Author: "T Yamashita" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"T Yamashita"' showing total 475 results

Start Over Author "T Yamashita" Topic business

475 results on '"T Yamashita"'

1. Clinical usefulness of a novel fluorescence technique for the intraoperative diagnosis of surgical margins in patients with breast cancer

Author: H Ueo, I Minoura, A Gamachi, T Doi, M Yamaguchi, T Yamashita, H Tsuda, T Moriya, R Yamaguchi, Y Kozuka, T Sasaki, T Masuda, Y Kai, Y Kubota, Y Urano, M Mori, and K Mimori
Subjects: medicine.medical_specialty, Intraoperative Care, Rhodamines, business.industry, MEDLINE, Margins of Excision, Breast Neoplasms, Mastectomy, Segmental, medicine.disease, Fluorescence, Breast cancer, Humans, Medicine, Female, Surgery, In patient, Radiology, business, Fluorescent Dyes
Abstract: In both 5- and 15-min data, FI was significantly higher in malignant tissues than in benign tissues. The diagnostic accuracy was similar at 5 and 15 min. Therefore, the 5-min FI was enough applying in the further analyses.
Published: 2021

2. Correlation between urinary incontinence and psychosis in patients with advanced‐stage Parkinson’s disease

Author: T. Yamashita, Tetsuro Sakamoto, Keiichi Nakahara, Yukio Ando, Kazutoshi Uekawa, Ryoichi Kurisaki, Shunya Nakane, and Tokunori Ikeda
Subjects: medicine.medical_specialty, Psychosis, Parkinson's disease, business.industry, Advanced stage, Urinary incontinence, medicine.disease, Neurology, Dyskinesia, Internal medicine, medicine, In patient, Neurology (clinical), medicine.symptom, business
Published: 2020

3. Técnica WALANT guiada por ultrassom na cirurgia de descompressão do túnel do carpo

Author: Danilo C. Chagas, Sandro Baraldi Moreira, and Caetano T. Yamashita
Subjects: Gynecology, medicine.medical_specialty, business.industry, Medicine, Orthopedics and Sports Medicine, Surgery, General Medicine, business
Abstract: ResumoA síndrome do túnel do carpo (STC) é a neuropatia compressiva mais comum do corpo humano. Seus sintomas decorrem da compressão do nervo mediano no carpo. O tratamento pode ser incruento, com medicações e/ou infiltrações que amenizam os sintomas, ou cruento, mais eficaz, com a descompressão do nervo mediano pela seção cirúrgica do retináculo dos flexores do carpo. A técnica anestésica varia de acordo com o serviço de anestesia: sedação, anestesia locorregional venosa e, mais recentemente, a anestesia local com o paciente acordado e sem torniquete (wide-awake local anesthesia no tourniquet, WALANT), que pode ser realizada pelo próprio cirurgião. Por utilizar anestesia local com vasoconstritor, essa técnica dispensa o uso de torniquete no membro superior e a necessidade de sedação. O bloqueio do nervo mediano na WALANT guiada por ultrassonografia confere melhor precisão à técnica, e mais segurança ao paciente, e, neste artigo seu uso na realização da descompressão do túnel do carpo é descrito, e a literatura, revisada.
Published: 2021

4. Safety outcomes from monarchE: phase 3 study of abemaciclib combined with endocrine therapy (ET) for the adjuvant treatment of HR+, HER-2-, node-positive, high risk, early breast cancer (EBC)

Author: Mattea Reinisch, T Yamashita, R. Broom, Ashwin Shahir, M. Gumus, Annamaria Zimmermann, Hope S. Rugo, B. San Antonio, Flora Zagouri, Chuan-gui Song, and Joyce O'Shaughnessy
Subjects: Oncology, medicine.medical_specialty, business.industry, Node (networking), medicine.medical_treatment, Endocrine therapy, Phases of clinical research, chemistry.chemical_compound, chemistry, Internal medicine, medicine, business, Abemaciclib, Adjuvant, Early breast cancer
Published: 2021

5. The relationship between vaginal cavernous hemangiomas and late pregnancy. A case report and a review of the literature

Author: S. Momose, N. Takayanagi, T. Yamashita, J. Tamaru, and M. Higashi
Subjects: medicine.medical_specialty, Reproductive Medicine, business.industry, Obstetrics, Obstetrics and Gynecology, Medicine, business, Late pregnancy, Cavernous hemangiomas
Published: 2019

6. Impact of Blood Pressure Visit‐to‐Visit Variability on Adverse Events in Patients With Nonvalvular Atrial Fibrillation: Subanalysis of the J‐RHYTHM Registry

Author: Eitaro Kodani, Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Toshiaki Otsuka, Hideki Origasa, H Inoue, K Okumura, H Atarashi, T Yamashita, M Sakurai, Y Kawamura, I Kubota, Y Kaneko, K Matsumoto, S Ogawa, Y Aizawa, I Kodama, E Watanabe, Y Koretsune, Y Okuyama, A Shimizu, O Igawa, S Bando, M Fukatani, T Saikawa, A Chishaki, H Origasa, N Kato, K. Kanda, J Kato, H Obata, M Aoki, H. Honda, Y Konta, T Hatayama, Y Abe, K Terata, T Yagi, A Ishida, T Komatsu, H Tachibana, H Suzuki, Y Kamiyama, T Watanabe, M Oguma, M Itoh, O Hirono, Y Tsunoda, K Ikeda, T Kanaya, K Sakurai, H Sukekawa, S Nakada, T Itoh, S Tange, M. Manita, M Ohta, H Eguma, R Kato, Y Endo, T Ogino, M Yamazaki, H Kanki, M Uchida, S Miyanaga, K Shibayama, N Toratani, T Kojima, M Ichikawa, M Saito, Y Umeda, T Sawanobori, H Sohara, S Okubo, T Okubo, T. Tokunaga, O Kuboyama, H Ito, Y Kitahara, K Sagara, T Satoh, E Kodani, K Sugi, Y Kobayashi, Y Higashi, T Katoh, Y Hirayama, N Matsumoto, M Takano, T Ikeda, S Yusu, S Niwano, Y Nakazato, Y Kawano, M Sumiyoshi, N Hagiwara, K Murasaki, H Mitamura, S Nakagawa, K Okishige, K Azegami, H Aoyagi, K Sugiyama, M Nishizaki, N Yamawake, I Watanabe, K Ohkubo, H Sakurada, S Fukamizu, M Suzuki, W Nagahori, T Nakamura, Y Murakawa, N Hayami, K Yoshioka, M Amino, K Hirao, A Yagishita, K Ajiki, K Fujiu, Y Imai, A Yamashina, T Ishiyama, M Sakabe, K Nishida, H Asanoi, H Ueno, null Lee, Y Mitsuke, H Furushima, K Ebe, M Tagawa, M Sato, M. Morikawa, K Yamashiro, K Takami, T Ozawa, M Watarai, M Yamauchi, H Kamiya, H. Hirayama, Y. Yoshida, T Murohara, Y Inden, H Osanai, N Ohte, T Goto, I Morishima, T Yamamoto, E Fujii, M Senga, H. Hayashi, T Urushida, Y Takada, N Tsuboi, T Noda, T Hirose, T Onodera, S Kageyama, T Osaka, T. Tomita, K Shimada, M Nomura, H Izawa, A Sugiura, T Arakawa, K. Kimura, T Mine, T Makita, H Mizuno, A Kobori, T Haruna, M Takagi, N Tanaka, H Shimizu, T Kurita, K Motoki, N Takeda, Y Kijima, M Ito, A Nakata, Y Ueda, A Hirata, S Kamakura, K Satomi, Y. Yamada, Y. Yoshiga, H Ogawa, M Kimura, T Hayano, T Kinbara, H Tatsuno, M Harada, K. Kusano, M Adachi, A Yano, M Sawaguchi, J Yamasaki, T Matsuura, Y Tanaka, H Moritani, T Maki, S Okada, M Takechi, T Hamada, A Nishikado, Y Takagi, I Matsumoto, T Soeki, Y Doi, M Okawa, H Seo, S Kitamura, K Yamamoto, M Akizawa, N Kaname, S Ando, S Narita, T Inou, Y Fukuizumi, K Saku, M Ogawa, Y Urabe, M Ikeuchi, S Harada, H Yamabe, Y Imamura, Y. Yamanouchi, K Sadamatsu, K Yoshida, T Kubota, N Takahashi, N Makino, Y Higuchi, T Ooie, T Iwao, K. Kitamura, T Imamura, K Maemura, N Komiya, M Hayano, H Yoshida, and K. Kumagai
Subjects: Male, medicine.medical_specialty, Hemorrhage, Risk Assessment, Rhythm, Japan, Risk Factors, Cause of Death, Thromboembolism, Internal medicine, Atrial Fibrillation, Ambulatory Care, medicine, Humans, Arrhythmia and Electrophysiology, In patient, Registries, Risk factor, Adverse effect, Original Research, Aged, Analysis of Variance, variability, Clinical events, business.industry, blood pressure, Anticoagulants, Blood Pressure Determination, Atrial fibrillation, medicine.disease, Blood pressure, major hemorrhage, Hypertension, Cardiology, Female, Warfarin, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract: Background Blood pressure (BP) variability has reportedly been a risk factor for various clinical events. To clarify the influence of BP visit‐to‐visit variability on adverse events in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed. Methods and Results Of 7406 outpatients with nonvalvular atrial fibrillation from 158 institutions, 7226 (age, 69.7±9.9 years; men, 70.7%), in whom BP was measured 4 times or more (14.6±5.0 times) during the 2‐year follow‐up period or until occurrence of an event, constituted the study group. SD and coefficient of variation of BP values were calculated as BP variability. Thromboembolism, major hemorrhage, and all‐cause death occurred in 110 (1.5%), 121 (1.7%), and 168 (2.3%) patients, respectively. When patients were divided into quartiles of systolic BP‐SD (P =0.015 for thromboembolism; HR, 2.60, 95% CI, 1.36–4.97, P =0.004 for major hemorrhage; and HR, 1.85, 95% CI, 1.11–3.07, P =0.018 for all‐cause death) after adjusting for components of the CHA 2 DS 2 ‐VASc score, warfarin and antiplatelet use, atrial fibrillation type, BP measurement times, and others. These findings were consistent when BP‐coefficient of variation was used instead of BP‐SD. Conclusions Systolic BP visit‐to‐visit variability was significantly associated with all adverse events in patients with nonvalvular atrial fibrillation. Further studies are needed to clarify the causality between BP variability and adverse outcomes in patients with nonvalvular atrial fibrillation. Registration URL: https://www.umin.ac.jp/ctr/ ; Unique Identifier: UMIN000001569.
Published: 2021

7. Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

Author: D. Miles, J. Gligorov, F. André, D. Cameron, A. Schneeweiss, C. Barrios, B. Xu, A. Wardley, D. Kaen, L. Andrade, V. Semiglazov, M. Reinisch, S. Patel, M. Patre, L. Morales, S.L. Patel, M. Kaul, T. Barata, J. O’Shaughnessy, Q. Zhang, Z. Shao, X. Wang, C. Geng, X. Yan, Z. Tong, K. Shen, Y. Yin, T. Sun, J. Yang, J. Feng, M. Yan, Y. Wang, Q. Liu, S. Zhang, M. De Laurentiis, A. Santoro, V. Guarneri, M. Colleoni, C. Natoli, L. Cortesi, S. Placido, L. Gianni, F. Ferrau, L. Livi, A. Zambelli, L. Del Mastro, G. Tonini, F. Montemurro, G. Bianchi, R. Pedersini, S. Prete, G. Allegrini, G. Naso, P. Vici, D. Loirat, A. Mailliez, F. Priou, O. Tredan, F. Dalenc, C. Perrin, M. Timar David, N. Dohollou, L. Teixeira, F. Brocard, A. Arnaud, S. Delaloge, J.-P. Spano, L. Mansi, F. Damian, J. Pedrini, S. Aleixo, R. Hegg, R. Junior, M. Schmidt, C. Wenzel, E.-M. Grischke, M. Just, N. Harbeck, C. Schumacher, U. Peters, D. Fischer, H. Forstbauer, R. Liersch, E. Warner, N. Bouganim, C. Doyle, J. Price Hiller, T. Vandenberg, M. Pavic, A. Robinson, G. Roldan Urgoiti, N. Califaretti, A. Alacacioglu, M. Gumus, B. Yalcin, I. Cicin, F. Kose, K. Uygun, M. Kaplan, E. Cubukcu, M. Harries, D. Doval, S. Gupta, P. Mohapatra, S. Chatterjee, N. Ghadyalpatil, M. Singhal, S. Nag, A. Agarwal, I. Wolf, E. Gal Yam, R. Yerushalmi, T. Peretz, G. Fried, N. Ben Baruch, D. Katz, E. Hamilton, F. Kayali, A. Brufsky, M. Telli, G. Wright, R. Oyola, T. Rakowski, S. Graff, S. Tjulandin, A. Aparicio, M. Ruiz Borrego, L. Merino, J. Guerra Martinez, E. Lopez, T. Yamashita, S. Ohtani, K. Inoue, Y. Ito, N. Niikura, T. Nakayama, Y. Sagara, Y. Yanagita, Y. Kamada, K. Kaneko, A. Nervo, A. Eniu, M. Schenker, P. Priester, B. Melichar, M. Zimovjanova, P. Sormova, J. Sufliarsky, M. Kakalejcik, R. Belbaraka, H. Errihani, D. Le Than, D. Pham, G. Aravantinos, C. Papadimitriou, G. Koumakis, C. Papandreou, P. Podolski, and K. Tabane
Subjects: 0301 basic medicine, Oncology, PD-L1, atezolizumab, medicine.medical_specialty, advanced breast cancer, immune checkpoint inhibitor, paclitaxel, triple-negative breast cancer, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Humans, Paclitaxel, Progression-Free Survival, Triple Negative Breast Neoplasms, medicine.medical_treatment, Population, Antibodies, 03 medical and health sciences, 0302 clinical medicine, Atezolizumab, Internal medicine, Monoclonal, Clinical endpoint, Medicine, Progression-free survival, education, Humanized, Triple-negative breast cancer, education.field_of_study, Chemotherapy, Taxane, business.industry, Hazard ratio, Hematology, 030104 developmental biology, 030220 oncology & carcinogenesis, business
Abstract: Background In the phase III IMpassion130 trial, combining atezolizumab with first-line nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) showed a statistically significant progression-free survival (PFS) benefit in the intention-to-treat (ITT) and programmed death-ligand 1 (PD-L1)-positive populations, and a clinically meaningful overall survival (OS) effect in PD-L1-positive aTNBC. The phase III KEYNOTE-355 trial adding pembrolizumab to chemotherapy for aTNBC showed similar PFS effects. IMpassion131 evaluated first-line atezolizumab–paclitaxel in aTNBC. Patients and methods Eligible patients [no prior systemic therapy or ≥12 months since (neo)adjuvant chemotherapy] were randomised 2:1 to atezolizumab 840 mg or placebo (days 1, 15), both with paclitaxel 90 mg/m2 (days 1, 8, 15), every 28 days until disease progression or unacceptable toxicity. Stratification factors were tumour PD-L1 status, prior taxane, liver metastases and geographical region. The primary endpoint was investigator-assessed PFS, tested hierarchically first in the PD-L1-positive [immune cell expression ≥1%, VENTANA PD-L1 (SP142) assay] population, and then in the ITT population. OS was a secondary endpoint. Results Of 651 randomised patients, 45% had PD-L1-positive aTNBC. At the primary PFS analysis, adding atezolizumab to paclitaxel did not improve investigator-assessed PFS in the PD-L1-positive population [hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.60-1.12; P = 0.20; median PFS 6.0 months with atezolizumab–paclitaxel versus 5.7 months with placebo–paclitaxel]. In the PD-L1-positive population, atezolizumab–paclitaxel was associated with more favourable unconfirmed best overall response rate (63% versus 55% with placebo–paclitaxel) and median duration of response (7.2 versus 5.5 months, respectively). Final OS results showed no difference between arms (HR 1.11, 95% CI 0.76-1.64; median 22.1 months with atezolizumab–paclitaxel versus 28.3 months with placebo–paclitaxel in the PD-L1-positive population). Results in the ITT population were consistent with the PD-L1-positive population. The safety profile was consistent with known effects of each study drug. Conclusion Combining atezolizumab with paclitaxel did not improve PFS or OS versus paclitaxel alone. ClinicalTrials.gov NCT03125902.
Published: 2021

8. PLA2G6 variants associated with the number of affected alleles in Parkinson's disease in Japan

Author: Kazuyuki Noda, Yuanzhe Li, Takanobu Takei, Hiroyo Yoshino, Hisamasa Imai, Ryoichi Kurisaki, T. Yamashita, Masahiko Tomiyama, Takao Hashimoto, Shigeru Matsuzaki, Fumikazu Kojima, Yoshio Tsuboi, Fusako Yokochi, Naohisa Ueda, Kenya Nishioka, Manabu Funayama, Katsuo Kimura, Kenichi Kashihara, Yuichiro, Morikazu Shibasaki, Shinji Ohara, Shinsuke Fujioka, Nobuya Fujita, Nobuhiro Dougu, Tomoyo Shimada, Hitoshi Yamada, Fumiaki Tanaka, Chizu Wada, Kensuke Daida, Yujiro Higuchi, Yuji Nakatsuji, Yoshinori Hirata, Takenori Uozumi, Nobutaka Hattori, Kazuma Sugie, Nobuyuki Eura, Yasushi Shimo, Chieko Suzuki, and Ryoichi Okiyama
Subjects: 0301 basic medicine, Adult, Male, Aging, Heterozygote, Parkinson's disease, Disease, Compound heterozygosity, Cohort Studies, Group VI Phospholipases A2, 03 medical and health sciences, symbols.namesake, Exon, 0302 clinical medicine, Gene Frequency, Japan, medicine, Humans, Genetic Predisposition to Disease, Allele, Age of Onset, Allele frequency, Genetic Association Studies, Aged, Sanger sequencing, Genetics, business.industry, General Neuroscience, Homozygote, Genetic Variation, Parkinson Disease, Middle Aged, medicine.disease, 030104 developmental biology, Cohort, symbols, Female, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Developmental Biology
Abstract: This study aimed to evaluate genotype-phenotype correlations of Parkinson’s disease (PD) patients with phospholipase A2 group V (PLA2G6) variants. We analyzed the DNA of 798 patients with PD, including 78 PD patients reported previously, and 336 in-house controls. We screened the exons and exon-intron boundaries of PLA2G6 using the Ion Torrent system and Sanger method. We identified 21 patients with 18 rare variants, such that 1, 9, and 11 patients were homozygous, heterozygous, and compound heterozygous, respectively, with respect to PLA2G6 variants. The allele frequency was approximately equal between patients with familial PD and those with sporadic PD. The PLA2G6 variants detected frequently were identified in the early-onset sporadic PD group. Patients who were homozygous for a variant showed more severe symptoms than those who were heterozygous for the variant. The most common variant was p.R635Q in our cohort, which was considered a risk variant for PD. Thus, the variants of PLA2G6 may play a role in familial PD and early-onset sporadic PD.
Published: 2020

9. Impact of Anode-side Defect Generation on Inter-Level TDDB Degradation in Cu/Low-k Damascene Structures

Author: H. Aono, H. Tsuchiya, T. Yamashita., Naohito Suzumura, and K. Omori
Subjects: 010302 applied physics, Materials science, Dielectric strength, business.industry, Copper interconnect, Time-dependent gate oxide breakdown, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Anode, Reliability (semiconductor), Etching (microfabrication), Electric field, 0103 physical sciences, Degradation (geology), Optoelectronics, 0210 nano-technology, business
Abstract: We investigated the inter-level time-dependent dielectric breakdown (VTDDB) degradation mechanisms in Cu/low-k damascene structures. Considering the dependence of VTDDB reliability and ILD film properties on the post etching treatment (PET) condition, it was found that defect generation near the anode-side interface impacts the VTDDB lifetime and that the absolute value of the lifetime could be improved by reducing the number of Si-H bonds near the anode side. On the other hand, the electric field acceleration factor is independent of the anode-side defects, which is discussed based on the "Impact Damage model." Furthermore, we demonstrated experimentally the relationship between the intra-level TDDB (LTDDB) and the VTDDB failure mechanisms.
Published: 2020

10. Exploring the versatility of double-sided fabrication of intrinsic Josephson junctions

Author: H.B. Wang, T. Hatano, S. Urayama, S.M. Kim, K. Inomata, Y. Takano, M. Nagao, Muller, P., A. Ishii, P.H. Wu, Arisawa, S., M. Tachiki, and T. Yamashita
Subjects: Integrated circuit fabrication -- Methods, Terahertz radiation -- Analysis, Josephson junction -- Design and construction, Integrated circuit fabrication, Business, Electronics, Electronics and electrical industries
Abstract: Various types of intrinsic Josephson junctions (IJJs) are fabricated using a double-sided process from BSCOO-2212 single crystals. The potential applications of IJJs as high frequency detectors or generators at terahertz region are demonstrated.
Published: 2005

11. Characterization of stacking faults with emission wavelengths of over 500 nm formed in 4H-SiC epitaxial films

Author: Hiroshi Osawa, Kazutoshi Kojima, Kenji Momose, Tomohisa Kato, Shohei Hayashi, Hajime Okumura, Junji Senzaki, T. Naijo, and T. Yamashita
Subjects: 010302 applied physics, Photoluminescence, Materials science, business.industry, Stacking, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Epitaxy, 01 natural sciences, Inorganic Chemistry, Crystallography, Wavelength, Transmission electron microscopy, 0103 physical sciences, Scanning transmission electron microscopy, Materials Chemistry, Optoelectronics, Partial dislocations, 0210 nano-technology, business, Spectroscopy
Abstract: Three types of unidentified stacking faults with emission wavelengths of over 500 nm were confirmed in 4H-SiC epitaxial films and characterized using grazing incident X-ray topography, transmission electron microscopy, and high-resolution scanning transmission electron microscopy. Photoluminescence spectroscopy measurements revealed that the SFs had emissions at around 550, 530, and 520 nm. Characterization indicated that the SFs included one Frank partial dislocation and several Shockley partial dislocations, although the determined stacking sequences of the SFs mainly consisted of the basic units of the 3C-structure. It was clarified that the SFs originated from narrow SFs with the same stacking sequence in the substrates.
Published: 2017

12. Poster Session 1The imaging examination and quality assessmentP185Why did the normal values of the left and right atrial volumes increase in the recent chamber quantification guidelines update?P186Atrial electromechanical delay, Left Atrial mechanical functions and longitudinal left ventricular strain in pre-diabetic patientsP187A web-based platform for e-training in echocardiographyP188Righ atrial size as a marker of success in electrical cardioversion in patients with persistent atrial fibrillationP189Echocardiographic assessment of left atrial dimensions and function in a healthy populationP190Impact of carotid artery revascularization on the cognitive and functional outcome and cerebral flow on TCD and brain MRI in patients with symptomatic carotid artery stenosis: a preliminary reportP191Aortic elasticity is impaired in hypereosinophilic syndromeP192Disturbed intracardiac flow transit prognosticates early decompensation in dilated cardiomyopathyP193Ultrasound guided treatment in acute heart failureP194Determinants of impaired global longitudinal function in middle-aged subjects free of cardiovascular diseaseP195Left ventricular remodeling in asymptomatic heart failure: classification and prognostic evaluationP196Restricted displacement of lateral right ventricular wall: a physiopathological explanation of geometrical and functional cardiac changes after cardiac surgeryP197A novel method to image intracardiac flow stagnation for the risk stratification for thrombosisP198Magnetic resonance imaging of anomalous origin of the left coronary artery from the pulmonary artery in children older than 4 monthsP199Coronary flow reserve is improved by LDL apheresis in patients with familial hypercholesterolemia and chronic ischemic heart diseaseP200 High velocities in the proximal part of the coronary arteries during routine echocardiography can predict nearest prognosisP201Recovery potential of the right ventricular function in the setting of a first STEMI treated by primary PCI: an echocardiographic studyP202Severe aortic stenosis patients with preserved ejection fraction according to flow and gradient classification: prevalence and outcomesP203Is basal left ventricular ejection time able to predict the severity of aortic stenosis in patients with depressed ejection fraction?P204Acceleration time in aortic stenosis: a new echocardiographic diagnostic parameterP205Application of novel Doppler indices of stenosis severity in the assessment of rheumatic mitral stenosis beyond conventional valve area and transvalvular gradientsP206Comparison of conventional echo score in patients with symptomatic rheumatic mitral stenosis: transesophageal echocardiography versus transthoracic echocardiographyP207Speckle-tracking echocardiography in evaluation early left ventricular systolic dysfunction in asymptomatic aortic regurgitation patients with good left ventricular ejection fractionP208Expansible aortic ring annuloplasty: mid-term results of aortic valve repairP209Papillary muscle dysfunction: insights into mitral valve prolapse using speckle tracking imaging

Author: L. Ring, Z. Hlubocka, V. Mizariene, YH. Park, A. Chong, D. Ruiz Fernandez, AS. Lazaro Mendes, JM. Monteagudo Ruiz, M. Stoian, A. Zagatina, E. Pasanisi, AJR Jurko, H. Nishikawa, A. Garcia Martin, I. Fabiani, I. Ceponiene, J. Oehman, T. Uejima, A. Nemes, R. Badacz, R W J Van Grootel, C. Doering, R. Conte, TAMER Moustafa, K. Kebed, E. Kruse, K. Addetia, B. Ciszek, M. Thykattil, B. Guile, RM. Lang, V. Mor-Avi, RAGAB Mahfouz, AHMED Elzayat, MOHAMD Goda, MARWA Gad, F. Sansone, F. Napoli, A. Tonacci, M. Raciti, P. Landi, A. Grande, L. Ait-Ali, K. Sveric, U. Richter, RH. Strasser, C. Wunderlich, ME. Menting, JS. Mcghie, M. Strachinaru, WB. Vletter, ML. Geleijnse, JW. Roos-Hesselink, AE. Van Den Bosch, A. Kablak-Ziembicka, M. Urbanczyk-Zawadzka, RP. Banys, P. Musialek, P. Pieniazek, S. Mleczko, K. Zmudka, T. Przewlocki, I. Marton, P. Domsik, A. Kalapos, E. Posfai, S. Modok, Z. Borbenyi, T. Forster, L. Takahashi, H. Semba, H. Sawada, T. Yamashita, R. Jurkevicius, J. Petkeviciene, O. Gustiene, E. Tamuleviciute-Prasciene, J. Motiejunaite, R. Slapikas, NR. Pugliese, S. La Carrubba, F. Antonini Canterin, P. Colonna, P. Caso, F. Benedetto, R. Citro, S. Carerj, V. Di Bello, JL. Moya Mur, C. Lazaro Rivera, LM. Rincon Diaz, J. Miguelena Hycka, A. Garcia Lledo, JJ. Jimenez Nacher, C. Fernandez-Golfin, J. Rodriguez-Roda, JL. Zamorano, A. Jurko, T. Jurko, J. Mistinova-Polakova, F. Sbrana, C. Petersen, F. Bigazzi, B. Dal Pino, M. Coceani, A. Ripoli, M. Pianelli, R. Luciani, T. Sampietro, N. Zhuravskaya, Y. Vareldzhyan, M. Kamenskikh, D. Shmatov, D. Zamfir, A. Vijiiac, D. Pitic, G. Tamasescu, S. Onciul, R. Onut, C. Stefan, M. Dorobantu, A. Gonzalez-Gomez, C. Izurieta, A. Marco, GL. Alonso Salinas, R. Hinojar Baydes, E. Casas Rojo, AR. Ferreira, J. Moura Ferreira, L. Leite, AP. Oliveira, N. Ribeiro, AJ. Barbosa, R. Mata Martins, D. Ramos, M. Pego, S. Gamaza Chulian, E. Diaz Retamino, S. Camacho Freire, A. Gutierrez Barrios, J. Oneto Otero, M. Bansal, HK. Grewal, RR. Kasliwal, S. Wahi, SH. Lee, DS. Lee, JM. Hwang, JS. Kim, JH. Kim, KJ. Chun, M. Bieseviciene, R. Verseckaite, R. Jonkaitiene, J. Janenaite, G. Dostalova, J. Hlubocky, R. Novotny, V. Vondracek, J. Lindner, A. Linhart, and NK. Preston
Subjects: Pediatrics, medicine.medical_specialty, business.industry, medicine, Follow up studies, Radiology, Nuclear Medicine and imaging, Regression analysis, General Medicine, Longitudinal function, Disease, Cardiology and Cardiovascular Medicine, business, Cohort study
Published: 2016

13. On a connectivity matrix formula for tensegrity prism plates

Author: T. Yamashita, Kenji Nagase, and N. Kawabata
Subjects: Engineering, business.industry, Force equilibrium, Mechanical Engineering, 02 engineering and technology, Structural engineering, Computer Science::Computational Geometry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Stress (mechanics), Matrix (mathematics), 020303 mechanical engineering & transports, 0203 mechanical engineering, Buckling, Mechanics of Materials, Simple (abstract algebra), Tensegrity, Mathematics::Metric Geometry, General Materials Science, Node (circuits), Prism, 0210 nano-technology, business, Civil and Structural Engineering
Abstract: This paper considers tensegrity structures constructed from repetition of simple fundamental units. The tensegrity prism is chosen as a fundamental unit, which allows us to build plates, columns, towers, and their variations. The connectivity matrix plays a central role in analysis and design of tensegrity structures. This paper provides a systematic way to construct connectivity matrices for tensegrity structures constructed from repetition of tensegrity prisms. The number of units and node locations (shape) can be chosen arbitrarily. As an application of the connectivity matrix, a minimal-mass design subjected to force equilibrium (force balance) and yield and buckling stress constraints is shown.
Published: 2016

14. A novel single-ended readout depth-of-interaction PET detector fabricated using sub-surface laser engraving

Author: Hiroshi Uchida, Toshiaki Sakai, T. Yamashita, K Hakamata, K. Shimizu, and H Yamauchi
Subjects: Photomultiplier, Materials science, Light, Surface Properties, Bar (music), Physics::Medical Physics, Scintillator, 01 natural sciences, Lyso, 030218 nuclear medicine & medical imaging, Crystal, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Optics, 0103 physical sciences, Animals, Humans, Radiology, Nuclear Medicine and imaging, Radiological and Ultrasound Technology, 010308 nuclear & particles physics, business.industry, Laser engraving, Lasers, Detector, Positron-Emission Tomography, Scintillation Counting, business, Single crystal
Abstract: We propose a novel scintillation detector design for positron emission tomography (PET), which has depth of interaction (DOI) capability and uses a single-ended readout scheme. The DOI detector contains a pair of crystal bars segmented using sub-surface laser engraving (SSLE). The two crystal bars are optically coupled to each other at their top segments and are coupled to two photo-sensors at their bottom segments. Initially, we evaluated the performance of different designs of single crystal bars coupled to photomultiplier tubes at both ends. We found that segmentation by SSLE results in superior performance compared to the conventional method. As the next step, we constructed a crystal unit composed of a 3 × 3 × 20 mm3 crystal bar pair, with each bar containing four layers segmented using the SSLE. We measured the DOI performance by changing the optical conditions for the crystal unit. Based on the experimental results, we then assessed the detector performance in terms of the DOI capability by evaluating the position error, energy resolution, and light collection efficiency for various crystal unit designs with different bar sizes and a different number of layers (four to seven layers). DOI encoding with small position error was achieved for crystal units composed of a 3 × 3 × 20 mm3 LYSO bar pair having up to seven layers, and with those composed of a 2 × 2 × 20 mm3 LYSO bar pair having up to six layers. The energy resolution of the segment in the seven-layer 3 × 3 × 20 mm3 crystal bar pair was 9.3%–15.5% for 662 keV gamma-rays, where the segments closer to the photo-sensors provided better energy resolution. SSLE provides high geometrical accuracy at low production cost due to the simplicity of the crystal assembly. Therefore, the proposed DOI detector is expected to be an attractive choice for practical small-bore PET systems dedicated to imaging of the brain, breast, and small animals.
Published: 2016

15. Radiation Tolerance of Aluminum Microwave Kinetic Inductance Detector

Author: Shibo Shu, T. Yamashita, Masato Naruse, Takashi Noguchi, Shigeyuki Sekiguchi, Masashi Hazumi, Masakazu Sekine, Agnes Dominjon, Kenichi Karatsu, N. Oka, Tomotake Matsumura, Tom Nitta, Yasuhiro Yamada, Yutaro Sekimoto, K. Mizukami, T. Funaki, T. Fujino, Hirokazu Ishino, F. Irie, and Y. Kida
Subjects: Physics, Proton, Physics::Instrumentation and Detectors, business.industry, Microwave kinetic inductance detectors, Astrophysics::Instrumentation and Methods for Astrophysics, LiteBIRD, Substrate (electronics), Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, Radiation tolerance, Resonator, Responsivity, Optics, Absorbed dose, 0103 physical sciences, General Materials Science, Irradiation, Satellite mission, 010306 general physics, business, 010303 astronomy & astrophysics, Microwave, Beam (structure)
Abstract: 著者人数: 20名, Accepted: 2016-01-21, 資料番号: SA1160044000
Published: 2016

16. Acute Multiple Cerebral Infarction in a Patient with an Accessory Mitral Valve

Author: Ikuo Misumi, Asako Nagao, Toshio Okazaki, T. Yamashita, Yumi Honda, Katsuya Iwamoto, Tsuyoshi Honda, Hidetsugu Ueyama, Masatoshi Ishizaki, Ryoichi Kurisaki, Masanobu Ishii, Yasushi Maeda, and Akiko Fujimoto
Subjects: medicine.medical_specialty, Case Report, 030204 cardiovascular system & hematology, Doppler echocardiography, Ventricular Outflow Obstruction, Diagnosis, Differential, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Internal medicine, Mitral valve, Internal Medicine, medicine, Ventricular outflow tract, left ventricular outflow obstruction, Humans, cardiovascular diseases, Postoperative Period, Aged, 80 and over, medicine.diagnostic_test, business.industry, Cerebral infarction, Left ventricular outflow obstruction, Magnetic resonance imaging, General Medicine, Cerebral Infarction, medicine.disease, Magnetic Resonance Imaging, Surgery, accessory mitral valve, medicine.anatomical_structure, Hemiparesis, Echocardiography, Orthopedic surgery, Cardiology, cardiovascular system, Mitral Valve, Female, medicine.symptom, business, Femoral Fractures, 030217 neurology & neurosurgery
Abstract: A 96-year-old woman developed hemiparesis 2 weeks after orthopedic surgery. Magnetic resonance imaging revealed multiple cerebral infarctions in the bilateral hemisphere. Transthoracic echocardiography revealed a mobile structure attached to the anterior mitral leaflet that protruded toward the left ventricular outflow tract. The structure was identified as an accessory mitral valve. Doppler echocardiography showed that there was no significant left ventricular outflow obstruction. This is a rare case of a silent accessory mitral valve that was detected after multiple cerebral infarctions.
Published: 2017

17. Novel Integration Scheme of Replacement Metal Gate Module using Pre-Metal Dielectrics with High Gap-Fill Capability and Chemical Reaction Based H2O2 Cure

Author: T. Yamaguchi, M. Inoue, A. Yoshitomi, T. Hayashi, M. Kadoshima, S. Kato, S. Muranaka, T. Maruyama, T. Yamashita, and M. Matsuura
Subjects: Metal, Materials science, business.industry, visual_art, visual_art.visual_art_medium, Optoelectronics, Dielectric, Metal gate, business, Chemical reaction
Published: 2018

18. Efficiency enhancement of PV cell emulating system in connection mode

Author: I. Mizoguchi, Muneaki Ishida, Naoki Yamamura, T. Yamashita, Nguyen Thuy Nga, and Vu Minh Phap
Subjects: Small wind turbine, Power conditioner, business.industry, Computer science, Photovoltaic system, Electrical engineering, business, Series and parallel circuits, Turbine, Solar power, Power (physics), Voltage
Abstract: The grid-tied solar power systems are rapidly developing in many countries. The working efficiency of the power conditioner system (PCS) in the grid-tied solar power system is limited because the power supply from solar panel depends on the climate condition. We proposed a novel technical design in the previous research to connect the small scale wind turbine with the PCS of the grid-tied solar power system by emulating technical characteristics of the PV in series connection mode. Therefore, the utilization rate of the PCS was enhanced. However, this enhanced operating efficiency of the PCS is not good in changing solar irradiation condition because the maximum input voltage of the PCS is restricted and the output voltage of the PV alters slightly. Thus, we introduce a technical method of efficiency improvement for the photovoltaic (PV) cell emulating system in connection mode in this research.
Published: 2018

19. The LiteBIRD Satellite Mission: Sub-Kelvin Instrument

Author: A. Suzuki, P. A. R. Ade, Y. Akiba, D. Alonso, K. Arnold, J. Aumont, C. Baccigalupi, D. Barron, S. Basak, S. Beckman, J. Borrill, F. Boulanger, M. Bucher, E. Calabrese, Y. Chinone, S. Cho, B. Crill, A. Cukierman, D. W. Curtis, T. de Haan, M. Dobbs, A. Dominjon, T. Dotani, L. Duband, A. Ducout, J. Dunkley, J. M. Duval, T. Elleflot, H. K. Eriksen, J. Errard, J. Fischer, T. Fujino, T. Funaki, U. Fuskeland, K. Ganga, N. Goeckner-Wald, J. Grain, N. W. Halverson, T. Hamada, T. Hasebe, M. Hasegawa, K. Hattori, M. Hattori, L. Hayes, M. Hazumi, N. Hidehira, C. A. Hill, G. Hilton, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, M. Inoue, Y. Inoue, K. D. Irwin, H. Ishino, O. Jeong, H. Kanai, D. Kaneko, S. Kashima, N. Katayama, T. Kawasaki, S. A. Kernasovskiy, R. Keskitalo, A. Kibayashi, Y. Kida, K. Kimura, T. Kisner, K. Kohri, E. Komatsu, K. Komatsu, C. L. Kuo, N. A. Kurinsky, A. Kusaka, A. Lazarian, A. T. Lee, D. Li, E. Linder, B. Maffei, A. Mangilli, M. Maki, T. Matsumura, S. Matsuura, D. Meilhan, S. Mima, Y. Minami, K. Mitsuda, L. Montier, M. Nagai, T. Nagasaki, R. Nagata, M. Nakajima, S. Nakamura, T. Namikawa, M. Naruse, H. Nishino, T. Nitta, T. Noguchi, H. Ogawa, S. Oguri, N. Okada, A. Okamoto, T. Okamura, C. Otani, G. Patanchon, G. Pisano, G. Rebeiz, M. Remazeilles, P. L. Richards, S. Sakai, Y. Sakurai, Y. Sato, N. Sato, M. Sawada, Y. Segawa, Y. Sekimoto, U. Seljak, B. D. Sherwin, T. Shimizu, K. Shinozaki, R. Stompor, H. Sugai, H. Sugita, J. Suzuki, O. Tajima, S. Takada, R. Takaku, S. Takakura, S. Takatori, D. Tanabe, E. Taylor, K. L. Thompson, B. Thorne, T. Tomaru, T. Tomida, N. Tomita, M. Tristram, C. Tucker, P. Turin, M. Tsujimoto, S. Uozumi, S. Utsunomiya, Y. Uzawa, F. Vansyngel, I. K. Wehus, B. Westbrook, M. Willer, N. Whitehorn, Y. Yamada, R. Yamamoto, N. Yamasaki, T. Yamashita, M. Yoshida, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)
Subjects: Cosmic microwave background, FOS: Physical sciences, cosmic background radiation: polarization, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Radio spectrum, law.invention, Antenna array, Telescope, Optics, bolometer, Settore FIS/05 - Astronomia e Astrofisica, law, Polarization, 0103 physical sciences, B-mode, Inflation, Satellite, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, activity report, detector: design, Physics, 010308 nuclear & particles physics, business.industry, Gravitational wave, Detector, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Astrophysics - Astrophysics of Galaxies, Atomic and Molecular Physics, and Optics, cryogenics, Astrophysics of Galaxies (astro-ph.GA), electronics: readout, interference: quantum, Transition edge sensor, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], business, cosmic background radiation: anisotropy
Abstract: 著者人数: 153名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 堂谷, 忠靖; 羽澄, 昌史; 今田, 大皓; 満田, 和久; 坂井, 真一郎; Tomida, T.; 辻本, 匡弘; Yamamoto, R.; 山崎, 典子）, Accepted: 2018-04-30, 資料番号: SA1180210000
Published: 2018

20. P.337Dystrophin restoration by exon 53 skipping in patients with Duchenne muscular dystrophy after viltolarsen treatment: phase 2 study update

Author: V. Rao, Amy Harper, Eric P. Hoffman, J. Mah, Craig M. Zaidman, Paula R. Clemens, T. Yamashita, Lauren P. Morgenroth, and Anne M. Connolly
Subjects: Oncology, medicine.medical_specialty, business.industry, Duchenne muscular dystrophy, Phases of clinical research, medicine.disease, Exon, Neurology, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, In patient, Neurology (clinical), business, Genetics (clinical)
Published: 2019

21. Alpelisib (ALP) + fulvestrant (FUL) for patients with hormone receptor–positive (HR+), HER2− advanced breast cancer (ABC): Management and time course of key adverse events of special interest (AESIs) in SOLAR-1

Author: M. Campone, Dejan Juric, Hope S. Rugo, M. Miller, Eva Ciruelos, Ines Lorenzo, S. Loibl, Salomon M. Stemmer, Ingrid A. Mayer, J. Cruz Jurado, T. Yamashita, David Mills, H. Iwata, Pierfranco Conte, I. Toledano, Fabrice Andre, H. Cerda, and C. Wilke
Subjects: 0301 basic medicine, Plasma glucose, medicine.medical_specialty, education.field_of_study, business.industry, Advanced breast, Population, Endocrine therapy, Stock options, ANTIPROPULSIVES, Hematology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Family medicine, Time course, Medicine, Time to onset, business, education
Abstract: Background PIK3CA mutations occur in ≈ 40% of HR+/HER2− breast cancers. In the phase III SOLAR-1 study (NCT02437318), ALP (PI3Kα inhibitor) + FUL significantly prolonged progression-free survival vs placebo (PBO) + FUL in patients (pts) with HR+/HER2− ABC, prior endocrine therapy, and PIK3CA mutations (HR 0.65; P Methods Pts received ALP + FUL (n=284) or PBO + FUL (n=287). Safety was assessed per CTCAE v4.03 and regardless of PIK3CA mutation status. We evaluated time to onset and management of key AESIs in patients receiving ALP. Results The median ALP treatment exposure was 5.5mo. As previously reported, the most common any-grade AESIs were hyperglycemia, diarrhea, and rash (Table). Rates of ALP discontinuation and median times to onset and improvement are presented in the table. Supportive medication was frequently used to manage hyperglycemia, diarrhea, and rash. In pts with anti-rash medication initiated prior to onset of rash (n=86), 60 (69.8%) received antihistamines. Use of anti-rash medication prior to onset of rash was associated with decreased frequency of rash (26.7% vs 53.9% in the overall population) and decreased reported grade (grade 3, 11.6% vs 20.1%). During the study, the implementation of more detailed AE management guidelines decreased treatment discontinuation due to any-grade AEs (29.2% vs 20.7%) and grade ≥ 3 events (18.1% vs 7.9%) between the first 50% of pts randomized and the last 50% of patients randomized.Table324PTableHyperglycemiaDiarrhea0010Rashn=284Pts with any-grade event, n (%)187 (65.8)164 (57.7)153 (53.9)-ALP discontinuation due to event, n (%)19 (10.2)8 (4.9)12 (7.8)-Received supportive medication, n (%)163 (87.2)104 (63.4)134 (87.6)-Most-common supportive medication for any-grade event, n (%)Metformin, 142 (87.1)Antipropulsives, 69 (66.3)Steroids, 113 (84.3)b,cPts with ≥ grade-3 event, n (%)110 (38.7)d19 (6.7)28 (9.9)e-Time to onset, median (range), days15 (5-395)d139 (10-470)13 (9-571)e-Time to improvement by≥1 grade, median (95% CI), days6 (4-7)d,f18 (9-45)11 (8-NE)eaBased on preferred term.bNote that this is for pts who already had developed rash, which is different from pts who received medication before the onset of rash.cIncludes both topical and systemic.dBased on fasting plasma glucose values.eBased on single preferred term.fRange. Conclusions Adverse events associatated with ALP were manageable, improved with appropriate intervention (medication and/or ALP dose interruptions/modifications), and were generally reversible upon treatment discontinuation. Use of anti-rash medication prior to rash onset reduced the frequency and grade of rash. Clinical trial identification NCT02437318. Editorial acknowledgement Tara Wabbersen of MediTech Media, LLC funded by Novartis. Legal entity responsible for the study Novartis. Funding Novartis Pharmaceuticals Corp. Disclosure H.S. Rugo: Research grant / Funding (institution), Travel / Accommodation / Expenses: Pfizer Inc.; Research grant / Funding (institution), Travel / Accommodation / Expenses: Merck Sharp & Dohme Corp.; Research grant / Funding (institution): Novartis International AG; Research grant / Funding (institution), Travel / Accommodation / Expenses: Eli Lilly and Company; Research grant / Funding (institution): Genentech, Inc.; Research grant / Funding (institution): Oklahoma Blood Institute; Research grant / Funding (institution): Odonate Therapeutics, Inc.; Research grant / Funding (institution): Daiichi Sankyo Company, Limited; Travel / Accommodation / Expenses: Mylan N.V.; Travel / Accommodation / Expenses: Amgen Inc.; Travel / Accommodation / Expenses: Puma Biotechnology, Inc. F. Andre: Research grant / Funding (institution): Novartis International AG; Research grant / Funding (institution): AstraZeneca; Research grant / Funding (institution): Pfizer Inc.; Research grant / Funding (institution): Eli Lilly and Company; Research grant / Funding (institution): F. Hoffmann-La Roche Ltd. T. Yamashita: Honoraria (self), Research grant / Funding (institution): Chugai Pharma USA, Inc; Honoraria (self): Eisai Inc.; Honoraria (self): Novartis International AG; Honoraria (self): Taiho Oncology, Inc.; Honoraria (self), Research grant / Funding (institution): Nippon Kayaku Co.,Ltd.; Honoraria (self): AstraZeneca; Honoraria (self), Research grant / Funding (institution): Kyowa Hakko Kirin Co., Ltd.; Honoraria (self): Pfizer Inc. J. Cruz Jurado: Honoraria (self): Novartis International AG; Honoraria (self): Genentech, Inc.; Honoraria (self): Elsai; Honoraria (self): Ipsen; Honoraria (self): EMD Serono. D. Juric: Honoraria (self): Novartis International AG; Honoraria (self): Genentech, Inc.; Honoraria (self): Eisai Inc.; Honoraria (self): Ipsen Pharma; Honoraria (self): EMD Serono, Inc. I. Mayer: Honoraria (self), Research grant / Funding (institution): Novarts International AG; Research grant / Funding (institution): Genentech, Inc.; Research grant / Funding (institution): Pfizer, Inc.; Honoraria (self): Eli Lilly and Company; Honoraria (self): AstraZeneca; Honoraria (self): GlaxoSmithKline plc.; Honoraria (self): MacroGenics, Inc. E.M. Ciruelos: Honoraria (self), Advisory / Consultancy, Speaker Bureau / Expert testimony: Novartis International AG; Honoraria (self), Advisory / Consultancy, Speaker Bureau / Expert testimony: Eli Lilly and Company; Honoraria (self), Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: F. Hoffmann-La Roche Ltd; Honoraria (self), Advisory / Consultancy, Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: Pfizer Inc. H. Iwata: Honoraria (self), Research grant / Funding (institution): Novartis International AG; Honoraria (self): F. Hoffmann-La Roche via Chugai; Honoraria (self): AstraZeneca; Honoraria (self): Pfizer, Inc.; Honoraria (self): Eli Lilly and Company; Honoraria (self): Daiichi Sankyo Company, Ltd. P.F. Conte: Speaker Bureau / Expert testimony, Research grant / Funding (institution), Travel / Accommodation / Expenses: Novartis International AG; Speaker Bureau / Expert testimony, Research grant / Funding (institution): F. Hoffmann-La Roche Ltd; Speaker Bureau / Expert testimony: Genentech, Inc.; Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: AstraZeneca; Research grant / Funding (institution): EMD Serono, Inc.; Travel / Accommodation / Expenses: Celgene Corporation. M. Campone: Research grant / Funding (institution): Novartis International AG; Honoraria (self), Research grant / Funding (institution): F. Hoffmann-La Roche Ltd; Honoraria (self): AstraZeneca; Honoraria (self): Pfizer, Inc.; Honoraria (institution): Servier Laboratories; Honoraria (institution): Sanofy; Honoraria (institution): Accord; Research grant / Funding (institution): Tessaro. C. Wilke: Shareholder / Stockholder / Stock options, Full / Part-time employment: Novartis. D. Mills: Shareholder / Stockholder / Stock options, Full / Part-time employment: Novartis International AG. M. Miller: Shareholder / Stockholder / Stock options, Full / Part-time employment: Novartis. S. Loibl: Honoraria (institution): Novartis International AG; Honoraria (institution): Pfizer, Inc.; Honoraria (institution): Celgene Corporation; Honoraria (institution): Amgen; Honoraria (institution): F. Hoffmann-La Roche Ltd; Honoraria (institution): AstraZeneca; Honoraria (institution): Abbvie; Honoraria (institution): Eli Lilly and Company; Honoraria (institution): Daiichi Sankyo Company, Ltd; Honoraria (institution): Eirgenix. All other authors have declared no conflicts of interest.
Published: 2019

22. First-in-Human Phase I Study of a Non-Woven Fabric Bioabsorbable Spacer Combined with Particle Therapy Against Abdominal or Pelvic Sarcomas

Author: Kenji Yoshida, Shohei Komatsu, T. Yamashita, Tomoaki Okimoto, Takumi Fukumoto, Daisuke Miyawaki, Hiroaki Akasaka, Y. Demizu, T. Wang, and Ryohei Sasaki
Subjects: Cancer Research, Radiation, Particle therapy, Oncology, business.industry, Woven fabric, medicine.medical_treatment, Medicine, Radiology, Nuclear Medicine and imaging, First in human, business, Biomedical engineering, Phase i study
Published: 2019

23. Abstract OT1-03-02: Evaluation of the use of oral care to prevent oral mucositis in estrogen receptor positive metastatic breast cancer patients treated with everolimus: Phase III randomized control trial

Author: Hirofumi Mukai, Y Ohta, Norio Hayashi, K-i Watanabe, Kosuke Kashiwabara, M Umeda, T Yamashita, M Naito, and Naoki Niikura
Subjects: Cancer Research, medicine.medical_specialty, Everolimus, business.industry, Oral Surgeon, medicine.disease, Metastatic breast cancer, Surgery, law.invention, chemistry.chemical_compound, Breast cancer, Oncology, Exemestane, chemistry, Randomized controlled trial, law, Internal medicine, Mucositis, medicine, Clinical endpoint, business, medicine.drug
Abstract: Background: In patients with estrogen receptor (ER)-positive advanced breast cancer, everolimus plus exemestane prolongs progression-free survival compared to exemestane monotherapy. However, as an adverse event from everolimus, oral mucositis (all grades) has been reported in 58% of all patients and 81% of Asian patients. Although no established prevention method is available, a previous study reported that professional oral care might prevent oral mucositis, and dentists have hypothesized that such care can reduce the occurrence of oral mucositis induced by everolimus. To evaluate this hypothesis, we compare the incidence of oral mucositis with and without professional oral care. Method: This is a randomized, multi-center, open-label, phase III study to evaluate the efficacy of professional oral care in preventing oral mucositis induced by everolimus in postmenopausal ER-positive metastatic breast cancer (MBC). Patients will be randomized into professional oral care and control groups (1:1 ratio). All patients will receive everolimus (10 mg daily) with exemestane (25 mg daily) and will continue everolimus until disease progression. Before the initiation of everolimus, instruction on a professional brushing method will be provided to both groups by specialists. In the professional oral care group, patients will receive teeth surface cleaning, scaling, and tongue cleaning before starting everolimus, and will continue to receive professional oral care weekly from oral surgeons throughout the 8 week treatment. In the control group, patients will brush their own teeth and gargle with 0.9% sodium chloride solution or water. The primary endpoint is the incidence of all grades of oral mucositis. The secondary endpoints are the incidence of over grade 2 and over 3 oral mucositis as determined by an oncologist and oral surgeons. The endpoints include onset and duration of oral mucositis. Major eligibility criteria include: 1) Postmenopausal women with ER positive MBC, and 2) No more than one prior chemotherapy treatment for MBC. Target accrual is 200 patients with a two-sided type I error rate of 5% and 80% power to detect 25% risk reduction. This study has just begun, and 5 of a planned 200 patients have been enrolled. (This study was registered with the UMIN 000016109). Citation Format: Niikura N, Ohta Y, Hayashi N, Naito M, Kashiwabara K, Watanabe K, Yamashita T, Mukai H, Umeda M. Evaluation of the use of oral care to prevent oral mucositis in estrogen receptor positive metastatic breast cancer patients treated with everolimus: Phase III randomized control trial. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr OT1-03-02.
Published: 2016

24. A Wide-Range Variable-Frequency Resonant Tunneling Diode Oscillator Based on a Novel MEMS Phase Shifter

Author: T. Yamashita, D. Nakano, M. Mori, and K. Maezawa
Subjects: Microelectromechanical systems, Range (particle radiation), Materials science, business.industry, Resonant-tunneling diode, Optoelectronics, business, Phase shift module, Variable (mathematics)
Published: 2017

25. FinFET Split-Gate MONOS for Embedded Flash in 16/14nm-node and Beyond

Author: S. Tsuda, Y. Kawashima, K. Sonoda, A. Yoshitomi, T. Mihara, S. Narumi, M. Inoue, S. Muranaka, T. Maruyama, T. Yamashita, Y. Yamaguchi, and D. Hisamoto
Subjects: Flash (photography), Materials science, business.industry, Node (networking), Electrical engineering, business
Published: 2017

26. Comprehensive Analysis of Low-frequency Noise Variability Components in Bulk and FDSOI (SOTB) MOSFETs

Author: K. Maekawa, H. Makiyama, Y. Yamamoto, T. Hasegawa, S. Okanishi, K. Sonoda, H. Shinkawata, T. Yamashita, S. Kamohara, and Y. Yamaguchi
Subjects: Materials science, business.industry, Infrasound, Optoelectronics, business
Published: 2017

27. P679A potent vasoconstrictor Kisspeptin-10 accelerates atherosclerosis: amelioration by its receptor GPR54 antagonist

Author: Hatsue Ishibashi-Ueda, T. Hirano, K. Sato, Shinji Koba, T. Yamashita, T. Watanabe, R. Shirai, Youichi Kobayashi, R. Watanabe, Taka-aki Matsuyama, and H. Yoshizawa
Subjects: Kisspeptin, business.industry, Antagonist, Medicine, Pharmacology, Cardiology and Cardiovascular Medicine, Receptor, business
Published: 2017

28. P5246Preoperative soleal vein diameter determined by ultrasonography is an independent predictor of deep vein thrombosis regardless of the type of major orthopedic surgery

Author: Daigo Nagahara, S. Nagoya, A. Teramoto, Satoshi Takahashi, Tetsuji Miura, Satoshi Yuda, K. Abe, K. Yasui, Y. Kawano, T. Yamashita, A. Okubo, C. Kobayashi, N. Yanagihara, and N. Oba
Subjects: medicine.medical_specialty, business.industry, Deep vein, Independent predictor, medicine.disease, Thrombosis, Surgery, medicine.anatomical_structure, Soleal vein, Orthopedic surgery, medicine, Radiology, Ultrasonography, Cardiology and Cardiovascular Medicine, business, Lower limbs venous ultrasonography
Published: 2017

29. Concept Study of Optical Configurations for High-Frequency Telescope for LiteBIRD

Author: D. W. Curtis, M. Nakajima, T. Funaki, R. Takaku, Yoshinori Uzawa, Carlo Baccigalupi, Johannes Hubmayr, U. Fuskeland, Theodore Kisner, S. Beckman, Anna Mangilli, Erminia Calabrese, Neil Goeckner-Wald, Uroš Seljak, M. Nagai, N. Katayama, Jonathan Aumont, Carole Tucker, Suguru Takada, Shin Utsunomiya, Kazunori Kohri, R. Nagata, Kam Arnold, M. Bucher, A. Dominjon, N. Sato, M. A. Dobbs, Shin-ichiro Sakai, Darcy Barron, Gene C. Hilton, H. K. Eriksen, Yasuhiro Yamada, Oliver Jeong, Aritoki Suzuki, Atsushi Okamoto, Tadayasu Dotani, T. Tomida, D. Meilhan, L. Duband, S. A. Kernasovskiy, S. Takakura, S. Takatori, R. Stompor, A. Ducout, B. Thorne, Eiichiro Komatsu, Hajime Sugai, Keisuke Shinozaki, N. Tomita, J. Fischer, Yuji Chinone, C. L. Kuo, L. Montier, Akito Kusaka, Toshiaki Iida, Aaron Lee, Yuki Inoue, Makoto Sawada, Ingunn Kathrine Wehus, L. Hayes, Mitsuhiro Yoshida, K. L. Thompson, H. Nishino, Mathieu Remazeilles, Tomotake Matsumura, Shugo Oguri, K. Komatsu, Reijo Keskitalo, T. Yamashita, T. Kawasaki, Takahiro Okamura, Masashi Hazumi, Osamu Tajima, Takayuki Tomaru, G. Patanchon, M. Tristram, Giampaolo Pisano, Hirokazu Ishino, Masato Naruse, Jun-ichi Suzuki, H. M. Cho, Paul Turin, Toshiya Namikawa, Yuki Sakurai, Y. Kida, Blake D. Sherwin, J. Grain, Chiko Otani, Noriko Y. Yamasaki, N. W. Halverson, Shuji Matsuura, S. Uozumi, Takashi Noguchi, T. Nagasaki, H. Imada, M. Willer, Y. Sato, M. Inoue, J. M. Duval, Bruno Maffei, Toshifumi Shimizu, Yuto Minami, F. Boulanger, Tucker Elleflot, Charles A. Hill, Benjamin Westbrook, Shogo Nakamura, Peter A. R. Ade, Kaori Hattori, Paul L. Richards, Alex Lazarian, Y. Segawa, Julian Borrill, Ryo Yamamoto, Kiyotomo Ichiki, M. Maki, Satoru Mima, D. Tanabe, Jo Dunkley, Kazuhisa Mitsuda, Soumen Basak, Gabriel M. Rebeiz, Tom Nitta, T. de Haan, T. Hamada, H. Kanai, K. Ganga, Hideo Ogawa, D. Kaneko, A. Cukierman, Nathan Whitehorn, Eric V. Linder, Masaya Hasegawa, Josquin Errard, Kimihiro Kimura, Hiroyuki Sugita, David Alonso, T. Hasebe, Kent D. Irwin, E. Taylor, Norio Okada, N. Hidehira, Shingo Kashima, A. Kibayashi, Noah Kurinsky, T. Fujino, Y. Akiba, Makoto Hattori, Dale Li, Masahiro Tsujimoto, Yutaro Sekimoto, F. Vansyngel, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), and Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA))
Subjects: Cosmic microwave background radiation, Inflation, Satellite, Telescope, Silicon, Cosmic microwave background, chemistry.chemical_element, engineering.material, 01 natural sciences, law.invention, 010309 optics, Optics, Settore FIS/05 - Astronomia e Astrofisica, Coating, law, 0103 physical sciences, General Materials Science, Sensitivity (control systems), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Physics, business.industry, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Lens (optics), chemistry, engineering, Reflection (physics), business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: 著者人数: 152名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 長谷部, 孝; 堂谷, 忠靖; 羽澄, 昌史; 今田, 大皓; 満田, 和久; 坂井, 真一郎; 関本, 裕太郎; Tomida, T.; 辻本, 匡弘; Yamamoto, R.; 山崎, 典子), Accepted: 2018-04-07, 資料番号: SA1180209000
Published: 2017

30. Effect of sodium-glucose co-transporter-2 inhibitors on impaired ventricular repolarization in people with Type 2 diabetes

Author: Toshiyuki Yano, A. Takada, Takayuki Miki, Tetsuji Miura, Akihito Tsuchida, Hirofumi Ohnishi, T Sato, Masaya Tanno, and T. Yamashita
Subjects: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Sodium, chemistry.chemical_element, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, QT interval, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Sodium-Glucose Transporter 2, Heart Rate, Internal medicine, Diabetes mellitus, Heart rate, Internal Medicine, Ventricular Dysfunction, Medicine, Humans, Hypoglycemic Agents, Sodium-Glucose Transporter 2 Inhibitors, Aged, Retrospective Studies, business.industry, Transporter, Middle Aged, medicine.disease, Blood pressure, Treatment Outcome, chemistry, Diabetes Mellitus, Type 2, Female, SGLT2 Inhibitor, business, Diabetic Angiopathies
Abstract: Aims To test the hypothesis that treatment with a sodium-glucose co-transporter-2 inhibitor would reverse ventricular repolarization heterogeneity, a predictor of cardiovascular mortality, in people with Type 2 diabetes. Methods We retrospectively analysed changes in indices of ventricular repolarization before and after treatment with a sodium-glucose co-transporter-2 inhibitor in 46 people with Type 2 diabetes. Results Sodium-glucose co-transporter-2 inhibitor treatment reduced HbA1c concentration [62±13 mmol/mol (7.7±1.2%] vs 59±16 mmol/mol (7.5±1.4%)], body weight (77.8±13.9 vs 74.7±12.5 kg) and systolic blood pressure (133±18 vs 126±12 mmHg) in the study participants. Heart rate and QTc interval were not changed by sodium-glucose co-transporter-2 inhibitor treatment, but QTc dispersion was significantly reduced (median, 48.8 vs 44.2 ms). Sodium-glucose co-transporter-2 inhibitor treatment reversed QTc dispersion more in participants who had larger QTc dispersion before the treatment. Changes in systolic blood pressure (Spearman's ρ= 0.319; P=0.031), but not in HbA1c concentration, were correlated with changes in QTc dispersion after SGLT2 inhibitor treatment. Conclusions The findings suggest that sodium-glucose co-transporter-2 inhibitor treatment reverses ventricular repolarization heterogeneity in people with Type 2 diabetes, independently of its effect on glycaemic control. The favourable effect on ventricular repolarization heterogeneity could be the mechanism by which empaglifozin reduced cardiovascular events in a recent study. This article is protected by copyright. All rights reserved.
Published: 2017

31. Fabrication of Finely Pitched LYSO Arrays Using Subsurface Laser Engraving Technique with Picosecond and Nanosecond Pulse Lasers

Author: Takahiro Moriya, T. Yamashita, Kenshi Fukumitsu, and Mitsuo Watanabe
Subjects: Nuclear and High Energy Physics, Materials science, business.industry, Laser engraving, Nanosecond, Scintillator, Laser, Lyso, Pulsed laser deposition, law.invention, X-ray laser, Optics, Nuclear Energy and Engineering, law, Picosecond, Optoelectronics, Electrical and Electronic Engineering, business
Abstract: We propose to adopt the subsurface laser engraving (SSLE) technique for efficient and precise fabrication of finely pitched scintillation crystal arrays. However, its application to thicker crystals is still challenging. It is difficult to focus the laser beam tightly at a point far from the crystal's surface because of the large refractive index of the scintillator. Therefore, a higher laser energy is needed to create microcracks at deep positions in the crystal. Because this would cause excessive damage to the scintillation crystal during laser scans, the process yield of SSLE is reduced. We found that this issue could be overcome by a novel SSLE technique using both picosecond (ps) and nanosecond (ns) pulse lasers. The experimental results indicated that the total laser energy required for creating microcrack walls in a LYSO crystal can be reduced compared to that of conventional SSLE using only a ns pulse laser. The SSLE technique using both ps and ns pulse lasers would enable the fabrication of finely pitched LYSO arrays with a higher process yield.
Published: 2014

32. Evaluating the prevalence of the expression of PD-L1 in NSCLC specimens with short-duration formalin fixation using IHC 22C3 pharmDx

Author: Keiichi Ota, T. Yamashita, T. Nakanishi, M. Yoshimi, H. Okabayashi, A. Fujita, T. Nakano, Y. Tao, T. Ueno, and S. Takata
Subjects: Oncology, medicine.medical_specialty, medicine.diagnostic_test, biology, business.industry, Immune checkpoint inhibitors, Hematology, Pembrolizumab, Bronchoscopy, Internal medicine, PD-L1, Biopsy, biology.protein, Medicine, Immunohistochemistry, Antibody, business, Companion diagnostic
Abstract: Background Immune checkpoint inhibitors mediated by PD-1 and PD-L1 are promising treatments for various tumors. The PD-L1 expression in tumor cells was found to be correlated with the likelihood of a response to PD-1- or PD-L1-targeted therapy in non-small cell lung cancer (NSCLC). For PD-L1 immunohistochemistry (IHC), 22C3 pharmDx is the only companion diagnostic assay that can identify NSCLC patients suitable for pembrolizumab treatment. Specimens are scored and divided into 3 categories ( Methods We screened consecutive NSCLC patients who underwent tumor biopsy by bronchoscopy between January 2017 and June 2018 at National Hospital Organization Fukuokahigashi Medical Center. In the present study, we only included 70 patients whose tumors were formalin-fixed for less than 6 h and whose PD-L1 expression had been evaluated by IHC with antibodies to human PD-L1 (22C3 pharmDx). Results The PD-L1 prevalence in patients with NSCLC in our hospital was 26 (37%) with TPS Conclusions The PD-L1 prevalence in specimens with short-duration formalin fixation was consistent with the results of the KEYNOTE-024 trial. We will present our conclusion regarding these results, including the characteristics of patients and the PD-L1 prevalence in specimens fixed for 12-72 h in our institution, from July 2018 onward. Legal entity responsible for the study National Hospital Organization Fukuokahigashi Medical Center. Funding JSPS KAKENHI JP18K15927. Disclosure All authors have declared no conflicts of interest.
Published: 2019

33. Observation of multilayer Shockley-type stacking fault formation during process of epitaxial growth on highly nitrogen-doped 4H-SiC substrate

Author: Kazuma Eto, Hiroshi Osawa, Tomohisa Kato, Hajime Okumura, Hiromasa Suo, and T. Yamashita
Subjects: 010302 applied physics, Materials science, Physics and Astronomy (miscellaneous), business.industry, General Engineering, Stacking, General Physics and Astronomy, Substrate (electronics), Chemical vapor deposition, Epitaxy, 01 natural sciences, Scientific method, 0103 physical sciences, Scanning transmission electron microscopy, Optoelectronics, business, Layer (electronics), Stacking fault
Abstract: We investigated the formation of double Shockley-type stacking fault (DSF) and other types of stacking fault (SF) during a process of epitaxial growth by chemical vapor deposition on a highly nitrogen-doped 4H-SiC substrate. By comparing the bulk substrate before epitaxial growth and the substrate after growth with an epitaxial layer, bar-shaped SFs turned out to have formed during the process of epitaxial growth on the highly nitrogen-doped substrate. These bar-shaped SFs were identified to be DSFs and triple Shockley-type stacking faults by scanning transmission electron microscopy.
Published: 2019

34. CKD-MBD II

Author: T. Fujii, S. Suzuki, M. Shinozaki, H. Tanaka, S. Bell, S. Cooper, C. Lomonte, P. Libutti, D. Chimienti, F. Casucci, A. Bruno, M. Antonelli, P. Lisi, L. Cocola, C. Basile, A. Negri, E. Del Valle, M. Zanchetta, J. Zanchetta, M. C. Di Vico, M. Ferraresi, A. Pia, E. Aroasio, S. Gonella, E. Mongilardi, R. Clari, I. Moro, G. B. Piccoli, E. Gonzalez-Parra, L. Rodriguez-Osorio, A. Ortiz-Arduan, C. de la Piedra, J. Egido, M. V. Perez Gomez, A. A. Tabikh, B. Afsar, A. Kirkpantur, Y. Imanishi, M. Yamagata, Y. Nagata, M. Ohara, T. Michigami, T. Yukimura, M. Inaba, B. Bieber, B. Robinson, L. Mariani, S. Jacobson, L. Frimat, J. Bommer, R. Pisoni, F. Tentori, P. Ciceri, F. Elli, D. Brancaccio, M. Cozzolino, M. Adamczak, A. Wiecek, P. Kuczera, S. Sezer, Z. Bal, E. Tutal, O. Kal, D. Yavuz, I. Y ld r m, B. Sayin, R. Ozelsancak, S. Ozkurt, S. Turk, N. Ozdemir, R. Lehmann, M. Roesel, P. Fritz, N. Braun, C. Ulmer, W. Steurer, B. Dagmar, G. Ott, J. Dippon, D. Alscher, M. Kimmel, J. Latus, A. Turkvatan, M. Balci, S. Mandiroglu, B. Seloglu, M. Alkis, M. Serin, Y. Calik, S. Erkula, H. Gorboz, F. Mandiroglu, E. Lindley, M. Cruz Casal, S. Rogers, J. Pancirova, J. Kernc, J. B. Copley, D. Fouque, I. Kiss, Z. Kiss, A. Szabo, J. Szegedi, J. Balla, E. Ladanyi, B. Csiky, O. orkossy, M. Torok, S. Turi, C. Ambrus, G. Deak, A. Tisler, I. Kulcsar, V. K d r, A. Altuntas, A. Akp nar, H. Orhan, M. Sezer, V. Filiopoulos, N. Manolios, D. Arvanitis, I. Pani, K. Panagiotopoulos, D. Vlassopoulos, M. E. Rodriguez-Ortiz, A. Canalejo, C. Herencia, J. M. Martinez-Moreno, A. Peralta-Ramirez, P. Perez-Martinez, J. F. Navarro-Gonzalez, M. Rodriguez, M. Peter, K. Gundlach, S. Steppan, J. Passlick-Deetjen, J. R. Munoz-Castaneda, Y. Almaden, M. Rodriguez-Ortiz, J. Martinez-Moreno, I. Lopez, E. Aguilera-Tejero, N. Hanafusa, I. Masakane, S. Ito, S. Nakai, K. Maeda, H. Suzuki, M. Tsunoda, R. Ikee, N. Sasaki, M. Sato, N. Hashimoto, M.-H. Wang, K.-Y. Hung, C.-K. Chiang, J.-W. Huang, K.-C. Lu, C.-L. Lang, K. Okano, T. Yamashita, Y. Tsuruta, A. Hibi, N. Miwa, N. Kimata, K. Tsuchiya, K. Nitta, T. Akiba, L. Harb, H. Komaba, T. Kakuta, T. Suga, M. Fukagawa, H. Kikuchi, H. Shimada, R. Karasawa, M. Suzuki, M. Zhelyazkova-Savova, D. Gerova, D. Paskalev, V. Ikonomov, R. Zortcheva, B. Galunska, G. Jean, P. Deleaval, J.-M. Hurot, C. Lorriaux, B. Mayor, C. Chazot, H. Vannucchi, M. T. Vannucchi, J. C. Martins, J. L. Merino, J. L. Teruel, M. Fernandez-Lucas, J. J. Villafruela, B. Bueno, A. Gomis, V. Paraiso, C. Quereda, F. H. Ibrahim, N. Z. Fadhlina, E. K. Ng, K. M. Thong, B. L. Goh, D. M. Sulaiman, D. A. N. Fatimah, D. O. Evi, S. R. Siti, R. J. Wilson, M. Keith, B. Gros, A. Galan, J. A. Herrero, I. Oyaguez, M. A. Casado, S. Lucisano, G. Coppolino, A. Villari, V. Cernaro, R. Lupica, D. Trimboli, C. Aloisi, and M. Buemi
Subjects: Oncology, Transplantation, medicine.medical_specialty, Nephrology, business.industry, Internal medicine, medicine, business
Published: 2013

35. Donor cell-derived hematological malignancy: a survey by the Japan Society for Hematopoietic Cell Transplantation

Author: Satoru Takahashi, T Yamashita, Tatsuo Ichinohe, Fumihiko Kimura, Yoshiko Atsuta, Tetsuya Fukuda, Shuichi Taniguchi, Tadakazu Kondo, Chiaki Nakaseko, Hisakazu Nishimori, Ritsuro Suzuki, Kimikazu Matsumoto, K Iwato, Koji Kato, Motohiro Kato, Yoshiko Hashii, and Kazunori Imada
Subjects: Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Donor cell, Adolescent, MEDLINE, Kaplan-Meier Estimate, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Japan, Risk Factors, Internal medicine, medicine, Humans, Transplantation, Homologous, Young adult, Child, Hematopoietic cell, business.industry, Incidence (epidemiology), Incidence, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Tissue Donors, Transplantation, surgical procedures, operative, Hematological malignancy, 030220 oncology & carcinogenesis, Hematologic Neoplasms, Female, Cord Blood Stem Cell Transplantation, business, 030215 immunology
Abstract: Donor cell-derived hematological malignancy: a survey by the Japan Society for Hematopoietic Cell Transplantation
Published: 2016

36. Recent developments in Geant4

Author: Vladimir Grichine, Sebastien Incerti, G.O. Depaola, A. Galoyan, Andrea Dotti, Maria A.M. Reis, T. Yamashita, Enrico Bagli, Davide Mancusi, Ziad Francis, Helmut Burkhardt, J. I. Shin, Pekka Kaitaniemi, K. Amako, Tatsumi Koi, M. Raine, Pedro Arce, Ivan Petrović, John Allison, Nicolas A. Karakatsanis, D. Sawkey, Alexey Bogdanov, Victor Daniel Elvira, Giovanni Santin, X. Dong, Douglas Wright, M.H. Kelsey, S. Y. Jun, Maria Grazia Pia, K. Murakami, P. Gumplinger, S. B. Lee, Makoto Asai, J Perl, Jerome Verbeke, V. V. Uzhinsky, S. Hwang, J. M. Quesada, D. Brandt, Vladimir Ivanchenko, L. Garnier, Giorgio Ivan Russo, A. Mantero, Alexander Bagulya, Francesco Longo, B. Morgan, G. Barrand, Susanna Guatelli, T. Nikitina, Igor Strakovsky, H.N. Tran, Francesco Romano, B. R. Beck, Sw. Banerjee, D. Cano-Ott, M. Gayer, F.W. Jones, Ph Canal, Luciano Pandola, Paul Gueye, Toshiyuki Toshito, M. A. Cortés-Giraldo, Kyung-Suk Cho, Tsukasa Aso, A. Ristic Fira, Alexander Howard, G. Cosmo, Gunter Folger, John Apostolakis, Hisaya Kurashige, Giacomo Cuttone, Ivana Hřivnáčová, B. Tome, E. Mendoza, Stephane Chauvie, M. Karamitrosi, A. Taborda, Gene Cooperman, Satoshi Tanaka, H. Wenzel, B. Wendt, K. Genser, Takashi Sasaki, D. H. Wright, Pete Truscott, L. Urbán, Alberto Ribon, M. Verderi, P. Paprocki, M. Maire, A. Ivanchenko, Akinori Kimura, W. Pokorski, H. Yoshida, Jeremy M. C. Brown, A. Lechner, G.A.P. Cirrone, J. Yarba, Laurent Desorgher, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire d'Orsay (IPNO), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Service des Réacteurs et de Mathématiques Appliquées (SERMA), Département de Modélisation des Systèmes et Structures (DM2S), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Service d’Études des Réacteurs et de Mathématiques Appliquées (SERMA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Allison, J., Amako, K., Apostolakis, J., Arce, P., Asai, M., Aso, T., Bagli, E., Bagulya, A., Banerjee, S., Barrand, G., Beck, B. R., Bogdanov, A. G., Brandt, D., Brown, J. M. C., Burkhardt, H., Canal, Ph., Cano-Ott, D., Chauvie, S., Cho, K., Cirrone, G. A. P., Cooperman, G., CortÃ©s-Giraldo, M. A., Cosmo, G., Cuttone, G., Depaola, G., Desorgher, L., Dong, X., Dotti, A., Elvira, V. D., Folger, G., Francis, Z., Galoyan, A., Garnier, L., Gayer, M., Genser, K. L., Grichine, V. M., Guatelli, S., Guãye, P., Gumplinger, P., Howard, A. S., Hřivnã¡čovã¡, I., Hwang, S., Incerti, S., Ivanchenko, A., Ivanchenko, V. N., Jones, F. W., Jun, S. Y., Kaitaniemi, P., Karakatsanis, N., Karamitrosi, M., Kelsey, M., Kimura, A., Koi, T., Kurashige, H., Lechner, A., Lee, S. B., Longo, F., Maire, M., Mancusi, D., Mantero, A., Mendoza, E., Morgan, B., Murakami, K., Nikitina, T., Pandola, L., Paprocki, P., Perl, J., Petrović, I., Pia, M. G., Pokorski, W., Quesada, J. M., Raine, M., Reis, M. A., Ribon, A., Ristić Fira, A., Romano, F., Russo, G., Santin, G., Sasaki, T., Sawkey, D., Shin, J. I., Strakovsky, I. I., Taborda, A., Tanaka, S., Tomã©, B., Toshito, T., Tran, H. N., Truscott, P. R., Urban, L., Uzhinsky, V., Verbeke, J. M., Verderi, M., Wendt, B. L., Wenzel, H., Wright, D. H., Wright, D. M., Yamashita, T., Yarba, J., and Yoshida, H.
Subjects: MONTE-CARLO DOSIMETRY, LIQUID WATER, Nuclear and High Energy Physics, Exploit, PAIR PRODUCTION, MODELS, Nuclear physics, ENERGY ELECTROMAGNETIC, HEAVY-ION COLLISIONS, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, QA76, 030218 nuclear medicine & medical imaging, High energy physic, 03 medical and health sciences, 0302 clinical medicine, Software, HADRON-NUCLEUS, 0103 physical sciences, PHYSICS PROCESSES, Statistical physics, High energy physics, Adaptation (computer science), Instrumentation, QC, Computing, Radiation, Simulation, ComputingMilieux_MISCELLANEOUS, Nuclear and High Energy Physic, Physics, Physics::Computational Physics, 010308 nuclear & particles physics, business.industry, Detector, NUCLEUS CROSS-SECTIONS, SPACE EVENT GENERATOR, Variety (cybernetics), Visualization, Computing and Computers, MICRODOSIMETRY SIMULATION, Nuclear physic, Multithreading, Nuclear Physics - Theory, Systems engineering, Space Science, business
Abstract: Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here., Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 835, ISSN:0168-9002, ISSN:1872-9576
Published: 2016

37. Development of the X'tal Cube: A 3D Position-Sensitive Radiation Detector With All-Surface MPPC Readout

Author: Yujiro Yazaki, Takayuki Mitsuhashi, Eiji Yoshida, Fumihiko Nishikido, Hideo Murayama, Naoko Inadama, M. Watanabe, T. Yamashita, Mikio Suga, Taiga Yamaya, and Kengo Shibuya
Subjects: Physics, Nuclear and High Energy Physics, Scintillation, business.industry, Detector, Photodetector, Scintillator, Particle detector, Crystal, Optics, Nuclear Energy and Engineering, Nuclear electronics, Electrical and Electronic Engineering, Cube, business
Abstract: We have developed a new three-dimensional (3D) position sensitive radiation detector, called the X'tal cube. The X'tal cube is composed of a scintillation crystal block and a number of multi-pixel photon counters (MPPCs) which are coupled on all six sides of the block. The block is segmented into cubes and no reflector is used between the segments. Scintillation light originating in a crystal segment accordingly propagates three-dimensionally along the alignment of the crystal segments and is efficiently detected by the MPPCs. The X'tal cube could be used as the detector element of a PET system, for instance. We constructed two prototypes of the X'tal cube and evaluated their performance using gamma-ray sources. The crystal block of each prototype is composed of a 3D array of Lu2xGd2(1-x)SiO5: Ce (LGSO, x = 0.9) crystal segments. Each crystal volume is 3.0 mm x 3.0 mm x 3.0 mm. MPPCs of a 3.0 mm x 3.0 mm active area are coupled to each surface of the crystal block. In this work, we show that all crystal segments are identified by a simple Anger-type calculation performed on the MPPC signals for both prototypes. The X'tal cube provides high spatial resolution in three dimensions regardless of the incident angle of the radiation.
Published: 2012

38. Development of Energy-Efficient Cryogenic Leads with High Temperature Superconducting Films on Ceramic Substrates

Author: Richard R. Taylor, R.J. Webber, Alexey V. Pan, Olga V Shcherbakova, Sergey A. Fedoseev, Oleg A. Mukhanov, Shi Xue Dou, Igor A. Golovchanskiy, Sihai Zhou, and T. Yamashita
Subjects: YBCO films, Permittivity, Superconductivity, Materials science, business.industry, Substrate (electronics), Physics and Astronomy(all), Microstrip, Pulsed laser deposition, data cables, Pulsed-laser deposition (PLD), visual_art, visual_art.visual_art_medium, Optoelectronics, Vacuum chamber, Ceramic, Thin film, business
Abstract: High temperature superconductor (HTS) material can be used for the implementation of high-speed low-heat conduction data links to transport digital data from 4 K superconductor integrated circuits to higher-temperature parts of computing systems. In this work, we present a conceptual design of energy efficient interface and results in fabricating such HTS leads. Initial calculations have shown that the microstrip line cable geometry for typical materials employed in production of HTS thin films can be a two-layered film for which the two layers of about 10 cm long are separated by an insulation layer with as low permittivity as possible. With this architecture in mind, the pulsed laser deposition process has been designed in a 45 cm diameter vacuum chamber to incorporate an oscillating sample holder with homogeneous substrate heating up to 900°C, while the laser plume is fixed. This design has allowed us to produce 200 nm to 500 nm thick, 7 cm to 10 cm long YBa2Cu3O7 thin films with the homogeneous critical temperature (Tc) of about 90 K. The critical current density (Jc) of the short samples obtained from the long sample is of (2 ± 1) × 1010 A/m2. Lines of 3-100 μm wide have been successfully patterned along the length of the samples in order to directly measure the Tc and Jc values over the entire length of the samples, as well as to attempt the structuring of multichannel data lead prototype.
Published: 2012

39. Reduction of intracerebral hemorrhage by rivaroxaban after tPA thrombolysis is associated with down-regulation of PAR-1 and PAR-2

Author: Koji Abe, T. Yamashita, and Ryuta Morihara
Subjects: Intracerebral hemorrhage, medicine.medical_specialty, Rivaroxaban, business.industry, medicine.medical_treatment, Thrombolysis, medicine.disease, Neurology, Internal medicine, Cardiology, medicine, Neurology (clinical), business, Reduction (orthopedic surgery), medicine.drug
Published: 2017

40. Robust Contour Tracking by Combining Region and Boundary Information

Author: Xin Yang, Lei He, Yiren Xu, T. Yamashita, Ling Cai, and Yuming Zhao
Subjects: Computer science, business.industry, Kernel density estimation, Feature extraction, Initialization, Pattern recognition, Object detection, Kernel method, Robustness (computer science), Video tracking, Motion estimation, Media Technology, Artificial intelligence, Electrical and Electronic Engineering, business
Abstract: This paper presents a new object tracking model that systematically combines region and boundary features. Besides traditional region features (intensity/color and texture), we design a new boundary-based object detector for accurate and robust tracking in low-contrast and complex scenes, which usually appear in the commonly used monochrome surveillance systems. In our model, region feature-based energy terms are characterized by probability models, and boundary feature terms include edge and frame difference. With a new weighting term, a novel energy functional is proposed to systematically combine the region and boundary-based components, and it is minimized by a level set evolution equation. For an efficient computational cost, motion information is utilized for new frame level set initialization. Compared with region feature-based models, the experimental results show that the proposed model significantly improves the performance under different circumstances, especially for objects in low-contrast and complex environments.
Published: 2011

41. Petascale Computation for Earthquake Engineering

Author: H. Muneo, K. Kajiwara, and T. Yamashita
Subjects: Earthquake engineering, General Computer Science, ComputingMethodologies_SIMULATIONANDMODELING, business.industry, Computer science, InformationSystems_INFORMATIONSYSTEMSAPPLICATIONS, Computation, General Engineering, Numerical models, GeneralLiterature_MISCELLANEOUS, Construction engineering, Computational science, Petascale computing, Earthquake simulation, Earthquake hazard, Project management, business
Abstract: Two research projects are working toward petascale computation for earthquake engineering. The E-Simulator project aims to reproduce a world-class shake-table test, while the Integrated Earthquake Simulation (IES) project seamlessly simulates three key earthquake processes to provide vital information about potential earthquake hazards and disasters.
Published: 2011

42. Study on detection of the early signs of derailment for railway vehicles

Author: C. Hung, T. Yamashita, Masahiko Aki, Tetsuya Kawanabe, T. Tsuji, Yoshihiro Suda, Takashi Kunimi, and M. Morikawa
Subjects: Truck, Engineering, Derailment, business.industry, Mechanical Engineering, Poison control, Angular velocity, Bogie, Automotive engineering, Vehicle dynamics, Acceleration, Automotive Engineering, Safety, Risk, Reliability and Quality, business, Scale model
Abstract: This paper proposes a technique for detecting the early signs of derailment of a railway vehicle. The proposed system detects abnormal vehicle signs before derailment using micro-electromechanical system acceleration sensors for automobiles. A derailment detection algorithm has been investigated using derailment simulations and experiments. A numerical analysis with a scaled vehicle model simulating wheelclimb derailment at low speeds has been examined. A scale model of a railway vehicle, including one carbody with two bogies, as well as an original device that can simulate various wheelclimb derailments for the selected wheel was designed and made. Based on a numerical analysis and scaled derailment experiments, an algorithm for detecting the signs of derailment beforehand has been proposed and verified. It is found that, using the peak threshold of the pitch angular rate and the integral threshold of the roll angular rate of the truck frame, it is possible to detect the signs of the derailment.
Published: 2010

43. Development of PET Detectors Using Monolithic Scintillation Crystals Processed With Sub-Surface Laser Engraving Technique

Author: Tatsuki Okamoto, S. Ohsuka, T. Yamashita, Kenshi Fukumitsu, H. Takahashi, Mitsuo Watanabe, T. Sakai, and Takahiro Moriya
Subjects: Nuclear and High Energy Physics, Photomultiplier, Scintillation, Laser ablation, Materials science, Physics::Instrumentation and Detectors, business.industry, Laser engraving, Photodetector, Physics::Optics, Engraving, Laser, Lyso, law.invention, Crystal, Optics, Nuclear Energy and Engineering, law, visual_art, Nd:YAG laser, Scintillation counter, visual_art.visual_art_medium, Optoelectronics, Electrical and Electronic Engineering, business
Abstract: New monolithic scintillation detectors for PET have been developed, where the crystals are processed using internal focused laser processing technique, which is called subsurface laser engraving (SSLE) technique. When high intensity light pulses of short duration from a laser are focused into a scintillation crystal, they induce multi-photon absorption at the focal point and result in refractive index changes or micro-cracks inside the crystal. By applying the SSLE technique to a monolithic scintillation block, fine segmentation in the crystal can be formed without inter-pixel gaps. We have fabricated 2D segmented arrays engraved various patterns of micro-cracks inside monolithic LYSO crystal blocks by using a Nd:YAG laser. The processed crystal array segmented to 12 × 12 with 1.67 mm pitch have been evaluated by coupling to a position-sensitive photomultiplier tube (PS-PMT). The 2D position histograms were measured for uniform irradiation of gamma-rays and each crystal segment was clearly separated. The average energy resolution was 9.7%, similar to that of the conventional arrays, so that the laser processed LYSO crystals have kept their primary scintillation properties. We have also evaluated the laser processed crystals by using multi-pixel photon counters (MPPCs) to investigate the possibilities as a future PET detector. These results suggest that it is possible to fabricate high performance PET detectors using the SSLE technique.
Published: 2010

44. Tumor immunity and immunosurveillance (PP-093)

Author: G. Bi, K. Hanada, M. Maeda, W. J. Norde, A. Piwko-Czuchra, M. Hojjat-Farsangi, C. Tsai, G. Ball, C. Sarkar, Alireza Razavi, U. Yamashita, A. Jamali, O. Gavriliuc, S. Darzi, W. Wang, V. Subr, Y. Endo, M. Mehrabi Bahar, M. Hung, M. W. L. Teng, M. Miiluniemi, R. Sen, S. Bae, H. C. Hung, A. Anjomshoaa, L. Cazin, D. Zhao, I. J. Shubina, R. Maekawa, M. Shin-ya, M. Pfreundschuh, S. M. ElZoghaby, T. A. Luger, A. Nabi, N. Minato, Y. Kao, M. S. Alam, R. Spisek, M. Maki, V. Huovinen, T. Murata, R. Anderson, E. Nicholson, M. van Egmond, J. Tomala, C. Wang, W. Sun, M. Momeny, S. Lee, M. L. Mora-García, N. Alizadeh, D. Jin, I. Comerford, E. P. Kisseleva, R. M. Talaat, S. Kim, D. Wakita, J. Strid, M. Shimomura, S. Wang, Y. Tamura, Y. Tanaka, J. Ichikawa, M. Inaba, H. Lee, R. Nohra, P. Hu, J. Sun, N. Okazaki, K. Franciszkiewicz, G. M. Fadaly, M. Maksimow, A. Rosca, W. L. Olszewski, T. Inozume, Y. Zhang, S. F. Ngiow, H. K. Takahashi, M. H. Huang, S. Hashino, H. Li, K. S. Titov, H. C. Toh, H. Lim, T. Yaguchi, M. Bögels, B. Kubuschok, M. Wang, G. Nunez, A. Pourazar, F. Mami-Chouaib, P. Rossmann, K. Moriya, A. Eric, N. Li, S. Ichimiya, R. Kumar, H. Mao, L. H. El Sayed, T. Chen, I. Kuiatse, Y. M. Tzeng, A. V. Schattenberg, G. Kristiansen, Y. Mizote, P. Lei, Y. Harata-Lee, H. Ihn, M. R. Khorramizadeh, M. R. Egeler, B. Sumer, H. Kim, S. Gnjatic, C. K. Lee, R. Kiessling, Y. Tomita, Y. Ji, E. A. Starickova, J. Kopecny, E. Nakazawa, M. W. Teng, D. J. DiLillo, M. E. Castro-Manrreza, S. N. M. AbouRawach, J. C. Wallace, Mahmood Jeddi-Tehrani, H. I. Huang, T. Sakurai, F. Golsaz Shirazi, M. Schaap, Y. Nishimura, N. M. AbouRawach, W. Yang, A. Zamani, S. Hong, A. Wakabayashi, K. Berg Lorvik, W. Shi, E. Nakayama, V. Raina, D. Jung, D. J. Cole, A. Hosoi, B. Becher, L. Keyue, T. Torigoe, J. Hasheminia, H. Matsuda, Y. Adachi, V. Bronte, E. Kato, M. H. Andersen, B. Weiss-Steider, K. Sumida, A. Gruia, M. Voskort, M. Mandai, H. Baba, A. Korman, Z. Qin, M. Khorramizadeh, B. Rihova, G. E. Lyons, H. Yoon, T. Tang, C. A. Hansen, M. Nakatsugawa, Y. Kim, C. Soderberg Naucler, M. Harada, P. Kralikova, M. Hajzadeh, M. Hoseinipanah, A. Uenaka, S. Inoda, C. Gest, N. Shibagaki, M. Quigley, O. S. Naga, J. Chen, H. Liu, T. Ito, M. Saberi-Firoozi, J. Khoshnoodi, F. Zhu, H. M. Ghoneim, R. Esmaeili, Z. Jahanshiri, J. Lee, Y. Hirohashi, N. Hosaka, A. Berahmeh, M. Bodogai, I. Markovic, N. Fu, M. Hong, Y. Kanthaiah, J. D. Holland, J. King, H. S. Kang, X. Huang, M. Brenner, S. Anghel, S. Nagoya, J. Soria, I. Konishi, M. Kato, J. Shin, N. Sato, R. Beelen, G. K. Brown, Y. J. Zhuang, K. Ulbrich, S. Senju, T. Kishida, J. Fucikova, J. Kim, Iwona Hus, F. Xu, M. Inoue, M. Shabani, Lorenzo Mortara, L. Zheng, S. Ghaffari, N. Ozoren, K. Nakatsuka, E. Gélizé, M. Zhang, R. Korenstein, W. Li, P. Marrack, A. Feng, B. Toh, N. Matsumura, R. A. Kemp, J. Hernández-Montes, S. Werner, C. M. Diaz-Montero, H. Hayashi, X. Zha, T. F. Tedder, Y. Wu, E. Torkabadi, A. Choudhury, M. Asaka, Y. Bi, C. C. Johansson, K. Kakimi, Y. G. Mansurova, K. Oida, Y. Kusumoto, M. J. Smyth, C. J. Chen, H. L. Dong, Jamshid Hadjati, I. Besu-Zizak, T. Takeuchi, O. Buyanovskaya, A. V. Krylov, I. Juko-Pecirep, M. A. Firer, A. Girardin, M. Fukuda, K. T. Y. H. Hiroshi Shiku, I. Mahmud, S. Jalkanen, S. H. Tu, N. K. Akhmatova, M. Hajimoradi, K. Udaka, X. Zhang, S. Beissert, Y. Urade, K. Ghaffarzadehgan, J. Strohalm, Z. Han, C. Akekawatchai, X. Cao, M. V. Kiselevsky, Y. Keisari, T. Tan, T. Yoshikawa, S. Muto, D. Mougiakakos, H. Dolabi, Q. Wang, H. Nakano, S. R. Hadrup, V. Frangione, Roberto S. Accolla, Y. Hwang, H. Mochimaru, R. Okita, K. Ohmori, H. Sima, J. Prieto, S. A. Rosenberg, I. Poschke, M. I. Nishimura, J. Medina, P. Wen, Y. Lu, R. Hadavi, A. Corthay, Y. Kawakami, S. Bao-en, M. Yousefi, M. S. Hassan, M. Torabi Rahvar, S. Mohanty, P. Nagarkatti, E. A. Lebedinskaya, Y. Li, V. Paunescu, Y. Zheng, E. Hafez, Y. H. Lee, W. Song, K. Soliman, W. Gao, M. Matsui, Z. Juranic, K. Hebeda, R. Gress, T. Kishimoto, C. Zhang, Q. Xie, C. A. Rosenstadt, K. Klimesova, J. Zhou, S. Kawaguchi, B. Clausen, J. Jiang, Magdalena Wasiak, N. Sakemura, J. L. Teillaud, H. M. Koheil, M. Ahmad, N. Ding, M. Jevric, I. V. Lyamina, Z. Zakostelska, M. Soengas, T. Takaki, H. Dai, D. Mehrabani, K. Aritake, D. Chen, J. Kato, M. Djordjevic, S. Fukushima, I. M. Svane, A. Rahbar, T. Nishimura, B. Kharma, M. W. Schilham, I. Entin, B. von Scheidt, T. Taguchi, Y. Nakashima, D. Preuss, K. Mimura, A. Tominaga, T. Fujita, K. Kido, H. Raziee, S. Ikehara, T. Komatsu, H. Yagura, Y. Yoshida, G. Capone, X. Wang, R. Varin, N. Kumagai, M. Kochetkova, A. Hayday, M. Karikoski, Chun-Yen Chang, H. Maeng, S. Sugawara, S. Ghadri, H. Chmelova, A. Sun, W. Pei'e, L. A. Sherman, A. Puaux, A. Amari, E. Saller, W. H. Fridman, N. Junker, M. Sarafraz yazdi, K. Wejksza, M. Kovar, H. Yang, C. Hu, Y. Arima, A. Le Floc'h, Y. Nakamura, R. Morita, Y. Iwakura, H. Oster, M. Zabala, I. Z. Matic, V. Chew, A. Memarian, G. Jiang, B. Huang, I. Hammami, T. N. M. Schumacher, P. Vossough, N. Tsukamoto, V. I. Lioudyno, M. Sirova, M. Oka, J. Eyles, H. Madadi, H. Stauss, A. Itai, L. U'Ren, B. Tsai, H. W. Chen, X. Qu, R. García-Rocha, Y. Goto, H. Ozaki, Patrizia Castellani, Q. Shao, K. Wang, A. Talei, E. Ivansson, C. L. Wang, J. J. Montesinos-Montesinos, H. Dolstra, D. Nistor, M. Li, S. Hirata, T. Etrych, X. M. Gao, L. Li, O. Mazda, D. Andrews, B. Ansaripour, P. Yotnda, Q. J. Wang, T. Tsukahara, J. Bartunkova, H. Lei, H. Fredrix, A. De Lerma Barbaro, G. R. Fajardo-Orduña, Paulina Wdowiak, L. Gunn, W. Zuo, Q. Zhang, T. Sparwasser, S. Chen, Y. Yang, L. Liu, Y. Kikuchi, T. Aji, S. Nakai, K. H. Lim, M. M. Andalib, H. Norell, U. V. Ozkurede, T. Shimada, A. Andalib, J. Slansky, Xiao-Tong Yuan, P. Chong, Y. Miura, J. Inoue, T. Yamashita, Y. Faghani, S. Hosseini, H. Hosseinnezhad, K. Dan, Q. Liu, C. Park, A. Prevost-Blondel, A. Tomar, H. Pfister, S. Okano, H. Harimoto, H. J. Baelde, S. Shimada, J. Vom Berg, B. Deng, J. C. Becker, S. Samarghandian, A. K. Chávez-Rueda, J. C. Yang, A H Zarnani, T. Nakatsura, N. Erfani, R. van der Voort, R. C. Rees, X. Wen, V. Gutierrez-Serrano, H. Kishimoto, A. Ghaderi, H. Ren, Y. Zhong, A. Lankester, A. Amini, S. A. Williams, G. Jin, M. Mittelman, P. Thor Straten, I. Ng, T. Suzuki, C. Tovar, N. Harashima, Y. Oshima, I. V. Oradovskaya, M. Mahmoudian, I. C. Le Poole, Y. Furukawa, V. Budinsky, Y. Liu, M. Hori, Nazanin Mojtabavi, H. Rabbani, S. A. Shamsdin, Z. Tayarani, H. Fan, Y. Hayashida, K. Iwamura, B. Bogen, S. Vivekanandhan, V. Phillips, L. Berge-Hansen, Q. Yin, N. Lee, Y. Sasaki, Q. Li, M. Nishibori, K. Sato, N. D. Spivey, G. Y. Liu, H. Asanuma, H. Kang, R. Ophir, H. Mellstedt, D. Crisnic, A. Irie, J. Klarquist, B. Seliger, H. Wake, N. McLaughlin, S. Park, D. Vetvicka, J. T. Baran, I. Gustavsson, N. Arandi, Y. Sher, J. Kong, T. Ando, L. Volkova, J. Yan, H. Fang, N. Matumura, M. Arjipour, D. Handke, M. Ghasemi, A. E. Reeve, P. Berraondo, O. Hovorka, P. Chow, R. A. Sharifian, G. Shen, G. Hu, S. J. Liu, R. Abès, H. Takahashi, Anna Dmoszynska, C. A. Don-López, N. Tajik, H. Hwang, N. Gül, K. Horie, N. Rahbar-Roshandel, F. M. Bojin, D. Li, J. Hamanishi, H. Heslop, Jacek Roliński, M. Shimizu, J. Wang, T. Hirano, H. Sumimoto, R. B. Sørensen, G. M. Woods, N. Borojevic, S. Stevanovic, M. K. Zaman, Z. Fu, E. Morris, A. Al-Khami, M. Kverka, W. Shi-jie, A. Yano, M. Gewartowska, H. Okuyama, S. Kale, J. P. Vannier, F. Ciuculescu, K. Loser, Z. Zhang, U. Joimel, F. M. Maas, C. Lemetre, A. H. M. Taminiau, J. Tavakkol Afshari, M. Sang, M. Cristea, D. Tobi, M. Motamedi, X. Zhao, Y. Hisa, J. P. Abastado, S. I. Lin, L. Cao, Y. Yoshioka, M. Isobe, M. Murakami, H. Hisha, V. Younesi, N. Krug, M. Ahmadzadeh, E. Saka, Z. Zhan, C. Bunu, A. Monroy-García, S. Wu, Y. Ohue, B. Matharoo-Ball, A. Emami, R. Bos, F. Shokri, W. Xing, T. Suda, O. V. Lebedinskaya, J. Ishizaki, T. Ramadan, G. Brown, S. Mori, A. Rezaei, H. Haro, R. Xia, T. Tsunoda, Y. Narita, Y. Jin, A. Biragyn, H. Irjala, P. C. W. Hogendoorn, J. Betka, C. Kudo-Saito, S. Xiaobai, Y. Sung, M. Moscicka-Wesolowska, T. Baba, A. Saad, W. Lee, A. A. Pourfathollah, G. R. Hill, A. Davari sadat, M. Hattori, J. Nisanov, S. Santos, L. Chen, P. Vosough, J. Zhang, T. Martins da Palma, T. M. de Witte, Z. M. Hassan, A. Kreiss, Y. Saitou, L. Zhang, S. R. McColl, T. Hudcovic, J. Yeh, M. Oft, L. Jianing, L. Han, K. Kitaoka, O. Moaven, X. Liu, X. Ren, C. A. Taher, H. Kitamura, A. Tanaka, Y. Ikuta, N. Ardaiz, S. Arab, J. Fioravanti, Agnieszka Bojarska-Junak, S. Rezaie, H. Tlaskalova Hogenova, A. Takahashi, C. Soria, W. Zibing, T. Wan, J. Kang, U. Gyllensten, A. Swanson, L. Ong, X. Jiang, M. M. Amiri, M. Ahmadi, S. Fan, C. A. Tatu, D. Berghuis, T. Abdolahi, J. Guosheng, A. Nardin, H. Asgarian-Omran, B. Vafadar-Isfahani, M. Salmi, S. Smola, R. Saeedi, R. Imamura, M. Jolicoeur, S. Liu, L. Yang, P. Wang, L. L. Pritchard, Z. Li, B. Damdinsuren, X. Lu, M. Lee, T. Nakagawa, J. Liu, B. Chiang, G. Tanasie, M. Kano, S. Ngiow, M. Nooridaloii, M. Antsiferova, K. Harada, S. Eikawa, M. Eisenring, F. Neumann, J. R. Wunderlich, K. Yoshimoto, K. Abiko, T. Otsuki, M. Jafarzadeh, Y. F. Liao, E. Blot, Y. Nagai, G. De Crescenzo, M. Yekaninejad, Y. Noguchi, M. Nagarkatti, P. B. Olkhanud, M. Inic, C. Prakash, C. Tatu, S. Ono, A. Lindbloom, F. Marttila-Ichihara, R. Abe, T. Okamoto, and K. Yanaba
Subjects: Immunosurveillance, business.industry, Immunology, Cancer research, Immunology and Allergy, Medicine, General Medicine, Tumor immunity, business
Published: 2010

45. Reduction of pitch of nanohole array by self-organizing anodic oxidation after nanoimprinting

Author: Masashi Nakao, Tomohiro Shimizu, T. Yamashita, Shoso Shingubara, and S. Maruo
Subjects: Materials science, Anodizing, business.industry, Nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Anode, Reduction (complexity), Nanohole array, chemistry.chemical_compound, Nanolithography, chemistry, Aluminium oxide, Miniaturization, Optoelectronics, Electrical and Electronic Engineering, business, Voltage
Abstract: We investigated a method for controlling the regularity of a single-domain triangular array of nanoholes in anodic aluminum oxide (AAO); the method is a combination of a nanoimprinting method and self-organization. We found that it was possible to reduce a nanohole pitch of AAO to 1/3 of the pitch of the nanoimprinting mold, by the choice of an appropriate anodic voltage. The regularity of the nanohole array was quantitatively evaluated using the FFT method, and the best regularity was obtained at 46V; at this voltage, the pitch of the nanohole array was decreased to 115nm from 200nm of the nanoimprinting mold. This method suggests the possibility of decreasing the nanohole pitch by using a top-down technique such as nanoimprinting and an appropriate choice of the anodic voltage.
Published: 2010

46. Effect of glimepiride and nateglinide on serum insulin and glucose concentration in healthy cats

Author: T. Yamashita, Toshiro Arai, Akihiro Mori, Hisashi Mizutani, Toshinori Sako, Y. Nishimaki, Hitomi Oda, Peter Lee, T. Honjo, Katsumi Ishioka, Kaori Saeki, and Yohei Miki
Subjects: Blood Glucose, Male, medicine.medical_specialty, Phenylalanine, medicine.medical_treatment, Blood sugar, Nateglinide, Pharmacology, Cat Diseases, Blood serum, Cyclohexanes, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Animals, Hypoglycemic Agents, Insulin, CATS, General Veterinary, business.industry, Type 2 Diabetes Mellitus, General Medicine, Glucose Tolerance Test, medicine.disease, Glimepiride, Sulfonylurea Compounds, Endocrinology, Cats, Female, business, medicine.drug
Abstract: Glimepiride and nateglinide are two common oral hypoglycemic agents currently being used with humans suffering from Type 2 diabetes mellitus. Neither drug has been tested with cats thus far and it is currently unknown whether either of these drugs exert any effect in cats or not. The objective of this study was to determine the effect of glimepiride and nateglinide on glucose and insulin responses in healthy control cats, in order to determine their potential use in diabetic cats. The intravenous glucose tolerance tests was carried out since it is an excellent test for evaluating pancreatic beta-cell function for insulin secretion. Alterations in the insulin secretion pattern can be perceived as the earliest sign of beta-cell dysfunction in many species, including cats. Nateglinide demonstrated a quick action/short duration type effect with serum glucose nadiring and insulin response peaking at 60 and 20 minutes, respectively. Alternatively, glimepiride is medium-to-long acting with serum glucose nadiring and insulin response peaking at 180 minutes and 60 minutes, respectively. Nateglinide's potency was evident allowing it to induce a 1.5-2 higher preliminary insulin peak (3.7 +/- 1.1 pg/ml) than glimepiride's (2.5 +/- 0.1 pg/ml), albeit only for a short period of time. Because glimepiride and nateglinide have a shared mode of action, no significant differences in overall glucose AUC(0-360 min) (24,435 +/- 2,940 versus 24,782 +/- 2,354 mg min/dl) and insulin AUC(0-360 min) (410 +/- 192 versus 460 +/- 159) in healthy control cats were observed. These findings may provide useful information when choosing a hypoglycemic drug suited for the treatment of diabetic cats depending on the degree of diabetes mellitus the cat is suffering from.
Published: 2009

47. Development of a Small Animal PET Scanner Using DOI Detectors

Author: Tomohide Omura, Eiichi Tanaka, Nakahiro Sato, K. Sakai, K. Shimizu, Takahiro Moriya, Kibo Ote, T. Yamashita, M. Takahashi, R. Yamada, M. Watanabe, and A. Katabe
Subjects: Physics, Nuclear and High Energy Physics, Scanner, business.industry, Point source, Amplifier, Resolution (electron density), Detector, Lyso, Cross section (geometry), Full width at half maximum, Optics, Nuclear Energy and Engineering, Electrical and Electronic Engineering, business
Abstract: A small animal PET scanner using 256-channel PS-PMTs has been designed, constructed, and evaluated. The scanner has twelve detector modules, each of which consists of a double-layer array of LYSO crystals and three PS-PMTs (Hama- matsu R8400-00-M256). In the LYSO crystal block, 32 times 53 crystal elements are optically coupled to 32 times 54 crystal elements with a shift of half the element pitch in the axial direction. The dimension of each crystal element is 1.275 times 2.675 mm2 in cross section and 7 mm in depth. The twelve detector modules are positioned on a 182 mm diameter ring to form 107 detector rings with 1.4 mm pitch. The transaxial FOV is 100 mm in diameter and the axial FOV is 151 mm, which is sufficient to cover the whole body of a mouse. In order to compensate for non-uniform outputs from the multi-anodes of the PS-PMTs, ASICs having 64-channel variable gain amplifiers and summing amplifiers are used in the front-end circuits. The preliminary experimental results are the transaxial resolution of 2.0 mm FWHM in the CFOV, and the axial resolution of 2.8 mm FWHM on the axis of the ring. The absolute coincidence sensitivity is 8.1% for a point source at the CFOV with setting an energy window of 350-750 keV and a timing window of 10 ns. The applicable imaging capability of the scanner was demonstrated by animal studies with a rat.
Published: 2008

48. TUNING OF PHOTONIC CRYSTAL BAND PROPERTIES BY ATOMIC LAYER DEPOSITION

Author: C.W. Neff, T. Yamashita, John Blair, Elton Graugnard, Davy P. Gaillot, and Christopher J. Summers
Subjects: Materials science, Physics and Astronomy (miscellaneous), business.industry, Superlattice, Photonic integrated circuit, Physics::Optics, Dielectric, Yablonovite, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Band bending, Optoelectronics, Photonics, business, Electronic band structure, Photonic crystal
Abstract: We report the application of atomic layer deposition to manipulate the dielectric architecture of conventional and superlattice two-dimensional photonic crystal waveguides fabricated in silicon. Conformal deposition of a second dielectric layer is shown to have a dramatic influence on the photonic band structure and produces unique effects that cannot be emulated in a single dielectric slab photonic crystal material. With additional dielectric coatings, a strong decrease in photonic band frequencies and change in band slope are observed, which for the lowest photonic states produces strong degeneracies. The capability, in principle, to tune the position of bands to within 0.005% accuracy, is demonstrated. Additionally, new features are observed when differential band shifts result in band-crossing and for which like polarizations activate perturbation mechanisms that result in local and strong band curvatures. The extremely strong band bending resulting from band-band interactions could have applications, in slow light devices, and provide a way to introduce non-linear effects into tunable photonic crystal structures.
Published: 2008

49. The POLARBEAR-2 and the Simons Array Experiment

Author: Peter A. R. Ade, O. Zahn, Gabriel M. Rebeiz, Suguru Takada, Josquin Errard, D. Poletti, Zigmund Kermish, K. Mizukami, Carlo Baccigalupi, Darcy Barron, Neil Goeckner-Wald, Theodore Kisner, Christopher Raum, G. Hall, R. Dunner, Joshua Montgomery, Tucker Elleflot, Paul L. Richards, A. J. Gilbert, Stephen M. Feeney, M. Navaroli, T. Fujino, Nathan Stebor, Aritoki Suzuki, S. Takatori, D. Boettger, M. A. Dobbs, J. Kaufman, T. Yamashita, Eric V. Linder, Giulio Fabbian, Y. Akiba, Adrian T. Lee, A. Tikhomirov, B. Westbrook, Tomotake Matsumura, Jose H. Groh, Amy N. Bender, Masaya Hasegawa, Scott Chapman, Brian Keating, Colin Ross, Nathan J. Miller, Y. Hori, Radek Stompor, L. Howe, Reijo Keskitalo, A. Ducout, H. Nishino, A. Cukierman, G. Jaehnig, Takayuki Tomaru, I. Shirley, K. M. Rotermund, Osamu Tajima, Masashi Hazumi, D. Leon, Christian L. Reichardt, Kam Arnold, Blake D. Sherwin, Praween Siritanasak, J. Peloton, Kaori Hattori, T. Hamada, L. Lowry, M. Le Jeune, C. Aleman, Giuseppe Puglisi, Jun-ichi Suzuki, F. Irie, Akito Kusaka, W. Holzapfel, O. B. Jeong, Julian Borrill, Chang Feng, A. Zahn, Yuji Chinone, Nobuhiko Katayama, N. Whitehorn, Y. Segawa, K. Kazemzadeh, S. Takakura, Andrew H. Jaffe, N. W. Halverson, T. de Haan, Yuki Inoue, Frederick Matsuda, C. Hill, G. Fuller, Université Paris-Sorbonne (UP4), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), POLARBEAR, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Suzuki, A, Ade, P, Akiba, Y, Aleman, C, Arnold, K, Baccigalupi, C, Barch, B, Barron, D, Bender, A, Boettger, D, Borrill, J, Chapman, S, Chinone, Y, Cukierman, A, Dobbs, M, Ducout, A, Dunner, R, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fujino, T, Fuller, G, Gilbert, A, Goeckner-Wald, N, Groh, J, Haan, T, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hattori, K, Hazumi, M, Hill, C, Holzapfel, W, Hori, Y, Howe, L, Inoue, Y, Irie, F, Jaehnig, G, Jaffe, A, Jeong, O, Katayama, N, Kaufman, J, Kazemzadeh, K, Keating, B, Kermish, Z, Keskitalo, R, Kisner, T, Kusaka, A, Jeune, M, Lee, A, Leon, D, Linder, E, Lowry, L, Matsuda, F, Matsumura, T, Miller, N, Mizukami, K, Montgomery, J, Navaroli, M, Nishino, H, Peloton, J, Poletti, D, Puglisi, G, Rebeiz, G, Raum, C, Reichardt, C, Richards, P, Ross, C, Rotermund, K, Segawa, Y, Sherwin, B, Shirley, I, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, J, Tajima, O, Takada, S, Takakura, S, Takatori, S, Tikhomirov, A, Tomaru, T, Westbrook, B, Whitehorn, N, Yamashita, T, Zahn, A, Zahn, O, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sorbonne ( UP4 ), AstroParticule et Cosmologie ( APC - UMR 7164 ), and Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA )
Subjects: Cosmic microwave background, Inflation, Gravitational weak lensing, Polarization, B-mode, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], cosmic background radiation, 7. Clean energy, 01 natural sciences, pixel, optical, General Materials Science, neutrino: mass, [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Weak gravitational lensing, Mathematical Physics, Physics, Settore FIS/05, Astrophysics::Instrumentation and Methods for Astrophysics, Polarization (waves), Condensed Matter Physics, Atomic and Molecular Physics, and Optics, astro-ph.CO, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, General Physics, noise, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Frequency band, Classical Physics, Cosmic background radiation, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Noise-equivalent temperature, Optics, Settore FIS/05 - Astronomia e Astrofisica, gravitation: lens, bolometer, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010308 nuclear & particles physics, business.industry, Gravitational wave, gravitational radiation, temperature, sensitivity, Transition edge sensor, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], astro-ph.IM
Abstract: We present an overview of the design and status of the \Pb-2 and the Simons Array experiments. \Pb-2 is a Cosmic Microwave Background polarimetry experiment which aims to characterize the arc-minute angular scale B-mode signal from weak gravitational lensing and search for the degree angular scale B-mode signal from inflationary gravitational waves. The receiver has a 365~mm diameter focal plane cooled to 270~milli-Kelvin. The focal plane is filled with 7,588 dichroic lenslet-antenna coupled polarization sensitive Transition Edge Sensor (TES) bolometric pixels that are sensitive to 95~GHz and 150~GHz bands simultaneously. The TES bolometers are read-out by SQUIDs with 40 channel frequency domain multiplexing. Refractive optical elements are made with high purity alumina to achieve high optical throughput. The receiver is designed to achieve noise equivalent temperature of 5.8~$\mu$K$_{CMB}\sqrt{s}$ in each frequency band. \Pb-2 will deploy in 2016 in the Atacama desert in Chile. The Simons Array is a project to further increase sensitivity by deploying three \Pb-2 type receivers. The Simons Array will cover 95~GHz, 150~GHz and 220~GHz frequency bands for foreground control. The Simons Array will be able to constrain tensor-to-scalar ratio and sum of neutrino masses to $\sigma(r) = 6\times 10^{-3}$ at $r = 0.1$ and $\sum m_\nu (\sigma =1)$ to 40 meV., Comment: Accepted to Journal of Low Temperature Physics LTD16 Special Issue, Low Temperature Detector 16 Conference Proceedings, 5 pages, 1 figure
Published: 2015

50. On Amblyopia � Its Definition, and the Results of the Treatment

Author: T. Yamashita
Subjects: medicine.medical_specialty, business.industry, Ophthalmology, medicine, Optometry, business
Published: 2015

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Database

Publisher

475 results on '"T Yamashita"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources