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Background: Elevated serum uric acid concentration and arterial stiffness are both risk factors for hypertension. Serum uric acid is also associated with arterial stiffness. Whether serum uric acid affects blood pressure through arterial stiffening is yet unsolved, with very limited observational studies. Methods: Participants were selected from Kailuan Study (2008-2016), who were free of cardiovascular diseases and anti-hypertensive drugs. Arterial stiffness was measured by brachial-ankle pulse wave velocity. Parameters of blood pressure included systolic and diastolic blood pressure, mean artery pressure, and pulse pressure. Study Group I consisted of participants with baseline uric acid, brachial-ankle pulse wave velocity at next follow-up visit (~2 years), and blood pressure at a third follow-up (~4 years); Study Group II consisted of participants with complete data in a single visit. Correlations were tested by multivariate linear regressions. Role of arterial stiffness in connecting uric acid to blood pressure was tested by mediation analyses. Findings: In Study Group I, correlations were found between serum uric acid and arterial stiffness (R2=0.299, P

In recent years, as one of the internet finance innovations, crowdfunding business model can concentrate the funds, ability and channels of everybody to provide the necessary fund assistance for a certain activity. The college students entrepreneurship crowdfunding website is the service platform to provide the entrepreneurial fund support for college students' entrepreneurs, which can help the college students overcome the difficulty in funds and management faced by the traditional entrepreneurship in the past. By investigating and surveying, this paper conducts a comprehensive research on the developments of college students entrepreneurship crowdfunding website from design, development and promotion, aiming at needs of developments of the hip crowdfunding in China with the practical situation, whose services can increase the quantity of visiting the website and provide high quality service for the existing consumers.

The crowdfunding is a financing mode, which can support project initiated by the other people or organizations through chatting on the internet, project sponsor provide a certain return to investors. In the crowdfunding pattern, the college students entrepreneurs can communicate with a large number of heterogeneous public at the same time, which increases the financing opportunities and benefits. Base on the college students entrepreneurship crowdfunding, this paper explores construction and application for college students entrepreneurship crowdfunding platform. This paper puts forward some constructive suggestions on design, compositions, profit earning and technology of college students entrepreneurship crowdfunding platform, aiming at meetting the requirements of the college students entrepreneurs.