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Clinical implications of blood pressure variability (BPV) on subclinical organ damage in children are unknown. The authors sought to explore the potential utility of two newly derived BPV indices: weighted standard deviation (wBPSD) and real average variability (ARV), as well as two standard ambulatory blood pressure indices: average 24-hour systolic blood pressure (SBP) and 24-hour SBP load, to identify children at high risk for left ventricular (LV) hypertrophy (LVH). The study group consisted of 67 consecutive children who were referred to our institution for evaluation of suspected hypertension. LV mass was estimated by M-mode echocardiography using Devereux's formula according to the Penn convention and indexed for height(2.7) . We found a statistically significant, positive correlation between 24-hour wBPSD and LV mass index (LVMI) (ρ=0.389; P=.002) and no correlation between 24-hour ARV and LVMI (P>.05). However, partial correlation analysis of 24-hour wBPSD adjusted for body mass index (BMI) and LVMI showed only a weak correlation (ρ=0.3; P=.022). By using multiple linear regression analysis in a model with LVMI as a dependent variable and 24-hour wBPSD, 24-hour ARV, and BMI as independent variables, only BMI showed statistically significant independent positive associations with LVMI (P=.028). Results of our study showed that currently used BPV indices (24-hour wBPSD and 24-hour ARV) are not clinically reliable parameters to identify children at risk for LVH. Apparent contribution of the 24-hour wBPSD parameter to LVMI is negligible and is secondary to its close correlation with BMI (ρ=0.335 P=.009).

Introduction Myocardial hypertrophy of the left ventricle may be of physiological or pathological nature. Distinction of these two types of hypertrophy is sometimes not easy and represents a diagnostic challenge. The aim of the study was to assess global diastolic and regional systolic and diastolic myocardial function in the presence of left ventricular hypertrophy in athletes and hypertensive patients. Material and methods In 18 male hypertensive patients and 14 male athletes global diastolic left ventriclar function and regional systolic and diastolic myocardial function of septum and posterior wall were investigated by pulsed wave tissue Doppler imaging. Results Ejection fraction and left ventricle mass index did not differ significantly between two groups. Hypertensive patients were found to have diastolic dysfunction while athletes had normal left ventricular diastolic function (the difference between the groups was P

Purpose: To evaluate the effects of listening to favorite music on the endothelial function, assess through changes of circulating blood markers of endothelial function: the stable end product of Nitric Oxide (NOx), Dimethylarginine (ADMA), Symmetric Dimethylarginine (SDMA) and Xanthine Oxidase (XO), in patients (pts) with Coronary Artery Disease (CAD). Methods: 74pts with stable CAD were studied. At baseline and 3 weeks later, in all pts values of NOx, ADMA, SDMA and XO were evaluated and exercise test was performed. After the initial study, pts were randomized to trained (T,n=33), music and trained (MT, n=31) and music (M,n=10) group. Patients in T and MT group underwent a supervised 3 weeks aerobic exercise training at residential center. Additional to exercise training, patients in MT group were listening to their favorite music, for half an hour, every day. Patients in M group received usual community care and were listening to their favorite music for half an hour every day. Results: After 3 weeks NOx increased in T group (from 33.0±13.0 to 42.8±11.0 μmol/l, P< 0.005), MT group (from 34.5±7.1 to 49.6±12.6 μmol/l, P

Purpose: To evaluate the impact of low versus upper range intensity exercise training on endothelial function, through assessment of circulating blood markers of endothelial function: the stable end product of Nitric Oxide (NOx), dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and xanthine oxidase (XO), in patients (pts) with Heart Failure (HF). Methods: Twenty male pts admitted at residential rehabilitation center (mean age 54.1±11.1 years) with ejection fraction

OR-63 Key Words: Left Ventricular Hypertrophy, Kidney Disease, Diastolic Dysfunction