1. Inhibition of liver metastases in nude mice by the combined action of 5-fluorouracil and interferon
- Author
-
Arthur Katoh, William Petraiuolo, and Patrick McBee
- Subjects
Cancer Research ,Mice, Nude ,Spleen ,Interferon alpha-2 ,Drug Administration Schedule ,Metastasis ,law.invention ,Mice ,Liver Neoplasms, Experimental ,law ,Interferon ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Animals ,Pharmacology (medical) ,Pharmacology ,Dose-Response Relationship, Drug ,business.industry ,Splenic Neoplasms ,Interferon-alpha ,medicine.disease ,Recombinant Proteins ,Dose–response relationship ,medicine.anatomical_structure ,Oncology ,Cell culture ,Fluorouracil ,Recombinant DNA ,Cancer research ,Adenocarcinoma ,business ,Colorectal Neoplasms ,medicine.drug - Abstract
Liver metastasis in nude mice was studied using LoVo, a cell line developed from a patient with adenocarcinoma of the colon. LoVo cells injected into the spleen of 4-week-old nude mice showed 100% tumorigenicity in the spleen and metastases to the liver. This system was used to study ways in which to improve the efficacy of 5-FU, which was used in combination with alpha-2a interferon. Our results show that interferon can potentiate the effect of 5-FU in inhibiting liver metastases. Either drug given alone did not show comparable inhibition.
- Published
- 1990