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Objective To evaluate the efficacy and safety of a Chinese medicine (CM) Modified Qufeng Runmian Powder (, MQFRMP) for the treatment of acne vulgaris with CM syndromes of dampness and blood stasis. Methods In this multicenter, randomized, double-blind, placebo-controlled clinical trial, 220 acne vulgaris patients with CM syndrome of dampness and blood stasis were included and randomly assigned using a central area group random design to receive either MQFRMP or the placebo, with 110 cases in each group. MQFRMP or a placebo at 145 g/bag were administered once daily for 4 weeks, respectively. The primary index of efficacy was the effective rate according to the acne severity score (ASS). The secondary indices of efficacy included the changes in the dermatology life quality index (DLQI) score, VISIA scores (spots, pores, brown spots, porphyrins and red areas) and skin assessment (skin pH, sebum amount and hydration) according to a SOFT skin multianalyzer. Results (1) Follow-up: a total of 204 patients completed the follow-up, with 103 in the treatment group and 101 in the control group. (2) Effective rate: the total effective rate of the treatment group was significantly higher than the control group [83.5% (86/103) vs. 31.7% (32/101), P 0.05). (6) Safety: two cases of mild drug allergy were observed in the treatment group. Conclusion MQFRMP was effective and safe for the treatment of acne vulgaris with syndromes of dampness and blood stasis. (No. ChiCTR1900020479).

In order to improve quality of reconstructed frame for distributed video coding(DVC) over wireless mobile Ad hoc networks, a streaming transmission scheme with burst loss tolerance over wireless mobile Ad hoc network was proposed. Consider the fact that non-linear of pixel movement in distributed video coding sequences, the neural network was designed and trained offline using different standard distributed video sequences to achieve generalization. Therefore, the neutral network was exploited to predict the GOP size of distributed video coding sequences, and the rate control method which could be adaptive adjusts the feedback time for blocks in frame was proposed. The Experiment results show that the proposed scheme for DVC has a superior PSNR performance compared with conventional scheme, and enhanced the quality of video in wireless mobile Ad hoc network.

Background Cervical cancer is the second leading cause of death in women 20–39 years old. Because coverage for cervical cancer screening is low, and the vaccination rate of human papillomavirus (HPV) is poor in some countries, potential markers to detect the disease at early stages are needed. E2F transcription factors (E2Fs) are a family of transcription factors that function in cell proliferation, differentiation, apoptosis, and tumorigenesis. As abnormal activation and regulation of E2Fs are related to tumor development and poor prognosis, we performed bioinformatic analyses and in vitro assays to evaluate the role of E2Fs in cervical cancer. Methods Transcriptional expression of E2Fs was initially evaluated in silico using ONCOMINE and Gene Expression Profiling Interactive Analysis (GEPIA), followed by evaluation of E2F1/2/7/8 protein levels using immunohistochemistry in 88 patient tissues. E2F2 and E2F7 mRNA levels were measured by RT-qPCR. LinkedOmics and Metascape were used to predict functions of E2Fs, and in vitro experiments were performed to assess the tumorigenic role of E2F2 and E2F7. Results In silico analysis showed that E2F1/2/7/8 were significantly overexpressed in cervical cancer, findings which were confirmed at the protein level using immunohistochemistry. Further, upregulation of E2F1/2/7/8 was associated with different clinicopathological prognostic factors, including positivity for lymph vessel invasion and deep invasion of cervical stroma. Increased expression of E2F1/2/7/8 was also related to shorter overall survival (OS) and disease-free survival (DFS) in patients with cervical cancer. Using multivariate analysis, we confirmed E2F1/2/7/8 as independent prognostic factors for shorter OS of patients with cervical cancer. Finally, in vitro experiments showed that E2F2 and E2F7 are involved in cell proliferation and migration and cell cycle regulation in both HPV-positive and HPV-negative cervical cancer cells. Conclusions E2F1/2/7/8 may be prognostic biomarkers for survival of patients with cervical cancer. E2F2 and E2F7 are involved in cell proliferation, migration, and cell cycle in both HPV-positive and HPV-negative cervical cancer cells.

Focusing properties of high-numerical-aperture micro-Fresnel zone plates (FZP) have been rigorously investigated at the wavelength from deep ultraviolet to visible based on the combination of the vectorial angular spectrum theory and three-dimensional finite-difference time-domain method. New insights are found. The axial spot size evaluated by full-width-at-half-maximum is in direct proportion to the inverse of the total annulus number. Linearly negative focal shift phenomenon can be observed due to the wavelength dispersion over a finite range of tens of nanometers. A proper wavelength deviation can lead to the maximum focal intensity. A simple method has been demonstrated to probe either multi-focus or a light needle using a composite microstructure based on high-NA FZPs. The findings of this study expand the common understandings of the classic widely-used FZPs.

Digital terrestrial multimedia broadcasting (DTMB) passive radar obtains target information by eliminating correlation between reference signal and target echo signal. Reference signal reconstruction is a key technology of passive radar. This paper introduces the key algorithms in the process of reference signal reconstruction. On the premise of ensuring the reconstruction accuracy, DOMP-MP algorithm is used to reduce the computational complexity. The reconstructed reference signal and the target echo are processed by 2D Cross-correlation processing to obtain the target information. The simulation results demonstrate that the algorithm is verified.

A phase-compensator (PC) is needed in compensating for the phase distortions of a digital system such as digital-signal-processing (DSP) systems and telecommunication systems. This indicates that a PC must be designed to meet a given phase design specification. The intrinsic nonlinearity of the phase of an allpass system inevitably makes the PC design nonlinear. This paper discusses the nonlinear issue involved in the design of a digital allpass PC. To design an allpass PC using a linear-optimization method, it is desirable to develop an approximate linear error expression so that the error expression (cost function) is linear with respect to the allpass PC parameters (coefficients). This paper aims to derive and show two different linear error expressions that can be used to design an allpass using a linear-optimization technique. Consequently, the problem of designing an allpass PC can be approximately reduced to a linear-optimization problem. Using a linear-optimization method and the newly developed linear error expressions to design an allpass PC yields an approximate design with reasonable design accuracy, but the design procedure becomes much simpler than the case using a nonlinear error function. That is, the linear error expressions facilitate the PC design and can achieve a reasonably accurate PC with reduced design complexity through employing a linear-optimization approach.

Diabetic Retinopathy (DR) is the most common cause of avoidable vision loss, predominantly affecting the working-age population across the globe. Screening for DR, coupled with timely consultation and treatment, is a globally trusted policy to avoid vision loss. However, implementation of DR screening programs is challenging due to the scarcity of medical professionals able to screen a growing global diabetic population at risk for DR. Computer-aided disease diagnosis in retinal image analysis could provide a sustainable approach for such large-scale screening effort. The recent scientific advances in computing capacity and machine learning approaches provide an avenue for biomedical scientists to reach this goal. Aiming to advance the state-of-the-art in automatic DR diagnosis, a grand challenge on "Diabetic Retinopathy - Segmentation and Grading" was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI - 2018). In this paper, we report the set-up and results of this challenge that is primarily based on Indian Diabetic Retinopathy Image Dataset (IDRiD). There were three principal sub-challenges: lesion segmentation, disease severity grading, and localization of retinal landmarks and segmentation. These multiple tasks in this challenge allow to test the generalizability of algorithms, and this is what makes it different from existing ones. It received a positive response from the scientific community with 148 submissions from 495 registrations effectively entered in this challenge. This paper outlines the challenge, its organization, the dataset used, evaluation methods and results of top-performing participating solutions. The top-performing approaches utilized a blend of clinical information, data augmentation, and an ensemble of models. These findings have the potential to enable new developments in retinal image analysis and image-based DR screening in particular.

To identify the weak links of the emergency rescue system in coal enterprises, this study assessed the vulnerability of this system with the Group Gray Analytical Hierarchy Process (GGAHP), which combined the Group Decision Making and Grey Theory. By setting up the index system about vulnerability and judgment matrix, then whitening the matrix, the vulnerability data at the bottom of the index system could be calculated to spot the weak links of the system.

Fei-Xiang Wu,1–3,* Hui-Rong Lu,4,* Shao-Liang Zhu,1,* Zi-Hui Li,1 Ling Zou,1 Tao Bai,1 Jie Chen,1 Tian-Bo Yang,1 Shi-Xiong Liang4,51Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 2Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, Nanning, 3Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Shanghai, 4Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 5Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workObjective: The current study aimed to evaluate the efficacy and outcomes of three-dimensional conformal radiotherapy (3DCRT) combined with transarterial chemoembolization (TACE) for treating patients with hepatocellular carcinoma involving portal vein tumor thrombus.Methods: During 2000 and 2013, a total of 182 hepatocellular carcinoma patients with portal vein tumor thrombus were retrospectively analyzed: 68 patients were treated by 3DCRT alone (group A), 74 by TACE alone (group B), and 40 by a combination of 3DCRT + TACE (group C). The overall survival (OS) of the three groups was compared using the Kaplan–Meier method. The independent predictors of survival were identified using multivariate analysis.Results: The total effective rate (complete response + partial response) among all patients was 44% (80/182). The objective response rate (complete response + partial response) was higher in group C than in group A or B, but the differences were not significant. OS rates at 1, 2, and 3years were significantly higher in group C than in group A or B (P

China’s economic development has entered into a stage of “new normal”, with the market-oriented reform of electricity is deepening, the market risks faced by power generation enterprises are becoming increasingly severe. To reduce the loss caused by market risks and promote the efficiency of market operation, this paper established and evaluated the credit evaluation system for power generation enterprises. Specifically, based on spot power trading market, this paper firstly established a credit risk evaluation index system by assessing the credit risk of market trading members from four main aspects; then, the credit risk of typical enterprises has been analysed by fuzzy synthetic evaluation method. The result showed that power generation enterprises should focus on improving their financial ability such as profit and debt repayment in the operation process, attention should also be paid to integrity due to improving the performance rate of spot trading in the transaction process.

Super-oscillatory lens (SOL), a new type of planar optical element developed in recent years, may play an important role in the integrated optics, microscopy, advanced sensor, and astronomy. Based on the vectorial angular spectrum theory and genetic algorithm, both binary amplitude-type and phase-type SOLs are designed. Various sub-diffraction focusing properties can be realized by optimizing the design procedure. In order to investigate the focusing characteristics of SOLs under different illumination conditions, rigorous electromagnetic simulation calculations of the diffracted focusing light field are implemented by the finite-difference time-domain method. The results show that when the beam waist radius w0 of the illuminating laser is less than the SOL radius a, not only the capability of super-diffraction limit focusing will decrease significantly, but also the intensity of the focal spot will attenuate by more than 50%. Comparing with the amplitude-type SOL, the waist radius w0 has a strong effect on the phase-type SOL and causes a significant focus to shift in the positive direction. However, if w0 is larger than 2a, the ideal focusing characteristics of SOL can be maintained. Under the condition of oblique illumination, the high numerical aperture amplitude-type SOL generally only allows a small inclination angle of less than 10°, while the phase-type SOL has a wide inclination adaptability (can exceed 40°) regardless of the numerical aperture. For the latter, the focal spot will expand laterally and the intensity will decrease sharply with the increase of inclination angle. As for low numerical aperture phase-type SOL, the focusing characteristics, including focal spot size, focusing intensity and the angular position of the focus, can keep stable within an inclination angle of 18°. For imaging infinitely distant objects, the oblique illumination will produce a fluctuating field curvature and significant negative distortion for high numerical aperture SOLs, while for the low numerical aperture SOLs, the field curvature increases with inclination angle increasing and the distortion disappears almost. The research results of this paper provide an important theoretical basis for practical applications of super-oscillatory lens in the fields of sub-diffraction light focusing, super-resolution microscopic imaging, and micro-nano processing of femtosecond laser direct writing.

NF-κB interacting lncRNA (NKILA) has been found to function as a tumor-suppressive role in various human cancers. However, the role of NKILA in rectal cancer is still unknown. The objective of this study is to investigate the clinical value and biological function of NKILA in rectal cancer. The association between NKILA expression and clinical variables including prognosis was estimated in rectal cancer patients. The gain-of-function study of NKILA in rectal cancer cell was conducted to evaluate the effect of NKILA on cell proliferation, migration, invasion, and NF-κB signaling pathway. The results suggested NKILA expression was decreased in rectal cancer tissues and cells, and correlated with clinical stage, T classification, N classification and M classification. NKILA low-expression was an independent poor prognostic factor in rectal cancer patients. NKILA-inhibited rectal cancer cell proliferation, migration, and invasion via suppressing NF-κB signaling. In conclusion, NKILA serves as an antioncogenic lncRNA in rectal cancer.

We studied theoretically the THz radiation emission induced by an electron beam moving atop a graphene sheet based on a structure consisting of 2D square lattice of dielectric cylinders. Numerical evaluation result shows that the THz radiation frequency can be turned in a range of 10 THz by adjusting the Fermi level or the filling fraction of the dielectric cylinders, and the peak radiation intensity, which largely depends on the velocity of the electron beam, is the order of 10 −3 μJ/cm 2 . These results indicate a promising application in developing the THz radiation source.

Background: Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory. Materials and Methods: A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. Results: A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity. Conclusions: The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.

Questionnaire survey, as an important means, has been more and more widely used, however, compared to the fixed content, form a single traditional questionnaire survey, network questionnaire system not only brings considerable convenience to the people’s work, but also has a low cost, high efficiency, across space limitations, rich forms, interactive and other advantages. Through a detailed analysis of various methods of questionnaire survey, combined with the actual needs of the current project, developing a B/S model design and implementation of a questionnaire survey system which is based on J2EE. System to achieve a questionnaire to create, manage, publish, statistics, and questionnaire template library and exam management and other functions, to shorten the cycle of the survey, making the survey more timeliness.

How to ensure the reliability of the data translated in some insecure channel has been a big problem, which influences the communication quality deeply. To solve that, the concept of message authentication is proposed which has been widely used and proved efficient. In this thesis, we proposed a message authentication scheme based on chaotic quantum cryptosystem in this scheme. And the security and reliability is analyzed which shows that this scheme could guarantee the message security validly against different kinds of attack. We hope this will do some favor to the future of communication security.

Effective detection of software defects is an important activity of software development process. In this paper, we propose an approach to predict residual defects for BOSS project, which applies defect distribution model. Experiment results show that this approach can effectively improve the accuracy of defect prediction.

In order to improve network reliability and stability of the core layer, multiple devices are connected together through the IRF physical port, IRF (Intelligent Resilient Framework) configuration, virtual into “virtual equipment”. Using the virtualization technology can set the equipment resources of the hardware and software processing capability, collaborative work, the equipment management and the uninterrupted maintenance. Through introduce the basic concepts and working principles of H3C Switches IRF system, also analyzes the typical applications of IRF technology in network system.

The third-party certification industry in China has been gradually stepping on the right track. However, it has not yet gained a foothold in rural building material market. Since the “12th Five-Year Plan” came into being, the new countryside construction is extremely urgent. Therefore, it is very necessary to establish a third-party certification system to regulate and standardize rural building material market. By using the game theory method, this paper analyzed the operating model of third-party certification organization under the economy of monopoly market, and put forward the third-party certification system which was suitable for rural building material market, in the meanwhile, proposed several suggestions in the management models of certification organization for government supervision departments.

In the fiercely competitive product market, product designs have already moved from the product-oriented approach to a marketing-oriented approach, and gradually to a customer-oriented approach. Therefore, it is of high necessity to study users’ emotional needs aroused by the product's multi-dimensional design variables. This paper contributes a systematically emotional design method of products’ hard interface based on Kansei Engineering (KE), which can be used to design a product that echoes users’ emotions. Based on the representative pairwise Kansei image words and multi-dimensional key design variables obtained by the consumer-oriented techniques, the KE models are established. Finally, the integration of KE models and Genetic Algorithm is employed to search for a near-optimal design scheme. This proposed method is effectively demonstrated in terms of the mini digital camera. It can be used in various design cases to optimise the product emotional design.