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We utilized dynamic functional network connectivity (dFNC) analysis to compare participants with obsessive–compulsive disorder (OCD) with their unaffected first‐degree relative (UFDR) and healthy controls (HC). Resting state fMRI was performed on 46 OCD, 24 UFDR, and 49 HCs, along with clinical assessments. dFNC analyses revealed two distinct connectivity states: a less frequent, integrated state characterized by the predominance of between‐network connections (State I), and a more frequent, segregated state with strong within‐network connections (State II). OCD patients spent more time in State II and less time in State I than HC, as measured by fractional windows and mean dwell time. Time in each state for the UFDR were intermediate between OCD patients and HC. Within the OCD group, fractional windows of time spent in State I was positively correlated with OCD symptoms (as measured by the obsessive compulsive inventory‐revised [OCI‐R], r = .343, p, We identified several dFNC differences in OCD and UFDR that may be useful for establishing biomarkers of an OCD endophenotype. First, OCD patients had abnormal temporal properties which correlated with clinical features, which were shared with their UFDR. Second, we found similar connectivity patterns for UFDR and OCD within a dFNC state characterized by between‐network integration. These results provide new insights into the pathophysiology of OCD patients and indicate dynamic functional connectivity measures that could be used as biomarker to identify those at risk.

Highlights • Hub regions of the OCD brain network are proposed. • OCD patients and their unaffected first-degree relatives show a similar alteration of rich club organization. • Abnormal rich club organization is a vulnerability biomarker of OCD., Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, the structural and functional basis of this organization is still not very clear. Given the heritability of OCD, as suggested by previous family-based studies, we hypothesize that aberrant rich club organization may be a trait marker for OCD. In the present study, 32 patients with OCD, 30 unaffected first-degree relatives (FDR) and 32 healthy controls (HC) underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). We examined the structural rich club organization and its interrelationship with functional coupling. Our results showed that rich club and peripheral connection strength in patients with OCD was lower than in HC, while it was intermediate in FDR. Finally, the coupling between structural and functional connections of the rich club, was decreased in FDR but not in OCD relative to HC, which suggests a buffering mechanism of brain functions in FDR. Overall, our findings suggest that alteration of the rich club organization may reflect a vulnerability biomarker for OCD, possibly buffered by structural and functional coupling of the rich club.