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1. PIED-A-TOWER: Grecian fluting, glinting metalwork, and eye-popping modern art: A 1901 seven-story townhouse on New York's Upper East Side rediscovers its true north at the hands of Jesse Carrier and Mara Miller

Author: Flanigan, Jeffrey, Loof, Thomas, Have, Mieke Ten, and Barbour, Celia
Subjects: Motion picture theaters, Business, General interest
Abstract: The words storybook house generally refer to an abode lifted from a fairy tale. But imagine instead an Edith Wharton novel set on a sci-fi spaceship following a collision with [...]
Published: 2024

2. EVOLVING THE NATIONAL WEATHER SERVICE TO BUILD A WEATHER-READY NATION: Connecting Observations, Forecasts, and Warnings to Decision-Makers through Impact-Based Decision Support Services: The vision of the NWS is to build a Weather-Ready Nation by connecting accurate and timely forecasts and warnings to decisions that save lives and protect property

Author: Uccelini, Louis W. and Hoeve, John E. Ten
Subjects: United States. National Weather Service, United States. National Centers for Environmental Prediction, United States. National Oceanic and Atmospheric Administration, United States. Department of Commerce, Extreme weather -- Social aspects, Business, Earth sciences, National Academy of Public Administration -- Social aspects, Weather Research and Forecasting (Scientific software)
Abstract: ABSTRACT As the cost and societal impacts of extreme weather, water, and climate events continue to rise across the United States, the National Weather Service (NWS) has adopted a strategic [...]
Published: 2019
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3. Norm conflict in the governance of transnational and distributed infrastructures: the case of Internet routing

Author: Niels ten Oever and ASCA (FGw)
Subjects: International relations, Public Administration, Sociology and Political Science, business.industry, Corporate governance, Geography, Planning and Development, IP forwarding, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Management, Monitoring, Policy and Law, Computer security, computer.software_genre, Global governance, Internet governance, Norm (artificial intelligence), Infrastructural power, The Internet, Business, General Economics, Econometrics and Finance, computer
Abstract: This paper explores how a deeply embedded norm can be used to exert power and control in the governance of distributed infrastructures, such as the Internet. Through the lens of norm conflict, I analyse a case of resistance against the introduction of norms in the transnational governance of Internet routing. In a mixed-methods case study, I examine through an experiment how a community of network operators resists the introduction of data protection and human rights norms in the Internet routing infrastructure. To provide a possible explanation as to how a prevalent and deeply embedded norm enables the resistance to the introduction of new norms, I develop the notion of ‘infrastructural norms’. This concept could help explain why Internet infrastructure governance thus far has largely defied national and international democratic norms. The understanding of how norms are used in infrastructure governance contributes to the study of power in large technical systems.
Published: 2023

4. The Role of the Weather, Water, and Climate Enterprise in the Proposed SEC Rule on Climate-Related Disclosures

Author: Hoeve, John E. Ten
Subjects: United States. Securities and Exchange Commission -- Powers and duties, Financial disclosure -- Laws, regulations and rules -- Environmental aspects, Securities law -- Environmental aspects, Climatic changes -- Environmental aspects -- Laws, regulations and rules, Government regulation, Business, Earth sciences
Abstract: The Securities and Exchange Commission (SEC) recently proposed a new rule requiring routine climate change disclosures from all publicly traded companies, beginning in fiscal year 2023 for the largest filers [...]
Published: 2022

5. LABOR OF LOVE: Education, economic development and jobs services build the future workforce

Author: Saylor, Ten
Subjects: Caron International Inc. -- Training, National Spinning Company Inc. -- Training, Labor force -- Economic aspects, Textile industry -- Economic aspects -- Training, Employee development -- Economic aspects, Education, Business, Business, regional
Abstract: When the Canada-based Spinrite Services LLC craft-yarn manufacturer announced plans to move its packaging operations from Washington, N.C., to a new facility in Georgia last September, about 30 employees faced [...]
Published: 2019

6. Variation of platelet function in clinical phenotypes of acute venous thromboembolism – Results from the GMP‐VTE project

Author: Kirsten Leineweber, Vincent ten Cate, Philipp S. Wild, Karl J. Lackner, Bianca Wagner, Stefan Heitmeier, Imke Meyer, Lisa Eggebrecht, Marina Panova-Noeva, Markus Nagler, Thomas Koeck, Jürgen H. Prochaska, Christoph Gerdes, Stavros Konstantinides, Hugo ten Cate, Henri M. H. Spronk, RS: Carim - B04 Clinical thrombosis and Haemostasis, Interne Geneeskunde, MUMC+: HVC Pieken Trombose (9), MUMC+: MA Alg Interne Geneeskunde (9), and MUMC+: HVC Trombosezorg (8)
Subjects: medicine.medical_specialty, pulmonary embolism, Platelet Function Tests, PULMONARY-EMBOLISM, platelet function, Deep vein, venous thromboembolism, 610 Medizin, DETERMINANTS, Gastroenterology, deep vein thrombosis, DISEASE, Pathogenesis, chemistry.chemical_compound, Platelet degranulation, RISK-FACTOR, 610 Medical sciences, Internal medicine, Humans, Medicine, Platelet, cardiovascular diseases, POPULATION, Venous Thrombosis, business.industry, Hematology, medicine.disease, ABSENCE, Thrombosis, PREDICTS, Pulmonary embolism, ASPIRIN, Adenosine diphosphate, Phenotype, Epinephrine, medicine.anatomical_structure, chemistry, thrombin generation, VOLUME, business, medicine.drug
Abstract: Background The role of platelets in the pathogenesis of venous thromboembolism (VTE) is receiving increasing attention; however, limited information is available on platelet function in the acute phase of the disease. Objective To characterize platelet function according to VTE phenotypes. Patients/Methods In total, 154 subjects (isolated pulmonary embolism [iPE], n = 28; isolated deep vein thrombosis [iDVT], n = 35; DVT+PE, n = 91) were included. In this study platelet function analyzer (PFA)-200, light transmission aggregometry (LTA), thrombin generation (TG) in presence (PRP) and absence (PFP) of platelets and platelet flow cytometry were investigated. LASSO regression was used to select clinical and platelet biomarkers that distinguish between VTE phenotypes. Results PFA-200 results did not differ between VTE phenotypes. LTA from DVT+PE subjects showed lowest maximum aggregation after epinephrine and adenosine diphosphate compared to iPE and iDVT. Lower % of PAC-1-positive platelets after in-vitro trigger were present in DVT+PE and iPE compared to iDVT. TG in PRP had lower peak height and velocity in DVT+PE and iPE against iDVT. The results of LASSO regression for the distinction between DVT+PE vs iDVT identified 18 variables (AUC =0.93) of which 72% were platelet biomarkers. For distinction between iPE and iDVT, 10 variables were selected (AUC = 0.96) of which 50% were platelet-related. Obesity was the only variable weakly discriminating between DVT+PE vs iPE (AUC = 0.66). Conclusion This explorative study suggests an important distinction between PE-related phenotypes and iDVT when considering clinical and platelet function data. Lower platelet-dependent TG along with reduced platelet reactivity suggest higher platelet degranulation in PE-dependent phenotypes compared to iDVT.
Published: 2022

7. The role of checkpoint inhibitors in paraneoplastic acute exudative polymorphous vitelliform maculopathy

Author: J C Ten Berge, J Jacob, P P Schauwvlieghe, D Kemels, and Ophthalmology
Subjects: medicine.medical_specialty, business.industry, Melanoma, Immune checkpoint inhibitors, Mucosal melanoma, Retinal detachment, General Medicine, Exudates and Transudates, medicine.disease, Dermatology, Discontinuation, Vitelliform Macular Dystrophy, Ophthalmology, Nivolumab, medicine, Maculopathy, Humans, Stage (cooking), Fluorescein Angiography, business
Abstract: Purpose:To report on two cases with paraneoplastic acute exudative polymorphous vitelliform maculopathy within one month after the initiation of nivolumab. Methods:Case report. Results:Two patients with metastatic mucosal melanoma were diagnosed with acute exudative polymorphous vitelliform maculopathy within one month after the initiation of the checkpoint inhibitor nivolumab. Both cases showed a neurosensory retinal detachment and subretinal hyperautofluorescent material, which persisted after discontinuation of nivolumab and treatment with local and/or systemic corticosteroids. In one case, nivolumab was introduced again in a later stage in combination with surgical reduction of the tumor, eventually leading to resolution of the subretinal lipofuscin-rich fluid.Conclusion:The development of paraneoplastic acute exudative polymorphous vitelliform maculopathy in melanoma patients can be triggered by treatment with nivolumab. However, achieving tumor control, which may involve continuation of nivolumab, could be the key to success.
Published: 2022

8. Guided and unguided de-escalation from potent P2Y(12) inhibitors among patients with acute coronary syndrome

Author: Samin K. Sharma, Carlo Andrea Pivato, Anne H. Tavenier, George Dangas, Kiyuk Chang, Frans Beerkens, Dominick J. Angiolillo, Marco Valgimigli, Mauro Chiarito, Samantha Sartori, Johny Nicolas, Davide Capodanno, Roxana Mehran, Usman Baber, Renicus S Hermanides, Jur ten Berg, Davide Cao, Annapoorna Kini, Arnoud W J van 't Hof, Matteo Nardin, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H01 Clinical atrial fibrillation, and RS: Carim - B04 Clinical thrombosis and Haemostasis
Subjects: medicine.medical_specialty, Acute coronary syndrome, Ticagrelor, Prasugrel, medicine.medical_treatment, DOSE PRASUGREL, Hemorrhage, Percutaneous Coronary Intervention, Internal medicine, Humans, Medicine, Pharmacology (medical), P2Y(12) inhibitor, Stroke, ELDERLY-PATIENTS, POLYMORPHISMS, Aspirin, business.industry, Percutaneous coronary intervention, DUAL ANTIPLATELET THERAPY, medicine.disease, Clopidogrel, OPEN-LABEL, GENE, De-escalation, ASPIRIN, Conventional PCI, Cardiology and Cardiovascular Medicine, business, INTERVENTION, Platelet Aggregation Inhibitors, medicine.drug
Abstract: Aim Optimal dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) intends to balance ischemic and bleeding risks. Various DAPT de-escalation strategies, defined as switching from a full-dose potent to a reduced dose or less potent P2Y12 inhibitor, have been evaluated in several ACS-PCI trials. We aimed to compare DAPT de-escalation to standard DAPT with full-dose potent P2Y12 inhibitors in ACS patients who underwent PCI. Methods and results PubMed, Google Scholar, and Cochrane Central Register of Controlled Trials were searched for eligible randomized controlled trials. Aspirin monotherapy trials were excluded. Five randomized trials (n = 10 779 patients) that assigned DAPT de-escalation (genetically guided to clopidogrel n = 1242; platelet function guided to clopidogrel n = 1304; unguided to clopidogrel n = 1672; unguided to lower dose n = 1170) vs. standard DAPT (control group n = 5391) were included in this analysis. DAPT de-escalation was associated with a significant reduction in Bleeding Academic Research Consortium ≥2 bleeding (HR 0.57, 95% CI 0.42–0.78; I2 = 77%) as well as major adverse cardiac events, represented in most trials by the composite of cardiovascular mortality, myocardial infarction, stent thrombosis, and stroke (HR 0.77, 95% CI 0.62–0.96; I2 = 0%). Notwithstanding the limited power, consistency was noted across various de-escalation strategies. Conclusion De-escalation of DAPT after PCI for ACS, both unguided and guided by genetic or platelet function testing (PFT), was associated with lower rates of clinically relevant bleeding and ischemic events as compared to standard DAPT with potent P2Y12 inhibitors based on five open-label RCTs reviewed.
Published: 2022

9. Improving community health worker treatment for malaria, diarrhoea, and pneumonia in Uganda through inSCALE community and mHealth innovations: A cluster randomised controlled trial

Author: Agnes Nanyonjo, Maureen Nakirunda, Gus ten Asbroek, Patrick Lumumba, Godfrey Ayebale, Betty R. Kirkwood, Frida Kasteng, Seyi Soremekun, Anna Vassall, Edmound Kertho, Karin Källander, Raghu Lingam, Daniel Strachan, James K Tibenderana, Sylvia Meek, Benson Bagorogoza, Zelee Hill, Global Health, and APH - Global Health
Subjects: medicine.medical_specialty, business.industry, Informed consent, Relative risk, Family medicine, Community health, Absolute risk reduction, Psychological intervention, Medicine, Cluster randomised controlled trial, business, Institutional review board, mHealth
Abstract: Background: The inSCALE cluster randomised controlled trial evaluated two interventions, mHealth and Village Health Clubs (VHCs) which aimed to improve Community Health Worker (CHW) treatment for malaria, diarrhoea, and pneumonia within the Integrated Community Case Management programme. Methods: In a cluster randomised trial, 39 sub-counties in Midwest Uganda, covering 3167 CHWs, were randomly allocated to mHealth; VHC or usual care (control) arms. Household surveys captured parent-reported child illness, care seeking and treatment practices. Intention-to-treat analysis estimated the proportion of appropriately treated children with malaria, diarrhoea and pneumonia according to WHO informed national guidelines. Registration: ClinicalTrials.gov (NCT01972321). ResultsBetween April-June 2014, 7679 households were surveyed; 2806 children were found with malaria, diarrhoea or pneumonia symptoms in the last one month. Appropriate treatment was 11% higher in the mHealth compared to the control arm (risk ratio [RR] 1·11, 95% CI 1·02, 1·21; p=0·018). The largest effect was on appropriate treatment for diarrhoea (RR 1·39; 95% CI 0·90, 2·15; p=0·134). The VHC intervention increased appropriate treatment by 9% (RR 1·09; 95% CI 1·01, 1·18; p=0·059), again with largest effect on treatment of diarrhoea (RR 1·56, 95% CI 1·04, 2·34, p=0·030). CHWs provided the highest levels of appropriate treatment compared to other providers. However, differences in appropriate treatment were at health facilities and pharmacies, with CHW appropriate treatment the same across the arms. The rate of CHW attrition in both intervention arms was less than half that of the control arm; adjusted risk difference mHealth arm -4·42% (95% CI -8·54, -0·29, p=0·037) and VHC arm -4·75% (95% CI -8·74, -0·76, p=0·021). Interpretation: Appropriate treatment by CHWs was encouragingly high across arms. The inSCALE mHealth and VHC interventions have the potential to reduce CHW attrition and improve the treatment of sick children, but not through the hypothesised mechanisms of improved CHW utilization and treatment. Trial Registration: ClinicalTrials.gov (NCT01972321). Funding: Bill & Melinda Gates Foundation and UK DFID Declaration of Interest: We declare no competing interests Ethical Approval: The inSCALE trial, registered as NCT01972321, was approved by Makerere University Institutional Review Board, the Uganda National Council of Science and Technology (ref. HS 958), and London School of Hygiene & Tropical Medicine Ethics Committee in the UK (ref. 5762). Oral consent for the random allocation of districts to intervention or control groups was obtained from the sub-county leadership. Individual written informed consent was obtained from the caregiver for baseline and follow up data collection after explaining the purpose of the interview. Participants were free to decline the interview at any time.
Published: 2023

10. Pre-Hospital Antiplatelet Therapy for STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

Author: Serge Korjian, Christopher B. Granger, Arnoud W J van 't Hof, Jurriën M. ten Berg, C. Michael Gibson, Enrico Fabris, Barry S. Coller, Fabris, E., Korjian, S., Coller, B. S., Ten Berg, J. M., Granger, C. B., Gibson, C. M., and Van 'T Hof, A. W. J.
Subjects: Emergency Medical Services, Percutaneous, Time Factors, medicine.medical_treatment, PRIMARY PCI, PRIMARY ANGIOPLASTY, glycoprotein IIb/IIIa, 030204 cardiovascular system & hematology, antiplatelet therapy, DOUBLE-BLIND, 0302 clinical medicine, P2Y12, Risk Factors, inhibitors, ST-SEGMENT ELEVATION, 030212 general & internal medicine, Myocardial infarction, coronary reperfusion, Hematology, P2Y, inhibitor, Treatment Outcome, myocardial infarction, Human, medicine.medical_specialty, Time Factor, Ischemia, 12, pre-hospital, RUC-4, selatogrel, STEMI, Hemorrhage, Humans, Platelet Aggregation Inhibitors, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, Article, 03 medical and health sciences, IIB-IIIA INHIBITORS, IIIa, medicine, In patient, cardiovascular diseases, Intensive care medicine, Emergency Medical Service, business.industry, Platelet Aggregation Inhibitor, Risk Factor, ELEVATION MYOCARDIAL-INFARCTION, Percutaneous coronary intervention, medicine.disease, (12), EMERGENCY-DEPARTMENT, Review article, Pharmacodynamics, PLATELET-AGGREGATION, glycoprotein IIb, CLOPIDOGREL PRETREATMENT, business, TASK-FORCE
Abstract: Early recanalization of the infarct-related artery to achieve myocardial reperfusion is the primary therapeutic goal in patients with ST-elevation myocardial infarction (STEMI). To decrease the duration of ischaemia, continuous efforts have been made to improve pre-hospital treatment and to target the early period after symptom onset. In this period the platelet content of the fresh coronary thrombus is maximal and the thrombi are dynamic, and thus more susceptible to powerful antiplatelet agents. There have been substantial advances in antiplatelet therapy in the last three decades with several classes of oral and intravenous antiplatelet agents with different therapeutic targets, pharmacokinetics, and pharmacodynamic properties. New parenteral drugs achieve immediate inhibition of platelet aggregation, and fast and easy methods of administration may create the opportunity to bridge the initial gap in platelet inhibition observed with oral P2Y12 inhibitors. Moreover, potential future management of STEMI could directly involve patients in the process of care with self-administered antiplatelet agents designed to achieve rapid reperfusion. However, the potential anti-ischaemic benefits of potent antiplatelet agents will need to be balanced against their risk of increased bleeding. This study presents a comprehensive and updated review of pre-hospital antiplatelet therapy among STEMI patients undergoing primary percutaneous intervention and explores new therapies under development.
Published: 2021

11. A known unknown? Pharmacological prevention of venous thromboembolism in nursing home residents

Author: Steffie H. A. Brouns, Jos M. G. A. Schols, Arina J. ten Cate-Hoek, Hugo ten Cate, Bart Spaetgens, Renée A. G. Brüggemann, Teba Alnima, Nordin M J Hanssen, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, Amsterdam Gastroenterology Endocrinology Metabolism, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), Interne Geneeskunde, RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, MUMC+: HVC Trombosezorg (8), MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: HVC Pieken Trombose (9), and RS: Carim - B04 Clinical thrombosis and Haemostasis
Subjects: medicine.medical_specialty, PULMONARY-EMBOLISM, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], MEDLINE, PRIMARY THROMBOPROPHYLAXIS, MULTICENTER, GUIDELINES, PROPHYLAXIS, Risk Factors, medicine, Humans, DEEP-VEIN THROMBOSIS, Intensive care medicine, Aged, Netherlands, RISK, business.industry, Anticoagulants, Venous Thromboembolism, MOLECULAR-WEIGHT HEPARIN, medicine.disease, Pulmonary embolism, Nursing Homes, Geriatrics and Gerontology, Nursing homes, business, Venous thromboembolism
Abstract: Contains fulltext : 245942.pdf (Publisher’s version ) (Open Access)
Published: 2021

12. Antithrombotic therapy in high-risk patients after percutaneous coronary intervention; study design, cohort profile and incidence of adverse events

Author: J. M. ten Berg, H. ten Cate, Yvonne M. C. Henskens, P.E.J. van der Meijden, A. W. J. van ’t Hof, Renske H. Olie, Leo Veenstra, Minka J A Vries, Interne Geneeskunde, MUMC+: HVC Pieken Trombose (9), RS: Carim - B04 Clinical thrombosis and Haemostasis, Biochemie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H01 Clinical atrial fibrillation, Cardiologie, Faculteit FHML Centraal, MUMC+: DA CDL Algemeen (9), MUMC+: MA Alg Interne Geneeskunde (9), and MUMC+: HVC Trombosezorg (8)
Subjects: medicine.medical_specialty, Prasugrel, medicine.medical_treatment, Coronary artery disease, VALIDATION, Percutaneous coronary intervention, Anticoagulation, Antithrombotic, medicine, PRASUGREL, ARTERY-DISEASE, TREATMENT PLATELET REACTIVITY, business.industry, Antiplatelet therapy, Bleeding, DUAL ANTIPLATELET THERAPY, medicine.disease, Clopidogrel, BLEEDING SCORE, DEFINITION, CLOPIDOGREL, Cohort, Emergency medicine, Original Article, Antithrombotic treatment, IMPLANTATION, Cardiology and Cardiovascular Medicine, business, CONSENSUS, Ticagrelor, medicine.drug, Cohort study
Abstract: Background Patients with multiple clinical risk factors are a complex group in whom both bleeding and recurrent ischaemic events often occur during treatment with dual/triple antithrombotic therapy after percutaneous coronary intervention. Decisions on optimal antithrombotic treatment in these patients are challenging and not supported by clear guideline recommendations. A prospective observational cohort study was set up to evaluate patient-related factors, platelet reactivity, genetics, and a broad spectrum of biomarkers in predicting adverse events in these high-risk patients. Aim of the current paper is to present the study design, with a detailed description of the cohort as a whole, and evaluation of bleeding and ischaemic outcomes during follow-up, thereby facilitating future research questions focusing on specific data provided by the cohort. Methods We included patients with ≥ 3 predefined risk factors who were treated with dual/triple antithrombotic therapy following PCI. We performed a wide range of haemostatic tests and collected all ischaemic and bleeding events during 6–12 months follow-up. Results We included 524 high-risk patients who underwent PCI within the previous 1–2 months. All patients used a P2Y12 inhibitor (clopidogrel n = 388, prasugrel n = 61, ticagrelor n = 75) in combination with aspirin (n = 397) and/or anticoagulants (n = 160). Bleeding events were reported by 254 patients (48.5%), necessitating intervention or hospital admission in 92 patients (17.5%). Major adverse cardiovascular events (myocardial infarction, stroke, death) occurred in 69 patients (13.2%). Conclusion The high risk for both bleeding and ischaemic events in this cohort of patients with multiple clinical risk factors illustrates the challenges that the cardiologist faces to make a balanced decision on the optimal treatment strategy. This cohort will serve to answer several future research questions about the optimal management of these patients on dual/triple antithrombotic therapy, and the possible value of a wide range of laboratory tests to guide these decisions.
Published: 2021

13. A BROADER APPEAL: Destinations raise their game and offer amenities to appeal to new audiences

Author: Saylor, Ten
Subjects: Tourism, Convention bureaus, Hotels and motels, Travelers, Tourism promotion, Banks (Finance), Marketing, Blogs, Video recordings, Business, Business, regional
Abstract: Art, wellness and special amenities that appeal to frequent business and leisure travelers --and local residents --are the leading trends in destination marketing, designed to attract a new range of [...]
Published: 2019

14. Hierarchical Maximum Likelihood Parameter Estimation for Cumulative Prospect Theory: Improving the Reliability of Individual Risk Parameter Estimates

Author: Murphy, Ryan O. and Brincke, Robert H.W. ten
Subjects: Psychological research, Decision-making -- Psychological aspects, Individual differences -- Research, Risk-taking (Psychology) -- Measurement, Business, general, Business
Abstract: An individual's tolerance of risk can be quantified by using decision models with tuned parameters that maximally fit a set of risky choices the individual has made. A goal of this model fitting procedure is to identify parameters that correspond to stable underlying risk preferences. These preferences can be modeled as an individual difference, indicating a particular decision maker's tastes and willingness to accept risk. Using hierarchical statistical methods, we show significant improvements in the reliability of individual risk preference parameter estimates over other common methods for cumulative prospect theory. This hierarchical procedure uses population-level information (in addition to an individual's choices) to break 'ties' (or near ties) in the fit quality for sets of possible risk preference parameters. By breaking these statistical ties in a sensible way, researchers can avoid overfitting choice data and thus more resiliently measure individual differences in people's risk preferences. History: Accepted by Yuval Rottenstreich, judgment and decision making. Keywords: measuring risk preferences * cumulative prospect theory * decision making under risk * hierarchical parameter estimation * individual differences * risk profile * reliability, 1. Introduction People must often make choices among a number of different options for which the outcomes are not certain. Such choices are referred to as risky when the options [...]
Published: 2018
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15. A Meta-Analysis of the Effectiveness of EMDR and TF-CBT in Reducing Trauma Symptoms and Externalizing Behavior Problems in Adolescents

Author: Lotte ten Thije, Larissa M. Hoogsteder, Geert Jan J. M. Stams, Eveline E. Schippers, APH - Mental Health, and Psychiatry
Subjects: Adolescent, Eye Movement Desensitization Reprocessing, Behavioral therapy, Treatment as usual, Pathology and Forensic Medicine, Stress Disorders, Post-Traumatic, Arts and Humanities (miscellaneous), Independent samples, Medicine, Humans, 0501 psychology and cognitive sciences, Applied Psychology, Problem Behavior, Cognitive Behavioral Therapy, business.industry, 050901 criminology, 05 social sciences, Trauma treatment, Individual risk factors, Meta-analysis, Trauma symptoms, 0509 other social sciences, business, 050104 developmental & child psychology, Clinical psychology
Abstract: This multi-level meta-analysis tested if evidence-based trauma treatment was effective in reducing trauma symptoms and externalizing behavior problems in adolescents. Based on eight independent samples and 75 effect sizes, results indicated that Trauma Focused-Cognitive Behavioral Therapy (TF-CBT) and Eye Movement Desensitization Reprocessing (EMDR) had a large and significant overall effect ( d = 0.909) on reducing trauma symptoms and externalizing behavior problems. Trauma treatment significantly decreased trauma symptoms (large effect) and externalizing behavior problems (medium effect). Age and type of control group moderated treatment effects. Treatment was more effective in older adolescents. Trauma treatment for adolescents with externalizing behavior problems had a larger effect compared to no treatment, but not compared to treatment as usual. It seems important to provide a broad treatment offer for adolescents with severe externalizing behavior problems, in which, besides trauma treatment, attention is paid to reducing relevant individual risk factors for behavior problems.
Published: 2022

16. Treat-to-target in axial spondyloarthritis: an observational study in daily practice

Author: Esther Beckers, Annelies Boonen, Astrid van Tubergen, Casper Webers, Harald E. Vonkeman, Peter M. ten Klooster, M. Efde, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Interne Geneeskunde, MUMC+: MA Reumatologie (9), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), and Psychology, Health & Technology
Subjects: medicine.medical_specialty, treat-to-target, netherlands, PROGRESSION, clinical decision making, Severity of Illness Index, RECOMMENDATIONS, Rheumatology, Internal medicine, Daily practice, ankylosing spondylitis, medicine, MANAGEMENT, Humans, DISEASE-ACTIVITY SCORE, Spondylitis, Ankylosing, Pharmacology (medical), In patient, health care decision making, Axial spondyloarthritis, Ankylosing spondylitis, did not receive therapy or drug, Patient registry, business.industry, c-reactive protein measurement, ANKYLOSING-SPONDYLITIS, Treat to target, spondyloarthritis, medicine.disease, RHEUMATOID-ARTHRITIS, C-Reactive Protein, spondylarthritis, disease management, disease remission, Observational study, internet, business, Inactive disease, COLLECTION, Axial Spondyloarthritis
Abstract: Objectives To evaluate the extent to which internationally agreed treat-to-target recommendations were applied in clinical practice in patients with axial spondyloarthritis. Methods Data were used from a web-based patient registry for monitoring SpA in daily practice in the Netherlands. The extent to which treat-to-target was applied was evaluated through four indicators: the proportion of patients (i) with ≥1 Ankylosing Spondylitis Disease Activity Score (ASDAS) assessed during a 1-year period, (ii) having inactive disease/low disease activity (i.e. ASDAS Results In 185 out of 219 patients (84%), disease activity was monitored with ≥1 ASDAS during a 1-year period, of whom 71 (38%) patients had a score below the target (ASDAS Conclusions Treat-to-target was applied to a limited extent in clinical practice in patients with axial spondyloarthritis. Available disease activity scores seemed not to be used for determining the frequency of re-evaluation nor treatment adaptation.
Published: 2022

17. Delay-Aware Admission Control and Beam Allocation for 5G Functional Split Enhanced Millimeter Wave Wireless Fronthaul Networks

Author: Chun Hao Fang, Li-Hsiang Shen, Kai-Ten Feng, and Tun Ping Huang
Subjects: business.industry, Computer science, Applied Mathematics, Admission control, Computer Science Applications, Extremely high frequency, Wireless, Resource management, Quality of experience, Electrical and Electronic Engineering, business, Beam (structure), 5G, Computer network, C-RAN
Published: 2022

18. Inter-Rater Agreement of the Classification of Intraoperative Adverse Events (ClassIntra) in Abdominal Surgery

Author: R.P.G ten Broek, Salome Dell-Kuster, P Krielen, M. Stommel, L. Gawria, Rachel Rosenthal, and H. van Goor
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Incidence (epidemiology), medicine.medical_treatment, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, Cohen's kappa, Laparotomy, Cohort, Medicine, business, Complication, Laparoscopy, Adverse effect, Abdominal surgery
Abstract: Objective and summary of background data Adverse events in surgical patients can occur pre-operatively, intra-operatively and post-operatively. Universally accepted classification systems are not yet available for intra-operative adverse events (iAEs). ClassIntra, has recently been developed and validated as a tool for grading iAEs that occur between skin incision and skin closure irrespective of the origin, i.e. surgery, anesthesia or organizational. The aim of this study is to assess the inter-rater agreement of ClassIntra and assess its predictive value for post-operative complications in elective abdominal surgery. Methods This study is a secondary use of data from the LAParotomy or LAParoscopy and ADhesiolysis (LAPAD) study, with detailed data on incidence and management of intra-operative and post-operative complications. Data were collected in a cohort of elective abdominal surgeries. Two teams graded all recorded events in the LAPAD study according to ClassIntra. Cohen's Kappa coefficient was calculated to determine inter-rater agreement. Uni- and multivariable linear regression was used to assess the predictive value of the ClassIntra grades for post-operative complications. Results IAEs were rated in 333/755 (44%) surgeries by team 1, and in 324/755 (43%) surgeries by team 2. Cohen's kappa coefficient for ClassIntra grades was 0.87 (95% CI 0.84-0.90). Discrepancies in grading were most frequent for intra-operative bleeding and adhesions' associated injuries. At least one post-operative complication was observed in 278 (37%) patients. The risk of a post-operative complications increased with every increase in severity grade of ClassIntra. Intra-operative hypotension (mean difference (MD) 23.41, 95% CI 12.93 - 33.90) and other organ injuries (MD 18.90, 95% CI -4.22 - 42.02) were the strongest predictors for post-operative complications. Conclusions ClassIntra has an almost perfect inter-rater agreement for the classification of iAEs. An increasing grade of ClassIntra was associated with a higher incidence of post-operative complications. Discrepancies in grading related to common complications in abdominal procedures mostly consisted of intra-operative bleeding and adhesion-related injuries. Grading of interoperative events in abdominal surgery might further improve by consensus regarding the definitions of a number of frequent events.
Published: 2023

19. Five versus seven days of nitrofurantoin for urinary tract infections in women with diabetes: a retrospective cohort study

Author: Theo J M Verheij, Cornelis H. van Werkhoven, Kelly D. Hendriks-Spoor, Thijs ten Doesschate, Julia W. Dorigo-Zetsma, and Floor L. Wille
Subjects: Microbiology (medical), medicine.medical_specialty, business.industry, Urinary system, Significant difference, Anti-Infective Agents, Urinary, Retrospective cohort study, General Medicine, medicine.disease, Treatment failure, Infectious Diseases, Risk groups, Nitrofurantoin, Diabetes mellitus, Internal medicine, Urinary Tract Infections, Diabetes Mellitus, Humans, Medicine, Female, Medical prescription, business, Retrospective Studies, medicine.drug
Abstract: Objective To compare the effectiveness of five versus seven days of nitrofurantoin treatment for urinary tract infection (UTI) in diabetic women. Methods Data were collected retrospectively from Dutch general practitioners between 2013 and 2020. Nitrofurantoin prescriptions with a duration of five (5DN) or seven days (7DN) in women with diabetes were included. Inverse propensity weighting (IPW) was performed to calculate adjusted risk differences (RD) for treatment failure within 28 days. Secondary outcomes were 14-day treatment failure, severe treatment failure, and 28-day treatment failure in defined risk groups. Results Nitrofurantoin was prescribed in 6866 episodes, 3247 (47,3%) episodes with 5DN and 3619 (52,7%) episodes with 7DN. Patients in the 7DN group had more co-morbidities, more diabetes-related complications and were more insulin-dependent. There were 517/3247 (15.9%) failures in the 5DN group versus 520/3619 (14.4%) in the 7DN group. The adjusted RD for failure within 28 days was 1.4% (95% CI -0.6 to 3.4). Conclusion We found no clinically significant difference in treatment failure in diabetic women with UTI treated either five or seven days with nitrofurantoin within 28 days. A 5-day treatment should be considered to reduce cumulative nitrofurantoin exposure in DM patients.
Published: 2022

20. Performance of 3 Composite Measures for Disease Activity in Peripheral Spondyloarthritis

Author: Esther Beckers, Annelies Boonen, Marin Been, Peter M. ten Klooster, Astrid van Tubergen, Harald E. Vonkeman, Casper Webers, Psychology, Health & Technology, Interne Geneeskunde, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, MUMC+: MA Reumatologie (9), and MUMC+: MA Med Staf Artsass Interne Geneeskunde (9)
Subjects: medicine.medical_specialty, Spondyloarthropathy, Concordance, Immunology, Concurrent validity, Severity of Illness Index, Psoriatic arthritis, Rheumatology, Quality of life, Internal medicine, Psoriasis, Outcome Assessment, Health Care, medicine, MANAGEMENT, Humans, Immunology and Allergy, CRITERIA, Spondylitis, Ankylosing, 22/1 OA procedure, TREATMENT RECOMMENDATIONS, spondyloarthropathy, outcome assessment, disease activity score, INDEX, psoriatic arthritis, Ankylosing spondylitis, HEALTH-STATUS, INSTRUMENT, business.industry, Arthritis, Psoriatic, ANKYLOSING-SPONDYLITIS, medicine.disease, Concomitant, PSORIATIC-ARTHRITIS, Quality of Life, ACTIVITY SCORE ASDAS, business
Abstract: ObjectiveTo investigate concurrent validity and discrimination of the Disease Activity Index for Psoriatic Arthritis (DAPSA) score, Psoriatic Arthritis Disease Activity Score (PASDAS), and Ankylosing Spondylitis Disease Activity Score (ASDAS) in peripheral spondyloarthritis (pSpA) in clinical practice.MethodsData from a Dutch registry for SpA (SpA-Net) were used. Predefined hypotheses on concurrent validity of the composite measures with 15 other outcome measures of disease activity, physical function, and health-related quality of life were tested. Concurrent validity was considered acceptable if ≥ 75% of the hypotheses were confirmed. Discrimination was assessed by stratifying patients in DAPSA, PASDAS, and ASDAS predefined disease activity states and studying mean differences in health outcomes by 1-way ANOVA. Further, the concordance in disease activity states was determined. All analyses were repeated in subgroups with and without psoriasis (PsO).ResultsDAPSA, PASDAS, and ASDAS scores were available for 191, 139, and 279 patients with pSpA, respectively. The concurrent validity and discrimination of all composite measures were acceptable, as the strength of correlations were as hypothesized in ≥ 75% of the studied correlations. With increasing disease activity states, scores in nearly all outcome measures worsened significantly. The DAPSA, PASDAS, and ASDAS classified 22%, 56%, and 48% of the patients, respectively, in the 2 highest disease activity states. Stratified analyses for concomitant PsO revealed no relevant subgroup differences.ConclusionThe performance of DAPSA, PASDAS, and ASDAS in pSpA was acceptable, and independent of concomitant PsO. Due to discrepancy in classification, the validity of existing thresholds for disease activity states warrants further study in pSpA.
Published: 2022

21. Implementation of Secure Sampled Value (SeSV) Messages in Substation Automation System

Author: Sungsoo Choi, Soon-Woo Lee, Chee-Wooi Ten, Ramya Karnati, and Junho Hong
Subjects: Authentication, Network packet, Computer science, business.industry, 020208 electrical & electronic engineering, Control (management), Process (computing), Energy Engineering and Power Technology, Value (computer science), 020206 networking & telecommunications, 02 engineering and technology, Process automation system, Automation, 0202 electrical engineering, electronic engineering, information engineering, Message authentication code, Electrical and Electronic Engineering, business, Computer network
Abstract: IEC61850 is the mainstream of the development for substation automation. This paper presents a practical consideration and analysis for implementing a secure sampled measured value (SeSV) message in substation automation system. Due to the lack of security features in the standard, IEC Working Group 15 of Technical Committee 57 published IEC62351 on security for IEC61850 profiles. However, the use of authentication methods for SV based on IEC62351 standards are still not integrated, and computational capabilities and performance are not validated and tested with commercial grade equipment. Hence, this paper shows the performance of security feature enabled SeSV packets transmitted between protection and control devices by appending a message authentication code (MAC) to the extended IEC61850 packets. A prototype implementation on a low cost commodity embedded system has proved that the MAC-enabled SV message can fully secure the process bus communication in the digital substation with negligible time delay.
Published: 2022

22. Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

Author: Wouter ten Voorde, Robert Rissmann, Michelle Osse, Manon A. A. Jansen, G. Feiss, Edwin Florencia, Mascha Schoonakker, Floris C. van Hindevoort, Matthijs Moerland, Erik Lubberts, Pieter W Hameeteman, Thomas P. Buters, Jeffrey Damman, Amit Patel, Iris M. E. Jansen, Marieke L. de Kam, Jacobus Burggraaf, Simon Yona, Derek W. Gilroy, Hendrika W. Grievink, Dermatology, Rheumatology, and Pathology
Subjects: Lipopolysaccharides, Male, Necrosis, Lipopolysaccharide, Erythema, medicine.medical_treatment, Inflammation, Pharmacology, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, In vivo, Medicine, Humans, Pharmacology (medical), medicine.diagnostic_test, business.industry, Interleukin-6, Tumor Necrosis Factor-alpha, Interleukin, Healthy Volunteers, Cytokine, chemistry, Skin biopsy, Cytokines, medicine.symptom, business
Abstract: Aims: Whereas intravenous administration of Toll-like receptor 4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intradermal LPS response in healthy volunteers, and as such qualify the method as local inflammation model for clinical pharmacology studies. Methods: Eighteen healthy male volunteers received 2 or 4 intradermal 5 ng LPS injections and 1 saline injection on the forearms. The LPS response was evaluated by noninvasive (perfusion, skin temperature and erythema) and invasive assessments (cellular and cytokine responses) in skin biopsy and blister exudate. Results: LPS elicited a visible response and returned to baseline at 48 hours. Erythema, perfusion and temperature were statistically significant (P Discussion: Intradermal LPS administration in humans causes an acute, localized and transient inflammatory reaction that is well-tolerated by healthy volunteers. This may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory investigational compounds in proof of pharmacology studies.
Published: 2022

23. X-Linked Retinoschisis

Author: Camiel J. F. Boon, Julie De Zaeytijd, Mary J. van Schooneveld, Maria M. van Genderen, Ralph J. Florijn, Bart P. Leroy, Carel B. Hoyng, Paul A. Sieving, Alberta A H J Thiadens, Sophie Walraedt, Jeannette Ossewaarde-van Norel, Magda A. Meester-Smoor, Leo C. Hahn, Birgit I. Lissenberg-Witte, Arthur A.B. Bergen, Jacoline B. ten Brink, Elfride De Baere, Nieneke L. Wesseling, Caroline Van Cauwenbergh, Caroline C W Klaver, Roselie M. Diederen, L. Ingeborgh van den Born, and Ine Strubbe
Subjects: Pediatrics, medicine.medical_specialty, Visual acuity, genetic structures, medicine.diagnostic_test, business.industry, Visual impairment, Fundus photography, Retinoschisis, Retrospective cohort study, medicine.disease, Ophthalmoscopy, Ophthalmology, medicine, Medical history, medicine.symptom, business, Electroretinography
Abstract: Purpose To describe the natural course, phenotype and genotype of patients with X-linked retinoschisis (XLRS). Design Retrospective cohort study. Participants Three hundred forty patients with XLRS from 178 presumably unrelated families. Methods This multicenter, retrospective cohort study reviewed medical records of XLRS patients for medical history, symptoms, visual acuity (VA), ophthalmoscopy, full-field electroretinography and retinal imaging (fundus photography, spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence). Main Outcome Measures Age at onset, age of diagnosis, severity of visual impairment, annual visual decline, electroretinogram and imaging findings. Results In total, 340 patients were included with a mean follow-up time of 13.2 years (range, 0–50.1 years). The median age to reach mild visual impairment and low vision was 12 and 25 years, respectively. Severe visual impairment and blindness were predominantly observed in patients above 40 years old, with a predicted prevalence of 35% and 25% at the age of 60, respectively. The VA increased slightly in the first two decades of life, and subsequently transitioned in to an average annual decline of 0.44% (P A (p.(Glu72Lys) (101 subjects, 29.7%) and a deletion of exon 3 (38 subjects, 11.2%). Conclusion A large variability in phenotype and natural course of XLRS was seen in this study. In most patients, XLRS showed a slow deterioration starting in the second decade of life, suggesting an optimal window of opportunity for treatment within the first three decades of life. The integrity of EZ as well as the PROS length on SD-OCT may be important in choosing optimal candidates for treatment, and as potential structural endpoints in future therapeutic studies. No clear genotype-phenotype correlation was found.
Published: 2022

24. Nitrofurantoin 100 mg versus 50 mg prophylaxis for urinary tract infections

Author: Thijs ten Doesschate, Anouk E. Muller, Irene A.M. Groenewegen, Kelly Hendriks, T.N. Platteel, Suzanne E. Geerlings, Andy I.M. Hoepelman, Evelien C. van der Hout, Cornelis H. van Werkhoven, Marc J. M. Bonten, Medical Microbiology & Infectious Diseases, Infectious diseases, AII - Infectious diseases, and APH - Quality of Care
Subjects: 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Nausea, Urinary system, 030106 microbiology, Anti-Infective Agents, Urinary, urologic and male genital diseases, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Interquartile range, Internal medicine, medicine, Humans, 030212 general & internal medicine, Retrospective Studies, Pneumonitis, First episode, Urinary tract infection, Prophylaxis, business.industry, Hazard ratio, General Medicine, Primary care, medicine.disease, female genital diseases and pregnancy complications, Infectious Diseases, Nitrofurantoin, Urinary Tract Infections, Female, medicine.symptom, business, Cohort study, medicine.drug
Abstract: Objectives: Guidelines do not distinguish between 50 mg or 100 mg nitrofurantoin as daily prophylaxis for recurrent urinary tract infection (UTI), although 50 mg might have a better safety profile. Our objective was to compare the effectiveness and safety of both regimens. Methods: Data were retrospectively collected from 84 Dutch GP practices between 2013 and 2020. Nitrofurantoin prescriptions of 100 mg and 50 mg every 24 hours in women were included. Cox proportional hazard regression analysis was used to calculate hazard ratios on first episode of UTI, pyelonephritis and (adverse) events. Patients were followed for the duration of consecutive repeated prescriptions, assuming non-informative right censoring, up to 1 year. Results: Nitrofurantoin prophylaxis was prescribed in 1893 patients. Median lengths of follow up were 90 days (interquartile range (IQR) 37–179 days) for 100 mg (n = 551) and 90 days (IQR 30–146 days) for 50 mg (n = 1342) with few differences in baseline characteristics between populations. Under 100 mg and 50 mg, 82/551 (14.9%) and 199/1342 (14.8%) developed UTI and 46/551 (8.3%) and 81/1342 (6.0%) developed pyelonephritis, respectively. Adjusted HRs of 100 mg versus 50 mg were 1.01 (95% CI 0.78–1.30) on first UTI, 1.37 (95% CI 0.95–1.98) on first pyelonephritis episode, 1.82 (95% CI 1.20–2.74) on first consultation for cough, 2.68 for dyspnoea (95% CI 1.11–6.45) and 2.43 for nausea (95% CI 1.03–5.74). Conclusion: Daily prophylaxis for recurrent UTI with 100 mg instead of 50 mg nitrofurantoin was associated with an equivalent hazard on UTI or pyelonephritis, and a higher hazard on cough, dyspnoea and nausea. We recommend 50 mg nitrofurantoin as daily prophylaxis.
Published: 2022

25. A Novel Fairness Allocation Strategy With Minimum Mainlobe Interference for mmWave Networks

Author: Mohammad Talart, Li-Hsiang Shen, Chih-Min Yu, and Kai-Ten Feng
Subjects: Beamforming, Computer Networks and Communications, Computer science, business.industry, Quality of service, Throughput, Interference (wave propagation), Communications system, Precoding, Computer Science Applications, Hardware and Architecture, Signal Processing, Resource management, business, 5G, Information Systems, Computer network
Abstract: In the fifth generation (5G) communication system, millimeter wave (mmWave) technology brings superior capabilities such as higher capacity, lower latency, and flexible beamforming structure. The interference management strategies play an important role in mmWave beamforming networks to support the multi-beam operation and maximize the overall data rates for user equipments (UEs). Currently, most of existing research do not jointly consider designs including the mainlobe interference (MI) avoidance and resource blocks (RBs) fairness allocation. In this paper, a novel fairness allocation strategy is proposed to achieve the minimum MI and fair RB assignment for mmWave networks. To achieve the minimum MI, an MI mitigation (MIM) algorithm is designed to maximize the data rate for each UE. With the adaptive mini-timeslot design, the MIM algorithm can achieve MI cancellation for all UEs at each identical timeslot and beam. To combine MI mitigation and fairness for RB allocation among all UEs, the MIM-fairness allocation (MIM-FA) algorithm is also presented. Based on a novel mini-timeslot with designed multiple frames, the MIM-FA algorithm can simultaneously guarantee the fairness among all UEs and mitigate MI at each mini-timeslot for each beam. Additionally, the MIM-FA algorithm can be verified that it achieves the maximum user data rate with the identical number of RBs under the lowest number of frames. Simulation results validate that the proposed MIM and MIM-FA algorithms can provide higher data rate and better fairness for different scenarios compared to current state-of-the-art competitive approaches.
Published: 2022

26. CRB1-Associated Retinal Dystrophies

Author: Alberta A H J Thiadens, Carel B. Hoyng, Marta Fiocco, Magda A. Meester-Smoor, Maria M. van Genderen, Herman E Talsma, Camiel J. F. Boon, L. Ingeborgh van den Born, Jan Wijnholds, Jacoline B. ten Brink, Frans P.M. Cremers, Arthur A.B. Bergen, Mary J. van Schooneveld, Ralph J. Florijn, Xuan-Thanh-An Nguyen, Caroline C W Klaver, Nicoline E. Schalij-Delfos, Mays Talib, Netherlands Institute for Neuroscience (NIN), Ophthalmology, Human Genetics, ANS - Complex Trait Genetics, ARD - Amsterdam Reproduction and Development, and Epidemiology
Subjects: medicine.medical_specialty, Visual acuity, genetic structures, Nerve Tissue Proteins, Retina, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, Ophthalmology, Retinitis pigmentosa, Retinal Dystrophies, medicine, Electroretinography, Humans, Eye Proteins, medicine.diagnostic_test, business.industry, Fundus photography, Membrane Proteins, Retinal, Diabetic retinopathy, Macular dystrophy, medicine.disease, eye diseases, chemistry, Visual Field Tests, sense organs, medicine.symptom, Visual Fields, business, Microperimetry, Retinitis Pigmentosa, Tomography, Optical Coherence
Abstract: PURPOSE: To investigate the natural disease course of retinal dystrophies associated with crumbs cell polarity complex component 1 (CRB1) and identify clinical end points for future clinical trials. DESIGN: Single-center, prospective case series. METHODS: An investigator-initiated nationwide collaborative study that included 22 patients with CRB1-associated retinal dystrophies. Patients underwent ophthalmic assessment at baseline and 2 years after baseline. Clinical examination included best-corrected visual acuity (BCVA) using Early Treatment Diabetic Retinopathy Study charts, Goldmann kinetic perimetry (V4e isopter seeing retinal areas), microperimetry, full-field electroretinography, full-field stimulus threshold (FST), fundus photography, spectral-domain optical coherence tomography, and fundus autofluorescence imaging. RESULTS: Based on genetic, clinical, and electrophysiological data, patients were diagnosed with retinitis pigmentosa (19 [86%]), cone-rod dystrophy (2 [9%]), or isolated macular dystrophy (1 [5%]). Analysis of the entire cohort at 2 years showed no significant changes in BCVA (P = .069) or V4e isopter seeing retinal areas (P = .616), although signs of clinical progression were present in individual patients. Macular sensitivity measured on microperimetry revealed a significant reduction at the 2-year follow-up (P < .001). FST responses were measurable in patients with nonrecordable electroretinograms. On average, FST responses remained stable during follow-up. CONCLUSION: In CRB1-associated retinal dystrophies, visual acuity and visual field measures remain relatively stable over the course of 2 years. Microperimetry showed a significant decrease in retinal sensitivity during follow-up and may be a more sensitive progression marker. Retinal sensitivity on microperimetry may serve as a functional clinical end point in future human treatment trials for CRB1-associated retinal dystrophies.
Published: 2022

27. Discontinuation of anti-PD-1 monotherapy in advanced melanoma

Author: John B. A. G. Haanen, Maureen J.B. Aarts, Michel W.J.M. Wouters, Albert J. ten Tije, Astrid A M van der Veldt, Karijn P M Suijkerbuijk, Rozemarijn S. van Rijn, Alfons J.M. van den Eertwegh, Liesbeth C. de Wreede, Ellen Kapiteijn, Geke A. P. Hospers, Franchette W P J van den Berkmortel, Jacobus J.M. van der Hoeven, Gerard Vreugdenhil, Michiel C T van Zeijl, Jan-Willem B de Groot, Djura Piersma, Medical Oncology, Radiology & Nuclear Medicine, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Internal medicine, Medical oncology, CCA - Cancer Treatment and quality of life, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, and MUMC+: MA Medische Oncologie (9)
Subjects: Male, advanced melanoma, Cancer Research, medicine.medical_specialty, real-world, Skin Neoplasms, Programmed Cell Death 1 Receptor, Ipilimumab, Pembrolizumab, Stable Disease, SDG 3 - Good Health and Well-being, Internal medicine, Medicine, Humans, METASTATIC MELANOMA, Adverse effect, PEMBROLIZUMAB, Immune Checkpoint Inhibitors, Melanoma, Aged, Retrospective Studies, business.industry, Proportional hazards model, IPILIMUMAB, Hazard ratio, Middle Aged, medicine.disease, Prognosis, Discontinuation, Survival Rate, Oncology, Withholding Treatment, SURVIVAL, anti-PD-1, Female, immunotherapy, business, Progressive disease, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], medicine.drug, Follow-Up Studies, discontinuation
Abstract: Contains fulltext : 287666.pdf (Publisher’s version ) (Open Access) There is no consensus on the optimal treatment duration of anti-PD-1 for advanced melanoma. The aim of our study was to gain insight into the outcomes of anti-PD-1 discontinuation, the association of treatment duration with progression and anti-PD-1 re-treatment in relapsing patients. Analyses were performed on advanced melanoma patients in the Netherlands who discontinued first-line anti-PD-1 monotherapy in the absence of progressive disease (n = 324). Survival was estimated after anti-PD-1 discontinuation and with a Cox model the association of treatment duration with progression was assessed. At the time of anti-PD-1 discontinuation, 90 (28%) patients had a complete response (CR), 190 (59%) a partial response (PR) and 44 (14%) stable disease (SD). Median treatment duration for patients with CR, PR and SD was 11.2, 11.5 and 7.2 months, respectively. The 24-month progression-free survival and overall survival probabilities for patients with a CR, PR and SD were, respectively, 64% and 88%, 53% and 82%, 31% and 64%. Survival outcomes of patients with a PR and CR were similar when anti-PD-1 discontinuation was not due to adverse events. Having a PR at anti-PD-1 discontinuation and longer time to first response were associated with progression [hazard ratio (HR) = 1.81 (95% confidence interval, CI = 1.11-2.97) and HR = 1.10 (95% CI = 1.02-1.19; per month increase)]. In 17 of the 27 anti-PD-1 re-treated patients (63%), a response was observed. Advanced melanoma patients can have durable remissions after (elective) anti-PD-1 discontinuation.
Published: 2022

28. Maternal and fetal characteristics for predicting risk of Cesarean section following induction of labor

Author: D. Quach, Wentao Li, Miranda Davies-Tuck, K. W. M. Bloemenkamp, Ben W.J. Mol, M. Jozwiak, M. ten Eikelder, and Gynecological Oncology
Subjects: Adult, medicine.medical_specialty, Percentile, Bishop score, Cervix Uteri, Logistic regression, law.invention, Body Mass Index, Fetus, Randomized controlled trial, law, Predictive Value of Tests, Pregnancy, Risk Factors, Prenatal Diagnosis, Odds Ratio, Medicine, Birth Weight, Humans, Radiology, Nuclear Medicine and imaging, Labor, Induced, Randomized Controlled Trials as Topic, Labor, Obstetric, Radiological and Ultrasound Technology, business.industry, Vaginal delivery, Obstetrics, Cesarean Section, Area under the curve, Obstetrics and Gynecology, General Medicine, Odds ratio, Obstetric Labor Complications, Parity, Logistic Models, Reproductive Medicine, Female, business, Parity (mathematics), Maternal Age
Abstract: Objective: Induction of labor (IOL) is one of the most widely used obstetric interventions. However, one-fifth of IOLs result in Cesarean section (CS). We aimed to assess maternal and fetal characteristics that influence the likelihood of CS following IOL, according to the indication for CS. Methods: This was a secondary analysis of pooled data from four randomized controlled trials, including women undergoing IOL at term who had a singleton pregnancy and an unfavorable cervix, intact membranes and the fetus in cephalic presentation. The main outcomes of this analysis were CS for failure to progress (FTP) and CS for suspected fetal compromise (SFC). Restricted cubic splines were used to determine whether continuous maternal and fetal characteristics had a non-linear relationship with outcome. Optimal cut-offs for those characteristics with a non-linear pattern were determined based on the maximum area under the receiver-operating-characteristics curve. Adjusted odds ratios (aOR) were computed, using multivariable logistic regression analysis, for the associations between optimally categorized characteristics and outcome. Results: Of a total of 2990 women undergoing IOL, 313 (10.5%) had CS for FTP and 227 (7.6%) had CS for SFC. The risk of CS for FTP was increased in women aged 31–35 years compared with younger women (aOR, 1.51 (95% CI, 1.15–1.99)), in nulliparous compared with parous women (aOR, 8.07 (95% CI, 5.34–12.18)) and in Sub-Saharan African compared with Caucasian women (aOR, 2.09 (95% CI, 1.33–3.28)). Higher body mass index (BMI) increased incrementally the risk of CS for FTP (aOR, 1.06 (95% CI, 1.04–1.08)). High birth-weight percentile was also associated with an increased risk of CS due to FTP (aOR, 2.66 (95% CI, 1.74–4.07) for birth weight between the 80.0th and 89.9th percentiles and aOR, 4.08 (95% CI, 2.75–6.05) for birth weight ≥ 90th percentile, as compared with birth weight between the 20.0th and 49.9th percentiles). For CS due to SFC, higher maternal age (aOR, 1.09 (95% CI, 1.05–1.12)) and BMI (aOR, 1.05 (95% CI, 1.03–1.08)) were associated with an incremental increase in risk. The risk of CS for SFC was increased in nulliparous compared with parous women (aOR, 5.91 (95% CI, 3.76–9.28)) and in South Asian compared with Caucasian women (aOR, 2.50 (95% CI, 1.23–5.10)). Birth weight < 10.0th percentile increased significantly the risk of CS due to SFC (aOR, 1.93 (95% CI, 1.22–3.05)), as compared with birth weight between the 20.0th and 49.9th percentiles. Bishop score did not demonstrate a significant association with the risk of CS for FTP or for SFC. Conclusions: In women undergoing IOL, maternal age, BMI, parity, ethnicity and birth-weight percentile are predictors of CS due to FTP and of CS due to SFC, but the direction and magnitude of the associations differ according to the indication for CS. These characteristics should be considered in combination with the Bishop score to stratify the risk of CS for different indications in women undergoing IOL.
Published: 2022

29. 3-Month Enalapril Treatment in Pediatric Fontan Patients With Moderate to Good Systolic Ventricular Function

Author: Covadonga Terol Espinosa de los Monteros, Nico A. Blom, Arend D. J. ten Harkel, Lukas A.J. Rammeloo, J. Gert van Dijk, Lisette M. Harteveld, Mark G. Hazekamp, Irene M. Kuipers, Paediatric Cardiology, ACS - Heart failure & arrhythmias, APH - Methodology, and APH - Quality of Care
Subjects: Male, medicine.medical_specialty, Adolescent, Systole, medicine.drug_class, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Fontan Procedure, Vascular Stiffness, Enalapril, Internal medicine, Natriuretic Peptide, Brain, Ventricular Dysfunction, Natriuretic peptide, medicine, Humans, cardiovascular diseases, Child, Adverse effect, Exercise Tolerance, Ventricular function, business.industry, Plasma levels, medicine.disease, Peptide Fragments, Treatment Outcome, Blood pressure, Echocardiography, ACE inhibitor, Exercise Test, cardiovascular system, Cardiology, Arterial stiffness, Female, Hypotension, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Many Fontan patients with and without systolic ventricular dysfunction are being treated with angiotensin-converting enzyme (ACE) inhibitors, despite its effectiveness remaining unclear. In the present study, we evaluated the short-term effect of enalapril on exercise capacity, vascular and ventricular function in pediatric Fontan patients with moderategood systolic ventricular function. Fontan patients between 8 and 18 years with moderategood systolic ventricular function and without previous ACE inhibitor treatment were included and were treated with enalapril for 3 months. During the first 2 weeks, the dosage was titrated according to systolic blood pressure (SBP). Exercise tests, ventricular function assessed by echocardiography, arterial stiffness measurements, and plasma levels of N-terminal pro-B-type natriuretic peptide assessed before and after a 3-month enalapril treatment period was compared. A total of 28 Fontan patients (median age 13.9 years, 6 to 15 years after Fontan operation) completed the study with a mean dosage of 0.3 +/- 0.1 mg/ kg/d. A total of 6 patients (21 %) experienced a significant drop in SBP and 6 others (21%) experienced other adverse events. Enalapril treatment lowered the SBP (from 110 to 104 mmHg, p = 0.003) and levels of N-terminal pro-B-type natriuretic peptide (from 80 to 72 ng/L, p = 0.036). However, enalapril treatment did not improve exercise capacity, ventricular function, or arterial stiffness. In conclusion, short-term ACE inhibition has no beneficial effect in Fontan patients with moderate-good systolic ventricular function. (C) 2021 The Authors. Published by Elsevier Inc.
Published: 2022

30. Effects of surgery and general anaesthesia on sleep–wake timing: CLOCKS observational study

Author: M. W. Hollmann, Sarah E. Siegelaar, W. ten Hoope, A J G Meewisse, Benedikt Preckel, Wietse J. Eshuis, M. L. van Zuylen, D J Stenvers, Jeroen Hermanides, Anesthesiology, Graduate School, ANS - Neuroinfection & -inflammation, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Heart failure & arrhythmias, APH - Quality of Care, APH - Global Health, ACS - Microcirculation, ACS - Diabetes & metabolism, Endocrinology, and ACS - Amsterdam Cardiovascular Sciences
Subjects: Adult, Male, circadian rhythm, medicine.medical_specialty, Anesthesia, General, Dexamethasone, sleep–wake timing, Pittsburgh Sleep Quality Index, surgery, Circadian Clocks, Humans, Medicine, General anaesthesia, Postoperative Period, Prospective Studies, Circadian rhythm, Elective surgery, Prospective cohort study, Aged, business.industry, circadian timing system, Chronotype, anaesthesia, Middle Aged, Sleep in non-human animals, Surgery, Sleep Quality, Anesthesiology and Pain Medicine, Elective Surgical Procedures, Female, Observational study, business
Abstract: Surgery and general anaesthesia have the potential to disturb the body’s circadian timing system, which may affect postoperative outcomes. Animal studies suggest that anaesthesia could induce diurnal phase shifts, but clinical research is scarce. We hypothesised that surgery and general anaesthesia would result in peri-operative changes in diurnal sleep–wake patterns in patients. In this single-centre prospective cohort study, we recruited patients aged ≥18 years scheduled for elective surgery receiving ≥30 min of general anaesthesia. The Munich Chronotype Questionnaire and Pittsburgh Sleep Quality Index were used to determine baseline chronotype, sleep characteristics and sleep quality. Peri-operative sleeping patterns were logged. Ninety-four patients with a mean (SD) age of 52 (17) years were included; 56 (60%) were female. The midpoint of sleep (SD) three nights before surgery was 03.33 (55 min) and showed a phase advance of 40 minutes to 02.53 (67 min) the night after surgery (p
Published: 2022

31. Nationwide registry study on trends in localization techniques and reoperation rates in non-palpable ductal carcinoma in situ and invasive breast cancer

Author: Grard A. P. Nieuwenhuijzen, Theo J.M. Ruers, Robert-Jan Schipper, Bennie ten Haken, Yvonne E. van Riet, B. Schermers, Adri C. Voogd, Marie-Jeanne T. F. D. Vrancken Peeters, Nanobiophysics, TechMed Centre, Magnetic Detection and Imaging, RS: GROW - R1 - Prevention, RS: CAPHRI - R5 - Optimising Patient Care, and Epidemiologie
Subjects: Reoperation, medicine.medical_specialty, WIRE LOCALIZATION, SATISFACTION, Registry study, Breast surgery, medicine.medical_treatment, UT-Hybrid-D, Breast Neoplasms, Mastectomy, Segmental, Odds, Breast cancer, Fiducial Markers, medicine, Humans, Registries, Prospective cohort study, MARGINS, Aged, Netherlands, Retrospective Studies, LESIONS, business.industry, RADIOACTIVE SEED LOCALIZATION, Odds ratio, Middle Aged, Ductal carcinoma, medicine.disease, CONSERVING SURGERY, Carcinoma, Intraductal, Noninfiltrating, Cohort, Female, Surgery, Radiology, business
Abstract: Background There is a transition from wire-guided localization (WGL) of non-palpable breast cancer to other localization techniques. Multiple prospective studies have sought to establish superior clinical outcomes for radioactive-seed localization (RSL), but consistent and congruent evidence is missing. Methods In this study, female patients with breast cancer operated with breast-conserving surgery after tumour localization of a non-palpable breast cancer or ductal carcinoma in situ (DCIS) were included. The cohort was identified from the nationwide Netherlands Breast Cancer Audit conducted between 2013 and 2018. Trends in localization techniques were analysed. Univariable and multivariable analyses were performed to assess the association between the localization technique and the probability of a reoperation. Results A total of 28 370 patients were included in the study cohort. The use of RSL increased from 15.7 to 61.1 per cent during the study years, while WGL decreased from 75.4 to 31.6 per cent. The localization technique used (RSL versus WGL) was not significantly associated with the odds of a reoperation, regardless of whether the lesion was DCIS (odds ratio 0.96 (95 per cent c.i. 0.89 to 1.03; P = 0.281)) or invasive breast cancer (OR 1.02 (95 per cent c.i. 0.96 to 1.10; P = 0.518)). Conclusion RSL is rapidly replacing WGL as the preoperative localization technique in breast surgery. This large nationwide registry study found no association between the type of localization technique and the odds of having a reoperation, thus confirming the results of previous prospective cohort studies.
Published: 2022

32. Addition of an Fc-IgG induces receptor clustering and increases the in vitro efficacy and in vivo anti-tumor properties of the thrombospondin-1 type I repeats (3TSR) in a mouse model of advanced stage ovarian cancer

Author: Sarah K. Wootton, Simone ten Kortenaar, Jack Lawler, Jim Petrik, Madison Pereira, Lisa A. Santry, Byram W. Bridle, Kathy Matuszewska, Duncan Petrik, and Kin-Ming Lo
Subjects: CD36, Angiogenesis Inhibitors, Carcinoma, Ovarian Epithelial, Thrombospondin 1, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Animals, Humans, Medicine, Receptor, 030304 developmental biology, Ovarian Neoplasms, 0303 health sciences, Neovascularization, Pathologic, biology, business.industry, Obstetrics and Gynecology, medicine.disease, In vitro, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, Oncology, Apoptosis, Immunoglobulin G, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Receptor clustering, business, Ovarian cancer
Abstract: Objectives Tumor vasculature is structurally abnormal, with anatomical deformities, reduced pericyte coverage and low tissue perfusion. As a result of this vascular dysfunction, tumors are often hypoxic, which is associated with an aggressive tumor phenotype, and reduced delivery of therapeutic compounds to the tumor. We have previously shown that a peptide containing the thrombospondin-1 type I repeats (3TSR) specifically targets tumor vessels and induces vascular normalization in a mouse model of epithelial ovarian cancer (EOC). However, due to its small size, 3TSR is rapidly cleared from circulation. We now introduce a novel construct with the 3TSR peptide fused to the C-terminus of each of the two heavy chains of the Fc region of human IgG1 (Fc3TSR). We hypothesize that Fc3TSR will have greater anti-tumor activity in vitro and in vivo compared to the native compound. Methods Fc3TSR was evaluated in vitro using proliferation and apoptosis assays to investigate differences in efficacy compared to native 3TSR. In light of the multivalency of Fc3TSR, we also investigate whether it induces greater clustering of its functional receptor, CD36. We also compare the compounds in vivo using an orthotopic, syngeneic mouse model of advanced stage EOC. The impact of the two compounds on changes to tumor vasculature morphology was also investigated. Results Fc3TSR significantly decreased the viability and proliferative potential of EOC cells and endothelial cells in vitro compared to native 3TSR. High-resolution imaging followed by image correlation spectroscopy demonstrated enhanced clustering of the CD36 receptor in cells treated with Fc3TSR. This was associated with enhanced downstream signaling and greater in vitro and in vivo cellular responses. Fc3TSR induced greater vascular normalization and disease regression compared to native 3TSR in an orthotopic, syngeneic mouse model of advanced stage ovarian cancer. Conclusion The development of Fc3TSR which is greater in size, stable in circulation and enhances receptor activation compared to 3TSR, facilitates its translational potential as a therapy in the treatment of metastatic advanced stage ovarian cancer.
Published: 2022

33. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author: Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. Cheewatanakornkul, T. Laksomya, S. Pattanaprichakul, T. Chantrarat, S. Rungaramsin, S. Silaruks, W. Wongcharoen, K. Siriwattana, K. Likittanasombat, P. Katekangplu, W. Boonyapisit, D. Cholsaringkarl, B. Chatlaong, P. Chattranukulchai, Y. Santanakorn, P. Hutayanon, P. Khunrong, T. Bunyapipat, S. Jai-Aue, P. Kaewsuwanna, P. Bamungpong, S. Gunaparn, S. Hongsuppinyo, R. Inphontan, R. Khattaroek, K. Khunkong, U. Kitmapawanont, C. Kongsin, B. Naratreekoon, S. Ninwaranon, J. Phangyota, A. Phrommintikul, P. Phunpinyosak, K. Pongmorakot, S. Poomiphol, N. Pornnimitthum, S. Pumprueg, S. Ratchasikaew, K. Sanit, K. Sawanyawisuth, B. Silaruks, R. Sirichai, A. Sriwichian, W. Suebjaksing, P. Sukklad, T. Suttana, A. Tangsirira, O. Thangpet, W. Tiyanon, Y. Vorasettakarnkij, T. Wisaratapong, W. Wongtheptien, A. Wutthimanop, S. Yawila, A. Oto, A. Altun, I. Ozdogru, K. Ozdemir, O. Yilmaz, A. Aydinlar, M.B. Yilmaz, E. Yeter, Z. Ongen, M. Cayli, H. Pekdemir, M. Ozdemir, M. Sucu, T. Sayin, M. Demir, H. 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Subjects: Registrie, Male, Time Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, 030204 cardiovascular system & hematology, Electrocardiography, 0302 clinical medicine, Risk Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Incidence, India, Prevalence, Prognosis, Prospective Studies, Survival Rate, Thromboembolism, Registries, Risk Assessment, Medicine, 030212 general & internal medicine, Prospective cohort study, Incidence (epidemiology), cardiovascular system, medicine.symptom, Cardiology and Cardiovascular Medicine, Risk assessment, Human, medicine.medical_specialty, Time Factor, RD1-811, Prognosi, Follow-Up Studie, 03 medical and health sciences, Internal medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, Risk factor, Survival rate, Fibrillation, business.industry, Risk Factor, ta3121, medicine.disease, Clinical trial, Prospective Studie, RC666-701, Surgery, Clinical and Preventive Cardiology, business
Abstract: Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
Published: 2018

34. Postinterventional antithrombotic management after venous stenting of the iliofemoral tract in acute and chronic thrombosis: A systematic review

Author: Arina J. ten Cate-Hoek, Pascale Notten, and Hugo ten Cate
Subjects: endovascular treatment, medicine.medical_specialty, ASPIRATION THROMBECTOMY, OCCLUSION, POSTTHROMBOTIC SYNDROME, MEDLINE, Review Article, Iliac Vein, 030204 cardiovascular system & hematology, deep vein thrombosis, CATHETER-DIRECTED THROMBOLYSIS, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Occlusion, Antithrombotic, Humans, Medicine, Vascular Patency, vascular patency, Venous Thrombosis, therapy, COMPRESSION SYNDROME, business.industry, Postthrombotic syndrome, Original Articles, Hematology, Femoral Vein, deep-vein thrombosis, trial, medicine.disease, Thrombosis, antithrombotic agents, placement, Surgery, THROMBOSIS, venous stenting, Treatment Outcome, Clinical research, Stents, business, Venous thromboembolism
Abstract: Venous stenting has become a common treatment option for central deep venous outflow obstructions and postthrombotic syndrome. Following successful recanalization and stenting, stent patency is endangered by in‐stent thrombosis and recurrent venous thromboembolism. Antithrombotic therapy might reduce patency loss. This systematic review summarizes the literature on antithrombotic therapy following (post)thrombotic venous stenting. A systematic PubMed, MEDLINE, EMBASE, and Cochrane search was performed for studies addressing antithrombotic therapy prescribed following venous stenting of the iliofemoral tract indicated by acute or chronic thrombotic pathology. A total of 277 articles was identified of which 64 (56 original studies) were selected. Overall, a mean primary patency rate of 82.3% was seen 1 year after the intervention, which decreased to 73.3% after 2 years. In the majority (43 of 56 studies, 77%), treatment was based on use of vitamin K antagonists, either with (18%) or without (59%) use of antiplatelet drugs. Only two studies (4%) directly assessed the effect of antithrombotic therapy on treatment outcomes. The impact of postinterventional antithrombotic therapy on stent patency remains unknown because of limited and insufficient data available in current literature. Further clinical research should more clearly address the role of antithrombotic therapy for preservation of long‐term patency following venous stenting.
Published: 2021

35. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Author: Andrés Cervantes, H.P. Knol, L. Østergaard, M.L. Lydrup, S.A. Radema, R.F. Schmitz, P. Nieboer, J. Hol, I. Edhemovic, K.C.M.J. Peeters, A. Johnsson, F.J.F. Jeurissen, Pieter J. Tanis, A.C.M. van de Luijtgaarden, P. Quarles an Ufford, H. Kim, Hein Putter, W.A. Bleeker, Tone Fokstuen, M E van Leerdam, K. Kovacs, A. Pronk, E.D. Kerver, L.G.H. Dewit, E. Garcia Granero, P.A. Nijenhuis, T. Fokstuen, S. Ottosson, P. Flygare, M.J. Safont, Iris D. Nagtegaal, F. Svendsen Jensen, C. Bratthäll, H.M. Ceha, L. Malmberg, P. Hede, W.M. van der Deure, G. Carlsson, J. Haux, Derk Jan A. de Groot, Esmée A Dijkstra, Renu R. Bahadoer, G.A.P. Nieuwenhuijzen, B. de Valk, B. Lindh, D. Hess, G.L. Beets, J.C. Bernal, A.M.E. Bruynzeel, R.M.P.H. Crolla, C. Kersten, P. Pfeiffer, S. Biondo, M.L. Silviera, Jannet C. Beukema, W.H. Schreurs, O. Hallböök, B.L. Lödén, A. Espí Macías, V. Velenik, L. Österlund, A. Slot, Geke A. P. Hospers, H. de Wilt, A.W.K.S. Marinelli, O. Lundberg, C. Radu, J. die Trill, I. Verbiené, P. Matthiessen, Mathijs P. Hendriks, J.H.M. Bekker, M. Walldén, V. Pachón, H.W. Kapiteijn, J.M. Immink, A. Piwowar, R. Salazar, L. Påhlman, P. Braam, K.E.J. Jensen, S. Festen, O. Mjåland, Elma Meershoek-Klein Kranenbarg, Jaume Capdevila, U. Palenius, K. Villmann, J.J. van der Vliet, Albert J. ten Tije, A. Berglund, Corrie A.M. Marijnen, G. Dafnis, J. Assarsson, J. Capdevila, J.W.T. Dekker, M. Grønlie Guren, G.J. Veldhuis, Q.A.J. Eijsbouts, G.J. Creemers, J.B. Tuynman, C.J.A. Punt, P.H.J.M. Veldman, J. Aparicio, Klaas Havenga, E.D. Geijsen, W.H. Steup, T. Rozema, K. Smedh, Lennart Blomqvist, J. de Boer, Cornelis J.H. van de Velde, S. Jangmalm, J.W.P. Vanstiphout, T.C. Stam, A.C.M. van den Bergh, Annet G H Roodvoets, Janet R. Vos, E.J.M. Siemerink, R.J.I. Bosker, Bengt Glimelius, A. Cervantes, E. Espin, Per Nilsson, A.J. Ten Tije, Ibrahim Edhemovic, Boudewijn van Etten, M. Tascilar, A.N. Nesbakken, G.A. Patijn, O. Reerink, Regina G. H. Beets-Tan, S. Skullman, H. Hörberg, P. Parinkh, G. Svaninger, M.B. Polée, D. Ten Bokkel Huinink, C. Hoff, A.F.T. Olieman, H. van den Berg, F.P. Peters, Torbjörn Holm, J.M. van Rooijen, M.P. Hendriks, J. Benedik, J.H. Svensson, A.L.T. Imholz, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Surgery, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, Radiation Oncology, Internal medicine, VU University medical center, Ophthalmology, Amsterdam Neuroscience - Systems & Network Neuroscience, Oncology, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiotherapy, and Paediatric Oncology
Subjects: 0301 basic medicine, medicine.medical_specialty, Population, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, Folinic acid, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Randomized controlled trial, law, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], medicine, Clinical endpoint, education, education.field_of_study, Performance status, business.industry, Total mesorectal excision, Oxaliplatin, Surgery, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, business, Chemoradiotherapy, medicine.drug
Abstract: BACKGROUND: Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation (RAPIDO) trial aimed to reduce distant metastases without compromising locoregional control. METHODS: In this multicentre, open-label, randomised, controlled, phase 3 trial, participants were recruited from 54 centres in the Netherlands, Sweden, Spain, Slovenia, Denmark, Norway, and the USA. Patients were eligible if they were aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, had a biopsy-proven, newly diagnosed, primary, locally advanced rectal adenocarcinoma, which was classified as high risk on pelvic MRI (with at least one of the following criteria: clinical tumour [cT] stage cT4a or cT4b, extramural vascular invasion, clinical nodal [cN] stage cN2, involved mesorectal fascia, or enlarged lateral lymph nodes), were mentally and physically fit for chemotherapy, and could be assessed for staging within 5 weeks before randomisation. Eligible participants were randomly assigned (1:1), using a management system with a randomly varying block design (each block size randomly chosen to contain two to four allocations), stratified by centre, ECOG performance status, cT stage, and cN stage, to either the experimental or standard of care group. All investigators remained masked for the primary endpoint until a prespecified number of events was reached. Patients allocated to the experimental treatment group received short-course radiotherapy (5?*?5 Gy over a maximum of 8 days) followed by six cycles of CAPOX chemotherapy (capecitabine 1000 mg/m2 orally twice daily on days 1-14, oxaliplatin 130 mg/m2 intravenously on day 1, and a chemotherapy-free interval between days 15-21) or nine cycles of FOLFOX4 (oxaliplatin 85 mg/m2 intravenously on day 1, leucovorin [folinic acid] 200 mg/m2 intravenously on days 1 and 2, followed by bolus fluorouracil 400 mg/m2 intravenously and fluorouracil 600 mg/m2 intravenously for 22 h on days 1 and 2, and a chemotherapy-free interval between days 3-14) followed by total mesorectal excision. Choice of CAPOX or FOLFOX4 was per physician discretion or hospital policy. Patients allocated to the standard of care group received 28 daily fractions of 1·8 Gy up to 50·4 Gy or 25 fractions of 2·0 Gy up to 50·0 Gy (per physician discretion or hospital policy), with concomitant twice-daily oral capecitabine 825 mg/m2 followed by total mesorectal excision and, if stipulated by hospital policy, adjuvant chemotherapy with eight cycles of CAPOX or 12 cycles of FOLFOX4. The primary endpoint was 3-year disease-related treatment failure, defined as the first occurrence of locoregional failure, distant metastasis, new primary colorectal tumour, or treatment-related death, assessed in the intention-to-treat population. Safety was assessed by intention to treat. This study is registered with the EudraCT, 2010-023957-12, and ClinicalTrials.gov, NCT01558921, and is now complete. FINDINGS: Between June 21, 2011, and June 2, 2016, 920 patients were enrolled and randomly assigned to a treatment, of whom 912 were eligible (462 in the experimental group; 450 in the standard of care group). Median follow-up was 4·6 years (IQR 3·5-5·5). At 3 years after randomisation, the cumulative probability of disease-related treatment failure was 23·7% (95% CI 19·8-27·6) in the experimental group versus 30·4% (26·1-34·6) in the standard of care group (hazard ratio 0·75, 95% CI 0·60-0·95; p=0·019). The most common grade 3 or higher adverse event during preoperative therapy in both groups was diarrhoea (81 [18%] of 460 patients in the experimental group and 41 [9%] of 441 in the standard of care group) and neurological toxicity during adjuvant chemotherapy in the standard of care group (16 [9%] of 187 patients). Serious adverse events occurred in 177 (38%) of 460 participants in the experimental group and, in the standard of care group, in 87 (34%) of 254 patients without adjuvant chemotherapy and in 64 (34%) of 187 with adjuvant chemotherapy. Treatment-related deaths occurred in four participants in the experimental group (one cardiac arrest, one pulmonary embolism, two infectious complications) and in four participants in the standard of care group (one pulmonary embolism, one neutropenic sepsis, one aspiration, one suicide due to severe depression). INTERPRETATION: The observed decreased probability of disease-related treatment failure in the experimental group is probably indicative of the increased efficacy of preoperative chemotherapy as opposed to adjuvant chemotherapy in this setting. Therefore, the experimental treatment can be considered as a new standard of care in high-risk locally advanced rectal cancer. FUNDING: Dutch Cancer Foundation, Swedish Cancer Society, Spanish Ministry of Economy and Competitiveness, and Spanish Clinical Research Network.
Published: 2021

36. Bangladesh health journalism: A pilot study exploring the nature and quality of newspaper health reporting

Author: Syed Shariful Islam, Iracema Leroi, A.K.M. Salek, Syed Atiar Rahman Sabuj, Tangila Marzen, Abu Bakar Siddiq, Shahidullah Sikder, Peter M. ten Klooster, Khandakar Mohammad Hossain, Samiha Yunus, Fariha Haseen, Mohammad Tariqul Islam, Moshiur Rahman Khasru, Johannes J. Rasker, TechMed Centre, and Psychology, Health & Technology
Subjects: Medical journalism, business.industry, media_common.quotation_subject, Political science, education, Quality (business), Health literacy, Health reporting, Journalism, Public relations, business, media_common, Newspaper
Abstract: Introduction: The media is an important source of health-related information for patients, general public, policymakers and health professionals and has a large influence on their knowledge and opinions. No studies so far have explored the content, nature and quality of health journalism in Bangladesh. Objectives: To i) explore the nature and quality of media coverage of health stories in Bangladeshi newspapers, ii) understand the perceptions of reporters about medical- and health journalism, including the perceived barriers and facilitators, and iii) identify factors influencing health reporting. Methods: In a mixed-method pilot study, during a five-month period, all medical and healthcare related news articles published in three leading Bangladeshi daily newspapers (N=461), were content analyzed, and journalists were asked in a questionnaire about their knowledge and medical skills. Results: Only 44% of the articles reported in a positive tone on health services aspects, while 27.1% were related to malpractice or treatment errors. Many articles contained questionable medical information (49.9%), mostly regarding unregistered clinicians (67.5%), often referred to as ‘doctor’. Treatment errors by unregistered clinicians were reported seven times more often than those by registered physicians (p
Published: 2021

37. Ferric carboxymaltose in patients with pulmonary arterial hypertension and iron deficiency: a long‐term study

Author: Martin Hellmich, Stephan Rosenkranz, Tilmann Kramer, Kristiana Natsina, Felix Gerhardt, Henrik ten Freyhaus, Daniel Dumitrescu, Thomas Viethen, Max Wissmüller, and Stephan Baldus
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Iron, Diseases of the musculoskeletal system, Ferric Compounds, Gastroenterology, FERRIC CARBOXYMALTOSE, Targeted therapy, Physiology (medical), Internal medicine, medicine, Pulmonary arterial hypertension (PAH), Humans, Orthopedics and Sports Medicine, Maltose, Adverse effect, Aged, Retrospective Studies, Pulmonary Arterial Hypertension, Anemia, Iron-Deficiency, biology, medicine.diagnostic_test, Transferrin saturation, business.industry, Iron deficiency, QM1-695, Original Articles, Iron Deficiencies, Middle Aged, medicine.disease, Ferric carboxymaltose, Ferritin, RC925-935, Human anatomy, biology.protein, Serum iron, Original Article, Female, business, Progressive disease
Abstract: Background Pulmonary arterial hypertension (PAH) is a progressive disease with limited survival. Iron deficiency (ID) correlates with disease severity and mortality. While oral iron supplementation was shown to be insufficient in such patients, the potential impact of parenteral iron on clinical measures warrants further investigation. Methods We retrospectively analysed the long‐term effects of intravenous ferric carboxymaltose (FCM) on iron status and clinical measures in patients with PAH and ID [ferritin
Published: 2021

38. The D*Phase-study

Author: S. Bremer-Hoeve, Marcus J.H. Huibers, H. L. Van, Joost Dekker, M. K. van Dijk, Elise R. Reefhuis, P.M. ten Klooster, M. F. Miggiels, Psychology, Health & Technology, Clinical Psychology, APH - Mental Health, and APH - Personalized Medicine
Subjects: 050103 clinical psychology, Psychotherapist, Non-response, Treatment integrity, RC435-571, Cognitive behavioural therapy, law.invention, Study Protocol, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, SDG 3 - Good Health and Well-being, law, medicine, Humans, 0501 psychology and cognitive sciences, Depression (differential diagnoses), Netherlands, Randomized Controlled Trials as Topic, Protocol (science), Psychiatry, Depressive Disorder, Major, Psychodynamic psychotherapy, Cognitive Behavioral Therapy, business.industry, Depression, 05 social sciences, Cognition, medicine.disease, Psychodynamics, Working alliance, 030227 psychiatry, Psychotherapy, Psychiatry and Mental health, Allegiance, Supportive psychotherapy, Major depressive disorder, business, Prescriptive factors
Abstract: BackgroundSeveral evidence-based psychotherapeutic treatment options are available for depression, but the treatment results could be improved. The D*Phase study directly compares short-term psychodynamic supportive psychotherapy (SPSP) and cognitive behavioural therapy (CBT) for Major Depressive Disorder (MDD). The objectives are 1. to investigate if, from a group level perspective, SPSP is not inferior to CBT in the treatment of major depressive disorder, 2. to build a model that may help predict the optimal type of treatment for a specific individual; and 3. to determine whether a change of therapist or a change of therapist and treatment method are effective strategies to deal with non-response. Furthermore (4.), the effect of the therapeutic alliance, treatment integrity and therapist allegiance on treatment outcome will be investigated.MethodIn this pragmatic randomised controlled trial, 308 patients with a primary diagnosis of MDD are being recruited from a specialised mental health care institution in the Netherlands. In the first phase, patients are randomised 1:1 to either SPSP or CBT. In case of treatment non-response, a second phase follows in which non-responders from treatment phase one are randomised 1:1:1 to one of three groups: continuing the initial treatment with the same therapist, continuing the initial treatment with another therapist or continuing the other type of treatment with another therapist. In both treatment phases, patients are offered sixteen twice-weekly psychotherapy sessions. The primary outcome is an improvement in depressive symptoms. Process variables, working alliance and depressive symptoms, are frequently measured. Comprehensive assessments take place before the start of the first phase (at baseline), in week one, two and four during the treatment, and directly after the treatment (week eight).DiscussionWhile the naturalistic setting of the study involves several challenges, we expect, by focusing on a large and diverse number of research variables, to generate important knowledge that may help enhance the effect of psychotherapeutic treatment for MDD.Trial registrationThe study was registered on 26 August 2016 with the Netherlands Trial Register, part of the Dutch Cochrane Centre (NL5753),https://www.trialregister.nl/trial/5753
Published: 2021

39. Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19

Author: Wouter M. Sluis, Marijke Linschoten, Julie E. Buijs, J. Matthijs Biesbroek, Heleen M. den Hertog, Tessa Ribbers, Dennis J. Nieuwkamp, Reinier C. van Houwelingen, Andreas Dias, Ingeborg W.M. van Uden, Joost P. Kerklaan, H. Paul Bienfait, Sarah E. Vermeer, Sonja W. de Jong, Mariam Ali, Marieke J.H. Wermer, Marieke T. de Graaf, Paul J.A.M. Brouwers, Folkert W. Asselbergs, L. Jaap Kappelle, H. Bart van der Worp, Annemijn M. Algra, Richard C.J.M. Donders, D. Martijn O. Pruissen, Aaf F.M. Kuijper, Clara E.E. van Ofwegen-Hanekamp, Rik S. Hermanides, Hortence E. Haerkens-Arends, Rutger L. Anthonio, Mireille E. Emans, René A. Tio, Jur M. ten Berg, Björn E. Groenemeijer, Ron Pisters, P. Marc van der Zee, Hans-Marc J. Siebelink, Derk O. Verschure, Matthijs F.L. Meijs, Astrid Schut, Robert G. Tieleman, Wanda Hermans-van Ast, Jeroen Schaap, Lucia S. Jewbali, Peter C. Smits, Pim van der Harst, Maarten van Smeden, Wiek H. van Gilst, Cardiovascular Centre (CVC), Neurology, Cardiology, Neurosurgery, and Intensive Care
Subjects: Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Patient discharge, Netherlands/epidemiology, law.invention, Cohort Studies, law, Ischemic Stroke/epidemiology, Risk Factors, Internal medicine, 80 and over, Medicine, Humans, Cumulative incidence, In patient, Hospital Mortality, Stroke, Ischemic Stroke, Netherlands, Aged, COVID-19/epidemiology, Advanced and Specialized Nursing, Aged, 80 and over, business.industry, SARS-CoV-2, Incidence (epidemiology), Incidence, Pulmonary embolism, Clinical course, Age Factors, COVID-19, Middle Aged, medicine.disease, Prognosis, Intensive care unit, Hospitalization, Intensive Care Units, Functional Status, Ischemic stroke, Female, Pulmonary Embolism/epidemiology, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract: Background and Purpose: The frequency of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) varies in the current literature, and risk factors are unknown. We assessed the incidence, risk factors, and outcomes of acute ischemic stroke in hospitalized patients with COVID-19. Methods: We included patients with a laboratory-confirmed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) infection admitted in 16 Dutch hospitals participating in the international CAPACITY-COVID registry between March 1 and August 1, 2020. Patients were screened for the occurrence of acute ischemic stroke. We calculated the cumulative incidence of ischemic stroke and compared risk factors, cardiovascular complications, and in-hospital mortality in patients with and without ischemic stroke. Results: We included 2147 patients with COVID-19, of whom 586 (27.3%) needed treatment at an intensive care unit. Thirty-eight patients (1.8%) had an ischemic stroke. Patients with stroke were older but did not differ in sex or cardiovascular risk factors. Median time between the onset of COVID-19 symptoms and diagnosis of stroke was 2 weeks. The incidence of ischemic stroke was higher among patients who were treated at an intensive care unit (16/586; 2.7% versus nonintensive care unit, 22/1561; 1.4%; P =0.039). Pulmonary embolism was more common in patients with (8/38; 21.1%) than in those without stroke (160/2109; 7.6%; adjusted risk ratio, 2.08 [95% CI, 1.52–2.84]). Twenty-seven patients with ischemic stroke (71.1%) died during admission or were functionally dependent at discharge. Patients with ischemic stroke were at a higher risk of in-hospital mortality (adjusted risk ratio, 1.56 [95% CI, 1.13–2.15]) than patients without stroke. Conclusions: In this multicenter cohort study, the cumulative incidence of acute ischemic stroke in hospitalized patients with COVID-19 was ≈2%, with a higher risk in patients treated at an intensive care unit. The majority of stroke patients had a poor outcome. The association between ischemic stroke and pulmonary embolism warrants further investigation.
Published: 2021

40. Hybrid Energy Resource Allocation for Simultaneous Wireless Information and Power Transfer for Green Communications

Author: Kai-Ten Feng, Li-Hsiang Shen, and Shen Fong Hung
Subjects: Mathematical optimization, Karush–Kuhn–Tucker conditions, Computer Networks and Communications, Renewable Energy, Sustainability and the Environment, business.industry, Computer science, Inductive charging, Resource allocation, Wireless, Maximum power transfer theorem, Resource management, Hybrid power, business, Efficient energy use
Abstract: In this paper, we consider a simultaneous wireless information and hybrid power transfer system for cellular green networks. The small cells (SCs) use hybrid power of on-grid power and green energy harvested from environments, whilst the user equipments (UEs) are enabled by a power-splitting receiver. A quality-of-service (QoS) constrained problem is designed to maximize energy efficiency (EE) considering joint strategies of hybrid power allocation, resource block assignment, and power splitting ratio adjustment. We propose a joint wireless charging and hybrid power based resource allocation (J-WHA) algorithm by transforming the non-concave EE problem into a solvable one based on proved concavity property and Karush-Kuhn-Tucker (KKT) conditions. Moreover, a separated wireless charging and hybrid power based resource allocation (S-WHA) algorithm is proposed to obtain sub-optimal solutions with lower computational complexity. Simulation results demonstrate the convergence of both proposed algorithms in relation to transmission power utilization, wireless charging amount, and system EE. It is shown that the proposed J-WHA and S-WHA algorithms outperform existing schemes in terms of EE performance.
Published: 2021

41. Intelligent Visual Acuity Estimation System With Hand Motion Recognition

Author: Yu Chieh Tien, Chiu Chun Jie, Kai-Ten Feng, and Po-Hsuan Tseng
Subjects: Estimation, Visual acuity, Computer science, business.industry, Vision Tests, Visual Acuity, Hand motion, Hand, Computer Science Applications, Test (assessment), Machine Learning, Human-Computer Interaction, Control and Systems Engineering, medicine, Humans, Computer vision, Artificial intelligence, Electrical and Electronic Engineering, medicine.symptom, business, Algorithms, Software, Information Systems
Abstract: Visual acuity (VA) measurement is utilized to test a subject's acuteness of vision. Conventional VA measurement requires a physician's assistance to ask a subject to speak out or wave a hand in response to the direction of an optotype. To avoid this repetitive testing procedure, different types of automatic VA tests have been developed in recent years by adopting contact-based responses, such as pushing buttons or keyboards on a device. However, contact-based testing is not as intuitive as speaking or waving hands, and it may distract the subjects from concentrating on the VA test. Moreover, problems related to hygiene may arise if all the subjects operate on the same testing device. To overcome these problems, we propose an intelligent VA estimation (iVAE) system for automatic VA measurements that assists the subject to respond in an intuitive, noncontact manner. VA estimation algorithms using maximum likelihood (VAML) are developed to automatically estimate the subject's vision by compromising between a prespecified logistic function and a machine-learning technique. The neural-network model adapts human learning behavior to consider the accuracy of recognizing the optotype as well as the reaction time of the subject. Furthermore, a velocity-based hand motion recognition algorithm is adopted to classify hand motion data, collected by a sensing device, into one of the four optotype directions. Realistic experiments show that the proposed iVAE system outperforms the conventional line-by-line testing method as it is approximately ten times faster in testing trials while achieving a logarithm of the minimum angle of resolution error of less than 0.2. We believe that our proposed system provides a method for accurate and fast noncontact automatic VA testing.
Published: 2021

42. Knowledge, Perceptions, and Attitudes Regarding Antibiotic Use for Lower Respiratory Tract Infections: Insights from Patients in Sri Lanka

Author: Champica K Bodinayake, Robert Rolfe, David T. van Melle, Truls Østbye, Vijitha De Silva, Guus ten Asbroek, Gaya B Wijayaratne, Chathuh Halloluwa, Ajith Nagahawatte, Ruvini Kurukulasooriya, Melissa H Watt, Helen L. Zhang, Yohanna W. Abeysinghe, Gayani Tillekeratne, Christopher W. Woods, Sewwandi Kanchana, Tianchen Sheng, Sky Vanderburg, and Global Health
Subjects: Adult, Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, medicine.drug_class, Antibiotics, Disease, Medical and Health Sciences, Young Adult, Rare Diseases, Antibiotic resistance, Clinical Research, Surveys and Questionnaires, Tropical Medicine, Virology, Lower respiratory tract infection, medicine, Humans, Adverse Drug Reaction Reporting Systems, Medical prescription, Intensive care medicine, Respiratory Tract Infections, Sri Lanka, Practice, Respiratory tract infections, business.industry, Health Knowledge, Public health, Articles, medicine.disease, Anti-Bacterial Agents, Infectious Diseases, Attitudes, Female, Parasitology, Infection, business, Qualitative research
Abstract: Antibiotic resistance is an emerging global public health threat. One of the main drivers of this threat is the inappropriate use of antibiotics. In Sri Lanka, antibiotic consumption is increasing, but little is known locally about how patients perceive antibiotics. We conducted a qualitative study to gain a better understanding of the knowledge, perceptions, and attitudes of patients regarding antibiotics and antibiotic resistance. Semi-structured interviews involving 18 patients with lower respiratory tract infection (LRTI) admitted to a large, public tertiary care hospital in southern Sri Lanka were conducted. Interviews were analyzed to identify themes regarding the patients’ knowledge of LRTI etiology and treatment, perceptions and attitudes toward LRTI treatment, including antibiotics, and patient–physician communication. Most patients mentioned multiple care visits and the use of multiple pharmaceuticals prior to admission. Patients sought a quick resolution to their ailments and frequently visited several private physicians to obtain a satisfying answer. Self-medication was also common. Patients reused prescriptions for antibiotics, kept antibiotics for later use after prematurely stopping their course of treatment, and bought over-the-counter antibiotics. Patients’ knowledge of disease etiology and antibiotics was poor. Only a few patients were aware of antibiotic resistance. Despite the desire to receive more information regarding disease and treatment, patient–provider communication was limited and mainly confined to prescription instructions. This qualitative study performed in Sri Lanka suggests that inappropriate use of antibiotics is a multifactorial problem. To improve antibiotic use, a multifactorial approach that includes educating the public, increasing awareness among physicians, and implementing systems-level changes to restrict access to antibiotics is urgently needed.
Published: 2021

43. Daily symptom associations for urinary urgency and anxiety, depression and stress in women with overactive bladder

Author: Karl J. Kreder, Emma S Greimann, Allen A Mehr, Catherine S. Bradley, Susan K. Lutgendorf, and Patrick Ten Eyck
Subjects: Male, medicine.medical_specialty, Urinary urgency, Visual analogue scale, Urology, Urinary incontinence, Anxiety, Article, Internal medicine, medicine, Humans, Nocturia, Depression (differential diagnoses), Depression, Urinary Bladder, Overactive, business.industry, Obstetrics and Gynecology, Middle Aged, medicine.disease, Urinary Incontinence, Mood, Overactive bladder, Female, medicine.symptom, business
Abstract: Introduction and hypothesis Women with overactive bladder (OAB) report psychological distress, anxiety and depression, but short-term associations between these symptoms are poorly studied. Our objectives were to study daily associations between OAB symptoms and psychological symptoms and test whether these associations were stable when reassessed after 3 months. We hypothesized that OAB symptoms are positively associated with anxiety and depression symptoms over a short-term (daily) basis. Methods Female patients with OAB [bothersome urgency and/or urgency urinary incontinence (UUI)] assessed OAB and mood symptoms at baseline and 3 months using a 3-day bladder diary and visual analog scale (VAS) ratings (0-100 mm) for anxiety, depression and stress. Daily OAB and mood symptom associations were tested using Spearman correlations. Generalized estimating equation (GEE) models tested associations between daily urgency scores and each psychological rating adjusting for covariates, time and a time-symptom interaction term. Results Participants (n = 69) had mean (SD) age 63.3 (13.4) years. Baseline diary outcomes [median (IQR)/day] included day voids 8 (7-11), nocturia 0 (0-1), UUI episodes 1 (0-3) and urgency score 1.75 (1-2.25). Anxiety and depression diagnoses (dx) and treatment (tx) were common (anxiety dx 30.4%, tx 21.7%; depression dx 47.8%, tx 37.7%), but daily anxiety, depression and stress ratings were low [median (IQR) mm 10 (3-35), 5 (1-16), and 16 (4-39), respectively]. Daily urgency scores correlated with anxiety (r = 0.30-0.40, days 1-3, p ≤ 0.01 for all), depression (r = 0.24-0.35, p ≤ 0.05 all) and stress (r = 0.27-0.34, p ≤ 0.03 all). GEE models indicated no significant change in these associations between baseline and 3 months, and OAB treatment did not impact the associations. Conclusions Urgency scores were positively associated with same-day ratings of anxiety, depression and stress in OAB patients.
Published: 2021

44. The need for timely official statistics. The COVID-19 pandemic as a driver for innovation

Author: Piet J. H. Daas, Olav ten Bosch, Bert Kroese, Ben Laevens, Sofie De Broe, Gert Buiten, and Statistics
Subjects: Economics and Econometrics, Economic growth, Official statistics, COVID-19 Pandemic, Coronavirus disease 2019 (COVID-19), new output, National Statistical Institutes, innovation, Management Information Systems, official statistics, Pandemic, Business, Statistics, Probability and Uncertainty, crisis management
Abstract: This paper discusses how Statistics Netherlands managed to respond quickly with a range of new outputs to the sudden increase in the need for statistical information following the outbreak of the COVID-19 pandemic. It describes the innovation process already in place, as well as the innovations in response to the pandemic. This is followed by a discussion of what made speedy innovation and implementation possible, after which lessons are drawn in order to maintain the ability to react quickly to future policy questions. One important success factor is the combination of new data sources with already existing statistics for calibration. The developments at Statistics Netherlands can be seen as a case study. Several other NSIs also accelerated innovation after the outbreak of the pandemic, such as the Australian Bureau of Statistics and the British Office for National Statistics.
Published: 2021

45. Pterygospinous and pterygoalar bars in children

Author: Anıl Özgür, Yüksel Balcı, Kaan Esen, and Barış Ten
Subjects: Ligaments, medicine.diagnostic_test, business.industry, Ossification, Infant, Computed tomography, Pathology and Forensic Medicine, Maximum intensity projection, Sphenoid Bone, Prevalence, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Surgery, Anatomy, medicine.symptom, Child, business, Nuclear medicine, Phylogeny, Retrospective Studies
Abstract: PURPOSE The formation of pterygoalar (Pa) and pterygospinous (Ps) bars are controversial whether they are secondary ossifications with aging or phylogenetic remnant. Therefore we aimed to evaluate the presence of Pa and Ps bars in children on routine cranial computed tomography images. METHODS We retrospectively analyzed the cranial computed tomography images of 500 children under the age of 18. Besides the 0.5 mm axial images, maximum intensity projection and 3D reconstructions were also used. The existence of incomplete or complete Pa and Ps bars were investigated. RESULTS Incomplete and complete Pa bar was detected in 4.6% and 2.2% of the cases, respectively. Incomplete Ps bar was seen in 13.6% of the cases and complete was in 6%. In total, per 1000 sides, 12 (2.4%) complete and 27 (5.4%) incomplete Pa bars were detected. In the same way, 35 (7%) complete and 88 (17.6%) incomplete Ps bars were seen. The smallest age ossification detected was 5 months old. Additionally, the prevalence of Pa and Ps bars between the under and over 10 years old age groups were statistically significant. Aging increased the prevalence. CONCLUSION Considering our results, it seems that the ossification of Pa and Ps ligaments may not be solely related with aging.
Published: 2021

46. Quilting following mastectomy reduces seroma, associated complications and health care consumption without impairing patient comfort

Author: José H. Volders, Johannes H. W. de Wilt, Luc J. A. Strobbe, Ramon R J P van Eekeren, Lotte J van Zeelst, and Britt ten Wolde
Subjects: medicine.medical_specialty, medicine.medical_treatment, Operative Time, Breast Neoplasms, Surgical Flaps, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Postoperative Complications, Ambulatory Care, medicine, Humans, Outpatient clinic, Prospective Studies, Patient Comfort, Mastectomy, Aged, Retrospective Studies, business.industry, Incidence, Incidence (epidemiology), Suture Techniques, Retrospective cohort study, General Medicine, Length of Stay, Middle Aged, medicine.disease, Surgery, Seroma, Treatment Outcome, Oncology, Cohort, Lymph Node Excision, Female, Complication, business, Facilities and Services Utilization, Quilting
Abstract: Contains fulltext : 251554.pdf (Publisher’s version ) (Open Access) BACKGROUND: An important complication following mastectomy is seroma formation. Quilting, in which skin flaps are sutured to the underlying muscle, is reported to reduce seroma incidence, but might induce pain and impair shoulder function. Main objective is to compare quilting with conventional wound closure, regarding seroma incidence, health care consumption, and patient discomfort. METHODS: In a combined prospective and retrospective study, 254 patients undergoing mastectomy and/or axillary lymph node dissection (ALND) were included. Patients received quilting sutures or conventional closure. Primary outcome was clinical significant seroma (CSS). In prospectively included patients shoulder function and analgesic use was observed. RESULTS: CSS incidence was 12.9% in the quilted versus 62.3% in the nonquilted cohort (p
Published: 2021

47. COVID-19-related mortality in kidney transplant and haemodialysis patients

Author: Goffin, Eric, Candellier, Alexandre, Vart, Priya, Noordzij, Marlies, Arnol, Miha, Covic, Adrian, Lentini, Paolo, Malik, Shafi, Reichert, Louis J., Sever, Mehmet S., Watschinger, Bruno, Jager, Kitty J., Gansevoort, Ron T., van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Vogt, Liffert, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Avitum, B. Braun, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Hengst, Maaike, Rydzewski, Andrzej, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G., Zakharova, Elena V., Ambuehl, Patrice Max, Walker, Andrea, Winzeler, Rebecca, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Katicic, Dajana, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Slebe, Jeroen J. P., Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Eiselt, Jaromir, Kielberger, Lukas, el-Wakil, Hala S., Verhoeven, Martine A. M., Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Matceac, Irina, Nistor, Ionut, Cordos, Monica, Groeneveld, J. H. M., Jousma, Jolanda, van Buren, Marjolijn, Elhafeez, Samar Abd, Diekmann, Fritz, Pereira, Tiago Assis, Santos, Augusto Cesar S., Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Hofstra, Julia M., Franco, Antonio, Arroyo, David, Rodríguez-Ferrero, Maria Luisa, Manzanos, Sagrario Balda, Barrios, R. Haridian Sosa, Ávila, Gonçalo, Laranjinha, Ivo, Mateus, Catarina, Lemahieu, Wim, Dirim, Ahmet Burak, Demir, Erol, Å afak, Seda, Turkmen, Aydin, Hollander, Daan A. M. J., Büttner, Stefan, de Vries, Aiko P. J., Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petruliene, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Hemmelder, Marc, Kumar, Mohan N., di Luca, Marina, Tuǧlular, Serhan Z., Kramer, Andrea, Beerenhout, Charles, Luik, Peter T., Kerschbaum, Julia, Tiefenthaler, Martin, Adema, Aaltje Y., Stepanov, Vadim A., Zulkarnaev, Alexey B., Turkmen, Kultigin, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Duivenvoorden, Raphaël, Hilbrands, Luuk, Kerckhoffs, Angele, Maas, Rutger, Lebedeva, Olga, Lopez, Veronica, Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J., Roca, Ana Maria, Nauta, Ferdau, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, Meijers, Björn K. I., Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnelier, Annelies, Wissing, Karl M., de Arriba, Gabriel, Dedinska, Ivana, Pessolano, Giuseppina, Gandolfini, Ilaria, Maggiore, Umberto, Papachristou, Evangelos, Franssen, Casper F. M., Berger, Stefan P., Meijer, Esther, Özyilmaz, Akin, Sanders, Jan Stephan F., Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Ekart, Robert, Abrahams, Alferso C., Molenaar, Femke M., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Tantisattamos, Ekamol, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Sabiu, Gianmarco, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimsevicius, Laurynas, Righetti, Marco, Islam, Mahmud, Braak, Nicole Heitink-Ter, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Internal Medicine, Clinical sciences, Nephrology, ACS - Diabetes & metabolism, AII - Inflammatory diseases, AII - Infectious diseases, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Medical Informatics, ACS - Pulmonary hypertension & thrombosis, APH - Aging & Later Life, APH - Quality of Care, ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, and APH - Global Health
Subjects: medicine.medical_specialty, kidney, Original Article - Dialysis, medicine.medical_treatment, infectious diseases, law.invention, Kidney Failure, SDG 3 - Good Health and Well-being, Renal Dialysis, Risk Factors, law, Internal medicine, medicine, Humans, COVID-19, dialysis, mortality, transplantation, Registries, Renal replacement therapy, Chronic, AcademicSubjects/MED00340, Kidney transplantation, Dialysis, Transplantation, SARS-CoV-2, business.industry, Kidney Transplantation/adverse effects, Hazard ratio, medicine.disease, Kidney Transplantation, Intensive care unit, Comorbidity, Transplant Recipients, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Kidney Failure, Chronic/therapy, Nephrology, Kidney Failure, Chronic, Hemodialysis, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business
Abstract: BACKGROUND AND AIMS: Studies examining kidney failure patients with COVID-19 reported higher mortality in hemodialysis patients than in kidney transplant recipients. However, hemodialysis patients are often older and have more comorbidities. This study investigated the association of type of kidney replacement therapy with COVID-19 severity adjusting for differences in characteristics. METHOD: Data were retrieved from the European Renal Association COVID-19 Database (ERACODA), which includes kidney replacement therapy patients diagnosed with COVID-19 from all over Europe. We included all kidney transplant recipients and hemodialysis patients who presented between February 1st and December 1st 2020 and had complete information reason for COVID-19 screening and vital status at day 28. The diagnosis of COVID-19 was made based on a PCR of a nasal or pharyngeal swab specimens and/or COVID-19 compatible findings on a lung CT scan. The association of kidney transplantation or hemodialysis with 28-day mortality was examined using Cox proportional-hazards regression models adjusted for age, sex, frailty and comorbidities. Additionally, this association was investigated in the subsets of patients that were screened because of symptoms or have had routine screening. RESULTS: A total of 1,670 patients (496 functional kidney transplant recipients and 1,174 hemodialysis patients) were examined. 16.9% of kidney transplant recipients and 23.9% of hemodialysis patients died within 28 days of presentation. In an unadjusted model, the risk of 28-day mortality was 33% lower in kidney transplant recipients compared with hemodialysis patients (hazard ratio (HR): 0.67, 95% CI: 0.52, 0.85). However, in an age, sex and frailty adjusted model, the risk of 28-day mortality was 29% higher in kidney transplant recipients (HR=1.29, 95% CI: 1.00, 1.68), whereas in a fully adjusted model the risk was even 43% higher (HR=1.43, 95% CI: 1.06, 1.93). This association in patients who were screened because of symptoms (n=1,145) was similar (fully adjusted model HR=1.46, 95% CI: 1.05, 2.04). Results were similar when other endpoints were studied (e.g. risk for hospitalization, ICU admission or mortality beyond 28 days) as well as across subgroups. Only age was found to interact significantly, suggesting that the increased mortality risk associated with kidney transplantation was especially present in elderly subjects. CONCLUSION: In this study, kidney transplant recipients had a greater risk of a more severe course of COVID-19 compared with hemodialysis patients when adjusted for age, sex and comorbidities.
Published: 2021

48. Profile of Daughters and Sisters of Women With Polycystic Ovary Syndrome: The Role of Proband’s Glucose Tolerance

Author: Sharon E. Oberfield, Ricardo Azziz, Svetlana Ten, Denis A. Magoffin, Soren Harnois-Leblanc, Ethel Codner, Christianne J. Lane, Jean-Patrice Baillargeon, Michael I. Goran, Maria Isabel Hernandez, Fernando Cassorla, David H Geller, Natasha I. Leibel, and Revi P. Mathew
Subjects: Proband, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Context (language use), Biochemistry, Nuclear Family, Endocrinology, Sex hormone-binding globulin, Risk Factors, Insulin-Secreting Cells, Internal medicine, Glucose Intolerance, medicine, Humans, Insulin, Glucose homeostasis, First-degree relatives, Child, Online Only Articles, Glucose tolerance test, medicine.diagnostic_test, biology, business.industry, Siblings, Ovary, Biochemistry (medical), Glucose Tolerance Test, Polycystic ovary, Cross-Sectional Studies, Glucose, Androgens, biology.protein, Female, Insulin Resistance, business, Body mass index, Polycystic Ovary Syndrome
Abstract: Context First-degree relatives of women with polycystic ovary syndrome (PCOS) present hormonal and metabolic alterations compared to girls unrelated to PCOS. It is unknown whether glucose intolerance in the PCOS proband confers a more severe metabolic predisposition on their first-degree relatives. Objective To determine whether glucose tolerance status in women with PCOS is associated with worsened glucose metabolism and sex hormone levels in their peripubertal daughters or sisters. Design Cross-sectional study. Setting Seven academic centers in North America, South America, and Europe. Patients Sixty-four pairs of women with PCOS and their daughters or younger sisters aged between 8 and 14 years were recruited. Twenty-five mothers or older sisters with PCOS were glucose intolerant (GI) and 39 were normal glucose tolerant (NGT). Main Outcome Measures Beta-cell function estimated by the insulin secretion-sensitivity index-2 (ISSI-2) during an oral glucose tolerance test and by the disposition index during a frequently sampled IV glucose tolerance test. Free testosterone and 17-hydroxyprogesterone (17-OHP) levels. Results Being related to a GI PCOS proband was associated with a lower ISSI-2 (P-value = 0.032) after adjusting for ethnicity, body mass index z-score, and pubertal stage. They also had higher free testosterone (P-value = 0.011) and 17-OHP levels compared to girls with an NGT proband, the latter becoming significant after adjusting for confounders (P-value = 0.040). Conclusions Compared to first-degree female relatives of women with PCOS and NGT, first-degree relatives of women with PCOS and GI display lower beta-cell function and hyperandrogenemia, putting them at higher risk of GI and PCOS development.
Published: 2021

49. CAUSES AND CLINICAL MANIFESTATIONS OF MASQUERADE SYNDROMES IN INTRAOCULAR INFLAMMATORY DISEASES

Author: Susanne M Lubbers, Josianne C. E. M. ten Berge, Johannes R. Vingerling, Alberta A H J Thiadens, Fahriye Groen, Aniki Rothova, and Ophthalmology
Subjects: Adult, Male, medicine.medical_specialty, Retinal Disorder, Adolescent, Fundus Oculi, Disease, Uveitis, chemistry.chemical_compound, Young Adult, medicine, Humans, Fluorescein Angiography, Child, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, Endophthalmitis, medicine.diagnostic_test, business.industry, Eye Neoplasms, Incidence, Infant, Retrospective cohort study, Retinal, General Medicine, Syndrome, Middle Aged, medicine.disease, Fluorescein angiography, Dermatology, Lymphoma, Masquerade syndrome, Vitreous Body, Ophthalmology, chemistry, Child, Preschool, Female, business
Abstract: OBJECTIVE: To identify the clinical characteristics and prevalence of neoplastic and nonneoplastic inflammatory masquerade syndromes (IMSs) in a tertiary center and determine the useful diagnostic tests. METHODS: A retrospective cohort study of consecutive 1906 patients diagnosed with intraocular inflammatory disease. RESULTS: Of all patients initially diagnosed with intraocular inflammatory disease, we identified 116 (6%) patients with noninflammatory causes (neoplastic IMSs in 36/116; 31% and nonneoplastic IMSs in 52/116; 45%). In addition, 26 patients (22%, 1.4% of all) had drug-induced uveitis and 2 (2%, 0.1% of all) had paraneoplastic uveitis. The large B-cell lymphoma was the most common neoplastic IMS (78%), and the major clinical features were presence of cells and floaters in the vitreous (69%) and chorioretinal lesions (33%). The causes of nonneoplastic IMSs included retinal vascular disorders (38%), hereditary retinal diseases (31%), and degenerative ocular disorders (19%). The common clinical manifestations consisted of chorioretinal scars (27%), small white-yellow retinal lesions (17%), and leaking vessels on fluorescein angiography (14%). CONCLUSION: Noninflammatory causes were determined in 6% of a large population with initial diagnosis of intraocular inflammatory disease. Although neoplastic IMS was commonly characterized by vitreous cells and opacities, most common definitive diagnoses in nonneoplastic IMS encompassed diverse retinal disorders.
Published: 2021

50. Metabolic differences between bronchial epithelium from healthy individuals and patients with asthma and the effect of bronchial thermoplasty

Author: Peter J. Sterk, Michel van Weeghel, Tamara Dekker, Abilash Ravi, Annika W.M. Goorsenberg, Jouke T. Annema, Nick H. T. ten Hacken, Frédéric M. Vaz, Annemiek Dijkhuis, Yanaika S. Sabogal Piñeros, Pallav L. Shah, Barbara Dierdorp, René Lutter, and Peter I. Bonta
Subjects: Male, 0301 basic medicine, Severity of Illness Index, Oxidative Phosphorylation, Transcriptome, chemistry.chemical_compound, 0302 clinical medicine, immune system diseases, OXIDATIVE-PHOSPHORYLATION, Immunology and Allergy, health care economics and organizations, COPD, Middle Aged, Healthy Volunteers, Pathophysiology, Female, medicine.symptom, EXPRESSION, Adult, Adolescent, education, Immunology, Bronchial epithelium, Bronchi, Inflammation, Respiratory Mucosa, Young Adult, 03 medical and health sciences, INFLAMMATION, parasitic diseases, medicine, Metabolome, Humans, Aged, Asthma, thermoplasty, Bronchial Thermoplasty, Bronchial thermoplasty, Fatty acid metabolism, business.industry, Gene Expression Profiling, Lipid Metabolism, medicine.disease, DYSFUNCTION, respiratory tract diseases, SEVERITY, 030104 developmental biology, 030228 respiratory system, chemistry, business, metabolism
Abstract: Background: Asthma is a heterogeneous disease with differences in onset, severity, and inflammation. Bronchial epithelial cells (BECs) contribute to asthma pathophysiology.Objective: We determined whether transcriptomes of BECs reflect heterogeneity in inflammation and severity in asthma, and whether this was affected in BECs from patients with severe asthma after their regeneration by bronchial thermoplasty.Methods: RNA sequencing was performed on BECs obtained by bronchoscopy from healthy controls (n = 16), patients with mild asthma (n = 17), patients with moderate asthma (n = 5), and patients with severe asthma (n = 17), as well as on BECs from treated and untreated airways of the latter (also 6 months after bronchial thermoplasty) (n = 23). Lipidome and metabolome analyses were performed on cultured BECs from healthy controls (n = 7); patients with severe asthma (n = 9); and, for comparison, patients with chronic obstructive pulmonary disease (n = 7).Results: Transcriptome analysis of BECs from patients showed a reduced expression of oxidative phosphorylation (OXPHOS) genes, most profoundly in patients with severe asthma but less profoundly and more heterogeneously in patients with mild asthma. Genes related to fatty acid metabolism were significantly upregulated in asthma. Lipidomics revealed enhanced levels of lipid species (phosphatidylcholines, lysophosphatidylcholines. and bis(monoacylglycerol)phosphate), whereas levels of OXPHOS metabolites were reduced in BECs from patients with severe asthma. BECs from patients with mild asthma characterized by hyperresponsive production of mediators implicated in neutrophilic inflammation had decreased expression of OXPHOS genes compared with that in BECs from patients with mild asthma with normoresponsive production. BECs obtained after thermoplasty had significantly increased expression of OXPHOS genes and decreased expression of fatty acid metabolism genes compared with BECs obtained from untreated airways.Conclusion: BECs in patients with asthma are metabolically different from those in healthy individuals. These differences are linked with inflammation and asthma severity, and they can be reversed by bronchial thermoplasty.
Published: 2021

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