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Your search keyword '"Tristan Römer"' showing total 2 results
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2 results on '"Tristan Römer"'

1. Aggressive infantile myofibromatosis with intestinal involvement

Author

Robert Meyer, Miriam Elbracht, Norbert Wagner, Tristan Römer, Udo Kontny, Till Braunschweig, and Olga Moser

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Infantile myofibromatosis, Pharmaceutical Science, PDGFRB, Disease, Germline, Tyrosine-kinase inhibitor, 03 medical and health sciences, 0302 clinical medicine, PDGFRB mutation, Intestinal polyposis, medicine, Pharmacology (medical), Molecular targeted therapy, Chemotherapy, Case Study, business.industry, medicine.disease, Hematochezia, 030104 developmental biology, Complementary and alternative medicine, 030220 oncology & carcinogenesis, Intestinal Polyposis, medicine.symptom, business
Abstract

Molecular and Cellular Pediatrics 8, 7 (2021). doi:10.1186/s40348-021-00117-9, Published by Springer Open, Berlin

Published
2021
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2. Ectopic intracranial retinoblastoma in a 3.5‐month‐old infant without eye involvement and without evidence of heritability

Author

Dominik Sturm, Bernd Sellhaus, Tristan Römer, Andreas von Deimling, Michael Mull, Olga Moser, Petra Temming, Udo Kontny, and Dietmar R. Lohmann

Subjects
Male, Pathology, medicine.medical_specialty, Trilateral retinoblastoma, Retinal Neoplasms, Ubiquitin-Protein Ligases, Medizin, Brain tumor, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Autologous stem-cell transplantation, Germline mutation, medicine, Humans, Genetic Predisposition to Disease, Brain Neoplasms, Retinoblastoma, business.industry, Infant, Hematology, Prognosis, medicine.disease, Neuroblastic Tumor, eye diseases, Retinoblastoma Binding Proteins, Oncology, 030220 oncology & carcinogenesis, Mutation, Pediatrics, Perinatology and Child Health, DNA methylation, Histopathology, business, Stem Cell Transplantation, 030215 immunology
Abstract

Heritable retinoblastoma can rarely be associated with a midline intracranial neuroblastic tumor, referred to as trilateral retinoblastoma. We present an unusual midline brain tumor in an infant that was identified as ectopic retinoblastoma by histopathology, DNA methylation analysis, and molecular genetic detection of biallelic somatic inactivation of the RB1 gene. There was no ocular involvement, and germline mutation was excluded. In this nonresectable tumor, treatment with systemic chemotherapy including high-dose therapy with autologous stem cell transplantation, but without definite local therapy, resulted in long-lasting tumor control.

Published
2019
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