1. Diagnosis, natural course and treatment outcomes of groove pancreatitis
- Author
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T. Nykänen, Leena Kylänpää, Ville Sallinen, Arto Kokkola, Helka Parviainen, J. Kuronen, Jukka Sirén, Timo Tarvainen, II kirurgian klinikka, Helsinki University Hospital Area, HUS Abdominal Center, Hyvinkää Hospital Area, Research Programs Unit, HUS Medical Imaging Center, Department of Surgery, Clinicum, Pertti Panula / Principal Investigator, and Department of Anatomy
- Subjects
Diagnostic Imaging ,Male ,medicine.medical_specialty ,FEATURES ,Population ,Asymptomatic ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,PARADUODENAL PANCREATITIS ,CYSTIC DYSTROPHY ,Pancreatitis, Chronic ,Internal medicine ,medicine ,Humans ,Medical diagnosis ,education ,Retrospective Studies ,education.field_of_study ,Hepatology ,business.industry ,Gastroenterology ,Cancer ,Middle Aged ,3126 Surgery, anesthesiology, intensive care, radiology ,medicine.disease ,3. Good health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Radiological weapon ,Cohort ,Pancreatitis ,030211 gastroenterology & hepatology ,Histopathology ,medicine.symptom ,DUODENAL WALL ,business - Abstract
Background Groove pancreatitis (GP) is a rare form of chronic pancreatitis with limited data on its diagnostics and treatment outcomes. The aim of this study was to assess its diagnostics, natural course, and treatment options. Methods The study is a retrospective population-based study from Southern Finland, including all patients with suspected GP between January 2005 and December 2015. Two certified gastrointestinal radiologists re-reviewed the imaging studies. The radiological re-review, clinical judgment, and final histopathology confirmed the GP diagnoses. Results Out of 67 patients with possible GP, 39 patients were considered to have high radiological certainty of GP. Out of these 39, five patients had cancer instead. Thirty-three patients with confirmed GP formed the final study cohort. Patients with GP were mostly middle-aged (median 55 years) men. All had at least moderate alcohol consumption. No intervention was needed in 14 patients. In five-year follow-up all conservatively treated patients became asymptomatic, while 10 out of 16 patients undergoing at least one intervention were asymptomatic at five years. Conclusion The radiological diagnosis of GP is difficult, and a low threshold for cancer suspicion should be kept. Symptoms of GP decrease with time and suggest conservative treatment as the first-line option.
- Published
- 2021
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