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The results of the study on the comparative assessment of different tillage methods in the field crop rotation with different levels of mineral nutrition (N30P30 and N60P30 kg of active ingredient/ ha) are presented. The experiment was carried out on low-humus low-carbonate chernozem of the forest-steppe zone of Eastern Trans-Baikal Territory in 2012–2014. The zoned variety of Buryatskaya-79 spring wheat, and Metis oat variety were used for sowing. Low-cost methods of soil tillage were studied, providing for the preservation and improvement of soil fertility, an increase in the productivity of grain and fodder crops, and a decrease in material and energy costs. Replacement of the basic tillage with a PN-4-35 plow with a ring roller in the third and fourth crop rotation fields by surface tillage with a Stepnyak-7.4 cultivator and direct sowing on the stubble with a PPM Ob4-ZT seeder when applying mineral fertilizers at a rate of N60P30 kg of active ingredient/ha had a positive effect on the condition of the soil. The following indicators of soil fertility were achieved: structural coefficient 1.28–1.38, organic matter content 3.15–3.33%, productive moisture content in the 0–50 cm layer 29.2–31.8 mm, the release of carbon dioxide 1.810–1.969 kg per 1 hour, the content of Р2О5 in the 0–20 cm layer 71–96 mg/kg of soil, the content of K2O – 57–82 mg/kg of soil. An increase in the yield of oat grain of 0.16–0.21 t/ha, the green mass of annual grasses of 3.44.0 t/ha, the collection of feed units of 0.32–0.34 t/ha, a reduction in the cost of fuel and lubricants by 31.2-36.4%, and an increase in profitability by 25.0–40.3% were achieved.

The possibility of increasing the yield of fodder-grain crops in single-species agrocenoses to provide livestock with nutritious highquality feed was studied. The results of field and laboratory studies (2016–2018) on the cultivation of traditional (barley, oats, spring and winter rye) and uncommon fodder crops (triticale, corn) sown as single crops in the forest-steppe zone of Trans-Baikal Territory are presented. The objects of the research were the following recognized varieties of the crops under study: local winter rye Zhitkinskaya, spring rye Onokhoyskaya, oats Metis, barley Anna, triticale Ukro, corn hybrid Obsky 150 CB. The experiment was conducted on meadow chernozem mealy-carbonate soil (light loam by particle size distribution). Poaceous fodder crops were assessed in terms of their adaptability to growing conditions, yield and nutritional value of grain. Their economically valuable characteristics were shown. On average over the years of research, when cultivating traditional and uncommon poaceous crops for fodder grain in single-crop sowings, triticale and corn had an advantage. The grain yield in the experiment was 3.0-5.8 t/ha, collection of fodder units – 3.39-6.13 t/ha, digestible protein 287-494 kg/ha, gross energy – 34.7-60.5 GJ/ha, availability of digestible protein – 85–77 g per one feed unit. Traditional crops were inferior to uncommon crops in terms of grain yield by 0.5-3.3 t/ ha, (on average for the variants of the experiment), feed units – by 0.99-3.73 t/ha, digestible protein – by 85-292 kg/ha, gross energy – by 0.99–35.7 GJ/ha.

A newly developed recombinant factor IX (BAX326(1) ) was investigated for prophylactic use in paediatric patients aged12 years with severe (FIX level1%) or moderately severe (FIX level 1-2%) haemophilia B. The aim of this prospective clinical trial was to assess the safety, haemostatic efficacy and pharmacokinetic profile of BAX326 in previously treated paediatric patients. BAX326 was administered as prophylaxis twice a week for a period of 6 months, and on demand for treatment of bleeds. Safety was assessed by the occurrence of related AEs, thrombotic events and immunologic assessments. Efficacy was evaluated by annualized bleeding rate (ABR), and by treatment response rating (excellent, good, fair, none). PK was assessed over 72 h. None of the 23 treated paediatric subjects had treatment-related SAEs or AEs. There were no thrombotic events, inhibitory or specific binding antibodies against FIX, rFurin or CHO protein. Twenty-six bleeds (19 non-joint vs. 7 joint bleeds) occurred (mean ABR 2.7 ± 3.14, median 2.0), of which 23 were injury-related. Twenty subjects (87%) did not experience any bleeds of spontaneous aetiology. Haemostatic efficacy of BAX326 was excellent or good for96% of bleeds (100% of minor, 88.9% of moderate and 100% of major bleeds); the majority (88.5%) resolved after 1-2 infusions. Longer T1/2 and lower IR were observed in younger children (6 years) compared to those aged 6 to 12 years. BAX326 administered as prophylactic treatment as well as for controlling bleeds is efficacious and safe in paediatric patients aged12 years with haemophilia B.

Background Vatreptacog alfa, a recombinant factor VIIa (rFVIIa) analog with three amino acid substitutions and 99% identity to native FVIIa, was developed to improve the treatment of hemophilic patients with inhibitors. Objectives To confirm the safety and assess the efficacy of vatreptacog alfa in treating bleeding episodes in hemophilic patients with inhibitors. Patients and methods In this international, multicenter, randomized, double-blind, active-controlled, crossover, confirmatory phase III trial (adept™2) in patients with hemophilia A or B and inhibitors, bleeds were randomized 3 : 2 to treatment with vatreptacog alfa (one to three doses at 80 μg kg−1) or rFVIIa (one to three doses at 90 μg kg−1). Treatment failures after three doses of trial product (TP) were managed according to the local standard of care. Results In the 72 patients enrolled, 567 bleeds were treated with TP. Both vatreptacog alfa and rFVIIa gave 93% effective bleeding control at 12 h. Vatreptacog alfa was superior to rFVIIa in secondary efficacy outcomes, including the number of doses used to treat a bleed and sustained bleeding control 24–48 h after the first dose. Eight patients (11%) developed antibodies against vatreptacog alfa, including four with cross-reactivity against rFVIIa and one with an in vitro neutralizing effect to vatreptacog alfa. Conclusions This large randomized controlled trial confirmed the well-established efficacy and safety profile of rFVIIa, and showed that vatreptacog alfa had similar or better efficacy than rFVIIa. However, because of the development of anti-drug antibodies, a positive benefit–risk profile is unlikely to be achieved with vatreptacog alfa.

The paper is devoted to the Great Britain's stance on the promoting of European integration towards creation of a federal state, after the euro crisis. It focuses on advantages and losses of the British policy in the EU. There are standpoints and views of four main political parties of Great Britain on the country's secession from the EU as well as the results of both local elections and elections for the European Parliament which reveal the rise of the right secessionist and anti-European moods in British society. The author also considers the European nations' present views and attitudes to the European idea. The following questions are answered in the article: Do the anti-European moods exert the crucial and lasting effect on British European policy? Is it better and more profitable for Britain to stay within the organization taking an active part in the integration process, or to withdraw from it?

The examination of residents of St. Petersburg and Petrozavodsk revealed a high frequency of vitamin D deficiency and according to the criteria of the International Society of Endocrinology (ENDO, 2011), normal levels of vitamin D sufficiency had only 16.8% of residents of the north-western region of the Russian Federation, while vitamin D insufficiency was seen in 37.5%, and deficit — in 45.7% of patients. When reviewing the results using the criteria proposed by the U.S. Institute of Medicine (IOM, 2011), normal values of 25(OH)D in serum were detected in 49.6% insufficient levels — in 40.0% and deficit — in 10.4%. The decrease ofvitamin D levels was independent of age, but more frequent in women and people who are overweight. Given the lack of national standards for assessing the sufficiency ofvitamin D, as well as the average level of 25(OH)D in the blood serum in the study population, to assess vitamin D status in the northwestern region of Russia is preferable to use the criteria proposed by the U.S. Institute of Medicine in 2011.

Summary Some progress has been made regarding availability of recombinant factor VIII concentrates and prophylaxis for haemophilia A in emerging countries, where plasma-derived concentrates were used in the vast majority. Clinical studies to document their introduction and effectiveness are so far not widely available in literature. This non-interventional study evaluates the real-life effectiveness and safety of prophylactic and on-demand treatment with recombinant factor VIII formulated with sucrose (rFVIII-FS) for bleed control and preservation of joints in emerging countries from Eastern Europe, North Africa and Middle East area. One hundred and eighty-six patients from 11 countries were enrolled, mean ± SD age 12.8 ± 12.7 years. At enrolment, majority (79.6%) had severe haemophilia A (

Purpose To estimate the possibilities and indication for optico-reconstructive surgery after blockexcision of iridociliar tumors. Methods 68 patients with iridociliary tumors and complicated cataract were treated. 41 patients underwent combined surgery – block excision with cataract extraction (IOL implantation performed in 37 cases). In 14 of these patients iridectomy was performed using a tunnel corneal incision (in cases of small tumors of iris pupillary margin) followed by simultaneous phacoemulsification+IOL. The other patients underwent cataract extracapsular extraction. Simultaneous operations were carried out only in benign tumors. 27 patients underwent delayed cataract extraction after blockexcision (9 patients with malignant tumors, 18 patients - benign). In 5 cases surgery were performed with implantation of artificial iris, in 17 cases - with IOL implantation. Results In all cases we detected increase the visual acuity, depending on the type of surgery and the tumor’s sizes. Conclusion Indications for simultaneous optico-reconstructive surgery are benign tumors, for delayed – even malignant ones. In cases of small benign tumors of iris papillary margin simultaneous surgery could be done using FEC + IOL, for large benign tumors (no more than 1/3 of iris) – with simultaneous cataract extracapsular extraction, if more than 1/3 of iris – delayed surgery with implantation of artificial iris.

The effect of herpes simplex virus (HSV) and influenza virus (IV) on lipid metabolism was studied. In conditions of acute herpetic infection of rabbits we detected typical dyslipidemia, characterized by increased contents of total cholesterol, beta-cholesterol and triglycerides in the absence of trustworthy differences in concentrations of alpha-cholesterol. The use of antiherpetic preparation furavir, on the background of infection, corrected lipid spectrum of the infected animals. Blood lipid disturbances in acute influenza virus infection of mice were not detected. HSV infection of cell culture of human aorta was accompanied by increased accumulation of free lipids in cells. IV infection, in the same conditions of experiment, did not change the contents of intracellular lipids. The obtained data deepen the existing notions of herpetic and influenza infections pathogenesis and may be useful in understanding etiopathogenesis of certain somatic metabolism diseases.

Sleep disordered breathing (SDB) during pregnancy covers a diverse spectrum of pathological conditions provoked by physiological changes in maternal organism and growing fetus. Most of the symptoms (sleepiness, fatigue, vomiting, snoring, obstructed nasal breathing, etc.) are considered to be „normally“-related to the physiological changes during pregnancy. In fact, that subtle complains could be a harbinger of more complex disorders, which could remain neglected and undiagnosed by the consulting obstetric and gynecology specialist or primary physician. In view of the potential serious complications related to the SDB during pregnancy it is essential to consider even the mild complains of the pregnant woman as prospective alarming symptoms. Interdisciplinary consultation with otorhinolaryngologist and subsequent detailed polysomnographic study are essential for proper diagnosis in order to avoid possible life threatening complications.