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Aim During ablation of the posterior wall (PW), luminal oesophageal temperature elevation (OTE) prompts attenuation of radiofrequency (RF) energy delivery to minimize oesophageal injury. This strategy on lesion efficacy is unknown. The goal of this study was to analyse the relationship between OTE and pulmonary vein reconnection (PVR). Methods and results During the index antral pulmonary vein (PV) isolation procedure with an irrigated RF ablation catheter, OTE was detected with a multisensor oesophageal temperature probe. Posterior wall ablation did not exceed 25 W and was terminated when the temperature was ≥38.5°C. Patients undergoing redo procedures (n = 142) were studied for PW sites of PVR along 4 segments: left and right superior, and left and right inferior. Pulmonary vein reconnections had occurred in 51 of the 142 patients (36%), in 58 of 284 PV pairs (20%). Among these 58 reconnected pairs, 83% (n = 48) were along the PW. Oesophageal temperature elevation had occurred in 30 patients (59%). No difference in characteristics was seen between the patients with OTE (n = 30) and those without (n = 21). For superior segments, there was no interaction between the presence or absence of OTE and PVR. For inferior segments, there were more PVRs in the group with OTE: for the right-inferior segment, the PVR rate was 72% for OTE cases vs. 42% without (P = 0.04), and for the left-inferior segment, the PVR rate was 44% for OTE cases vs. 22.9% without (P = 0.12). Conclusion Pulmonary vein reconnections are predominantly posteriorly located. Along the right- and left-inferior PW segments, there was an association with elevated oesophageal temperature during the index procedure.

We report on the fabrication of a robust and flexible transparent electrode to replace costly and fragile indium tin oxide (ITO) used in flexible Cu(In,Ga)Se2 solar cells, composed of an aluminum doped zinc oxide (AZO)/Ag-nanowires/aluminum doped zinc oxide (AZO) (AAA herein) sandwich structure. The Ag-NWs networks form low-resistance, long-range pathways throughout the electrode that are able to maintain efficient charge carrier collection and extraction after strenuous mechanical bending. The improved durability of the AAA electrode enables our CIGS solar cells to maintain ∼95% of their initial power conversion efficiency, following 1000 bending cycles. In comparison, devices fabricated using AZO and ITO electrodes are only able to maintain ∼57 and ∼5%, respectively, due to crack formation and delamination of the films. This AAA sandwich structure electrode could therefore serve as a high-performance electrode for numerous flexible optoelectronic applications.

A facile wet soaking process by immersing a CIGS thin film in a mixed aqueous solution, containing gallium trichloride and thioacetamide at 80 °C for a few tens of seconds, was proposed to reduce the existence of defects in the CIGS absorption layer which can be confirmed by the temperature dependence of the open-circuit voltage (Voc). The depth profiles of X-ray photoelectron spectroscopy (XPS) results indicate that the gallium (Ga) concentration increases during the short wet soaking time, resulting in a widening of the band gap near the surface region. The enhanced carrier lifetime attributed to the Ga-induced defect reduction during thermal treatment of device fabrication was evaluated by time-resolved photoluminescence (TRPL) spectroscopy. With wet and light soaking processes, Voc, short circuit current (Jsc) and fill factor (F.F.) can be increased, yielding a significant enhancement in cell efficiency from ∼1% to ∼6.4%. We believe that this fast, simple and effective method can further stimulate the development of CBD-Zn(O,S)/post-selenization CIGS solar cells toward commercialized thin film photovoltaics.

Gait rehabilitation is an important process of medical treatments on lower extremity injuries for human neuromusculoskeletal system. Benefiting from the medical device automation technology in recent years, robots achieve the rehabilitation in a professional, precise and continuous manner by integrating mechatronics, automation, computer science and communication technologies, improving the qualities provided by human therapists, the labor-intensive works. This research proposes a Stewart Platform-based measurement system for human gait rehabilitation and test purposes. Related works are collected and analyzed, fetching a brief understanding of the market. Human gait model is constructed in 3D Studio Max and the CAD model is established in Solidworks. This research forms the mathematic models of kinetics and dynamics and performs the footplate posture simulations by using these models.

STUDY DESIGN The biomechanical effects of disc degeneration and hybrid fixation on the transition and adjacent segments were evaluated using a numerical approach. OBJECTIVE This study aimed to evaluate the rigidity-rising effects of the dehydrated disc and bridged fixator on the kinematic and mechanical redistribution of the transition and adjacent segments. SUMMARY OF BACKGROUND DATA After static fixation, a dynamic fixator can be used to preserve motion and share loads for the transition segments. However, the hybrid use of both static and dynamic fixators and its effects on the biomechanical behavior of the transition and adjacent segments were not investigated extensively. METHODS A nonlinear and osseoligamentous lumbar model from L1 vertebra to S1 vertebrae was developed. Ligament interconnection, muscular contraction, and weight compression were all used to simulate lumbar flexion. The static fixator was instrumented at the degenerative L4-L5 segment and the dynamic fixators (Dynesys system) with different stiffness were subsequently applied to the degenerative or healthy L3-L4 segment. A healthy lumbar model was used as a reference point for further comparison and evaluation. The predicted results were validated with the cadaveric and numerical values of the literature studies. Among the 21 models, the junctional problem at the adjacent (L2/L3 and L5/S1) discs as well as the motion preservation and stress distribution at the transition (L3/L4) disc were compared. RESULTS Static fixation and the degenerative disc deteriorated the junctional problem at adjacent segments. On average, the hybrid fixation of the original Dynesys cord constrained the range of motion (ROM) by 65%. Furthermore, it shared 43% of the stress on the transition disc. However, this resulted in the adjacent discs increasing about 50% ROM and 40% stress. The term "trade-off stiffness" was used to express the concept that the decreased stiffness of the original cord could balance the junctional problem, motion preservation, and load protection of the transition and adjacent segments. The trade-off stiffness of the degenerative transition disc was higher than that of the healthy disc. Compared with the original design, the increased ROM and stress of the adjacent segments can be reduced by about 43% using the trade-off stiffness. CONCLUSION The use of the hybrid fixator should involve a certain trade-off between the protection of the transition segment and the deterioration of the adjacent segments. This trade-off stiffness, which largely depends on both fixator design and disc degeneration, provides the improved rigidity and flexibility of the transition and adjacent segments.

Profile monitoring has received increasingly attention in a wide range of applications in statistical process control (SPC). In this work, we propose a framework for monitoring nonparametric profiles in multi-dimensional data spaces. The framework has the following important features: (i) a flexible and computationally efficient smoothing technique, called Support Vector Regression, is employed to describe the relationship between the response variable and the explanatory variables; (ii) the usual structural assumptions on the residuals are not required; and (iii) the dependence structure for the within-profile observations is appropriately accommodated. Finally, real AIDS data collected from hospitals in Taiwan are used to illustrate and evaluate our proposed framework.

Introduction: The primary goal of total knee arthroplasty (TKA) is to resolve knee destruction and associated problems at the end stages of diseases such as osteoarthritis and rheumatoid arthritis. High satisfactory rate has been reported in terms of pain relief and correction of deformity. However, the method for objective assessment of the outcome, such as range of motion (ROM) and quantitative evaluation of the clinical outcome of TKA, is to be confirmed. The purpose of this study was mandatory to investigate the ROM objectively and the newly designed prostheses. Materials and methods: The study was done in randomly selected patients who received dynamic measurement of knee function. Twenty-six patients participated in the study. They were divided into two groups (13 patients in A and 13 patients in B group), according to the knee prostheses they had received. Basic knee functions were evaluated in various dynamic activities, including nonweight bearing status of knee flexion, level walking, kneeling, and squatting, using computerized gait analysis techniques (Vicon 512 system). Passive knee ROM and static alignment were measured using traditional goniometer. HSS scores, physical, and neural examination were recorded. Results: After comparing patients in almost similar criteria, results have shown that there was no significant difference between two types of knee prostheses in randomly selective patients. Conclusion: Newly designed prostheses for achieving higher flexion angle cannot guarantee to provide better knee flexion for every patient. A patient, who can achieve higher knee flexion in pre-operative status, will have high flexion results in post-operative result. In other words, poor knee flexion function in pre-operation will lead to poor knee flexion function in post-operation status. Minor prosthesis design has little to do with the surgical outcome of knee flexion.

The use of costly and rare metals such as indium and gallium in Cu(In,Ga)Se2 (CIGS) based solar cells has motivated research into the use of Cu2ZnSnS4 (CZTS) as a suitable replacement due to its non-toxicity, abundance of compositional elements and excellent optical properties (1.5 eV direct band gap and absorption coefficient of ~104 cm−1). In this study, we demonstrate a one-step pulsed hybrid electrodeposition method (PHED), which combines electrophoretic and electroplating deposition to deposit uniform CZTS thin-films. Through careful analysis and optimization, we are able to demonstrate CZTS solar cells with the VOC, JSC, FF and η of 350 mV, 3.90 mA/cm2, 0.43 and 0.59%, respectively.

Defect control in Cu(In,Ga)Se2 (CIGS) materials, no matter what the defect type or density, is a significant issue, correlating directly to PV performance. These defects act as recombination centers and can be briefly categorized into interface recombination and Shockley–Read–Hall (SRH) recombination, both of which can lead to reduced PV performance. Here, we introduce an electrochemical passivation treatment for CIGS films that can lower the oxygen concentration at the CIGS surface as observed by X-ray photoelectron spectrometer analysis. Temperature-dependent J–V characteristics of CIGS solar cells reveal that interface recombination is suppressed and an improved rollover condition can be achieved following our electrochemical treatment. As a result, the surface defects are passivated, and the power conversion efficiency performance of the solar cell devices can be enhanced from 4.73 to 7.75%.

Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E(2) (PGE(2)) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE(2, )and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HAHI-HAHA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

We demonstrate, for the first time, an integration-friendly selective PMOSFET fully silicided (FUSI) gate process. In this process, a millisecond-anneal (MSA) technique is utilized for the nickel silicide phase transformation. A highly tensile FUSI gate electrode is created and hence exerts compressive stress in the underlying channel. The highly flexible integration scheme successfully, and exclusively, implements uniform P+ FUSI gates for PMOSFETs while preserving a FUSI-free N+ poly-Si gate for NMOSFETs with the feature size down to 30 nm. A 20% improvement in FUSI- gated PMOSFET Ion- Ioff is measured, which can be attributed to the enhanced hole mobility and the elimination of P+ poly-gate depletion.

Background Little is known about the biomechanical effectiveness of transforaminal lumbar interbody fusion (TLIF) cages in different positioning and various posterior implants used after decompressive surgery. The use of the various implants will induce the kinematic and mechanical changes in range of motion (ROM) and stresses at the surgical and adjacent segments. Unilateral pedicle screw with or without supplementary facet screw fixation in the minimally invasive TLIF procedure has not been ascertained to provide adequate stability without the need to expose on the contralateral side. This study used finite element (FE) models to investigate biomechanical differences in ROM and stress on the neighboring structures after TLIF cages insertion in conjunction with posterior fixation. Methods A validated finite-element (FE) model of L1-S1 was established to implant three types of cages (TLIF with a single moon-shaped cage in the anterior or middle portion of vertebral bodies, and TLIF with a left diagonally placed ogival-shaped cage) from the left L4-5 level after unilateral decompressive surgery. Further, the effects of unilateral versus bilateral pedicle screw fixation (UPSF vs. BPSF) in each TLIF cage model was compared to analyze parameters, including stresses and ROM on the neighboring annulus, cage-vertebral interface and pedicle screws. Results All the TLIF cages positioned with BPSF showed similar ROM ( Conclusions TLIF surgery is not favored for asymmetrical positioning of a diagonal cage and UPSF used in contralateral axial rotation or lateral bending. Supplementation of a contralateral facet screw is recommended for the TLIF construct.

In practice, sometimes the process data did not come from a known population distribution. So the commonly used Shewhart variables control charts are not suitable since their performance could not be properly evaluated. In this paper, we propose a new EWMA Control Chart based on a simple statistic to monitor the small mean shifts in the process with non-normal or unknown distributions. The sampling properties of the new monitoring statistic are explored and the average run lengths of the proposed chart are examined. Furthermore, an Arcsine EWMA Chart is proposed since the average run lengths of the Arcsine EWMA Chart are more reasonable than those of the new EWMA Chart. The Arcsine EWMA Chart is recommended if we are concerned with the proper values of the average run length. Na prática a distribuição de probabilidade de muitas variáveis não é conhecida e sabe-se que não é proveniente de uma distribuição normal. Segue que o uso dos gráficos de controle Shewhart não é conveniente e daí há necessidade de procurar outros gráficos de controle alternativos. Neste artigo um novo gráfico de controle do tipo EWMA é proposto. Ele utiliza uma estatística não paramétrica para monitorar a média de um processo e observou-se que é ágil para detectar pequenos desvios da média. Propriedades amostrais da estatística são exploradas e um exemplo ilustra a nova proposta. Além disto, outro gráfico do tipo EWMA é apresentado utilizando como estatística o arco-seno da estatística não paramétrica. Os valores de ARL’s deste gráfico apresentaram melhor desempenho do que a proposta anterior. Desta forma o gráfico Arco-Seno EWMA é recomendado se o critério do ARL for empregado.

Many existing pairwise key establishment in sensor networks were developed based on the polynomial-based method. However, this method cannot offer the basic authentication function of security. In this paper, we develop a novel tame-based approach to achieve the goal of authentication. We then present a general framework, for pairwise key establishment, in the basis of this tame-based approach. It turns out that this tame map can substitute the polynomial in any existing polynomial pool-based scheme to offer the authentication service. In particular, we further introduce a new scheme, local symmetric-tame maps predistribution scheme, based on this framework. The analysis demonstrates that, in addition to being able to provide authentication service, this scheme not only has significantly better performance, but also can achieve greater resilience on security than existing schemes.

Background This study was designed to derive the theoretical formulae to predict the pullout strength of pedicle screws with an inconstant outer and/or inner diameter distribution (conical screws). For the transpedicular fixation, one of the failure modes is the screw loosening from the vertebral bone. Hence, various kinds of pedicle screws have been evaluated to measure the pullout strength using synthetic and cadaveric bone as specimens. In the literature, the Chapman's formula has been widely proposed to predict the pullout strength of screws with constant outer and inner diameters (cylindrical screws). Methods This study formulated the pullout strength of the conical and cylindrical screws as the functions of material, screw, and surgery factors. The predicted pullout strength of each screw was compared to the experimentally measured data. Synthetic bones were used to standardize the material properties of the specimen and provide observation of the loosening mechanism of the bone/screw construct. Results The predicted data from the new formulae were better correlated with the mean pullout strength of both the cylindrical and conical screws within an average error of 5.0% and R 2 = 0.93. On the other hand, the average error and R 2 value of the literature formula were as high as -32.3% and -0.26, respectively. Conclusion The pullout strength of the pedicle screws was the functions of bone strength, screw design, and pilot hole. The close correlation between the measured and predicted pullout strength validated the value of the new formulae, so as avoid repeating experimental tests.

Fifteen elderly subjects with bilateral medial knee osteoarthritis (OA) and 15 healthy elderly subjects walked and crossed obstacles with heights of 10%, 20%, and 30% of their leg lengths while sagittal angles and angular velocities of each joint were measured and their phase angles (ϕ) calculated. Continuous relative phase (CRP) were also obtained, i.e., ϕhip−knee and ϕknee−ankle. The standard deviations of the CRP curve points were averaged to obtain deviation phase (DP) values for the stance and swing phases. Significant differences between the OA and control groups were found in several of the peak and crossing angles, and angular velocities at the knee and ankle. Both groups had similar CRP patterns, and the DP values of the hip–knee and knee–ankle CRP curves were not significantly different between the two groups. Despite significant changes in the joint kinematics, knee OA did not significantly change the way the motions of the lower limb joints are coordinated during obstacle-crossing. It appears that the OA groups adopted a particular biomechanical strategy among all possible strategies that can accommodate the OA-induced changes of the knee mechanics using unaltered inter-joint coordination control. This enabled the OA subjects to accommodate reliably the mechanical demands related to bilateral knee OA in the sagittal plane during obstacle-crossing. Maintaining normal and reliable inter-joint coordination may be considered a goal of therapeutic intervention, and the patterns and variability of inter-joint coordination can be used for the evaluation of treatment effects.

Background Despite improvements in shape, material, and coating for hip stem, both stress shielding and aseptic loosening have been the major drawbacks of stemmed hip arthroplasty. Some nonstemmed systems were developed to avoid rasping off the intramedullary canal and evacuating the bone marrow due to stem insertion. Methods In this study, the finite-element models of one intact, one stemmed, and two nonstemmed femora with minimal removal of the healthy neck were investigated to evaluate their biomechanical effects. The resurfacing (ball-shaped) and fitting (neck-shaped) systems were respectively selected as the representative of the ready- and custom-made nonstemmed implants. The stress distribution and interface micromotion were selected as the comparison indices. Results The results showed that stress distributions of the two nonstemmed femora are consistently more similar to the intact femur than the stemmed one. Around the proximal femur, the stem definitely induces the stress-shielding phenomenon of its counterparts. The fitting system with the anatomy-shaped cup can make intimate contact with the neck cortex and reduce the bone-cup micromotion and the implant stress. Comparatively, the reamed femoral head provides weaker support to the resurfacing cup causing higher interfacial micromotion. Conclusions The reserved femoral neck could act as the load-transferring medium from the acetabular cup, femoral neck, to the diaphysial bone, thus depressing the stress-shielding effect below the neck region. If the hip-cup construct can be definitely stabilized, the nonstemmed design could be an alternative of hip arthroplasty for the younger or the specific patients with the disease limited only to the femoral head. Electronic supplementary material The online version of this article (doi:10.1186/1471-2474-15-312) contains supplementary material, which is available to authorized users.