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A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. It is imperative to discover effective therapies to overcome drug resistance and improve clinical outcomes. We have developed a novel class of silicon-containing compounds and evaluated the anticancer activities and mechanism of action using cellular and animal models of drug-resistant PCa. Five organosilicon compounds were evaluated for their anticancer activities in the NCI-60 panel and established drug-resistant PCa cell lines. GH1504 exhibited potent in vitro cytotoxicity in a broad spectrum of human cancer cells, including PCa cells refractory to ADT and chemotherapy. Molecular studies identified several potential targets of GH1504, most notably androgen receptor (AR), AR variant 7 (AR-v7) and survivin. Mechanistically, GH1504 may promote the protein turnover of AR, AR-v7 and survivin, thereby inducing apoptosis in ADT-resistant and chemoresistant PCa cells. Animal studies demonstrated that GH1504 effectively inhibited the in vivo growth of ADT-resistant CWR22Rv1 and chemoresistant C4-2B-TaxR xenografts in subcutaneous and intraosseous models. These preclinical results indicated that GH1504 is a promising lead that can be further developed as a novel therapy for drug-resistant PCa.

Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. It is an aggressive tumor with a tendency to spread to the lung, which is the most common site of metastasis. Patients with advanced OS with metastases have poor prognoses despite the application of chemotherapy, thus highlighting the need for novel therapeutic targets. The tumor microenvironment (TME) of OS is confirmed to be essential for and supportive of tumor growth and dissemination. The immune component of the OS microenvironment is mainly composed of tumor-associated macrophages (TAMs). In OS, TAMs promote tumor growth and angiogenesis and upregulate the cancer stem cell-like phenotype. However, TAMs inhibit the metastasis of OS. Therefore, much attention has been paid to investigating the mechanism of TAMs in OS development and the progression of immunotherapy for OS. In this article, we aim to summarize the roles of TAMs in OS and the major findings on the application of TAMs in OS treatment.

To effectively evaluate the level of economic security of water resources (WES) in China and analyze its influencing factors, a comprehensive evaluation model of WES and a regression analysis model of influencing factors are established based on the panel data of 30 provinces in China from 2011 to 2017. It is found that, first, WES in China presents a fluctuating upward trend. Second, different regions have different economic security levels for their water resources in China, among which WES in the central region is the highest. Third, there is a U-shaped correlation between economic development and WES, and the population, pollution control level, technological innovation have negative impacts on WES. Moreover, this study also finds that with upgrades to the industrial structure and level of human capital, there will be improvements to WES. However, the external coefficient and the investment scale of fixed assets have a negative impact on the economic security of water resources. This is helpful to utilize the water resources, and improve the water resources safety management.

BACKGROUND AND PURPOSE To compare and characterize metabolic features of high- and low-grade glioma tumors using 68 Ga-PSMA-617 and 18 F-FDG positron emission tomography/computed tomography (PET/CT). METHODS Thirty patients who underwent both 68 Ga-PSMA-617 and 18 F-FDG PET/CT over 2 consecutive days and then underwent surgical treatment were retrospectively identified. All tumors were diagnosed histologically. This report includes 16 high-grade glioma (HGG) and 14 low-grade glioma (LGG) tumors. Standard uptake value (SUV) and target to nontarget (T/NT) were quantitatively investigated through the entire tumor region. Statistical analyses were performed using area under the curve (AUC) and comparison of two means. RESULTS SUVmax and SUVmean were the most effective (AUC, 0.96 and 0.94 for PSMA PET; AUC, 0.79 and 0.74 for FDG PET, respectively) for differentiating HGGs from LGGs. These methods distinguished between HGG and LGG effectively (PSMA PET: SUVmax , 5.766 ± 3.945 vs. 0.7364 ± 0.5295, p < 0.0001; SUVmean , 1.666 ± 1.680 and 0.1514 ± 0.1534, p < 0.0001, respectively) (FDG PET: SUVmax , 11.67 ± 3.639 and 9.118 ± 6.612; SUVmean , 5.648 ± 2.114 and 4.435 ± 2.872; p = 0.0083, 0.0262, respectively). The Youden index for SUVmax and SUVmean of 68 Ga-PSMA-617 and 18 F-FDG were 0.82 and 0.79 and 0.54 and 0.61, separately. T/NTmax was helpful for visual inspection of 68 Ga-PSMA-617-PET images (T/NTmax : 1.291 ± 0.9553 in grade II, 5.25 ± 2.435 in grade III, and 13.61 ± 13.84 in grade IV). T/NTmax differed significantly between LGG and HGG and between subtypes of LGG. CONCLUSION PET/CT with 68 Ga-PSMA-617 and 18 F-FDG may help distinguish between HGG and LGG, and 68 Ga-PSMA-617 PET/CT is superior to18 F-FDG in differentiating HGG and LGG.

Curved twin I-girder composite bridge (TGCB) is becoming popular in Chinese highway bridge building. To study its ultimate bearing behavior, in this paper, one 1 : 5 scale intact model of a two-span curved continuous TGCB was tested to failure to evaluate its safety reserve and ductility. Afterwards, based on the experimental result, 3D FE models were developed and validated. At last, using the validated 3D FE models, the effect of construction scheme, radius of curvature, yield strength of steel, concrete compressive strength, crossbeams, and bottom lateral bracings on the ultimate bearing capacity were examined. The experimental results showed that the ultimate load (Pu) is approximate 13.6 times the service equivalent load. The cracking load and yielding load are approximately 0.12 and 0.47 Pu, respectively. The ductility coefficients are 4.06∼4.40. These above may indicate that the TGCB designed according to Chinese codes has good safety reserve and ductility. From parameter analysis results, it was concluded that the TGCB with full-support construction scheme has larger yield load and ultimate load compared with the one with erecting machine construction scheme. On the other hand, the ultimate bearing capacity reduces nonlinearly with the increase of curvature. Besides, the yield strength of steel, crossbeams, and bottom lateral bracings has a significant effect on the ultimate bearing capacity of curved TGCB. And the smaller the radius of curvature, the more obvious the effect of the latter two factors is. Unfortunately, it is unwise to continuous to improve the ultimate load by increasing the grade of steel for the TGCB when steel grade exceeds Q390. Moreover, in consideration of the big difference in bearing capacity between the inner girder and outer girder of the TGCB with small radius of curvature as well as the economy, it is suggested that the inner and outer steel girders of that TGCB should be designed differently.

In China, the traditional biomass, coal, and other highly polluting energy sources used by rural households have had many negative effects on the environment and the health of residents. To explore the influencing factors of energy consumption choices in rural household cooking and heating in China and to promote more modern, efficient, and clean energy consumption modes for rural household cooking and heating, this article builds a multinomial logit model for theoretical analysis based on interview and survey data in rural areas of central and eastern China from January to February 2017. The results show that (1) biomass energy still occupies an important position in the life of Chinese rural households; (2) the driving factors for the cooking and heating energy choices of rural residents in central and eastern China include the number of appliances, family type, family members' leisure, heating demand, and natural endowment; and (3) because of the above main influencing factors, some policies that conform to the background of the times, such as household appliances upgrade policies and centralized housing policies, are worthy of government consideration.

BACKGROUND Gastrointestinal stromal tumor (GIST) usually originates in the stomach, followed by the small intestine, rectum, and other parts of the gastrointestinal tract. The most common sites of metastasis are the liver and peritoneum, whereas spinal metastases from GIST are extremely rare. CASE SUMMARY We found a case of GIST with the first presentation of multilevel spinal metastases involving the thoracic and lumbar vertebrae. A 61-year-old Chinese man presented to our clinic because of pain in his lower back and hip for 10 d without cause. Subsequently, computed tomography (CT) and magnetic resonance imaging (MRI) revealed abnormal signals in the vertebral appendages of T12 and L4 accompanied by spinal canal stenosis, which was considered as tumor metastasis. As there were no metastases to vital organs, posterior thoracic and lumbar spinal decompression + adnexal mass resection + pedicle internal fixation was adopted to achieve local cure and prevent nerve compression. The results of histopathological studies were consistent with the metastasis of GIST. No local recurrence or new metastases were found at the 6-mo follow-up at the surgical site. The patient has no neurological symptoms at present. It is worth mentioning that a rectal mass was found and surgically removed 1 mo after the patient was discharged from hospital, and the pathological diagnosis of the mass was GIST. CONCLUSION By reviewing 26 previously reported cases of spinal metastasis in GIST, it was found that spinal metastasis of GIST has become more common in recent years, so the possibility of early spinal metastasis should be recognized. CT and MRI are of great value in the diagnosis of spinal metastatic tumors, and pathological biopsy is the gold standard for the diagnosis of metastatic tumors. It is safe and feasible to treat isolated spinal metastasis in GIST by excising metastatic masses, decompressing the spinal canal, and stabilizing the spine.

Objective This retrospective study was purposed to evaluate epidemiological, clinical, and 3D radiological features of supernumerary teeth (ST) in a non-syndromic Chinese children and adolescent dental population. Materials and methods Original cone-beam CT (CBCT) data from 18,861 patients aged from 6 to 17 years with dental maxillofacial diseases treated in a Chinese dental hospital from June 2012 to December 2018 were utilized to screen patients with ST. Diagnosis and characterizations of ST were analyzed by CBCT coupled with 3D reconstruction. All relevant epidemiological, clinical, and radiographic details about ST were collected and statistically analyzed. Results Among total 18,861 patients, 2,768 ST were identified in 1984 subjects with a prevalence of 10.52% and a male:female ratio of 1.86:1. Majority of ST were single, conical, inverted, impacted, and located in maxilla anterior region. ST-associated complications mainly included malposition, rotation, and impaction of adjacent teeth, which were notably associated with morphology and position of ST. Conclusion The prevalence of ST in Chinese children and adolescent dental population was 10.52% and tended to present as single, conical, inverted, and impacted, which resulted in abnormalities of neighboring teeth. Our outcomes are beneficial for clinicians to more comprehensively understand the incidence, characterization, and clinical treatment planning of ST in dental children and adolescents.

This article developed a novel numerical model for accurately predicting the thermal performance of fin-and-tube condenser, which coupled heat transfer between the air and refrigerant side. The hea...

Human copper transporter 1 (CTR1) has been proven to be overexpressed in many types of cancer cells, and copper (II)-64 chloride (64CuCl2) has been used as an effective tracer for positron emission tomography (PET) imaging in tumor-bearing animal models. Thus, this study aimed to investigate the potential application of 64CuCl2 in PET imaging of lung cancer through targeting CTR1. The expression of CTR1 in a series of lung cancer cell lines was identified by quantitative real-time polymerase chain reaction (Q-PCR), western blot, enzyme-linked immunosorbnent assay (ELISA), and immunofluorescent staining. Then in vitro cell uptake assay of 64CuCl2 was investigated in human lung cancer cell lines with different levels of CTR1 expression. Small animal PET imaging and quantitative analysis were performed in human lung cancer tumor-bearing mice after intravenous injection of 64CuCl2, respectively. The CTR1 expression in multiple human lung cancer cells was identified and confirmed, and H1299 cell lines with high CTR1 expression, H460 with moderate CTR1, and H1703 with low CTR1 were selected for further experiments. In vitro cellular uptake assay displayed that the 64CuCl2 uptake by these three kinds of cells was positively correlated with their CTR1 expressed levels. The blocking experiments testified the specificity of 64CuCl2 to target CTR1. Moreover, small animal PET imaging and quantitative results showed that 64CuCl2 accumulation in H1299, H460, and H1703 tumor-bearing mice were consistent with CTR1 levels and cell uptake experiments. The expression of CTR1 in human lung cancer xenograft model could be successfully visualized by 64CuCl2 PET examination. With the expected growth of PET/CT examination to be an essential strategy in clinical lung cancer management, 64CuCl2 has the potential to be a promising PET imaging agent of lung cancer.

This study was aimed to delineate the prevalence, clinical, and 3-dimentional radiographic characteristics of adult supernumerary teeth (ST found) in a Chinese non-syndromic, dental population. Medical records and cone beam computed tomography (CBCT) images were utilized to identify adult patients with ST in a tertiary referral dental hospital between June 2012 and December 2018. CBCT scan coupled with 3-dimentional reconstruction was used to characterize the detailed location, morphology, orientation of ST, and their relationship with adjacent teeth and neighboring structures. All relevant information regarding age and gender of patients, morphology, and 3-dimentional topography of ST as well as ST-associated complications were recorded and statistically analyzed. A total number of 1149 ST was identified in 921 eligible patients screened from 60,104 subjects with the prevalence of 1.5%. Male patients outnumbered females with a gender ratio of 1.76:1. The majority of ST was single, located in the maxilla, especially the maxillary central incisor region. Most ST were conical shape, inverted orientation, and impacted. ST-associated complications including impaction or root resorption of adjacent teeth, and cystic/tumor-like lesions were totally found in 13% ST and significantly associated with location, orientation, and morphology of ST. Most ST in Chinese adults were conical, inverted, impacted, and located in the maxillary central incisor region, and associated with various complications. Our findings offer valuable information concerning the prevalence, clinical, and radiographic characteristics of ST in non-syndromic Chinese adults. These findings are beneficial for clinicians to comprehensively understand the incidence, pathogenesis, and clinical management of ST.

Magnetic hyperthermia (MH) has been introduced clinically as an alternative approach for the focal treatment of tumors. MH utilizes the heat generated by the magnetic nanoparticles (MNPs) when subjected to an alternating magnetic field (AMF). It has become an important topic in the nanomedical field due to their multitudes of advantages towards effective antitumor therapy such as high biosafety, deep tissue penetration, and targeted selective tumor killing. However, in order for MH to progress and to realize its paramount potential as an alternative choice for cancer treatment, tremendous challenges have to be overcome. Thus, the efficiency of MH therapy needs enhancement. In its recent 60-year of history, the field of MH has focused primarily on heating using MNPs for therapeutic applications. Increasing the thermal conversion efficiency of MNPs is the fundamental strategy for improving therapeutic efficacy. Recently, emerging experimental evidence indicates that MNPs-MH produces nano-scale heat effects without macroscopic temperature rise. A deep understanding of the effect of this localized induction heat for the destruction of subcellular/cellular structures further supports the efficacy of MH in improving therapeutic therapy. In this review, the currently available strategies for improving the antitumor therapeutic efficacy of MNPs-MH will be discussed. Firstly, the recent advancements in engineering MNP size, composition, shape, and surface to significantly improve their energy dissipation rates will be explored. Secondly, the latest studies depicting the effect of local induction heat for selectively disrupting cells/intracellular structures will be examined. Thirdly, strategies to enhance the therapeutics by combining MH therapy with chemotherapy, radiotherapy, immunotherapy, photothermal/photodynamic therapy (PDT), and gene therapy will be reviewed. Lastly, the prospect and significant challenges in MH-based antitumor therapy will be discussed. This review is to provide a comprehensive understanding of MH for improving antitumor therapeutic efficacy, which would be of utmost benefit towards guiding the users and for the future development of MNPs-MH towards successful application in medicine.

Metabolic dysfunction (MD) is a major health problem threatening the life quality of menopausal women. Saffron has been widely used in herb prescriptions for treating menopausal syndrome. However, the pharmacological effects and mechanisms of saffron are poorly understood. Here, we investigated the effect of crocin, the major ingredient of saffron and its active metabolite in blood, crocetin, on MD and lipid metabolism in ovariectomized (OVX) mice and 3T3-L1 adipocytes. The present study showed that intragastric treatment of crocin prevented weight gain, fat accumulation, and insulin resistance in OVX mice by increasing energy expenditure and fat oxidation. Mechanistically, crocin influenced adipose tissue homeostasis by regulating adipogenic and lipolytic factors, which was strongly associated with the restoration of the downregulated ERβ function in white adipose tissue (WAT). In vitro, crocetin facilitated lipid metabolism in an ERβ-dependent manner. Our results demonstrated the beneficial effects of crocetin/crocin-mediated intervention against metabolic dysfunction, revealing a prospective therapeutic application in menopausal women.

Background: Social media is used as a new channel for health information. In China, the official WeChat account is becoming the most popular platform for health information dissemination, which has created a good opportunity for the Centers for Disease Control and Prevention to facilitate health information online to improve emergency public health literacy.Methods: Data were collected from the Guangzhou CDC i-Health official WeChat account between April 1, 2018 and April 30, 2019. Descriptive analysis was performed for basic information about the followers and posts of the official WeChat account. Multiple logistic regression analysis was used to analyze the association among various factors of posts on engagement of followers of the official WeChat account.Results: Among 187,033 followers, the total numbers of post views, shares, likes, add to favorites, and comments for 213 posts were 1,147,308, 8,4671, and 5,535, respectively. Engagement of followers peaked on the dissemination date and gradually declined. The main post topics were health education posts and original posts. In the multiple logistic regression model, the number of post views was found to be significantly associated with infectious disease posts (AOR: 3.20, 95% CI: 1.16–8.81), original posts (AOR: 10.20, 95% CI: 1.17–89.28), and posts with title-reflected content (AOR: 2.93, 95% CI: 1.16–8.81).Conclusion: Our findings facilitate the government to formulate better strategies and improve the effectiveness of public information dissemination.

This paper studies the potential application of ventilation systems with thermal energy storage (TES) using phase change materials (PCMs) for space cooling in air conditioned buildings during the summer. A south-facing middle office room located in Beijing, China is considered for study. To simulate the indoor thermal environment and energy consumption of the room, a dynamic computational model which consists of a building thermal model, a heat transfer model of a TES unit and the performance curve of an air conditioner (AC) is built and validated. The time lag to switch on AC, the cooling energy provided by AC, PCMs and structure elements, the runtime of AC and fan, and the overall electricity energy consumption of the TES system are calculated and compared to a base case without night ventilation (NV) and a case with conventional NV system. The results indicate that the higher the indoor temperature set point, the higher the cooling energy contributions of PCMs and structure elements and therefore the higher the potential application of the TES system. The electricity energy saving ratio (ESR) by using the TES system over the base case is found to be 16.9%–50.8%, while that against the conventional NV system is 9.2%–33.6%.

Objectives Avian influenza viruses (AIVs) poise significant risk to human health and the poultry industry. We evaluated the transmission risk along the poultry supply chain. Methods During October 2015 and July 2016, four rounds of cross-sectional surveys were performed to characterize AIV spread in farms, transport vehicles, slaughterhouses, wholesale and retail live poultry markets (LPMs). Poultry cloacal and oral swabs, environmental swabs, bioaerosol samples and human sera were collected. Poultry and environmental samples were tested for AIVs by rRT-PCR, further subtyped by next generation sequencing. Previous human H9N2 infections were identified by hemagglutination inhibition and microneutralization tests. Logistic regression was fitted to compare AIV transmission risk in different settings. Results AIVs was detected in 23.9% (424/1771) of the poultry and environmental samples. AIV detection rates in farms, transport vehicles, wholesale and retail LPMs were 4.5%, 11.1%, 30.3% and 51.2%, respectively. 5.2%, 8.3% and 12.8% of the poultry workers were seropositive in farms, wholesale and retail LPMs, respectively. The regression analysis showed that virus detection and transmission risk to human increased progressively along the poultry supply chain. Conclusions Strengthening control measures at every level along the poultry supply chain, using a one health approach, is crucial to control AIV circulation.

Ventilation system with thermal energy storage (TES) using phase change materials (PCMs) can be employed to save energy in buildings, which stores outdoor coldness in the PCMs at night and releases this energy to cool down the fresh ventilation air during the daytime. However, its performance depends on the design parameters. This paper presents a detailed parametric analysis to address the separate effect of each design parameter on the cooling energy supply and net electricity saving of the TES system against a conventional ventilation system for the climate of Beijing, by using a computational heat transfer model. A genetic algorithm (GA) is used to optimize the design parameters for maximizing the net electricity saving in four cities of China. The decision variables are related to the PCM melting temperature, PCM slab thickness and cold charging airflow rate. The results show that the saving-optimal solution is not unique and depends on the climate. GA optimization increases the net electricity saving by 10%–54%, with a mean value of 31%. Sensitivity analysis of net electricity saving to the above three variables is carried out. Likewise, the sensitivity of each variable is not unique and depends on the climate.

Background Evaluation of the clinical efficacy of percutaneous pedicle screw fixation (PPSF) combined with percutaneous vertebroplasty (PVP) in the treatment of thoracic and lumbar metastatic tumor.Methods 20 patients with thoracic and lumbar metastatic tumor were treated with PPSF combined with PVP and followed up 6–25 months. Using the visual analog scale (VAS) and the Barthel Index of Activities of Daily Living (BIADL) to evaluate pain intensity and quality of life before surgery and at 7 days, 3 months, 6 months after treatment.Results In this study, a total of 20 patients were followed up for 6–25 months (mean time was 14.10 months). The VAS scores of all patients were significantly decreased, while the BIADL scores were significantly increased. No patients suffered from complications such as infection, pedicle screw loosening or PMMA oozing. Spine stability was observed in all the surviving patients during the follow-up.Conclusions PPSF combined with PVP is a potentially viable treatment for thoracolumbar metastases in patients with poor systemic condition or patients who refuse to undergo a conventional open procedure such as en bloc corpectomy, and in the presence of vertebral instability or pathological fracture without significant spinal compression.

Objective: The purpose of this study was to explore the value of 18F-FDG PET/CT in monitoring the disease activity and predicting the prognosis of the Adult-onset Still's disease (AOSD).Methods: We retrospectively analyzed the electronic medical records of 45 AOSD patients who underwent 18F-FDG PET/CT in the Second Xiangya Hospital. PET/CT imaging and clinical information were retrospectively reviewed and analyzed. 18F-FDG uptake was assessed by measuring standard uptake value (SUV) in the spleen, liver, bone marrow, and lymph nodes. The spleen-to-liver ratio of the SUVmax (SLRmax) and SUVmean (SLRmean), the bone-to-liver ratio of the SUVmax (BLRmax), and SUVmean (BLRmean), and the lymph nodes-to-liver ratio of the SUVmax (LyLRmax) were calculated. Clinical and laboratory information were collected and evaluated for association with metabolic parameters of 18F-FDG PET/CT. The influencing factors for recurrence within 1 year were analyzed to determine whether 18F-FDG PET/CT can predict the prognosis of AOSD patients.Results: Elevated 18F-FDG uptake could be observed in bone marrow, spleen, and lymph nodes of AOSD patients. Correlation analysis between 18F-FDG uptake of organs and laboratory examinations showed that SLRmean positively correlated with LDH, AST, ferritin, and the systemic score (r = 0.572, 0.353, 0.586, and 0.424, P < 0.05). The SLRmean had the highest correlation with ferritin (r = 0586, P < 0.001). All metabolic parameters in spleen, including SUVmax, SUVmean, SLRmax, and SLRmean, are positively correlated with LDH level (r = 0.405, 0.539, 0.481, and 0.572, P < 0.05). Bone marrow SUVmax, BLRmax, and BLRmean were correlated with C-reactive protein (CRP) level (r = 0.395, 0.437, and 0.469, P < 0.05). Analysis of the influencing factors of recurrence within 1 year showed that the spleen SUVmax, spleen SUVmean, SLRmax, SLRmean, ferritin, and the systemic score of the recurrence group was significantly higher than the non-recurrence group (P < 0.05). The SLRmean cutoff of 1.66 with a sensitivity of 72.7% and specificity of 80.0% had the highest performance in predicting recurrence.Conclusion: The glucose metabolism of the liver, spleen, and bone marrow of AOSD patients were correlated with laboratory inflammatory indicators and system score, suggesting that 18F-FDG PET/CT could be applied to evaluate disease activity. Moreover, spleen 18F-FDG uptake may be a potential biomarker for predicting clinical prognosis of AOSD patients.

Purpose The purpose of this paper is to analyze the impact of the off-office audit of natural resource assets on the prevention and control of water pollution against a background of big data using a differences-in-differences model. Design/methodology/approach This study constructs a differences-in-differences model to evaluate the policy effects of off-office audit based on panel data from 11 cities in Anhui Province, China, from 2011 to 2017, and analyzes the dynamic effect of the audit and intermediary effect of industrial structure. Findings The implementation of the audit system can effectively reduce water pollution. Dynamic effect analysis showed that the audit policy can not only improve the quality of water resources but can also have a cumulative effect over time. That is, the prevention and control effect on water pollution is getting stronger and stronger. The results of the robustness test verified the effectiveness of water pollution prevention and control. However, the results of the influence mechanism analysis showed that the mediating effect of the industrial structure was not obvious in the short term. Practical implications These findings shed light on the effect of the off-office audit of natural resource assets on the prevention and control of water pollution, and provide a theoretical basis for the formulation of relevant environmental policies. Furthermore, these findings show that the implementation of the audit system can effectively reduce water pollution, which has practical significance for the sustainable development of China's economy against the background of big data. Originality/value This study quantitatively analyzes the policy effect of off-office auditing from the perspective of water resources based on a big data background, which differs from the existing research that mainly focuses on basic theoretical analysis.

With the rapid increase of downward pressure on China’s economy, the stability of the property market, as an important part of the economic transformation process, also has a far-reaching impact on enterprises’ R&D investment. We select the data of Chinese large and medium-sized industrial enterprises from 1998 to 2015 as our research sample and propose a new combination measurement model based on closeness degree to measure the real estate bubble level in China accurately. The structural vector autoregressive (SVAR) theory is utilized to empirically test the dynamic relationship between the real estate bubble, corporate liquidity, and R&D investment. The results indicate that the real estate bubble level in China is increasing, and a certain risk of deviating from the safety interval in the future exists; The rapid expansion of the real estate bubble has a continuing negative impact on corporate R&D investment, that is, its "credit mitigation effect" is much smaller than the "capital relocation effect," and industrial enterprises will fall into the so-called "low-tech lock-in" state. In other words, to a certain extent, the development of this kind of real estate bubble will not be conducive to the transformation and upgradation of enterprises and long-term economic growth.

OBJECTIVE: To determine the duration of SARS-CoV-2 persistence in quarantine hotel environments. METHODS: 39 Patients confirmed by RT-PCR were included. We collected clinical features, laboratory test results, smear sample information, and quarantine room information. Genome sequencing and phylogenetic analysis were conducted. We analyzed the factors associated with environmental contamination. RESULT: Among 39 COVID-19 cases, 10 were asymptomatic and 37 were imported from aboard. We collected 271 swab samples from environmental surfaces related to observational patients. Eighteen swab samples from seven patients were positive. The highest contamination rates occurred on cups (100%), followed by hand sink (12.82%), toilet seat and flush (7.89%), telephone (5.56%), bedside table (5.56%), and floor drain (5.41%). The results showed that environmental surface contamination was associated with the clinical cycle threshold values for patients (P = 0.01) and the sampling interval time after the cases left their rooms (P = 0.03). The duration of environmental surface contamination was associated with the wet status of the sampling site (P = 0.01). CONCLUSION: Our findings showed that environmental contamination might be attributed to the viral load in the respiratory tracts of patients and the sampling interval time after the cases left their rooms. Moist surfaces were more vulnerable to remaining SARS-CoV-2 RNA-positive. Our study highlights the importance of implementing strict chemical disinfection strategies in quarantine rooms.

Green credit policy is an innovative measure in the financial industry and can help enterprises reduce energy consumption, reverse the situation of environmental pollution and resource waste, and promote sustainable development of the economy and society based on guiding fund flows into the green environmental protection industry. This research thus uses panel data of 30 provinces and cities in China from 2000 to 2017 to examine the impact of a green credit policy on the level of energy efficient utilization. We establish the EBM (epsilon-based measure) super-efficiency model to measure the level of energy efficient utilization in China, apply the regression discontinuity design (RDD) model to empirically study the net effect of the green credit policy on the level of energy efficient utilization, and assess the policy’s regional heterogeneity. Finds present that the level of energy efficient utilization in China exhibits a fluctuating upward trend, and there are certain spatial heterogeneities across its regions. The overall level of the eastern region’s energy efficient utilization is the best, followed by the central and western regions in that order. The results of RDD based on the national perspective indicate that the green credit policy has a significantly positive effect on the level of energy efficient utilization, while subregional regression results reveal that improvement caused by implementation of the green credit policy varies across regions in China. The performance of improving energy efficiency in the eastern region is excellent, but the improvement effect in the central and western regions is so far not desirable.

To investigate the proportion and clinical characteristics of obstructive sleep apnea (OSA) in Chinese patients with polycystic ovarian syndrome (PCOS) through home sleep apnea test (HSAT) and to evaluate the reproductive endocrine and metabolic characteristics in these patients. The study was a cross-sectional analysis of infertile PCOS patients who underwent sleep respiratory monitoring between January and December 2019 at Peking University Third Hospital Reproductive Medical Center and respiratory and critical care medicine department. The prevalence of OSA, body mass index (BMI), menstruation, reproductive endocrine, and metabolic characteristics were collected in patients with PCOS. Logistic regression was performed to identify significant relationships among these factors and OSA. Amont 328 patients with PCOS, the prevalence of OSA was 40% (131/328), and six cases (5%) were severe. Univariate analysis showed that BMI and blood pressure were significantly higher in patients with OSA than in those without OSA (P

The rapid development of renewable energy industry in China has brought great demand for peak-regulation resources. As the flexibility of traditional thermal power plants are gradually exhausted, end-users with controllable devices, can be regarded as a kind of the promising flexible resources. The major problem that hinders distributed end-users from efficiently responding to the power system is the lack of the demand-side peak-regulation market mechanism. To this end, a peak-regulation market framework for demand-side in the presence of load aggregator (LA) is proposed in this paper, where LAs are responsible to integrate the flexible capacity of small-scale end-users to participate in the ancillary market. Firstly, LAs estimate the responsive capacity and the responsive cost of their signed end-users. Then, LAs will bid by their marginal utility prices at the proposed market platform operated by the system operator. Once the bidding is done, the system operator will clear the market and announce the bidding results. Meanwhile, each LA can guide the signed end-users by dynamic incentive price to change their load patterns. In addition, this paper further provides the market implementation steps, covering bidding, clearing and settlement. The simulation results show the proposed market model can offer an efficient market framework to integrate the flexible resources of distributed end-users for peak regulation to maximum consume the renewable energy.

The inherent intermittency and fluctuation of new energy bring great challenges to real-time dispatching and the controls in a power system with high penetration of renewable energy. It is difficult for traditional real-time dispatching of the power grid to deal with the conflicts among the consumption of new energy, the efficiency of the power grid and the carrying capacity of dispatchers. By constructing an intelligent trading system, which can realize the automatic adjustment and control of the provincial geographic tie line plan, a multi-source trans-provincial coordinated optimization control technology was proposed to achieve the optimization goal of the maximum utilization rate of new energy in the regional power grid, the maximum utilization rate of new energy transmission sections and the minimum transaction costs among provinces. Results of the operation in Northwest power grid show that this technology can effectively improve the utilization rates of new energy in various provinces and relevant new energy transmission sections, and effectively reduce the pressure on the carrying capacity of dispatchers caused by frequent transaction requirements between provinces as well. In this paper, the operation data of a typical day in Northwest power grid was selected to show the principle and effect of the multi-source trans-provincial coordinated optimization control technology proposed.

The increasing installed capacity of renewable energy such as wind power has put tremendous pressure on peak regulation of system. In order to promote wind power accommodation, a joint optimized peak regulation method for combined heat and power (CHP) units with heating storages and deep peak regulation is proposed in this paper, considering demand response. The power-generation side installs heat storage devices on CHP units, breaking the tradition of power determined by heat Also, the deep peak regulation technology of thermal power units is applied to increase the space for wind power accommodation. The load side considers demand response, and users are guided to actively optimize the load curve through peak regulation compensation incentives and time-of-use electricity prices, alleviating the phenomenon of anti-peak regulation of wind power. The joint optimization model aims to minimize the total dispatch cost of the system. Constraints on heating storages, costs of life loss of thermal power units and constraints on user satisfaction with electricity are all considered comprehensively. The model is solved by CPLEX. The results of the case study show that the proposed method can maximize the peak regulation effect of the system with the lowest dispatching cost while ensuring the user’s power consumption satisfaction, and effectively reduce the wind power curtailment.

Traditional photovoltaic power plant doesn't participate in grid frequency regulation, as the increasing proportion of photovoltaic power in the whole power system, it may have a great impact on the frequency stability. The new standard DL/T 1870-2018 "Technical Specification for Power System Network Source Coordination" issued in 2018 puts forward the requirements for fast frequency response performance of photovoltaic power plant. At some regions with high proportion of photovoltaic power in Northwest China, relevant departments have released documents successively, which claim the photovoltaic power plant should have the ability of fast frequency response. In this paper, according to the requirements of standard and local documents, the key technical indexes of fast frequency response of photovoltaic power plant are analyzed. Several typical schemes of fast frequency response renovation of photovoltaic power plant are listed. A high precision fast frequency response device is developed, the principle and control strategy of the device are introduced, this device is used in laboratory and photovoltaic power plant respectively. As shown in the field test, the fast frequency response performance of photovoltaic power plant is much better with this device, both the frequency regulation response time and power control accuracy are much better than conventional hydro-thermal power plant, this device has a high application value.

This study aimed to analyze the characteristics of cognitive impairment in adult-onset neuronal intranuclear inclusion disease (NIID). Seven patients with adult-onset NIID were collected consecutively from the memory clinic of Xuanwu hospital from February to December 2019. These cases were diagnosed with skin biopsy triggered by DWI high-intensity signals in corticomedullary junction on brain MRI. We used a battery of neuropsychological scales to detect the patient’s performance in each cognitive domain, and made a detailed analysis on the characteristics of cognitive impairment. All seven cases had cognitive impairment, and four of them had met the criteria for dementia. The scores of Montreal Cognitive Assessment and Frontal Assessment Battery were abnormal in all patients. The executive dysfunction was confirmed by the abnormal scores of Trail Making Test (5/7, 71%) and Clock Drawing Test (4/7, 57%). Bad performance in Auditory Verbal Learning Test (6/7, 86%) demonstrated that the memory was also a very commonly impaired cognitive domain. The low score on the animal fluency (4/7, 57%), Boston Naming Test (3/7, 43%), and Pentagon and Cube Copying Test (4/7, 57%) indicated that the language and visuospatial skills were also impaired. Fazekas scores were significantly correlated to the global cognition, executive and language functions (r = 0.788–0.906, P < 0.05). There is obvious impairment in multiple cognitive domains in adult-onset NIID, and both the executive dysfunction and memory deficit are very common. Leukoencephalopathy may be the main course of cognitive impairment in adult-onset NIID.

Background To compare the clinical efficacy of proximal femoral intramedullary fixation and anatomical locking compression plate in the treatment of femoral intertrochanteric fractures among the elderly. Methods In this retrospective study, 210 surgically treated patients with intertrochanteric fractures of the femur were analyzed and divided into groups A, B and C according to the surgical approach. Group A had interlocking compression nailing (INTERTAN) done (n = 69); group B had γ-III interlocking intramedullary nailing (γ-III) done (n = 73); and group C had proximal femoral anatomic locking plate (PFLP) done (n = 68). All patients’ data were followed up completely, and their clinical outcomes were observed. Results Group A and B were found to perform better than group C in operation time, bleeding volume, time of leaving bed, fracture healing time and hospitalization time (P 0.05). The Harris scores of groups A and B at 1, 3 and 6 months after operation were significantly higher than those of group C (P 0.05). Conclusions In the treatment of femoral intertrochanteric fractures, intramedullary fixation influences little on blood circulation at the fracture end, accelerates fracture healing, and enhances hip joint function, which assists patients in recovering faster postoperatively. Moreover, it enables them to gain mobility at an early stage and reduces postoperative complications of fractures. Its short-term clinical effects are better than extramedullary fixation, which should be more widely adapted clinically.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now become a pandemic threat to the whole world. At the same time, influenza virus has been active, with influenza virus and SARS-CoV-2 sharing the same transmission routes. This article aims to alert clinicians of the presence of co-infection with these two viruses and to describe the effect of the measures taken to fight COVID-19 on influenza prevention and control.

Strengthening organization and implementation to build a healthy China, is a major strategic task to cover modernization construction of our country. Strengthening organization and implementation is the key to ensuring the effective implementation of the goals and tasks of the Healthy China construction, and the key to transforming the blueprint into the effective improvement of people health. For the goal of on building moderately prosperous society by 2020, it has great significance to realize the Two Centenary Goals and the Chinese dream of the great rejuvenation of China. The Outline proposed that organization and leadership should be strengthened, and the evaluation system of health impact assessment should be established, to create a good social atmosphere and carry out the conduct monitoring work.

Firstly, the rapid development of urbanization has led to an increasing population of agricultural transfer. In 1978–2015, the urbanization rate in China increased by around 1.03 percentage points annually on average. In 2015, the total number of rural migrant workers reached 277.47 million, an increase of 35.24 million over 2010 (Fig. 3.1).

Health is the foundation of the all-round development of human beings and of the great significance to safeguarding national security, social stability and unity, and the economic development. Human resources are the first resource of China’s economic and social development. Health human resource is the health guardian of the people and an important support for building a moderately prosperous society in all respects, a healthy China and realizing the basic medical and health services for all. Health human resource status determines the level, ability and effectiveness of health service, and is the first resource for the undertaking of hygiene and health. Building a health human resource team of sufficient number, high quality, structure of optimization, and reasonable distribution is the foundation of our country’s continuous development of hygiene and health undertaking, and an important task to protect the health of the people. Strengthening the construction of health human resources is the overall requirement to implement the strategy of reinvigorating China through human resource development. In particular, with the deepening of the reform of medical and health system, the decisive position and role of the health talents are fully recognized, and the need to strengthen the construction of the health personnel team is becoming more and more urgent. The first is that with the development of economy and the changes of residents’ lifestyle, as well as the development of aging and urbanization, the demand for health services such as chronic diseases, public health, rehabilitation, elderly care and maternal and child health care is increasing. The second is that with the establishment of the hierarchical system of medical diagnosis and treatment, and the rapid development of information technology, the medical and health service mode and service level are deeply affected. The third is that with the globalization of health and the implementation of “One Belt and One Road” development strategy, higher requirements are put forward for international cooperation in the field of hygiene and health. All these changes have put forward the new requirements for health human resources. The talent problem is inevitable in further development of hygiene and health industry, for health talent is the health service provider and the powerful promoter of healthy China strategy. Therefore, it is necessary to further improve policies, strengthen human resources construction, arouse enthusiasm, and continuously meet the growing needs for health services of the people.

During the 12th 5-Year Plan Period, the State Council issued National Fitness Program (2011–2015) and the local governments above county level also issued Implementation Program for National Fitness. With the implementation of these programs, the national fitness campaign was widely carried out and people’s physical fitness and health kept on improving, which were mainly revealed in the following aspects

With rapidly increased number of medical institutions and ward beds as well as expanded scale of medical institutions, great achievements have been made in the medical and health service systems during the 12th 5-Year Plan period. While strengthening the construction of the medical insurance system, government has also continuously enhanced the construction of the public medical care delivery systems by various means, both providing support to medical care delivery systems and satisfying people’s needs, which created a favorable funding environment for the development of the health system. The increased medical professionals were 960,000 during the period between 2007 and 2010, with an average annual growth of 240,000, and 1673,600 during the period between 2010 and 2015, with an average annual growth of 334,700. Public funding also soared to a greater height during the same period. Government payment as a share of total health increased by 129 billion yuan from 2004 to 2007, 315 billion yuan from 2007 to 2010 and 674.28 billion yuan from 2010 to 2015. The increased percentage was from 22.3% in 2007, to 28.7% in 2010 and 30.4% in 2015.

The first is the challenge brought about by continuous decline in economic growth. Correspondently social security revenue and financial support to social security will also shift from rapid rise to stable and limited growth. With increasing rise in the need for social security and rapid increase in medical cost, pressure on social security funds is increasingly tremendous which will challenge social security continuously. The second is the challenge intensified by increased aging population. Aging population and low birth rate will impose impact on both revenue and expenditure of the old-age insurance and the medical insurance, leading to lack of medical insurance funds and weakened security capacity on the one hand, rapid rise in the need for medical care and dramatic increase in the expenditure of medical insurance funds on the other hand, which will pose increasingly serious risks for the sustainable development of the medical security system. The third is the challenge caused by increasingly accelerated pace of urbanization. Urbanization will not only give rise to rapid increase in demands for social security, which imposes pressure on social security funds, but also demands unity of urban and rural social security. Urbanization, together with its growing mobility of the population, poses a new challenge for the management service of social security. The fourth is the challenge posed by the multiple methods of medical service delivery and the application of network information technology. Multiple medical service delivery methods and tremendous impact of Internet+ will greatly change the service delivery modes and organizational structure, which will have fundamental influence on the operation of medical institutions and medical service practice and present huge challenges for medical security management.

Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive tract. During the past decades, the use of nanotechnology to modify traditional drugs targeting CRC has attracted researchers’ attention. Extensive research has been conducted in this field to achieve the goal of increasing the accumulation of drugs at tumor sites, improving drug efficacy, avoiding unnecessary drug exposure, reducing toxic and side effects, gaining ideal pharmacokinetic properties, as well as improving the quality of patients’ life. In this chapter, the development of nanomedicines, the EPR effect, the molecular mechanisms of CRC, and the application of nanotechnology in the treatment and diagnosis of CRC are reviewed. Furthermore, clinical applications of nanomedicines in cancer therapy are also summarized for a better understanding in targeting colorectal cancer via nanodrug delivery systems.

Major diseases refer to the illnesses that severely endanger public health and life safety of the people, severely affect the national economy and the development of society, and severely impair national security and our international image. Based on the characteristics of the present stage, five categories of 18 major diseases are selected as the representatives of major diseases, i.e. infectious diseases (AIDS, TB, hepatitis B, schistosomiasis, malaria, plague, cholera, echinococcosis, brucellosis), chronic diseases (hypertension, cerebral apoplexy, diabetes, lung cancer, liver cancer), mental diseases (severe psychonosema), occupational disease (pneumoconiosis) and endemic diseases (iodine deficiency disorders, Kaschin-Beck disease).

Health and longevity are not only the core objective of human development, but also the common wishes of people of all ethnic groups in our country. Healthy China is the China where the people can enjoy health and longevity and also the China where the people’s health and health service capacity have reached the world advanced level. From the following three dimensions—healthy life, quality of health and health capacity, Healthy China will provide the behavioral guidance and policy basis for individuals, families, health-related institutions, government departments and other entities to jointly construct a healthy China where people can enjoy health and longevity and where the economy and the society can carry each other.

With the construction of health information service system in the past 10 years or so and the rapid development of information technology and the Internet, the development trend of cross-border integration has been highlighted. Many new industry types have emerged such as smart manufacturing, online consumption and mobile healthcare. These new industry types are profoundly influencing and changing the organization of large-scale social production and people’s lifestyles. In the next 15 years, the cross-border integration of information technology and the Internet will continue, but what will be the trend? What changes in people’s health needs will take place when this trend is superimposed on the steady increase in urban and rural income levels, moderate population growth, aggravating population aging problems and other factors? What impact will these changes have on the health service supply and the development of the whole health industry? To sort out these issues will be of great significance to advancing the construction of “healthy China” and to the coordinated development of China’s economy and society and the attainment of the goal of “200 Years.”

Making improving the drug supply security system as an important task, the Outline of the Healthy China 2030 Plan requires to deepen the reform of the drug and device circulation system and to improve the national drug policies. The construction of drug supply security system is one of the key tasks of the new round of healthcare reform and, together with the medical service system, the medical security system and the public health service system, it serves the goal of providing basic medical and health services for everyone. The national essential drug system was initially established during the “11th 5-Year” period, which has laid the foundation for the formation of a drug supply security system. During the “12th 5-Year” period, positive progress has been made in consolidating and improving the essential drug system and promoting reform in the field of drug production and circulation.

From now to 2030, China’s economic level, service consumption, population development, scientific and technological progress will undergo profound changes, which will present the following main features

In response to climate change, the Chinese government has set a clear goal to reach its carbon peak by 2030 and achieve carbon neutrality by 2060, endeavoring to gradually realize net-zero carbon dioxide (CO2) emissions. This paper explores the concept of carbon neutrality and makes a comparative analysis of the gap between China, the European Union, and the United States vis-a-vis carbon neutrality based on international data. The main challenges China faces in its progress toward carbon neutrality are the following: first, China's energy consumption and CO2 emissions continue to increase, while its carbon peak has not yet been reached; second, carbon emission reduction in China is an arduous process, as the transition period allowed for the country to transition from its carbon peak to carbon neutrality is shorter than that of developed countries; third, China remains reliant on high-carbon fossil energy, with high energy consumption and low energy utilization efficiency; fourth, China's low level of economic development, compared with those of the EU, the US, or other developed countries, makes it relatively weak to withstand economic risks; and fifth, China's low-carbon and zero-carbon technologies are not mature. Therefore, this paper posits a three-stage/four-step strategy as well as seven specific suggestions that could benefit China's progress toward carbon neutrality.