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Infantile haemangioma (IH) is a benign vascular tumour type that occurs in 3-10% of infants. In the present meta-analysis, previous studies comparing clinical outcomes, including the recovery rate and haemangioma activity score (HAS), adverse effects and relapse rates, were compared between patients treated with atenolol and those treated with propranolol for IH. A systematic search in various databases, including Medline, Cochrane Controlled Register of Trials, ScienceDirect and Google Scholar from inception until July 2019 was performed. The Cochrane risk of bias tool was used to assess the quality of published trials. A meta-analysis with a random-effects model and reported pooled mean differences (MD) or odds ratios (OR) with 95% CIs was performed. In total, 8 studies including 608 participants were analyzed. Only 2 studies were randomized controlled trials, while the majority of studies had low or unclear bias risks. Except for the response to medication (pooled OR=1.49; 95% CI, 0.85-2.18), all other outcomes (HAS, adverse reactions and relapse rate) were better for the atenolol group than the propranolol group. Atenolol resulted in better HAS (pooled MD=0.16; 95% CI, -0.42 to 0.73). Propranolol had more adverse reactions (pooled OR=2.17; 95% CI, 0.93-5.06) and a higher relapse rate (pooled OR, 1.67; 95% CI, 0.44-6.41) when compared to atenolol. However, these findings were not statistically significant. The results of this analysis suggest that atenolol may be non-inferior to propranolol and may offer advantages, including lower adverse reactions and relapse rates.

In this paper, a test structure of ring oscillator (RO) with addressable devices under test (DUTs) is described for the extracting of MOSFET capacitance-voltage (C-V) curves. With a high oscillation frequency, the influence of the gate-leakage current will be reduced to negligible. The addressable array and its calibration method in this work mitigate the impact from the layout, spatial and process variations, and improve the test accuracy. Moreover, the consumption of the layout area and test lines are also reduced by this structure.

In this letter, a change-flexibly-SELBOX-based FDSOI MOSFET, named hybrid device, is proposed, and the dependence of the open window's size and location on the thermal and electrical characteristics is investigated with technology computer-aided design (TCAD) simulation. An extensive comparative analysis of the key characteristics in hybrid device, FDSOI MOSFET without back bias (BB), and FDSOI MOSFET with BB have been performed. When the open window locates under the junction between channel and drain extension, the hybrid device is found to be most thermally efficient, compared to FDSOI MOSFET with/without BB and hybrid device with other window condition. Besides, the electrical characteristics in hybrid device strongly depend on the size and location of the open window, when the doping type of back plane (BP) is similar to source/drain region. The critical parameters, such as current density, electric potential, potential contours, electron mobility and density, are characterized and compared to investigate the underlying physical mechanisms. It reveals that the elevated electrostatic potential near SOI/BOX interface through the open window contributes to the observed electrical performance in hybrid device.

Propranolol is the mainstay of treatment for infantile hemangiomas (IHs) benefited from its low complication in the present study. However, it has an uncertainty treating period with cumbersome methods which may be related to clinical features. This study sought to considered possible influences of short-term efficacy to medication. Retrospective analysis of 82 patients with IHs treated by propranolol was performed. The patients were grouped according to effect (excellent, good and fair/poor). ANOVA or t test was used to assess the relationships between effect and clinical features of IHs. Twenty-seven patients were males and 55 were females. The median age of treatment initiation was 3.5 (±2.11) months. Mean follow-up time for the group was 6.2 months (1.5–16 months). There were no significant associations between short-term efficacy and gender, time points of treatment, diameter of tumor and multifocality. However, tumor thickness was associated with short-term efficacy (P = .013). Moreover, an obvious difference of short-term efficacy has been found when tumor thickness

This paper seeks to investigate the concepts of risk management and its implications for program management discipline. It highlights the distinctions of programs over projects and discusses why programs are more risky. Further, based on relevant descriptions and findings from respective literatures, we report a number of perceived barriers en route for risk management implementation on ground; we also discuss the reasons and rationales behind such infirmities. Dominant factors causingunderprivileged risk management are classified into four prime categories: resource constraints, contextual restrictions, learning imperfections and human limitations. An empirical survey-based study conducted from Pakistan telecom professionals discovers that monetary constraints, schedule compels, unstable organizational environment, lack of executive’s commitment towards risk, and deficit of risk-aware culture are the topmost barriers that impede the implementation of risk management in large-scale telecom programs in the country. The concepts defined in the early parts of this study will enable the practitioners to understand the program risk management subject in enhanced ways, while the findings delineatedlater can equip the relevant stakeholders with better learning of affairs prevalent in Pakistan telecom industry; this may also aid policy makers in instigating corrective actions.

Although risk management is an essential requisite for success of all endeavors, it is highly important to balance the risky contexts in the programmes for realizing the organizational gains and strategies. As the programmes remark a distinct locus in the organizational hierarchy, they mandate adoption of precise risk management approaches. Telecommunication development programmes are risky and complex undertakings; consequently they obligate meticulous controls in order to be prosperous. This study seeks the implementation of a specialized programme risk management procedure for a large-scale development programme – the Next Generation Wireless Mobile Services programme – in Pakistan telecom market. The proposed procedure follows the standard risk management process in an organized way, utilizes certain decision tools, and attempts to balance the risks facing the programme. It demonstrates how some information gathering ideas together with the popular tools e.g. the Analytical Hierarchy Process, the As Low as Reasonably Practicable rationale and the Standard Deviation notions can be used for balancing the risky environs in the subject programme. The results present substantive improvement in the risk exposures of said telecom programme and authenticate the methodology offered. This approach can also be useful in managing risks in a variety of other (large-scale) programmes.

Intra-arterial chemotherapy (IAC) has become an essential technique for the management of advanced intraocular retinoblastoma (RB). In this study, the aim of this article is to describe the clinical results and the short-term complications of IAC performed in our hospital. We retrospectively analyzed patients with newly diagnosed unilateral advanced intraocular (group D or E) RB undergoing IAC from October 2016 to December 2017 in our hospital. We recorded the data including age, gender, cycles of IAC, pathway of arteries approached (ophthalmic artery or middle meningeal artery), ocular and systematic complications, globe salvage. Sixty-one patients underwent IAC performing 189 procedures with a median of 3.1 sessions per eye (range, 1–5 sessions). The overall globe salvage rate is 78.7% (Group D (84.2%), and Group E (69.6%) and followed-up. Short-term ocular complications include eyelid edema (15 cases), ptosis (5 cases), forehead congestion (3 cases), retina hemorrhage (5 cases), choroid atrophy (2 cases), phthisis bulbi (1 case), bradycardia and hypotension during the procedure (7cases), myelosuppressions (6 cases), and nausea and vomiting (5cases). IAC is safe and effective for the treatment of unilateral advanced intraocular RB with a very low complication rate.

During an earthquake, the nonlinearity of the bridge structure mainly occurs at the supports, bridge piers and restrainers. When entering nonlinear stage, members of the bridge structure affect the elasto-plastic seismic response of the whole structure to a certain extent; for multi-span continuous bridges, longitudinal restrainers can be installed on the movable piers to optimise the distribution of seismic force and enable the movable piers to bear a certain amount of seismic effect. In order to evaluate the effect of nonlinearity of restrainer and supports on the elasto-plastic seismic response of continuous girder bridge, analytical models of continuous girder bridge structure considering the nonlinearity of movable supports, restrainers and bridge piers were built and the nonlinear time history analysis was conducted to evaluate the effect of nonlinearity of restraining devices and supports on the elasto-plastic seismic response of continuous girder bridge. Relevant structural measures and recommendation were made to reduce the seismic response of the fixed piers of the continuous girder bridge.

An extra-dosed cable-stayed bridge is taking as the practical engineering background to make the finite element nonlinear analysis of a section of reinforced concrete of the main tower by large software Ansys in this paper. Concrete cracking and crushing were considered, obtained the ultimate load of test model can bear as well as the stress-strain relationship of its steel and concrete, and draw a diagram of concrete crack distribution, when the value of concrete of the model to withstand the horizontal splitting stress, the bottom and top of the concrete of the saddle appeared signs of crack at the same time. The maximum compressive stress uniform distribution in the bottom area of the saddle and did not meet the design value of compressive strength, tensile stress first reached the limits of state.

The energy saving in rural residential housing has become the focus of building energy conservation, enhancing the capacity of farmer's home insulation is the fundamental measures of energy-saving design. With the existing rural residential in Tianjin, through full analyses of the Plane layout, building envelope, and other aspects of heating energy consumption, the energy-saving design strategy is proposed, thereby improving the planelayout, reducing the shape factor of rural residential house, enhancing the capacity of the external thermal insulation through using the native natural materials and construction techniques reasonably. Great effort is to be made to make rural housings be sustainable development, comfortable, economic, energy efficient and environmental friendly.

Building on previous research, this work argues that a company's absorptive capacity to improve its innovation performance will depend on sound management of its available outside network knowledge. Consequently, this study develops a research simulation model that links the properties of knowledge obtained from outside network, firm's absorptive capacity and the features of a firm's knowledge network topology to predict innovation performance. We find that the interaction between properties of knowledge, absorptive capacity and network topology has significant, positive effects on firm innovation performance.

Based on the analysis of the characteristics in the E-Commerce system and safety risk, the author has focused on the Fuzzy-ETA (event tree analyse)-FTA(fault tree analyse) method applied in the process risk management of R&D projects. The author has analyzed the possibility of an integration of EAT-FAT, and solved the problems in the integration of The Gray Synthetic Evaluation Theory by applying safety assessment model and application of the E-Commerce system, thus solving managerial problems in the E-Commerce system and safety risk with reliable and effective management guidance.

According to the many uncertain factors in group engineering project for Olympic telecommunication guarantee, complex giant system of typical characteristics and the resource leveling in group engineering project, the author mainly studied and put forward the use of heuristic algorithms, EXCEL modeling and established data model on resource leveling of group project. Empirical studies have shown that this method can effectively solve practical problems on resource leveling of group engineering project for Olympic telecommunication guarantee.