-up to monitor for residual disease is equally important. As the proportion of obese children has been increasing recently, parents should be informed about the weight gain after T&A. Multidisciplinary evaluation of the anatomic abnormalities in children with OSA leads to better overall treatment outcome.
- Published
- 2010
40. Factors associated with chronic and recurrent rhinosinusitis in preschool children with obstructive sleep apnea syndrome
- Author
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Hyung Ho Yun, Hyun Jung Kim, and Young Min Ahn
- Subjects
Allergy ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Polysomnography ,Adenoid ,03 medical and health sciences ,0302 clinical medicine ,Adenoidectomy ,otorhinolaryngologic diseases ,medicine ,Sinusitis ,Asthma ,medicine.diagnostic_test ,business.industry ,General Medicine ,respiratory system ,medicine.disease ,respiratory tract diseases ,Obstructive sleep apnea ,Otitis ,medicine.anatomical_structure ,030228 respiratory system ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Purpose: Obstructive sleep apnea syndrome (OSAS) in young children is frequently caused by adenoid and/or tonsillar hypertro phy. Adenoidectomy is the first operative method for childhood chronic rhinosinusitis (CRS). We investigated factors associated with recurrent rhinosinusitis in preschool aged children with OSAS to determine the association of 2 common diseases. Methods: One hundred forty-six children aged 2-5 years who were diagnosed as having OSAS after polysomnography between December 2003 and April 2016 were enrolled in this study. Children were divided into 2 groups with and without CRS. The 2 groups were compared in the severity of OSAS and allergy diseases and were evaluated for recurrent rhinosinusitis during the follow-up period, 1 year after diagnosis. Results: Among 108 patients with OSAS who were followed up, 81 patients (75%) were diagnosed with CRS. There were no signifi cant difference clinical and allergic characteristics between groups with and without CRS. However, bronchial asthma and otitis me dia was significantly more prevalent in patients with CRS than in those without (P=0.045 and P=0.000, respectively). Bronchial asthma and adenotonsillectomy was significantly associated with recurrent rhinosinusitis (P=0.005 and P=0.04, respectively) dur ing the 1-year follow-up. Conclusion: Approximately 75% of preschool children with OSAS have suffered from CRS. Bronchial asthma is associated with CRS among OSAS children. Recurrent rhinosinusitis is decreased after adenotonsillectomy, and bronchial asthma is an associated factor for recurrent rhinosinusitis after a follow-up. This close relationship childhood OSAS and recurrent rhinosinusitis/bronchial asthma needs further studies to investigate their role in the association. (Allergy Asthma Respir Dis 2018;6:168-173)
- Published
- 2018
41. Literature review and future strategies of childhood respiratory diseases in Korea
- Author
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Man Yong Han, Young Min Ahn, Jung Yeon Shim, and Hai Lee Chung
- Subjects
medicine.medical_specialty ,ARDS ,Bronchiectasis ,Lung ,business.industry ,Respiratory disease ,General Medicine ,Disease ,Lung injury ,medicine.disease ,03 medical and health sciences ,Pneumonia ,0302 clinical medicine ,medicine.anatomical_structure ,Bronchiolitis ,030225 pediatrics ,medicine ,030212 general & internal medicine ,Intensive care medicine ,business - Abstract
Thirty years have passed since the Korean Association of Pediatric Allergy and Respiratory Disease was founded. There have been great changes in the pattern of respiratory diseases in Korean children during the last 30 years with economic development in the country. Pneumonia remains the leading cause of childhood morbidity, despite advances in the prevention and management. The incidence and mortality of pneumonia caused by typical bacterial pathogens have been reduced. However, the predominance of Mycoplasma pneumoniae or virus-associated diseases is emerging, which suggests that novel diagnostic and therapeutic strategies are needed. Viral bronchiolitis is one of the most substantial health burdens for infants and young children worldwide. Although re spiratory syncytial virus is the most common pathogen, molecular diagnostic techniques have identified many other viruses includ ing human rhinovirus causing bronchiolitis. Bronchiectasis is a chronic respiratory condition characterized by chronic infection, air way inflammation, and progressive lung function decline. Research into the interactions between early life respiratory infections and development of bronchiectasis is imperative to halt the disease in its origin and improve adult outcomes. Acute respiratory dis tress syndrome (ARDS) is a severe, life-threatening lung disease with diffuse inflammatory lung injury leading to pulmonary edema and hypoxia. Although many modalities to treat ARDS have been studied, supportive therapies and lung protective ventilator sup port remains the mainstay. This review focuses on the current trends in research on these childhood respiratory diseases through lit erature review and aims to investigate the impact of Korean study results in this field. (Allergy Asthma Respir Dis 2018;6 Suppl 1:S66-76)
- Published
- 2018
42. Transcriptomic configuration of mouse brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine
- Author
-
Won Sang Park, Jin Hye Min, Hongjian Xie, Jung Woo Eun, Jeong Kyu Kim, Jung Young Lee, Jae Chun Ryu, Seung Jun Kwack, Gyu Seek Rhee, Hyun Jin Bae, Ji Heon Noh, Young-Min Ahn, Suk Woo Nam, and Kwang Hwa Jung
- Subjects
Male ,N-Methyl-3,4-methylenedioxyamphetamine ,Central nervous system ,Nerve Tissue Proteins ,Toxicology ,Hippocampus ,Synaptic Transmission ,Statistics, Nonparametric ,Mice ,Mesencephalon ,Dopamine ,Cerebellum ,Pons ,mental disorders ,Monoaminergic ,medicine ,Animals ,Longitudinal Studies ,Amphetamine ,Cerebral Cortex ,Pharmacology ,Analysis of Variance ,business.industry ,Critical Period, Psychological ,Gene Expression Profiling ,Age Factors ,Neurotoxicity ,MDMA ,medicine.disease ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Anesthesia ,Cardiovascular agent ,Hallucinogens ,Female ,Serotonin ,business ,Neuroscience ,psychological phenomena and processes ,Signal Transduction ,medicine.drug - Abstract
The amphetamine derivative (+/-)-3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic amphetamine analogue used recreationally to obtain an enhanced affiliative emotional response. MDMA is a potent monoaminergic neurotoxin with the potential to damage brain serotonin and/or dopamine neurons. As the majority of MDMA users are young adults, the risk that users may expose the fetus to MDMA is a concern. However, the majority of studies on MDMA have investigated the effects on adult animals. Here, we investigated whether long-term exposure to MDMA, especially in adolescence, could induce comprehensive transcriptional changes in mouse brain. Transcriptomic analysis of mouse brain regions demonstrated significant gene expression changes in the cerebral cortex. Supervised analysis identified 1028 genes that were chronically dysregulated by long-term exposure to MDMA in adolescent mice. Functional categories most represented by this MDMA characteristic signature are intracellular molecular signaling pathways of neurotoxicity, such as, the MAPK signaling pathway, the Wnt signaling pathway, neuroactive ligand-receptor interaction, long-term potentiation, and the long-term depression signaling pathway. Although these resultant large-scale molecular changes remain to be studied associated with functional brain damage caused by MDMA, our observations delineate the possible neurotoxic effects of MDMA on brain function, and have therapeutic implications concerning neuro-pathological conditions associated with MDMA abuse.
- Published
- 2009
43. Interaction Between Warfarin andPanax ginsengin Ischemic Stroke Patients
- Author
-
Byung-Cheol Lee, Se-Young Ahn, Young-Min Ahn, Sanghun Lee, and Ho-Kyung Doo
- Subjects
Male ,medicine.medical_specialty ,Combined use ,Panax ,complex mixtures ,Brain Ischemia ,law.invention ,Ginseng ,Randomized controlled trial ,law ,Internal medicine ,Humans ,Medicine ,Drug Interactions ,cardiovascular diseases ,Aged ,Prothrombin time ,medicine.diagnostic_test ,business.industry ,Warfarin ,Anticoagulants ,Brain ,Magnetic resonance imaging ,Middle Aged ,Pharmacologic action ,Complementary and alternative medicine ,Cerebrovascular Circulation ,Ischemic stroke ,Physical therapy ,Female ,business ,medicine.drug - Abstract
Today, the combined use of Oriental herbal medicines and Western biomedical medicines has been a prevalent yet controversial practice. Case reports and healthy volunteer trials have had conflicting results on the effect Panax ginseng has on warfarin's pharmacologic action, some reporting a reductive and others a potentiating influence.This study investigated the interaction between warfarin and P. ginseng by observing the prothrombin time (PT) and the international normalized ratio (INR) in ischemic stroke patients who did not have a history of taking warfarin.Randomized, open-label, controlled study.Twenty-five (25) patients newly diagnosed with ischemic stroke by brain computed tomography or magnetic resonance imaging in the Korean Medical Hospital, Kyung Hee University (Seoul, Republic of Korea).Ischemic stroke patients were randomized into 2 groups: the ginseng group (n = 12), given both P. ginseng and warfarin, and the control group (n = 13), given only warfarin, both for 2 weeks. The warfarin dose was restricted to 2 mg in the first week and 5 mg in the second week.The peak values and the international normalized ratio (INR) and prothrombin time (PT) areas under the curve (AUC) in both groups significantly increased compared to those at baseline. However, there was no statistically significant difference in peak values and INR and PT AUC between groups in both the first and second weeks.This study suggests that coadministration of P. ginseng and warfarin in ischemic stroke patients does not influence the pharmacologic action of warfarin.
- Published
- 2008
44. An Alternative Therapy for Graves' Disease Clinical Effects and Mechanisms of an Herbal Remedy
- Author
-
Young-Min Ahn, Ho-Kyung Doo, Se-Young Ahn, Shin-Ik Kang, and Byung-Cheol Lee
- Subjects
Pharmacology ,endocrine system ,medicine.medical_specialty ,Wolff–Chaikoff effect ,Triiodothyronine ,endocrine system diseases ,business.industry ,medicine.medical_treatment ,Graves' disease ,Pharmaceutical Science ,General Medicine ,Disease ,medicine.disease ,Adenosine ,eye diseases ,Clinical trial ,Endocrinology ,Thyroid-stimulating hormone ,Internal medicine ,medicine ,Thyroglobulin ,business ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Graves' disease, the most common cause of hyperthyroidism, is an autoimmune disorder. Antithyroid drugs have been selected as the first-line treatment of Graves' disease in Korea, Japan, and European countries. However, antithyroid drugs such as methimazole (MMI) and prophylthiouracil (PTU) have limitations in clinical applications because of their side effects. In this study, we performed a clinical trial and in vitro study to investigate the clinical effects and action mechanism of Ahnjeonbaekho-tang (AJBHT), an herbal remedy for Graves' disease. In a clinical study of Graves' disease patients who had side effects from antithyroid drugs, we found that treatment by AJBHT resulted in a reduction of serum triiodothyronine (T3) and free thyroxine (FT4) levels and an increase in thyroid stimulating hormone (TSH) levels (T3: p
- Published
- 2008
45. [Untitled]
- Author
-
Young-Min Ahn, Hee-Soo Park, and Ki-Rok Kwon
- Subjects
Pharmacology ,Traditional medicine ,business.industry ,food and beverages ,Cancer ,medicine.disease ,complex mixtures ,In vitro ,chemistry.chemical_compound ,Ginseng ,Peritoneal cavity ,medicine.anatomical_structure ,Complementary and alternative medicine ,chemistry ,Apoptosis ,Cancer cell ,Medicine ,Growth inhibition ,Xanthine oxidase ,business - Abstract
Objectives : The aim of this study was to verify anti-cancer and anti-oxidant efficacies of Korean wild ginseng and cultivated wild ginseng of Korea and China. Methods : For the measurement of anti-oxidation, SOD-like activity was evaluated using xanthine oxidase reduction method under in vitro environment. Subcutaneous and abdominal cancer were induced using CT-26 human colon cancer cells for the measurement of growth inhibition of cancer cells and differences in survival rate. Results : 1. Measurement of anti-oxidant activity of ginseng, Chinese and Korean cultivated wild ginseng, and natural wild ginseng samples showed concentration dependent anti-oxidant activity in HX/XOD system. Anti-oxidant activity showed drastic increase at 1mg/ml in all samples. 2. For the evaluation of growth inhibition of cancer cells after hypodermic implantation of CT-26 cancer cells in the peritoneal cavity of mice, Chinese and Korean cultivated wild ginseng and natural wild ginseng groups showed significant inhibition of tumor growth from the 12th day compared to the control group. Similar inhibitory effects were also shown on the 15th and 18th days. But there was no significant difference between the experiment groups. 3. For the observation of increase in survival rate of the natural wild ginseng group, CT-26 cancer cells were implanted in the peritoneal cavity of mice.
- Published
- 2007
46. Peroxisome proliferator-activated receptor-γPro12Ala polymorphism is associated with the susceptibility to ischemic stroke in Taeeumin classified by Sasang medicine
- Author
-
Ho-Kyung Doo, Mee-Suk Hong, Eunyoung Ha, Kang-Hyun Leem, Sung-Vin Yim, Sang-Hyuk Byun, Soon-Il Kim, Byung-Cheol Lee, Chang-Shik Yin, Young-Min Ahn, Hun-Kuk Park, and Se-Young Ahn
- Subjects
Male ,medicine.medical_specialty ,Genotype ,Proline ,Peroxisome proliferator-activated receptor ,Gene Frequency ,Polymorphism (computer science) ,Internal medicine ,Genetic variation ,Humans ,Medicine ,Genetic Predisposition to Disease ,Philosophy, Medical ,Allele frequency ,Stroke ,Aged ,Medicine, East Asian Traditional ,chemistry.chemical_classification ,Alanine ,Polymorphism, Genetic ,business.industry ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,PPAR gamma ,Endocrinology ,Neurology ,chemistry ,Female ,Neurology (clinical) ,Restriction fragment length polymorphism ,business - Abstract
Sasang constitutional medicine classifies mankind into four constitutional types according to individual psychologic and physical traits. We hypothesized that differences among constitutional types might be explained by genetic variations.To evaluate the hypothesis, we determined the possible association in ischemic stroke patients (n = 134) of peroxisome proliferator-activated receptor (PPAR)-gamma with four constitutional types of Sasang medicine. The constitutional type of each patient and control subject (n = 129) was classified and genotyped for PPAR-gamma polymorphism Pro12Ala by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods.The distribution of the Pro/Ala genotypes in the ischemic stroke patients was not significantly different from that of healthy controls [odds ratio (OR)= 0.46; p = 0.1214]. However, very interestingly, we observed that all six Pro/Ala genotypes in ischemic patients were Taeeumin, one of four constitutional types of Sasang medicine. Statistical analysis revealed that Pro/Ala genotype in Taeeumin increases almost 15-fold the susceptibility to ischemic stroke compared to other constitutional types, Taeyangin, Soyangin or Soeumin (OR= 14.72; p = 0.0110).From the results in this study, we might suggest that Pro/Ala genotype in Taeeumin is associated with the susceptibility to ischemic stroke. To the author's best knowledge, this is the first report to study on genetic level the potential relationship between ischemic stroke and Sasang constitutional medicine, one of traditional Korean medicines (TKM). Authors hope that this study could provide a new approach for the study of ischemic stroke and merit further research.
- Published
- 2007
47. Concept-based Question Analysis for Accurate Answer Extraction
- Author
-
Seung-Eun Shin, Hee-Guen Park, Yu-Hwan Kang, Young-Min Ahn, and Young-Hoon Seo
- Subjects
Phrase ,Information retrieval ,business.industry ,Type (model theory) ,computer.software_genre ,Universal model ,Question analysis ,Frame (artificial intelligence) ,Artificial intelligence ,business ,computer ,Word (computer architecture) ,Natural language processing ,Mathematics - Abstract
This paper describes a concept-based question analysis to analyze concept which is more important than keyword for the accurate answer extraction. Our idea is that we can extract correct answers from various paragraphs with different structures when we use well-defined concepts because concepts occurred in questions of same answer type are similar. That is, we will analyze the syntactic and semantic role of each word or phrase in a question in order to extract more relevant documents and more accurate answer in them. For each answer type, we define a concept frame which is composed of concepts commonly occurred in that type of questions and analyze user`s question by filling a concept frame with a word or phrase. Empirical results show that our concept-based question analysis can extract more accurate answer than any other conventional approach. Also, concept-based approach has additional merits that it is language universal model, and can be combined with arbitrary conventional approaches.
- Published
- 2007
48. Sleep Patterns among South Korean Infants and Toddlers: Global Comparison
- Author
-
Avi Sadeh, Hyun Joo Seo, Jodi A. Mindell, Ariel A. Williamson, and Young Min Ahn
- Subjects
Cross-Cultural Comparison ,Male ,Parents ,Pediatrics ,medicine.medical_specialty ,Evening ,Breastfeeding ,White People ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,030225 pediatrics ,Surveys and Questionnaires ,Republic of Korea ,Medicine ,Humans ,Early childhood ,Survey ,Internet ,Toddlers ,Sleep hygiene ,Korea ,business.industry ,Infant ,General Medicine ,Sleep in non-human animals ,Cross-cultural studies ,Sleep patterns ,Child sleep ,Caregivers ,Child, Preschool ,Female ,Original Article ,business ,Sleep ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
The purpose of this study was to examine sleep patterns in a large sample of infants and toddlers (ages birth to 36 months) in Korea, and to compare sleep patterns, sleep problems, sleep ecology, and parental behaviors to global sleep data on young children in both predominately Asian (P-A) and predominately Caucasian (P-C) countries/regions. We additionally examined parent and child demographic information, parental behaviors, and aspects of the sleep ecology as predictors of sleep patterns among infants and toddlers in Korea. Parents/caregivers of 1,036 Korean infants and toddlers completed an expanded, internet-based version of the brief infant sleep questionnaire. Consistent with other studies of sleep in early childhood, sleep/wake patterns became increasingly consolidated with older child age for the Korea sample. Compared to both P-A and P-C infants and toddlers, children in Korea had the latest bedtimes, shortest total sleep and daytime sleep durations, and the least frequent rates of napping. Even though half of parents perceive their children’s sleep problematic, parental perceptions of severe child sleep problems were the lowest. Within Korea, breastfeeding and bottle-feeding at sleep resumption were associated with increased nocturnal awakenings. Evening television viewing was associated with later bedtimes, which may have implications for sleep hygiene recommendations in clinical practice. The current study provides important information about sleep/wake patterns, parental behaviors, and aspects of the sleep ecology for infants and toddlers for physicians to support healthy sleep in Korea., Graphical Abstract
- Published
- 2015
49. Transglutaminase 2 expressed in mast cells recruited into skin or bone marrow induces the development of pediatric mastocytosis
- Author
-
Ho Jung Lee, Sang Hoon Kim, Jai Youl Ro, Gwan Ui Hong, Kui Young Park, Young Min Ahn, Myung Nam Kim, and Hey Sung Baek
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Immunology ,Tryptase ,Bone and Bones ,Diagnosis, Differential ,Mastocytosis, Systemic ,GTP-Binding Proteins ,Predictive Value of Tests ,medicine ,Immunology and Allergy ,Humans ,Protein Glutamine gamma Glutamyltransferase 2 ,Mast Cells ,Systemic mastocytosis ,Angioedema ,Child ,Skin ,Transglutaminases ,biology ,business.industry ,Cutaneous Mastocytosis ,Chemotaxis ,NF-kappa B ,Mastocytoma ,Mast cell ,medicine.disease ,Leukotriene C4 ,Interleukin 10 ,medicine.anatomical_structure ,Phenotype ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,biology.protein ,Urticaria pigmentosa ,Cytokines ,Female ,Tryptases ,Bone marrow ,Facial Nerve Diseases ,Inflammation Mediators ,business ,Biomarkers ,Signal Transduction - Abstract
Background Mastocytosis is characterized by a pathological increase in mast cells in organs such as skin and bone marrow. Transglutaminase 2 (TG2) expressed in mast cells contributes to allergic diseases, but its role in mastocytosis has not been investigated. This study aimed to investigate whether TG2 contributes to pediatric mastocytosis. Methods Serum, various skin tissues or bone marrow (BM) biopsy and aspirates were obtained from pediatric normal control or patients with indolent systemic mastocytosis (SM), mastocytoma, and urticaria pigmentosa (UP). Tryptase, individual cytokines, leukotriene C4 (LTC4), and TG2 activity in the serum were determined by enzyme-linked immunosorbent assay, mast cell population by May–Grunwald–Giemsa, CD 117 by immunofluorescence, cell surface molecules by Western blot, and colocalization of c-kit and TG2 or IL-10-expressing cells, CD25, and FOXP3 by immunohistochemistry. Results Infiltration of CD25+CD117+CD2- mast cells into BM and scalp/trunk/ear dermis; expression of FceRI, tryptase, c-kit, FOXP3, CCL2/CCR2, and vascular cell adhesion molecule-1; and colocalization of c-kit and TG2 were enhanced in patient′s skin tissues or BM, particularly SM, but colocalization of c-kit and IL-10-expressing cells was decreased vs. normal tissues. Amounts of LTC4 and inflammatory cytokines, expression of tryptase or TG2 activity were increased in patient's serum, BM aspirates, or ear/scalp skin tissues, respectively, vs. normal persons, but IL-10 level was decreased. Conclusion The data suggest that mast cells, recruited in the skin and BM by CCL2/CCR, may induce the development of pediatric mastocytosis through reducing IL-10 due to upregulating TG2 activity via transcription factor nuclear factor-κB. Thus, TG2 may be used in diagnosis of pediatric mastocytosis, particularly SM.
- Published
- 2015
50. Susceptibility for ischemic stroke in Sasang constitutional classification is associated with the interleukin-1 receptor antagonist polymorphism
- Author
-
Ho-Kyung Doo, Young-Min Ahn, Byung-Cheol Lee, and Se-Young Ahn
- Subjects
medicine.medical_specialty ,Interleukin 1 receptor antagonist ,Complementary and alternative medicine ,Sasang constitution ,business.industry ,Internal medicine ,Anesthesia ,Ischemic stroke ,medicine ,business ,Gastroenterology - Published
- 2006
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