44 results on '"Takuya Kitamura"'
Search Results
2. Cervicothoracic spinal alignment and neck flexor muscle endurance in young and older adult females with and without neck and shoulder pain (Katakori in Japanese)
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Masaru Kanda, Takuya Kitamura, and Naritoshi Sato
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Cervicothoracic spinal alignment and neck flexor muscle endurance ,medicine.medical_specialty ,Physical medicine and rehabilitation ,Young and elderly females ,business.industry ,Medicine ,Original Article ,Physical Therapy, Sports Therapy and Rehabilitation ,Flexor muscles ,Young adult ,business ,Neck and shoulder pain (NSP) - Abstract
[Purpose] The characteristics of neck and shoulder pain (NSP) in different age populations have not been sufficiently examined. Therefore, the purpose of this study was to compare and verify the cervicothoracic spinal alignment and neck flexor muscle endurance of young and older adult females with and without NSP. [Participants and Methods] We assessed 72 female participants (39 young participants, 33 elderly participants, 43 NSP, 29 non-NSP) aged 18-82 years who were recruited for this study. Cervicothoracic spinal alignment measurements were obtained with forward head alignment (FHA) along with the upper thoracic angle. The neck flexor endurance test was performed. [Results] There were no significant age-by-group interactions for any of the assessment variables. However, the upper thoracic angle and neck flexor muscle endurance showed significant effects in the groups. Age also had significant effects on FHA and upper thoracic angle. [Conclusion] These results suggested that the neck flexor muscle endurance was more appropriate as an evaluation tool for older adult females with NSP. It was also suggested that the cervical flexor muscle endurance and upper thoracic angle were more appropriate as evaluation tools for young adult females with NSP.
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- 2021
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3. A Novel Exercise Facilitation Method in Combination with Cognitive Behavioral Therapy Using the Ikiiki Rehabilitation Notebook for Intractable Chronic Pain: Technical Report and 22 Cases
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Ryo Yamazaki, Takanori Murakami, Shouhei Yamada, Naofumi Otsuru, Takuya Kitamura, Kei Watanabe, Kozo Anno, Yasuyuki Mizuno, Hajime Ijiro, Shinji Kimura, Makoto Nishihara, Madoka Iwasaki, Masako Hosoi, and Takako Matsubara
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medicine.medical_specialty ,Activities of daily living ,Leadership and Management ,medicine.medical_treatment ,Health Informatics ,notebook ,Health Information Management ,Quality of life ,Rating scale ,Technical Note ,Medicine ,education ,Rehabilitation ,catastrophizing thoughts ,business.industry ,Health Policy ,Chronic pain ,medicine.disease ,Cognitive behavioral therapy ,quality of life ,psychological therapy ,Presenteeism ,Physical therapy ,Pain catastrophizing ,business - Abstract
Recent clinical practice guidelines for chronic pain indicate, with a high evidence level, that the combination of exercise and cognitive behavioral therapy (CBT) is effective. The purpose of this study was to evaluate the effectiveness of an exercise facilitation method in combination with CBT using the “Ikiiki Rehabilitation Notebook” for patients with intractable chronic pain. “Ikiiki” means active in Japanese. A total of 22 cases with chronic low back (n = 13), lower extremity (n = 8), or neck (n = 1) pain were treated using this notebook. Two cases dropped out, leaving 22 cases. Each case was evaluated in terms of the numerical rating scale (NRS) of the pain, activities of daily living (ADL), pain catastrophizing scale (PCS), and quality of life (QOL) at pretreatment and post-treatment. The endpoint of the method was to achieve the long-term goals set by the patients. The mean treatment period was 11.2 months. The outcomes were as follows: improvement of presenteeism: nine cases; enhanced participation in hobbies: seven cases; improved school attendance: two cases; return to work: one case; improvement of self-care and/or self-efficacy: three cases. The NRS, ADL, PCS, and QOL were significantly improved after the treatment. This method is possibly valuable for educating patients about the cause and treatment of chronic pain and actively facilitating exercise and social participation. Further studies are needed to investigate the effectiveness of using this notebook for the patient with intractable chronic pain.
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- 2021
4. Three Cases in which Kampo Therapy was Effective in the Long Term for Menstrual Symptoms in Patients with Mental Illness
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Takuya Kitamura, Junko Ebi, Tomoko Suzuki, Keiichi Anzai, Yuko Nakano, Hiromi Komiya, and Tadamichi Mitsuma
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Pediatrics ,medicine.medical_specialty ,business.industry ,Kampo ,Medicine ,In patient ,Menstrual symptoms ,business ,Mental illness ,medicine.disease ,Term (time) - Published
- 2020
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5. Ultrasonography Comparison of Muscle Thickness and Echo Intensity of the Trunk Muscles and Psoas Major in Healthy Young and Elderly Females
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Masaru Kanda, Naritoshi Sato, Takuya Kitamura, and Shoya Wakana
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business.industry ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,business - Published
- 2020
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6. Factors Affecting Prolonged Neck and Shoulder Pain (Katakori) in Female Adolescents: Focus on Maximal Voluntary Contraction and Endurance of Neck Flexor and Extensor Muscles and Neck Disability Index (NDI)
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Takuya Kitamura, Yusuke Suzuki, Masayoshi Kubo, Isamu Konishi, Masaru Kanda, Kei Watanabe, and Naritoshi Sato
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business.industry ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,business - Published
- 2020
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7. Neural symptoms in a gene knockout mouse model of Sjögren‐Larsson syndrome are associated with a decrease in 2‐hydroxygalactosylceramide
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Takuya Kitamura, Akio Kihara, Takayuki Sassa, Tsukasa Kanetake, Koki Nojiri, Megumi Sawai, Satoko Hattori, and Tsuyoshi Miyakawa
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0301 basic medicine ,medicine.medical_specialty ,Light ,Galactosylceramides ,Anxiety ,Motor Activity ,Biochemistry ,Mice ,03 medical and health sciences ,Myelin ,0302 clinical medicine ,Internal medicine ,Genetics ,medicine ,Animals ,Humans ,Molecular Biology ,Gene ,Mice, Knockout ,Sjögren–Larsson syndrome ,Behavior, Animal ,integumentary system ,Depression ,business.industry ,food and beverages ,Lipid Metabolism ,medicine.disease ,Aldehyde Oxidoreductases ,Sphingolipid ,Mice, Inbred C57BL ,Sjogren-Larsson Syndrome ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,nervous system ,Knockout mouse ,sense organs ,business ,030217 neurology & neurosurgery ,Biotechnology - Abstract
Insulation by myelin lipids is essential to fast action potential conductivity: changes in their quality or amount can cause several neurologic disorders. Sjögren-Larsson syndrome (SLS) is one such disorder, which is caused by mutations in the fatty aldehyde dehydrogenase ALDH3A2. To date, the molecular mechanism underlying SLS pathology has remained unknown. In this study, we found that Aldh3a2 is expressed in oligodendrocytes and neurons in the mouse brain, and neurons of Aldh3a2 knockout (KO) mice exhibited impaired metabolism of the long-chain base, a component of sphingolipids. Aldh3a2 KO mice showed several abnormalities corresponding to SLS symptoms in behavioral tests, including increased paw slips on a balance beam and light-induced anxiety. In their brain tissue, 2-hydroxygalactosylceramide, an important lipid for myelin function and maintenance, was reduced by the inactivation of fatty acid 2-hydroxylase. Our findings provide important new insights into the molecular mechanisms responsible for neural pathogenesis caused by lipid metabolism abnormalities.-Kanetake, T., Sassa, T., Nojiri, K., Sawai, M., Hattori, S., Miyakawa, T., Kitamura, T., Kihara, A. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
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- 2018
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8. Local Elasto-plasticity Behavior of HT780 Butt Welded Joint Analyzed by Digital Image Correlation Technique
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Riccardo Fincato, Seiichiro Tsutsumi, and Takuya Kitamura
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010302 applied physics ,Digital image correlation ,Materials science ,business.industry ,Mechanical Engineering ,Metals and Alloys ,Elasto plasticity ,02 engineering and technology ,Welding ,Structural engineering ,Plasticity ,01 natural sciences ,020501 mining & metallurgy ,Surfaces, Coatings and Films ,law.invention ,0205 materials engineering ,Mechanics of Materials ,law ,0103 physical sciences ,Fracture (geology) ,business ,Joint (geology) - Published
- 2017
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9. Classification of impulse breakdown mechanisms under non-uniform electric field in air
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Hiroki Kojima, Takuya Kitamura, Kinya Kobayashi, Toshiaki Rokunohe, Naoki Hayakawa, Atsushi Otake, Tatsuro Kato, Katsuki Hotta, and Hitoshi Okubo
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010302 applied physics ,Imagination ,Speed measurement ,Materials science ,business.industry ,media_common.quotation_subject ,Electrical engineering ,Mechanics ,Impulse (physics) ,01 natural sciences ,Cathode ,010305 fluids & plasmas ,law.invention ,Anode ,law ,Electric field ,0103 physical sciences ,Breakdown voltage ,Electrical and Electronic Engineering ,business ,media_common - Abstract
To clarify the breakdown mechanism and the conditions leading to the breakdown under non-uniform electric field in air, we studied the details of breakdown characteristics and mechanism in air by using an ultra-high speed measurement system. We clarified that there were two types of breakdown mechanism in air. The one is the channel heating breakdown, and the other is the leader-type channel development breakdown. These breakdown mechanisms are dominated by three conditions: arrival of secondary streamer from high-voltage anode to opposite grounded cathode, channel heating, and leader-type channel initiation. We studied these conditions quantitatively, and revealed the conditions leading to the breakdown, and the breakdown mechanisms in air were classified. Finally, we clarified the factors, e.g. critical instantaneous power for the secondary streamer arrival, dominating these conditions based on the breakdown mechanism under non-uniform electric field in air.
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- 2016
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10. Effects of a Physical Therapy Intervention for Degenerative Lumbar Kyphosis: A Case Report
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Naritoshi Sato, Takuya Kitamura, Ryota Gozu, Shyoya Hoshi, and Kei Watanabe
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Physical medicine and rehabilitation ,business.industry ,Intervention (counseling) ,Physical therapy ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,030212 general & internal medicine ,Lumbar kyphosis ,business ,030217 neurology & neurosurgery - Published
- 2016
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11. Reduction of Impulsive Noise in OFDM Transmission by Subtracting the Generated Replica Signal
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Akira Nakamura, Kohei Ohno, Takuya Kitamura, and Makoto Itami
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Reduction (complexity) ,Computer science ,Noise (signal processing) ,business.industry ,Replica ,Acoustics ,Media Technology ,Electrical and Electronic Engineering ,Telecommunications ,business ,Signal ,Ofdm transmission ,Computer Science Applications - Published
- 2015
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12. Difference in Task Difficulty Level Based on Task Order of Structuring Task of Logic Structure and Segmentation Task
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Takuya Kitamura and Tsukasa Hirashima
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Artificial Intelligence ,business.industry ,Computer science ,Order (business) ,Segmentation ,Artificial intelligence ,Logic structure ,business ,Structuring ,Software ,Task (project management) - Published
- 2019
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13. Fast Sparse Least Squares Support Vector Machines by Block Addition
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Fumito Ebuchi and Takuya Kitamura
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Basis (linear algebra) ,Computer science ,business.industry ,Feature vector ,020206 networking & telecommunications ,Pattern recognition ,Feature selection ,02 engineering and technology ,Sparse approximation ,Linear discriminant analysis ,Least squares ,Support vector machine ,Kernel (linear algebra) ,Least squares support vector machine ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,Cholesky decomposition - Abstract
In this paper, we propose two fast feature selection methods for sparse least squares support vector training in reduced empirical feature space. In the first method, we select the training vectors as the basis vectors of the empirical feature space from the standpoint of the similarity. The complexity of the selection can be lower than that of the conventional method because we use the inner product values of training vectors without linear discriminant analysis or Cholesky factorization which are used by the conventional methods. In the second method, the selection method is forward selection by block addition which is a wrapper method. This method can decrease the size of the kernel matrix in the optimization problem. The selecting time can be shorter than that of the conventional methods because the computational complexity of the selecting basis vectors depends on the size of the kernel matrix. Using benchmark datasets, we show the effectiveness of the proposed methods.
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- 2017
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14. Combination therapy with an angiotensin-converting-enzyme inhibitor and an angiotensin II receptor antagonist ameliorates microinflammation and oxidative stress in patients with diabetic nephropathy
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Daisuke Ogawa, Kenichi Shikata, Hirofumi Makino, Takuya Kitamura, Tatsuaki Nakatou, Nobuo Kajitani, and Akihiko Nakamura
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Angiotensin receptor ,biology ,Combination therapy ,business.industry ,Endocrinology, Diabetes and Metabolism ,Angiotensin-converting enzyme ,Angiotensin II receptor antagonist ,Articles ,Diabetic nephropathy ,General Medicine ,Renin–angiotensin system ,Pharmacology ,medicine.disease ,Nephropathy ,Clinical Science and Care ,Losartan ,Imidapril ,Combination ,Internal Medicine ,medicine ,biology.protein ,Original Article ,business ,medicine.drug - Abstract
Aims/Introduction Recent studies have pointed to the effectiveness of combination therapy with an angiotensin-converting-enzyme inhibitor (ACEI) and an angiotensin receptor blocker (ARB) for diabetic nephropathy. However, some controversy over this combination treatment remains and the mechanisms underlying its renoprotective effects have not been fully clarified. Therefore, we compared the renoprotective effects of imidapril (ACEI) and losartan (ARB) combination therapy with losartan monotherapy in patients with diabetic nephropathy. We also compared the anti-inflammatory and anti-oxidative stress effects of these two treatments. Materials and Methods A total of 32 Japanese patients with type 2 diabetes and nephropathy were enrolled. Patients were randomized to either 100 mg/day losartan (n = 16) or 50 mg/day losartan plus 5 mg/day imidapril (n = 16). We evaluated clinical parameters, serum concentrations of high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-18 (IL-18) and monocyte chemotactic protein-1 (MCP-1), and the urinary concentrations of IL-18, MCP-1 and 8-hydroxy-2′-deoxyguanosine (8-OHdG) at 24 and 48 weeks after starting treatment. Results Blood pressure was not significantly different between the two groups. The serum levels of hs-CRP, sICAM-1 and IL-18, as well as urinary excretion of albumin, IL-18 and 8-OHdG decreased significantly in the combination therapy group at 48 weeks. The percent decreases in serum IL-18 concentrations and urinary IL-18 and 8-OHdG were significantly greater in the combination therapy group than in the monotherapy group. Conclusions Combination therapy with an ACEI and an ARB could be beneficial for treating diabetic nephropathy through its anti-inflammatory and anti-oxidative stress effects.
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- 2012
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15. Percutaneous transluminal angioplasty in the treatment of bilateral brachiocephalic vein stenosis in hemodialysis patient
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Terumi Higuchi, Maki Kitai, Satoshi Saito, Hiroaki Ueda, Takuya Kitamura, Erina Okawa, Akito Shimura, Shinichi Enomoto, Harumi Setoguchi, Hideyuki Ando, Mari Mizuno, Toshio Yamazaki, Masaaki Chiku, Emiko Ishida, Tomoya Takasaki, and Yoko Nakashima
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Stenosis ,medicine.medical_specialty ,Percutaneous ,business.industry ,medicine.medical_treatment ,medicine ,Hemodialysis ,medicine.disease ,Transluminal Angioplasty ,business ,Brachiocephalic vein ,Surgery - Published
- 2011
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16. Subspace based least squares support vector machines for pattern classification
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Takuya Kitamura, Shigeo Abe, and Kazuhiro Fukui
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Support vector machine ,Kernel (linear algebra) ,Similarity (network science) ,business.industry ,Margin (machine learning) ,Pattern recognition ,Artificial intelligence ,Similarity measure ,business ,Least squares ,Subspace topology ,Mathematics ,Slack variable - Abstract
In this paper, we discuss subspace based least squares support vector machines (SSLS-SVMs), in which an input vector is classified into the class with the maximum similarity. Namely, we define the similarity measure for each class by the weighted sum of vectors called dictionaries and optimize the weights so that the margin between classes is optimized. Because the similarity measure is defined for each class, the similarity measure associated with a data sample needs to be the largest among all the similarity measures. Introducing slack variables we define these constraints by equality constraints. Then the proposed SSLS-SVMs is similar to LS-SVMs by all-at-once formulation. Because all-at-once formulation is inefficient, we also propose SSLS-SVMs by one-against-all formulation. We demonstrate the effectiveness of the proposed methods with the conventional method for two-class problems.
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- 2009
17. Subspace based linear programming support vector machines
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Kazuhiro Fukui, Syogo Takeuchi, Shigeo Abe, and Takuya Kitamura
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Support vector machine ,Kernel (linear algebra) ,Similarity (network science) ,Hyperplane ,business.industry ,Pattern recognition ,Artificial intelligence ,Similarity measure ,business ,Linear subspace ,Subspace topology ,Kernel principal component analysis ,Mathematics - Abstract
In subspace methods, the subspace associated with a class is represented by a small number of vectors called dictionaries and using the dictionaries the similarity measure is defined and an input is classified into the class with the highest similarity. Usually, each dictionary is given an equal weight. But if subspaces of different classes overlap, the similarity measures for the overlapping regions will not give useful information for classification. In this paper, we propose optimizing the weights for the dictionaries using the idea of support vector machines (SVMs). Namely, first we map the input space into the empirical feature space, perform kernel principal component analysis (KPCA) for each class, and define a similarity measure. Then considering that the similarity measure corresponds to the hyperplane, we formulate the optimization problem as maximizing the margin between the class associated with the dictionaries and the remaining classes. The optimization problem results in all-at-once formulation of linear SVMs. We demonstrate the effectiveness of the proposed method with that of the conventional methods for two-class problems.
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- 2009
18. The clinical oro-facial findings of an 11-year-old Japanese boy with 47, XYY: A case report
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Sachiko Hayashi-Sakai, Makoto Sakamoto, Jun Sakai, Yo Taguchi, and Takuya Kitamura
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Orthodontics ,Molar ,Cephalometric analysis ,Dental arch ,Tooth size ,business.industry ,Bimaxillary protrusion ,medicine.medical_treatment ,Mandible ,Dentistry ,Crown (dentistry) ,stomatognathic diseases ,Dental mineralization degress ,medicine.anatomical_structure ,stomatognathic system ,Pediatrics, Perinatology and Child Health ,Medicine ,Dentistry (miscellaneous) ,47, XYY males ,Dentin mineralization ,business ,Permanent teeth - Abstract
47, XYY is a sex chromosome-number disorder occurring in males. Pediatric dentists seldom report encountering 47, XYY males, probably because there are no overt signs of the disease. The purpose of this report is to present the clinical oro-facial findings of the case of a 47, XYY boy based on cephalometric analysis and study model examinations as well as micro-CT measurement of tooth mineralization. An 11-year-old Japanese boy was referred to our clinic for extraction of primary teeth because of their prolonged retention. He had 47, XYY disorder, pulmonary hypertension, and slight mental retardation. Cephalometric analysis and study model examinations that included a comparison of tooth size and arch assessments were performed. A further attempt was made to demonstrate the degree of dentin mineralization in primary molars. The boy's height and weight were normal but his head circumference had exceeded the 94th percentile since 2 years of age. The cephalometric analysis showed an increase in the lower facial height and bimaxillary protrusion with a longer mandible. Study model examination revealed that the mesio-distal crown widths of all erupted primary and permanent teeth were larger than the standard values, except for the mandibular permanent canines. The degree of dentin mineralization was almost normal in the crown and root areas. A profilogram showed an increase in the lower facial height and bimaxillary protrusion with a longer mandible. The dental arch showed a remarkably contracted width but an extended length. The crown width was larger than the standard values, but the distribution of the degree of dentin mineralization differed little from normal.
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- 2008
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19. Sparse Extreme Learning Machine Classifier Using Empirical Feature Mapping
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Takuya Kitamura
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0209 industrial biotechnology ,Computer science ,Computer Science::Neural and Evolutionary Computation ,Stability (learning theory) ,02 engineering and technology ,Machine learning ,computer.software_genre ,020901 industrial engineering & automation ,Margin (machine learning) ,0202 electrical engineering, electronic engineering, information engineering ,Extreme learning machine ,Learning classifier system ,Quantitative Biology::Neurons and Cognition ,business.industry ,Pattern recognition ,Quadratic classifier ,Support vector machine ,ComputingMethodologies_PATTERNRECOGNITION ,Margin classifier ,Feedforward neural network ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,computer ,Classifier (UML) ,Feature learning - Abstract
Usually, the solution of the conventional extreme learning machine, which is a type of single-hidden-layer feedforward neural networks, is not sparse.
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- 2016
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20. [Untitled]
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Takuya Kitamura and Takashi Nagao
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Computer science ,business.industry ,General Medicine ,Structural engineering ,business ,Reliability based design ,Bulkhead (partition) - Published
- 2005
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21. [Untitled]
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Kobayashi Yoichi, Nishiyama Takahiro, Tomohiro Bessho, Takuya Kitamura, Imai Makoto, and Kazuhiro Yamamura
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Permeability (earth sciences) ,Engineering ,business.industry ,Breakwater ,Geotechnical engineering ,General Medicine ,Structural engineering ,business - Published
- 2005
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22. [Untitled]
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Kazuhiro Yamamura, Mitsuru Takahashi, Takuya Kitamura, Kenji Kurio, Tomohiro Bessho, and Yoshio Mitarai
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Engineering ,Waste management ,business.industry ,Head (vessel) ,Joint (building) ,General Medicine ,business ,Civil engineering ,Waste disposal - Published
- 2004
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23. [Untitled]
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Takashi Nagao and Takuya Kitamura
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Optimal design ,Engineering ,business.industry ,General Medicine ,Structural engineering ,business ,Decision model ,Civil engineering ,Bulkhead (partition) - Published
- 2004
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24. Sparse LS-SVM in the Sorted Empirical Feature Space for Pattern Classification
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Takuya Kitamura and Kohei Asano
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Support vector machine ,Training set ,business.industry ,Feature vector ,Least squares support vector machine ,sort ,Pattern recognition ,Artificial intelligence ,Linear independence ,business ,Least squares ,Mathematics - Abstract
In this paper, we discuss an improved sparse least support vector training in the reduced empirical feature space which is generated by linearly independent training data. In this method, we select the linearly independent training data as the basis vectors of empirical feature space. Then, before we select these data, we sort training data in ascending order from the standpoint of classification with the values of objective function in training least squares support vector machines. Thus, good training data from the standpoint of classification can be selected in preference as the basis vectors of the empirical feature space. Next, we train least squares support vector machine in the empirical feature space. Then, the solution is sparse since the number of support vectors is equal to that of the basis vectors. Using two-class problems, we evaluate the effectiveness of the proposed method over the conventional methods.
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- 2015
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25. Influence of space charge by primary and secondary streamers on breakdown mechanism under non-uniform electric field in air
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Takuya Kitamura, Tatsuro Kato, Kinya Kobayashi, Naoki Hayakawa, Toshiaki Rokunohe, and Hiroki Kojima
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Primary (chemistry) ,Materials science ,business.industry ,Electric field ,Electrical breakdown ,Optoelectronics ,Charge carrier ,business ,Space charge ,Mechanism (sociology) ,Electric discharge in gases - Published
- 2014
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26. STUDIES ON STABILITY AND DURABILITY OF A NET FOR A CAISSON FOUNDATION
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Imai Makoto, Takao Sato, and Takuya Kitamura
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Engineering ,Wharf ,Work (electrical) ,business.industry ,Breakwater ,Foundation (engineering) ,Caisson ,General Medicine ,business ,Civil engineering ,Port (computer networking) ,Durability ,Chain (unit) - Abstract
In long-time extennsion works of a breakwater and a wharf facing the open sea, there have been many cases where some ends and corners of the base of structure are damage befor to next work starts.This was also the case with the extension work of the East Breakwater of Hitachi-Naka Port that faces the Pacific Ocean in a severe construction. Under such circumstances, a study meeting was estalished in 1994 by the Kashima Harbor Construction Office, No.2 Harbor Construction Bureau of the Construction Ministry. The meeting is composed of learned men of experience and businessmen concerned with the port and harbor works to study and discuss some stuructures that may replace the concrete aporon block. As a result, “protective equipment of steel frame with chain net (hereinafter called a net for foundation)”, which is lighter and larger in convering area than the concrete apron block, etc, was devised and used for the actual construction.This paper descrdes the construction status, results of followup investion and those of hydraulic model experiments of the net for a foundation at East Breakwater of Hitachi-Naka Port.
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- 1999
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27. Development of a Learning Environment for Logic- Structure-Assembling Exercises and Its Experimental Evaluation
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Kazushige Maeda, Tsukasa Hirashima, Takuya Kitamura, Hironari Hase, and Yusuke Hayashi
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Development (topology) ,Artificial Intelligence ,business.industry ,Computer science ,Learning environment ,Logic structure ,Software engineering ,business ,Software - Published
- 2017
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28. Improved Multi-class Support Vector Machines Using Novel Methods of Model Selection and Feature Extraction
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Takuya Kitamura and Kengo Ota
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Support vector machine ,Kernel (linear algebra) ,Margin (machine learning) ,business.industry ,Generalization ,Model selection ,Feature extraction ,Pattern recognition ,Artificial intelligence ,business ,Class (biology) ,Subspace topology ,Mathematics - Abstract
In this paper, to improve the generalization capability of multi-class SVMs, we propose 1 a novel model selection and 2 feature extraction by SVMs. In 1, unlike the conventional model selection in multi-class SVMs, we determine hyper-parameters, which are kernel parameter and margin parameter, for each separating hyper-plane, separately. Namely, for each separating hyper-plane, we estimate the generalization capability and select optimal values of the hyper-parameters, separately. In 2, we define the weighted vectors of decision functions determined by training multi-class SVMs as the basis vector of the subspace, and we determine the separating hyper-planes in the subspace. Thus, we can determine the new separating hyper-planes during considering the all separating hyper-planes. Using multi-class benchmark data sets, we evaluate the effectiveness of the proposed methods over the conventional method.
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- 2013
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29. A Novel Method of Sparse Least Squares Support Vector Machines in Class Empirical Feature Space
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Takuya Kitamura and Takamasa Sekine
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Training set ,business.industry ,Feature vector ,Pattern recognition ,Machine learning ,computer.software_genre ,Least squares ,Class (biology) ,Support vector machine ,Least squares support vector machine ,Decision boundary ,Artificial intelligence ,Benchmark data ,business ,computer ,Mathematics - Abstract
In this paper, we propose a novel method of sparse least squares support vector machine (SLS-SVM) that is trained in each class empirical feature space spanned by the independent training data belonging to the associated class. And we determine the decision function in each class empirical feature space. To prevent that the information of other classes is lost because of generating each class empirical feature space separately, we combine the decision functions of all the classes by training LS-SVM in primal form. Using benchmark data sets, we evaluate the effectiveness of the proposed method over the conventional methods.
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- 2012
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30. Improving of performance of OFDM reception under Class-A impulsive channel by replica signal estimation of impulse
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Takuya Kitamura, Makoto Itami, and Kohei Ohno
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Engineering ,Orthogonal frequency-division multiplexing ,business.industry ,Replica ,Data_CODINGANDINFORMATIONTHEORY ,Impulse (physics) ,Impulse noise ,Channel models ,symbols.namesake ,Gaussian noise ,Electronic engineering ,symbols ,business ,Ofdm transmission ,Computer Science::Information Theory ,Communication channel - Abstract
One of the major factors of performance degradation in OFDM transmission is influence of additive impulsive noise. the proposed scheme using replica signal estimation could improve performance under the impulsive channels. In this paper, the performance of the proposed scheme is evaluated under the realistic channel to enhance usefulness of this scheme. Middleton Class A noise model is used as the realistic channel model. As the result of computer simulation, it was confirmed that the proposed scheme is effective under the Class A noise channel model.
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- 2012
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31. Multiple Nonlinear Subspace Methods Using Subspace-based Support Vector Machines
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Shigeo Abe, Takuya Kitamura, and Yusuke Tanaka
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Training set ,business.industry ,Computer science ,Pattern recognition ,Linear subspace ,Projection (linear algebra) ,Support vector machine ,Random subspace method ,Kernel (linear algebra) ,ComputingMethodologies_PATTERNRECOGNITION ,Kernel method ,Discriminant function analysis ,Margin (machine learning) ,Artificial intelligence ,business ,Subspace topology - Abstract
In this paper, we propose multiple nonlinear subspace methods (MNSMs), in which each class consists of several subspaces with different kernel parameters. For each class and each candidate kernel parameter, we generate the subspace by KPCA, and obtain the projection length of an input vector onto each subspace. Then, for each class, we define the discriminant function by the sum of the weighted lengths. These weights in the discriminant function are optimized by subspace-based support vector machines (SS-SVMs) so that the margin between classes is maximized while minimizing the classification error. Thus, we can weight the subspaces for each class from the standpoint of class separability. Then, the computational cost of the model selection of MNSMs is lower than that of SS-SVMs because for SS-SVMs two hyper-parameters, which are the kernel parameter and the margin parameter, must be chosen before training. We show the advantages of the proposed method by computer experiments with benchmark data sets.
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- 2011
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32. Feature Extraction Using Support Vector Machines
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Yasuyuki Tajiri, Ryosuke Yabuwaki, Shigeo Abe, and Takuya Kitamura
- Subjects
Relevance vector machine ,Kernel method ,business.industry ,Feature vector ,Margin classifier ,Least squares support vector machine ,Decision boundary ,Pattern recognition ,Vector projection ,Artificial intelligence ,business ,Projection (linear algebra) ,Mathematics - Abstract
We discuss feature extraction by support vector machines (SVMs). Because the coefficient vector of the hyperplane is orthogonal to the hyperplane, the vector works as a projection vector. To obtain more projection vectors that are orthogonal to the already obtained projection vectors, we train the SVM in the complementary space of the space spanned by the already obtained projection vectors. This is done by modifying the kernel function. We demonstrate the validity of this method using two-class benchmark data sets.
- Published
- 2010
- Full Text
- View/download PDF
33. A moving control of a robotic walker for standing, walking and seating assistance
- Author
-
Kunikatsu Takase, Daisuke Chugo, Takuya Kitamura, Tai Asawa, and Songmin Jia
- Subjects
Engineering ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Control (management) ,Mobile robot ,Motion control ,Medical services ,Brushless motors ,Physical medicine and rehabilitation ,Medical robotics ,medicine ,Elderly people ,business ,Function (engineering) ,Simulation ,media_common - Abstract
This paper proposes a robotic walker system with standing, walking and seating assistance function. Our system focuses on domestic use for aged person who needs nursing in their daily life. Our key ideas are two topics. The first topic is combination of standing assistance function and walking assistance function. In previous works, many assistance devices are specialized in only “standing-up operation” or “walking operation”. However, in their daily life, elderly people need standing, walking and seating assistance continuously by the same device. Therefore, our developing assistance system can support both operations by a small sized mechanism which is easy to use in the home. The second topic is a seating position adjustment assistance. From questionnaires of nursing specialists, a seating position adjustment requires the elderly people to walk backward and it is difficult operation for them. Furthermore, in many cases, a failure of this operation causes a fracture which has high risk to fall into bedridden life. Thus, our developing system can assist the aged users to adjust the seating position safety. The performance of our proposed system is verified by experiments using our prototype.
- Published
- 2009
- Full Text
- View/download PDF
34. A rehabilitation walker with standing and walking assistance
- Author
-
Tai Asawa, Songmin Jia, Kunikatsu Takase, Takuya Kitamura, and Daisuke Chugo
- Subjects
Engineering ,Rehabilitation ,Body posture ,business.industry ,Controller (computing) ,media_common.quotation_subject ,medicine.medical_treatment ,Force sensor ,Medical robotics ,Human–computer interaction ,medicine ,Manipulator ,Function (engineering) ,business ,Simulation ,media_common - Abstract
This paper proposes a robotic walker system with standing and walking assistance function. Our system focuses on domestic use for aged person who needs nursing in their daily life. Our key ideas are two topics. The first topic is combination of standing assistance function and walking assistance function. In previous works, many assistance devices are specialized in only ldquostanding-up operationrdquo or ldquowalking operationrdquo. However, in their daily life, elderly person needs standing, walking and seating assistance continuously by a same device. Our developing assistance system can support both operations by a small sized mechanism with low cost for domestic use. The second topic is steady standing assistance operation using an assistance manipulator and an active walker. In order to use the remaining physical strength of the patient, it is required to maintain the patientpsilas body posture which enables him to use own strength easily. According to the patientpsilas posture during standing up, our proposed system selects more appropriate device and controller, and realizes the standing assistance with steady posture of the patient based on the nursing specialists. The performance of our proposed system is verified by experiments using our prototype.
- Published
- 2008
- Full Text
- View/download PDF
35. Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis
- Author
-
Hideo Kobayashi, Yukihito Kabuyama, Shigeo Aota, Takuya Kitamura, Shinichi Kikuchi, Miwako K. Homma, Akihisa Kamataki, and Yoshimi Homma
- Subjects
Adult ,Male ,CD3 Complex ,Physiology ,Lymphocyte ,medicine.medical_treatment ,Recombinant Fusion Proteins ,T-Lymphocytes ,Arthritis ,Disease ,Ephrin-B1 ,Lymphocyte Activation ,Arthritis, Rheumatoid ,Mice ,Osteoarthritis ,medicine ,Animals ,Humans ,RNA, Messenger ,Phosphorylation ,Promoter Regions, Genetic ,Cells, Cultured ,Aged ,Mice, Inbred BALB C ,business.industry ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Synovial Membrane ,Chemotaxis ,Cell Biology ,DNA Methylation ,Fibroblasts ,Middle Aged ,medicine.disease ,Arthritis, Experimental ,Chemotaxis, Leukocyte ,Disease Models, Animal ,medicine.anatomical_structure ,Cytokine ,Rheumatoid arthritis ,DNA methylation ,Immunology ,Experimental pathology ,Cytokines ,Tyrosine ,CpG Islands ,Female ,business - Abstract
Although the etiology of early events in rheumatoid arthritis (RA) remains undefined, an anomaly in T cell homeostasis and hyperproliferation of synovial-lining cells are involved in the disease process. Since it has been reported that the ephrin/Eph receptor system plays important signaling roles in inflammation processes, we attempted to examine ephrinB molecules in T cells and synovial cells derived from RA in this study. The expression level of ephrinB1 was significantly high in synovial fibroblasts and CD3-positive exudate lymphocytes in synovial tissues derived from patients with RA compared with those in osteoarthritis (OA). Protein and mRNA levels of ephrinB1 were also higher in peripheral blood lymphocytes (PBLs) prepared from patients with RA than those from normal controls. Similar results were obtained from an animal model of human RA, collagen antibody-induced arthritis mice. Moreover, a recombinant ephrinB1/Fc fusion protein stimulated normal PBLs to exhibit enhanced migration and production of TNF-α. EphrinB1/Fc also activated synovial cells established from patients with RA to produce IL-6. Tyrosine phosphorylation of EphB1 was induced in these cells by ephrinB1/Fc. The CpG islands in the 5′ upstream regulatory region of the ephrinB1 gene were hypomethylated in RA patients compared with those of normal donors. These results suggest that ephrinB1 and EphB1 receptors play an important role in the inflammatory states of RA, especially by affecting the population and function of T cells. Inhibition of the ephrinB/EphB system might be a novel target for the treatment of RA.
- Published
- 2007
36. Steady standing assistance using active walker function
- Author
-
Daisuke Chugo, Takuya Kitamura, Kunikatsu Takase, and Songmin Jia
- Subjects
Engineering ,business.industry ,Function (mathematics) ,Linkage (mechanical) ,Motion control ,Stability (probability) ,Motion (physics) ,law.invention ,Mechanism (engineering) ,Control theory ,law ,Range (statistics) ,business ,Simulation ,Zero moment point - Abstract
In our current research, we are developing a force assistance system for standing up motion. Our developing walker system realizes the standing up motion using the support pad with three degrees of freedom which is actuated by our proposed linkage mechanism. Furthermore, our walker system has a mobile function. In this paper, we develop the control scheme which realizes the natural standing up motion with safety and stability. For developing control scheme, we measure the typical standing up motion by the nursing specialist as control reference. In order to maintain the stability of the patients during this motion, it is required to move the zero moment point into the range of his foot. Therefore, we propose the novel control scheme for standing up motion using active walker function. The performance of our proposed control scheme is experimented by computer simulations.
- Published
- 2007
- Full Text
- View/download PDF
37. Involvement of EphB1 receptor/EphrinB2 ligand in neuropathic pain
- Author
-
Miho Sekiguchi, Shinichi Konno, Takuya Kitamura, Yukihito Kabuyama, Hideo Kobayashi, Shinichi Kikuchi, Miwako K. Homma, and Yoshimi Homma
- Subjects
Receptor, EphB1 ,Down-Regulation ,Ephrin-B2 ,Rats, Sprague-Dawley ,medicine ,Animals ,Orthopedics and Sports Medicine ,Neurons, Afferent ,Peripheral Nerves ,RNA, Small Interfering ,business.industry ,Erythropoietin-producing hepatocellular (Eph) receptor ,Peripheral Nervous System Diseases ,Nerve injury ,medicine.disease ,Spinal cord ,Rats ,Disease Models, Animal ,Peripheral neuropathy ,medicine.anatomical_structure ,Spinal Cord ,Hyperalgesia ,Spinal nerve ,Anesthesia ,Neuropathic pain ,Synaptic plasticity ,NMDA receptor ,Neuralgia ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Neuroscience - Abstract
Study design We investigated involvement of EphB/ephrinB system in neuropathic pain. Objective Using immunoblotting, immunohistochemistry, and RNA interference techniques, we examined the expression levels of EphB receptors and ephrinB ligands in neuropathic pain. We also explored the effect of ephrinB siRNA for neuropathic pain. Summary of background data It has been reported that EphB2 regulates the development of synaptic plasticity in the hippocampus by interacting with N-methyl-D-aspartate (NMDA) receptors. In acute pain models, it has been clear that EphB1/ephrinB2 interactions via the NMDA receptor modulates synaptic efficacy in spinal cord. Methods Adult female Sprague-Dawley rats were used in this study. A crush injury model was prepared by crushing the left L5 spinal nerve distal to dorsal root ganglions (DRG) under deep anesthesia. The sham operation was subjected as control. Expression of ephrinB2 and EphB1 were examined by immunoblotting and immunohistochemical analyses with anti-EphB and anti-ephrinB antibodies. To assess involvement of ephrinB in neuropathic pain, we examined the effect of small interference RNA (siRNA) on mechanical allodynia. Results Among EphB and ephrinB isoforms tested, ephrinB2 and EphB1 were predominant in DRG and spinal cord. Results showed that the expression of ephrinB2 was enhanced in neurons in DRG and spinal cord by the injury in a time-dependent manner. EphB1 was expressed in neurons of spinal cord. Administration of ephrinB2 siRNA reduced the expression of ephrinB2 and mechanical allodynia. Conclusion Expression of ephrinB2 is enhanced by nerve injury in neurons in DRG and spinal cord, while its receptor EphB1 is expressed in spinal cord. These results suggest that induction of ephrinB2 might activate EphB1/ephrinB2 signaling pathway to regulate synaptic plasticity and reorganization, and that ephrinB2 siRNA could be a potential therapeutic agent for neuropathic pain.
- Published
- 2007
38. Serum interleukin-18 levels are associated with nephropathy and atherosclerosis in Japanese patients with type 2 diabetes
- Author
-
Tatsuaki Nakatou, Tatsuya Itoshima, Makoto Hiramatsu, Jun Wada, Takuya Kitamura, Kenichi Shikata, Akihiko Nakamura, and Hirofumi Makino
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Renal function ,Blood Pressure ,Type 2 diabetes ,Diabetic angiopathy ,Nephropathy ,Body Mass Index ,Diabetic nephropathy ,Japan ,Reference Values ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Diabetic Nephropathies ,Aged ,Advanced and Specialized Nursing ,business.industry ,Interleukin-6 ,Interleukin-18 ,Middle Aged ,medicine.disease ,Atherosclerosis ,Endocrinology ,Diabetes Mellitus, Type 2 ,Disease Progression ,Regression Analysis ,Interleukin 18 ,Female ,business ,Biomarkers ,Diabetic Angiopathies ,Kidney disease - Abstract
OBJECTIVE—Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardiovascular diseases. This study aimed to test the hypothesis that the serum level of IL-18 is a common predictor of nephropathy and atherosclerosis in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS—Eighty-two Japanese patients with type 2 diabetes and 55 age- and sex-matched healthy control subjects were enrolled. Patients with renal dysfunction (creatinine clearance RESULTS—Serum and urinary IL-18 levels were significantly elevated in patients with type 2 diabetes as compared with control subjects (serum IL-18 179 ± 62 vs. 121 ± 55 pg/ml, P < 0.001; urinary IL-18 97 ± 159 vs. 47 ± 54 pg/ml, P = 0.035). Univariate linear regression analysis showed significant positive correlations between serum IL-18 and AER (r [correlation coefficient] = 0.525, P < 0.001), HbA1c (r = 0.242, P = 0.029), high-sensitivity C-reactive protein (hs-CRP) (r = 0.240, P = 0.031), and urinary β-2 microglobulin (r = 0.235, P = 0.036). Serum IL-18 levels also correlated positively with carotid IMT (r = 0.225, P = 0.042) and baPWV (r = 0.232, P = 0.040). We also found a significant correlation between urinary IL-18 and AER (r = 0.309, P = 0.005). Multivariate linear regression analysis showed that AER (standard correlation coefficients [B] = 0.405, P < 0.001) and hs-CRP (B = 0.207, P = 0.033) were independently associated with serum IL-18 levels. AER was also independently associated with urinary IL-18 levels (B = 0.295, P = 0.005). Moreover, serum and urinary IL-18 levels correlated positively with AER after 6 months (r = 0.489, P < 0.001 and r = 0.320, P = 0.005) and changes in AER during the follow-up period (r = 0.268, P = 0.018 and r = 0.234, P = 0.042). CONCLUSIONS—Serum levels of IL-18 might be a predictor of progression of diabetic nephropathy as well as cardiovascular diseases.
- Published
- 2005
39. Restructuring the Ikeda City school urinary screening system: report of a screening survey
- Author
-
Ichiro Maki, Keiko Sakamoto, Takayuki Fukui, Seiko Asano, Takuya Kitamura, Satoko Yamamoto, Nobuyuki Kajiwara, Mikito Inoue, Takato Ueoka, Shinichiro Murakami, Kazuyuki Hayashi, Shigeki Hayashi, Kensuke Senzaki, and Maiko Yoshimoto
- Subjects
medicine.medical_specialty ,Specialist referral ,Restructuring ,business.industry ,Research ,education ,General physician ,Public Health, Environmental and Occupational Health ,Chronic glomerulonephritis ,Urinary protein/creatinine ratio ,Family medicine ,Chronic nephritic syndrome ,Prevalence ,medicine ,School urinary screening ,Renal biopsy ,Family Practice ,business ,School system - Abstract
Background Annual urinary screening is conducted at municipal kindergartens, elementary schools, and junior high schools in Ikeda City, Osaka, Japan (Ikeda City School System), and the results are reviewed by a general physician, but standards for when to recommend specialist referral have not been clear. Methods In all children attending the Ikeda City School System in 2012, dipstick urinalysis of a first-morning urine specimen was recommended once or twice, and if a second urinalysis showed proteinuria (≥1+), the urinary protein/creatinine ratio was measured. If this showed ≥0.2 g/g of creatinine (g/gCr), it was recommended that the child be evaluated by a specialist at Ikeda City Hospital. Results Urinary screening was performed in about 20% (388) of kindergarten, about 90% (5363) of elementary school, and about 86% (2523) of junior high school children living in Ikeda City. Urine samples were obtained from 387, 5349, and 2476 children, respectively. The urinary protein/creatinine ratio was ≥0.2 g/gCr in 13 children, including 1 elementary and 12 junior high children. In these 13 children, chronic nephritic syndrome (CNS) was suspected in 6 junior high school children, and of these, this was a new finding in 5, and renal biopsy was indicated in 3. In Ikeda City, the prevalence of CNS in elementary school children was
- Published
- 2013
- Full Text
- View/download PDF
40. Abstract 1331: The BK5.erbB2 mouse as a novel model of esophageal adenocarcinoma
- Author
-
John DiGiovanni, Kaoru Kiguchi, Yoshimi Homma, and Takuya Kitamura
- Subjects
Cancer Research ,medicine.medical_specialty ,Pathology ,Bile acid ,business.industry ,medicine.drug_class ,Cancer ,Intestinal metaplasia ,Esophageal cancer ,medicine.disease ,Gastroenterology ,medicine.anatomical_structure ,Oncology ,Internal medicine ,GERD ,medicine ,Adenocarcinoma ,Esophagus ,business ,CDX2 - Abstract
The incidence of esophageal adenocarcinoma (EAC) is rising rapidly throughout the Western world, and is associated with gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE). BE is intestinal metaplasia of squamous esophageal epithelium, important clinically due to the fact that it increases an individual's chance of progression to EAC 30 to 125-fold higher than people without BE. Despite its clinical importance, the molecular pathogenesis of BE is poorly understood. One limitation in the study of BE pathogenesis has been the lack of suitable experimental models. There is a critical need to develop good preclinical models of BE. ErbB2 was reported to be amplified and overexpressed in BE, EAC, and esophageal squamous cell carcinoma (ESCC). However, the role of erbB2 in the development and progression of esophageal cancer is still unknown. In this study, we utilized BK5.erbB2 mice, in which erbB2 is overexpressed in epithelial cells under the control of the bovine keratin 5 promoter to determine whether the interaction between erbB2 and bile acids is important in the etiology of esophageal cancers. BK5.erbB2 mice (2 months of age, n=8) and age matched wild type mice (n=10) were treated with porcine bile extract (10mg/mouse in 200μL water), taurochenodeoxycholate (TCDC) (0.1μmol/mouse in 200μL water), or water control, 3 times weekly for 14 weeks by gavage. In the BK5.erbB2 mice, exophytic tumors in the forestomach, which has the same histological structure of esophagus, were observed in 20%, 33%, and 0% of mice treated with bile extract, TCDC, and water control, respectively. No tumors were observed in wild type mice. All tumors observed in BK5.erbB2 mice were diagnosed as SCC. Western blotting analysis demonstrated that the bile acid treatment increased the levels of p-EGFR, p-MAPK, and p-Akt in the forestomachs of the BK5.erbB2 mice. Furthermore, CDX2 (a marker of BE) was significantly expressed in BK5.erbB2 mice treated with bile extract or TCDC. No development of intestinal metaplasia in forestomach was found. We further investigated using a surgically manipulated reflux model. Eleven 7 week-old BK5.erbB2 and 5 wild type mice were given an esophagogastroduodenostomy. Mice were sacrificed at post-operative week 8, and examined histologically. Hyperkeratosis and intestinal metaplasia were observed at the anastomosis sites in both BK5.erbB2 and wild type mice. These histological changes were more prominent in BK5.erbB2 mice. Interestingly, dysplastic lesions were observed only in BK5.erbB2 mice. These results indicate that more persistent exposure of bile via surgery induce the development of not only SCC, but also precancerous lesions of adenocarcinoma in the esophagus/forestomach of BK5.erbB2 mice. The interaction between erbB2 and bile acids is important in esophageal tumor formation and intestinal metaplasia. A surgical model using BK5.erbB2 mice could possibly be a promising model for the study of the development of EAC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1331. doi:1538-7445.AM2012-1331
- Published
- 2012
- Full Text
- View/download PDF
41. Abstract 4176: Bile acid-promoted esophageal and forestomach carcinomas in BK5.erbB2 mice
- Author
-
Kaoru Kiguchi, Kevin Connolly, Takuya Kitamura, John DiGiovanni, and Aline Lueckgen
- Subjects
Cancer Research ,medicine.medical_specialty ,Pathology ,Bile acid ,business.industry ,medicine.drug_class ,Stomach ,Cancer ,Stratified squamous epithelium ,Hyperplasia ,Esophageal cancer ,medicine.disease ,Gastroenterology ,medicine.anatomical_structure ,Oncology ,Internal medicine ,Medicine ,Gastric acid ,Esophagus ,business - Abstract
Esophageal cancer is considered to be one of the most lethal cancers, with a 5-year survival rate of approximately 23% to 50% for patients, even after complete resection with lymph node dissection. There are two common forms of esophageal cancer: squamous cell carcinomas (ESCCs) and adenocarcinomas (EACs). It has been shown that the initial step in the development of EACs is the transformation of normal stratified squamous epithelium in the lower esophagus to metaplastic specialized columnar epithelium (SCE), a pathological condition caused by chronic gastroesophageal reflux of gastric acid and bile known as Barrett's esophagus (BE), and it is possible that this condition also leads to the development of ESCCs as well. Although it has been reported that erbB2 is strongly expressed in SCE, EACs, and ESCCs, the role of erbB2 in the development and progression of esophageal cancer is still unknown. Furthermore, the contribution of bile acids in the etiology of esophageal cancer has not been explored. In this study, to determine whether interaction between erbB2 and bile acids is important in the etiology of esophageal cancers, we utilized BK5.erbB2 mice, in which erbB2 is overexpressed in epithelial cells under the control of the bovine keratin 5 promoter. Eight two-month-old homozygous BK5.erbB2 mice and 8 wild type mice were initiated with N-nitrosomethylbenzylamine (NMBA, 50μg/mouse in 200μL water, twice weekly for 3 consecutive weeks). Mice were then treated with porcine bile extract (10mg/mouse in 200μL water, 3 times weekly for 4 weeks) by gavage. Mice were sacrificed 24 hours after the last treatment and histopathological analyses in the esophagus, forestomach, squamocolumnar junction within the glandular stomach, and other tissues were performed. In wild type mice, only 20% of mice treated with NMBA/bile extract developed small papillomas in the forestomach and squamocolumnar junction at the stomach. In BK5.erbB2 mice, 50% of mice treated with bile extract alone developed significant hyperplasia, 63% of mice treated with NMBA alone developed papillomas, and 100% of mice treated with NMBA/bile extract developed large SCCs in these areas. BK5.erbB2 mice treated with bile extract also showed significantly elevated levels of cell proliferation as determined by 5-bromo-2′-deoxyuridine incorporation in esophagus and forestomach compared to wild type mice. These results indicate that bile acids may play an important role in the development of stomach/esophageal tumors where erbB2 is overexpressed and/or activated. In this regard, bile acids may promote the development of these tumors. Furthermore, these studies demonstrate the utility of the BK5.erbB2 mouse as a novel model for human stomach and esophageal cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4176.
- Published
- 2010
- Full Text
- View/download PDF
42. Periodontal therapy by local delivery of minocycline. Clinical study of periodontal therapy by LS-007
- Author
-
Keiji KURIMOTO, Osamu ISOSHIMA, Yuka NAORA, Takashi ANADA, Yoshitomo KOBAYASHI, Mitsuharu KOBAYASHI, Hideo ARAI, Shogo TAKASHIBA, Hideki NANBA, Masayuki YOKOYAMA, Yuka MITSUDA, Yumi MIZUSHIMA, Yoshio NOMURA, Yoji MURAYAMA, Masatoshi UEDA, Yoshihiro TERANISHI, Kazuyuki FUJIWARA, Akiko HASHIZUME, Shinpei KAMAYA, Yoko HOSOYAMA, Kenji UEBA, Kazuyuki ONISHI, Takeo SHIRAI, Satoshi OHASHI, Hirosuke HIGASHI, Yoshifumi KIOKA, Shigeyoshi MINAMIBAYASHI, Mayumi TANAKA, Takuya KITAMURA, Kazuto MAKIGUSA, Akira YAMAOKA, Ryoji URAGUCHI, Satsuki HAGIWARA, Mitsuo FUKUDA, Sigeru ODA, Cherng-Jong LIN, Wataru TAKEFUTA, Toyotsune MERA, Daizou MINEGISHI, Makoto UMEDA, Hiroshi NAKAMOTO, Hirofumi INATOMI, Narongsak Laosrisin, Toshihide NOGUCHI, and Isao ISHIKAWA
- Subjects
medicine.medical_specialty ,business.industry ,MEDLINE ,Dentistry ,Minocycline ,Ointments ,Clinical study ,Tetracyclines ,Internal medicine ,Anti-Infective Agents, Local ,Humans ,Medicine ,business ,Periodontal Diseases ,Tablets ,medicine.drug - Abstract
塩酸ミノサイクリン (MINO, 日本レダリー, 東京) を用いて歯周炎の局所治療法を確立するための研究を行なってきた。本研究は, MINOを2% (力価) に含有する軟膏製剤 (LS-007) を臨床的に用い, その有効性, 安全性ならびに有用性をもとに用法を検討したものである。4mm以上のポケットを有する辺縁性歯周炎患者45名の119歯を被験歯とし, LS-007とそのプラセボ, および市販のミノマイシン錠 (日本レダリー) を用い, 微生物学的および臨床的に用法を検討した。その結果, LS-007の局所投与は歯周病治療において, 臨床的有効性, 安全性および有用性があると結論した。
- Published
- 1988
- Full Text
- View/download PDF
43. Feature Selection and Fast Training of Subspace Based Support Vector Machines
- Author
-
Shigeo Abe, Syogo Takeuchi, and Takuya Kitamura
- Subjects
business.industry ,Feature vector ,Feature selection ,Pattern recognition ,Machine learning ,computer.software_genre ,Support vector machine ,Random subspace method ,Dimension (vector space) ,Least squares support vector machine ,Sequential minimal optimization ,Artificial intelligence ,business ,computer ,Subspace topology ,Mathematics - Abstract
In this paper, we propose two methods for subspace based support vector machines (SS-SVMs) which are subspace based least squares support vector machines (SSLS-SVMs) and subspace based linear programming support vector machines (SSLP-SVMs): 1) optimum selection of the dictionaries of each class subspace from the standpoint of classification separability, and 2) speeding up training SS-SVMs. In method 1), for SSLS-SVMs, we select the dictionaries with optimized weights, and for SSLP-SVMs, we select the dictionaries without non-negative constraints. In method 2), the empirical feature space is obtained by using only the training data belonging to a class instead of using all the training data. Thus the dimension of the empirical feature space and training cost become lower. We demonstrate the effectiveness of the proposed methods over the conventional method for two-class bench mark datasets.
44. Emergency cholecystectomy for patients on antiplatelet therapy
- Author
-
Takuya Kitamura, Ayumi Takaoka, Shinji Tanaka, Takanori Ochiai, Daisuke Ban, Atsushi Kudo, Minoru Tanabe, and Keiichi Akahoshi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Blood transfusion ,medicine.medical_treatment ,Treatment outcome ,Cholecystitis, Acute ,03 medical and health sciences ,0302 clinical medicine ,Blood loss ,medicine ,Humans ,Cholecystectomy ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Gallbladder ,Incidence (epidemiology) ,Patient Selection ,Anticoagulants ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,Cholecystitis ,030211 gastroenterology & hepatology ,Female ,Emergencies ,business ,Platelet Aggregation Inhibitors - Abstract
The use of antiplatelet therapy (APT) and/or anticoagulant therapy (ACT) continues to increase due to the aging population. Because the management of patients with acute cholecystitis receiving APT/ACTis still unclear, surgeons are sometimes faced with the difficult decision to delay surgery. We aimed to analyze characteristics and surgical risks of patients who underwent emergency cholecystectomy for acute cholecystitis without discontinuing APT. We conducted a retrospective review of 113 patients between 2006 and 2014. Treatment outcomes among 13 patients who underwent cholecystectomy without discontinuing APT (the cAPT group), 11 patients who discontinued APT and ACT (the D group), and 89 patients who did not receive preoperative APT and/or ACT (the No APT group) were compared. There were no significant differences in intraoperative blood loss, conversion to open surgery, and bleeding-related complications. However, the incidence of intraoperative blood transfusion was higher in the cAPT group (P = 0.04). They presented with severe local inflammation; thus, it was difficult to stop bleeding from the gallbladder bed. Hemostatic tools for liver surgery were used to control bleeding. Emergency cholecystectomy was tolerable for patients with acute cholecystitis while continuing APT. However, in case of severe local inflammation, there is a greater risk for massive hemorrhage.
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