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Locally harvested wild edible plants (WEPs) provide food as well as cash income for indigenous peoples and local communities, and they are of great importance in ensuring local food security. However, their uses and availability are poorly documented. This study aimed to enumerate WEP diversity and status of WEPs in a part of the Annapurna Conservation Area, Sikles region, where the population is dominated by the Gurung community. Ethnobotanical data were collected using guided field walks, semi-structured interviews, and field observation. The informant consensus method was employed and group discussions were conducted for triangulation of the information. Free listing and identification tests were performed to assess the knowledge of the informants. Both descriptive statistics and quantitative ethnobotanical methods were used for data analysis. A total of 72 wild food species belonging to 46 families and 61 genera were reported from the study area. Asparagaceae and Rosaceae were the dominant families, and herbs were the dominant life form. Fruits (34 species) were the most frequently used plant parts, followed by young shoots (16 species). Most edible plants were consumed in summer and during rainy seasons. While the age and type of informants had an influence on the number of enumerated plants, gender did not. Key informants and people aged 30–45 reported more species than other groups of respondents. Most of the knowledge about the use of WEPs was acquired from parents and relatives. The consumption of these plants was attributed to diversifying cuisine, spicing staple food, nutri-medicinal values, and cultural practices. People perceived the availability of WEPs to be gradually decreasing. However, WEPs are still abundant and diverse in the study area, and knowledge on their use is well-preserved. These resources provide food and nutrients to local people and can also be a source of cash income. Therefore, the documented information on WEPs may serve as baseline data for further studies on nutritional values and provide guidelines for safe collection. The results also revealed that many wild species are under growing pressure from various anthropogenic factors, suggesting effective community engagement is required for their conservation.

This study was conducted in the Kanda Area of Bajhang District, Kailash Sacred Landscape, Nepal. Inhabitants of the study areas have deep and extensive ethnobotanical knowledge on healthcare choices. They use plant resources on a wide scale to treat certain diseases, illnesses and ailments/conditions. Even though many resort to the local health post and to privately run pharmacies for allopathic medicines, the large majority use these in conjunction with household remedies made from local medicinal plants. Their uses are intertwined and interconnected. A small number resort to traditional healers, either alone or in conjunction with other medicinal practices. Shamanism is important part of traditional medicinal practices. Thus, important changes are taking place in perceptions and knowledge as well as the use of local plant resources. This study documented TK of remote villages in Far-Western Nepal.

Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.

Traditional knowledge and practices are increasingly recognized in the resource conservation and management practices, however are declining in many parts of the world including Nepal. Studies on the inventory of traditional knowledge are available, albeit limited, and empirical analysis of factors contributing to the decline of traditional knowledge are negligible in Nepal. We thus initiated this study in the Nepal part of the Kailash Sacred Landscape to (i) document traditional knowledge and practices on agriculture, forest-based herbal remedy, and genetic resource conservation; and (ii) identify factors contributing to the decline of traditional practices in the communities. Data was collected during September-December 2015 through key informant interviews, focus group discussions, and households survey. The household survey data was used in binary logistic regression analysis to identify factors contributing to the decline of six key traditional practices. The study documented 56 types of traditional practices. The regressions showed that the age of the respondent, distance to the nearest forest, distance to the nearest motorable road, family members' ill health, and seasonal migration of the household members for jobs significantly influencing to the decline of the particular traditional practices, however, their effects vary within a practice and among the practices. The use of modern medicine, increasing road linkages, decreasing trend of plant resource availability, and agriculture intensification are responsible for the decline of the particular traditional practices. We recommend to recognize their significance in the governing socio-ecological systems and to link the traditional and scientific knowledge systems through policy formulations.

The impacts of climate change in remote communities of the Himalaya have been relatively underexplored. This study combines traditional knowledge of people from three Village Development Committees (VDCs) of three districts of the high altitudinal regions in Nepal with scientific data to document the changes in climatic patterns, natural hazards, ecological systems and agricultural practices. The respondents perceived notable changes in the local climatic conditions, the frequency of natural disasters and ecological processes. Their perception of warming over the past 15–20 years parallels the increase in mean annual temperature recorded in the Thehe VDC of the Humla district, Tukuche VDC of the Mustang district and Lelep VDC of the Taplejung district from 1973 to 2012 by 0.02°C/year, 0.04°C/year and 0.01°C/year, respectively. Most respondents perceived an increase in the frequency of floods and landslides. The recorded average frequency of natural hazards including fire, flooding, landslide and avalanche...

The Kangchenjunga Landscape, an important repository of biodiversity, faces several challenges owing to various drivers of change. Human‒wildlife conflict (HWC) is one of such issue that transcends social, economic, environmental, as well as national and international borders among the three participating countries – Bhutan, India, and Nepal – making it a complex, transboundary issue. Based on the existing literature, earth observation data, and geographic information system, we used maximum entropy along with relevant environmental predictor variables to model and map HWC hotspots. The results suggested that about 19 per cent of the area within the landscape is at high risk of human‒wildlife conflict, with an anthropogenic factor ‒ distance to roads ‒ as the top predictor. Some protected areas are at higher risk than others. The Himalayan subtropical pine forest ecoregion is a high HWC zone (~63 per cent), followed by the Terai‒Duars savannah and grasslands ecoregion (~43 per cent). They also revealed that the low- and mid-elevation zones are prone to conflict due to greater forest fragmentation; patchy protected areas are disconnected from each other, and not big enough for large mammals like elephants and tigers. Human-wildlife conflict is observed to vary across different elevation and climate region of the landscape and highly correlated with forest fragmentation of the midhills. Hence, a holistic approach at the landscape level is needed for tackling human‒wildlife conflict. Connecting good habitats by restoring fragmented inter and intra-country areas would be an effective measure to mitigate human‒wildlife conflict.

Objective Chronic pain is more prevalent in indigenous populations who often prefer traditional remedies over allopathic drugs. Our objective was to investigate the traditional uses of medicinal plants from the Canadian boreal forest for the management of chronic pain syndromes. Methods We reviewed the most extensive database on medicinal plants used by aboriginal people of the Canadian boreal forest to investigate the plants used in the management of 3 of the most common chronic pain syndromes: arthritis/rheumatism; back pain; and headache/migraine. We also reviewed the pharmacology and phytochemistry literature to investigate concordance with indigenous knowledge. Results A total of 114 medicinal plant species were reported, of which 27 (23.5%) were used to treat more than 1 chronic pain syndrome. Pharmacological or phytochemical evidence to explain plant function as chronic pain remedy was available in the literature for only 38 species (33%), with several species reported to have anti-inflammatory and analgesic properties effective in treating chronic pain syndromes. Conclusions Our study showed the potential of boreal plants as alternative and complementary medicines for the treatment of chronic pain syndromes that could be enhanced by further research on efficacy and safety issues.

People's livelihood in several Himalayan regions largely depends on collection, use, and trade of medicinal plants. Traditional use is generally not a problem, but commercial gathering of selected species to meet increasing national and international demand can result in over-exploitation. Sustainable management of medicinal plants requires a clear understanding of the respective roles, responsibilities and viewpoints of the various stakeholders involved. Through personal interviews and group discussions, this study aimed at investigating the views of two stakeholder groups on use, trade and conservation of medicinal plants in the Rasuwa district of Nepal. Local people and district and national organizations agreed that medicinal plants are collected for a combination of commercial and personal uses. Perceptions on market availability differed significantly: 100 % of the respondents from district and national organizations saw markets as easily available, against only 36 % for local people. This could explain why medicinal plants were perceived by local people to contribute less to income generation than to livelihood improvement. Different viewpoints were also expressed concerning the status of medicinal plants in the district: 81 % of the respondents from district and national organizations considered that medicinal plants were threatened, compared to only 28 % for local people. Despite this disparity, both stakeholder groups agreed upon potential threats to medicinal plants: over-harvesting; habitat loss due to land-use change and deforestation; and over-grazing by livestock. Several challenges were identified regarding sustainable management of medicinal plants, such as ambiguous policies; lack of resources, information and infrastructures; habitat degradation; and over-exploitation. Despite these challenges, respondents agreed that the medicinal plants sector offers huge opportunities in the Rasuwa district, given resource availability, community awareness and motivation, and the priority given to the sector by governments and other agencies. Proper collaboration, communication and coordination among stakeholders are needed to grab these opportunities.

A survey of plant biodiversity and ethnobotany was conducted along the Seti river banks in the Tanahun district of Western Nepal. This area, home of the Magar ethnic group, will be impacted by a major hydropower project, currently under feasibility study. The objective of the study was to document plant biodiversity and ethnobotany in order to suggest appropriate conservation and management strategies. Botanical sampling was conducted inside quadrats and along transects. A total of 221 plant species were recorded in the study area, distributed as herbs (80 species), trees (68), shrubs (28), climbers (19), pteridophytes (18), lianas (5), and epiphytes (3). Twelve of the inventoried species figure in one or more conservation categories identified by various national or international agencies. Group discussions and personal interviews allowed to find out that 43% of the species were ethnobotanically important for the local people and that most were used as medicine, food, or timber. We propose specific species for sustainable use programs based on certain criteria. The area is very important in terms of plant biodiversity and ethnobotany, and hence, immediate implementation of conservation measures is recommended to maintain the high social, ecological and economic values of the area.

This article scopes the status and potential of non-timber forest products (NTFPs) in community forests and the national forest of Bardiya district in western Nepal. The human ecological approach, participatory rural appraisal, focus group discussions and interviews were used to gather data and information for analysis. The results of the data analysis indicate that the area harbours a high diversity of potential NTFPs. Altogether, 101 species and their traditional uses were recorded. The NTFP species are clustered into first, second, third and fourth categories on the basis of their market value and resource availability. Despite a gradual but systematic socio-cultural transformation of the local communities, they still possess ample knowledge of plants and their uses. It is observed that the proper management of the NTFPs could play a vital role in the improvement of people's livelihood on a sustainable basis.

Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research.

Non-timber Forest Products (NTFPs), an important provisioning ecosystem services, are recognized for their contribution in rural livelihoods and forest conservation. Effective management through sustainable harvesting and market driven commercialization are two contrasting aspects that are bringing challenges in development of NTFPs sector. Identifying potential species having market value, conducting value chain analyses, and sustainable management of NTFPs need analysis of their use patterns by communities and trends at a regional scale. We analyzed use patterns, trends, and challenges in traditional use and management of NTFPs in the southern slope of Kangchenjunga Landscape, Eastern Himalaya and discussed potential implications for conservation and livelihoods. A total of 739 species of NTFPs used by the local people of Kangchenjunga Landscape were reported in the reviewed literature. Of these, the highest number of NTFPs was documented from India (377 species), followed by Nepal (363) and Bhutan (245). Though the reported species were used for 24 different purposes, medicinal and edible plants were the most frequently used NTFP categories in the landscape. Medicinal plants were used in 27 major ailment categories, with the highest number of species being used for gastro-intestinal disorders. Though the Kangchenjunga Landscape harbors many potential NTFPs, trade of NTFPs was found to be nominal indicating lack of commercialization due to limited market information. We found that the unsustainable harvesting and lack of marketing were the major constraints for sustainable management of NTFPs sector in the landscape despite of promising policy provisions. We suggest sustainable harvesting practices, value addition at local level, and marketing for promotion of NTFPs in the Kangchenjunga Landscape for income generation and livelihood improvement that subsequently contributes to conservation.