15 results on '"Therese Eriksson"'
Search Results
2. Identifying potential areas for an expanding wolf population in Sweden
- Author
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Fredrik Dalerum and Therese Eriksson
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0106 biological sciences ,education.field_of_study ,biology ,Range (biology) ,business.industry ,010604 marine biology & hydrobiology ,Species distribution ,Population ,Distribution (economics) ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Optimal management ,Geography ,Canis ,Reindeer husbandry ,Carnivore ,business ,education ,Socioeconomics ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation - Abstract
Large carnivores have historically been decreasing worldwide, often as a result of human-carnivore conflicts. However, large carnivores are recovering throughout Europe, and European management scenarios can provide important insights into broad issues related to human-large carnivore existence. After becoming almost extinct in Sweden during the mid-19th century the Swedish grey wolf (Canis lupus) population has now recovered. Current national wolf management aims to promote distribution shifts from the current areas in central Sweden, potentially also into a previously exempt reindeer husbandry area. Prior wolf re-introductions have highlighted the necessity of pro-active management for colonization success. Identification of likely range expansion areas could therefore be paramount for a successful Swedish wolf management. We characterized the demographic and spatial progression of Swedish wolves during 2001–2015 and used a MaxEnt approach to species distribution models to identify potential range expansion areas. The Swedish wolf population had expanded from 10 to almost 60 reproductions or territorial pairs, and increased in both range size and density. Our distribution models suggested that Swedish wolf management may face trade-offs between costs of hosting wolves in densely populated areas in southern Sweden with cattle and sheep and the costs of allowing wolves to expand into reindeer husbandry areas with associated cultural and economic consequences. Spatially explicit data on the economic, social and cultural factors associated with wolf conflict and acceptance may be paramount for developing optimal management strategies in the face of such a trade-off.
- Published
- 2018
3. Organisational design and development in a large rail tunnel project — Influence of heuristics and mantras
- Author
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Anna Kadefors and Therese Eriksson
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Engineering ,Process management ,business.industry ,media_common.quotation_subject ,05 social sciences ,0211 other engineering and technologies ,02 engineering and technology ,Discretion ,Rule of thumb ,Management of Technology and Innovation ,021105 building & construction ,0502 economics and business ,Satisficing ,Operations management ,Business and International Management ,Project management ,Heuristics ,Adaptation (computer science) ,business ,Social heuristics ,050203 business & management ,media_common ,Meaning (linguistics) - Abstract
In design phases of large and complex infrastructure projects, a main challenge is to coordinate numerous technical specialists. Heuristics, or cognitive rules of thumb, is one factor that may influence the development of organisational structures and routines, especially if project management discretion is high: A longitudinal case study, comprising non-participant observation over three years, was carried out of the early design phase of a major railway tunnel project. Availability and familiarity heuristics were found important, as well as coordination neglect a general tendency to focus more on partitioning tasks than on coordination needs. Satisficing, meaning that the first acceptable organising solution is selected and retained, was found to be strong in temporary, transitory contexts. Shared heuristics were manifest as short catchphrases, or mantras. Clients should develop meta-routines and meta-functions to support adaptation within, and learning between, projects.
- Published
- 2017
4. Designing and implementing incentives for engineering consultants: encouraging cooperation and innovation in a large infrastructure project
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Therese Eriksson and Anna Kadefors
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Scheme (programming language) ,Value (ethics) ,Information Systems and Management ,Knowledge management ,Relation (database) ,Process (engineering) ,business.industry ,Strategy and Management ,Building and Construction ,Task (project management) ,Incentive ,Key (cryptography) ,Business ,Engineering (miscellaneous) ,computer ,computer.programming_language ,Railway tunnel - Abstract
In large infrastructure projects, important decisions are made in early design phases. For a client, a key issue is how to stimulate innovative joint performance within the design team. This paper investigates the process of designing and implementing bonuses for cooperation and innovation in a large urban railway tunnel project. Data were collected through non-participatory observations, documents, interviews and a survey. Previous research has shown that incentives influence performance positively or negatively depending on task contents and perceived intentions, but also that people tend to underestimate this complexity and over-emphasize the power of incentives. Based on case observations, effects of bonuses for engineering consultants are discussed in relation to client awareness and management resources. The case results suggest that there are low risks for negative effects on task motivation of design consultants if incentives are low-stakes and not tied to specified performance. However, for low-stake incentives to add value, symbolic roles and the communication processes generated by the incentive scheme need to be strategically and purposefully managed. We conclude that research is needed to guide clients in considering a wider range of measures for enabling innovation and collaboration in design teams.
- Published
- 2015
5. Developing Routines in Large Inter-organisational Projects: A Case Study of an Infrastructure Megaproject
- Author
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Therese Eriksson
- Subjects
Engineering ,Public infrastructure ,Process management ,business.industry ,Project commissioning ,Management science ,Context (language use) ,General Business, Management and Accounting ,lcsh:TH1-9745 ,lcsh:TA177.4-185 ,Design phase ,lcsh:Engineering economy ,Publishing ,Organisational performance ,Megaproject ,Duration (project management) ,business ,lcsh:Building construction - Abstract
General management research has increasingly recognised the significance of routines in organisational performance. Among organisational tasks, megaprojects depend more on routines selected and created within the project than standard, small-scale projects do, owing largely to their size, duration, and uniqueness. Within this context, the present paper investigates how project routines were established and developed during the early design phase of an inter-organisational megaproject. A case study of a large public infrastructure project was conducted, in which data were collected during observations, semi-structured interviews, and project document studies over the course of three years. Results of analysis revealed that the client exerted the greatest impact on choice of routines and that the temporary nature of tasks limited efforts to fine-tune routines. Changes in routines were primarily reactive to new knowledge concerning project needs. The findings suggest that meta-routines to consciously review routines should be used to a greater extent and designed to capture supplier experiences as well.
- Published
- 2015
6. A comparison of perceived occupational gaps between people with stress-related ill health or musculoskeletal pain and a reference group
- Author
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Hans Jonsson, Therese Eriksson, Kerstin Tham, and Gunilla Eriksson
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Gerontology ,Occupational therapy ,Adult ,Male ,medicine.medical_specialty ,Work ,Activities of daily living ,Time Factors ,medicine.medical_treatment ,Social group ,Young Adult ,Leisure Activities ,Musculoskeletal Pain ,Surveys and Questionnaires ,Stress (linguistics) ,Activities of Daily Living ,medicine ,Humans ,Reference group ,Sweden ,Rehabilitation ,Descriptive statistics ,business.industry ,Public Health, Environmental and Occupational Health ,Middle Aged ,Sick leave ,Physical therapy ,Female ,Perception ,Sick Leave ,business ,Stress, Psychological - Abstract
To describe and compare how occupational gaps were reported in everyday occupations in a rehabilitation group of people with musculoskeletal pain or stress-related ill health and in a reference group from the Swedish population.Seventy-two persons with musculoskeletal pain or stress-related ill health and 261 people from the Swedish population were included. The Occupational Gaps Questionnaire, measuring to what extent individuals perceive a discrepancy between what they want to do and what they actually do, was completed by the participants. Descriptive statistics were used to analyse the data.Occupational gaps were reported more often in the rehabilitation group. Leisure activities were the gaps reported most often. The occupational repertoire seemed to decrease over time as the number of activities was decreasing, particularly leisure and work-related activities. Instrumental ADL were more desirable as the length of sick leave extended.Being on sick leave appears to start a process towards occupational deprivation where the areas that remain in the occupational repertoire become more important. Our study highlights the need to emphasize the whole occupational repertoire in rehabilitation and to facilitate engagement in valued activities to create a sound base for the process of returning to work.
- Published
- 2011
7. A Correction to the Research Article Titled: 'Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens' by Brian Alexander, Jennifer Warner-Schmidt, Therese Eriksson, Carol Tamminga, Margarita Arango-Llievano, Subroto Ghose, Mary Vernov, Mihaela Stavarche, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G. Kaplitt
- Author
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Margarita Arango-Llievano, Therese Eriksson, Carol A. Tamminga, Mihaela Stavarche, Jennifer L. Warner-Schmidt, Marc Flajolet, Per Svenningsson, Michael G. Kaplitt, Subroto Ghose, Brian L. Alexander, Sergei Musatov, Paul Greengard, and Mary Vernov
- Subjects
business.industry ,Genetic enhancement ,Translational medicine ,Medicine ,General Medicine ,Nucleus accumbens ,business ,Neuroscience - Published
- 2010
8. Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens
- Author
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Brian, Alexander, Jennifer, Warner-Schmidt, Therese, Eriksson, Carol, Tamminga, Margarita, Arango-Lievano, Margarita, Arango-Llievano, Subroto, Ghose, Mary, Vernov, Mihaela, Stavarache, Mihaela, Stavarche, Sergei, Musatov, Marc, Flajolet, Per, Svenningsson, Paul, Greengard, and Michael G, Kaplitt
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Small interfering RNA ,Genetic enhancement ,Genetic Vectors ,Nucleus accumbens ,Article ,Nucleus Accumbens ,Viral vector ,Mice ,Internal medicine ,medicine ,Humans ,Animals ,Psychiatry ,Receptor ,Annexin A2 ,Depression (differential diagnoses) ,5-HT receptor ,Depression ,business.industry ,S100 Proteins ,Genetic Therapy ,General Medicine ,Dependovirus ,Endocrinology ,Serotonin ,business - Abstract
Despite much progress in the study and treatment of depression, the mechanisms underlying this debilitating disease are still unclear. Altered activity of several major neurotransmitters in the brain including serotonin is involved, but pinpointing the parts of the brain affected in depression has proved challenging. Alexander and colleagues now implicate a brain region called the nucleus accumbens and a protein called p11 expressed in this region as important mediators of depression in humans and mice. The authors were alerted to the potential importance of p11 in depression because mice that lack this protein show depressive-like behavior. This protein is involved in the activation of two receptors for serotonin, 5-HT1B and 5-HT4. Alexander et al . decided to down-regulate expression of p11 specifically in the nucleus accumbens by injecting a viral vector containing a small interfering RNA against p11 directly into this brain region in healthy mice. They then tested the treated mice to see if they exhibited depressive-like behaviors in response to two stress tests (suspension by the tail and swimming in a water tank). In both tests, treated mice showed greater immobility compared with control animals, a sign of depressive-like behavior. To show that these depressive symptoms were indeed caused by loss of p11 in the nucleus accumbens, the investigators overexpressed p11 in the nucleus accumbens of mice that completely lacked this protein. They demonstrated restoration of normal immobility times on the two stress tests and an increased desire to sip sucrose solution (a treat that rodents normally enjoy but depressed animals do not). They also showed increased activity of 5-HT1B serotonin receptors expressed by striatal neurons in the nucleus accumbens of mice overexpressing p11. But do these results have any relevance to depression in humans? Alexander and colleagues tackled this question by comparing postmortem nucleus accumbens brain tissue from individuals with and without depression at the time of death. They discovered that expression of p11 was much lower in the nucleus accumbens of depressed individuals compared with healthy persons. These new findings pinpoint the nucleus accumbens and the p11 protein as important mediators of depression and provide new therapeutic targets for drug development.
- Published
- 2010
9. Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial
- Author
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Ana Ruiz, Jerome Kabakyenga, Piero Olliaro, Therese Eriksson, Tharcise Ngambe, François Coussement, Walter R. J. Taylor, Jean-Paul Guthmann, Loretxu Pinoges, William Perea, Dominique Legros, and Gerardo Priotto
- Subjects
Male ,medicine.medical_specialty ,Sulfadoxine ,medicine.medical_treatment ,Drug Resistance ,Artesunate ,Pharmacology ,Parasitemia ,Gastroenterology ,chemistry.chemical_compound ,Antimalarials ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Artemisinin ,Malaria, Falciparum ,biology ,business.industry ,Public Health, Environmental and Occupational Health ,Infant ,Plasmodium falciparum ,General Medicine ,medicine.disease ,biology.organism_classification ,Sulfadoxine/pyrimethamine ,Artemisinins ,Drug Combinations ,Infectious Diseases ,Pyrimethamine ,Treatment Outcome ,Tolerability ,chemistry ,Child, Preschool ,Parasitology ,Drug Therapy, Combination ,Female ,business ,Sesquiterpenes ,Malaria ,medicine.drug ,Follow-Up Studies - Abstract
Drug-resistant malaria is spreading in Africa. The few available drugs might be safeguarded if combined with an artemisinin derivative. We investigated the efficacy, safety, and tolerability of 2 combinations of artesunate with sulfadoxine-pyrimethamine (SP) in a mesoendemic region in Uganda with SP resistance, from September 1999 to June 2000. In a randomized, double-blind, placebo-controlled trial, 420 children aged 6-59 months with uncomplicated Plasmodium falciparum malaria were assigned SP alone (25 mg/kg sulfadoxine, 1.25 mg/kg pyrimethamine) or combined with artesunate (AS; 4 mg/kg/d) for either 1 d (SPAS1) or 3 d (SPAS3). Children were followed-up for 28 d. Day 14 cure rates were 84.6% (99/117) with SPAS3 and 61.9% (73/118) with SPAS1 compared with 55.8% (86/154) with SP. Corresponding day 28 results were 74.4% (87/117) and 45.2% (52/115) compared with 40.5% (62/153). A significant improvement was obtained with the addition of 3 d, but not 1 d, of artesunate (risk ratio [RR] = 1.5, 95% CI 1.3-1.8 at 14 d and RR = 1.8, 95% CI 1.5-2.3 at 28 d). Both AS regimens achieved significantly faster parasite clearance and lower gametocyte carriage. All drug regimens were well tolerated, but SP alone was ineffective. Treatment efficacy improved with SPAS3 but the cure rate at day 28 was modest. The combinations were well tolerated and safe. In areas where SP resistance is prevalent other combinations should be considered.
- Published
- 2004
10. P.2.018 Behavioural and cognitive alterations of the young megencephaly (BALB/cByJ-Kv1.1 mceph/mceph) mouse
- Author
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Therese Eriksson, Sven-Ove Ögren, E. Åberg, Catharina Lavebratt, and Sarah Holst
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Pharmacology ,Psychiatry and Mental health ,Neurology ,business.industry ,Medicine ,Pharmacology (medical) ,Cognition ,Neurology (clinical) ,business ,Neuroscience ,Biological Psychiatry - Published
- 2011
11. P.2.d.015 Glutamatergic deficits and differential antidepressant regulation in rat model of depression
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Michael Spedding, Sven-Ove Ögren, Philippe Delagrange, Per Svenningsson, Therese Eriksson, Maurizio Popoli, and Aleksander A. Mathé
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Pharmacology ,business.industry ,Rat model ,Psychiatry and Mental health ,Glutamatergic ,Neurology ,Medicine ,Antidepressant ,Pharmacology (medical) ,Neurology (clinical) ,business ,Neuroscience ,Biological Psychiatry ,Differential (mathematics) ,Depression (differential diagnoses) - Published
- 2011
12. S.16.01 Potential therapeutic targets from cellular/molecular signalling mechanisms in depression models
- Author
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K. Björk, M. El Yacoubi, Therese Eriksson, Sven-Ove Ögren, Aleksander A. Mathé, Per Svenningsson, and J.-M. Vaugeois
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Pharmacology ,Psychiatry and Mental health ,Signalling ,Neurology ,business.industry ,Medicine ,Pharmacology (medical) ,Neurology (clinical) ,business ,Neuroscience ,Biological Psychiatry ,Depression (differential diagnoses) - Published
- 2010
13. Reduction of droplet volume by controlling actuating waveforms in inkjet printing for micro-pattern formation
- Author
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Therese Eriksson, Xuechuan Shan, Yee Cheong Lam, Hiong Yap Gan, and B K Lok
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Materials science ,Precision engineering ,Inkwell ,business.industry ,Mechanical Engineering ,Drop (liquid) ,Nozzle ,Nanotechnology ,Piezoelectricity ,Electronic, Optical and Magnetic Materials ,PEDOT:PSS ,Mechanics of Materials ,Newtonian fluid ,Optoelectronics ,Waveform ,Electrical and Electronic Engineering ,business - Abstract
Inkjet printing has proven to be a promising and flexible process methodology for low cost and drop-on-demand pattern formation in small-scale production of micro-electro-mechanical systems. To optimize the micro-patterns formed by inkjet printing, an accurate control of droplet volume is essential and critical. In this study, an inkjet system with a nozzle driven by a circular piezoelectric element was used to explore the impact of different waveforms on droplet volume. The investigation into this study included the impact of unipolar, bipolar, M-shaped and W-shaped waveforms as well as the effects of their amplitudes and pulse durations. The inkjetting behavior of Newtonian and non-Newtonian fluids under different actuating waveforms was studied in order to obtain a maximum reduction in ejected droplet sizes. An effective reduction of droplet volume in the range of 50-80% was demonstrated. The results of inkjetting PEDOT ink on a polished silicon surface showed that a 50% reduction in line width was achieved.
- Published
- 2009
14. P.1.c.048 5-HT7 receptors interact with NMDA and 5-HT1A receptor-dependent emotional learning and exploratory activity in mice
- Author
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E. Elvander-Tottie, Benita Sjögren, Therese Eriksson, J.C. Budd, Per Svenningsson, and S.O. ö gren
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Pharmacology ,business.industry ,Psychiatry and Mental health ,Neurology ,Social emotional learning ,NMDA receptor ,5-HT1A receptor ,Medicine ,Pharmacology (medical) ,Neurology (clinical) ,Receptor ,business ,Neuroscience ,Biological Psychiatry - Published
- 2007
15. Evaluation of serological assays for diagnosis of Onchocercosis
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Cecilia Thors, Catharina Lavebratt, Gabriel Guzman, Inger Ljungström, Hannah O. Akuffo, and Therese Eriksson
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Microbiology (medical) ,Immunoblotting ,Helminthiasis ,Dot blot ,Fluorescent Antibody Technique ,Enzyme-Linked Immunosorbent Assay ,Immunofluorescence ,Onchocerciasis ,Ghana ,Sensitivity and Specificity ,Brugia malayi ,Serology ,Antigen ,parasitic diseases ,Medicine ,Animals ,Humans ,Anthelmintics ,Acanthocheilonema viteae ,Chi-Square Distribution ,Ivermectin ,General Immunology and Microbiology ,biology ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,General Medicine ,biology.organism_classification ,medicine.disease ,Onchocerca volvulus ,Infectious Diseases ,Antigens, Helminth ,Immunoglobulin G ,Immunology ,Onchocerca ,business - Abstract
Microscopic analysis of skin snips is the most widely used diagnostic technique for onchocercosis in endemic countries. The invasive nature and low sensitivity of that procedure has called for alternative diagnostic methods for this disease. Presently, serological assays detecting filariosis in general are available for routine analysis. However, serological assays specific for onchocercosis are still not universally available. We have evaluated the performance of a dot blot assay (DBA) as a potential method for specific detection of onchocercosis. The DBA, which detects IgG, as compared with 2 IgG4-immunoblot assays, all employing Onchocerca volvulus antigen. Furthermore, an enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence assay (IFA) based on antigens from Acanthocheilonema viteae and Brugia malayi, respectively, were included in the comparison. Samples from microfilariae-positive patients and negative controls from the onchocercosis-endemic country Ghana were analysed. The DBA was significantly more sensitive and specific than the IgG4-assays and the ELISA, respectively. Furthermore, the anti-filarial Ig was increased in patients 1 month post-ivermectin treatment. Sera from patients with suspected filariosis from different parts of the world were analysed using DBA, ELISA and IFA. Patients responding positively in the DBA (12%) had clinical symptoms compatible with onchocercosis whereas those positive in ELISA and IFA (53% and 48%, respectively) had various clinical symptoms. These results indicate that the DBA is more specific than and as sensitive as the ELISA and the IFA presently used for the diagnosis of onchocercosis.
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