1. The alternative pathaway of human T cell activation by monoclonal antibodies
- Author
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Chen Feng, Shi Wei, Xia Hanzhang, Xu Bingze, Li Yan-fen, Huang Yirong, Zhang Youhui, Chen Yuxian, and Zhang Xiaoying
- Subjects
Cancer Research ,Bladder cancer ,business.industry ,medicine.drug_class ,T cell ,Cancer ,medicine.disease ,Monoclonal antibody ,Epitope ,Lymphoma ,medicine.anatomical_structure ,Oncology ,Immunology ,medicine ,Alternative complement pathway ,business ,Kidney cancer - Abstract
This paper described T cell proliferative response by an alternative pathway in normal subjects and in patients with malignant diseases. Two McAbs, Anti-CCT1 and Lo-CD2-act recognizing two distinct epitopes on E-receptor (CD2) were used to costimulate PBMC. Proliferative responsiveness was measured by3H-thymidine incorporation. It was found that 82% of 72 normal subjects gave proliferative response whereas only 23% of the 93 patients did. The average cpm±SD in patients with bladder cancer (118±2314), kidney cancer (1619±2719) or lymphoma (2518±4057) was significantly lower than that in normal subjects (4935±2314), (P
- Published
- 1990
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