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Community detection is of great help to understand the structures and functions of complex networks. It has become one of popular research topics in the field of complex networks analysis. Due to the simplicity, flexibility, effectiveness and interpretability, Nonnegative Matrix Factorization (NMF)-based methods have been widely employed for community detection. However, most existing NMF-based community detection methods are linear and their performance is limited when facing networks with diversified structure information. In view of this, we propose a nonlinear NMF-based method named NMFGAAE, which is composed of two main modules: NMF and Graph Attention Auto-Encoder (GAAE). This approach can boost the performance of NMF-based community detection methods by the aid of graph neural networks and deep clustering. More specifically, GAAE introduces an attention mechanism directed by NMF-based community detection to learn the node representations, while NMF can simultaneously factor these representations to uncover the community structure. We design a unified framework to jointly optimize GAAE and NMF modules, which is very beneficial to obtain better community detection results. We conduct extensive experiments on synthetic and real-world networks. The results show that NMFGAAE not only performs better than state-of-the-art NMF-based community detection methods, but also outperforms some network representation based baselines.

Community detection is one of the popular research topics in the field of complex networks analysis. It aims to identify communities, represented as cohesive subgroups or clusters, where nodes in the same community link to each other more densely than others outside. Due to the interpretability, simplicity, flexibility, and generality, nonnegative matrix factorization (NMF) has become a very ideal model for community detection and lots of related methods have been presented. To facilitate research on NMF-based community detection, in this article, we make a comprehensive review on NMF-based methods for community detection, especially the state-of-the-art methods presented in high prestige journals or conferences. First, we introduce the basic principles of NMF and explain why NMF can detect communities and design a general framework of NMF-based community detection. Second, according to the applicable network types, we propose a taxonomy to divide the existing NMF-based methods for community detection into six categories, namely, topology networks, signed networks, attributed networks, multilayer networks, dynamic networks, and large-scale networks. We deeply analyze representative methods in every category. Finally, we summarize the common problems faced by all methods and potential solutions and propose four promising research directions. We believe that this survey can fully demonstrate the versatility of NMF-based community detection and serve as a useful guideline for researchers in related fields.

Ketogenic diet (KD) has been used to the control of seizure for 100 years because it was developed for the treatment of epilepsy in 1921. Based on current research on the microbiota-gut-brain axis to explore the new communication tool between gut bacteria and the brain and the progress of microbiota-gut-brain axis and KD for the treatment of epilepsy, the role of neurotransmitters adenosine and γ-aminobutyric acid in the epileptic brain, we propose that the balance between beneficial and harmful bacteria in the gut microbiota would be a promising target in the future to underlying the working mechanism of KD for epilepsy.

Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment of PTSD and its comorbidities.

Despite increased overall survival rates, curative options for metastatic breast cancer remain limited. We have previously shown that metadherin (MTDH) is frequently overexpressed in poor prognosis breast cancer, where it promotes metastasis and therapy resistance through its interaction with staphylococcal nuclease domain-containing 1 (SND1). Through genetic and pharmacological targeting of the MTDH–SND1 interaction, we reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer. The MTDH–SND1 complex reduces tumor antigen presentation and inhibits T cell infiltration and activation by binding to and destabilizing Tap1/2 messenger RNAs, which encode key components of the antigen-presentation machinery. Following small-molecule compound C26-A6 treatment to disrupt the MTDH–SND1 complex, we showed enhanced immune surveillance and sensitivity to anti-programmed cell death protein 1 therapy in preclinical models of metastatic breast cancer, in support of this combination therapy as a viable approach to increase immune-checkpoint blockade therapy responses in metastatic breast cancer. Kang and colleagues demonstrate that pharmacological targeting of the MTDH1–SND1 axis prevents immune evasion during metastatic progression and provides a synergistic combination strategy with immune-checkpoint blockade to treat metastasis.

Background Radiomics may provide more objective and accurate predictions for extrahepatic cholangiocarcinoma (ECC). In this study, we developed radiomics models based on magnetic resonance imaging (MRI) and machine learning to preoperatively predict differentiation degree (DD) and lymph node metastasis (LNM) of ECC. Methods A group of 100 patients diagnosed with ECC was included. The ECC status of all patients was confirmed by pathology. A total of 1200 radiomics features were extracted from axial T1 weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion weighted imaging (DWI), and apparent diffusion coefficient (ADC) images. A systematical framework considering combinations of five feature selection methods and ten machine learning classification algorithms (classifiers) was developed and investigated. The predictive capabilities for DD and LNM were evaluated in terms of area under precision recall curve (AUPRC), area under the receiver operating characteristic (ROC) curve (AUC), negative predictive value (NPV), accuracy (ACC), sensitivity, and specificity. The prediction performance among models was statistically compared using DeLong test. Results For DD prediction, the feature selection method joint mutual information (JMI) and Bagging Classifier achieved the best performance (AUPRC = 0.65, AUC = 0.90 (95% CI 0.75–1.00), ACC = 0.85 (95% CI 0.69–1.00), sensitivity = 0.75 (95% CI 0.30–0.95), and specificity = 0.88 (95% CI 0.64–0.97)), and the radiomics signature was composed of 5 selected features. For LNM prediction, the feature selection method minimum redundancy maximum relevance and classifier eXtreme Gradient Boosting achieved the best performance (AUPRC = 0.95, AUC = 0.98 (95% CI 0.94–1.00), ACC = 0.90 (95% CI 0.77–1.00), sensitivity = 0.75 (95% CI 0.30–0.95), and specificity = 0.94 (95% CI 0.72–0.99)), and the radiomics signature was composed of 30 selected features. However, these two chosen models were not significantly different to other models of higher AUC values in DeLong test, though they were significantly different to most of all models. Conclusion MRI radiomics analysis based on machine learning demonstrated good predictive accuracies for DD and LNM of ECC. This shed new light on the noninvasive diagnosis of ECC.

The relational database service in cloud usually achieves energy efficiency by using virtualization technology, in which it consolidates multiple independent database systems into a single physical machine while enforcing the hardware-level isolation among them. However, the disk I/O performance is inevitably hurt due to the resource contention on the shared device. We propose VMSQL, a novel disk I/O model for the virtualized relational database management system (RDBMS). VMSQL has two innovations over the original disk model of virtualized database systems. First, VMSQL enforces the synchronous operation in guest operating system to handle with the transaction commitment. Due to its simplicity, a portion of CPU cycles is decoupled from I/O buffer management and then used to serve the upcoming requests, thereby improving their response times. Second, in host system, VMSQL asynchronizes the storage path of transactions which are committed from the different co-located guest databases. An obvious advantage of this procedure is that systems can apply host-level improvements into the disk I/O performance of virtualized RDBMS, relieving the random I/O and enhancing the throughput of whole system. We implement a prototype of this Sync-Async model in QEMU-KVM hypervisor, in which the InnoDB engine is deployed in the guest operating system. Extensive experiments are conducted to verify its advantages and the results are positive without any loss of ACID-compliance. In the meanwhile, VMSQL incurs moderate overhead at the hypervisor layer.

Background Treatment options for refractory metastatic colorectal cancer (mCRC) were limited. Anlotinib is a novel multitarget tyrosine kinase inhibitor. ALTER0703 study was conducted to assess efficacy and safety of anlotinib for patients with refractory mCRC. Materials and Methods This was a multicenter, double-blinded, placebo-controlled, randomized phase III trial involving 33 hospitals in China. Patients had taken at least two lines of therapies were 2:1 randomized to receive oral anlotinib (12 mg/day; days 1–14; 21 days per cycle) or placebo, plus best supportive care. Randomization was stratified by previous VEGF-targeting treatments and time from diagnosis to metastases. The primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), quality of life (QoL), and safety. Results A total of 419 patients (anlotinib: 282; placebo: 137) were treated from December 2014 to August 2016. The median PFS was improved in anlotinib group (4.1 months; 95% confidence interval [CI], 3.4–4.5) over placebo group (1.5 months; 95% CI, 1.4–1.5), with a hazard ratio (HR) of 0.34 (95% CI, 0.27–0.43; p < .0001). However, median OS was similar between two groups (8.6 months; 95% CI, 7.8–9.7 vs. 7.2 months; 95% CI, 6.2–8.8; HR, 1.02; p = .870). Improvements of ORR and DCR were observed in anlotinib over placebo. The most common grade ≥ 3 anlotinib related adverse events were hypertension (20.92%), increased γ-GT (7.09%), and hand-foot skin reaction (6.38%). Conclusion Anlotinib was tolerated in Chinese patients with refractory mCRC. Although OS did not reach significant difference, anlotinib still provided clinical benefits by substantially prolonged PFS in these patients. Implications for Practice In this randomized clinical trial that included 419 patients with refractory metastatic colorectal cancer, substantial prolonged in progression-free survival was noted in patients who received anlotinib compared with those given placebo. Improvements on objective response rate and disease control rate was also observed in anlotinib group. However, overall survival was similar between the two groups. In a word, in third-line or above treatment of Chinese patients with refractory metastatic colorectal cancer, anlotinib provided clinical benefit by significantly prolonged progression-free survival.

Laser-driven illumination has unique advantages in high-power applications. Taking advantage of the valuable experience of light-emitting diodes (LED) development, phosphor in silicone (PiS) is considered to be one of the most potential commercial phosphor converter solutions for laser-driven illumination. However, the thermal quenching of the PiS converter is a bottleneck problem. Herein, a boron nitride (BN)-coated copper foam strategy is introduced for the laser-driven illumination system. The phosphor/silicone is embedded in the designed BN/copper foam to form a phosphor in metal (PiM) converter. Copper foam serves as an internal connected heat transfer channel; the BN coating solves the light absorption problem of the copper foam effectively. Based on this PiM(BN/copper foam) design, the heat dissipation is effectively improved. Under high-power laser excitation (8.13 W), the PiS converter cannot reach thermal equilibrium, and therefore the temperature increases sharply up to 660 °C. In comparison, the thermal performance of an optimized PiM(BN/copper foam) converter is able to maintain excellent stability, where the maximum temperature is only 166.5 °C. The proposed PiM strategy has a maximum temperature that is 493.5 °C lower than that of the reference PiS solution. Due to the superior thermal management, the luminous efficiency of the illumination system is constantly stable at 254 lm/W, though with less phosphor mass; and the related color temperature is about 6000 K all the time. This provides a practical and feasible heat-dissipation solution for high-power laser-driven illumination.

Erectile dysfunction (ED) is a common male disorder. Although orally-administered phosphodiesterase type 5 inhibitors (PDE5 inhibitors) are now recognized as the primary pharmacological treatment method for ED, 20%-30% of the patients treated with PDE5 inhibitors exhibit no significant effects. This study aims to investigate the influencing factors of ED in young adults with no response to PDE5 inhibitors. ED patients who would take PDE5 inhibitors were included and investigated with a questionnaire. Patients with no response to PDE5 inhibitors (tadalafil and sildenafil) served as study group, and those with response to PDE5 inhibitors as control group. Then Chi square test and logistic regression analysis were applied to find the potential influencing factors. In total, 378 ED patients were included. Ninety-three (24.6%) cases were non-responsive to PDE5 inhibitors, and the remaining 285 (75.4%) responded to PDE5 inhibitors. In multiple logistic regression analysis, we found that history of drinking (OR=3.152; 95%CI 1.672-6.975), spousal noncooperation (OR=2.994; 95%CI 1.589-5.638), number of fixed sex partners (OR=0.358; 95%CI 0.132-0.651), duration of ED (OR=3.356; 95%CI 1.352-8.333), and depression (OR=3.689; 95%CI 1.579-8.979) could be the influencing factors for ED patients' non-response to PDE5 inhibitors. In conclusion, history of drinking, spousal noncooperation, number of fixed sex partner, long duration of ED, and depression could be the influencing factors for ED patients' non-response to PDE5 inhibitors. Patients and doctors should pay attention to these factors.

Based on our previous successful material-level verification of a shape-memory polymer composite (SMPC) on the SJ-17 geostationary satellite on a geostationary orbit since November 2016, a structur...

Objective This study aimed to explore the clinical application of three-dimensional (3D) printing technology in the surgical treatment of congenital scoliosis caused by hemivertebrae. Methods Twenty-four patients (11 in the 3D-printing group and 13 in the conventional group) with scoliosis secondary to a single hemivertebra were retrospectively reviewed. All patients underwent hemivertebrectomy and short-segment fixation. Virtual preoperative planning, operation simulation, and intraoperative application of 3D-printed patient-specific templates were performed in the 3D-printing group. Hemorrhage volume, operation time, transfusion, and complications were noted. Radiographic parameters were evaluated preoperatively, postoperatively, and at final follow-up. Results All patients had different degrees of successfully corrected scoliosis. There was a similar correction of the Cobb angle postoperatively between the 2 groups. The operation time, blood loss, transfusion, time for the insertion of each screw, accuracy of screw placement, and complication rate in the 3D-printing group were significantly superior to those in the control group. No patient experienced major complications. No significant correction loss or instrument dysfunction was observed during follow-up. Conclusions As a viable and effective auxiliary technology, 3D printing makes it possible for surgery to meet both surgeon-specific and patient-specific requirements. 3D-printed individualized templates allow surgery for the correction of congenital scoliosis to enter a new stage of personalized precision surgery.

Gut microbial dysbiosis and alteration of gut microbiota composition in Parkinson's disease (PD) have been increasingly reported, no recognized therapies are available to halt or slow progression of PD and more evidence is still needed to illustrate its causative impact on gut microbiota and PD and mechanisms for targeted mitigation. Epidemiological evidence supported an association between milk intake and a higher incidence of Parkinson's disease (PD), questions have been raised about prospective associations between dietary factors and the incidence of PD. Here, we investigated the significance of casein in the development of PD. The mice were given casein (6.75 g/kg i.g.) for 21 days after MPTP (25 mg/kg i.p. × 5 days) treatment, the motor function, dopaminergic neurons, inflammation, gut microbiota and fecal metabolites were observed. The experimental results revealed that the mice with casein gavage after MPTP treatment showed a persisted dyskinesia, the content of dopamine in striatum and the expression of TH in midbrain and ileum were decreased, the expression of Iba-1, CD4, IL-22 in midbrain and ileum increased continuously with persisted intestinal histopathology and intestinal barrier injury. Decreased intestinal bile secretion in addition with abnormal digestion and metabolism of carbohydrate, lipids and proteins were found, whereas these pathological status for the MPTP mice without casein intake had recovered after 24 days, no significant differences were observed with regard to only treated with casein. Our study demonstrates that intestinal pathologic injury, intestinal dysbacteriosis and metabolism changes promoted by casein in MPTP mice ultimately exacerbated the lesions to dopaminergic neurons.

The stage T1 urothelial bladder cancer (T1 UBC) tumor grade classification is important for prognosis and clinical management. However, the reproducibility of this two-grade classification system is limited in regards to pathological diagnosis, and there is lack of ideal, objective and easily detected markers for pathological diagnosis. In our study, bladder urothelial lesions from a total of 124 patients diagnosed pathologically after transurethral resection of the bladder tumor (TURBT) were collected, including non-cancerous lesions from 33 patients and lesions from 91 T1 UBC patients. A series of previous studies have suggested some common and valuable factors in the diagnosis and prognosis of UBC, but there are still some controversial factors, such as the mitotic figure (MF) of tumor cell, cell proliferation index Ki-67, graded differentiation marker CK20, P53, P504S and carcinogenesis associated telomerase reverse transcriptase (TERT) promoter mutations. The purpose of this study was to evaluate the value of these factors in the pathological grading diagnosis of T1 UBC. The results showed that gender, lesion size, mitotic index (MI), CK20, P53, Ki-67, P504S and TERT promoter hot spot mutations (C228T and C250T) were correlated with T1 UBC diagnosis (P

Self-accelerating beams have the unusual ability to remain diffraction-free while undergo the transverse shift during the free-space propagation. We theoretically identify that the transverse optical field distribution of 2D self-accelerating beam is determined by the selection of the transverse Cartesian coordinates, when the caustic method is utilized for its trajectory design. Based on the coordinate-rotation method, we experimentally demonstrate a scheme to flexibly manipulate the rotation of transverse optical field for 2D self-accelerating beams under the condition of a designated trajectory. With this scheme, the transverse optical field can be rotated within a range of 90 degrees, especially when the trajectory of 2D self-accelerating beams needs to be maintained for free-space photonic interconnection.

Background Currently, there are no randomized trials on the effect of antiangiogenic therapy in patients with esophageal squamous cell carcinoma (ESCC). The following study investigated the efficacy and safety of anlotinib in patients with advanced ESCC who were previously treated with chemotherapy. Methods This randomized, placebo‐controlled, double‐blind phase 2 trial (NCT02649361) was conducted in 13 Chinese hospitals. Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC who were previously treated with chemotherapy, and were randomly assigned (2:1) to receive oral anlotinib 12 mg or placebo on days 1–14 (repeated every 21 days). The primary endpoint was progression‐free survival (PFS). Results One hundred and sixty‐five patients were randomly assigned to the anlotinib (n = 110) or the placebo (n = 55) arm. Median PFS was 3.02 months (95% CI 2.63–3.65) in the anlotinib group and 1.41 months (95% CI 1.38–1.41) in the placebo group (hazard ratio 0.46 [95% CI 0.32–0.66]; p, Anti‐angiogenic multi‐target inhibitor anlotinib significantly improved PFS and DCR compared with placebo in this study. Our findings demonstrated that angiogenesis targeting therapy might be an efficient therapeutic target in advanced or metastatic ESCC.

Visible light communication (VLC) is considered as a significant technology for new-generation communication. The VLC is supposed to provide high data rates and steady network links, which has high potential in dynamic wireless network transmission such as vehicle-to-vehicle communication. However, V2V network is always dynamic, which needs the receiver of the VLC system to have a large field of view (FOV) for stable networking. In this article, we proposed a sandwich structure light-trapping fluorescence antenna (LTFA). The LTFA consists of a short-wavelength pass long-wavelength reflect (SPLR) filter, a reflected mirror, and a 625-nm CdSe/ZnS quantum dots (QDs) fluorescent layer sandwiched between them. Multiple sets of variables of LTFA have been studied for optimization. A V2V VLC (V2V-VLC) system was built based on a commercial laser headlight. The FOV performance showed that a receiver with LTFA provides an incredible increment on receiving FOV, from 30° to 80°, while remaining considerable receiving signal power with an average optical gain of 1.6 for 80° FOV and an average optical gain of 10.45 for outer FOV. With the proposed LTFA, the average signal-to-noise ratio (SNR) of the V2V-VLC system can be improved 49% at 0°–80° and 123% at 30°–80°, respectively, showing promising communication performance.

Ultraviolet light-emitting diodes (UVLEDs) used as excitation sources for quantum dots (QDs) are promising candidates for the display field. To eliminate the residual excitation light, the conventional method is simply increasing the optical density of QDs for packaging, which would significantly reduce the luminous efficiency of QD-light-emitting diode (LED) devices owing to reabsorption loss. In this study, the combination strategy of a boron nitride (BN) reflective coating and an ultraviolet-reflection filter (UV-R filter) for QD-LED devices is proposed. By managing the recycle of UV light to excite more QDs and reducing the reabsorption effect of QDs carefully, their green emission intensity of LED using such a strategy is 82.0% higher than that of a conventional device with a similar QD light energy proportion of ~99.0% (almost no residual UV excitation light). This strategy is also effective for red QD-LED devices while eliminating residual UV excitation light and enhancing the red emission intensity. Therefore, this study provides an effective way to develop QD-LED devices with high QD emission intensity and low UV light leakage for display.

Targeting the SARS-CoV-2 main protease Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines. The viral protein main protease is required for cleaving precursor polyproteins into functional viral proteins. This essential function makes it a key drug target. Qiao et al. designed 32 inhibitors based on either boceprevir or telaprevir, both of which are protease inhibitors approved to treat hepatitis C virus. Six compounds protected cells from viral infection with high potency, and two of these were selected for in vivo studies based on pharmokinetic experiments. Both showed strong antiviral activity in a mouse model. Science, this issue p. 1374, Designed SARS-CoV-2 Mpro (main protease) inhibitors display excellent antiviral activity both in vitro and in a transgenic mouse model., The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continually poses serious threats to global public health. The main protease (Mpro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing Mpro inhibitors derived from either boceprevir or telaprevir, both of which are approved antivirals. All compounds inhibited SARS-CoV-2 Mpro activity in vitro, with 50% inhibitory concentration values ranging from 7.6 to 748.5 nM. The cocrystal structure of Mpro in complex with MI-23, one of the most potent compounds, revealed its interaction mode. Two compounds (MI-09 and MI-30) showed excellent antiviral activity in cell-based assays. In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment with MI-09 or MI-30 significantly reduced lung viral loads and lung lesions. Both also displayed good pharmacokinetic properties and safety in rats.

By using the latest geological, seismic, drilling and logging data, this article studies the basic conditions for the formation of the total petroleum system and the orderly coexisting characteristics and accumulation models of conventional & unconventional reservoirs in the Lower Permian Fengcheng Formation in the Junggar Basin. Controlled by thermal evolution, hydrocarbon generation and expulsion process of the high-quality source rocks in alkaline lake as well as the characteristics of multi-type reservoirs (conglomerate, sandstone, dolomite and shale), conventional structure-lithologic reservoirs and tight oil and shale oil reservoirs controlled by source-reservoir structure have been formed. On the plane, mature conventional reservoirs, medium-high mature tight oil, and medium-high mature shale oil reservoirs coexist orderly from the slope area around Mahu sag to the sag. Based on the orderly coexisting characteristics of conventional and unconventional reservoirs in the Fengcheng Formation, it is clear that oil and gas in the Fengcheng Formation accumulate continuously over a large area in three accumulation models: integrated source-reservoir, source-reservoir in close contact, and separated source-reservoir model. The three accumulation models differ in relationship between source-reservoir structure, reservoir lithology and spatial distribution, hydrocarbon migration, oil and gas type. It is pointed out that the conventional & unconventional oil and gas should be explored and developed as a whole to achieve an overall breakthrough of the total petroleum system. This study is expected to enrich the geological theory of oil and gas enrichment in continental basins and to provide an analogy for exploration and research in other hydrocarbon-rich sags.

A novel combined prediction approach including nonlinear data analysis, data decomposition and reconstruction, and parameter optimization is proposed to improve the accuracy of ultra-short-term wind power prediction. The distance correlation coefficient (DCC) is applied to analyze the non-linear correlation between wind power and numerical weather prediction (NWP) data. The original wind power is decomposed by the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) technique to eliminate the noise of the data, and then the decomposed wind power is reconstructed into new subsequences by weight permutation entropy (WPE) according to time series complexity. The least squares support vector machine (LSSVM) prediction model based on the kernel function switch mechanism is developed by the use of the new subsequence and key factor as input variables. Furthermore, an improved cuckoo search (ICS) strategy is established to optimize the penalty factor and kernel function parameters of the prediction model. The validation of the proposed model is tested with data from four actual wind farms at a large wind farm base in Northeast China. The results show that the proposed approach is effective with higher accuracy compared with other prediction approaches.

Background Diffuse large B‐cell lymphoma (DLBCL) patients refractory to rituximab‐based immunochemotherapy have a dismal prognosis. However, the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries. To validate the definition and outcomes of refractory DLBCL in China, we conducted a multicenter, retrospective cohort study. Methods The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL (REAL‐TREND) study was performed using real‐world data from 8 centers in China. DLBCL patients with curative intent were included in the REAL‐TREND dataset. Overall survival (OS) was estimated using the Kaplan‐Meier method and compared by the log‐rank test. Due to heterogeneity in response rates among different centers, the response rates of refractory patients were pooled using random‐effect models. Multivariate survival analysis was performed using the Cox regression model. Results A total of 2778 DLBCL patients diagnosed between January, 2010 and December, 2015 were enrolled to this study. After validating previous definitions, the SCHOLAR‐1 study was most suitable to define refractory DLBCL. The estimated 5‐year cumulative incidence of refractory patients was 20% (95% confidence Interval [CI] = 18%‐22%). After the determination of refractory disease, overall response rate and complete remission rate were 30% (95% CI = 22%‐38%) and 9% (95% CI = 4%‐15%), respectively. Patients with either no response to immunochemotherapy or relapse within 12 months after stem‐cell transplantation had inferior survival with a median OS of 5.9 months (95% CI = 5.5‐7.1 months) and 2‐year OS rate of 16% (95% CI = 12%‐20%). International prognostic index score 4‐5 (hazard ratio [HR] = 2.22; 95% CI = 1.47‐3.35), central nervous system relapse (HR = 1.43; 95% CI = 1.04‐1.97), and best response status (HR = 2.68; 95% CI = 1.42‐5.03 for partial remission. HR = 5.97, 95% CI = 3.21‐11.11 for stable disease/progressive disease) were independent unfavorable prognostic factors. Conclusions This is the first large‐scale Asian cohort study focusing on outcomes of refractory DLBCL. The definition of the SCHOLAR‐1 study identifies patients with homogenously inferior survival, thus is appropriate to select refractory DLBCL. Due to poor clinical outcomes in the rituximab era, patients with refractory DLBCL may be potential candidates for novel treatment modalities.

Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis. Using specific keywords and related words, we searched PubMed, Embase, and Cochrane Library databases. The Newcastle–Ottawa Scale form was used to evaluate the quality of the literature. According to the inclusion and exclusion criteria, we systematically screened the literature to extract relevant information and data. ReVman 5.3 and Stata 13.0 software were used for statistical analysis. Results were expressed as the mean difference (MD) and 95% confidence interval (95% CI). The heterogeneity test was conducted according to I2 and Q tests. Egger’s test was used to quantitatively evaluate publication bias. This analysis involved 12 studies (12,395 subjects). The quality of the literature was acceptable. Among subjects who were not taking lipid-lowering drugs, total cholesterol (TC) (MD = 0.11 mmol/L, 95%CI: − 0.03, 0.25; I2 = 21%; P = 0.36), triglycerides (TG) (MD = − 0.01 mmol/L, 95%CI: − 0.09, 0.07; I2 = 6%; P = 0.34), and low-density lipoprotein cholesterol (LDL-C) (MD = 0.10 mmol/L, 95%CI: 0.00, 0.19; I2 = 0%; P = 0.74) in the osteopenia were not significantly increased/decreased. There were no significant differences in LDL-C (MD = 0.02 mmol/L, 95%CI: − 0.09, 0.13; I2 = 0%; P = 0.74) in postmenopausal women in osteopenia. TG (MD = − 0.04 mmol/L, 95%CI: − 0.14,0.07; I2 = 49%; P = 0.07) was unchanged in the osteoporosis (OP) group in subjects without taking lipid-lowering drugs. HDL-C was elevated in OP group (MD = 0.05 mmol/L, 95%CI: 0.03, 0.07; I2 = 31%; P = 0.15) but not in osteopenia group (MD = 0.01 mmol/L, 95%CI: − 0.01, 0.02; I2 = 38%; P = 0.14) in all subjects. HDL-C was elevated in patients with OP.

Background Macroscopic hematuria after wasp sting has been reported in Asia to occur before acute kidney injury (AKI), and is often used by clinicians as a sign indicating the need for intensive care and blood purification therapy. However, there is no study on the clinical characteristics and prognosis of this symptom. Methods The clinical data of 363 patients with wasp sting admitted to Suining Central Hospital from January 2016 to December 2018 were retrospectively analyzed. At admission, the poisoning severity score (PSS) was used as the criterion for severity classification. According to the presence of macroscopic hematuria, the patients were divided into macroscopic hematuria and non-macroscopic hematuria group. Results Of the 363 wasp sting patients, 219 were male and 144 were female, with a mean age of 55.9 ± 16.3 years. Fifty-one (14%) had macroscopic hematuria, 39 (10.7%) had AKI, 105 (28.9%) had rhabdomyolysis, 61 (16.8%) had hemolysis, 45 (12.4%) went on to received hemodialysis, and 14 (3.9%) died. The incidence of AKI in macroscopic hematuria group was 70.6%, and oliguric renal failure accounted for 72.2%. Patients with macroscopic hematuria had significantly higher PSS (2.2 ± 0.5 vs. 1.1 ± 0.3, p

Objective Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer (mCRC) worldwide and was approved in China in 2010. However, there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with mCRC. This observational, phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC patients. Methods Between September 2013 and November 2016, patients with histologically confirmed mCRC were enrolled in a prospective, multicenter, observational, non-interventional phase IV trial at 26 centers across China. Eligible patients received different chemotherapeutic regimens combined with bevacizumab. The efficacy and safety data in the intention-to-treat study population were analyzed. Results A total of 611 patients were included in the efficacy analysis. The median overall survival and median progression-free survival was 18.00 and 10.05 months, respectively. The objective response rate was 21.00% and disease control rate was 89.40%. In subgroup analyses, the survival differences were observed according to metastatic status, duration of treatment and elevation in blood pressure. A total of 613 patients were evaluable for safety assessments. And 569 (92.82%) patients reported at least one adverse event (AE), and 151 (24.63%) experienced grade 3 or higher AEs. The incidence of bevacizumab-associated AEs of special interest was reported in 31 (5.06%) patients with hypertension (n=12), abscesses and fistulae (n=7), bleeding (n=6), proteinuria (n=3), gastrointestinal perforation (n=2) and venous thrombotic events (n=1). Conclusions This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and safety. Bevacizumab in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acceptable and manageable safety profile.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent responsible for the global coronavirus disease 2019 (COVID-19) pandemic. Numerous studies have demonstrated that cardiovascular disease may affect COVID-19 progression. In the present study, we investigated the effect of hypertension on viral replication and COVID-19 progression using a hypertensive mouse model infected with SARS-CoV-2. Results revealed that SARS-CoV-2 replication was delayed in hypertensive mouse lungs. In contrast, SARS-CoV-2 replication in hypertensive mice treated with the antihypertensive drug captopril demonstrated similar virus replication as SARS-CoV-2-infected normotensive mice. Furthermore, antihypertensive treatment alleviated lung inflammation induced by SARS-CoV-2 replication (interleukin (IL)-1β up-regulation and increased immune cell infiltration). No differences in lung inflammation were observed between the SARS-CoV-2-infected normotensive mice and hypertensive mice. Our findings suggest that captopril treatment may alleviate COVID-19 progression but not affect viral replication.严重急性呼吸系统综合症冠状病毒2型 (SARS-CoV-2) 是导致全球2019冠状病毒病 (COVID-19) 大流行的病原体。大量研究表明，心血管疾病可能会影响COVID-19的进展。在该研究中，我们使用感染了 SARS-CoV-2 的高血压小鼠模型研究了高血压对病毒复制和 COVID-19 进展的影响。结果显示，在高血压小鼠的肺中SARS-CoV-2的复制延迟。相比之下，用抗高血压药物卡托普利治疗的高血压小鼠的SARS-CoV-2 复制与感染了SARS-CoV-2 的正常血压小鼠的病毒复制相似。此外，抗高血压治疗减轻了由 SARS-CoV-2 复制引起的IL-1β上调和免疫细胞浸润增加。在感染 SARS-CoV-2 的血压正常小鼠和高血压小鼠之间没有观察到肺部炎症的差异。因此，我们的研究结果初步表明，卡托普利治疗可能会缓解COVID-19的进展，但不会影响病毒复制。.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) continue to impact countries worldwide. At present, inadequate diagnosis and unreliable evaluation systems hinder the implementation and development of effective prevention and treatment strategies. Here, we conducted a horizontal and longitudinal study comparing the detection rates of SARS-CoV-2 nucleic acid in different types of samples collected from COVID-19 patients and SARS-CoV-2-infected monkeys. We also detected anti-SARS-CoV-2 antibodies in the above clinical and animal model samples to identify a reliable approach for the accurate diagnosis of SARS-CoV-2 infection. Results showed that, regardless of clinical symptoms, the highest detection levels of viral nucleic acid were found in sputum and tracheal brush samples, resulting in a high and stable diagnosis rate. Anti-SARS-CoV-2 immunoglobulin M (IgM) and G (IgG) antibodies were not detected in 6.90% of COVID-19 patients. Furthermore, integration of nucleic acid detection results from the various sample types did not improve the diagnosis rate. Moreover, dynamic changes in SARS-CoV-2 viral load were more obvious in sputum and tracheal brushes than in nasal and throat swabs. Thus, SARS-CoV-2 nucleic acid detection in sputum and tracheal brushes was the least affected by infection route, disease progression, and individual differences. Therefore, SARS-CoV-2 nucleic acid detection using lower respiratory tract samples alone is reliable for COVID-19 diagnosis and study.新型冠状病毒（SARS-CoV-2）及其造成的肺炎（COVID-19）持续严重影响世界各国。稳定可靠的诊断方法和评价系统的欠缺严重阻碍了有效预防和治疗策略的实施和发展。该研究通过横向和纵向研究，比较分析来源于COVID-19患者和SARS-CoV-2感染猴的不同类型样本中SARS-CoV-2的核酸检出率，分析COVID-19患者和SARS-CoV-2感染猴血清中抗SARS-CoV-2抗体的阳性率，以评估SARS-CoV-2感染诊断方法的可靠性。结果显示无论感染者的临床症状如何，痰液和气管刷样品中病毒核酸检出率较高，感染确诊率高，诊断结果稳定。而6.90% COVID-19患者血清中未检测到抗SARS-CoV-2免疫球蛋白M和G。此外，同时采集不同类型样本并结合其核酸检测的结果并不能提高诊断率。另外，与鼻拭子和咽拭子相比，痰和气管刷中SARS-CoV-2病毒载量持续时间较长，动态变化较明显。因此，痰和气管刷中SARS-CoV-2核酸检测受感染途径、疾病进展和个体差异的影响较小，用下呼吸道标本进行SARS-CoV-2核酸检测是SARS-CoV-2感染诊断和研究的可靠依据。.

Perovskite light emitting diodes (PeLEDs) have attracted considerable research attention because of their external quantum efficiency (EQE) of >20% and have potential scope for further improvement. However, compared to red and green PeLEDs, blue PeLEDs have not been extensively investigated, which limits their commercial applications in the fields of luminance and full-color displays. In this review, blue-PeLED-related research is categorized by the composition of perovskite. The main challenges and corresponding optimization strategies for perovskite films are summarized. Next, the novel strategies for the design of device structures of blue PeLEDs are reviewed from the perspective of transport layers and interfacial layers. Accordingly, future directions for blue PeLEDs are discussed. This review can be a guideline for optimizing perovskite film and device structure of blue PeLEDs, thereby enhancing their development and application scope.

With the rapid development of microelectronic devices, efficient thermal management in narrow spaces faces significant challenges. Two-phase heat transfer technology is proposed as a breakthrough in this field; however, big challenges, especially in designing a high-performance wick within limited space, are urgent to be addressed before ultrathin two-phase heat transfer devices (TPHTDs) can be further applied. In this study, a multilayer composite micromesh wick (MCMW), comprised of coarse and fine meshes with different layer combinations, is proposed to enhance the wicking capability, which is promising to further enhance the thermal performance of ultrathin TPHTDs. Capillary rise rate experiments are conducted to evaluate the comprehensive wicking capability. The results show that MCMW structures yield a significant wicking capability enhancement when compared with multilayer single mesh wick (MSMW) structures. The MCMW, consisted of 3 layers of 100-mesh and 3 layers of 300-mesh, exhibits an optimum volumetric flow rate of 14.44 mm3/s and an equilibrated wicking height at 55.98 mm. MCMW structure provides a convenient and effective alternative in enhancing the wicking capability of mesh wicks and the thermal performance of ultrathin TPHTDs.

In this study, we analyze the influence of the pore structure of an SBA-15 particle on the light emission from its inner adsorbed quantum dots (QDs) and outer light-emitting diode (LED) chips. It is found that the particle features of a high refractive index, comparable feature size of pore structure, and lower amount of QD adsorption help with QD light extraction, demonstrating a mechanism to suppress QD light propagating through pores and thus reducing the reabsorption loss. We consequently developed highly efficient QD white LEDs with wet-mixing QD/SBA-15 nanocomposite particles (NPs) by further optimizing the packaging methods and the introduced NP mass ratio. The LEDs demonstrated a record luminous efficacy (the ratio of luminous flux to electrical power) of 206.8 (entrusted test efficiency of 205.8 lm W-1 certificated by China National Accreditation Service) and 137.6 lm W-1 at 20 mA for white LEDs integrating only green QDs and green-red QD color convertors, respectively, with improved operating stability. These results are comparable to conventional phosphor-based white LEDs, which can be a starting point for white LEDs only using QDs as convertors toward commercialization in the near future.

Background A considerable portion of the elderly population are increasingly afflicted by degenerative spinal deformity (DSD), which seriously affects patient health-related quality of life (HRQoL). HRQoL index is used across many studies to show correlations between radio-graphical alignment, disability, and pain in patients with DSD. However, imaged structural deformity represents only one aspect for consideration, namely, the disability effect of DSD. We assessed the isokinetic strength of trunk muscle in patients with degenerative spinal deformity (DSD), and investigated its relationship with HRQoL. Methods In total, 38 patients with DSD (DSD group) and 32 healthy individuals (control group) were recruited. Both groups were homogeneous for age, weight, height and body mass index (BMI). Assessments were performed using the isokinetic dynamometer IsoMed-2000; trunk extensor, flexor strength and flexion/extension (F/E) ratios were explored concentrically at speeds of 30°, 60° and 120° per second. The grip strength of both hands was measured using a hand-held dynamometer. Visual analogue scale (VAS) scores, the Oswestry Disability Index (ODI), a Roland-Morris disability questionnaire (RDQ), and a 36-item Short Form Health Survey (SF-36) evaluated patient HRQoL. Correlations between trunk strength and HRQoL were analyzed. Results When compared with the control group, the DSD group showed lower trunk extensor strength at three velocity movements, and higher F/E ratios at 60° and 120°/s (p p > 0.05). In DSD group, trunk extensor strength at 60°/s was negatively associated with ODI and RDQ (p p p Conclusions We identified isolated trunk extensor myopathy in DSD, which causes an imbalance in trunk muscle strength. Isokinetic trunk extensor strength at 60°/s and trunk flexor strength at 120°/s can predict disability, and decrease physical HRQoL in DSD patients.

Retro filament white light-emitting diodes (WLEDs) have attracted great attention and are widely welcomed by consumers. The results of an investigation for the optical and thermal performance of filament-like WLEDs with various packaging structures are presented in detail. The optical simulation shows that the phosphor concentration on the chip-bonding side makes a great contribution to increasing backscattered blue light power. It means the backside should be packaged to improve blue light utilization. By controlling the phosphor coating structure, several filament-like LEDs were fabricated and subsequently investigated. The luminous efficacy (LE), correlated color temperature (CCT) and thermal reliability were measured, and then the structures were proposed and optimized. The optimal structure can maintain the equivalent LE compared with others under almost the same CCT. The CCT and light intensity spatial distribution were also analyzed based on the phosphor structure. The phosphor on the chip-bonding side contributes significantly to the CCT deviation. Consequently, the proposed structure filament-like WLEDs exhibited 2.23 and 5.42 ° lower working temperatures than the half packaging and full packaging structures under a driving current of 15 mA, respectively. Besides, the no-middle packaging structure was investigated in detail for optimal optical performance. After optimization, when the back surface dispensed $20~\mu \text{L}$ of phosphor resin, the LE increased from 182.9 to 188.3 lm/W at similar CCT with the CCT deviation changed from 1062 to 154.5 K significantly. Therefore, it was revealed that optimizing the packaging structure is an efficient method of enhancing the performance of filament-like WLEDs.

Near-ultraviolet light-emitting diodes (NUV-LEDs) are more likely to be commercially fabricated. The improvement of their wall-plug efficiency (WPE) by facial and effective methods has made a great impact. We propose a highly reflective boron nitride silicone (BN/silicone) layer to improve the light output power for NUV-LEDs. Our results show that increasing the BN concentration contributes to a higher UV-reflectivity of the BN/silicone layers. When the BN concentration increases from 0.5 to 15 wt%, the light output power enhancement increases gradually, thus achieving a maximum light output power enhancement of 46.2% for NUV-LEDs at a driving current of 350 mA compared with pure silicone encapsulation devices. This significant improvement is attributed to the increased UV-reflectance by the polymer-based lead-frame and packaging materials. Furthermore, the emission angle is decreased by 7.8° at a BN concentration of 15 wt% at 350 mA owing to the strong scattering ability of the BN/silicone layer. This provides more concentrated energy in lighting applications.

Even though chip-on-board light-emitting diodes (COB LEDs) with quantum dots (QDs) are attracting much attention for their high optical performance, their luminous efficiency (LE) is still low owing to total internal reflection. To overcome this problem, in this study, a microfiber-silicone hybrid (MFSH) structure is proposed to enhance the LE of QD-based COB LEDs. Polystyrene (PS) fiber films were fabricated by electrospinning and subjected to planar compression modeling to precisely control their film thickness. Subsequently, these films were coated with silicone to finish packaging the COB LEDs. Their diffuse reflectance of the MFSH structures before and after silicone resin encapsulation was analyzed, witnessing a diffuse reflectance at 450 nm of 97.7% when the pure fiber-film thickness increases to $220~\mu \text{m}$ . While applying to COB LEDs, the light output power of devices with MFSH structure increases first and then decreases, causing by the balance of light extraction by the scattering fiber and absorption by the difference between chip height and fiber film thickness. Finally, to increase the light-extraction capacity of COB LEDs, the thickness of the microfiber films was optimized to $25~\mu \text{m}$ at which their LE increased by 29.7% and 31.7% for the blue LED source and QD-based COB LED source, respectively. Therefore, the MFSH structure is an effective packaging method to produce highly efficient COB LEDs.

Miniaturized and flexible power resources such as supercapacitors with resistance of high voltage play a critical role as potential energy storage devices for implantable and portable electronics because of their convenience, high power density, and long-term stability. Herein, we propose a novel strategy for the fabrication of high voltage microsupercapacitors (HVMSCs) employing porous laser-induced graphene (from polyimide films with alkalization treatment) followed by laser carving of the polyvinyl alcohol/H3PO4 gel electrolyte to realize a series assembly of supercapacitors and significantly increase the voltage resistance. The results elucidated that HVMSCs (3 mm × 21.15 mm) exhibited excellent capacitive performance including exceptional potential window (10 V), high areal capacitance (244 μF/cm2), acceptable power density (274 μW/cm2) and energy density (3.22 μW h/cm2), good electrochemical stability and flexibility at different bending status (0, 45, 90, 135, and 180°), as well as impressive voltage durability more than 5 V in smaller scale (0.5 mm × 5.5 mm). As such, the HVMSCs have great potential to be integrated with microcircuit modules for the next-generation self-powered systems and storage electronic devices in high voltage applications.

The origin of overpressure and its effect on petroleum accumulation in the large Permian/Triassic conglomerate oil province in the Mahu Sag, Junggar Basin have been investigated based on comprehensive analysis of log curve combinations, loading-unloading curves, sonic velocity-density cross-plot, and porosity comparison data. The study results show that there are two kinds of normal compaction models in the study area, namely, two-stage linear model and exponent model; overpressure in the large conglomerate reservoirs including Lower Triassic Baikouquan Formation and Permian Upper and Lower Wu'erhe Formations is the result of pressure transfer, and the source of overpressure is the overpressure caused by hydrocarbon generation of Permian Fengcheng Formation major source rock. The petroleum migrated through faults under the driving of hydrocarbon generation overpressure into the reservoirs to accumulate, forming the Permian and Triassic overpressure oil and gas reservoirs. The occurrence and distribution of overpressure are controlled by the source rock maturity and strike-slip faults connecting the source rock and conglomerate reservoirs formed from Indosinian Movement to Himalayan Movement. As overpressure is the driving force for petroleum migration in the large Mahu oil province, the formation and distribution of petroleum reservoirs above the source rock in this area may have a close relationship with the occurrence of overpressure.

Objectives Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare subtype of non-small-cell lung cancer with no established treatment protocols. Immunotherapy is rarely used as a second-line choice in patients with advanced LELC, and more cases of this condition should be presented. Materials and methods We present a patient with advanced primary pulmonary LELC overcoming the resistance to second-line anti-programmed death-1 (PD-1) immunotherapy. We also review the literature to summarize the current immunotherapy landscape of this rare disorder. Results and conclusion The LELC patient progressed after first-line chemotherapy, was treated by immunotherapy alone and progressed again. To overcome the developed resistance to immunotherapy, chemotherapy with nedaplatin plus paclitaxel in addition to nivolumab was administered and a progression-free survival (PFS) of 5 months was achieved. It was also observed that the blood levels of neuron-specific enolase may act as an efficacy biomarker in LELC. Patients with this rare disorder resistant to anti-PD-1 immunotherapy might benefit from therapy based on PD-1 inhibition; this is a future avenue of research.

The quantum dot (QD)–phosphor hybrid structure is promising for efficient white light-emitting diodes (LEDs). In this article, separation packaging structures (SPSs) having green-QD and red-phosphor configurations for backlight displays are studied. The LEDs with green-QD-down and red-phosphor-down SPSs were achieved to have the same color coordinate (0.282, 0.257) which is a typical cool white color widely used in commercial backlighting. And the optical efficiency, device cost, and thermal performances of the LEDs are comprehensively analyzed. Results indicate that the green-QD-down SPS exhibits higher backscattered loss while less conversion loss. Therefore, the green-QD-down SPS has the same optical efficiency as another structure, owing to the balance between the backscattered loss and conversion loss. The concentration differences in these two structures were discussed combining with the device cost. Moreover, the green-QD-down SPS exhibits a better heat dissipation of QDs by reducing the heat path from QDs to the lead frame, as well as less thermal power generation in conversion layers. Consequently, the maximum (39.8 °C) and minimum (31.9 °C) temperatures of its inner QD layer are 7.7% and 20.3% lower than those of the red-phosphor-down SPS at an injection current of 100 mA.

The recently emerging laser-induced graphene (LIG) technology, with one-step processing and designable features, has been widely used in the fabrication of wearable/portable electronics. Herein, by taking inspiration from kirigami, we designed a stretchable supercapacitor (SC) step by step through controlling laser induction and cutting process on the polyimide (PI) film, with the use of one single CO2 laser source. Firstly, the carbonized basic geometric units of lines were produced on PI films to investigate the processing-structure relationships. Then, the complex photothermal conversion and heat transfer progress involved in the carbonized process were simulated by a photothermal model. Both experimental and theoretical results suggested that the laser power, scan rate and focus condition have great influence on the size, shape and morphology of the carbonized lines. Finally, we optimized the parameters of laser induction and cutting process to fabricate the kirigami-inspired SCs with reliable electrochemical properties and editable mechanical flexibility, showing great potential in the field of flexible electronics.

Quantum dots (QDs) have broad application prospects in displays such as full-color light-emitting diodes (LEDs) and micro-LEDs. However, an ultrahigh concentration of QDs is required to eliminate the pumping light for achieving high color purity, leading to significant reduction in the photoluminescence (PL) intensity of the QDs and the generation of much more heat. In this article, the PL intensity, thermal performance, and color purity of QD-LEDs were comprehensively improved by introducing a pumping-light absorber (PLA). Results indicate that the PLA packaging structure achieves a color purity that is similar to that of a conventional structure with ultrahigh QD concentration; the radiant power of blue light was reduced by 81.6% and this leads to a large shift in the color coordinates from (0.18, 0.26) to (0.20, 0.57). Moreover, the PLA packaging structure results in higher electroluminescence (EL) intensity and lower operating temperatures than the conventional structure. This is because of the higher color-conversion efficiency and partial transfer of thermal energy to the PLA layer. In particular, the EL intensity of the QD-LEDs increased by 25.1% and the steady-state temperature was reduced to 58.9 °C, which is 19.75% lower than that of a conventional structure (73.4 °C). In addition, the PLA packaging structure works equally well with ultraviolet (UV) pumping sources to achieve a higher color purity (enhancing the color gamut by 50.1% when using a 405-nm source).

The present study aimed to determine the characteristics of multifidus, erector spinae and psoas major degeneration in elderly patients with degenerative lumbar scoliosis (DLS) and the correlation between asymmetric changes and patient quality of life. A total of 49 patients with lumbar scoliosis (DLS group) and 38 healthy individuals (control group) were prospectively examined. The functional cross-sectional area, cross-sectional area difference index (CDI) and fat infiltration rate (FIR) of the multifidus, erector spinae and psoas major at the apical vertebral level were measured using MRI. The visual analogue scale (VAS) score, Oswestry Disability Index (ODI) and 36-item Short Form Health Survey (SF-36) score were used to evaluate patient quality of life. Correlations between the degree of asymmetric muscular degeneration and quality of life were analysed. The CDI of the multifidus, erector spinal and psoas major was higher in the DLS group compared with that in the control group. The CDI of the multifidus was found to be positively associated with the Cobb angle of lumbar scoliosis. Similar results were obtained for fat infiltration between the two groups. In addition, the CDI and FIR difference index of the multifidus was positively correlated with the VAS score and ODI but negatively correlated with the SF-36 score. The quality of life significantly decreased with increasing asymmetric atrophy and fat infiltration in the multifidus. Thus, strategies to enhance the function of the multifidus may have a positive impact on quality of life (Chinese Clinical Trial Registry, registration date, 2018.11.12; registration no. ChiCTR1800019459.).

Background: Studies have suggested that cognitive impairment in Alzheimer’s disease (AD) is associated with dendritic spine loss, especially in the hippocampus. Fluoxetine (FLX) has been shown to improve cognition in the early stage of AD and to be associated with diminishing synapse degeneration in the hippocampus. However, little is known about whether FLX affects the pathogenesis of AD in the middle-tolate stage and whether its effects are correlated with the amelioration of hippocampal dendritic dysfunction. Previously, it has been observed that FLX improves the spatial learning ability of middleaged APP/PS1 mice. Objective: In the present study, we further characterized the impact of FLX on dendritic spines in the hippocampus of middle-aged APP/PS1 mice. Results: It has been found that the numbers of dendritic spines in dentate gyrus (DG), CA1 and CA2/3 of hippocampus were significantly increased by FLX. Meanwhile, FLX effectively attenuated hyperphosphorylation of tau at Ser396 and elevated protein levels of postsynaptic density 95 (PSD-95) and synapsin-1 (SYN-1) in the hippocampus. Conclusion: These results indicated that the enhanced learning ability observed in FLX-treated middle-aged APP/PS1 mice might be associated with remarkable mitigation of hippocampal dendritic spine pathology by FLX and suggested that FLX might be explored as a new strategy for therapy of AD in the middle-to-late stage.

In this randomized retrospective study, 2 different endoscopic approaches were used to treat intractable plantar fasciitis with the aim to reduce complications and improve therapeutic effects. The lateral double incisions group included 23 feet in 22 patients, and the medial and lateral incisions group included 21 feet in 19 patients. Both groups were treated with endoscopy through the suprafascial approach. Patients were evaluated using the American Orthopaedic Foot and Ankle Society ankle-hindfoot scale (AOFAS-AHS) and visual analog scale (VAS) preoperatively and 3, 6, 12, and 24 months postoperatively. At the final follow-up, the Roles-Maudsley (R-M) score was used to determine patient satisfaction. The AOFAS-AHS scores of the lateral double incisions group were 54.54 ± 7.02 preoperatively and 97.71 ± 3.67 postoperatively. Similarly, AOFAS-AHS scores in the medial and lateral incisions group were 55.52 ± 6.41 preoperatively and 96.64 ± 3.18 postoperatively. There was no significant difference in AOFAS-AHS scores between groups before and after surgery. The time to full weightbearing after surgery and the time to return to full athletic activities in the 2 groups showed no significant difference. The postoperative VAS scores were significantly lower than the preoperative values for both groups. However, no differences were noted in VAS scores or R-M scores postoperatively between the 2 groups. In the medial and lateral incisions group, 3 cases of injury of the first branch of the lateral plantar nerve occurred postoperatively. In conclusion, both endoscopic approaches are effective in the treatment of intractable plantar fasciitis. The lateral double incisions approach showed a lower incidence of nerve injury.

The academic social networks (ASNs) play an important role in promoting scientific collaboration and innovation in academic society. Accompanying the tremendous growth of scholarly big data, finding suitable scholars on ASNs for collaboration has become more difficult. Different from friend recommendation in conventional social networks, scholar recommendation in ASNs usually involves different academic entities (e.g., scholars, scientific publications, and status updates) and various relationships (e.g., collaboration relationship between team members, citations, and co-authorships), which forms a complex heterogeneous academic network. Our goal is to recommend potential similar scholars for users in ASNs. In this article, we propose to design a graph embedding-based scholar recommendation system by leveraging academic auxiliary information. First, we construct enhanced ASNs by integrating two types of academic features extracted from scholars’ academic information with original network topology. Then, the refined feature representations of the scholars are obtained by a graph embedding framework, which helps the system measure the similarity between scholars based on their representation vectors. Finally, the system generates potential similar scholars for users in ASNs for the final recommendation. We evaluate the effectiveness of our model on five real-world datasets: SCHOLAT, Zhihu, APS, Yelp and Gowalla. The experimental results demonstrate that our model is effective and achieves promising improvements than the other competitive baselines.

In a microgravity field, the surface tension is dominant and the liquid restoring force is small. Therefore, the nonlinear large-amplitude liquid sloshing is even more likely to take place, which will negatively affect the attitude stability of the spacecraft. The numerical model for the liquid-filled coupling dynamics of spacecraft was established based on the Arbitrary Lagrangian-Eulerian finite element (ALE) method. The coupling effect is realized by exerting inertia forces to the liquid and sloshing forces and moments to the rigid body. The staggered algorithm is adopted to solve the liquid-sloshing module and the rigid body module in an iterative way. The numerical results of the rigid-liquid coupling system are compared with the analytical results, and the proposed methods in this dissertation are proved to be applicable and accurate. The high-order mode of the liquid is observed in the numerical simulations successfully during the rotation of the spacecraft. Meanwhile, the influences of the liquid sloshing on the coupling system are analyzed.

Porcine epidemic diarrhea virus (PEDV), as the main causative pathogen of viral diarrhea in pigs, has been reported to result in high morbidity and mortality in neonatal piglets and cause significant economic losses to the swine industry. Rapid diagnosis methods are essential for preventing outbreaks and transmission of this disease. In this study, a paper-based lateral flow immunoassay for the rapid diagnosis of PEDV in swine fecal samples was developed using stable color-rich latex beads as the label. Under optimal conditions, the newly developed latex bead-based lateral flow immunoassay (LBs-LFIA) attained a limit of detection (LOD) as low as 103.60 TCID50/mL and no cross-reactivity with other related swine viruses. To solve swine feces impurity interference, by adding a filtration unit design of LFIA without an additional pretreatment procedure, the LBs-LFIA gave good agreement (92.59%) with RT-PCR results in the analysis of clinical swine fecal samples (n = 108), which was more accurate than previously reported colloidal gold LFIA (74.07%) and fluorescent LFIA (86.67%). Moreover, LBs-LFIA showed sufficient accuracy (coefficient of variance [CV] 56 days) performance for PEDV detection, which is promising for on-site analysis and user-driven testing in pig production system.