Author: "Sundaresan A" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

1,480 results on '"Sundaresan A"'

1. Comprehensive Analysis of SARS-COV-2 Drug Targets and Pharmacological Aspects in Treating the COVID-19

Author: Ashokkumar Sibiya, Selvaraju Vishnupriya, Vanajothi Ramar, Ramasamy Palaniappan, Vaseeharan Baskaralingam, and Sundaresan Bhavaniramya
Subjects: Drug, biology, SARS-CoV-2, business.industry, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, RNA, Outbreak, Genomics, General Medicine, biology.organism_classification, Antiviral Agents, Virology, Genome, COVID-19 Drug Treatment, Pandemic, Animals, Medicine, Coronaviridae, business, Pandemics, media_common
Abstract: Corona viruses are enveloped, single-stranded RNA (Ribonucleic acid) viruses, and they cause pandemic diseases having a devastating effect on both human healthcare and the global economy. To date, six corona viruses have been identified as pathogenic organisms, which are significantly responsible for the infection and cause severe respiratory diseases. Among them, the novel SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) caused a major outbreak of coronavirus diseases in 2019 (COVID-19). Coronaviridae family members can affect both humans and animals. In humans, coronaviruses cause a severe acute respiratory syndrome with mild to severe outcomes. Several structural and genomics aspects have been investigated, and the genome encodes about 30 proteins most of them with unknown function though they share remarkable sequence identity with other proteins. There are no potent drugs against SARS-CoV-2 and several trials are underway to investigate the possible therapeutic agents against viral infection. However, some of the antiviral drugs that have been investigated against SARS-CoV-2 are under clinical trials. In the current review, we comparatively emphasize the emergence and pathogenicity of the SARS-CoV-2 and their infection, and discuss the various putative drug targets of both viral and host receptors for developing effective vaccines and therapeutic combinations to overcome the viral outbreak.
Published: 2022
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2. The role of total alimentary limb length in Roux-en-Y gastric bypass: a systematic review

Author: Roc W. Bauman, Iain H. McKillop, Kyle J. Thompson, Abdelrahman Nimeri, Selwan Barbat, Alexander Abdurakhmanov, Lauren Poliakin, Alice Wang, Naresh Sundaresan, Keith S. Gersin, Vilok Vijayanagar, and Timothy S. Kuwada
Subjects: musculoskeletal diseases, medicine.medical_specialty, Ovid medline, Gastric bypass, Gastric Bypass, Protein-Energy Malnutrition, Weight loss, Weight Loss, medicine, Humans, Obesity, skin and connective tissue diseases, Alimentary limb, business.industry, Malnutrition, nutritional and metabolic diseases, medicine.disease, Roux-en-Y anastomosis, humanities, Limb length, Obesity, Morbid, Surgery, Search terms, medicine.symptom, business, human activities
Abstract: Roux-en-Y gastric bypass (RYGB) is an established surgical treatment for obesity. Variations in limb length during RYGB procedures have been investigated for optimizing weight loss while minimizing nutritional deficiencies. The role of the total alimentary limb length (TALL; Roux limb plus common channel [CC]), however, is poorly defined.Compare TALL in RYGB procedures for weight loss outcomes and malnutrition.Systematic review.Ovid Medline and PubMed databases were searched for entries between 1993 and 2020. Search terms included "gastric bypass" and "TALL." Two independent reviewers screened the results.A total of 21 studies measured TALL in RYGB. Of these, 4 of 6 reported a relationship between TALL and weight loss. Additionally, 11 studies reported that when TALL was ≤400 cm and CC200 cm, 3.4% to 63.6% of patients required limb lengthening for protein malnutrition.The majority of studies on RYGB do not report TALL length. There is some evidence that weight loss is affected by shortening TALL, while a TALL ≤400 cm with CC200 should be avoided due to severe protein malnutrition. More studies on the effect of TALL are needed.
Published: 2022
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3. Analysis on unsteady heat transfer and fluid flow through sensible heat storage system

Author: Sundaresan R, C. Sasikumar, C. Rajaganapathy, Radha Krishnan Beemaraj, and M. Nagaraja
Subjects: Materials science, business.industry, Computer data storage, Heat transfer, Fluid dynamics, Mechanics, Sensible heat, business
Published: 2022
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4. Sweetening Strategies: Prepared Foods' R&D Seminar presenters take on the challenges and solutions to successfully formulating foods that meet consumers' desires for lower sugar--and optimal taste

Author: Sundaresan, Kasi
Subjects: Cargill Inc., Convenience foods, Sugar industry, Agricultural processing industry, Nutritional requirements, Sugar, Business, Food and beverage industries
Abstract: Accelerating Sweet Success: Sweetener Innovations for Sugar Reduction Wade Schmelzer, principal food scientist; and Alan Skradis, technical services manager, Cargill Inc., presented their Prepared Foods' R&D Seminar on sweetener innovations [...]
Published: 2018

5. Multi-Centre, Multi-Vendor and Multi-Disease Cardiac Segmentation

Author: Campello, Victor M., Gkontra, Polyxeni, Izquierdo, Cristian, Martin-Isla, Carlos, Sojoudi, Alireza, Full, Peter M., Maier-Hein, Klaus, Zhang, Yao, He, Zhiqiang, Ma, Jun, Parreno, Mario, Albiol, Alberto, Kong, Fanwei, Shadden, Shawn C., Corral Acero, Jorge, Sundaresan, Vaanathi, Saber, Mina, Elattar, Mustafa, Li, Hongwei, Menze, Bjoern, Khader, Firas, Haarburger, Christoph, Scannell, Cian M., Veta, Mitko, Carscadden, Adam, Punithakumar, Kumaradevan, Liu, Xiao, Tsaftaris, Sotirios A., Huang, Xiaoqiong, Yang, Xin, Li, Lei, Zhuang, Xiahai, Viladés Medel, David, Descalzo, Martin, Guala, Andrea, Mura, Lucía La, Friedrich, Matthias G., Garg, Ria, Lebel, Julie, Henriques, Filipe., Karakas, Mahir, Cavus, Ersin, Petersen, Steffen E., Escalera, Sergio, Segui, Santi, Rodriguez-Palomares, Jose F.., Lekadir, Karim, Universitat Autònoma de Barcelona, Medical Image Analysis, and EAISI Health
Subjects: Computer science, Processament digital d'imatges, computer.software_genre, SDG 3 – Goede gezondheid en welzijn, Field (computer science), 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Resource (project management), Segmentation, Cardiac imaging, Image segmentation, domain adaption, Radiological and Ultrasound Technology, Heart, Benchmarking, Magnetic Resonance Imaging, Hospitals, Computer Science Applications, Generalizability, Domain adaption, Biomedical engineering, data augmentation, Data augmentation, Machine learning, 03 medical and health sciences, Magnetic resonance imaging, SDG 3 - Good Health and Well-being, Imatges per ressonància magnètica, Aprenentatge automàtic, Humans, Training, Generalizability theory, Electrical and Electronic Engineering, generalizability, business.industry, Deep learning, deep learning, Public dataset, public dataset, Cardiac Imaging Techniques, Cardiovascular magnetic resonance, Artificial intelligence, business, computer, Digital image processing, Software, Protocols
Abstract: The emergence of deep learning has considerably advanced the state-of-the-art in cardiac magnetic resonance (CMR) segmentation. Many techniques have been proposed over the last few years, bringing the accuracy of automated segmentation close to human performance. However, these models have been all too often trained and validated using cardiac imaging samples from single clinical centres or homogeneous imaging protocols. This has prevented the development and validation of models that are generalizable across different clinical centres, imaging conditions or scanner vendors. To promote further research and scientific benchmarking in the field of generalizable deep learning for cardiac segmentation, this paper presents the results of the Multi-Centre, Multi-Vendor and Multi-Disease Cardiac Segmentation (M&Ms) Challenge, which was recently organized as part of the MICCAI 2020 Conference. A total of 14 teams submitted different solutions to the problem, combining various baseline models, data augmentation strategies, and domain adaptation techniques. The obtained results indicate the importance of intensity-driven data augmentation, as well as the need for further research to improve generalizability towards unseen scanner vendors or new imaging protocols. Furthermore, we present a new resource of 375 heterogeneous CMR datasets acquired by using four different scanner vendors in six hospitals and three different countries (Spain, Canada and Germany), which we provide as open-access for the community to enable future research in the field.
Published: 2021

6. The longitudinal impact of division-wide implementation of an enhanced recovery after thoracic surgery programme

Author: Amanda M S Mattice, Sudhir Sundaresan, Alex Lee, Farid M. Shamji, Donna E. Maziak, Tim Ramsay, James Villeneuve, Sebastian Gilbert, Nazgol Seyednejad, Jamie C. Brehaut, Andrew J.E. Seely, Calvin Thompson, and Yaseen Al Lawati
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Longitudinal study, medicine.medical_treatment, Patient satisfaction, Quality of life, Patient experience, medicine, Humans, Longitudinal Studies, Prospective Studies, Adverse effect, Retrospective Studies, business.industry, Thoracic Surgery, General Medicine, Perioperative, Length of Stay, Chest tube, Cardiothoracic surgery, Quality of Life, Physical therapy, Surgery, Enhanced Recovery After Surgery, Cardiology and Cardiovascular Medicine, business
Abstract: OBJECTIVES Data regarding enhanced recovery after thoracic surgery (ERATS) are sparse and inconsistent. This study aims to evaluate the effects of implementing an enhanced ERATS programme on postoperative outcomes, patient experience and quality of life (QOL). METHODS We conducted a prospective, longitudinal study evaluating 9 months before (pre-ERATS) and 9 months after (post-ERATS) a 3-month implementation of an ERATS programme in a single academic tertiary care centre. All patients undergoing major thoracic surgeries were included. The primary outcomes included length of stay (LOS), adverse events (AEs), 6-min walk test scores at 4 weeks, 30-day emergency room visits (without admission) and 30-day readmissions. The process-of-care outcomes included time to ‘out-of-bed’, independent ambulation, successful fluid intake, last chest tube removal and removal of urinary catheter. Perioperative anaesthesia-related outcomes were examined as well as patient experience and QOL scores. RESULTS The pre-ERATS group (n = 352 patients) and post-ERATS group (n = 352) demonstrated no differences in demographics. Post-ERATS patients had improved LOS (4.7 vs 6.2 days, P CONCLUSIONS ERATS implementation was associated with improved LOS, expedited feeding, ambulation and chest tube removal, without increasing AEs or readmissions, while maintaining a high level of patient satisfaction and QOL.
Published: 2021
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7. Outcomes and Their State-level Variation in Patients Undergoing Surgery With Perioperative SARS-CoV-2 Infection in the USA

Author: Osaid, Alser, Ander Dorken Gallastegi, Anthony, Gebran, Kerry, Breen, Mohamad El Moheb, Apostolos, Gaitanidis, Leon, Naar, Brittany, Bankhead-Kendall, Hassan, Mashbari, Robert, D Sinyard, Lydia, R Maurer, Charu, Paranjape, George, C Velmahos, Dmitri, Nepogodiev, Aneel, Bhangu, Haytham M, A Kaafarani, Kwabena, Siaw-Acheampong, Leah, Argus, Daoud, Chaudhry, Brett, E Dawson, James, C Glasbey, Rohan, R Gujjuri, Conor, S Jones, Sivesh, K Kamarajah, Chetan, Khatri, James, M Keatley, Samuel, Lawday, Elizabeth, Li, Harvinder, Mann, Ella, J Marson, Kenneth, A Mclean, Maria, Picciochi, Elliott, H Taylor, Abhinav, Tiwari, Joana F, F Simoes, Isobel, M Trout, Mary, L Venn, Richard J, W Wilkin, Irida, Dajti, Arben, Gjata, Oussama, Kacimi, Luis, Boccalatte, Maria Marta Modolo, Daniel, Cox, Peter, Pockney, Philip, Townend, Felix, Aigner, Irmgard, Kronberger, Ahmed, Elgun, Amer, Alderazi, Kamral, Hossain, Greg, Padmore, Gabrielle, Vanramshorst, Ismail, Lawani, Duane, Wedderburn, Sonam, Dargay, Israël, Feraudy, Cerovac, Anis, Samir, Delibegovic, Alemayehu Ginbo Bedada, Gustavo, Ataide, Glauco, Baiocchi, Igor, Buarque, Muhammad, Gohar, Mihail, Slavchev, Jean Marie Vianney Butoyi, Chukwuemeka, Nwegbu, Arnav, Agarwal, Amanpreet, Brar, Janet, Martin, Maricarmen, Olivos, Dong-Lin, Ren, Wenhui, Lou, Jose, Calvache, Carlos Jose Perez Rivera, Ana Danic Hadzibegovic, Tomislav, Kopjar, Jakov, Mihanovic, Pablo, Avilés, Nikolaos, Gouvas, Jaroslav, Klat, René, Novysedlak, Nicolas, Amisi, Peter, Christensen, Alaa, El-Hussuna, Sylvia, Batista, Eddy, Lincango, Sameh, H Emile, Danilo Alfonso Arévalo Sandoval, Mengistu Gebreyohanes Mengesha, Samuel, Hailu, Hailu, Tamiru, Joonas, Kauppila, Johanna, Laukkarinen, Alexis, Arnaud, Roumanatou Bankole Sapin, Kebba, Marenah, Zaza, Demetrashvili, Andreas, A Schnitzbauer, Magdalena, Gruendl, Markus, Albertsmeiers, Hans, Lederhuber, Markus, Loffler, Bernard Ofori Appiah, Daniel, Acquah, Stephen, Tabiri, Symeon, Metallidis, Georgios, Tsoulfas, Maria Aguilera Lorena, Gustavo, Grecinos, Tamas, Mersich, Daniel, Wettstein, Atul, Suroy, Dhruv, Ghosh, Pranay, Pawar, Gabriele, Kembuan, Peiman, Brouk, Mohammad, Khosravi, Masoud, Mozafari, Ahmed, Adil, Helen, M Mohan, Oded, Zmora, Marco, Fiore, Gallo, G, Pata, Francesco, Gianluca, Pellino, Naoto, Kuroda, Sohei, Satoi, Yuki, Fujimoto, Faris, Ayasra, Mohammad, Chaar, Ildar, R Fakhradiyev, Intisar, Hisham, Jin-Young, Jang, Enver, Fekaj, Mohammad, Jamal, Anvar, Beisembaev, Muhammed, Elhadi, Aiste, Gulla, Luc, Samison, Jupsi, Neny, Palesa, Chisala, April, Roslani, Iran Irani Duran Sanchez, Laura Martinez Perez Maldonado, Antonio Ramos De La Medina, Jade, Nunez, Oumaima, Outani, Abd'Rashid, Nashidengo, Ashish Lal Shrestha, Rakesh, Shah, Pascal, Jonker, Schelto, Kruijff, Milou, Noltes, Pieter, Steinkamp, Willemijn van der Plas, Chris, Varghese, Deborah, Wright, Jorge, Neira, Adesoji, Ademuyiwa, Babatunde, Osinaike, Justina, Seyi-Olajide, Emmanuel, Williams, Sofija, Pejkova, Knut Magne Augestad, Kjetil, Soreide, Zainab Al Balushi, Ahmad, Qureshi, Raza, Sayyed, Mustafa Abu Mohsen Daraghmeh, Sadi, Abukhalaf, Moises, Cukier, Chris, Munguas, Hugo, Gomez, Sebastian, Shu, Ximena, Vasquez, Marie Dione Parreno-Sacdalan, Piotr, Major, José, Azevedo, Miguel, Cunha, Irene, Santos, Ahmad, Zarour, Eduard-Alexandru, Bonci, Ionut, Negoi, Sergey, Efetov, Andrey, Litvin, Faustin, Ntirenganya, Ehab, Alameer, Abdourahmane, Ndong, Dejan, Radenkovic, Ibrahim, Sesay, Frederick Koh Hong Xiang, Chew Min Hoe, James Ngu Chi Yong, Arpad, Panyko, Jurij, Kosir, Uros, Bele, Hassan, Ali, Rachel, Moore, Ncamsile, Nhlabathi, Ruth Blanco Colino, Ana Minaya Bravo, Umesh, Jayarajah, Dakshitha, Wickramasinghe, Mohammed, Elmujtaba, William, Jebril, Martin, Rutegård, Malin, Sund, Eleftherios, Gialamas, Karoline, Horisberger, Michel, Adamina, Muhammad, Alshaar, Abel, Huang, Ben, Mbwele, Varut, Lohsiriwat, Shane, Charles, Haithem, Jlassi, Arda, Isik, Sezai, Leventoğlu, Lekuya, Herve, Lekuya, Monka, Herman, Lule, Tom E, F Abbott, Ruth, Benson, Caruna, Ed, Sohini, Chakrabortee, Andreas, Demetriades, Anant, Desai, Thomas, D Drake, John, G Edwards, Jonathan, P Evans, Samuel, Ford, Christina, Fotopoulou, Ewen, Griffiths, Peter, Hutchinson, Michael, D Jenkinson, Tabassum, Khan, Stephen, Knight, Angelos, Kolias, Elaine, Leung, Siobhan, Mckay, Lisa, Norman, Riinu, Ots, Vidya, Raghavan, Keith, Roberts, Andrew, Schache, Richard, Shaw, Katie, Shaw, Neil, Smart, Grant, Stewart, Sudha, Sundar, Dale, Vimalchandran, Naomi, Wright, Slava, Kopetskiy, Sattar, Alshryda, Ian, Ganly, Haytham, Kaafarani, Brittany, Kendall, Fernando, Bonilla, Hamza Al Naggar, Mayaba, Maimbo, Dennis, Mazingi, J Wong, J, Napolitano, L, Hemmila, M, Amin, D, Abramowicz, S, M Roser, S, A Olson, K, Riley, C, Heron, C, Cardenas, T, Leede, E, Thornhill, M, B Haynes, A, Mcelhinney, K, Roward, S, D Trust, M, E Hill, C, G Teixeira, P, Etchill, E, Stevens, K, R Ladd, M, Long, C, Rose, J, Kent, A, Yesantharao, P, Vervoort, D, Jenny, H, Gabre-Kidan, A, Margalit, A, Tsai, L, Malapati, H, Yesantharao, L, Abdou, H, Diaz, J, Richmond, M, Clark, J, O'Meara, L, Hanna, N, Ying, Y, Fleming, J, Ovaitt, A, Gigliotti, J, Fuson, A, Cooper, Z, Salim, A, A Hirji, S, Brown, A, Chung, C, Hansen, L, U Okafor, B, Roxo, V, P Raut, C, S Jolissaint, J, A Mahvi, D, Kaafarani, H, Breen, K, Bankhead-Kendall, B, Alser, O, Mashbari, H, Velmahos, G, R Maurer, L, M El Moheb, Gaitanidis, A, Naar, L, A Christensen, M, Kapoen, C, Langeveld, K, M El Hechi, Mokhtari, A, H Haqqani, M, T Drake, F, Goldenberg-Sandau, A, Galbreath, B, Reinke, C, Ross, S, Thompson, K, Manning, D, Perkins, R, Eriksson, E, Evans, H, Masrur, M, Giulianotti, P, Benedetti, E, Chang, G, Ourieff, J, Dehart, D, Dorafshar, A, Price, T, R Bhama, A, Torquati, A, Cherullo, E, Kennedy, R, Myers, J, Rubin, K, S Ban, V, G Aoun, S, H Batjer, H, Caruso, J, Carmichael, H, G Velopulos, C, L Wright, F, Urban, S, C McIntyre Jr, R, J Schroeppel, T, A Hennessy, E, Dunn, J, Zier, L, Burlew, C, Coleman, J, P Colling, K, Hall, B, E Rice, H, S Hwang, E, A Olson, S, Moris, D, Verma, R, Hassan, R, Volpe, A, Merola, S, A O'Banion, L, Lilienstein, J, Dirks, R, Marwan, H, Almasri, M, Kulkarni, G, Mehdi, M, Abouassi, A, Abdallah, M, M San Andrés, Eid, J, Aigbivbalu, E, Sundaresan, J, George, B, Ssentongo, A, Ssentongo, P, S Oh, J, Hazelton, J, Maines, J, Gusani, N, Garner, M, Horvath, S, Zheng, F, Ujiki, M, Kinnaman, G, Meagher, A, Sharma, I, Holler, E, Mckenzie, K, Chan, J, Fretwell, K, W Nugent 3rd, Khalil, A, Chen, D, Post, N, Rostkowski, T, Brahmbhatt, D, Huynh, K, L Hibbard, M, Schellenberg, M, R C, G Martin, Bhutiani, N, Giorgakis, E, Laryea, J, Bhavaraju, A, Sexton, K, Roberts, M, Kost, M, Kimbrough, M, Burdine, L, Kalkwarf, K, Robertson, R, Gosain, A, Camp, L, Lewit, R, P Kronenfeld, J, Urrechaga, E, Goel, N, Rattan, R, Hart, V, Allen, M, Gilna, G, Cioci, A, Ruiz, G, Rakoczy, K, Pavlis, W, Saberi, R, Morris, R, S Karam, B, C E, M Brathwaite, Liu, H, Petrone, P, Hakmi, H, H Sohail, A, Baltazar, G, Heckburn, R, M Nygaard, R, T Colonna, E, W Endorf, F, J Hill, M, Maiga, A, Dennis, B, H Levin, J, Lallemand, M, Choron, R, Peck, G, Soliman, F, Rehman, S, Glass, N, Juthani, B, Deisher, D, M Ruzgar, N, J Ullrich, S, Sion, M, Paranjape, C, R Kar, A, Gillezeau, C, Rapp, J, Taioli, E, A Miles, B, Alpert, N, Podolsky, D, L Coleman, N, P Callahan, M, Ganly, I, Brown, L, J R, T Monson, Dehal, A, Abbas, A, Soliman, A, Kim, B, Jones, C, D Dauer, M, Renza-Stingone, E, Hernandez, E, Gokcen, E, Kropf, E, Sufrin, H, Hirsch, H, Ross, H, Engel, J, Sewards, J, Poggio, J, Sanserino, K, Rae, L, Philp, M, Metro, M, Mcnelis, P, Petrov, R, Pazionis, T, Till, B, Lamm, R, J Rios-Diaz, A, Palazzo, F, Rosengart, M, Nicholson, K, M Carrick, M, Rodkey, K, Suri, A, Callcut, R, Nicholson, S, Talathoti, N, Klaristenfeld, D, Biffl, W, Marsh, C, Schaffer, K, E Berndtson, A, Averbach, S, Curry, T, Kwan-Feinberg, R, Consorti, E, Gonzalez, R, Grolman, R, Liu, T, Merzlikin, O, K Abel, M, Ozgediz, D, Boeck, M, Z Kornblith, L, Nunez-Garcia, B, Robinson, B, Park, P, F Utria, A, E Rice-Townsend, S, Javid, P, Hauptman, J, Kieran, K, Nehra, D, Walters, A, Cuschieri, J, H Davidson, G, Nunez, J, Cosker, R, Eckhouse, S, Choudhry, A, Marx, W, Jamil, T, Seegert, S, Al-Embideen, S, Quintana, M, Jackson, H, D Wexner, S, Kent, I, N Martins, P, Xiao, Liu, and Alistair, Denniston
Subjects: Male, medicine.medical_specialty, Revised Cardiac Risk Index, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pulmonary complications, Malignancy, Time-to-Treatment, Postoperative Complications, Sex Factors, Risk Factors, medicine, COVID-19, COVIDSurg, elective surgery, emergency surgery, mortality, pulmonary complications, Humans, In patient, Prospective Studies, emergency surgery, Elective surgery, Aged, Respiratory Distress Syndrome, SARS-CoV-2, business.industry, Pulmonary Complication, Age Factors, COVID-19, Pneumonia, Perioperative, Middle Aged, COVIDSurg, elective surgery, mortality, medicine.disease, United States, Surgery, Multicenter study, Elective Surgical Procedures, Female, business
Abstract: Objective To report the 30-day outcomes of patients with perioperative SARS-CoV-2 infection undergoing surgery in the USA. Summary background data Uncertainty regarding the postoperative risks of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists. Methods As part of the COVIDSurg multicenter study, all patients aged ≥17 years undergoing surgery between January 1 and June 30, 2020 with perioperative SARS-CoV-2 infection in 70 hospitals across 27 states were included. The primary outcomes were 30-day mortality and pulmonary complications. Multivariable analyses (adjusting for demographics, comorbidities, and procedure characteristics) were performed to identify predictors of mortality. Results A total of 1,581 patients were included; more than half of them were males (n= 822, 52.0%) and older than 50 years (n=835, 52.8%). Most procedures (n=1,261, 79.8%) were emergent, and laparotomies (n= 538, 34.1%). The mortality and pulmonary complication rates were 11.0 and 39.5%, respectively. Independent predictors of mortality included age ≥70 years (OR 2.46, 95% CI [1.65-3.69]), male sex (2.26 [1.53-3.35]), ASA grades 3-5 (3.08 [1.60-5.95]), emergent surgery (2.44 [1.31-4.54]), malignancy (2.97 [1.58-5.57]), respiratory comorbidities (2.08 [1.30-3.32]), and higher Revised Cardiac Risk Index (1.20 [1.02-1.41]). While statewide elective cancelation orders were not associated with a lower mortality, a sub-analysis showed it to be associated with lower mortality in those who underwent elective surgery (0.14 [0.03-0.61]). Conclusions Patients with perioperative SARS-CoV-2 infection have a significantly high risk for postoperative complications, especially elderly males. Postponing elective surgery and adopting non-operative management, when reasonable, should be considered in the USA during the pandemic peaks.
Published: 2021
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8. Clinician perspectives on the factors influencing prognostic stratification by the American Joint Commission on Cancer Head and Neck Cutaneous Squamous Cell Carcinoma Staging

Author: Jonathan R. Clark, Sandro V. Porceddu, Carsten E. Palme, Ruta Gupta, Francesca Watts, and Purnima Sundaresan
Subjects: Oncology, medicine.medical_specialty, Skin Neoplasms, Cutaneous squamous cell carcinoma, medicine.medical_treatment, 030230 surgery, Prognostic stratification, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Head and neck, Societies, Medical, Neoplasm Staging, Cancer staging, Squamous Cell Carcinoma of Head and Neck, business.industry, Extranodal Extension, Head and neck cancer, Cancer, Immunosuppression, Prognosis, medicine.disease, United States, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Surgery, business
Abstract: Background The eighth edition of the American Joint Committee on Cancer Staging Manual includes a staging system for head and neck cutaneous squamous cell carcinoma for the first time. The pN categories for head and neck cutaneous squamous cell carcinoma and mucosal squamous cell carcinoma are identical, despite the vastly different biological behavior of these diseases. This study aimed to survey head and neck cancer specialists’ views regarding the clinical utility of the American Joint Committee on Cancer Staging Manual for head and neck cutaneous squamous cell carcinoma and to identify avenues for improvement. Design An electronic survey of 19 questions relating to the prognostic utility of the staging system was designed based on the findings of a literature review. The survey was distributed internationally to specialists managing head and neck cutaneous squamous cell carcinoma. Results Literature review identified 9 articles describing primary research relevant to the performance of the American Joint Committee on Cancer Staging Manual for head and neck cutaneous squamous cell carcinoma, which recognized a lack of homogeneity, monotonicity, and distinctiveness in the pN staging system. One hundred and five survey responses were received: 71% indicated that mucosal and head and neck cutaneous squamous cell carcinoma require different nodal staging categories; 63% indicated that immunosuppression should be included in the staging system; 70% thought that soft tissue metastases portend a worse prognosis compared with extranodal extension; 38% almost never saw pN3a tumors; and 40% felt that the N stage is a poor predictor of survival. Conclusion The views of head and neck cancer specialists across disciplines and countries align with evidence suggesting that head and neck cutaneous squamous cell carcinoma merits a staging system distinct from mucosal squamous cell carcinoma, that immunosuppression should be considered in prognostication, and that the use of extranodal extension should be modified.
Published: 2021
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9. Can adjuvant pelvic radiation therapy after local excision or polypectomy for T1 and T2 rectal cancer offer an alternative option to radical surgery?

Author: Puma Sundaresan, Drew Latty, Jayasingham Jayamohan, Nimalan Pathma-Nathan, Mark Wong, Toufic El-Khoury, Adnan Nagrial, Sapna Marcus, and Carmen Swanton
Subjects: Transanal Endoscopic Microsurgery, medicine.medical_specialty, medicine.medical_treatment, R895-920, Endoscopic mucosal resection, Case Report, Adjuvant therapy, Transanal minimally invasive surgery, Medical physics. Medical radiology. Nuclear medicine, Rectal Adenocarcinoma, Medicine, Radiology, Nuclear Medicine and imaging, Radical surgery, Rectal cancer, RC254-282, business.industry, Abdominoperineal resection, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Total mesorectal excision, Polypectomy, Surgery, Radiation therapy, Oncology, business
Abstract: Highlights • Adjuvant radiation therapy post local excision o f T1/T2 rectal cancer offers good disease control. • There were no locoregional recurrences at median follow up of 51 months. • This approach was well tolerated. • This approach may offer an alternative to TME surgery., Purpose To determine outcomes after adjuvant pelvic local radiation therapy (RT) +/− concurrent chemotherapy for T1 and T2 rectal carcinomas treated with local excision or polypectomy. Methods We retrospectively identified adult patients with histologically proven T1 and T2 rectal adenocarcinoma, diagnosed incidentally at time of local excision or polypectomy between 01 January 2007 and 31 December 2019, and appropriately staged to confirm N0 M0 status. Patients were excluded if they had recurrent cancer or had received total mesorectal excision (TME): anterior resection (AR) or abdominoperineal resection (APR). Patient, tumour and treatment factors, together with disease and toxicity outcomes were collected from institutional medical records, correspondence and investigation reports. Descriptive statistical analyses were employed. The primary endpoint was loco-regional control and secondary endpoints were treatment-related toxicity, disease free survival, overall survival and rate of surgical salvage for pelvic recurrence. Results The median age of the 15 eligible patients was 73 (range 49–82 years). There were 9 men (60%) and 6 women (40%). The majority had T1 disease (80%) and most had received endomucosal resection (80%). All patients received 43-52Gy (EQD2) to the primary and 43-48Gy (EQD2) to the pelvis with 46.6% receiving concurrent chemotherapy (infusional 5-FU or oral capecitabine). At median follow up of 51 months, there were no local or regional recurrences. One patient experienced an isolated distant relapse at 48 months without any locoregional recurrence. Conclusion Our findings demonstrate good locoregional disease control with the use of adjuvant pelvic RT for T1 and T2 rectal adenocarcinoma initially treated with polypectomy or local (non-oncological) excision. These findings indicate that adjuvant pelvic RT may provide an alternative to TME surgery in patients with incidentally detected early rectal cancers.
Published: 2021

10. Understanding the performance of a pan-African intervention to reduce postoperative mortality: a mixed-methods process evaluation of the ASOS-2 trial

Author: Nicola Vickery, Timothy Stephens, Leon du Toit, Dawid van Straaten, Rupert Pearse, Alexandra Torborg, Lucy Rolt, Mariechen Puchert, Graham Martin, Bruce Biccard, Bruce M. Biccard, Maia Lesosky, Tim Stephens, Landon Myer, Agya BA. Prempeh, Hyla-Louise Kluyts, Akinyinka Omigbodun, Adesoji Ademuyiwa, Muhammed Elhadi, Mohamed Elfagieh, Bernard Mbwele, Mpoki Ulisubisya, Lazaro Mboma, Daniel Z. Ashebir, Mahlet Tesfaye Bahta, Mohammed Hassen, Mikiyas Teferi, Yakob Seman, Eugene Zoumenou, Adam Hewitt-Smith, Janat Tumukunde, Dolly Munlemvo, Atilio Morais, Apollo Basenero, Pisirai Ndarukwa, Nazinigouba Ouerdraogo, Maman Sani Chaibou, Mohyeddine Zarouf, Ahmed Rhassane El Adib, Veekash Gobin, Zimogo Sanogo, Youssouf Coulibaly, Zipporah Ngumi, Tarig Fadalla, Cynthia Iradukunda, Vénérand Barendegere, Isaac O. Smalle, Mustapha Bittaye, Ahmadou Lamin Samateh, Mahmoud Elfiky, Maher Fawzy, Wakisa Mulwafu, Vanessa Msosa, Lygia Lopes, Akwasi Antwi-Kusi, Hamza D. Sama, Patrice Forget, Rupert M. Pearse, Marichen Puchert, Kris Schwebler, Freddy Kabambi, Tebogo Mabotja, Leandys Cobas, Albino Freitas, Maria Antunes, Bartolomeu Cabo, Domingos Paulo, Carlos Camongua, Yvette Avognon, Osseni Marcos, Raymond Kintomonho, Onesime Demahou, Gisèle Hounsa, Hugues Chobli, Elie Fassinou, Aurore Zoglobossou, Blaise Tchaou, Charles Tchegnonsi, Fifame Amadji, Francine Bossa, Ernest Ahounou, Djima Alao, Roushdane Odérémi, Afissatou Montairou, Oswald Gbehade, Romaric Tobome, Adam Boukari, Patrick Bakantieba, Arouna Sambo, Fanou Lionelle, Nounagnon Gilbert, Julien Attinon, Roger Klikpezo, Aumar Dadjo, Dénis Fanou, Gilberte Hounkpe, Bachabi Fafana, Néné Nguilu, Bodourin Dossou-Yovo, Chantal Segla, Mohamed Toko, Evelyne Gnele-Dedewanou, Michel Noukounwoui, Ethienne Yado, Timothé Gouroubéra, Valéry Adjignon, Serge Mewanou, Aïcha Tchomgang, Urielle Agossou, Fernand Soton, Charbel Azanlin, Lidwine Zomahoun, Rawéléguinbasba Armel Flavien Kabore, Salam Savadogo, Fatou Fleur Rosine Sanou, Farid Belém, Victoria Hien, Cheik Tidiane Hafid W. Bougouma, Sie Ahmed Ouattara, Mariam Bambara Kabore, Ouedraogo Nazinigouba, Papougnezambo Bonkoungou, Martin Lankoandé, Mireille Traoré, Patrick Sawadogo, Inès Wenmenga, Boureima Kinda, André Simporé, Christian Sapo, Salah Idriss Traore, Haoua Dipama, Lydie WR. Kaboré, Salifou Napon, Télesphore G. Kaboré, Arouna Louré, Pélagie PP. Tondé, Christian Zoundi, Martin Lankoande, Harouna Sanou, Remy Ndikumana, Carlos Nsengiyumva, Gregory Sund, Alliance Niyukuri, Axel Kwizera, Jean-Claude Niyondiko, Adolphe Manzanza Kilembe, Jean Pierre Mwema Ilunga, Nehema Hailemariam Sarah, Gabriel Mubobo Makeya, Idesbald Mwebe Mwepu, Ted Botawaosenge Likongo, Richard Kapela Mvwala, Raphael Nzau Kapend Mubunda, Noellie Kanka Mukuna, Julie Djondo Pembe, Nicolas Lumuanga Ndaye, Eric Bibonge Amisi, Mike Ilunga Madika, Joe Kembo Lungela, Didier Ndonda Mayemba, Philomene Mamba Diyoyo, Alex Mbo Ngalala, Martin Mamba Mukenga, Patricia Tito Kabuni, Dany Bolimo Mpoto, Herve Inesnku Mole, Louise Keby, Oria Andavo Buti, Anselme Phaka, Belinda Mayenge, Jean Jeacques Kabuley Kalongo, Timothe Kemfuni Mawisa, Rodrigue Tondo Ngwizani, Kuyala Leya, Dieudonne Kisile Sanduku, Timothe Nkemfuni Mawisa, Coco Nseke Mfumu, Mbuta Bolenge, Desire Kinzenzengu Kabuce, Patrick Kintieti, Amelia Mbuluku, Vicky Mahuwa, Tharcice Khonde Mabiala, Guilain Ngoy, Patrick Boloko, Nono Mazangama Mvwama, Jose Kengbanda, Pitchou Mushimbonga, Blaise Kuhapala, Nzosani Marcel, Kienze Guylain, Gerard Mboma, Sandra Zalambo Sagboze, Michel Muteya Manika, Jean Pierre Mumbere Kigayi, Roger Mukanire Cishugi, Placide Buhendwa Mugisho, Roger Baguma, Moïse Kongolo, Michel Mandungu Mbayabu, Crispin Mukendi Muamba, Edmond Banema Kapinga, Vasco Ngolela Kapinga, Guylain Tshimanga Nsumpi, Patrick Kanda Odia, Salomon Bingidimi, Gilbert Kpengbemale, Desire Hubert Bofunga Bosonga Imposo, Patricia Matondo, Servet Lelo, Jeremie Kalambayi, Mohamed Abdel-Ghaffar, Abdelrahman Soliman, Mostafa Abdelrahman, Sameh Shehata, Alia Rabee, Mohamed Abou Heba, Mohamed Rabei Abdelfattah, Tamer Ahmed Maher Ghoniem, Sherif M.K. Shehata, Mohamed Lotfy, Ahmed ElHaddad, Bereket Gebremeskel, Girmay Fisseha, Mebrahtu Abay, Degena Bahrey, Assefa Hika, Abdurezak Ali, Kindie Moges, Jemal Ahmed, Desalegn Abdisa, Abebe Megersa, Wendwosen Abayne, Haftom Berhane, Reiye Esayas, Fitsum Kifle, Kokeb Desita, Abebe Addise, Dagim Shimelash, Shitalem Tadesse, Bezaye Zemedkun, Peniel Kenna, Ayenew Yirdie, Abinet Sisay, Tebikew Gashu, Fassil Mihretu, Yesuf Ahmed, Bekele Debebe, Abdureuf Misgea, Amare Agmas, Rahel Assefa, Abdurahman Gelmo, Seifu Alemu, Brook Damtachew, Merid Mersha, Yaekob Chemere, Samuel Fekadu, Sintayehu Regasa, Bonsa Sileshi, Desalegn Wosen, Rebira Adamu, Gersam Mulugeta, Teshome Bacha, Zewude Gudisa, Kebebe Bekele, Alelign Tasew, Habtamu Gezahegn, Daniel Atlaw, Damtew Solomon, Habtemariam Gebresillasie, Girmaye Tesfaye, Negussie Sarbecha, Biniyam Sahiledengle, Kenbon Seyoum, Gemechu Ganfure, Yohannes Tekalegn, Gosa Tesfaye, Temesgen Ayichew, Shibiru Sendaba, Musefa Redwan, Eyasu Muse, Girma Nina, Bizuneh Sime, Addisalem Tadege, Anbesse Jima, Nugusu Ayalew, Dagmawi Workneh, Daniel Teferi, Momodou T. Nyassi, Landing N. Sanyang, Omar Jallow, Abdoulie Keita, Kitabu Jammeh, Charles Roberts, Patrick Idoko, Kebba Marenah, Masirending Njie, Musa Marena, Karamba Suwareh, Simon Boissey, Fatoumatta Jarjusey, Awa Jah, Awa Sanyang, Dado Jabbi, Kajali Camara, Armando Correa, John Jabang, Lamin Jaiteh, Lamin Dampha, Aminata Manneh, Baboucarr Sowe, Abdoulie Bah, Edrisa Jawo, Victoria Okoje, Momodou Baro, Yaya Bah, Mustapha Njie, Sainabou Mbowe, Ebrima Kanteh, Sarjo Ceesay, Alagie Manneh, Evans Atito-Narh, Adwoa Wilson, Romeo Hussey, Emmanuel Okine, Jemima Kwarteng, Ridge Ntiamoah, Samuel Dadzie, Mark Aseti, Naa Sowah, Akosua Appiah, Charles Bankah, Patrick Mburugu, Thomas Chokwe, Patrick Olang, Vernon Gacii, Susane Nabulindo, Antony Gatheru, Timothy Mwiti, Caroline Mwangi, Julius Muriithi, Daniel Ojuka, Omondi Ogutu, Evans Masitara, Mohamed Chaudhry, Reuben Kamundi, Annmarie Kangangi, Thomas Massaquoi, Stephen Takow, Felister Moraa, Aziz Munubi, Moses Kimani, Adili Wobenjo, Linda Nguu, Vincent Omeddo, Rose Malaba, Ambrose Nabwana, Anita Mwancha, Alexandria Mugaa, John Wamwaki, Joyce Chege, Seymour Sinari, Andrew Ndonga, Rose Shitsinzi, Walter Akello, Winfred Kimani, Elisha Kirwa, Seno Saruni, Andrew Wainaina, Ernest Nshom, Aidah Kenseko, Kizito Shisanya, Purity Wanjiru, Julliah Cherotich, Judy Kimutai, Benson Wahome, Grace Wangui, Dennis Wamalwa, Stephen Mwangi, John Chege, Tabitha Wanjiku, Carolyne Njoki, Wachira Waititu, Conrad Ambani, Samuel Murimi, Sharon Waithira, Nilson Mouti, Collins Kibet, John Kibet, Virginia Sokobe, Beatrice Jeymah, Antony Kamadi, Faith Gichuri, Steve Moses, David Wasike, Favours Adeya, Caesar Bitta, Stephen Ogendo, Killian Kariuki, Hdaya BenAbdalla, Taha Suliaman, Fatima Ali Abokhzam, Mohaned Isa, Mohammed Huwaysh, Asma Bourawi, Kais Alzubaidy, Mohammed Albaraesi, Sumayyah Bahroun, Abdulmueti Alhadi, Ahmed Msherghi, Amira Mohamed, Ala Khaled, Nouran Aljadi, Elham Bareig, Khaled Elgazwi, Adel Elgazwi, Ibrahim El-busife, Safa Owhida, Almahdi Eltwati, Samah Elakeili, Taha Abubaker, Fatima Elkhfeefi, Soha Younis Hasan, Amal Alttaira, Imbarkah Elmraied, Rim Wishah, Omar Abugassa, Hazem Ahmed, Amera Ellafi, Shoukrie Shoukrie, Nawal Aldokali, Aws ElGammudi, Akram Alkaseek, Hoda Elhaddad, Ayyah Alqaarh, Ahlam Brish, Malek Abudsnnuga, Salsabil Albuaishi, Mohammed Albashri, Marwa Morgom, Mohammed Alawami, Eman Shawesh, Abdullah Almabrouk, Moaz Alwarfalli, Nagia Abeid, Anis Buzreg, Ans Malek, Ameerah Abayu, Butaina Abdulhafith, Wedad Abouruwes, Marim Albakuri, Sabria Almuammari, Esam Alsaghair, Fatheia Alreshi, Hassan Badi, Rabiee Alfetoey, Naji Zubia, Bushray Almiqlash, Abdulsalam Alshuhoumi, Rayet Al-islam Ben Jouira, Amaal Dier, Essra Gebril, Mohammed Abdelkabir, Sana Moussa, Marwa Alfitori, Mabroukah Azbeda, Hajar Alamin, Ejmeya Barka, Omlsaad Mosbah, Rema Abdasalam, Miftah Hiyoum, Maryam Abd allateef, Ibrahim Altomi, Mahdi Alsakloul, Ekhlas Karami, Munyah Alriqeeq, Mabruka Omar, Ashraf Samer, Aml Aemeesh, Ahmad Bouhuwaish, Ahmed Elusta, Sultan Ahmeed, Wesal AlFighi Hassan, Mouadah Ali Altayr, Mohamed Addalla, Abrar Geddeda, Kheria Khoja, Doaa Alhaj, Muaad Etturki, Ahmed Elhadi, Ibrahim Ellojli, Anshirah Shuwayyah, Ahmed Elfaghih, Malak Alduwayb, Mohamed Aleiyan, Wedad Aboubreeq, Soliman Alkassem, Sami Ashour, Hayat Ben Hasan, Najat Ben Hasan, Ali Yahya, Palesa Chisala, Edward Kommwa, Lusayo Simwinga, Agness Chalira, Precious Kachitsa, Onias Mtalimanja, Drissa Traoré, Moussa Sissoko, Moussa Camara, Adama Koita, Sekou Koumaré, Omar Sacko, Mahamadou Coulibaly, Lamine Soumaré, Soumaïla Keita, Sidiki Keita, Hamadoun Dicko, Boubacar Diallo, Boureima Bengaly, Mohamed Keita, Siaka Diallo, Drissa Ouattara, Nouhoun Ongoiba, Seydina Beye, Honoré Berthe, Mamadou Diakite, Mamadou Sima, Adégné Togo, Bakary Dembele, Djibo Diango, Moussa Samake, Youssouf Traoré, Louis Traoré, Ongoïba Oumar, Sogoba Gaoussou, Issaga Traoré, Sidy Sangaré, Doua Kanté, Lassana Cissé, Thiam Souleymane, Keita Koniba, Sundaresan Maiyalagan, Julien Chong, Adil Mohit, Khushyant Mungar, Shankaran Vinayagam, Kevin Ramlochun, Jamie Sim, Desai Sneha, Vishaal Kissoon, Yan Tseung, Mohamed Aboobakar, Nitish Fokeerah, Ravi Ramsewak, Jayprakash Gopall, Meetheelesh Abeeluck, Varun Seewoo, Divyanand Jankee, Ashveen Puryag, Senthil Beemadoo, Yashraj Deenoo, Abhisek Goureah, Munawwara Makoon, Hemanshu Rambojan, Beeharry Shanjugsingh, Kevin Viraswami, Shehzaad Joomye, Ashwant Bhugwandass, Bibi Deelawar, Vakil Leelodharry, Luckshmanraj Mungur, Sajid Aungraheeta, Sirsingh Bhajoo, Manpreet Rajcoomar, Rishi Seetaram, Subha Gaya, Gini Batra, Yoshvin Sunnassee, Shailendra Petkar, Sbai Hicham, Labib Smail, Ait Laalim Said, Motaai Youssef, Mouhssine Doumiri, Mustapha Alilou, Nora Farnaoui, Mustapha Bensghir, Abdelghafour Elkoundi, Abdelhamid Jaafari, Abderhmann Elwali, Mohammed Meziane, Walid Atmani, Houssam Rebahi, Hajar Chichou, Safae Zarouf, Abderraouf Soummani, Abou Elhassan Taoufik, Meryem Essafti, Aminata Oumou Traoré, Hamzaoui Hamza, Adnane Berdai, El allani Linda, Salhi Oussama, Nelson Mucopo, Machado Banze, Mouzinho Saide, Tomas Sitoi, Artur Machava, Antonio Carlos, Amilton Guidione, Antonio Saide de Carvalho, Natacha Gemo, Samiro Sema Camal, Arsénio Cuna, Ornelos Madeira, Ladino Assuade, Dercio Amde Fernandes, Dulce Alexandre Machavae Fernandes, Mandua Sebastião, Bernard Sikombe, Matti Kandjimi, Ayoub Shekimweri, Diana Shilomboleni, Mbaundju Kandjii, Leonard Kabongo, Cholastic Hangero, Ike Ndjoze, Ruben Nailonga, Immanuel Uukonga, Uutoni Nakanyala, Lavinia Johannes, Adrian Haruzuvi, Chris Terblanche, Natangwe Shimenda, Delwina Katjipu, Hilma Shalimba, Juliah Kaweendwa, Ali Mbuyi, John Oyedele, Mapumba Mulolo, Peter Njuki, Mutombo Ndaie, Akutu Munyika, Hilma Katangolo, David Tjiyokola, Tawanda Mhene, Archbald Masiambiri, Paidamoyo Mandudzo, Sandra Kapepiso, Haziel Mavesere, Cedia Tjihoto, Daylight Manyere, Charlotte Kauraisa, Learnmore Garanowako, Michael Tune, William DeKlerk, Benvenue Ndolo, Maria Angula, Ndapewoshali Hishekwa, Elizabeth Nandjendja, Elsabe Tsauses, Eunice Mouton, Kudzai Katandawa, Sophia Bruwer, Jaydee Van Staden, Beata Siteketa, Beata Kaholongo, Martha Ntinda, Pueya Nashidengo, Johanna Kandjumbwa, Lahia Lipumbu, Moussa Sirfi, Fouma Djibo, Moutari Mahaman, Abdoulaye Mahaman Bachir, Maikassoua Mamane, Adakal Ousseini, Maman Noury Hamissou Souley, Rabo Oumarou, Rekia Idrissa, Moussa Ichaou, Amina Saley, Abdoulay Seyni, Sahabi Amadou, Mahamane Sani Mahamane Laminou, Issoufou Moustapha Camara, Moussa Gagara, Hadjara Rabiou Daddy, Harissou Adamou, Ibrahim Amadou Magagi, Oumarou Habou, Sabo Ramatou, Saidu Kadas, Rabiu Mohammed, Abubakar Ballah, Tella Olalekan, Kefas Bwala, Mohammed Adamu, Adamu Isa, Ademola Adeyeye, Samuel Fayose, Akinola Akinmade, Taiwo Ajayi, Elizabeth Nwasor, Saidu Yakubu, Euphemia Ugwu, George Mukoro, Muhammed Ahmed, Gideon Akafa, Ahmad Lawal, Daniel Nwoye, Michael Odigbo, Zulaihatu Sarkin-Pawa, Tunde Sholadoye, Benjamin Fomete, Hamisu Yakubu, Abdulkadir Kabiru, Samaila Timothy, Ali Yusuf, Tasiu Saadu, Babangida Mohammed, Abdulghaffar Yunus, Ganiyat Olagunju, Muhammad Aminu, Mohammad Idris, Musliu Tolani, Nasiru Dalhat, Samuel Gana, Talent Adike, Lofty-John Anyanwu, Abdurrahman Sheshe, Sani Aji, Mamuda Atiku, Raphael Attah, Abubakar Muhammed, Rasaki Oseni, Halima Salisu-Kabara, Benjamin Nkemjika, Omotayo Salami, Adekunle Akadri, Bukola Olayinka, Clement Onuoha, Umar Usman Jamaare, Auwalu Saminu Jibrin, Sani Giade Abdullahi, Ibrahim Ishaku, Adenike Odewabi, John Bamigboye, Oladapo Kuforiji, Chidiebere Ogo, Stella Ogunmuyiwa, Abdussemee Abdurrazzaaq, Adebayo Tanimola, Michael Adeyanju, Oluwatimilehin Andero, Temitope Ojo, Olusi Adedotun, Gbadamosi Kehinde, Jimoh Buraimoh, Kabiru Muhammad, Sophia Baidoo, Patrick Okoli, Azeez Adigun, Ekene Ezeonye, Kabir Isa, Yetunde Aremu-Kasumu, Kamil Shoretire, Peter Enesi, Amechi Ezike, Olatunde Olawoye, Emmanuel Ugwu, Christopher Ukah, Abolade Olugbenga, Nwachukwu Chidiebere, Nasiru Abdulraman, Adebiyi Olusegun, Alisa Halisa, Semiat Yusuf, Jamila Salisu, Chidiebube Okoro, Abdul Suleiman, Fabian Onowighose, Aliyu Farinyaro, Suleiman Baba, Umar Abdulmajid, Aisha Abdurrahman, Ogochukwu Obi, Olatunde Alabi, William Adeyemi, Jelili Salau, Jones Taiwo, Nnaemeka Nwafulume, Taiye Ibiyeye, Edith Agu, Ayodeji Danboy, James Abdulazeez, Christopher Ekwunife, Chimaobi Nnaji, Chigozirim Onyekpere, Amara Arunsi, Jude Egwim, Obianuju Nwana, Nnabuike Ojiegbe, Charles Mbamba, Paul Ngwu, Frank Imahigbe, Emmanuel Okoroji, Iloh Ikenna, Abdulrahman Mohammed, Adebayo Adeniyi, Toluwalope Ariyo, Olajide Gabriel, Tesleem Orewole, Salawu Idris, Idowu Adebara, Abiodun Okunlola, Akinwale Akinbade, Oluwasesan Afolabi, Adewumi Bakare, Olabisi Adeyemo, Benjamin Ugwu, Samuel Nuhu, Henry Embu, Erdoo Isamade, Chinedu Obikili, Amaka Ocheke, Solomon Peter, Donald Orshio, Peter Onuminya, Jack Okopi, Olufemi Bankole, Bosede Afolabi, Dapo Osinowo, Ayodeji Oluwole, Muyiwa Rotimi, Ibironke Desalu, Rufus Ojewola, Bolaji Mofikoya, Kola Owonikoko, Adeolu Adeoye, Temidayo Bobo, Taiwo Akinloye, David Ama, Ebere Okoronkwo, Muhammad Mahmud, Jamiu Adebiyi, Temitope Babalola, Mansur Muhammad, Afeez Aruna, Maryrose Osazuwa, Ayodeji Yusuf, Isiaka Lawal, Bitrus Fidelis, Rephath Pius, Cyril Jomosu, Adebayo Adedayo, Abubakar Aliyu, Adaora Agholor, Abdullateef Abdulazeez, Chabiya Bala, Eziamaka Eze, Elizabeth Ani, Uchenna Okeke, Dominica Adebayo, Okechukwu Ekwunife, Victor Modekwe, Chuka Ugwunne, Chukwuemeka Okoro, Chisom Uche, Simeon Olateju, Fred Ige-Orhionkpaibima, Adedapo Adetoye, Olurotimi Aaron, Jeremiah Abimbola, Folayemi Faponle, Olumuyiwa Ajayeoba, Olusoji Jagun, Oluwabunmi Fatungase, Adeniyi Akiseku, Chigbundu Nwokoro, Ramotalai Shoyemi, Ibukunolu Ogundele, Nankat Joseph, Salihu Bura, Chukwuka Nwezoku, Manu Bwala, Meshach Philips, Abubakar Usman, Emmanuel Filibus, Zara Umate, Nwabuoke Chukwuka, Ahmed Nuhu, Watakiri Ibrahim, James Nggada, Ali Izge, Musa Ismail, Olayinka Eyelade, Tinuola Adigun, Babatunde Osinaike, Olayinka Ogunbode, Olusola Idowu, Taiwo Lawal, Temidayo Ogundiran, Olayiwola Shittu, Omobolaji Ayandipo, Stephen Edino, Zumnan Songden, Olumide Akitoye, Bissallah Ekele, Godwin Akaba, Terkaa Atim, Akitoye Adeleke, Owoicho Okochi, Sunday Akeju, Ernest Ukpoju, Osayomwanbo Osaheni, Ifunanya Obaseki, Lateef Kehinde, Osawemwenze Monday, Stanley Nte, Adesuwa Agboifo, Omajuwa Dawodu, Precious Orhiere, David Atiti, Queeneth Kalu, Felix Effiom, Israel Kolawole, Olawale Ojo, Afusat Olabinjo, Olufemi Ige, Beatrice Ogunyemi, Olusola Oladosu, Kikelomo Adesina, Sulaiman Agodirin, Asimiyu Shittu, Audu Idrisa, Sadiq Adamu, Nuhu Ali, Olayinka Adewunmi, Stephen Nwankwor, Akinwumi Olakanmi, Oluseye Ajayi, Ayotolu Ajayi, Victor Ogunmola, Oluwafunke Olakanmi, Adam Kuranga, Enoch Uche, Chukwuemeka Osuagwu, Chukwudi Ilo, Mesi Matthew, Uko Uko, Ngozi Mba, Olubusola Alagbe-Briggs, Amabra Dodiyi-Manuel, Bisola Onajin-Obembe, Bright Obasuyi, Richard Echem, Ihuoma Mike-Elechi, Job Otokwala, Mark Edubio, Catherine Eyo, Isaac Udo, Aliyu Abdulrahman, A.A. Abdullahi, Ibrahim Galadima Bello, Usman Adinoyin Mohammed, Abidemi Oyaromade, Mohammed Bello, Usman Muhammad, Emeri Mbah, Hyacinth Okereke, Almustapha Aminu, Anthony Ahmadu, Abu Rogers, Peter Samai, Sao Amara, Margaret Yankuba, Mary Josayah, Jayah Swarray Jnr, Alusine Dawo, Peter George, Mustapha Kabba, Mohamed Bah, Charles Mondeh, Ibrahim Kapuwa, Mohamed Sheku, Philip Mattia, Brima Sesay, Jones O.A. Omoshoro-Jones, Motselisi Mbeki, Estie Cloete, Philip Anderson, Busi Mrara, Annemarie Steyn, Tsakani Mhlari, Nic Proctor, Caroline Robertson, Gillian Lamacroft, Usha Singh, Sebenzile Sikhakhane, Kelly Gate, Shepherd Nzenza, John Tshimbalanga Kasonga, Sibongile Ndebele, Patrick Lufuta Kande, Jody Davids, Tino-vito Orlandi, Marischka de Jong, Hugo Stark, Francois Roodt, Jonathan Hall, Ian Nortje, Akanimo Akpakan, Vishendran Govindasamy, Ronisha Sathiram, Mohammad Kathrada, Zane Farina, Lucio Frittella, Charles Kohler, Sibuyiselwe Lubelwana, Sarwat Ikram-Hameed, Adriaan Smit, Muneerah Cassiem, Yvonne Freeman, Saaliha Goga, Larissa Cronje, Constantin Buzdugan, Subash Chirkut, Priyadeshni Singh, Sandhya Jithoo, Vivesh Rughubar, John Arnold, Rishan Bipath, Suman Mewa Kinoo, Ncumisa Khanyisa Msolo, Fleur Ackermans-Deijnen, Tshegofatso Mmasello Emma Boka, Martyn Biccard Greenwood, Shakthi Anand Jayrajh, Devarani Naidoo, Syndrini Reddy, Devandiran Harriraman Rungan, Kylene Subrayen, John Roos, Nina Tredoux, Pascal Plumacher, Anthony Reed, Harald Steinhaus, Mariesa Nock, Paul Ryan Herselman, Gareth Davies, Talitha Harvey, Franklin Muller, Willem Naude, Tania Pretorius, Johan Jochemus Swart, Merryn Walls, Prashant Gokal, Nicolette Rorke, Farzaana Dhoodhat, Precious Dzanibe, Mohammed Yusuf Hussain, Ashmita Junpath, Ameela Maharaj, Hylda Makanisi, Khalid Moosa, Ting Ting Wong, Sean Mould, Trisha Ramsamy, Roel Matos-Puig, Hayley Morgan, Nadeem Nabeebuccas, Ria Devi Naidoo, Viantha Pather, Vasheel Vasheel Bahadur, Renilda Pillay, Zahnne Fullerton, Nicole Bell, Bongisa Grey, Vincent Lorenzo Visentin, Hendrik Adriaan Van Zyl, Terri Anne Killingbeck, Emile Maneveldt, Gerhard Thiart, Magdelena May Venter, Oostewalt Swart, Mariette Grobelaar, Carel Cairns, David Bishop, Christien Steenkamp, Thandekile Khumalo, Noel Naidoo, Ross Murray, Martin Kopieniak, Melusi Sishange, Mxolisi Brian Ndimande, Megan Jaworska, Sarwat Ikram, Bence Rainier, Renier J. Liebenberg, Helena D. Zwiegers, Philip M. Nortje, Kamal Bhagwan, Margot Flint, Robert Dyer, Simone Adams, Yoshua Bwambale, Danny Ngomo, Patrice Kanku, Nivashen Pillay, Alexa de Castro, Atisha Maharaj, Janine Carim, Jenna Leigh Taylor, Karl M. Köhne, Leanne W. Drummond, Leanne Temlett, Lieze Geldenhuys, Yvonne Seilbea, Kathryn Naidoo, Nicola A. Kalafatis, Stefné Verwey, Thulile Biyase, Theroshnie Kisten, Belinda S. Kusel, Timothy Craig Hardcastle, Richard Magagula, Christian Kampik, Kuzolunga Xulu, Sivuyisiwe Solala, Mia Sayed, Basil Enicker, Anil Madaree, Innocent Mukama, Gladmore Madombwe, Nonhlanhla Zulu, Nompumelelo Gasa, Nokuzula Kanjana, Sebenzile Buthelezi, Thembelihle Buthelezi, Andries Brink, Francois Potgieter, Busisiwe Mrara, Zaynab Alexander, Charles Choto, Paula Ima, Zintle Gxagxisa, Baphethuxolo Ningiza, Gillian Lamacraft, Jerome Mogorosi, Nadia du Plessis, Leonie de Man, Suné Thompson, Gerrit van Heerden, Edwin W. Turton, Pieter M. van der Linde, Josephine K. Teme-Pitse, Reitumetse Tladi, Gillian D. Saffy, Ene-Mari Roscher, Kristel Fortune, George Barnard, Tiisetso Makhasane, Evan Bowen, Akangcha Pal, Rachel Moore, Maria Fourtounas, Mary Augusta Adam, Renessa Arumugan, Gabriella Hyman, Jaclyn Jonosky, Maninginingi Makondo, Heveshan Moodley, Phillip Munda, Mzwandile Nyalungu, Victor Olusola, Sohan Zane Pinto, Tristan Pillay, Lucinda Singh, Paul Mwindekuma Wondoh, John Devar, Boitumelo Baloyi-Mnisi, Zach Koto, Matlou Ernest Mabitsela, Sibongile Ruth Ndlovu, Branny Mthelebofu, Colin Beck, Matthew Dold, Alice Fan, Shannon MacQueen, Thembani Matabata, Catherine Mpehle, Charné Kulenkampf, Tsakani McCreath Mhlari, Simangele Cecilia Nyoka-Mokgalong, Felix Thumba Masinge, Randhir Ramnath Gunpath, Maropeng Petrus Pat Mothwa, Jo-Anne Asenath Mothwa, Danai Mhlanga, Jamie-Lyn Colly, Aunel Mallier Peter, Khalid Ben Hameda, Pulane Mokae, Stella Josephine Moumakoe, Kelechi Ekeh, Nezingu Lengo, Marnus Booyens, Inge Louise Seale, Pieter Daniel Theron, Nicolaas Abraham Schuman, Amber Carlyn Sonn, Jacobus Lukas Stander, Nadia Cloete, Marius Cloete, Catherine Ann Makepeace, Ronel van der Westhuizen, Leanne Robyn Messiahs, Amy Ruth Visagie, Fatima Vawda, Frans Christiaan Voster, Deepika Dhilraj, Oliver Smith, Stefan Bolon, Daniel Montwedi, Motsilisi Mbeki, Jayde Wyngaard, Mthunzi Ngcelwane, Thomas Kleyenstuber, Phyllis Phukubye, Liesel Schärf, Grace Laker, Elizabeth Semenya, Reinhard Dembskey, Thomas Tarlton, Tapiwa Jiri, Ngoie Hubert Mushid, Nhlanhla Samuel Ngwenya, Hazel Morongoa Mogodi, Carmen Sinevici, Anthony Osarogie Usenbo, Naledi Fodo, Anesu Chimini, Ntetelelo Sikobi, Sinovuyo Nokwange, Mluleki Noqhamza, Qumba Thembisa, Kajake Anantha Padmanabha Bhat, Rabin Mathew, Katrin Middleton, Abdus-sami Adewunmi, Craig Dickson, Humairah Bulbulia, Bianka Bester, Michelle de Klerk, Christia Benade, Francois Viljoen, Monique Fischer, Khalid Alfaki, Abdalmalik Awad, Abdelsalam Algray, Mohammed Elsiddig, Suha Mohamed, Salih Mahmoud, Muhammed Osman, Asia Elgailany, Mazin Suliman, Hanaa Mohammed, Lina Aljeally, Mohammed Dirar, Mohammed Osman, Mazin Mohamed, Mohamed Elhasan, Abrar Widatalla, Abubakr Abubakr, Eman Mohamed, Alshareef Nour, Ntonto Doris Gama, Dolorosa Khetsiwe Shabangu, Cynthia Iradikunda, Samuel Mkoko, Paul Kisanga, Emmanuel Lema, Benson Lyimo, Mohamed Binde, Alphonce Chandika, Salim Salim, Sylvia Jumbe, Abel Makubi, Vihar Kotecha, Felician Kachinde, Museleta Nyakiroto, Emmanuel Jitambi, Venant Geofrey, Johaphes Josiah, Phinius Makubi, Frank Manumbu, Suzan Mlingwa, Ernest Ibenzi, Peter Mbelle, Kato Peleus, Enid Chiwanga, Nillah Richard, Shoo Leonard, Paulo Sanka, Subira Mushi, Bashir Nyangasa, Mohamed Janabi, Naizihijwa Majani, Pedro Palangyo, Evarist Nyawawa, William Ramadhan, Faraj Lydenge, Gileard Gabriel Masenga, Sakina Rashid, Mubashir Jusabani, Ansbert Ndebea, Jenitha Cheru, Margaret Henjewele, Greyson Kilimanjaro, Sarah Sikimata, Deocles Donatus, Hazina Maduhu, Tumaini Mariro, Given Massasi, Moshi Moshi Shabani, Braison Cholela, Marco Mgeleka, Yohatinus Mbilinyi, Faraja Chiwanga, Bilton Exavery, Caspar Haule, Samson Ndile, Sirili Harya, Julieth Magandi, Deogratius Manyama, Redempta Matindi, Adam Moshi, Daudi Kitwana, Merida Makia, Philip Muhochi, Miriam Herman, Clauda Miombo, Furaha Kahindo, Langtone Kishebuka, Elijah Ussiri, Gloria Kinasa, Patrick Adel, Eric Malaba, Vensesla Sakwari, Sadot Lugereka, Mohamed Mungia, George Mocha, Herman Wella, Cecilia Protas, Patrick Karua, Ahmada Kashagama, Faraja Mwasambugu, Suzana Kajeri, Jacquiline Mchilla, Elibariki Lucumay, Robert Maise, Amon Marti, Beatrice Mahundi, Frederika Jager, Charles Majani, Ludovick Rukeha, Tareeq Mohamed, Nabila Fuad, Winifrida Halinga, Elias Chrisant, Gilbert Msoma, Titus Kihwili, Gadiel Temu, Naima Yusuf, Rashid Saleh, Rashid Inoja, Eva Shang'a, Stella Ibrahim, Hussein Msuma, Edwin Edward, Paul Kilamile, Stephen Mwakyolile, Talkana Adja, Edem Gueouguede, Hafoudhoi Oussene Seddoh, Saliou Adam, Pilakimwe Egbohou, Mawunyo Ahomagnon, Olivier Kadjossou, Abdul-Bassiti Boukari, Mary T. Nabukenya, Ruth Muhindo, Peter Waswa, Peter Kaahwa Agaba, Daphne Kabatoro, Joseph Kayongo, Margaret Naggujja, Nabasiige Rehema, Phiona Nansubuga, Daniel Kavuma, Aggrey Lubikire, Hope Bisilikirwa, Godfrey Ssebaggala, Emmanuel Muwema, Humble Joan Agaba, John Kiconco, Nicholas Wataaka, Bonet Chan, Mary Juliet Nampawu, Fred Bulamba, Emmanuel Bua, Christine Mugala, Caroline Nyakato, John Paul Ochieng, Linda Kyomuhendo Jovia, George Kateregga, Rachel Alum, Lazia Najjuma, Gorret Nampiina, Andrew Kintu, Joshua Sempiira, Luzige Simon, Peter Kayima, Jacob Eyul, Erick Odwar, Rita Nkwine, Christine Namata, Elizabeth Nabakka, Denis Kakaire, Velda Mushangwe-Mtisi, Erisha Munhamo, Celestino Dhege, Juliet Hungwa, Hemish Jasi, Crispin Ntoto, Derek Matsika, Brightson Mutseyekwa, Joseph Zimbovoora, Beaulah Gudyanga, Dennis Mazingi, Chenesa Mbanje, Busisiwe Mlambo, Michael Chiwanga, Harunavamwe N. Chifamba, Sarudzai Zhou, Esta Hove, Shamiso Dende, Beauty Manjengwa, Penias Kapisa, null Mashava, Caritas Chiura, Locadia Katsukunya, Godfrey Muguti, Doreen Mashava, Elton Ndhlovu, Zanele Mangwangwa, and Nombulelo Dube
Subjects: medicine.medical_specialty, Interprofessional Relations, media_common.quotation_subject, Psychological intervention, Fidelity, Postoperative Complications, Surveys and Questionnaires, Intervention (counseling), Humans, Medicine, Postoperative Period, Cooperative Behavior, Nursing management, media_common, Response rate (survey), business.industry, Standard of Care, Odds ratio, Hospitals, Confidence interval, Clinical trial, Anesthesiology and Pain Medicine, Population Surveillance, Africa, Physical therapy, business
Abstract: Background The African Surgical OutcomeS-2 (ASOS-2) trial tested an enhanced postoperative surveillance intervention to reduce postoperative mortality in Africa. We undertook a concurrent evaluation to understand the process of intervention delivery. Methods Mixed-methods process evaluation, including field notes, interviews, and post-trial questionnaire responses. Qualitative analysis used the framework method with subsequent creation of comparative case studies, grouping hospitals by intervention fidelity. A post-trial questionnaire was developed using initial qualitative analyses. Categorical variables were summarised as count (%) and continuous variables as median (inter-quartile range [IQR]). Odds ratios (OR) were used to rank influences by impact on fidelity. Results The dataset included eight in-depth case studies, and 96 questionnaire responses (response rate 67%) plus intervention fidelity data for each trial site. Overall, 57% (n=55/96) of hospitals achieved intervention delivery using an inclusive definition of fidelity. Delivery of the ASOS-2 interventions and data collection presented a significant burden to the investigators, outstripping limited resources. The influences most associated with fidelity were: surgical staff enthusiasm for the trial (OR=3.0; 95% confidence interval [CI], 1.3–7.0); nursing management support of the trial (OR=2.6; 95% CI, 1.1–6.5); performance of a dummy run (OR=2.6; 95% CI, 1.1–6.1); nursing colleagues seeing the value of the intervention(s) (OR=2.1; 95% CI, 0.9–5.7); and site investigators' belief in the effectiveness of the intervention (OR=3.2; 95% CI, 1.2–9.4). Conclusions ASOS-2 has proved that coordinated interventional research across Africa is possible, but delivering the ASOS-2 interventions was a major challenge for many investigators. Future improvement science efforts must include better planning for intervention delivery, additional support to investigators, and promotion of strong inter-professional teamwork. Clinical trial registration ClinicalTrials gov NCT03853824.
Published: 2021
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11. Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

Author: Akowuah, Enoch, Benson, Ruth A., Caruana, Edward J., Chetty, Govind, Edwards, John, Forlani, Stefano, Gradinariu, George, Murphy, Gavin J., Oo, Aung Ye, Patel, Akshay J., Ridley, Brenda, Rogers, Luke J., Sanders, Julie, Tyson, Nathan, Vaja, Ricky, Siaw-Acheampong, Kwabena, Argus, Leah, Chaudhry, Daoud, Dawson, Brett E., Glasbey, James C., Gujjuri, Rohan R., Jones, Conor S., Kamarajah, Sivesh K., Khatri, Chetan, Keatley, James M., Lawday, Samuel, Li, Elizabeth, Mann, Harvinder, Marson, Ella J., Mclean, Kenneth A., Picciochi, Maria, Taylor, Elliott H., Tiwari, Abhinav, Simoes, Joana FF., Trout, Isobel M., Venn, Mary L., Wilkin, Richard JW., Bhangu, Aneel, Nepogodiev, Dmitri, Dajti, Irida, Gjata, Arben, Boccalatte, Luis, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Townend, Philip, Aigner, Felix, Kronberger, Irmgard, Hossain, Kamral, VanRamshorst, Gabrielle, Lawani, Ismail, Ataide, Gustavo, Baiocchi, Glauco, Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Olivos, Maricarmen, Calvache, Jose, Perez Rivera, Carlos Jose, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Klat, Jaroslav, Novysedlak, René, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango, Eddy, Emile, Sameh H., Mengesha, Mengistu Gebreyohanes, Hailu, Dr. Samuel, Tamiru, Hailu, Kauppila, Joonas, Laukkarinen, Johanna, Arnaud, Alexis, Albertsmeiers, Markus, Lederhuber, Hans, Loffler, Markus, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Lorena, Maria Aguilera, Grecinos, Gustavo, Mersich, Tamas, Wettstein, Daniel, Ghosh, Dhruv, Kembuan, Gabriele, Brouk, Peiman, Khosravi, Mohammad, Mozafari, Masoud, Adil, Ahmed, Mohan, Helen M., Zmora, Oded, Fiore, Marco, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Satoi, Sohei, Ayasra, Faris, Chaar, Mohammad, Fakhradiyev, Ildar R., Jamal, Mohammad, Elhadi, Muhammed, Gulla, Aiste, Roslani, April, Martinez, Laura, Ramos De La Medina, Antonio, Outani, Oumaima, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, van der Plas, Willemijn, Ademuyiwa, Adesoji, Osinaike, Babatunde, Seyi-olajide, Justina, Williams, Emmanuel, Pejkova, Sofija, Augestad, Knut Magne, Soreide, Kjetil, Al Balushi, Zainab, Qureshi, Ahmad, Sayyed, Raza, Mohsen Daraghmeh, Mustafa Abu, Abukhalaf, Sadi, Cukier, Moises, Gomez, Hugo, Shu, Sebastian, Vasquez, Ximena, Parreno-Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel, Santos, Irene, Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Litvin, Andrey, Ntirenganya, Faustin, AlAmeer, Ehab, Radenkovic, Dejan, Hong Xiang, Frederick Koh, Hoe, Chew Min, Chi Yong, James Ngu, Moore, Rachel, Nhlabathi, Ncamsile, Colino, Ruth Blanco, Bravo, Ana Minaya, Minaya-Bravo, Ana, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Elmujtaba, Mohammed, Jebril, William, Rutegård, Martin, Sund, Malin, Isik, Arda, Leventoğlu, Sezai, Abbott, Tom EF., Benson, Ruth, Caruna, Ed, Chakrabortee, Sohini, Demetriades, Andreas, Desai, Anant, Drake, Thomas D., Edwards, John G., Evans, Jonathan P., Ford, Samuel, Fotopoulou, Christina, Griffiths, Ewen, Hutchinson, Peter, Jenkinson, Michael D., Khan, Tabassum, Knight, Stephen, Kolias, Angelos, Leung, Elaine, McKay, Siobhan, Norman, Lisa, Ots, Riinu, Raghavan, Vidya, Roberts, Keith, Schache, Andrew, Shaw, Richard, Shaw, Katie, Smart, Neil, Stewart, Grant, Sundar, Sudha, Vimalchandran, Dale, Wright, Naomi, Alshryda, Sattar, Alser, Osaid, Breen, Kerry, Ganly, Ian, Kaafarani, Haytham, Kendall, Brittany, Mashbari, Hassan, Al Naggar, Hamza, Mazingi, Dennis, Simoes, Joana F. 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D., Kahn, A., Gueutier, A., Bigot, P., Borraccino, B., Lakkis, Z., Doussot, A., Heyd, B., Manfredelli, S., Mathieu, P., Paquette, B., Turco, C., Barrabe, A., Louvrier, A., Moszkowicz, D., Giovinazzo, D., Bretagnol, F., Police, A., Charre, L., Volpin, E., Braham, H., El Arbi, N., Villefranque, V., Bendjemar, L., Girard, E., Abba, J., Trilling, B., Chebaro, A., Lecolle, K., Truant, S., El Amrani, M., Zerbib, P., Pruvot, F. R., Mathieu, D., Surmei, E., Mattei, L., Marin, H., Christou, N., Ballouhey, Q., Ferrero, P., Coste Mazeau, P., Tricard, J., Barrat, B., Taibi, A., Usseglio, J., Laloze, J., Salle, H., Fourcade, L., Duchalais, E., Regenet, N., Rigaud, J., Waast, D., Denis, W., Malard, O., Buffenoir, K., Espitalier, F., Ferron, C., Varenne, Y., Crenn, V., De Vergie, S., Cristini, J., Samarut, E., Tzedakis, S., Bouche, P. 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C., Schineis, C., Loch, F. N., Beyer, K., Nasser, S., Sehouli, J., Höhn, P., Braumann, C., Reinkemeier, F., Uhl, W., Weitz, J., Bork, U., Welsch, T., Praetorius, C., Korn, S., Distler, M., Fluegen, G., Knoefel, W. T., Vay, C., Golcher, H., Grützmann, R., Binder, J., Meister, P., Gallinat, A., Paul, A., Schnitzbauer, A. A., Thoenissen, P., El Youzouri, H., Schreckenbach, T., Nguyen, T. A., Eberbach, H., Bayer, J., Erdle, B., Sandkamp, R., Nitschke, C., Izbicki, J., Uzunoglu, F. G., Koenig, D., Gosau, M., Böttcher, A., Heuer, A., Klatte, T. O., Priemel, M., Betz, C. S., Burg, S., Möckelmann, N., Busch, C. J., Bewarder, J., Zeller, N., Smeets, R., Thole, S., Vollkommer, T., Speth, U., Stangenberg, M., Hakami, I., Boeker, C., Mall, J., Schardey, H. M., von Ahnen, T., von Ahnen, M., Brunner, U., Tapking, C., Kneser, U., Hirche, C., Jung, M., Kowalewski, K. F., Kienle, P., Reissfelder, C., Seyfried, S., Herrle, F., Hardt, J., Galata, C., Birgin, E., Rahbari, N., Vassos, N., Stoleriu, M. G., Hatz, R., Albertsmeier, M., Börner, N., Lampert, C., Werner, J., Kuehlmann, B., Prantl, L., Brunner, S. M., Schlitt, H. J., Brennfleck, F., Pfister, K., Oikonomou, K., Reinhard, T., Nowak, K., Ronellenfitsch, U., Kleeff, J., Delank, K. S., Michalski, C. W., Szabo, G., Widyaningsih, R., Stavrou, G. A., Bschorer, R., Mielke, J., Peschel, T., Königsrainer, A., Quante, M., Löffler, M. W., Yurttas, C., Doerner, J., Seiberth, R., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Syllaios, A., Baili, E., Schizas, D., Liakakos, T., Charalabopoulos, A., Zografos, C., Spartalis, E., Manatakis, D. K., Tasis, N., Antonopoulou, M. I., Xenaki, S., Xynos, E., Chrysos, E., Athanasakis, E., Tsiaousis, J., Lostoridis, E., Tourountzi, P., Tzovaras, G., Tepetes, K., Zacharoulis, D., Baloyiannis, I., Perivoliotis, K., Hajiioannou, J., Korais, C., Gkrinia, E., Skoulakis, C. E., Saratziotis, A., Koukoura, O., Symeonidis, D., Diamantis, A., Tsoulfas, G., Christou, C. D., Tooulias, A., Papadopoulos, V., Anthoulakis, C., Grimbizis, G., Zouzoulas, D., Tsolakidis, D., Tatsis, D., Christidis, P., Loutzidou, L., Ioannidis, O., Astreidis, I., Antoniou, A., Antoniadis, K., Vachtsevanos, K., Paraskevopoulos, K., Kalaitsidou, I., Alexoudi, V., Stavroglou, A., Mantevas, A., Michailidou, D., Grivas, T., Deligiannidis, D., Politis, S., Barrios Duarte, A., Portilla, A. L., Lowey, M. J., Recinos, G., Lopez Muralles, I., Siguantay, M. A., Estrada, E. E., Aguilera-Arévalo, M. L., Cojulun, J. M., Echeverría-Dávila, G., Marín, C., Icaza de Marín, G. C., Kok, S. Y., Joeng, H. K. M., Chan, L. L., Lim, D., Novak, Z., Echim, T., Suszták, N., Banky, B., Kembuan, G., Pajan, H., Islam, A. A., Rahim, F., Safari, H., Mozafari, M., Brouki Milan, P., Tizmaghz, A., Rezaei Tavirani, M., Ahmed, A., Hussein, R., Fleming, C., O'Brien, S., Kayyal, M. Y., Daly, A., Killeen, S., Corrigan, M., De Marchi, J., Hill, A., Farrell, T., Davis, N. F., Kearney, D., Nelson, T., Maguire, P. J., Barry, C., Farrell, R., Smith, L. A., Mohan, H. M., Mehigan, B. J., Mccormick, P., Larkin, J. O., Fahey, B. A., Rogers, A., Donlon, N., O'Sullivan, H., Nugent, T., Reynolds, J. V., Donohue, C., Shokuhi, P., Ravi, N., Fitzgerald, C., Lennon, P., Timon, C., Kinsella, J., Smith, J., Boyle, T., Alazawi, D., Connolly, E., Butt, W., Croghan, S. M., Manecksha, R. P., Fearon, N., Winter, D., Heneghan, H., Maguire, D., Gallagher, T., Conlon, K., Kennedy, N., Martin, S., Kennelly, R., Hanly, A., Ng, K. C., Fagan, J., Geary, E., Cullinane, C., Carrington, E., Geraghty, J., McDermott, E., Pritchard, R., McPartland, D., Boland, M., Stafford, A., Geoghegan, J., Elliott, J. A., Ridgway, P. F., Gillis, A. E., Bass, G. A., Neary, P. C., O'Riordan, J. M., Kavanagh, D. O., Reynolds, I. S., K, Conlon, Joyce, D. P., Boyle, E., Egan, B., Whelan, M., Elkady, R., Tierney, S., Connelly, T. M., Earley, H., Umair, M., O'Connell, C., Thomas, A. Z., Rice, D., Madden, A., Bashir, Y., Creavin, B., Cullivan, O., Owens, P., Canas-Martinez, A., Murphy, C., Pickett, L., Murphy, B., Mastrosimone, A., Beddy, D., Arumugasamy, M., Allen, M., Aremu, M., McCarthy, C., O’Connor, C., O'Connor, D. B., Kent, E., Malone, F., Geary, M., McKevitt, K. L., Lowery, A. J., Ryan, É. J., Aherne, T. M., Fowler, A., Hassanin, A., Hogan, A. M., Collins, C. G., Finnegan, L., Carroll, P. A., Kerin, M. J., Walsh, S. R., Nally, D., Peirce, C., Coffey, J. C., Cunningham, R. M., Tormey, S., Hardy, N. P., Neary, P. M., Muallem-Kalmovich, L., Kugler, N., Lavy, R., Zmora, O., Horesh, N., Vergari, R., Mochet, S., Barmasse, R., Usai, A., Morelli, L., Picciariello, A., Papagni, V., Altomare, D. F., Colledan, M., Zambelli, M. F., Tornese, S., Camillo, A., Rausa, E., Bianco, F., Lucianetti, A., Prucher, G. M., Baietti, A. M., Ruggiero, F., Maremonti, P., Neri, F., Ricci, S., Biasini, M., Zarabini, A. G., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Della Gatta, A. N., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pilu, G., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Tonini, V., Sartarelli, L., Cervellera, M., Gori, A., Armatura, G., Scotton, G., Patauner, S., Frena, A., Podda, M., Pisanu, A., Esposito, G., Frongia, F., Abate, E., Laface, L., Casati, M., Schiavo, M., Casiraghi, T., Sammarco, G., Gallo, G., Vescio, G., Fulginiti, S., Scorcia, V., Giannaccare, G., Carnevali, A., Giuffrida, M. C., Marano, A., Palagi, S., Di Maria Grimaldi, S., Testa, V., Peluso, C., Borghi, F., Simonato, A., Puppo, A., D'Agruma, M., Chiarpenello, R., Pellegrino, L., Maione, F., Cianflocca, D., Pruiti Ciarello, V., Giraudo, G., Gelarda, E., Dalmasso, E., Abrate, A., Daniele, A., Ciriello, V., Rosato, F., Garnero, A., Leotta, L., Giacometti, M., Zonta, S., Lomiento, D., Taglietti, L., Dester, S., Compagnoni, B., Viotti, F., Cazzaniga, R., Del Giudice, R., Mazzotti, F., Pasini, F., Ugolini, G., Fabbri, N., Feo, C. V., Righini, E., Gennari, S., Chiozza, M., Anania, G., Urbani, A., Koleva Radica, M., Carcoforo, P., Portinari, M., Sibilla, M., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M. N., Risaliti, M., Sorbi, F., Taddei, A., Lizzi, V., Vovola, F., Arminio, A., Cotoia, A., Sarni, A. L., Familiari, P., D'Andrea, G., Picotti, V., Bàmbina, F., Fontana, T., Barra, F., Ferrero, S., Gustavino, C., Kratochwila, C., Ferraiolo, A., Costantini, S., Batistotti, P., Aprile, A., Almondo, C., Ball, L., Robba, C., Scabini, S., Pertile, D., Massobrio, A., Soriero, D., D'Ugo, S., Depalma, N., Spampinato, M. G., Lippa, L., Gambacciani, C., Santonocito, O. S., Aquila, F., Pieri, F., Ballabio, M., Bisagni, P., Longhi, M., Armao, T., Madonini, M., Gagliano, A., Pizzini, P., Costanzi, A., Confalonieri, M., Monteleone, M., Colletti, G., Frattaruolo, C., Mari, G., Spinelli, A., Mercante, G., Spriano, G., Gaino, F., Ferreli, F., De Virgilio, A., Rossi, V., Carvello, M. M., Di Candido, F., Kurihara, H., Marrano, E., Torzilli, G., Castoro, C., Carrano, F. M., Martinelli, F., Macchi, A., Fiore, M., Pasquali, S., Cioffi, S. P. B., Baia, M., Abatini, C., Sarre, C., Mosca, A., Biasoni, D., Gronchi, A., Citterio, D., Mazzaferro, V., Cadenelli, P., Gennaro, M., Capizzi, V., Guaglio, M., Sorrentino, L., Bogani, G., Sarpietro, G., Giannini, L., Comini, L. V., Rolli, L., Folli, S., Raspagliesi, F., Piazza, C., Cosimelli, M., Salvioni, R., Antonelli, B., Baldari, L., Boni, L., Cassinotti, E., Pignataro, L., Rossi, G., Torretta, S., Beltramini, G. A., Gianni', A., Tagliabue, M., De Berardinis, R., Pietrobon, G., Chu, F., Cenciarelli, S., Adamoli, L., Ansarin, M., Fumagalli Romario, U., Mastrilli, F., Mariani, N. M., Nicastro, V., Cellerino, P., Colombo, F., Frontali, A., Bondurri, A., Guerci, C., Maffioli, A., Ferrario, L., Candiani, M., Bonavina, G., Ottolina, J., Valsecchi, L., Mortini, P., Gagliardi, F., Piloni, M., Medone, M., Negri, G., Bandiera, A., De Nardi, P., Sileri, P., Carlucci, M., Pelaggi, D., Rosati, R., Vignali, A., Parise, P., Elmore, U., Tamini, N., Nespoli, L. C., Rennis, M., Pitoni, L., Chiappetta, M. F., Vico, E., Fruscio, R., Grassi, T., Sasia, D., Migliore, M., Gattolin, A., Rimonda, R., Travaglio, E., Olearo, E., Tufo, A., Marra, E., Maida, P., Marte, G., Tammaro, P., Incollingo, P., Izzo, F., Belli, A., Patrone, R., Albino, V., Leongito, M., Granata, V., Piccirillo, M., Palaia, R., Francone, E., Gentilli, S., Nikaj, H., Fiorini, A., Norcini, C., Chessa, A., Marino, M. V., Mirabella, A., Vaccarella, G., Musini, L., Ampollini, L., Bergonzani, M., Varazzani, A., Bellanti, L., Domenichini, M., Cabrini, E., Fornasari, A., Freyrie, A., Dejana, D. O., D'Angelo, G., Bertoli, G., Di Lella, F., Bocchialini, G., Falcioni, M., Lanfranco, D., Poli, T., Giuffrida, M., Annicchiarico, A., Perrone, G., Catena, F., Raffaele, A., De Manzoni Garberini, A., Baldini, E., Conti, L., Ribolla, M., Capelli, P., Isolani, S. M., Maniscalco, P., Cauteruccio, M., Ciatti, C., Puma Pagliarello, C., Gattoni, S., Galleano, R., Malerba, M., Ciciliot, M., Farnesi, F., Calabrò, M., Pipitone Federico, N. S., Lunghi, E. G., Muratore, A., Di Franco, G., Palmeri, M., Tartaglia, D., Coccolini, F., Chiarugi, M., Simoncini, T., Gadducci, A., Caretto, M., Giannini, A., Perutelli, A., Domenici, L., Garibaldi, S., Capanna, R., Andreani, L., Furbetta, N., Guadagni, S., Bianchini, M., Gianardi, D., Pinotti, E., Montuori, M., Carissimi, F., Baronio, G., Zizzo, M., Castro Ruiz, C., Annessi, V., Montella, M. T., Falco, G., Mele, S., Ferrari, G., Mastrofilippo, V., Mandato, V. D., Aguzzoli, L., Corbellini, C., Baldi, C., Sampietro, G. M., Palini, G. M., Zanini, N., Garulli, G., Barone, R., Murgese, A., Mungo, S., Grasso, M., Marafante, C., Birolo, S. L., Moggia, E., Caccetta, M., Masciandaro, A., Deirino, A., Garino, M., Perinotti, R., Maiello, F., Gordini, L., Lombardi, C. P., Marzi, F., Marra, A. A., Ratto, C., Di Muro, M., Litta, F., De Simone, V., Cozza, V., Rosa, F., Agnes, A., Parello, A., Alfieri, S., Sganga, G., Lapolla, P., Mingoli, A., De Toma, G., Fiori, E., La Torre, F., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G. B., Cicerchia, P. M., Bruzzaniti, P., Santoro, A., Frati, A., Marruzzo, G., Ribuffo, D., Sagnotta, A., Marino Cosentino, L., Mancini, S., Lisi, G., Spoletini, D., Bellato, V., Campanelli, M., Sica, G., Siragusa, L., Bonavina, L., Asti, E., Bernardi, D., Lovece, A., Perra, T., Porcu, A., Fancellu, A., Feo, C. F., Scanu, A. M., Tuminello, F., Franceschi, A., Langone, A., Fleres, F., Spolini, A., Bordoni, P., Franzini, M., Clarizia, G., Grechi, A., Longhini, A., Guaitoli, E., Manca, G., Grossi, U., Novello, S., Zanus, G., Romano, M., Rossi, S., Ferrara, F., La Torre, M., Pirozzolo, G., Recordare, A., Paiella, S., Turri, G., Rattizzato, S., Campagnaro, T., Guglielmi, A., Pedrazzani, C., Ruzzenente, A., Poletto, E., Conci, S., Casetti, L., Fontana, M., Salvia, R., Malleo, G., Esposito, A., Landoni, L., De Pastena, M., Bassi, C., Tuveri, M., Nobile, S., Marchegiani, G., Bortolasi, L., Sambugaro, E., Malavolta, M., Moretto, G., Impellizzeri, H., Inama, M., Barugola, G., Ascari, F., Ruffo, G., Granieri, S., Cotsoglou, C., Berselli, M., Desio, M., Marchionini, V., Cocozza, E., Di Saverio, S., Ietto, G., Iovino, D., Carcano, G., Ayasra, F., Qasem, A., Ayasra, Y., Al-Masri, M., Abou Chaar, M. K., Al-Najjar, H., Ghandour, K., Alawneh, F., Abdel Jalil, R., Abdel Al, S., Elayyan, M., Ghanem, R., Lataifeh, I., Alsaraireh, O., Abu Za’nouneh, F. J., Fahmawee, T., Ibrahim, A., Obeidat, K., Lee, K. J., Shin, S. J., Chung, H., Albader, I., Alabbad, J., Albader, M. A. S., Bouhuwaish, A., Taher, A. S., Omar, M. S. M., Abdulwahed, E., Biala, M., Morgom, M., Elhadi, A., Alarabi, A., Msherghi, A., Elhajdawe, F., Alsoufi, A., Salamah, A., Salama, H., Bulugma, M., Almabrouk, H., Venskutonis, D., Dainius, E., Kubiliute, E., Bradulskis, S., Parseliunas, A., Kutkevicius, J., Subocius, A., Cheong, Y. J., Masood, M. S., Ngo, C. W., Saravanan, R., Abdul Maei, N., Hayati, F., Amin Sahid, N., Yanowsky Reyes, G., Orozco Perez, J., Damian, R., Santana Ortiz, R., Colunga Tinajero, C. A., Cordera, F., Gómez-Pedraza, A., Maffuz-Aziz, A., Posada, J. A., De la Rosa Abaroa, M. A., Alvarez, M. R., Arrangoiz, R., Hernández, R., Bozada Gutierrez, K., Trejo-Avila, M., Valenzuela-Salazar, C., Herrera-Esquivel, J., Moreno-Portillo, M., Pinto-Angulo, V. M., Sosa-Duran, E. E., Ziad-Aboharp, H., Jimenez Villanueva, X., Soulé Martínez, C. E., Lupián-Angulo, A. I., Martínez Zarate J, Jacobo, Reyes Rodriguez, E., Montalvo Dominguez, G., Becerra García, F. C., Melchor-Ruan, J., Vilar-Compte, D., Romero-Bañuelos, E., Herrera-Gomez, A., Meneses-Garcia, A., Isla-Ortiz, D., Salcedo-Hernández, R. A., Hernández-Nava, J. M., Morales-Castelan, J. E., Posadas-Trujillo, O. E., Buerba, G. A., Alfaro-Goldaracena, A., Pena Gomez-Portugal, E., Lopez-Pena, G., Hinojosa, C. A., Mercado, M. A., Ramos-De la Medina, A., Martinez, L., Duran, I., Gonzalez, D. S., Martinez, M. J., Nayen Sainz de la Fuente, A., Miguelena, L., Hernández Miguelena, L., Louraoui, S. M., El Azhari, A., Rghioui, M., Khya, E., Ghannam, A., Souadka, A., El Ahmadi, B., Belkhadir, Z. H., Majbar, M. A., Benkabbou, A., Mohsine, R., Oudrhiri, M. Y., Bechri, H., Arkha, Y., El Ouahabi, A., Frima, H., Bachiri, S., Groen, L. C., Verhagen, T., ter Brugge, F. M., Scheijmans, J. C. G., Boermeester, M. A., Hompes, R., Meima-van Praag, E. M., Sharabiany, S., Borgstein, A. B. J., Gisbertz, S. S., van Berge Henegouwen, M. I., Gans, S., Van Duijvendijk, P., Herklots, T., De Hoop, T., De Graaff, M. R., Sloothaak, D., Bolster-van Eenennaam, M., Baaij, J., Klinkenbijl, J. H. G., Van Eekeren, R., Spillenaar Bilgen, E. J., Van der Burg, S. W., Harlaar, N. J., Jonker, F. H. W., Vermaas, M., Voigt, K. R., Nellensteijn, D., Bensi, E. A. B., Posma-Bouman, L., Van Sambeek, M., Holscher, M., Van den den Broek, W. T., HKruijff, S., De Vries, J. P. P. M., Steinkamp, P. J., Jonker, P. K. C., Van der Plas, W. Y., Bierman, W., Janssen, Y., Franken, J., Oosterling, S., Boerma, E. G., Schweitzer, D., Keulen, M. H. F., Ketting, S., Wegdam, J. A., Vries Reilingh, T. S., de Schipper, Teeuwen, P. H. E., Hendriks, E. R., Van Geloven, A. A. W., Emous, M., Poelstra, R., Teunissen, M., Gerritsen, S. L., Boerma, D., De Reuver, P. R., Thunnissen, F., Vermeulen, B. A. M., Groen, A., Van Ginhoven, T. M., Viëtor, C. L., van der Oest, M. J. W., Vriens, P. W. H. E., Houwen, T., Heisterkamp, J., van Petersen, A. S., van der Meij, W., Stevens, C. T., Pronk, A., Bakker, W. J., Richir, M. C., Vriens, M. R., Filipe, M. D., Uittenbogaart, M., Leclercq, W. K. G., Sijmons, J. M. L., Vancoillie, P. J., Konsten, J., Van Heinsbergen, M., Dekker, N. A. M., den Boer, F. C., Akinmade, A., Adeyeye, A., Enoch, E., Fayose, S., Okunlola, A. I., Adeniyi, A. A., Adeyemo, O. T., Adebara, I. O., Bakare, A., Babalola, O. F., Abiyere, O. H., Banjo, O. O., Olori, S., Akaba, O. G., Agida, E. T., Abdullahi, I. H., Egbuchulem, I. K., Olulana, D., Lawal, T. A., Ogundoyin, O., Oyelakin, O. A., Nwaorgu, O. G., Sule, S. O., Makwe, C. C., Afolabi, B. B., Seyi-Olajide, J. O., Ademuyiwa, A. O., Bode, C. 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A., Cárdenas Ruiz de Castilla, D., Mansilla Doria, P., Li Valencia, M. R., Salazar, A., Sarmiento, A., Díaz, C., Morales, E., Ore, E., Zegarra, H., Siccha, J., Guardia, M., Sandoval, M., Mendiola, G. C., Mimbela, M., Diaz-Ruiz, R., Zeta, L. A., Cordova-Calle, E., Nuñez, H. M., Ortiz-Argomedo, M. R., Caballero-Alvarado, J., Salazar-Tantaleán, A., Espinoza-Llerena, R., Aliaga-Ramos, M., Asodisen, O., Jabagat, E., Tedoy, C. M., Ramos, R. A., Lopez, M. P. J., Violago, K. L. E., Aram, R., Carlos Santos, P., Filarca, R. F., Carlos, A., Santos, P., Filarca, R. L., Domingo, E. J., Khu, K. J. O., Lapitan, M. C., Sacdalan, M. D. P., Kho, M. J. N., Baticulon, R. E., Bravo, S. L. R., Cueto, M. A. C., Ramos, C. L., Fuentes, J. R., Sadian, H., Gumarao, A., Barraquio, A., Cruz, E. M., Gonzales, A. D., Reyes, J. A. S., Salud, J. A., Tancinco, E. G., Rivera, R. D., Lim, J. A., Barcelon, J. C., Chiu, J. A., Carballo, M. 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W., Gudal, A., Alasmari, A., Alqahtani, S., Majrashi, S., Mashat, A., Al Raddadi, R., Alharbi, A., Nasser, Y., Hamayel, H., Alhojaili, A., Aljohani, R., Sogair, O., Alfarhan, O., Alzahrani, A., Alzomaili, B., A Azab, M., Alotaibi, M., Maashi, A., Zowgar, A., Alsakkaf, M., Alnemary, M., Khayat, S., Felmban, S., Almhmadi, A., Alqannas, M., Cortés Guiral, D., Alyami, M., Elawad, A., Alhefdhi, A., Alresaini, F., Kurdi, W., Tulbah, M., Aldakheel, M., Alsahan, N., Koussayer, S., Elsheikh, H., Al-qattan, M., Alshanafey, S., Rafique, A., Mahabbat, N., Saeed, B., Al-Kharashi, E., Alsowaina, K., Arab, N., Aljaber, F., Al Hasan, I., Alghamdi, A., Badahdah, F., Alghuliga, A., Abdulfattah, F., Alanazi, F., Albaqami, F., Alsuhaibani, A., AlFakhri, A., Alqasem, S., Alajaji, N., Nouh, T., Bin Nasser, A., Alowais, J., Alburakan, A., Alamri, O., Albdah, A., Alawi, K., Alshalhoub, M., ElSanhoury, K., Almofarreh, A., Ibrahim, S., Elshafie, H., Osman, I., Guzman, T., Mutair, H., Siddiqui, A., Chowdhury, S., Alghamdi, R., Almutrafi, S., Alfaifi, J., D'Souza, J., Alshitwi, A., Alkreedees, N., Alramadhan, M., Alshehri, M., Alobaysi, S., Alshahrani, A., Alshehri, A., Alrashed, M., Altahan, T., Alsabahi, T., Alhossaini, R., Sbaih, M., Alalawi, Y., Alnwijy, K., Al Ayed, A., Ghedan, S., Alharthi, R., Awad, S., I Sharara, M., Abdelrhman, S., Althobaiti, W., Srbinovic, L., Perovic, M., Mikovic, Z., Nikolic, B., Vasiljevic, M., Pazin, V., Mandic Markovic, V., Dimitrijevic, D., Zecevic, N., Gregoric, P., Micic, D., Loncar, Z., Doklestic, K., Ivancevic, N., Djukic, V., Stojakov, D., Ilic, R., Savic, P., Pijanovic, N., Milanovic, M., Radosavljevic, M., Dejanovic, T., Kostic, M., Paskas, J., Bojic, S., Stevanovic, P., Djuric, M., Kadija, M., Tulic, G., Glisovic Jovanovic, I., Lieske, B., Kayombo, E., Kruger, I., De Kock, M., Malan, A., Ferreira, C., Du Preez, H., Mulder, W., Noel, C., Le Grange, S., Lusawana, O., Kies, C., Steyn, E., Janson, J., Buitendag, J. 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B., Morales, X., Carreras-Castañer, A., Torner, P., Jornet-Gibert, M., Balaguer-Castro, M., Renau-Cerrillo, M., Camacho-Carrasco, P., Vives-Barquiel, M., Campuzano-Bitterling, B., Gracia, I., Pujol-Muncunill, R., Martin-Sole, O., Rubio-Palau, J., Tarrado, X., Garcia-Aparicio, L., De Haro Jorge, I., Martin, A., Rojas-Ticona, J., Perez-Bertolez, S., Cuesta Argos, M., Capdevila Vilaro, B., Coronas Soucheiron, M., Riba Martinez, M., Saura Garcia, L., Prat Ortells, J., Bejarano Serrano, M., Parri, P., Massaguer, C., Vicario, F., Palazon Bellver, P., Moraleda Gudayol, I., Lara, A., Escobar, D., Arrieta, M., Garcia de cortazar, U., Villamor Garcia, I., Landaluce-olavarria, A., Gonzalez De miguel, M., Fernández Gómez Cruzado, L., Begoña, E., Lecumberri, D., Acosta Mérida, M. A., Yepes Cano, A. F., Estaire Gómez, M., Padilla-Valverde, D., Sánchez-García, S., Sanchez-Pelaez, D., Jimenez Higuera, E., Picón Rodríguez, R., Fernández Camuñas, À., Martínez-Pinedo, C., Garcia Santos, E. P., Muñoz-Atienza, V., Moreno Pérez, A., López de la Manzanara Cano, C. A., Ugarte-Sierra, B., Ibáñez-Aguirre, F. J., De Andres Olabarria, U., Fernández Pablos, F. J., Durán Ballesteros, M., Sanz Larrainzar, A., Jiménez Carneros, V., Valle Rubio, A., Alonso-Lamberti, L., García-Quijada, J., Leon, R., Rodriguez, J. L., Jimenez Miramón, J., Jover, J. M., Martín Salamanca, M. B., Assaf, M., Pérez Simón, V., Landeo Agüero, S. A., Baeza Pintado, N., Huertas Fernandez, M. A., Carabias, A., Sosa, M. V., Lora-Cumplido, P., Lanuza, L., Galipienso Eri, M., Garcia Montesino, J. D., Dellonder Frigolé, J., Noriego Muñoz, D., Navarro-Sánchez, A., Enjuto, D., Perez Gonzalez, M., Díaz Peña, P., Gonzalez, J., Marqueta De Salas, M., Martinez Pascual, P., Rodríguez Gómez, L., Garcés García, R., Ramos Bonilla, A., Herrera-Merino, N., Fernández Bernabé, P., Cagigal Ortega, E. P., Hernández, I., García de Castro Rubio, E., Cervera, I., Sánchez-Guillén, L., Fernández-Candela, A., Curtis-Martínez, C., Soler-Silva, Á., Oller, Á., Triguero-Cánovas, D., Bosch-Ramírez, M., Lillo, C., Lario, S., Arroyo, A., Espino Segura-Illa, M., Sánchez Aniceto, G., Castaño-Leon, A. M., Jimenez-Roldan, L., Delgado Fernandez, J., Pérez Núñez, A., Lagares, A., Garcia Perez, D., Santas, M., Paredes, I., Esteban Sinovas, O., Moreno-Gomez, L., Rubio, E., Vega, V., Vivas Lopez, A., Labalde Martinez, M., García Villar, O., Pelaéz Torres, P. M., Garcia-Borda, J., Ferrero Herrero, E., Gomez, P., Eiriz Fernandez, C., Ojeda-Thies, C., Pardo Garcia, J. M., Di Martino, M., De la Hoz Rodriguez, A., García Septiem, J., Maqueda González, R., Delgado Búrdalo, L., Correa Bonito, A., Martin-Perez, E., García Villayzán, J. E., Albi Martin, B., Lozano Lominchar, P., Martin, L., Fernadez, M., Rey-Valcarcel, C., Tousidonis, M., Martin-Albo Caballero, L., Lowy, A., Alonso Ortuño, P., Ayuso Herrera, E., Caño Velasco, J., Aragon-Chamizo, J., Perez Diaz, M. D., Mateo-Sierra, O., Quintana-Villamandos, B., Barrio, J. M., Fanjul, M., Sanchez- Perez, C., Fernandez, M. L., Hernandez-Kakauridze, S., Rio, J., Díaz Pérez, D., Serrano González, J., Colao García, L., Gutierrez Samaniego, M., Hernandez Bartolome, M. A., Galindo Jara, P., Esteban Agustí, E., Ripollés-Melchor, J., Abad-Motos, A., Abad-Gurumeta, A., Martínez-Hurtado, E., Ruiz-Escobar, A. B., Rogly, N., Guasch, E., Hernandez Gutierrez, A., Bartha Rasero, J. L., Perez, Y., Garcia-Pineda, V., Gracia, M., Siegrist Ridruejo, J., Diestro, M. D., Sanchez-Mendez, J. I., Marti, C., Melendez, M., Moreno-Palacios, E., Loayza, A., Frias, L., Zapardiel, I., Rubio-Perez, I., Prieto Nieto, M. I., Guevara, J., Gegundez Simon, A., Gortazar, S., Chavarrias, N., Alvarez, E., Saavedra, J., Ramos-Martin, P., Urbieta, A., Gomez Rivas, J., Toribio-Vázquez, C., Yebes, A., Hernández-García, M., Losada, M., Diéguez, B., García-Conde, M., Alonso Poza, A., Marquez, L., Becerra, R., Martin, M., Jorgensen, T., Muguerza, J. M., Dziakova, J., Sánchez del Pueblo, C., Saez Carlin, P., Camarero, E., Picazo, S., Pizarro, M. J., Avellana, R., Catalán, V., Lopez Antoñanzas, L., Cano, O., Anula, R., Sanz Lopez, R., Sanz Ortega, G., Garcia Alonso, M., Torres, A. J., Martin Antona, E., Garcia Botella, S., Ramos, D., Barranquero, A. G., Ocaña, J., Núñez, J., Cerro Zaballos, C., Crego-Vita, D., Huecas-Martinez, M., Diez Alonso, M., Mendoza-Moreno, F., Vera Mansilla, C., Ovejero Merino, E., Hernandez, P., Blazquez Martin, A., Ruiz Grande, F., Morales Palacios, N., Garcia-Loarte Gomez, E., Garca Rico, E., Minaya-Bravo, A. 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Benitez-Linero I., Manresa-Manresa F., Tallon-Aguilar L., Melero-Cortes L., Fernandez-Marin M.R., Duran-Munoz-Cruzado V.M., Ramallo-Solis I., Beltran-Miranda P., Pareja-Ciuro F., Anton-Eguia B.T., Oliva Mompean F., Gomez-Rosado J., Reguera-Rosal J., Valdes-Hernandez J., Capitan-Morales L., del Toro Lopez M.D., Achalandabaso Boira M., Memba Ikuga R., Abellan M., Sales R., Olona C., Jorba R., Hernandez Gutierrez J., Tebar Zamora A., Sancho-Muriel J., Cholewa H., Frasson M., Domenech J., Rosello Anon A., Sanguesa M.J., Moro-Valdezate D., Garces-Albir M., Lopez F., Bernal-Sprekelsen J.C., Catala Bauset J.C., Renovell Ferrer P., Martinez Perez C., Gil-Albarova O., Gilabert Estelles J., Aghababyan K., De Andres-Asenjo B., Beltran de Heredia J., Vazquez-Fernandez A., Ortiz de Solorzano-Aurusa F.J., Trujillo-Diaz J., Ruiz-Soriano M., Jezieniecki C., Gomez-Sanz T., Nunez-Del Barrio H., Romero-De Diego A., Garcia-Virto V., Aguado H.J., Fernandez Martin M.T., Tejero-Pintor F.J., Perez-Saborido B., Choolani Bhojwani E., Acebes Garcia F., Marcos-Santos P., Bueno Canones A.D., Sanchez Gonzalez J., Toledano M., Bailon M., Pacheco Sanchez D., Paniagua Garcia Senorans M., Sanchez-Santos R., Vazquez Melero A., Garcia D., Diez E., Herrero I., Soeda I.M., Camuera M., Balluerca M., Sanchez-Rubio M., Paunero Vazquez P., Martinez-German A., Gracia-Roche C., Gascon-Ferrer I., Duque-Mallen V., De Miguel-Ardevines M.D.C., Sanchez-Fuentes N., Santero-Ramirez M.S., Matute-Najarro M., Herrero-Lopez M., Cantalejo-Diaz M., Gonzalez-Nicolas-Trebol M.T., Saudi-Moro S., Jariod-Ferrer U.M., Rivas F., Escartin J., Blas Laina J.L., Nogues A., Cros B., Talal El-Abur I., Garcia Egea J., Yanez C., Ravindrakumar S., Rodrigo V.S.D., Arulanantham A., Bandara G.B.K.D., Hamid H.K.S., Ali E.E., Widatalla A.B.H., Bakheit I., Awadelkarim M., Ali karar A.A., Saleh M., Taflin H., Myrelid P., Amorim Braz L., Hagander L., Hambraeus M., Omling E., Salo M., Arkani S., Freedman J., Montan C., Lindqvist E.K., Elbe P., Hultgren R., Alga A., Nordberg M., Sandblom G., Holmner F., Lofgren N., Tampakis A., Kollmar O., von Fluee M., Balaphas A., Toso C., Colucci N., Popeskou S.G., Gass M., Scheiwiller A., Metzger J., Gialamas E., Chevallay M., Sauvain M., Dwidar O., Kiessling S.Y., Stoeckli S.J., Mongelli F., Bernasconi M., Di Giuseppe M., Christoforidis D., La Regina D., Arigoni M., Adamina M., Peros G., Guglielmetti L., Solimene F., Giardini M., Bachler T., Crugnale A.S., Gutschow C.A., Turina M., Ersen O., Onan M.A., Kozan R., Erol T., Dincer H.A., Yildiz A., Iflazoglu N., Yalkin O., Ozben V., Aytac E., Aliyeva Z., Akaydin E., Ozmen B.B., Baca B., Altinel Y., Calikoglu F., Tokocin M., Hacim N.A., Akbas A., Meric S., Vartanoglu T., Yigitbas H., Ercetin C., Ercan G., Ozgur I., Keskin M., Saracoglu K.T., Cimenoglu B., Demirhan R., Kale A., Simsek T., Gundogdu E.C., Abbasov A., Tanal M., Citgez B., Bozkurt E., Yetkin S.G., Mihmanli M., Alhamed A., Ergun S., Sanli A.N., Velidedeoglu M., OZcelik k M.F., Uludag S.S., Zengin A.K., Cebi S., Demirkiran F., Bese T., Acikgoz A.S., Kayan B., Aykanat Y., Mutlu D., Goksoy B., Kara Y., Bozkurt M.A., Kocatas A., Ogucu H., Uslu G., Arican C., Tugmen C., Aydin C., Yesilyurt D., Avci E.K., Kebapci E., Kilinc G., Sert I., Tuncer K., Akalin M., Emiroglu M., Demirli Atici S., Salimoglu S., Kaya T., Kirmizi Y., Tatar O.C., Yuksel E., Guler S.A., Yildirim A., Utkan N.Z., Gozal K., Koken H., Yabas A., Gonullu E., Altintoprak F., Akin E., Kamburoglu B., Capoglu R., Kucuk F., Demir H., Cakmak G., Firat N., Celebi F., Kocer B., Mantoglu B., Bayhan Z., Dikicier E., Colak E., Kucuk G.O., Karaman E., Kolusab A., Karaaslan O., Majid I., Abbas F., Abbas F.M.A., Mohammed D., Tahlak M.A., Yammahi A., Albaroudi A.A., Elyafawi B., Saber A., Khansaheb H., Alsaadi H., Alzarooni N., Bekheit M., Kamera B.S., Elhusseini M., Sharma P., Ahmeidat A., Cymes W., Hannah A., Mignot G., Shaikh S., Agilinko J., Angelou D., Neely D., McCanny A., McAree B., Baldwin A.J., West R., Gammeri E., Catton A., Marinos Kouris S., Pereca J., Singh J., Seymour Z., Jones R., Leeson S., Peevor R., Lala A.K., Houlden C., Kahiu J., Hossain N., Hosny S., Patel P., Handa S., Kaushal M., Kler A., Reghuram V., Tezas S., Fairhurst K., Yates C., Mitchell S., Bunni J., Richards S., George R., Lee S.M., Phull J., Frost J., Burnard S., Crowley R., Airey A., Bevan K., Makin-Taylor R., Ong C.S., Callan R., Bloom O., Aljanadi F., Moawad N., Jones M., Gregg A., Jeganathan R., Pachl M., Martin B., Archer J.E., Odeh A., Siddaiah N., Singhal R., Naumann D.N., Karandikar S., Syed A., Tucker O.N., Alam R., Kalkat M., Mak J.K.C., Kulkarni R., Sharma N., Nankivell P., Tirotta F., Parente A., Breik O., Kisiel A., Cato L.D., Saeed S., Pathanki A.M., Almond M., Kamal M., Leung E.Y.L., Kaur R., Brett-Miller C., Buruiana F.E., Markose G., De Gea Rico A., Taib A., Myatt D., Sulaiman Khaled A., Younis F., Sultana A., Taggarsi M., Vitone L., Lambert J., Vaz O.P., Sarantitis I., Shrestha D., Timbrell S., Shugaba A., Quddus B., Law J., Bittar M.N., Creanga M., Elniel M., Youssef M., Ali S., Qadri S.T., Brixton G., Findlay L., Klatte T., Majkowska A., Manson J., Potter R., Oktseloglou V., Mosley F., De La Cruz Monroy M.F.I., Bobak P., Omar I., Ahad S., Langlands F., Brown V., Hashem M., Kennedy L., Jaunoo S., Coomber E., Williams O., Rhodes H.L., Williams A., Ridgway A., Pournaras D., Britton E., Lostis E., Ambler G.K., Chu H., Hopkins J., Manara J., Chan M., Doe M., Moon R.D.C., Jichi T., Singleton W., Main B., Maccabe T., Newton C., Blencowe N.S., Fudulu D.P., Bhojwani D., Baquedano M., Caputo M., Rapetto F., Flannery O., Hassan A., Coonar A., Aresu G., Smith C., Gearon D., Hogan J., Pradeep I.S., Durio Yates H., Peryt A., Barrett-Brown Z.M., King M., Ahmadi N., Jenkins D., Moorjani N., Taghavi F., Wells F., Hardie J., Page S., Anazor F., King S.D., Luck J., Kazzaz S., Mannion R., Stewart G.D., Ramzi J., Mohan M., Singh A.A., Ashcroft J., Baker O.J., Coughlin P., Davies R.J., Durst A.Z.E.D., Abood A., Habeeb A., Hudson V.E., Lamb B., Luke L., Mitrasinovic S., Murphy S., Ngu A.W.T., O'Neill J.R., Waseem S., Wong K., Georgiades F., Hutchinson P.J., Tan X.S., Pushpa-rajah J., Colquhoun A., Masterson L., Abu-Nayla I., Walker C., Balakrishnan A., Rooney S., Irune E., Byrne M.H.V., Durrani A., Simoes A., Eddy B., Streeter E., Ahmed I., Yao M., Wang W., Djouani A., Tait-Bailey J., Thomas M., Hassan F., Kommu S., Chopra S., Richards T., Sethuraman Venkatesan A., Combellack T., Williams J., Tahhan G., Mohammed M., Kornaszewska M., Valtzoglou V., Deglurkar I., Rahman M., Von Oppell U., Mehta D., Koutentakis M., Syed Nong Chek S.A.H., Hill G., Morris C., Shinkwin M., Torkington J., Cornish J., Houston R., Mannan S., Ayeni F., Tustin H., Bordenave M., Robson A., Dovell G., Preece R., Rolland P., Miranda B.H., Sobti A., Khaleel A., Unnithan A., Memon K., Pala Bhaskar R.R., Maqboul F., Kamel F., Al-Samaraee A., Madani R., Kumar L., Nisar P., Agrawal S., Vimalachandran D., Manu N., Eardley N., Krishnan E., Serevina O.L., Martin E., Jones A., Roy Mahapatra S., Clifford R., Jones G.P., Gardner A., Tripathi S.S., Greenhalgh M.S., Matthews W., Mohankumar K., Khawaja I., Palepa A., Doulias T., Gill C., Dunne N., Sarma D.R., Godbole C., Carlos W., Tewari N., Jeevan D., Naredla P., Khajuria A., Connolly H., Robertson S., Sweeney C., Di Taranto G., Shanbhag S., Dickson K., McEvoy K., Skillman J., Sait M., Al-omishy H., Baig M., Heer B., Brown A., Ebrahim A., Alwadiya A., Goyal A., Phillips A., Bhalla A., Demetriou C., Grimley E., Theophilidou E., Ogden E., Malcolm F.L., Davies-Jones G., Ng J.C.K., Mirza M., Hassan M., Elmaleh N., Daliya P., Williams S., Bateman A., Chia Z., Premakumar Y., Jauhari Y., Koshnow Z., Bowen D., Uberai A., Hirri F., Stubbs B.M., Crichton R., Sonksen J., Aldridge K., McDonald C., Manickavasagam J., Ragupathy K., Davison S., Dalgleish S., McGrath N., Kanitkar R., Payne C.J., Ramsay L., Ng C.E., Collier T., Khan K., Evans R., Brennan C., Henshall D.E., Drake T., Harrison E.M., Zamvar V., Tambyraja A., Skipworth R.J.E., Linder G., McGregor R., Brennan P., Mayes J., Ross L., Smith S., White T., Jamjoom A.A.B., Pasricha R., Gallagher K., Swan R., Paterson H., Maeda Y., Kwok A.M.F., Tsiaousidou A., Vaughan-Shaw P.G., Boyle C., Fernando D., Tham D., Leung S., Laird A., Holme T., Abbott S., Razik A., Thrumurthy S., Steinke J., Baker M., Howden D., Baxter Z., Osagie L., Bence M., Fowler G.E., Massey L., Rajaretnam N., Evans J., John J., Goubran A., Campain N., McDermott F.D., McGrath J.S., Ng M., Pascoe J., Phillips J.R.A., Daniels I.R., A'Court J., Konarski A., Faulkner G., Emerson H., Vejsbjerg K., Pearce L., McCormick W., Fisher A., Singisetti K., Aawsaj Y., Bajomo O., Rizvi S., Grimes C., Dusu K., Tint P.Y., Kirk A., Irvine V., Lammy S., O'Kane R., Elliott L., Mccabe G., Holroyd D., Jamieson N.B., Geddes A., McMahon J., McCaul J., Al-Azzawi M., Aitken E., Glen P., Sinan L.O.H., Grivas A., Tilling E.J., Brown O., Boal M., Dean H., Higgs S., Stanger S., Abdalaziz H., Constable J., Ishii H., Gopi reddy R., Madhuri T.K., Tailor A., Flavin M., Walker D., Humphries S., Assalaarachchi H., Curl-Roper T., Westwood E., Delimpalta C., Liao C.C.L., Velchuru V., Raptis D.A., Pollok J.M., Machairas N., Davidson B., Fusai G., Soggiu F., Xyda S., Hidalgo Salinas C., Tzerbinis H., Pissanou T., Gilliland J., Varcada M., Hart C., Mirnezami R., Knowles J., Angamuthu N., Vijay V., Shakir T., Hasan R., Tansey R., Hardie C., Powell-Smith E., Kashora F., Siddique M.H., Singh A., Barmpagianni C., Basgaran A., Basha A., Okechukwu V., Bartsch A., Gallagher P., Maqsood A., Sahnan K., Leo C.A., Lewis S.E., Ubhi H.K., Exley R., Khan U., Shah P., Saxena S., Zafar N., Abdul-Jabar H., Patel M., Shabana A., Alanbuki A., Usman O., Ong C.T., Butterworth W., Budha Magar O., El Hadi M., Abas S., Annett J., Ross E., Loubani M., Wilkins A., Cao H., Capitelli-McMahon H., Hitchman L., Ikram H., Andronic A., Aboelkassem Ibrahim A., Totty J., Blanco J., Vanker R., Ghobrial M., Jones G., Kanthasamy S., Fawi H., Awadallah M., Chen F., Cheung J., Moscalu A., Bhuvanakrishna T., Bibby L., Sinclair M., Nahid M.A.K., Williams L., Basnyat P.S., Shrestha A.K., Kumaran N.K., Sambhwani S., Sheikh N.A., Taylor O.M., Liew I., Al-Sukaini A., Mediratta S., Saxena D., Sgro A., Rashid M.M., Milne K., McIntyre J., Akhtar M.A., Turnbull A., Brunt A., Stewart K.E., Wilson M.S.J., Rutherford D., McGivern K., Massie E., Ho M., Wade R.G., Johnstone J., Bourke G., Brunelli A., Elkadi H., Otify M., Pompili C., Burke J.R., Bagouri E., Chowdhury M., Abual-Rub Z., Kaufmann A., Munot S., Lo T., Young A., Kowal M., Wall J., Peckham-Cooper A., Layton G.R., Karki B., Jeong H., Pankhania S., Asher S., Folorunso A., Mistry S., Singh B., Winyard J., Mangwani J., Mohammad A., Acharya M., Chandarana K., Ang K., Chowdhry M.F., Rathinam S., Nakas A., Boddy A., Hossain T., Ashmore C., Annamalai S., Kourdouli A., Irvine E., Al-Harbawi A., Kassam K., Al-Harbawee A., Miller A., Mair M., Lunevicius R., Sheel A.R.G., Sundhu M., Santini A.J.A., Fathelbab M.S.A.T., Hussein K.M.A., Nunes Q.M., Jones R.P., Shahzad K., Haq I., Baig M.M.A.S., Hughes J.L., Kattakayam A., Rajput K., Misra N., Shah S.B., Clynch A.L., Georgopoulou N., Sharples H.M., Apampa A.A., Nzenwa I.C., Sud A., Harky A., Kirmani B.H., Shackcloth M., Zakaria R., Elmoslemany T., Millward C.P., Baron R., Dunne D., Szatmary P., Thomas A., McNicol F., Gahunia S., Sochorova D., Nita G.E., McKinney R., Russ J., Tan J.R., Harwood R., Corbett H.J., Rossborough C., Skelly B.L., Che Bakri N.A., Nazarian S., Vashisht R., Jiao L., Jawad Z., Allan A.Y., Kontovounisios C., Grove T., Warren O., Fadel M.G., Chatzikonstantinou M., Sorelli P., Rahman S., Hadjipavlou M., Holbrook C., Chong C., Kufeji D., Rufai S.R., Lloyd I.C., James G., Chari A., Silva A.H.D., Stroman L., Challacombe B., Sayasneh A., Najdy M., Bille A., Fraser S., Agoston P., Rizzo V., King J., Nath R., McCrindle S., Mehra G., Harrison-Phipps K., Pilling J., Okiror L., Routledge T., Mills L., Wali A., El-Boghdadly K., Saso S., Fehervari M., Ploski J., Ghaem-Maghami S., Spalding D., Rajagopal P., Pai M., Habib N., Hamrang-Yousefi S., Tayeh S., Chase T., Humphreys L., Ayorinde J., Ghanbari A., Cuming T., Anscomb N., Baldwin-Smith R., Rizk M., Grainger C., Davies M., Surendran A., Nunoo-Mensah J.W., Dunstan M., Beak P., Gerogiannis I., Jain A., Menon A., Pramodana B., Choi D., Marcus H.J., Webber L., May R., Hutchison R., Luoma V., Ranjit S., Parakh J., Sarodaya V., Daadipour A., Khalifa M., Bosch K.D., Bashkirova V., Dvorkin L.S., Kalidindi V.K., Dudek J., Singhal T., El-Hasani S., De Souza A., Cannoletta M., Rochon M., Bhudia S., Bennett S., Navaratne L., Venn M., Yip V., Kayani B., Sohrabi C., Kocher H.M., Minicozzi A., Banerjee A., Sullivan T., Sivaprakasam R., Anzak A., Ghufoor K., Thaha M.A., Knowles C., Ledesma F.S., Patki P., Popova D., Sadigh P., Ramamoorthy R., Uff C., Attwell L., Tanabalan C., Goh M.A., Jayasinghe J.D., Leal Silva I., Thakur B., Lebe M., Thet M.S., Hughes F., Rahman R., Fuwa O., Oo A., Bueser T., Curtis M., Stamenkovic S.A., Abbott T., Anwar S., Williams K., Chung E., Hagger R., Karim A., Hainsworth A., Flatman M., Trompeter A., Hing C., Tsinaslanidis P., Benjamin M.W., Leyte A., Tan C., Smelt J., Vaughan P., Santhirakumaran G., Hunt I., Raza M., Labib A., Luo X., Sudarsanam A., Rolls A., Lyons O., Onida S., Shalhoub J., Sugand K., Park C., Sarraf K.M., Erridge S., Kinross J., Denning M., Yalamanchili S., Abuown A., Ibrahim M., Martin G., Davenport D., Wheatstone S., Kasivisvanathan V., Kapriniotis K., Elhamshary A., Imam S.M.B., Kalavrezos N., Sinha D., Chand M., Green L., Beech N., McEwen R., Kiconco H., Andreani S.M., Bath M.F., Sahni A., Judkins N., Rigueros Springford L., Bacarese-Hamilton J., Taylor F.G., Parmar C., Mccluney S., Shah S., Talwar R., Patel K., Askari A., Jambulingam P.S., Shaw S., Maity A., Hatzantonis C., Sagar J., Kudchadkar S., Cirocchi N., Chan C.H., Reynolds J., Alexander M.E., Smart C.J., Jayasankar B., Balasubramaniam D., Abdelsaid K., Mundkur N., Gallagher B., Shah J., Anthoney J., Emmerson O., Stylianides N., Abdalla M., Newton K., Bhatia K., Edmondson R., Abdeh L., Jones D., Zeiton M., Ismail O., Naseem H., Advani R., Duff S., Moura F., Brown B.C., Khan A., Asaad P., Wadham B., Aneke I.A., Collis J., Warburton H., Fell A., Smith A., Halkias C., Nikolaou S., English C., Kristinsson S., Oni T., Ilahi N., Ballantyne K., Woodward Z., Merh R., Dunning J., Viswanath Y., Freystaetter K., Dixon J., Hadfield J.N., Hilley A., Egglestone A., Smith B., Hine T., Keeler B., Soulsby R.E., Taylor A., Davies E., Ryska O., Raymond T., Rogers S., Tong A., Hawkin P., Tingle S., Abbadessa F., Sachdeva A., Rai B., Chan C.D., McPherson I., Booth K., Mahmoud Ali F., Pandanaboyana S., Grainger T., Nandhra S., Patience A., Roy C., Williams T., Dawe N., McCaffer C., Riches J., Bhattacharya S., Moir J., Kalson N.S., Elamin Ahmed H., Mellor C., Saleh C., Koshy R.M., Hammond J., Sanderson L., Wahed S., Phillips A.W., Ghosh K., Tang A., Beamish A.J., Price C., Bosanquet D., Magowan D., Solari F., Williams G., Nassa H., Smith L., Robertson-Smith B., Mahmoud A., Ameerally P., Finch J.G., Gnanachandran C., Pop I., Rogers M., Yousef Y., Mohamed I., Woods R., Zahid H., Mundy G., Sreedharan L., Baskaran D., Shaikh I., Seebah K., Reid J., Watts D., Kouritas V., Chrastek D., Maryan G., Gill D.F., Khatun F., Gajjar K., Williamson K., Bratt D., Konstantinidi K., Walton T., Burnside N., Weaver H., Hawari M., Addae-Boateng E., Rollett R.A., Collins M.L., Tamimy M.S., Riyat H., Wen J., Neil-Dwyer J., Brewer H., Humes D., Worku D., Chowdhury A., Oyende O., Lewis-Lloyd C., Adiamah A., Koh A., Jackman J., Vohra R., Navarro A., Reilly J., Aujayeb A., Townshend D., McLarty N., Shenfine A., Jackson K., Johnson C., Dass D., Ford D., Winter S.C., Belcher E., Stavroulias D., Di Chiara F., Wallwork K., Qureishi A., Lami M., Sravanam S., Mastoridis S., Shah K., Chidambaram S., Smillie R., Shaw A.V., Bandyopadhyay S., Cernei C., Bretherton C., Jeyaretna D., Ganau M., Piper R.J., Duck E., Brown S., Jelley C., Tucker S.C., Bond-Smith G., Griffin X.L., Tebala G.D., Neal N., Vatish M., Noton T.M., Ghattaura H., Maher M., Fu H., Risk O.B.F., Soleymani majd H., Sinha S., Shankar S., Aggarwal A., Kharkar H., Lakhoo K., Verberne C., Dean B., Luney C., Myatt R., Williams M.A., McVeigh J., Labib P.L., Miller D., Minto G., Hope N., Marchbank A., Emslie K., Panahi P., Ho B., Perkins C., Clough E., Roy H., Enemosah I., Campbell R., Natale J., Gohil K., Rela M., Raza N., Biliatis I., Khan J., Thiruchandran G., Toh S.K.C., Ahmad Y., Allana A., Bellis C., Babawale O., Phan Y.C., Lokman U., Ismail M., Koc T., Witek A., Duggleby L., Shamoon S., Stefan S., Clancy H., Chadha R., Middleton S.B., Wilmott K., Hayden C., Mclaren C., Sutton J., Whyte A., Belgaumkar A., Day A., Gilbert C., Oyewole B., Narayan P., Dent H., Sandhya A., De Silva T., Waheed S., Kapoor K., Belgaumkar A.P., Fahim M., Gala T., Mithany R., Morgan R., Abdelkarim M., Maw A., Asqalan A., Sundaram Venkatesan G., Singh S., Mukherjee S., Ferguson D., Mansuri A., Thakrar A., Wickramarachchi L., Cuthbert R., Sivayoganathan S., Chui K., Karam E., Dott C., Madhvani K., Hampton M., Hormis A.P., Fountain D.M., Laurente R., Sigamoney K.V., Dasa M., George K., Naqui Z., Galhoum M., Lipede C., Gabr A., Radhakrishnan A., Hasan M.T., Kalenderov R., Pathmanaban O., Chelva R., Branagan G., Longstaff L., Ding D., Barlow C., Foster J., Ward A., Tadross D., Majkowski L., Blundell C., Nair R., Guha S., Brown S.R., Steele C., Kelty C.J., Newman T., Lee M., Lye G., Balasubramanian S.P., Sureshkumar Shah N., Sherif M., Al-mukhtar A., Whitehall E., Giblin A., Sharkey A., Adamec A., Madan S., Narice B., Sterrenburg M., Thompson A., Varley I., Stavrakas M., Rominiyi O., Ray J., Crank M., Bacon A., Al-Tamimi Y., Catto J., Saad S., Abd Kahar N.N., Sou A., Simpson D., Hamilton E., Blair J., Jallad S., Lord J., Anderson C., El Kafsi J., Logishetty K., Saadya A., Midha R., Ip M., Subbiah Ponniah H., Stockdale T., Bacarese-Hamilton T., Foster L., James A., Anjarwalla N., Marujo Henriques D., Hettige R., Baban C., Tenovici A., Salerno G., Lane J., Colvin H.V., Badran A., Cadersa A., Cumpstey A., Hamady Z., Aftab R., Wensley F., Byrne J., Morrison-Jones V., Sekhon G.K., Shields H., Shakoor Z., Yener A., Talbot T., Alzetani A., Cresner R., Babu B.H.B., Liyanage A.S.D., Newman S., Blake I., Weerasinghe C., Baumber R., Parry J., Menakaya C., Webb J.I., Antar M., Modi N., Sofat R., Noel J., Nunn R., Adegbola S., Eriberto F., Sharma V., Tanna R., Lodhia S., Johnson D., Hughes I., Hall J., Rooney J., Chatterji S., Zhang Y., Owen R., Rudic M., Hunt J., Zakai D., Aladeojebi A., Ali M., Gaunt A., Barmayehvar B., Kitchen M., Gowda M., Mansour F., Jarvis M., Halliday E., Lefroy R., Nanjaiah P., Lin D.J., Rajgor A.D., Scurrah R.J., Kang C., Watson L.J., Harris G., Royle T., Cunningham Y., Steel B., Luk A.C.O., Boulton A.J., Bakolas G., Herrod P., Gemmill E., Boyd-Carson H., Jibreel M., Lenzi E., Saafan T., Sapre D., Li Z., Parkins K., Spencer N., Harries R., Egan R.J., Motter D., Jenvey C., Mahoney R., Fine N., Minto T., Henry A., Hollyman M., Grieco C., Gemmell C., Whitmore H., Babar M.S., Goodrum S., Scott R., Collard B., Lau K., Thomas E., Patel A., Allison J., Bowen J., Dias A., Mahendran B., Gopalswamy S., Patil S., Scott L., Sarveswaran J., Michel M., Ravindran S., Subba K., Abou-Foul A.K., Khalefa M., Hossain F., Moores T., Pickering L., Stables G., Doorgakant A., Thiruvasagam V.G., Carter J., Reid S., Mohammed R., Marlow W., Ferguson H., Wilkin R., Konstantinou C., Yershov D., Vatish J., Denning A., Shah H.B., Cross G.W.V., Seyed-Safi P., Smart Y.W., Kuc A., Al-Yaseen M., Olivier J., Hanna M., Eskander P., Duncan R., Halaseh S., Das R., Wynn Jones H., Divecha H., Whelton C., Board T., Powell S., Magee C., Agarwal K., Mangos E., Nambirajan T., Vidya R., Chauhan G., Kaur J., Burahee A., Bleibleh S., Pigadas N., Snee D., Bhasin S., Crichton A., Habeebullah A., Bodla A.S., Yassin N., Mondragon M., Dewan V., Flindall I., Mahendran V., Hanson A., Jenner E., Richards J., Thomas-Fernandez K., Wall R., Alqallaf A., Ben-Sassi A., Mellor K., Joshi P., Joshi Y., Young R., Miu V., Sheridan K., MacDonald L., Green S., Onos L., Wong J.J., Napolitano L., Hemmila M., Amin D., Abramowicz S., Roser S.M., Olson K.A., Riley C., Heron C., Cardenas T., Leede E., Thornhill M., Haynes A.B., McElhinney K., Roward S., Trust M.D., Hill C.E., Teixeira P.G., Etchill E., Stevens K., Ladd M.R., Long C., Rose J., Kent A., Yesantharao P., Vervoort D., Jenny H., Gabre-Kidan A., Margalit A., Tsai L., Malapati H., Yesantharao L., Abdou H., Diaz J., Richmond M., Clark J., O'Meara L., Hanna N., Ying Y., Fleming J., Ovaitt A., Gigliotti J., Fuson A., Cooper Z., Salim A., Hirji S.A., Chung C., Hansen L., Okafor B.U., Roxo V., Raut C.P., Jolissaint J.S., Mahvi D.A., Bankhead-Kendall B., Velmahos G., Maurer L.R., El Moheb M., Gaitanidis A., Naar L., Christensen M.A., Kapoen C., Langeveld K., El Hechi M., Mokhtari A., Haqqani M.H., Drake F.T., Goldenberg-Sandau A., Galbreath B., Reinke C., Ross S., Thompson K., Manning D., Perkins R., Eriksson E., Evans H., Masrur M., Giulianotti P., Benedetti E., Chang G., Ourieff J., Dehart D., Dorafshar A., Price T., Bhama A.R., Torquati A., Cherullo E., Kennedy R., Myers J., Rubin K., Ban V.S., Aoun S.G., Batjer H.H., Caruso J., Carmichael H., Velopulos C.G., Wright F.L., Urban S., McIntyre R.C., Schroeppel T.J., Hennessy E.A., Dunn J., Zier L., Burlew C., Coleman J., Colling K.P., Hall B., Rice H.E., Hwang E.S., Olson S.A., Moris D., Verma R., Hassan R., Volpe A., Merola S., O'Banion L.A., Lilienstein J., Dirks R., Marwan H., Almasri M., Kulkarni G., Mehdi M., Abouassi A., Abdallah M., San Andres M., Eid J., Aigbivbalu E., Sundaresan J., George B., Ssentongo A., Ssentongo P., Oh J.S., Hazelton J., Maines J., Gusani N., Garner M., Horvath S., Zheng F., Ujiki M., Kinnaman G., Meagher A., Sharma I., Holler E., McKenzie K., Chan J., Fretwell K., Nugent W., Khalil A., Chen D., Post N., Rostkowski T., Brahmbhatt D., Huynh K., Hibbard M.L., Schellenberg M., Martin R.C.G., Bhutiani N., Giorgakis E., Laryea J., Bhavaraju A., Sexton K., Kost M., Kimbrough M., Burdine L., Kalkwarf K., Robertson R., Gosain A., Camp L., Lewit R., Kronenfeld J.P., Urrechaga E., Goel N., Rattan R., Hart V., Gilna G., Cioci A., Ruiz G., Rakoczy K., Pavlis W., Saberi R., Morris R., Karam B.S., Brathwaite C.E.M., Liu H., Petrone P., Hakmi H., Sohail A.H., Baltazar G., Heckburn R., Nygaard R.M., Colonna E.T., Endorf F.W., Hill M.J., Maiga A., Dennis B., Levin J.H., Lallemand M., Choron R., Peck G., Soliman F., Rehman S., Glass N., Juthani B., Deisher D., Ruzgar N.M., Ullrich S.J., Sion M., Paranjape C., Kar A.R., Gillezeau C., Rapp J., Taioli E., Miles B.A., Alpert N., Podolsky D., Coleman N.L., Callahan M.P., Brown L., Monson J.R.T., Dehal A., Abbas A., Soliman A., Kim B., Jones C Dauer M.D.E., Renza-Stingone E., Hernandez E., Gokcen E., Kropf E., Sufrin H., Hirsch H., Ross H., Engel J., Sewards J., Poggio J., Sanserino K., Rae L., Philp M., Metro M., McNelis P., Petrov R., Pazionis T., Till B., Lamm R., Rios-Diaz A.J., Palazzo F., Rosengart M., Nicholson K., Carrick M.M., Rodkey K., Suri A., Callcut R., Nicholson S., Talathoti N., Klaristenfeld D., Biffl W., Marsh C., Schaffer K., Berndtson A.E., Averbach S., Curry T., Kwan-Feinberg R., Consorti E., Gonzalez R., Grolman R., Liu T., Merzlikin O., Abel M.K., Ozgediz D., Boeck M., Kornblith L.Z., Nunez-Garcia B., Robinson B., Park P., Utria A.F., Rice-Townsend S.E., Javid P., Hauptman J., Kieran K., Nehra D., Walters A., Cuschieri J., Davidson G.H., Cosker R., Eckhouse S., Choudhry A., Marx W., Jamil T., Seegert S., Al-Embideen S., Quintana M., Jackson H., Wexner S.D., Kent I., Martins P.N., Alshehari M., Al-Naggar H., Alsayadi M., Alyazidi M., Shream S., Alhaddad W., Maqus A., Abu Hamra'a M., Alsayadi R., Ghannam R., Al-Maqtari S., Masdoos S., Al-Harazi Y., Bajjah H., Al-ameri S., Aldawbali M., Gwini G.P., Collaborative, Cardiothoracic Interdisciplinary Research Network and COVIDSurg, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The Cardiothoracic Interdisciplinary Research Network and COVIDSurg Collaborative, Akowuah, E, Benson, R, Caruana, E, Chetty, G, Edwards, J, Forlani, S, Gradinariu, G, Murphy, G, Oo, A, Patel, A, Ridley, B, Rogers, L, Sanders, J, Tyson, N, Vaja, R, Siaw-Acheampong, K, Argus, L, Chaudhry, D, Dawson, B, Glasbey, J, Gujjuri, R, Jones, C, Kamarajah, S, Khatri, C, Keatley, J, Lawday, S, Li, E, Mann, H, Marson, E, Mclean, K, Picciochi, M, Taylor, E, Tiwari, A, Simoes, J, Trout, I, Venn, M, Wilkin, R, Bhangu, A, Nepogodiev, D, Dajti, I, Gjata, A, Boccalatte, L, Modolo, M, Cox, D, Pockney, P, Townend, P, Aigner, F, Kronberger, I, Hossain, K, Vanramshorst, G, Lawani, I, Ataide, G, Baiocchi, G, Buarque, I, Gohar, M, Slavchev, M, Agarwal, A, Brar, A, Martin, J, Olivos, M, Calvache, J, Perez Rivera, C, Hadzibegovic, A, Kopjar, T, Mihanovic, J, Klat, J, Novysedlak, R, Christensen, P, El-Hussuna, A, Batista, S, Lincango, E, Emile, S, Mengesha, M, Hailu, D, Tamiru, H, Kauppila, J, Laukkarinen, J, Arnaud, A, Albertsmeiers, M, Lederhuber, H, Loffler, M, Tabiri, S, Metallidis, S, Tsoulfas, G, Lorena, M, Grecinos, G, Mersich, T, Wettstein, D, Ghosh, D, Kembuan, G, Brouk, P, Khosravi, M, Mozafari, M, Adil, A, Mohan, H, Zmora, O, Fiore, M, Gallo, G, Pata, F, Pellino, G, Satoi, S, Ayasra, F, Chaar, M, Fakhradiyev, I, Jamal, M, Elhadi, M, Gulla, A, Roslani, A, Martinez, L, Ramos De La Medina, A, Outani, O, Jonker, P, Kruijff, S, Noltes, M, Steinkamp, P, van der Plas, W, Ademuyiwa, A, Osinaike, B, Seyi-olajide, J, Williams, E, Pejkova, S, Augestad, K, Soreide, K, Al Balushi, Z, Qureshi, A, Sayyed, R, Mohsen Daraghmeh, M, Abukhalaf, S, Cukier, M, Gomez, H, Shu, S, Vasquez, X, Parreno-Sacdalan, M, Major, P, Azevedo, J, Cunha, M, Santos, I, Zarour, A, Bonci, E, Negoi, I, Efetov, S, Litvin, A, Ntirenganya, F, Alameer, E, Radenkovic, D, Hong Xiang, F, Hoe, C, Chi Yong, J, Moore, R, Nhlabathi, N, Colino, R, Bravo, A, Minaya-Bravo, A, Jayarajah, U, Wickramasinghe, D, Elmujtaba, M, Jebril, W, Rutegard, M, Sund, M, Isik, A, Leventoglu, S, Abbott, T, Caruna, E, Chakrabortee, S, Demetriades, A, Desai, A, Drake, T, Evans, J, Ford, S, Fotopoulou, C, Griffiths, E, Hutchinson, P, Jenkinson, M, Khan, T, Knight, S, Kolias, A, Leung, E, Mckay, S, Norman, L, Ots, R, Raghavan, V, Roberts, K, Schache, A, Shaw, R, Shaw, K, Smart, N, Stewart, G, Sundar, S, Vimalchandran, D, Wright, N, Alshryda, S, Alser, O, Breen, K, Ganly, I, Kaafarani, H, Kendall, B, Mashbari, H, Al Naggar, H, Mazingi, D, Valenzuela, J, Gemelli, N, Smith, D, Dudi-Venkata, N, Kroon, H, Sammour, T, Roberts, M, Mitchell, D, Lah, K, Pearce, A, Morton, A, Dawson, A, Drane, A, Sharpin, C, Nataraja, R, Pacilli, M, Muralidharan, V, Riddiough, G, Clarke, E, Jamel, W, Qin, K, Cope, D, Egoroff, N, Lott, N, Putnis, S, De Robles, S, Ang, Z, Mitteregger, M, Uranitsch, S, Stiegler, M, Seitinger, G, Lumenta, D, Nischwitz, S, Richtig, E, Pau, M, Srekl-Filzmaier, P, Eibinger, N, Michelitsch, B, Fediuk, M, Papinutti, A, Seidel, G, Kahn, J, Cohnert, T, Messner, F, Ofner, D, Presl, J, Varga, M, Weitzendorfer, M, Emmanuel, K, Binder, A, Zimmermann, M, Holawe, S, Nkenke, E, Grimm, C, Kranawetter, M, Rahman Mitul, A, Islam, N, Karim, S, Komen, N, Ang, E, De Praetere, H, Tollens, T, Schols, G, Smets, C, Haenen, L, Quintens, J, Van Belle, K, Van Ramshorst, G, Pattyn, P, Desender, L, Martens, T, Van de putte, D, Lerut, P, Grimonprez, A, Janssen, M, De Smul, G, Wallaert, P, Van den Eynde, J, Oosterlinck, W, Van den Eynde, R, Sermon, A, Boeckxstaens, A, Cordonnier, A, De Coster, J, Jaekers, J, Politis, C, Miserez, M, Duchateau, N, De Gheldere, C, Flamey, N, Christiano, A, Guidi, B, Minussi, A, Castro, S, Okoba, W, Maldonado, F, Oliveira, P, Baldasso, T, Santos, L, Gomes, G, Pol-Fachin, L, Bezerra, T, Barros, A, da Silva, A, Leite, A, Silvestre, D, Ferro, C, Araujo, M, Lopes, L, Damasceno, P, Araujo, D, Laporte, G, Salem, M, Guimaraes-Filho, M, Nacif, L, Flumignan, R, Nakano, L, Kuramoto, D, Aidar, A, Pereda, M, Correia, R, Santos, B, Carvalho, A, Amorim, J, Guedes Neto, H, Areias, L, Sousa, A, Flumignan, C, Lustre, W, Moreno, D, Barros, N, Baptista-Silva, J, Matos, L, Kowaski, L, Kulcsar, M, Nunes, K, Teixeira, M, Nunes, R, Ijichi, T, Kim, N, Marreiro, A, Muller, B, Barakat Awada, J, Kowalski, L, Vartanian, J, Makdissi, F, Aguiar, S, Marques, N, Carvalho, G, Marques, T, Abdallah, E, Zurstrassen, C, Gross, J, Zequi, S, Goncalves, B, Santos, S, Duprat, J, Coimbra, F, Cicco, R, Takeda, F, Cecconello, I, Ribeiro, U, Gatti, A, Oliva, R, Nardi, C, Atanasov, B, Belev, N, Dell, A, Bigam, D, Dajani, K, Al Riyami, S, Cheng, D, Yang, H, Fayad, A, Carrier, F, Amzallag, E, Desroches, J, Ruel, M, Caminsky, N, Boutros, M, Moon, J, Wong, E, Vanounou, T, Pelletier, J, Wong, S, Girsowicz, E, Bayne, J, Obrand, D, Gill, H, Steinmetz, O, Mackenzie, K, Lukaszewski, M, Jamjoum, G, Richebe, P, Verdonck, O, Discepola, S, Godin, N, Idrissi, M, Briatico, D, Sharma, S, Talwar, G, Bailey, K, Lecluyse, V, Cote, G, Demyttenaere, S, Garfinkle, R, Kouyoumdjian, A, Dumitra, S, Khwaja, K, Luo, L, Berry, G, Liberman, A, Schmid, S, Spicer, J, Al Farsi, M, Abou-Khalil, J, Couture, E, Mohammadi, S, Tremblay, H, Gagne, N, Bergeron, A, Turgeon, A, Costerousse, O, Bellemare, D, Babin, C, Blier, C, Wood, M, Persad, A, Groot, G, Pham, H, D'Aragon, F, Carbonneau, E, Bouchard, M, Masse, M, Pesant, F, Heroux, J, Karanicolas, P, Hallet, J, Nadler, A, Nathens, A, Ko, M, Mayson, K, Kidane, B, Srinathan, S, Escudero, M, Reyes, J, Ramirez Nieto, P, Sepulveda, R, Bolbaran, A, Molero, A, Ruiz, I, Reyes, G, Salas, R, Suazo, C, Munoz, R, Grasset, E, Inzunza, M, Besser, N, Irarrazaval, M, Jarry, C, Bellolio, F, Romero Manqui, C, Ruiz Esquide, M, Fuentes, T, Campos, J, Cabrera, P, Pinilla, R, Guevara, O, Jimenez Ramirez, L, Velasquez Cuasquen, B, Herrera Mora, D, Bonilla, A, Diaz, S, Manrique, E, Facundo, H, Velez Bernal, J, Angel, J, Garcia, M, Guzman, L, Lehmann, C, Cervera, S, Trujillo Sanchez, L, Guevara, R, Valbuena, D, Suarez, L, Jimenez, G, Velandia, A, Vargas, J, Espinosa, J, Rey, S, Mendoza Quevedo, J, Orozco-Chamorro, C, Sanchez-Gomez, T, Rojas-Tejada, D, Bakmaz, B, Rakvin, I, Sulen, N, Andabaka, T, Luksic, I, Mamic, M, Martinek, L, Skrovina, M, Zatecky, J, Peteja, M, Kristensen, H, Mekhael, M, Westh, L, Smith, H, Haugstvedt, A, Jonsson, M, Crespo, A, Rodriguez-Abreu, J, Tactuk, N, Diaz-Delgado, P, Rivas, R, Sarmiento-Bobadilla, J, Ashoush, F, Samir Abdelaal, A, Qatora, M, Elsayed Hewalla, M, Metwalli, M, Atta, R, Abdelmajeed, A, Abosamak, N, Sabry, A, Shehata, S, Sallam, I, Amira, G, Sherief, M, Sherif, A, Salem, H, Hamdy, R, Aboulkassem, H, Ghaly, G, Sherif, G, Morsi, A, Abdelrahman, A, Omnia, A, Tawheed, A, El Kassas, M, Omar, W, Abdelsamed, A, Seleim, A, Azzam, A, Elfiky, M, Nabil, A, Ibraheem, M, Eldeeb, M, Fawzy, M, Hamed, H, Elfallal, A, Elfeki, H, Shalaby, M, Sakr, A, Alrahawy, M, Atif, H, Soltan, H, Sayed, A, Salah, A, Atiya, A, Wassim, K, Abbas, A, Abd Elazeem, H, Abd-Elkariem, A, Abd-Elkarem, M, Alaa, S, Ali, A, Ashraf, M, Ayman, A, Azizeldine, M, Elkhayat, H, Emad Mashhour, A, Gaber, M, Hamza, H, Hawal, I, Hetta, H, Elghazaly, S, Mohammed, M, Monib, F, Nageh, M, Saad, A, Saad, M, Shahine, M, Yousof, E, Youssef, A, Esmail, E, Khalaf, M, Eldaly, A, Ghoneim, A, Hawila, A, Badr, H, Elhalaby, I, Abdel-bari, M, Elbahnasawy, M, Hamada, M, Morsy, M, Hammad, M, Essa, M, Fayed, M, Elzoghby, M, Rady, M, Hamad, O, Salman, S, Sarsik, S, Abd-elsalam, S, Gamal Badr, S, El-Masry, Y, Moahmmed, M, Hailu, S, Wolde, A, Nida, S, Workneh, M, Y Ahmed, M, Fisseha, T, Kassa, D, Zeleke, H, Admasu, A, Laeke, T, Tirsit, A, Gessesse, M, Addissie, A, Bekele, D, Sarjanoja, E, Testelin, S, Dakpe, S, Devauchelle, B, Bettoni, J, Lavagen, N, Schmitt, F, Lemee, J, Boucher, S, Breheret, R, Kun-Darbois, J, Kahn, A, Gueutier, A, Bigot, P, Borraccino, B, Lakkis, Z, Doussot, A, Heyd, B, Manfredelli, S, Mathieu, P, Paquette, B, Turco, C, Barrabe, A, Louvrier, A, Moszkowicz, D, Giovinazzo, D, Bretagnol, F, Police, A, Charre, L, Volpin, E, Braham, H, El Arbi, N, Villefranque, V, Bendjemar, L, Girard, E, Abba, J, Trilling, B, Chebaro, A, Lecolle, K, Truant, S, El Amrani, M, Zerbib, P, Pruvot, F, Mathieu, D, Surmei, E, Mattei, L, Marin, H, Christou, N, Ballouhey, Q, Ferrero, P, Coste Mazeau, P, Tricard, J, Barrat, B, Taibi, A, Usseglio, J, 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Gjata, Arben, Boccalatte, Lui, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Townend, Philip, Aigner, Felix, Kronberger, Irmgard, Hossain, Kamral, VanRamshorst, Gabrielle, Lawani, Ismail, Ataide, Gustavo, Baiocchi, Glauco, Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Olivos, Maricarmen, Calvache, Jose, Perez Rivera, Carlos Jose, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Klat, Jaroslav, Novysedlak, René, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango, Eddy, Emile, Sameh H., Mengesha, Mengistu Gebreyohane, Hailu, Dr.Samuel, Tamiru, Hailu, Kauppila, Joona, Laukkarinen, Johanna, Arnaud, Alexi, Albertsmeiers, Marku, Lederhuber, Han, Loffler, Marku, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgio, Lorena, Maria Aguilera, Grecinos, Gustavo, Mersich, Tama, Wettstein, Daniel, Ghosh, Dhruv, Kembuan, Gabriele, Brouk, Peiman, Khosravi, Mohammad, Mozafari, Masoud, Adil, Ahmed, Mohan, Helen M., Zmora, Oded, Fiore, Marco, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Satoi, Sohei, Ayasra, Fari, Chaar, Mohammad, Fakhradiyev, Ildar R., Jamal, Mohammad, Elhadi, Muhammed, Gulla, Aiste, Roslani, April, Martinez, Laura, Ramos De La Medina, Antonio, Outani, Oumaima, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, van der Plas, Willemijn, Ademuyiwa, Adesoji, Osinaike, Babatunde, Seyi-olajide, Justina, Williams, Emmanuel, Pejkova, Sofija, Augestad, Knut Magne, Soreide, Kjetil, Al Balushi, Zainab, Qureshi, Ahmad, Sayyed, Raza, Mohsen Daraghmeh, Mustafa Abu, Abukhalaf, Sadi, Cukier, Moise, Gomez, Hugo, Shu, Sebastian, Vasquez, Ximena, Parreno-Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel, Santos, Irene, Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Litvin, Andrey, Ntirenganya, Faustin, AlAmeer, Ehab, Radenkovic, Dejan, Hong Xiang, Frederick Koh, Hoe, Chew Min, Chi Yong, James Ngu, Moore, Rachel, Nhlabathi, Ncamsile, Colino, Ruth Blanco, Bravo, Ana Minaya, Minaya-Bravo, Ana, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Elmujtaba, Mohammed, Jebril, William, Rutegård, Martin, Sund, Malin, Isik, Arda, Leventoğlu, Sezai, Abbott, Tom EF., Benson, Ruth, Caruna, Ed, Chakrabortee, Sohini, Demetriades, Andrea, Desai, Anant, Drake, Thomas D., Edwards, John G., Evans, Jonathan P., Ford, Samuel, Fotopoulou, Christina, Griffiths, Ewen, Hutchinson, Peter, Jenkinson, Michael D., Khan, Tabassum, Knight, Stephen, Kolias, Angelo, Leung, Elaine, McKay, Siobhan, Norman, Lisa, Ots, Riinu, Raghavan, Vidya, Roberts, Keith, Schache, Andrew, Shaw, Richard, Shaw, Katie, Smart, Neil, Stewart, Grant, Sundar, Sudha, Vimalchandran, Dale, Wright, Naomi, Alshryda, Sattar, Alser, Osaid, Breen, Kerry, Ganly, Ian, Kaafarani, Haytham, Kendall, Brittany, Mashbari, Hassan, Al Naggar, Hamza, Mazingi, Denni, Simoes, Joana F.F., Dajti, I., Valenzuela, J.I., Boccalatte, L.A., Gemelli, N.A., Smith, D.E., Dudi-Venkata, N.N., Kroon, H.M., Sammour, T., Roberts, M., Mitchell, D., Lah, K., Pearce, A., Morton, A., Dawson, A.C., Drane, A., Sharpin, C., Nataraja, R.M., Pacilli, M., Cox, D.R.A., Muralidharan, V., Riddiough, G.E., Clarke, E.M., Jamel, W., Qin, K.R., Pockney, P., Cope, D., Egoroff, N., Lott, N., Putnis, S., De Robles, S., Ang, Z., Mitteregger, M., Uranitsch, S., Stiegler, M., Seitinger, G., Aigner, F., Lumenta, D.B., Nischwitz, S.P., Richtig, E., Pau, M., Srekl-Filzmaier, P., Eibinger, N., Michelitsch, B., Fediuk, M., Papinutti, A., Seidel, G., Kahn, J., Cohnert, T.U., Messner, F., Öfner, D., Presl, J., Varga, M., Weitzendorfer, M., Emmanuel, K., Binder, A.D., Zimmermann, M., Holawe, S., Nkenke, E., Grimm, C., Kranawetter, M., Rahman Mitul, A., Islam, N., Karim, S., Komen, N., Ang, E., De Praetere, H., Tollens, T., Schols, G., Smets, C., Haenen, L., Quintens, J., Van Belle, K., Van Ramshorst, G.H., Pattyn, P., Desender, L., Martens, T., Van de putte, D., Lerut, P., Grimonprez, A., Janssen, M., De Smul, G., Wallaert, P., Van den Eynde, J., Oosterlinck, W., Van den Eynde, R., Sermon, A., Boeckxstaens, A., Cordonnier, A., De Coster, J., Jaekers, J., Politis, C., Miserez, M., Duchateau, N., De Gheldere, C., Flamey, N., Christiano, A., Guidi, B., Minussi, A.L., Castro, S., Okoba, W., Maldonado, F.H.R., Oliveira, P., Baldasso, T., Santos, L., Gomes, G.M.A., Buarque, I.L., Pol-Fachin, L., Bezerra, T.S., Barros, A.V., da Silva, A.M.R., Leite, A.L.S., Silvestre, D.W.A., Ferro, C.C., Araujo, M.S., Lopes, L.M., Damasceno, P.D., Araujo, D.H.S., Laporte, G., Salem, M.C., Guimaraes-Filho, M.A.C., Nacif, L., Flumignan, R.L.G., Nakano, L.C.U., Kuramoto, D.A.B., Aidar, A.L.S., Pereda, M.R., Correia, R.M., Santos, B.C., Carvalho, A.A., Amorim, J.E., Guedes Neto, H.J., Areias, L.L., Sousa, A.F., Flumignan, C.D.Q., Lustre, W.G., Moreno, D.H., Barros, N., Baptista-Silva, J.C.C., Matos, L.L., Kowaski, L.P., Kulcsar, M.A.V., Nunes, K.S., Teixeira, M.F., Nunes, R.L., Ijichi, T.R., Kim, N.J., Marreiro, A., Muller, B., Barakat Awada, J., Baiocchi, G., Kowalski, L.P., Vartanian, J.G., Makdissi, F.B., Aguiar, S., Marques, N., Carvalho, G.B., Marques, T.M.D.M., Abdallah, E.A., Zurstrassen, C.E., Gross, J.L., Zequi, S.C., Gonçalves, B.T., Santos, S.S., Duprat, J.P., Coimbra, F.J.F., Cicco, R., Takeda, F., Cecconello, I., Ribeiro, U., Gatti, A., Oliva, R., Nardi, C., Slavchev, M., Atanasov, B., Belev, N., Dell, A., Bigam, D., Dajani, K., Al Riyami, S., Martin, J., Cheng, D., Yang, H., Fayad, A., Carrier, F.M., Amzallag, E., Desroches, J., Ruel, M., Caminsky, N.G., Boutros, M., Moon, J., Wong, E.G., Vanounou, T., Pelletier, J., Wong, S., Girsowicz, E., Bayne, J., Obrand, D., Gill, H., Steinmetz, O., MacKenzie, K., Lukaszewski, M., Jamjoum, G., Richebé, P., Verdonck, O., Discepola, S., Godin, N., Idrissi, M., Briatico, D., Sharma, S., Talwar, G., Bailey, K., Lecluyse, V., Côté, G., Demyttenaere, S., Garfinkle, R., Kouyoumdjian, A., Dumitra, S., Khwaja, K., Luo, L., Berry, G., Liberman, A.S., Schmid, S., Spicer, J., Al Farsi, M., Abou-Khalil, J., Couture, E., Mohammadi, S., Tremblay, H., Gagné, N., Bergeron, A., Turgeon, Af, Costerousse, O., Bellemare, D., Babin, C., Blier, C., Wood, M.L., Persad, A., Groot, G., Pham, H., D'Aragon, F., Carbonneau, E., Bouchard, M., Masse, M., Pesant, F., Héroux, J., Karanicolas, P., Hallet, J., Nadler, A., Nathens, A., Ko, M., Brar, A., Mayson, K., Kidane, B., Srinathan, S., Escudero, M.I., Reyes, J.T., Modolo, M.M., Ramirez Nieto, P., Sepulveda, R., Bolbarán, A., Molero, A., Ruiz, I., Reyes, G.P., Salas, R., Suazo, C., Muñoz, R., Grasset, E., Inzunza, M., Besser, N., Irarrázaval, M.J., Jarry, C., Bellolio, F., Romero Manqui, C.A., Ruiz Esquide, M., Fuentes, T., Campos, J., Perez Rivera, C.J., Cabrera, P.A., Pinilla, R.E., Guevara, O., Jimenez Ramirez, L.J., Velasquez Cuasquen, B.G., Herrera Mora, D.R., Bonilla, A., Diaz, S., Manrique, E., Facundo, H., Velez Bernal, J.L., Ángel, J., García, M., Guzmán, L., Lehmann, C., Cervera, S., Trujillo Sanchez, L.M., Guevara, R., Valbuena, D., Suarez, L., Jimenez, G., Velandia, A., Vargas, J., Espinosa, J., Rey, S., Mendoza Quevedo, Jairo, Calvache, J.A., Orozco-Chamorro, C.M., Sánchez-Gómez, T.A., Rojas-Tejada, D.A., Mihanovic, J., Bakmaz, B., Rakvin, I., Sulen, N., Andabaka, T., Luksic, I., Mamic, M., Martinek, L., Skrovina, M., Žatecký, J., Peteja, M., Kristensen, H.Ø., Mekhael, M., Christensen, P., Westh, L., Smith, H., Haugstvedt, A.F., Jönsson, M.L., Crespo, A., Batista, S., Rodriguez-Abreu, J., Tactuk, N., Diaz-Delgado, P.J., Rivas, R., Sarmiento-Bobadilla, J.A., Ashoush, F., Samir Abdelaal, A., Qatora, M.S., Elsayed Hewalla, M.E., Metwalli, M., Atta, R., Abdelmajeed, A., Abosamak, N.E., Sabry, A., Shehata, S., Sallam, I., Amira, G., Sherief, M., Sherif, A., Salem, H., Hamdy, R., Aboulkassem, H., Ghaly, G., Sherif, G., Morsi, A., Abdelrahman, A., Omnia, Ahmed, Tawheed, A., El Kassas, M., Omar, W., Abdelsamed, A., Seleim, A., Azzam, A.Y., ElFiky, M., Nabil, A., Ibraheem, M., ELDeeb, M., Fawzy, M., Hamed, H., Emile, S., Elfallal, A., Elfeki, H., Shalaby, M., Sakr, A., Alrahawy, M., Atif, H., Soltan, H., Sayed, A.K., Salah, A., Atiya, A., Wassim, K., Abbas, A.M., Abd Elazeem, H.A.S., Abd-Elkariem, A.Y., Abd-Elkarem, M.M., Alaa, S., Ali, A.K., Ashraf, M., Ayman, A., Azizeldine, M.G., Elkhayat, H., Emad Mashhour, A., Gaber, M., Hamza, H.M., Hawal, I., Hetta, H.F., Elghazaly, S.M., Mohammed, M.M., Monib, F.A., Nageh, M.A., Saad, A., Saad, M.M., Shahine, M., Yousof, E.A., Youssef, A., Esmail, E., Khalaf, M., Eldaly, A., Ghoneim, A., Hawila, A., Badr, H., Elhalaby, I., Abdel-bari, M., Elbahnasawy, M., Hamada, M.K., Morsy, M.S., Hammad, M., Essa, M., Fayed, M.T., Elzoghby, M., Rady, M., Hamad, O., Salman, S., Sarsik, S., Abd-elsalam, S., Gamal Badr, S., El-Masry, Y., Moahmmed, M.M.H., Hailu, S., Wolde, A., Mengesha, M., Nida, S., Workneh, M., Y Ahmed, M., Fisseha, T., Kassa, D., Zeleke, H., Admasu, A., Laeke, T., Tirsit, A., Gessesse, M., Addissie, A., Bekele, D., Kauppila, J.H., 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Kantor, E., Gossot, D., Seguin-Givelet, A., Fuks, D., Grigoroiu, M., Sanchez Salas, R., Cathelineau, X., Macek, P., Barbé, Y., Rozet, F., Barret, E., Mombet, A., Cathala, N., Brian, E., Zadegan, F., Conso, C., Blanc, T., Broch, A., Sarnacki, S., Ali, L., Bonnard, A., Peycelon, M., Hervieux, E., Clermidi, P., Maisonneuve, E., Aubry, E., Thomin, A., Langlais, T., Passot, G., Glehen, O., Cotte, E., Lifante, J.C., De Simone, B., Chouillard, E., Arnaud, A.P., Violas, P., Bergeat, D., Merdrignac, A., Scalabre, A., Perotto, L.O., Le Roy, B., Haddad, E., Vermersch, S., Ezanno, A.C., Barbier, O., Vigouroux, F., Malgras, B., Aime, A., Seeliger, B., Mutter, D., Philouze, G., Pessaux, P., Germain, A., Chanty, H., Ayav, A., Kassir, R., Von theobald, P., Sauvat, F., O'Connor, J., Mayombo Idiata, M., O'Connor, Z., Tchoba, S., Modabber, A., Winnand, P., Hölzle, F., Sommer, B., Shiban, E., Wolf, S., Anthuber, M., Sommer, F., Kaemmerer, D., Schreiber, T., Kamphues, C., Lauscher, J.C., Schineis, C., 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F., Pasini, F., Ugolini, G., Fabbri, N., Feo, C.V., Righini, E., Gennari, S., Chiozza, M., Anania, G., Urbani, A., Koleva Radica, M., Carcoforo, P., Portinari, M., Sibilla, M., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M.N., Risaliti, M., Sorbi, F., Taddei, A., Lizzi, V., Vovola, F., Arminio, A., Cotoia, A., Sarni, A.L., Familiari, P., D'Andrea, G., Picotti, V., Bàmbina, F., Fontana, T., Barra, F., Ferrero, S., Gustavino, C., Kratochwila, C., Ferraiolo, A., Costantini, S., Batistotti, P., Aprile, A., Almondo, C., Ball, L., Robba, C., Scabini, S., Pertile, D., Massobrio, A., Soriero, D., D'Ugo, S., Depalma, N., Spampinato, M.G., Lippa, L., 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Cenciarelli, S., Adamoli, L., Ansarin, M., Fumagalli Romario, U., Mastrilli, F., Mariani, N.M., Nicastro, V., Cellerino, P., Colombo, F., Frontali, A., Bondurri, A., Guerci, C., Maffioli, A., Ferrario, L., Candiani, M., Bonavina, G., Ottolina, J., Valsecchi, L., Mortini, P., Gagliardi, F., Piloni, M., Medone, M., Negri, G., Bandiera, A., De Nardi, P., Sileri, P., Carlucci, M., Pelaggi, D., Rosati, R., Vignali, A., Parise, P., Elmore, U., Tamini, N., Nespoli, L.C., Rennis, M., Pitoni, L., Chiappetta, M.F., Vico, E., Fruscio, R., Grassi, T., Sasia, D., Migliore, M., Gattolin, A., Rimonda, R., Travaglio, E., Olearo, E., Tufo, A., Marra, E., Maida, P., Marte, G., Tammaro, P., Incollingo, P., Izzo, F., Belli, A., Patrone, R., Albino, V., Leongito, M., Granata, V., Piccirillo, M., Palaia, R., Francone, E., Gentilli, S., Nikaj, H., Fiorini, A., Norcini, C., Chessa, A., Marino, M.V., Mirabella, A., Vaccarella, G., Musini, L., Ampollini, L., Bergonzani, M., Varazzani, A., Bellanti, L., Domenichini, M., Cabrini, E., Fornasari, A., Freyrie, A., Dejana, D.O., D'Angelo, G., Bertoli, G., Di Lella, F., Bocchialini, G., Falcioni, M., Lanfranco, D., Poli, T., Giuffrida, M., Annicchiarico, A., Perrone, G., Catena, F., Raffaele, A., De Manzoni Garberini, A., Baldini, E., Conti, L., Ribolla, M., Capelli, P., Isolani, S.M., Maniscalco, P., Cauteruccio, M., Ciatti, C., Puma Pagliarello, C., Gattoni, S., Galleano, R., Malerba, M., Ciciliot, M., Farnesi, F., Calabrò, M., Pipitone Federico, N.S., Lunghi, E.G., Muratore, A., Di Franco, G., Palmeri, M., Tartaglia, D., Coccolini, F., Chiarugi, M., Simoncini, T., Gadducci, A., Caretto, M., Giannini, A., Perutelli, A., Domenici, L., Garibaldi, S., Capanna, R., Andreani, L., Furbetta, N., Guadagni, S., Bianchini, M., Gianardi, D., Pinotti, E., Montuori, M., Carissimi, F., Baronio, G., Zizzo, M., Castro Ruiz, C., Annessi, V., Montella, M.T., Falco, G., Mele, S., Ferrari, G., Mastrofilippo, V., Mandato, V.D., Aguzzoli, L., Corbellini, C., Baldi, C., Sampietro, G.M., Palini, G.M., Zanini, N., Garulli, G., Barone, R., Murgese, A., Mungo, S., Grasso, M., Marafante, C., Birolo, S.L., Moggia, E., Caccetta, M., Masciandaro, A., Deirino, A., Garino, M., Perinotti, R., Maiello, F., Gordini, L., Lombardi, C.P., Marzi, F., Marra, A.A., Ratto, C., Di Muro, M., Litta, F., De Simone, V., Cozza, V., Rosa, F., Agnes, A., Parello, A., Alfieri, S., Sganga, G., Lapolla, P., Mingoli, A., De Toma, G., Fiori, E., La Torre, F., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G.B., Cicerchia, P.M., Bruzzaniti, P., Santoro, A., Frati, A., Marruzzo, G., Ribuffo, D., Sagnotta, A., Marino Cosentino, L., Mancini, S., Lisi, G., Spoletini, D., Bellato, V., Campanelli, M., Sica, G., Siragusa, L., Bonavina, L., Asti, E., Bernardi, D., Lovece, A., Perra, T., Porcu, A., Fancellu, A., Feo, C.F., Scanu, A.M., Tuminello, F., Franceschi, A., Langone, A., Fleres, F., Spolini, A., Bordoni, P., Franzini, M., Clarizia, G., Grechi, A., Longhini, A., Guaitoli, E., Manca, G., Grossi, U., Novello, S., Zanus, G., Romano, M., Rossi, S., Ferrara, F., La Torre, M., Pirozzolo, G., Recordare, A., Paiella, S., Turri, G., Rattizzato, S., Campagnaro, T., Guglielmi, A., Pedrazzani, C., Ruzzenente, A., Poletto, E., Conci, S., Casetti, L., Fontana, M., Salvia, R., Malleo, G., Esposito, A., Landoni, L., De Pastena, M., Bassi, C., Tuveri, M., Nobile, S., Marchegiani, G., Bortolasi, L., Sambugaro, E., Malavolta, M., Moretto, G., Impellizzeri, H., Inama, M., Barugola, G., Ascari, F., Ruffo, G., Granieri, S., Cotsoglou, C., Berselli, M., Desio, M., Marchionini, V., Cocozza, E., Di Saverio, S., Ietto, G., Iovino, D., Carcano, G., Ayasra, F., Qasem, A., Ayasra, Y., Al-Masri, M., Abou Chaar, M.K., Al-Najjar, H., Ghandour, K., Alawneh, F., Abdel Jalil, R., Abdel Al, S., Elayyan, M., Ghanem, R., Lataifeh, I., Alsaraireh, O., Abu Za’nouneh, F.J., Fahmawee, T., Ibrahim, A., Obeidat, K., Lee, K.J., Shin, S.J., Chung, H., Albader, I., Alabbad, J., Albader, M.A.S., Bouhuwaish, A., Taher, A.S., Omar, M.S.M., Abdulwahed, E., Biala, M., Morgom, M., Elhadi, A., Alarabi, A., Msherghi, A., Elhajdawe, F., Alsoufi, A., Salamah, A., Salama, H., Bulugma, M., Almabrouk, H., Venskutonis, D., Dainius, E., Kubiliute, E., Bradulskis, S., Parseliunas, A., Kutkevicius, J., Subocius, A., Cheong, Y.J., Masood, M.S., Ngo, C.W., Saravanan, R., Abdul Maei, N., Hayati, F., Amin Sahid, N., Yanowsky Reyes, G., Orozco Perez, J., Damian, R., Santana Ortiz, R., Colunga Tinajero, C.A., Cordera, F., Gómez-Pedraza, A., Maffuz-Aziz, A., Posada, J.A., De la Rosa Abaroa, M.A., Alvarez, M.R., Arrangoiz, R., Hernández, R., Bozada Gutierrez, K., Trejo-Avila, M., Valenzuela-Salazar, C., Herrera-Esquivel, J., Moreno-Portillo, M., Pinto-Angulo, V.M., Sosa-Duran, E.E., Ziad-Aboharp, H., Jimenez Villanueva, X., Soulé Martínez, C.E., Lupián-Angulo, A.I., Martínez Zarate J, Jacobo, Reyes Rodriguez, E., Montalvo Dominguez, G., Becerra García, F.C., Melchor-Ruan, J., Vilar-Compte, D., Romero-Bañuelos, E., Herrera-Gomez, A., Meneses-Garcia, A., Isla-Ortiz, D., Salcedo-Hernández, R.A., Hernández-Nava, J.M., Morales-Castelan, J.E., Posadas-Trujillo, O.E., Buerba, G.A., Alfaro-Goldaracena, A., Pena Gomez-Portugal, E., Lopez-Pena, G., Hinojosa, C.A., Mercado, M.A., Ramos-De la Medina, A., Martinez, L., Duran, I., Gonzalez, D.S., Martinez, M.J., Nayen Sainz de la Fuente, A., Miguelena, L., Hernández Miguelena, L., Louraoui, S.M., El Azhari, A., Rghioui, M., Khya, E., Ghannam, A., Souadka, A., El Ahmadi, B., Belkhadir, Z.H., Majbar, M.A., Benkabbou, A., Mohsine, R., Oudrhiri, M.Y., Bechri, H., Arkha, Y., El Ouahabi, A., Frima, H., Bachiri, S., Groen, L.C., Verhagen, T., ter Brugge, F.M., Scheijmans, J.C.G., Boermeester, M.A., Hompes, R., Meima-van Praag, E.M., Sharabiany, S., Borgstein, A.B.J., Gisbertz, S.S., van Berge Henegouwen, M.I., Gans, S., Van Duijvendijk, P., Herklots, T., De Hoop, T., De Graaff, M.R., Sloothaak, 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Sudarsanam, A., Rolls, A., Lyons, O., Onida, S., Shalhoub, J., Sugand, K., Park, C., Sarraf, K.M., Erridge, S., Kinross, J., Denning, M., Yalamanchili, S., Abuown, A., Ibrahim, M., Martin, G., Davenport, D., Wheatstone, S., Kasivisvanathan, V., Kapriniotis, K., Elhamshary, A., Imam, S.M.B., Kalavrezos, N., Sinha, D., Chand, M., Green, L., Beech, N., McEwen, R., Kiconco, H., Andreani, S.M., Bath, M.F., Sahni, A., Judkins, N., Rigueros Springford, L., Bacarese-Hamilton, J., Taylor, F.G., Parmar, C., Mccluney, S., Shah, S., Talwar, R., Patel, K., Askari, A., Jambulingam, P.S., Shaw, S., Maity, A., Hatzantonis, C., Sagar, J., Kudchadkar, S., Cirocchi, N., Chan, C.H., Reynolds, J., Alexander, M.E., Smart, C.J., Jayasankar, B., Balasubramaniam, D., Abdelsaid, K., Mundkur, N., Gallagher, B., Shah, J., Anthoney, J., Emmerson, O., Stylianides, N., Abdalla, M., Newton, K., Bhatia, K., Edmondson, R., Abdeh, L., Jones, D., Zeiton, M., Ismail, O., Naseem, H., Advani, R., Duff, S., Moura, F., Brown, B.C., Khan, A., Asaad, P., Wadham, B., Aneke, I.A., Collis, J., Warburton, H., Fell, A., Smith, A., Halkias, C., Nikolaou, S., English, C., Kristinsson, S., Oni, T., Ilahi, N., Ballantyne, K., Woodward, Z., Merh, R., Dunning, J., Viswanath, Y., Freystaetter, K., Dixon, J., Hadfield, J.N., Hilley, A., Egglestone, A., Smith, B., Hine, T., Keeler, B., Soulsby, R.E., Taylor, A., Davies, E., Ryska, O., Raymond, T., Rogers, S., Tong, A., Hawkin, P., Tingle, S., Abbadessa, F., Sachdeva, A., Rai, B., Chan, C.D., McPherson, I., Booth, K., Mahmoud Ali, F., Pandanaboyana, S., Grainger, T., Nandhra, S., Patience, A., Roy, C., Williams, T., Dawe, N., McCaffer, C., Riches, J., Bhattacharya, S., Moir, J., Kalson, N.S., Elamin Ahmed, H., Mellor, C., Saleh, C., Koshy, R.M., Hammond, J., Sanderson, L., Wahed, S., Phillips, A.W., Ghosh, K., Tang, A., Beamish, A.J., Price, C., Bosanquet, D., Magowan, D., Solari, F., Williams, G., Nassa, H., Smith, L., Robertson-Smith, B., Mahmoud, A., Ameerally, P., Finch, J.G., Gnanachandran, C., Pop, I., Rogers, M., Yousef, Y., Mohamed, I., Woods, R., Zahid, H., Mundy, G., Sreedharan, L., Baskaran, D., Shaikh, I., Seebah, K., Reid, J., Watts, D., Kouritas, V., Chrastek, D., Maryan, G., Gill, D.F., Khatun, F., Gajjar, K., Williamson, K., Bratt, D., Konstantinidi, K., Walton, T., Burnside, N., Weaver, H., Hawari, M., Addae-Boateng, E., Rollett, R.A., Collins, M.L., Tamimy, M.S., Riyat, H., Wen, J., Neil-Dwyer, J., Brewer, H., Humes, D., Worku, D., Chowdhury, A., Oyende, O., Lewis-Lloyd, C., Adiamah, A., Koh, A., Jackman, J., Vohra, R., Navarro, A., Reilly, J., Aujayeb, A., Townshend, D., McLarty, N., Shenfine, A., Jackson, K., Johnson, C., Dass, D., Ford, D., Winter, S.C., Belcher, E., Stavroulias, D., Di Chiara, F., Wallwork, K., Qureishi, A., Lami, M., Sravanam, S., Mastoridis, S., Shah, K., Chidambaram, S., Smillie, R., Shaw, A.V., Bandyopadhyay, S., Cernei, C., Bretherton, C., Jeyaretna, D., Ganau, M., Piper, R.J., Duck, E., Brown, S., Jelley, C., Tucker, S.C., Bond-Smith, G., Griffin, X.L., Tebala, G.D., Neal, N., Vatish, M., Noton, T.M., Ghattaura, H., Maher, M., Fu, H., Risk, O.B.F., Soleymani majd, H., Sinha, S., Shankar, S., Aggarwal, A., Kharkar, H., Lakhoo, K., Verberne, C., Dean, B., Luney, C., Myatt, R., Williams, M.A., McVeigh, J., Rogers, L.J., Labib, P.L., Miller, D., Minto, G., Hope, N., Marchbank, A., Emslie, K., Panahi, P., Ho, B., Perkins, C., Clough, E., Roy, H., Enemosah, I., Campbell, R., Natale, J., Gohil, K., Rela, M., Raza, N., Biliatis, I., Khan, J., Thiruchandran, G., Toh, S.K.C., Ahmad, Y., Allana, A., Bellis, C., Babawale, O., Phan, Y.C., Lokman, U., Ismail, M., Koc, T., Witek, A., Duggleby, L., Shamoon, S., Stefan, S., Clancy, H., Chadha, R., Middleton, S.B., Wilmott, K., Hayden, C., Mclaren, C., Sutton, J., Whyte, A., Belgaumkar, A., Day, A., Gilbert, C., Oyewole, B., Narayan, P., Dent, H., Sandhya, A., De Silva, T., Waheed, S., Kapoor, K., Belgaumkar, A.P., Fahim, M., Gala, T., Mithany, R., Morgan, R., Abdelkarim, M., Maw, A., Asqalan, A., Sundaram Venkatesan, G., Singh, S., Mukherjee, S., Ferguson, D., Mansuri, A., Thakrar, A., Wickramarachchi, L., Cuthbert, R., Sivayoganathan, S., Chui, K., Karam, E., Dott, C., Madhvani, K., Hampton, M., Hormis, A.P., Fountain, D.M., Laurente, R., Sigamoney, K.V., Dasa, M., George, K., Naqui, Z., Galhoum, M., Lipede, C., Gabr, A., Radhakrishnan, A., Hasan, M.T., Kalenderov, R., Pathmanaban, O., Chelva, R., Branagan, G., Longstaff, L., Ding, D., Barlow, C., Foster, J., Edwards, J., Ward, A., Tadross, D., Majkowski, L., Blundell, C., Forlani, S., Nair, R., Guha, S., Brown, S.R., Steele, C., Kelty, C.J., Newman, T., Lee, M., Chetty, G., Lye, G., Balasubramanian, S.P., Sureshkumar Shah, N., Sherif, M., Al-mukhtar, A., Whitehall, E., Giblin, A., Sharkey, A., Adamec, A., Madan, S., Narice, B., Sterrenburg, M., Thompson, A., Varley, I., Stavrakas, M., Rominiyi, O., Ray, J., Crank, M., Bacon, A., Al-Tamimi, Y., Catto, J., Saad, S., Abd Kahar, N.N., Sou, A., Simpson, D., Hamilton, E., Blair, J., Jallad, S., Lord, J., Anderson, C., El Kafsi, J., Logishetty, K., Saadya, A., Midha, R., Ip, M., Subbiah Ponniah, H., Stockdale, T., Bacarese-Hamilton, T., Foster, L., James, A., Anjarwalla, N., Marujo Henriques, D., Hettige, R., Baban, C., Tenovici, A., Salerno, G., Lane, J., Colvin, H.V., Badran, A., Cadersa, A., Cumpstey, A., Hamady, Z., Aftab, R., Wensley, F., Byrne, J., Morrison-Jones, V., Sekhon, G.K., Shields, H., Shakoor, Z., Yener, A., Talbot, T., Alzetani, A., Cresner, R., Babu, B.H.B., Liyanage, A.S.D., Newman, S., Blake, I., Weerasinghe, C., Baumber, R., Parry, J., Menakaya, C., Webb, J.I., Antar, M., Modi, N., Sofat, R., Noel, J., Nunn, R., Adegbola, S., Eriberto, F., Sharma, V., Tanna, R., Lodhia, S., Johnson, D., Hughes, I., Hall, J., Rooney, J., Chatterji, S., Zhang, Y., Owen, R., Rudic, M., Hunt, J., Zakai, D., Aladeojebi, A., Ali, M., Gaunt, A., Barmayehvar, B., Kitchen, M., Gowda, M., Mansour, F., Jarvis, M., Halliday, E., Lefroy, R., Nanjaiah, P., Lin, D.J., Rajgor, A.D., Scurrah, R.J., Kang, C., Watson, L.J., Harris, G., Royle, T., Cunningham, Y., Steel, B., Luk, A.C.O., Boulton, A.J., Khan, T., Bakolas, G., Herrod, P., Gemmill, E., Boyd-Carson, H., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Li, Z., Parkins, K., Spencer, N., Harries, R., Egan, R.J., Motter, D., Jenvey, C., Mahoney, R., Fine, N., Minto, T., Henry, A., Hollyman, M., Grieco, C., Gemmell, C., Whitmore, H., Babar, M.S., Goodrum, S., Scott, R., Collard, B., Lau, K., Thomas, E., Patel, A., Allison, J., Bowen, J., Dias, A., Mahendran, B., Gopalswamy, S., Patil, S., Scott, L., Sarveswaran, J., Michel, M., Ravindran, S., Subba, K., Abou-Foul, A.K., Khalefa, M., Hossain, F., Moores, T., Pickering, L., Stables, G., Doorgakant, A., Thiruvasagam, V.G., Carter, J., Reid, S., Mohammed, R., Marlow, W., Ferguson, H., Wilkin, R., Konstantinou, C., Yershov, D., Vatish, J., Denning, A., Shah, H.B., Cross, G.W.V., Seyed-Safi, P., Smart, Y.W., Kuc, A., Al-Yaseen, M., Olivier, J., Hanna, M., Eskander, P., Duncan, R., Halaseh, S., Das, R., Wynn Jones, H., Divecha, H., Whelton, C., Board, T., Powell, S., Magee, C., Agarwal, K., Mangos, E., Nambirajan, T., Vidya, R., Chauhan, G., Kaur, J., Burahee, A., Bleibleh, S., Pigadas, N., Snee, D., Bhasin, S., Crichton, A., Habeebullah, A., Bodla, A.S., Yassin, N., Mondragon, M., Dewan, V., Flindall, I., Mahendran, V., Hanson, A., Jenner, E., Richards, J., Thomas-Fernandez, K., Wall, R., Alqallaf, A., Ben-Sassi, A., Mellor, K., Joshi, P., Joshi, Y., Young, R., Miu, V., Sheridan, K., MacDonald, L., Green, S., Onos, L., Wong, J.J., Napolitano, L., Hemmila, M., Amin, D., Abramowicz, S., Roser, S.M., Olson, K.A., Riley, C., Heron, C., Cardenas, T., Leede, E., Thornhill, M., Haynes, A.B., McElhinney, K., Roward, S., Trust, M.D., Hill, C.E., Teixeira, P.G., Etchill, E., Stevens, K., Ladd, M.R., Long, C., Rose, J., Kent, A., Yesantharao, P., Vervoort, D., Jenny, H., Gabre-Kidan, A., Margalit, A., Tsai, L., Malapati, H., Yesantharao, L., Abdou, H., Diaz, J., Richmond, M., Clark, J., O'Meara, L., Hanna, N., Ying, Y., Fleming, J., Ovaitt, A., Gigliotti, J., Fuson, A., Cooper, Z., Salim, A., Hirji, S.A., Chung, C., Hansen, L., Okafor, B.U., Roxo, V., Raut, C.P., Jolissaint, J.S., Mahvi, D.A., Kaafarani, H., Breen, K., Bankhead-Kendall, B., Alser, O., Mashbari, H., Velmahos, G., Maurer, L.R., El Moheb, M., Gaitanidis, A., Naar, L., Christensen, M.A., Kapoen, C., Langeveld, K., El Hechi, M., Mokhtari, A., Haqqani, M.H., Drake, F.T., Goldenberg-Sandau, A., Galbreath, B., Reinke, C., Ross, S., Thompson, K., Manning, D., Perkins, R., Eriksson, E., Evans, H., Masrur, M., Giulianotti, P., Benedetti, E., Chang, G., Ourieff, J., Dehart, D., Dorafshar, A., Price, T., Bhama, A.R., Torquati, A., Cherullo, E., Kennedy, R., Myers, J., Rubin, K., Ban, V.S., Aoun, S.G., Batjer, H.H., Caruso, J., Carmichael, H., Velopulos, C.G., Wright, F.L., Urban, S., McIntyre, R.C., Schroeppel, T.J., Hennessy, E.A., Dunn, J., Zier, L., Burlew, C., Coleman, J., Colling, K.P., Hall, B., Rice, H.E., Hwang, E.S., Olson, S.A., Moris, D., Verma, R., Hassan, R., Volpe, A., Merola, S., O'Banion, L.A., Lilienstein, J., Dirks, R., Marwan, H., Almasri, M., Kulkarni, G., Mehdi, M., Abouassi, A., Abdallah, M., San Andrés, M., Eid, J., Aigbivbalu, E., Sundaresan, J., George, B., Ssentongo, A., Ssentongo, P., Oh, J.S., Hazelton, J., Maines, J., Gusani, N., Garner, M., Horvath, S., Zheng, F., Ujiki, M., Kinnaman, G., Meagher, A., Sharma, I., Holler, E., McKenzie, K., Chan, J., Fretwell, K., Nugent, W., Khalil, A., Chen, D., Post, N., Rostkowski, T., Brahmbhatt, D., Huynh, K., Hibbard, M.L., Schellenberg, M., Martin, R.C.G., Bhutiani, N., Giorgakis, E., Laryea, J., Bhavaraju, A., Sexton, K., Kost, M., Kimbrough, M., Burdine, L., Kalkwarf, K., Robertson, R., Gosain, A., Camp, L., Lewit, R., Kronenfeld, J.P., Urrechaga, E., Goel, N., Rattan, R., Hart, V., Gilna, G., Cioci, A., Ruiz, G., Rakoczy, K., Pavlis, W., Saberi, R., Morris, R., Karam, B.S., Brathwaite, C.E.M., Liu, H., Petrone, P., Hakmi, H., Sohail, A.H., Baltazar, G., Heckburn, R., Nygaard, R.M., Colonna, E.T., Endorf, F.W., Hill, M.J., Maiga, A., Dennis, B., Levin, J.H., Lallemand, M., Choron, R., Peck, G., Soliman, F., Rehman, S., Glass, N., Juthani, B., Deisher, D., Ruzgar, N.M., Ullrich, S.J., Sion, M., Paranjape, C., Kar, A.R., Gillezeau, C., Rapp, J., Taioli, E., Miles, B.A., Alpert, N., Podolsky, D., Coleman, N.L., Callahan, M.P., Ganly, I., Brown, L., Monson, J.R.T., Dehal, A., Abbas, A., Soliman, A., Kim, B., Jones C Dauer, M.D.E., Renza-Stingone, E., Hernandez, E., Gokcen, E., Kropf, E., Sufrin, H., Hirsch, H., Ross, H., Engel, J., Sewards, J., Poggio, J., Sanserino, K., Rae, L., Philp, M., Metro, M., McNelis, P., Petrov, R., Pazionis, T., Till, B., Lamm, R., Rios-Diaz, A.J., Palazzo, F., Rosengart, M., Nicholson, K., Carrick, M.M., Rodkey, K., Suri, A., Callcut, R., Nicholson, S., Talathoti, N., Klaristenfeld, D., Biffl, W., Marsh, C., Schaffer, K., Berndtson, A.E., Averbach, S., Curry, T., Kwan-Feinberg, R., Consorti, E., Gonzalez, R., Grolman, R., Liu, T., Merzlikin, O., Abel, M.K., Ozgediz, D., Boeck, M., Kornblith, L.Z., Nunez-Garcia, B., Robinson, B., Park, P., Utria, A.F., Rice-Townsend, S.E., Javid, P., Hauptman, J., Kieran, K., Nehra, D., Walters, A., Cuschieri, J., Davidson, G.H., Nunez, J., Cosker, R., Eckhouse, S., Choudhry, A., Marx, W., Jamil, T., Seegert, S., Al-Embideen, S., Quintana, M., Jackson, H., Wexner, S.D., Kent, I., Martins, P.N., Alshehari, M., Al-Naggar, H., Alsayadi, M., Alyazidi, M., Shream, S., Alhaddad, W., Maqus, A., Abu Hamra'a, M., Alsayadi, R., Ghannam, R., Al-Maqtari, S., Masdoos, S., Al-Harazi, Y., Bajjah, H., Al-ameri, S., Aldawbali, M., Gwini, G.P., and Mazingi, D.
Subjects: Pulmonary and Respiratory Medicine, Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), complication, Article, NO, Cohort Studies, outcomes, complications, following cardiac surgery, coronavirus disease 2019, Postoperative Complications, Cardiovascular Diseases, Female, Humans, Middle Aged, SARS-CoV-2, COVID-19, Cardiac Surgical Procedures, Internal medicine, Cardiovascular Disease, medicine, Cardiac Surgical Procedure, In patient, LS7_4, business.industry, Cardiac surgery, outcome, Surgery, Cohort Studie, Cardiology and Cardiovascular Medicine, business, cardiac surgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study, Human
Abstract: The outbreak of severe acute respiratory syndromecoronavirus-2, the cause of coronavirus disease 2019 (COVID-19) in December 2019 represented a global emergency accounting for more than 2.5 million deaths worldwide.1 It has had an unprecedented influence on cardiac surgery internationally, resulting in cautious delivery of surgery and restructuring of services.2 Understanding the influence of COVID-19 on patients after cardiac surgery is based on assumptions from other surgical specialties and single-center studies. The COVIDSurg Collaborative conducted a multicenter cohort study, including 1128 patients, across 235 hospitals, from 24 countries demonstrating perioperative COVID-19 infection was associated with an overall mortality of 24% and postoperative pulmonary complications in half of all patients.3 Cardiac surgery arguably represents a higher risk population than general or orthopedic surgery due to the high American Society of Anesthesiologists grades and multiple comorbidities usually seen. We present a subgroup analysis of COVIDSurg data, including patients who underwent cardiac surgery between March 1, 2020, and July 31, 2020, across 13 countries, with a confirmed perioperative (7 days preoperative up to 30 days postoperative) diagnosis of COVID-19 infection. This is presented in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology statement for cohort studies.4 Categorical variables were expressed as frequency and percentages and c2 or Fisher exact test was used to compare categorical variables. Only anonymized data were collected. Patient consent was obtained unless it was waived by local research committees. In the United Kingdom, the study was registered at each site as either a clinical audit or service evaluation and consent was waived. In other countries, local investigators were responsible for contacting research ethics committees to obtain local or national approvals in line with applicable regulations.
Published: 2021
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12. Fabric surface characterization: assessment of deep learning-based texture representations using a challenging dataset

Author: Yuting Hu, Motaz Alfarraj, Anirudha Sundaresan, Sundaresan Jayaraman, Zhiling Long, Sungmee Park, and Ghassan AlRegib
Subjects: FOS: Computer and information sciences, Surface (mathematics), 010407 polymers, Polymers and Plastics, business.industry, Computer science, Computer Vision and Pattern Recognition (cs.CV), Materials Science (miscellaneous), Deep learning, Image and Video Processing (eess.IV), ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing, Texture (music), 01 natural sciences, Industrial and Manufacturing Engineering, 0104 chemical sciences, Characterization (materials science), FOS: Electrical engineering, electronic engineering, information engineering, Hardware_INTEGRATEDCIRCUITS, Computer vision, Artificial intelligence, General Agricultural and Biological Sciences, business
Abstract: Tactile sensing or fabric hand plays a critical role in an individual's decision to buy a certain fabric from the range of available fabrics for a desired application. Therefore, textile and clothing manufacturers have long been in search of an objective method for assessing fabric hand, which can then be used to engineer fabrics with a desired hand. Recognizing textures and materials in real-world images has played an important role in object recognition and scene understanding. In this paper, we explore how to computationally characterize apparent or latent properties (e.g., surface smoothness) of materials, i.e., computational material surface characterization, which moves a step further beyond material recognition. We formulate the problem as a very fine-grained texture classification problem, and study how deep learning-based texture representation techniques can help tackle the task. We introduce a new, large-scale challenging microscopic material surface dataset (CoMMonS), geared towards an automated fabric quality assessment mechanism in an intelligent manufacturing system. We then conduct a comprehensive evaluation of state-of-the-art deep learning-based methods for texture classification using CoMMonS. Additionally, we propose a multi-level texture encoding and representation network (MuLTER), which simultaneously leverages low- and high-level features to maintain both texture details and spatial information in the texture representation. Our results show that, in comparison with the state-of-the-art deep texture descriptors, MuLTER yields higher accuracy not only on our CoMMonS dataset for material characterization, but also on established datasets such as MINC-2500 and GTOS-mobile for material recognition., arXiv admin note: text overlap with arXiv:1905.09907
Published: 2020
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13. Temporal dynamics of nitric oxide wave in early vasculogenesis

Author: Suvro Chatterjee, Jyotirmaya Behera, Geege Venkatachalam, Lakshmikirupa Sundaresan, Krithika Rajendran, and Saranya Rajendran
Subjects: Nitric Oxide Synthase Type III, Angiogenesis, Nitric Oxide Synthase Type II, Chick Embryo, Nitric Oxide, Endothelial NOS, Nitric oxide, chemistry.chemical_compound, Vasculogenesis, Animals, Medicine, Nitrite, Nitrites, Tube formation, biology, business.industry, NF-kappa B, Nitrite reductase, Cell biology, Nitric oxide synthase, chemistry, biology.protein, Nitric Oxide Synthase, Cardiology and Cardiovascular Medicine, business, Signal Transduction
Abstract: Endothelium-derived nitric oxide (NO) is a mediator of angiogenesis. However, NO-mediated regulation of vasculogenesis remains largely unknown. In the present study, we show that the inhibition of NO significantly attenuated endothelial migration, ring formation, and tube formation. The contribution of nitric oxide synthase (NOS) enzymes during early vasculogenesis was assessed by evaluating endothelial NOS (eNOS) and inducible NOS (iNOS) mRNA expression during HH10–HH13 stages of chick embryo development. iNOS but not eNOS was expressed at HH12 and HH13 stages. We hypothesized that vasculogenic events are controlled by NOS-independent reduction of nitrite to NO under hypoxia during the very early phases of development. Semi-quantitative polymerase chain reaction analysis of hypoxia-inducible factor-1α (HIF-1α) showed higher expression at HH10 stage, after which a decrease was observed. This observation was in correlation with the nitrite reductase (NR) activity at HH10 stage. We observed a sodium nitrite-induced increase in NO levels at HH10, reaching a gradual decrease at HH13. The possible involvement of a HIF/NF-κB/iNOS signaling pathway in the process of early vasculogenesis is suggested by the inverse relationship observed between nitrite reduction and NOS activation between HH10 and HH13 stages. Further, we detected that NR-mediated NO production was inhibited by several NR inhibitors at the HH10 stage, whereas the inhibitors eventually became less effective at later stages. These findings suggest that the temporal dynamics of the NO source switches from NR to NOS in the extraembryonic area vasculosa, where both nitrite reduction and NOS activity are defined by hypoxia.
Published: 2021
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14. Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma

Author: Jayasingham Jayamohan, Hanh Vu, Sarah Leeson, and Puma Sundaresan
Subjects: Adult, medicine.medical_specialty, medicine.medical_treatment, R895-920, radiation therapy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Medical physics. Medical radiology. Nuclear medicine, 0302 clinical medicine, Ocular Adnexal MALT lymphoma, Orbital radiotherapy, Medicine, Humans, Radiology, Nuclear Medicine and imaging, non‐Hodgkin Lymphoma, MALT lymphoma, Aged, Retrospective Studies, Aged, 80 and over, POAML, Radiological and Ultrasound Technology, Performance status, business.industry, Eye Neoplasms, Distant relapse, Dose fractionation, Lymphoma, B-Cell, Marginal Zone, Original Articles, Middle Aged, medicine.disease, Radiation therapy, Regimen, Lymphatic system, 030220 oncology & carcinogenesis, Female, Original Article, Radiology, Dose Fractionation, Radiation, business
Abstract: Introduction Most primary ocular adnexal lymphomas are those involving mucosa‐associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56 Gy) to lower dose RT. We aimed to examine our institution’s experience with the use of orbital RT for treating early‐stage primary ocular adnexal MALT lymphoma (POAML). Methods Patients treated for stage I or II POAML over a 12‐year period (July 2006 to June 2018) were identified through institutional databases. Data were retrospectively collated through review of patient records. Descriptive statistical methods were employed to analyse the data. Results Eighteen patients (median age of 67; range 44‐87yrs) with localised POAML (3 cases of bilateral disease) were identified, resulting in a total of 21 evaluable orbits. Eight (44%) patients were female, and all were documented to be of good performance status (ECOG 0‐1). The median follow‐up was 34 months (range 8‐75 months). The commonest dose fractionation used was 20 Gy in 10 fractions (n = 13 orbits) and a 3D conformal or volumetric modulated arc therapy (VMAT) technique was used in the majority of cases. None of the patients experienced an in‐field recurrence. One patient had experienced a contralateral orbital recurrence two years post‐unilateral orbital RT for orbital MALT lymphoma. Three patients experienced distant relapse. Conclusion The use of lower dose orbital RT such as 20 Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma. The durability of the response appears to be favourable. Given the indolent nature of the disease and the low levels of toxicity associated with lower dose orbital RT, this regimen remains our favoured approach to the management of localised POAML., We aimed to examine our institution’s experience with the use of orbital RT for treating early‐stage primary ocular adnexal MALT lymphoma (POAML).The use of lower dose orbital RT such as 20 Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma.
Published: 2021

15. Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial

Author: Bruce M Biccard, Leon du Toit, Maia Lesosky, Tim Stephens, Landon Myer, Agya BA Prempeh, Nicola Vickery, Hyla-Louise Kluyts, Alexandra Torborg, Akinyinka Omigbodun, Adesoji Ademuyiwa, Muhammed Elhadi, Mohamed Elfagieh, Bernard Mbwele, Mpoki Ulisubisya, Lazaro Mboma, Daniel Z Ashebir, Mahlet Tesfaye Bahta, Mohammed Hassen, Mikiyas Teferi, Yakob Seman, Eugene Zoumenou, Adam Hewitt-Smith, Janat Tumukunde, Dolly Munlemvo, Atilio Morais, Apollo Basenero, Pisirai Ndarukwa, Nazinigouba Ouerdraogo, Maman Sani Chaibou, Mohyeddine Zarouf, Ahmed Rhassane El Adib, Veekash Gobin, Zimogo Sanogo, Youssouf Coulibaly, Zipporah Ngumi, Tarig Fadalla, Cynthia Iradukunda, Vénérand Barendegere, Isaac O Smalle, Mustapha Bittaye, Ahmadou Lamin Samateh, Mahmoud Elfiky, Maher Fawzy, Wakisa Mulwafu, Vanessa Msosa, Lygia Lopes, Akwasi Antwi-Kusi, Hamza D Sama, Patrice Forget, Dawid van Straaten, Rupert M Pearse, Marichen Puchert, Lucy Rolt, Kris Schwebler, Freddy Kabambi, Tebogo Mabotja, Leandys Cobas, Albino Freitas, Maria Antunes, Bartolomeu Cabo, Domingos Paulo, Carlos Camongua, Yvette Avognon, Osseni Marcos, Raymond Kintomonho, Onesime Demahou, Gisèle Hounsa, Hugues Chobli, Elie Fassinou, Aurore Zoglobossou, Blaise Tchaou, Charles Tchegnonsi, Fifame Amadji, Francine Bossa, Ernest Ahounou, Djima Alao, Roushdane Odérémi, Afissatou Montairou, Oswald Gbehade, Romaric Tobome, Adam Boukari, Patrick Bakantieba, Arouna Sambo, Fanou Lionelle, Nounagnon Gilbert, Julien Attinon, Roger Klikpezo, Aumar Dadjo, Dénis Fanou, Gilberte Hounkpe, Bachabi Fafana, Néné Nguilu, Bodourin Dossou-Yovo, Chantal Segla, Mohamed Toko, Evelyne Gnele-Dedewanou, Michel Noukounwoui, Ethienne Yado, Timothé Gouroubéra, Valéry Adjignon, Serge Mewanou, Aïcha Tchomgang, Urielle Agossou, Fernand Soton, Charbel Azanlin, Lidwine Zomahoun, Rawéléguinbasba Armel Flavien Kabore, Salam Savadogo, Fatou Fleur Rosine Sanou, Farid Belém, Victoria Hien, Cheik Tidiane Hafid W Bougouma, Sie Ahmed Ouattara, Mariam Bambara Kabore, Ouedraogo Nazinigouba, Papougnezambo Bonkoungou, Martin Lankoandé, Mireille Traoré, Patrick Sawadogo, Inès Wenmenga, Boureima Kinda, André Simporé, Christian Sapo, Salah Idriss Traore, Haoua Dipama, Lydie WR Kaboré, Salifou Napon, Télesphore G Kaboré, Arouna Louré, Pélagie PP Tondé, Christian Zoundi, Harouna Sanou, Remy Ndikumana, Carlos Nsengiyumva, Gregory Sund, Alliance Niyukuri, Axel Kwizera, Jean-Claude Niyondiko, Adolphe Manzanza Kilembe, Jean Pierre Mwema Ilunga, Nehema Hailemariam Sarah, Gabriel Mubobo Makeya, Idesbald Mwebe Mwepu, Ted Botawaosenge Likongo, Richard Kapela Mvwala, Raphael Nzau Kapend Mubunda, Noellie Kanka Mukuna, Julie Djondo Pembe, Nicolas Lumuanga Ndaye, Eric Bibonge Amisi, Mike Ilunga Madika, Joe Kembo Lungela, Didier Ndonda Mayemba, Philomene Mamba Diyoyo, Alex Mbo Ngalala, Martin Mamba Mukenga, Patricia Tito Kabuni, Dany Bolimo Mpoto, Herve Inesnku Mole, Louise Keby, Oria Andavo Buti, Anselme Phaka, Belinda Mayenge, Jean Jeacques Kabuley Kalongo, Timothe Kemfuni Mawisa, Rodrigue Tondo Ngwizani, Kuyala Leya, Dieudonne Kisile Sanduku, Timothe Nkemfuni Mawisa, Coco Nseke Mfumu, Mbuta Bolenge, Desire Kinzenzengu Kabuce, Patrick Kintieti, Amelia Mbuluku, Vicky Mahuwa, Tharcice Khonde Mabiala, Guilain Ngoy, Patrick Boloko, Nono Mazangama Mvwama, Jose Kengbanda, Pitchou Mushimbonga, Blaise Kuhapala, Nzosani Marcel, Kienze Guylain, Gerard Mboma, Sandra Zalambo Sagboze, Michel Muteya Manika, Jean Pierre Mumbere Kigayi, Roger Mukanire Cishugi, Placide Buhendwa Mugisho, Roger Baguma, Moïse Kongolo, Michel Mandungu Mbayabu, Crispin Mukendi Muamba, Edmond Banema Kapinga, Vasco Ngolela Kapinga, Guylain Tshimanga Nsumpi, Patrick Kanda Odia, Salomon Bingidimi, Gilbert Kpengbemale, Desire Hubert Bofunga Bosonga Imposo, Patricia Matondo, Servet Lelo, Jeremie Kalambayi, Mohamed Abdel-Ghaffar, Abdelrahman Soliman, Mostafa Abdelrahman, Sameh Shehata, Alia Rabee, Mohamed Abou Heba, Mohamed Rabei Abdelfattah, Tamer Ahmed Maher Ghoniem, Sherif M.K. Shehata, Mohamed Lotfy, Ahmed ElHaddad, Bereket Gebremeskel, Girmay Fisseha, Mebrahtu Abay, Degena Bahrey, Assefa Hika, Abdurezak Ali, Kindie Moges, Jemal Ahmed, Desalegn Abdisa, Abebe Megersa, Wendwosen Abayne, Haftom Berhane, Reiye Esayas, Fitsum Kifle, Kokeb Desita, Abebe Addise, Dagim Shimelash, Shitalem Tadesse, Bezaye Zemedkun, Peniel Kenna, Ayenew Yirdie, Abinet Sisay, Tebikew Gashu, Fassil Mihretu, Yesuf Ahmed, Bekele Debebe, Abdureuf Misgea, Amare Agmas, Rahel Assefa, Abdurahman Gelmo, Seifu Alemu, Brook Damtachew, Merid Mersha, Yaekob Chemere, Samuel Fekadu, Sintayehu Regasa, Bonsa Sileshi, Desalegn Wosen, Rebira Adamu, Gersam Mulugeta, Teshome Bacha, Zewude Gudisa, Kebebe Bekele, Alelign Tasew, Habtamu Gezahegn, Daniel Atlaw, Damtew Solomon, Habtemariam Gebresillasie, Girmaye Tesfaye, Negussie Sarbecha, Biniyam Sahiledengle, Kenbon Seyoum, Gemechu Ganfure, Yohannes Tekalegn, Gosa Tesfaye, Temesgen Ayichew, Shibiru Sendaba, Musefa Redwan, Eyasu Muse, Girma Nina, Bizuneh Sime, Addisalem Tadege, Anbesse Jima, Nugusu Ayalew, Dagmawi Workneh, Daniel Teferi, Momodou T Nyassi, Landing N Sanyang, Omar Jallow, Abdoulie Keita, Kitabu Jammeh, Charles Roberts, Patrick Idoko, Kebba Marenah, Masirending Njie, Musa Marena, Karamba Suwareh, Simon Boissey, Fatoumatta Jarjusey, Awa Jah, Awa Sanyang, Dado Jabbi, Kajali Camara, Armando Correa, John Jabang, Lamin Jaiteh, Lamin Dampha, Aminata Manneh, Baboucarr Sowe, Abdoulie Bah, Edrisa Jawo, Victoria Okoje, Momodou Baro, Yaya Bah, Mustapha Njie, Sainabou Mbowe, Ebrima Kanteh, Sarjo Ceesay, Alagie Manneh, Evans Atito-Narh, Adwoa Wilson, Romeo Hussey, Emmanuel Okine, Jemima Kwarteng, Ridge Ntiamoah, Samuel Dadzie, Mark Aseti, Naa Sowah, Akosua Appiah, Charles Bankah, Patrick Mburugu, Thomas Chokwe, Patrick Olang, Vernon Gacii, Susane Nabulindo, Antony Gatheru, Timothy Mwiti, Caroline Mwangi, Julius Muriithi, Daniel Ojuka, Omondi Ogutu, Evans Masitara, Mohamed Chaudhry, Reuben Kamundi, Annmarie Kangangi, Thomas Massaquoi, Stephen Takow, Felister Moraa, Aziz Munubi, Moses Kimani, Adili Wobenjo, Linda Nguu, Vincent Omeddo, Rose Malaba, Ambrose Nabwana, Anita Mwancha, Alexandria Mugaa, John Wamwaki, Joyce Chege, Seymour Sinari, Andrew Ndonga, Rose Shitsinzi, Walter Akello, Winfred Kimani, Elisha Kirwa, Seno Saruni, Andrew Wainaina, Ernest Nshom, Aidah Kenseko, Kizito Shisanya, Purity Wanjiru, Julliah Cherotich, Judy Kimutai, Benson Wahome, Grace Wangui, Dennis Wamalwa, Stephen Mwangi, John Chege, Tabitha Wanjiku, Carolyne Njoki, Wachira Waititu, Conrad Ambani, Samuel Murimi, Sharon Waithira, Nilson Mouti, Collins Kibet, John Kibet, Virginia Sokobe, Beatrice Jeymah, Antony Kamadi, Faith Gichuri, Steve Moses, David Wasike, Favours Adeya, Caesar Bitta, Stephen Ogendo, Killian Kariuki, Hdaya BenAbdalla, Taha Suliaman, Fatima Ali Abokhzam, Mohaned Isa, Mohammed Huwaysh, Asma Bourawi, Kais Alzubaidy, Mohammed Albaraesi, Sumayyah Bahroun, Abdulmueti Alhadi, Ahmed Msherghi, Amira Mohamed, Ala Khaled, Nouran Aljadi, Elham Bareig, Khaled Elgazwi, Adel Elgazwi, Ibrahim El-busife, Safa Owhida, Almahdi Eltwati, Samah Elakeili, Taha Abubaker, Fatima Elkhfeefi, Soha Younis Hasan, Amal Alttaira, Imbarkah Elmraied, Rim Wishah, Omar Abugassa, Hazem Ahmed, Amera Ellafi, Shoukrie Shoukrie, Nawal Aldokali, Aws ElGammudi, Akram Alkaseek, Hoda Elhaddad, Ayyah Alqaarh, Ahlam Brish, Malek Abudsnnuga, Salsabil Albuaishi, Mohammed Albashri, Marwa Morgom, Mohammed Alawami, Eman Shawesh, Abdullah Almabrouk, Moaz Alwarfalli, Nagia Abeid, Anis Buzreg, Ans Malek, Ameerah Abayu, Butaina Abdulhafith, Wedad Abouruwes, Marim Albakuri, Sabria Almuammari, Esam Alsaghair, Fatheia Alreshi, Hassan Badi, Rabiee Alfetoey, Naji Zubia, Bushray Almiqlash, Abdulsalam Alshuhoumi, Rayet Al-islam Ben Jouira, Amaal Dier, Essra Gebril, Mohammed Abdelkabir, Sana Moussa, Marwa Alfitori, Mabroukah Azbeda, Hajar Alamin, Ejmeya Barka, Omlsaad Mosbah, Rema Abdasalam, Miftah Hiyoum, Maryam Abd allateef, Ibrahim Altomi, Mahdi Alsakloul, Ekhlas Karami, Munyah Alriqeeq, Mabruka Omar, Ashraf Samer, Aml Aemeesh, Ahmad Bouhuwaish, Ahmed Elusta, Sultan Ahmeed, Wesal AlFighi Hassan, Mouadah Ali Altayr, Mohamed Addalla, Abrar Geddeda, Kheria Khoja, Doaa Alhaj, Muaad Etturki, Ahmed Elhadi, Ibrahim Ellojli, Anshirah Shuwayyah, Ahmed Elfaghih, Malak Alduwayb, Mohamed Aleiyan, Wedad Aboubreeq, Soliman Alkassem, Sami Ashour, Hayat Ben Hasan, Najat Ben Hasan, Ali Yahya, Palesa Chisala, Edward Kommwa, Lusayo Simwinga, Agness Chalira, Precious Kachitsa, Onias Mtalimanja, Drissa Traoré, Moussa Sissoko, Moussa Camara, Adama Koita, Sekou Koumaré, Omar Sacko, Mahamadou Coulibaly, Lamine Soumaré, Soumaïla Keita, Sidiki Keita, Hamadoun Dicko, Boubacar Diallo, Boureima Bengaly, Mohamed Keita, Siaka Diallo, Drissa Ouattara, Nouhoun Ongoiba, Seydina Beye, Honoré Berthe, Mamadou Diakite, Mamadou Sima, Adégné Togo, Bakary Dembele, Djibo Diango, Moussa Samake, Youssouf Traoré, Louis Traoré, Ongoïba Oumar, Sogoba Gaoussou, Issaga Traoré, Sidy Sangaré, Doua Kanté, Lassana Cissé, Thiam Souleymane, Keita Koniba, Sundaresan Maiyalagan, Julien Chong, Adil Mohit, Khushyant Mungar, Shankaran Vinayagam, Kevin Ramlochun, Jamie Sim, Desai Sneha, Vishaal Kissoon, Yan Tseung, Mohamed Aboobakar, Nitish Fokeerah, Ravi Ramsewak, Jayprakash Gopall, Meetheelesh Abeeluck, Varun Seewoo, Divyanand Jankee, Ashveen Puryag, Senthil Beemadoo, Yashraj Deenoo, Abhisek Goureah, Munawwara Makoon, Hemanshu Rambojan, Beeharry Shanjugsingh, Kevin Viraswami, Shehzaad Joomye, Ashwant Bhugwandass, Bibi Deelawar, Vakil Leelodharry, Luckshmanraj Mungur, Sajid Aungraheeta, Sirsingh Bhajoo, Manpreet Rajcoomar, Rishi Seetaram, Subha Gaya, Gini Batra, Yoshvin Sunnassee, Shailendra Petkar, Sbai Hicham, Labib Smail, Ait Laalim Said, Motaai Youssef, Mouhssine Doumiri, Mustapha Alilou, Nora Farnaoui, Mustapha Bensghir, Abdelghafour Elkoundi, Abdelhamid Jaafari, Abderhmann Elwali, Mohammed Meziane, Walid Atmani, Houssam Rebahi, Hajar Chichou, Safae Zarouf, Abderraouf Soummani, Abou Elhassan Taoufik, Meryem Essafti, Aminata Oumou Traoré, Hamzaoui Hamza, Adnane Berdai, El allani Linda, Salhi Oussama, Nelson Mucopo, Machado Banze, Mouzinho Saide, Tomas Sitoi, Artur Machava, Antonio Carlos, Amilton Guidione, Antonio Saide de Carvalho, Natacha Gemo, Samiro Sema Camal, Arsénio Cuna, Ornelos Madeira, Ladino Assuade, Dercio Amde Fernandes, Dulce Alexandre Machavae Fernandes, Mandua Sebastião, Bernard Sikombe, Matti Kandjimi, Ayoub Shekimweri, Diana Shilomboleni, Mbaundju Kandjii, Leonard Kabongo, Cholastic Hangero, Ike Ndjoze, Ruben Nailonga, Immanuel Uukonga, Uutoni Nakanyala, Lavinia Johannes, Adrian Haruzuvi, Chris Terblanche, Natangwe Shimenda, Delwina Katjipu, Hilma Shalimba, Juliah Kaweendwa, Ali Mbuyi, John Oyedele, Mapumba Mulolo, Peter Njuki, Mutombo Ndaie, Akutu Munyika, Hilma Katangolo, David Tjiyokola, Tawanda Mhene, Archbald Masiambiri, Paidamoyo Mandudzo, Sandra Kapepiso, Haziel Mavesere, Cedia Tjihoto, Daylight Manyere, Charlotte Kauraisa, Learnmore Garanowako, Michael Tune, William DeKlerk, Benvenue Ndolo, Maria Angula, Ndapewoshali Hishekwa, Elizabeth Nandjendja, Elsabe Tsauses, Eunice Mouton, Kudzai Katandawa, Sophia Bruwer, Jaydee Van Staden, Beata Siteketa, Beata Kaholongo, Martha Ntinda, Pueya Nashidengo, Johanna Kandjumbwa, Lahia Lipumbu, Moussa Sirfi, Fouma Djibo, Moutari Mahaman, Abdoulaye Mahaman Bachir, Maikassoua Mamane, Adakal Ousseini, Maman Noury Hamissou Souley, Rabo Oumarou, Rekia Idrissa, Moussa Ichaou, Amina Saley, Abdoulay Seyni, Sahabi Amadou, Mahamane Sani Mahamane Laminou, Issoufou Moustapha Camara, Moussa Gagara, Hadjara Rabiou Daddy, Harissou Adamou, Ibrahim Amadou Magagi, Oumarou Habou, Sabo Ramatou, Saidu Kadas, Rabiu Mohammed, Abubakar Ballah, Tella Olalekan, Kefas Bwala, Mohammed Adamu, Adamu Isa, Ademola Adeyeye, Samuel Fayose, Akinola Akinmade, Taiwo Ajayi, Elizabeth Nwasor, Saidu Yakubu, Euphemia Ugwu, George Mukoro, Muhammed Ahmed, Gideon Akafa, Ahmad Lawal, Daniel Nwoye, Michael Odigbo, Zulaihatu Sarkin-Pawa, Tunde Sholadoye, Benjamin Fomete, Hamisu Yakubu, Abdulkadir Kabiru, Samaila Timothy, Ali Yusuf, Tasiu Saadu, Babangida Mohammed, Abdulghaffar Yunus, Ganiyat Olagunju, Muhammad Aminu, Mohammad Idris, Musliu Tolani, Nasiru Dalhat, Samuel Gana, Talent Adike, Lofty-John Anyanwu, Abdurrahman Sheshe, Sani Aji, Mamuda Atiku, Raphael Attah, Abubakar Muhammed, Rasaki Oseni, Halima Salisu-Kabara, Benjamin Nkemjika, Omotayo Salami, Adekunle Akadri, Bukola Olayinka, Clement Onuoha, Umar Usman Jamaare, Auwalu Saminu Jibrin, Sani Giade Abdullahi, Ibrahim Ishaku, Adenike Odewabi, John Bamigboye, Oladapo Kuforiji, Chidiebere Ogo, Stella Ogunmuyiwa, Abdussemee Abdurrazzaaq, Adebayo Tanimola, Michael Adeyanju, Oluwatimilehin Andero, Temitope Ojo, Olusi Adedotun, Gbadamosi Kehinde, Jimoh Buraimoh, Kabiru Muhammad, Sophia Baidoo, Patrick Okoli, Azeez Adigun, Ekene Ezeonye, Kabir Isa, Yetunde Aremu-Kasumu, Kamil Shoretire, Peter Enesi, Amechi Ezike, Olatunde Olawoye, Emmanuel Ugwu, Christopher Ukah, Abolade Olugbenga, Nwachukwu Chidiebere, Nasiru Abdulraman, Adebiyi Olusegun, Alisa Halisa, Semiat Yusuf, Jamila Salisu, Chidiebube Okoro, Abdul Suleiman, Fabian Onowighose, Aliyu Farinyaro, Suleiman Baba, Umar Abdulmajid, Aisha Abdurrahman, Ogochukwu Obi, Olatunde Alabi, William Adeyemi, Jelili Salau, Jones Taiwo, Nnaemeka Nwafulume, Taiye Ibiyeye, Edith Agu, Ayodeji Danboy, James Abdulazeez, Christopher Ekwunife, Chimaobi Nnaji, Chigozirim Onyekpere, Amara Arunsi, Jude Egwim, Obianuju Nwana, Nnabuike Ojiegbe, Charles Mbamba, Paul Ngwu, Frank Imahigbe, Emmanuel Okoroji, Iloh Ikenna, Abdulrahman Mohammed, Adebayo Adeniyi, Toluwalope Ariyo, Olajide Gabriel, Tesleem Orewole, Salawu Idris, Idowu Adebara, Abiodun Okunlola, Akinwale Akinbade, Oluwasesan Afolabi, Adewumi Bakare, Olabisi Adeyemo, Benjamin Ugwu, Samuel Nuhu, Henry Embu, Erdoo Isamade, Chinedu Obikili, Amaka Ocheke, Solomon Peter, Donald Orshio, Peter Onuminya, Jack Okopi, Olufemi Bankole, Bosede Afolabi, Dapo Osinowo, Ayodeji Oluwole, Muyiwa Rotimi, Ibironke Desalu, Rufus Ojewola, Bolaji Mofikoya, Kola Owonikoko, Adeolu Adeoye, Temidayo Bobo, Taiwo Akinloye, David Ama, Ebere Okoronkwo, Muhammad Mahmud, Jamiu Adebiyi, Temitope Babalola, Mansur Muhammad, Afeez Aruna, Maryrose Osazuwa, Ayodeji Yusuf, Isiaka Lawal, Bitrus Fidelis, Rephath Pius, Cyril Jomosu, Adebayo Adedayo, Abubakar Aliyu, Adaora Agholor, Abdullateef Abdulazeez, Chabiya Bala, Eziamaka Eze, Elizabeth Ani, Uchenna Okeke, Dominica Adebayo, Okechukwu Ekwunife, Victor Modekwe, Chuka Ugwunne, Chukwuemeka Okoro, Chisom Uche, Simeon Olateju, Fred Ige-Orhionkpaibima, Adedapo Adetoye, Olurotimi Aaron, Jeremiah Abimbola, Folayemi Faponle, Olumuyiwa Ajayeoba, Olusoji Jagun, Oluwabunmi Fatungase, Adeniyi Akiseku, Chigbundu Nwokoro, Ramotalai Shoyemi, Ibukunolu Ogundele, Nankat Joseph, Salihu Bura, Chukwuka Nwezoku, Manu Bwala, Meshach Philips, Abubakar Usman, Emmanuel Filibus, Zara Umate, Nwabuoke Chukwuka, Ahmed Nuhu, Watakiri Ibrahim, James Nggada, Ali Izge, Musa Ismail, Olayinka Eyelade, Tinuola Adigun, Babatunde Osinaike, Olayinka Ogunbode, Olusola Idowu, Taiwo Lawal, Temidayo Ogundiran, Olayiwola Shittu, Omobolaji Ayandipo, Stephen Edino, Zumnan Songden, Olumide Akitoye, Bissallah Ekele, Godwin Akaba, Terkaa Atim, Akitoye Adeleke, Owoicho Okochi, Sunday Akeju, Ernest Ukpoju, Osayomwanbo Osaheni, Ifunanya Obaseki, Lateef Kehinde, Osawemwenze Monday, Stanley Nte, Adesuwa Agboifo, Omajuwa Dawodu, Precious Orhiere, David Atiti, Queeneth Kalu, Felix Effiom, Israel Kolawole, Olawale Ojo, Afusat Olabinjo, Olufemi Ige, Beatrice Ogunyemi, Olusola Oladosu, Kikelomo Adesina, Sulaiman Agodirin, Asimiyu Shittu, Audu Idrisa, Sadiq Adamu, Nuhu Ali, Olayinka Adewunmi, Stephen Nwankwor, Akinwumi Olakanmi, Oluseye Ajayi, Ayotolu Ajayi, Victor Ogunmola, Oluwafunke Olakanmi, Adam Kuranga, Enoch Uche, Chukwuemeka Osuagwu, Chukwudi Ilo, Mesi Matthew, Uko Uko, Ngozi Mba, Olubusola Alagbe-Briggs, Amabra Dodiyi-Manuel, Bisola Onajin-Obembe, Bright Obasuyi, Richard Echem, Ihuoma Mike-Elechi, Job Otokwala, Mark Edubio, Catherine Eyo, Isaac Udo, Aliyu Abdulrahman, A.A. Abdullahi, Ibrahim Galadima Bello, Usman Adinoyin Mohammed, Abidemi Oyaromade, Mohammed Bello, Usman Muhammad, Emeri Mbah, Hyacinth Okereke, Almustapha Aminu, Anthony Ahmadu, Abu Rogers, Peter Samai, Sao Amara, Margaret Yankuba, Mary Josayah, Jayah Swarray Jnr, Alusine Dawo, Peter George, Mustapha Kabba, Mohamed Bah, Charles Mondeh, Ibrahim Kapuwa, Mohamed Sheku, Philip Mattia, Brima Sesay, Jones O.A. Omoshoro-Jones, Motselisi Mbeki, Estie Cloete, Philip Anderson, Busi Mrara, Annemarie Steyn, Tsakani Mhlari, Nic Proctor, Caroline Robertson, Gillian Lamacroft, Usha Singh, Sebenzile Sikhakhane, Kelly Gate, Shepherd Nzenza, John Tshimbalanga Kasonga, Sibongile Ndebele, Patrick Lufuta Kande, Jody Davids, Tino-vito Orlandi, Marischka de Jong, Hugo Stark, Francois Roodt, Jonathan Hall, Ian Nortje, Akanimo Akpakan, Vishendran Govindasamy, Ronisha Sathiram, Mohammad Kathrada, Zane Farina, Lucio Frittella, Charles Kohler, Sibuyiselwe Lubelwana, Sarwat Ikram-Hameed, Adriaan Smit, Muneerah Cassiem, Yvonne Freeman, Saaliha Goga, Larissa Cronje, Constantin Buzdugan, Subash Chirkut, Priyadeshni Singh, Sandhya Jithoo, Vivesh Rughubar, John Arnold, Rishan Bipath, Suman Mewa Kinoo, Ncumisa Khanyisa Msolo, Fleur Ackermans-Deijnen, Tshegofatso Mmasello Emma Boka, Martyn Biccard Greenwood, Shakthi Anand Jayrajh, Devarani Naidoo, Syndrini Reddy, Devandiran Harriraman Rungan, Kylene Subrayen, John Roos, Nina Tredoux, Pascal Plumacher, Anthony Reed, Harald Steinhaus, Mariesa Nock, Paul Ryan Herselman, Gareth Davies, Talitha Harvey, Franklin Muller, Willem Naude, Tania Pretorius, Johan Jochemus Swart, Merryn Walls, Prashant Gokal, Nicolette Rorke, Farzaana Dhoodhat, Precious Dzanibe, Mohammed Yusuf Hussain, Ashmita Junpath, Ameela Maharaj, Hylda Makanisi, Khalid Moosa, Ting Ting Wong, Sean Mould, Trisha Ramsamy, Roel Matos-Puig, Hayley Morgan, Nadeem Nabeebuccas, Ria Devi Naidoo, Viantha Pather, Vasheel Vasheel Bahadur, Renilda Pillay, Zahnne Fullerton, Nicole Bell, Bongisa Grey, Vincent Lorenzo Visentin, Hendrik Adriaan Van Zyl, Terri Anne Killingbeck, Emile Maneveldt, Gerhard Thiart, Magdelena May Venter, Oostewalt Swart, Mariette Grobelaar, Carel Cairns, David Bishop, Christien Steenkamp, Thandekile Khumalo, Noel Naidoo, Ross Murray, Martin Kopieniak, Melusi Sishange, Mxolisi Brian Ndimande, Megan Jaworska, Sarwat Ikram, Bence Rainier, Renier J Liebenberg, Helena D Zwiegers, Philip M Nortje, Kamal Bhagwan, Margot Flint, Robert Dyer, Simone Adams, Yoshua Bwambale, Danny Ngomo, Patrice Kanku, Nivashen Pillay, Alexa de Castro, Atisha Maharaj, Janine Carim, Jenna Leigh Taylor, Karl M Köhne, Leanne W Drummond, Leanne Temlett, Lieze Geldenhuys, Yvonne Seilbea, Kathryn Naidoo, Nicola A Kalafatis, Stefné Verwey, Thulile Biyase, Theroshnie Kisten, Belinda S Kusel, Timothy Craig Hardcastle, Richard Magagula, Christian Kampik, Kuzolunga Xulu, Sivuyisiwe Solala, Mia Sayed, Basil Enicker, Anil Madaree, Innocent Mukama, Gladmore Madombwe, Nonhlanhla Zulu, Nompumelelo Gasa, Nokuzula Kanjana, Sebenzile Buthelezi, Thembelihle Buthelezi, Andries Brink, Francois Potgieter, Busisiwe Mrara, Zaynab Alexander, Charles Choto, Paula Ima, Zintle Gxagxisa, Baphethuxolo Ningiza, Gillian Lamacraft, Jerome Mogorosi, Nadia du Plessis, Leonie de Man, Suné Thompson, Gerrit van Heerden, Edwin W Turton, Pieter M van der Linde, Josephine K Teme-Pitse, Reitumetse Tladi, Gillian D Saffy, Ene-Mari Roscher, Kristel Fortune, George Barnard, Tiisetso Makhasane, Evan Bowen, Akangcha Pal, Rachel Moore, Maria Fourtounas, Mary Augusta Adam, Renessa Arumugan, Gabriella Hyman, Jaclyn Jonosky, Maninginingi Makondo, Heveshan Moodley, Phillip Munda, Mzwandile Nyalungu, Victor Olusola, Sohan Zane Pinto, Tristan Pillay, Lucinda Singh, Paul Mwindekuma Wondoh, John Devar, Boitumelo Baloyi-Mnisi, Zach Koto, Matlou Ernest Mabitsela, Sibongile Ruth Ndlovu, Branny Mthelebofu, Colin Beck, Matthew Dold, Alice Fan, Shannon MacQueen, Thembani Matabata, Catherine Mpehle, Charné Kulenkampf, Tsakani McCreath Mhlari, Simangele Cecilia Nyoka-Mokgalong, Felix Thumba Masinge, Randhir Ramnath Gunpath, Maropeng Petrus Pat Mothwa, Jo-Anne Asenath Mothwa, Danai Mhlanga, Jamie-Lyn Colly, Aunel Mallier Peter, Khalid Ben Hameda, Pulane Mokae, Stella Josephine Moumakoe, Kelechi Ekeh, Nezingu Lengo, Marnus Booyens, Inge Louise Seale, Pieter Daniel Theron, Nicolaas Abraham Schuman, Amber Carlyn Sonn, Jacobus Lukas Stander, Nadia Cloete, Marius Cloete, Catherine Ann Makepeace, Ronel van der Westhuizen, Leanne Robyn Messiahs, Amy Ruth Visagie, Fatima Vawda, Frans Christiaan Voster, Deepika Dhilraj, Oliver Smith, Stefan Bolon, Daniel Montwedi, Motsilisi Mbeki, Jayde Wyngaard, Mthunzi Ngcelwane, Thomas Kleyenstuber, Phyllis Phukubye, Liesel Schärf, Grace Laker, Elizabeth Semenya, Reinhard Dembskey, Thomas Tarlton, Tapiwa Jiri, Ngoie Hubert Mushid, Nhlanhla Samuel Ngwenya, Hazel Morongoa Mogodi, Carmen Sinevici, Anthony Osarogie Usenbo, Naledi Fodo, Anesu Chimini, Ntetelelo Sikobi, Sinovuyo Nokwange, Mluleki Noqhamza, Qumba Thembisa, Kajake Anantha Padmanabha Bhat, Rabin Mathew, Katrin Middleton, Abdus-sami Adewunmi, Craig Dickson, Humairah Bulbulia, Bianka Bester, Michelle de Klerk, Christia Benade, Francois Viljoen, Monique Fischer, Khalid Alfaki, Abdalmalik Awad, Abdelsalam Algray, Mohammed Elsiddig, Suha Mohamed, Salih Mahmoud, Muhammed Osman, Asia Elgailany, Mazin Suliman, Hanaa Mohammed, Lina Aljeally, Mohammed Dirar, Mohammed Osman, Mazin Mohamed, Mohamed Elhasan, Abrar Widatalla, Abubakr Abubakr, Eman Mohamed, Alshareef Nour, Ntonto Doris Gama, Dolorosa Khetsiwe Shabangu, Cynthia Iradikunda, Samuel Mkoko, Paul Kisanga, Emmanuel Lema, Benson Lyimo, Mohamed Binde, Alphonce Chandika, Salim Salim, Sylvia Jumbe, Abel Makubi, Vihar Kotecha, Felician Kachinde, Museleta Nyakiroto, Emmanuel Jitambi, Venant Geofrey, Johaphes Josiah, Phinius Makubi, Frank Manumbu, Suzan Mlingwa, Ernest Ibenzi, Peter Mbelle, Kato Peleus, Enid Chiwanga, Nillah Richard, Shoo Leonard, Paulo Sanka, Subira Mushi, Bashir Nyangasa, Mohamed Janabi, Naizihijwa Majani, Pedro Palangyo, Evarist Nyawawa, William Ramadhan, Faraj Lydenge, Gileard Gabriel Masenga, Sakina Rashid, Mubashir Jusabani, Ansbert Ndebea, Jenitha Cheru, Margaret Henjewele, Greyson Kilimanjaro, Sarah Sikimata, Deocles Donatus, Hazina Maduhu, Tumaini Mariro, Given Massasi, Moshi Moshi Shabani, Braison Cholela, Marco Mgeleka, Yohatinus Mbilinyi, Faraja Chiwanga, Bilton Exavery, Caspar Haule, Samson Ndile, Sirili Harya, Julieth Magandi, Deogratius Manyama, Redempta Matindi, Adam Moshi, Daudi Kitwana, Merida Makia, Philip Muhochi, Miriam Herman, Clauda Miombo, Furaha Kahindo, Langtone Kishebuka, Elijah Ussiri, Gloria Kinasa, Patrick Adel, Eric Malaba, Vensesla Sakwari, Sadot Lugereka, Mohamed Mungia, George Mocha, Herman Wella, Cecilia Protas, Patrick Karua, Ahmada Kashagama, Faraja Mwasambugu, Suzana Kajeri, Jacquiline Mchilla, Elibariki Lucumay, Robert Maise, Amon Marti, Beatrice Mahundi, Frederika Jager, Charles Majani, Ludovick Rukeha, Tareeq Mohamed, Nabila Fuad, Winifrida Halinga, Elias Chrisant, Gilbert Msoma, Titus Kihwili, Gadiel Temu, Naima Yusuf, Rashid Saleh, Rashid Inoja, Eva Shang'a, Stella Ibrahim, Hussein Msuma, Edwin Edward, Paul Kilamile, Stephen Mwakyolile, Talkana Adja, Edem Gueouguede, Hafoudhoi Oussene Seddoh, Saliou Adam, Pilakimwe Egbohou, Mawunyo Ahomagnon, Olivier Kadjossou, Abdul-Bassiti Boukari, Mary T Nabukenya, Ruth Muhindo, Peter Waswa, Peter Kaahwa Agaba, Daphne Kabatoro, Joseph Kayong, Margaret Naggujja, Nabasiige Rehema, Phiona Nansubuga, Daniel Kavuma, Aggrey Lubikire, Hope Bisilikirwa, Godfrey Ssebaggala, Emmanuel Muwema, Humble Joan Agaba, John Kiconco, Nicholas Wataaka, Bonet Chan, Mary Juliet Nampawu, Fred Bulamba, Emmanuel Bua, Christine Mugala, Caroline Nyakato, John Paul Ochieng, Linda Kyomuhendo Jovia, George Kateregga, Rachel Alum, Lazia Najjuma, Gorret Nampiina, Andrew Kintu, Joshua Sempiira, Luzige Simon, Peter Kayima, Jacob Eyul, Erick Odwar, Rita Nkwine, Christine Namata, Elizabeth Nabakka, Denis Kakaire, Velda Mushangwe-Mtisi, Erisha Munhamo, Celestino Dhege, Juliet Hungwa, Hemish Jasi, Crispin Ntoto, Derek Matsika, Brightson Mutseyekwa, Joseph Zimbovoora, Beaulah Gudyanga, Dennis Mazingi, Chenesa Mbanje, Busisiwe Mlambo, Michael Chiwanga, Harunavamwe N Chifamba, Sarudzai Zhou, Esta Hove, Shamiso Dende, Beauty Manjengwa, Penias Kapisa, null Mashava, Caritas Chiura, Locadia Katsukunya, Godfrey Muguti, Doreen Mashava, Elton Ndhlovu, Zanele Mangwangwa, and Nombulelo Dube
Subjects: Adult, medicine.medical_specialty, Standard of care, business.industry, Psychological intervention, MEDLINE, Standard of Care, General Medicine, Articles, Hospitals, Hospitalization, Intervention (counseling), Relative risk, Emergency medicine, Africa, medicine, Humans, In patient, Female, Cluster randomised controlled trial, Postoperative Period, business, Surgical patients
Abstract: Summary Background Risk of mortality following surgery in patients across Africa is twice as high as the global average. Most of these deaths occur on hospital wards after the surgery itself. We aimed to assess whether enhanced postoperative surveillance of adult surgical patients at high risk of postoperative morbidity or mortality in Africa could reduce 30-day in-hospital mortality. Methods We did a two-arm, open-label, cluster-randomised trial of hospitals (clusters) across Africa. Hospitals were eligible if they provided surgery with an overnight postoperative admission. Hospitals were randomly assigned through minimisation in recruitment blocks (1:1) to provide patients with either a package of enhanced postoperative surveillance interventions (admitting the patient to higher care ward, increasing the frequency of postoperative nursing observations, assigning the patient to a bed in view of the nursing station, allowing family members to stay in the ward, and placing a postoperative surveillance guide at the bedside) for those at high risk (ie, with African Surgical Outcomes Study Surgical Risk Calculator scores ≥10) and usual care for those at low risk (intervention group), or for all patients to receive usual postoperative care (control group). Health-care providers and participants were not masked, but data assessors were. The primary outcome was 30-day in-hospital mortality of patients at low and high risk, measured at the participant level. All analyses were done as allocated (by cluster) in all patients with available data. This trial is registered with ClinicalTrials.gov , NCT03853824 . Findings Between May 3, 2019, and July 27, 2020, 594 eligible hospitals indicated a desire to participate across 33 African countries; 332 (56%) were able to recruit participants and were included in analyses. We allocated 160 hospitals (13 275 patients) to provide enhanced postoperative surveillance and 172 hospitals (15 617 patients) to provide standard care. The mean age of participants was 37·1 years (SD 15·5) and 20 039 (69·4%) of 28 892 patients were women. 30-day in-hospital mortality occurred in 169 (1·3%) of 12 970 patients with mortality data in the intervention group and in 193 (1·3%) of 15 242 patients with mortality data in the control group (relative risk 0·96, 95% CI 0·69–1·33; p=0·79). 45 (0·2%) of 22 031 patients at low risk and 309 (5·6%) of 5500 patients at high risk died. No harms associated with either intervention were reported. Interpretation This intervention package did not decrease 30-day in-hospital mortality among surgical patients in Africa at high risk of postoperative morbidity or mortality. Further research is needed to develop interventions that prevent death from surgical complications in resource-limited hospitals across Africa. Funding Bill & Melinda Gates Foundation and the World Federation of Societies of Anaesthesiologists. Translations For the Arabic, French and Portuguese translations of the abstract see Supplementary Materials section.
Published: 2021

16. Optimization and Deep Learning–Based Content Retrieval, Indexing, and Metric Learning Approach for Medical Images

Author: Kumar T. Ananth, S. Sundaresan, Kumar K. Suresh, and R. Nishanth
Subjects: Information retrieval, Content retrieval, Computer science, business.industry, Deep learning, Metric (mathematics), Search engine indexing, Artificial intelligence, business
Published: 2021
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17. The burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population: Results from a statewide sentinel-based population survey in Karnataka, India

Author: Lalitha R, Vinitha Thakar, Siddesh Kc, Prameela Dinesh, Rajesh Sundaresan, Asish Satapathy, Jawaid Akhtar, Mysore Kalappa Sudarshan, Mythri Ba, Ravi Vasanthapuram, Mohammed Shariff, Kumar D E Vasanth, Gopalkrishna Gururaj, C N Manjunath, Lalitha Krishnappa, Pankaj Kumar Pandey, M Rajagopal Padma, H.G. Sreedhara, Pradeep Banandur, Deepa Ravi, Shantala Gowdara Basawarajappa, Nawaz Umar, Giridhara R Babu, Amrutha Kumari B, Ashok Munivenkatappa, Ambica Rangaiah, Anita Desai, Parimala S Maroor, Siva Athreya, Eunice Lobo, Shilpa Shiju, Lokesh Alahari, Krishna S, and Timmanahalli Sobagaiah Ranganath
Subjects: 0301 basic medicine, Microbiology (medical), Cross-sectional study, 030106 microbiology, Population, India, Infectious and parasitic diseases, RC109-216, Antibodies, Viral, Asymptomatic, Article, Immunoglobulin G, Herd immunity, 03 medical and health sciences, 0302 clinical medicine, Karnataka, Environmental health, Case fatality rate, Prevalence, Humans, Medicine, 030212 general & internal medicine, education, education.field_of_study, biology, SARS-CoV-2, business.industry, Sentinel survey, COVID-19, Antibody testing, General Medicine, Stratified sampling, Cross-Sectional Studies, Infectious Diseases, biology.protein, Antibody, medicine.symptom, business
Abstract: Objective To estimate the burden of active infection and anti-SARS-CoV-2 IgG antibodies in Karnataka, India, and to assess variation across geographical regions and risk groups. Methods A cross-sectional survey of 16,416 people covering three risk groups was conducted between 3–16 September 2020 using the state of Karnataka’s infrastructure of 290 healthcare facilities across all 30 districts. Participants were further classified into risk subgroups and sampled using stratified sampling. All participants were subjected to simultaneous detection of SARS-CoV-2 IgG using a commercial ELISA kit, SARS-CoV-2 antigen using a rapid antigen detection test (RAT) and reverse transcription-polymerase chain reaction (RT-PCR) for RNA detection. Maximum-likelihood estimation was used for joint estimation of the adjusted IgG, active and total prevalence (either IgG or active or both), while multinomial regression identified predictors. Results The overall adjusted total prevalence of COVID-19 in Karnataka was 27.7% (95% CI 26.1–29.3), IgG 16.8% (15.5–18.1) and active infection fraction 12.6% (11.5–13.8). The case-to-infection ratio was 1:40 and the infection fatality rate was 0.05%. Influenza-like symptoms or contact with a COVID-19-positive patient were good predictors of active infection. RAT kits had higher sensitivity (68%) in symptomatic people compared with 47% in asymptomatic people. Conclusion This sentinel-based population survey was the first comprehensive survey in India to provide accurate estimates of the COVID-19 burden. The findings provide a reasonable approximation of the population immunity threshold levels. Using existing surveillance platforms coupled with a syndromic approach and sampling framework enabled this model to be replicable.
Published: 2021
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18. Heat transfer analysis in fin and tube exchanger using CFD

Author: M. Ravikumar, P. Pandiarajan, Arunraja K.M, Radha Krishnan Beemaraj, and Sundaresan R
Subjects: Pressure drop, Work (thermodynamics), Materials science, business.industry, Heat transfer, Heat exchanger, Tube (fluid conveyance), Thermal transfer, Mechanics, Computational fluid dynamics, business, Fin (extended surface)
Abstract: The designs of fine tubes and thermal exchangers rely on the fabrication of copper and aluminum fin and tube heat exchangers. The heat was regulated through copper tubes and pipes by flowing water. The major objective of this work will be to enhance the rate of heat transmission by altering the existing tube and finish. The copper U-tube was replaced with the spline fin in the heat exchanger in this project. Pressure drop, speed, and heat transfer properties of the heat exchanger were evaluated using solid works and the study was conducted using computer fluid dynamics (CFD). From the results, it has been determined that the improvement of thermal transfer rate and efficiency in spline fin is up to 5 percent higher than the flat fin and also increases pressure and the higher pumping power in a heat exchanger by placing fluid within the fin through cross-flow.
Published: 2022
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19. Reputation and regulations: evidence from eBay

Author: Hui, Xiang, Saeedi, Maryam, Shen, Zeqian, and Sundaresan, Neel
Subjects: eBay Inc. -- Marketing, Online information services -- Marketing, Online services -- Marketing, Information asymmetry -- Analysis, Information services -- Marketing, Company marketing practices, Online information service, Business, general, Business
Abstract: To mitigate inefficiencies arising from asymmetric information, some markets rely on government interventions, whereas others rely on reputation systems, warranties, or guarantees. This paper explores the impact of two mechanisms, [...]
Published: 2016
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20. AI-enabled knowledge sharing and learning: redesigning roles and processes

Author: Shankar Sundaresan and Zuopeng Zhang
Subjects: Organizational Behavior and Human Resource Management, Knowledge management, business.industry, Process (engineering), Computer science, Strategy and Management, 05 social sciences, 020206 networking & telecommunications, 02 engineering and technology, Knowledge sharing, 0502 economics and business, 0202 electrical engineering, electronic engineering, information engineering, business, 050203 business & management
Abstract: Purpose This paper aims to investigate the role of AI in facilitating knowledge sharing and learning in organizations and the redesign of AI-enabled knowledge workers’ roles and processes. Design/methodology/approach This paper develops a framework for analyzing AI’s role in different knowledge management activities, explores the impact of AI in transforming knowledge workers’ roles and processes in knowledge sharing and learning and presents recommendations for tailored AI-enabled knowledge management systems for modern knowledge worker environments. Findings The authors synthesize the elements from different parts of the relevant literature and develop a unified framework consisting of three dimensions of AI systems, three knowledge management (KM) activities and two types of AI–human interactions. Based on this framework, the authors summarize the primary use cases supported by AI-enabled knowledge management systems (KMS) and compare them with the traditional KMS use cases. The authors find that a single type of AI system is insufficient to support the increasingly complex nature of knowledge workers’ activities, manifested in three dimensions – process, engagement and content; a tailored AI system should be developed to support knowledge workers in their unique roles and processes. Originality/value With the growing interest in AI and its applications to KM, this research provides managerial insights for practitioners to effectively adopt AI in managing knowledge assets in organizations.
Published: 2021
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21. Evaluation of endocrine resistance using ESR1 genotyping of circulating tumor cells and plasma DNA

Author: Erin J. Silva, Daniel A. Haber, Taronish D. Dubash, Shyamala Maheswaran, Ravi Kapur, Matthew Liebers, Nicola Aceto, Zongli Zheng, Douglas B. Fox, John Iafrate, Ben S. Wittner, Mehmet Toner, Aditya Bardia, and Tilak K. Sundaresan
Subjects: 0301 basic medicine, Cancer Research, Genotype, Estrogen receptor, Breast Neoplasms, medicine.disease_cause, Article, Circulating Tumor DNA, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Circulating tumor cell, Humans, Medicine, Digital polymerase chain reaction, Prospective Studies, Aromatase, Genotyping, Mutation, biology, business.industry, Estrogen Receptor alpha, Neoplastic Cells, Circulating, medicine.disease, Metastatic breast cancer, body regions, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Neoplasm Recurrence, Local, business
Abstract: PURPOSE: Therapeutic efficacy of hormonal therapies to target estrogen receptor (ER)-positive breast cancer is limited by the acquisition of ligand-independent ESR1 mutations, which confer treatment resistance to aromatase inhibitors (AIs). Monitoring for the emergence of such mutations may enable individualized therapy. We thus assessed CTC- and ctDNA-based detection of ESR1 mutations with the aim of evaluating non-invasive approaches for the determination of endocrine resistance. PATIENTS AND METHODS: In a prospective cohort of 55 women with hormone receptor-positive metastatic breast cancer, we isolated circulating tumor cells (CTCs) and developed a high-sensitivity method for the detection of ESR1 mutations in these CTCs. In patients with sufficient plasma for the simultaneous extraction of circulating tumor DNA (ctDNA), we performed a parallel analysis of ESR1 mutations using multiplex droplet digital PCR (ddPCR) and examined the agreement between these two platforms. Finally, we isolated single CTCs from a subset of these patients and reviewed RNA expression to explore alternate methods of evaluating endocrine responsiveness. RESULTS: High-sensitivity ESR1 sequencing from CTCs revealed mono- and oligoclonal mutations in 22% of patients. These were concordant with plasma DNA sequencing in 95% of cases. Emergence of ESR1 mutations was correlated both with time to metastatic relapse and duration of AI therapy following such recurrence. The Presence of an ESR1 mutation, compared to ESR1 wild type, was associated with markedly shorter Progression-Free Survival on AI-based therapies (p = 0.0006), but unaltered to other non-AI-based therapies (p = 0.73). Compared with ESR1 mutant cases, AI-resistant CTCs with wild-type ESR1 showed an elevated ER-coactivator RNA signature, consistent with their predicted response to second-line hormonal therapies. CONCLUSION: Blood-based serial monitoring may guide the selection of precision therapeutics for women with AI-resistant ER-positive breast cancer.
Published: 2021
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22. Whole-Exome Sequencing Reveals Novel TSPAN12 Variants in Autosomal Dominant Familial Exudative Vitreoretinopathy

Author: Xianjun Zhu, Shujin Li, Lulin Huang, Mu Yang, Zhenglin Yang, Periasamy Sundaresan, Rulian Zhao, and Chen Chen
Subjects: 0301 basic medicine, Genetics, business.industry, Retinal, General Medicine, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, TSPAN12, chemistry, 030220 oncology & carcinogenesis, Familial exudative vitreoretinopathy, Medicine, business, Genetics (clinical), Exome sequencing
Abstract: Background: Familial exudative vitreoretinopathy (FEVR), a group of rare inherited retinal vascular disorders, is the major cause of vision loss in juveniles. At present, the diagnosis of FEVR rema...
Published: 2021
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23. Prophylaxis for patients at Risk to Eliminate Post-operative Atrial Fibrillation (PREP-AF trial): a protocol for a feasibility randomized controlled study

Author: Dean Ferguson, Sebastien Gilbert, Greg Sigler, Salmaan Kanji, Diem Tran, Donna E. Maziak, Heather Smith, Tori Lenet, Sudhir Sundaresan, Calum J. Redpath, Andrew J.E. Seely, and Patrick James Villeneuve
Subjects: medicine.medical_specialty, Medicine (General), Population, Amiodarone, Medicine (miscellaneous), 030204 cardiovascular system & hematology, Placebo, law.invention, Study Protocol, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, R5-920, Randomized controlled trial, law, Atrial Fibrillation, Humans, Multicenter Studies as Topic, Medicine, Pharmacology (medical), Postoperative Period, education, Adverse effect, Randomized Controlled Trials as Topic, education.field_of_study, business.industry, Prophylaxis, Prevention, Atrial fibrillation, medicine.disease, Postoperative atrial fibrillation, Clinical trial, Thoracic surgery, 030228 respiratory system, Cardiothoracic surgery, Emergency medicine, Feasibility Studies, business, Anti-Arrhythmia Agents, Arrhythmia, medicine.drug
Abstract: Background Postoperative atrial fibrillation (POAF) is a frequent adverse event after thoracic surgery with associated morbidity, mortality, and healthcare costs. It has been shown to be preventable with prophylactic amiodarone, which is only recommended in high-risk individuals due to the potential associated side effects. Risk factors for POAF have been identified and incorporated into a prediction model to identify high-risk patients. Further evaluation in the form of a multicenter clinical trial is required to assess the effectiveness of prophylaxis specifically in this high-risk population. The feasibility of such a trial first needs to be assessed. Methods The PREP-AF trial is a double-blind randomized controlled feasibility trial. Individuals undergoing major thoracic surgery who are identified to be high-risk by the POAF prediction model will be randomized 1:1 to receive a short course of amiodarone vs. placebo in the immediate postoperative period. The primary outcome is feasibility, which will be measured by the number of eligible patients identified, consented, and randomized; intervention adherence; and measurement of future outcomes of a full trial. Discussion This study will determine the feasibility of a randomized controlled trial to assess the effectiveness of prophylactic amiodarone, in high-risk patients undergoing major thoracic surgery. This will inform the development of a multi-center trial to establish if prophylactic amiodarone is safe and effective at reducing the incidence of POAF. Preventing this adverse event will not only improve outcomes for patients but also reduce the associated health resource utilization and costs. Trial registration ClinicalTrials.gov NCT04392921. Registered on 19 May 2020.
Published: 2021

24. Impacts of Gastrojejunal Anastomotic Technique on Rates of Marginal Ulcer Formation and Anastomotic Bleeding Following Roux-en-Y Gastric Bypass

Author: Kyle J. Thompson, B. Amy Hiticas, Iain H. McKillop, Selwan Barbat, Keith S. Gersin, Timothy S. Kuwada, Mariel Sullivan, Naresh Sundaresan, Lauren Poliakin, Abdelrahman Nimeri, and Benedict Y Hui
Subjects: medicine.medical_specialty, Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Incidence (epidemiology), Upper endoscopy, Gastric bypass, 030209 endocrinology & metabolism, Anastomosis, Eea stapler, Roux-en-Y anastomosis, Gastroenterology, Marginal Ulcer, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, 030211 gastroenterology & hepatology, Surgery, business, Anastomotic bleeding
Abstract: Marginal ulceration (MU) and bleeding are possible complications following laparoscopic Roux-en-Y gastric bypass (RYGB). Our institution utilizes three techniques for performing the gastrojejunal anastomosis (GJA), providing a means to compare postoperative MU and bleeding as it relates to GJA technique. We sought to analyze the incidence of MU and bleeding between the 25-mm end-to-end anastomosis (EEA) stapler, linear stapler (LS), and robotic hand-sewn (RHS) GJA techniques. Electronic health records for all patients who had an upper endoscopy (EGD) after RYGB were queried (2010–2014). Charts were retrospectively reviewed for type of GJA, complications, endoscopic interventions, and smoking and NSAID use. Out of 1112 RYGBs, the GJA was created using an EEA, LS, or RHS approach in 58.6%, 33.6%, and 7.7% of patients, respectively. 17.4% had an EGD (19.9% EEA, 13.9% LS, and 14.0% RHS). Incidence of MU was 7.3% (9.3% EEA, 4.8% LS, and 5.8% RHS). Rates of EGD and MU were significantly higher after EEA vs. LS GJA (p
Published: 2021
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25. Clinical exome sequencing facilitates the understanding of genetic heterogeneity in Leber congenital amaurosis patients with variable phenotype in southern India

Author: Vijayalakshmi Perumalsamy, Rupa Anjanamurthy, Periasamy Sundaresan, Devarajan Bharanidharan, Ayyasamy Vanniarajan, and Sriee Viswarubhiny
Subjects: 0301 basic medicine, Retinal degeneration, Candidate gene, Genotype-phenotype correlation, medicine.disease_cause, Leber congenital amaurosis, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Retinitis pigmentosa, medicine, Exome, Exome sequencing, Genetics, Sanger sequencing, Mutation, Genetic heterogeneity, business.industry, Research, RE1-994, medicine.disease, Southern India, eye diseases, Clinical exome sequencing, Ophthalmology, 030104 developmental biology, 030221 ophthalmology & optometry, symbols, sense organs, Molecular diagnosis, business
Abstract: Background Leber congenital amaurosis (LCA), primarily characterized by retinal degeneration is the most severe form of inherited retinal dystrophy (IRD) responsible for congenital blindness. The presence of phenotypic heterogeneity makes the diagnosis of LCA challenging, especially in the absence of pronounced disease pathognomonic, yet it can be well comprehended by employing molecular diagnosis. Therefore, the present study aimed to reveal the causative mutations in ten LCA patients with variable phenotypes using clinical exome sequencing (CES). Methods CES was performed in ten unrelated LCA patients. Ophthalmic information and family history of all patients were obtained to make a meaningful interpretation. The clinical exome data was analyzed and prioritized using a bioinformatics pipeline to identify mutations, which was further validated by Sanger sequencing. Segregation analysis was also performed on available family members. Results CES led to the identification of causative mutations in nine LCA patients. Seven patients harbored a mutation in six LCA candidate genes, including RPE65, LCA5 (n = 2), CRX, PRPH2, CEP290, and ALMS1, while two patients possess a mutation in IFT80 and RP1, known to cause other diseases. Three novel mutations in LCA5 (c.1823del), CRX (c.848del) and CEP290 (c.2483G > T) were identified. The current study reports for the first time, a mutation in PRPH2, CEP290, and ALMS1 from the Indian population. Additionally, we observed a novel association of LCA phenotype with IFT80 known to cause Jeune syndrome. Based on the genetic finding, the patient AS09, who harbored a mutation in the RP1 gene, was re-diagnosed with early-onset retinitis pigmentosa. Conclusion In conclusion, the results underline the importance of CES in clinically diagnosed LCA patients with variable phenotypes. The correlation between mutations in candidate genes and clinical phenotypes, helps to refine the clinical diagnosis. However, molecular evaluation with a larger cohort of LCA patients is needed for better understanding of the mutational spectrum in southern India.
Published: 2021

26. Underwriting Government Debt Auctions: Auction Choice and Information Production

Author: Suresh Sundaresan, Sudip Gupta, and Rangarajan K. Sundaram
Subjects: TheoryofComputation_MISCELLANEOUS, Government, 050208 finance, Strategy and Management, 05 social sciences, Government debt, TheoryofComputation_GENERAL, Management Science and Operations Research, Commerce, Bid shading, 0502 economics and business, Production (economics), Common value auction, Business, 050207 economics, Underwriting
Abstract: In this paper, we examine a novel two-stage mechanism for selling government securities, wherein the dealers underwrite in the first stage the sale of securities, which are auctioned in stage 2 via either a discriminatory auction (DA) or a uniform price auction (UPA). Using proprietary data on auctions during 2006–2013, we find that (a) the first stage underwriting auction generates significant information, including predicting the likelihood of devolvement, and bid shading, and (b) the outcome of the underwriting auction may generate enough asymmetry amongst bidders that may make DA dominate UPA in certain counterfactual situations. We document that the unique two-stage auction design provides a market-driven mechanism to simultaneously insure against auction failures and produce information about the quality of the underlying issue. This paper was accepted by Karl Diether, finance.
Published: 2021
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27. Modeling of VANET for Future Generation Transportation System Through Edge/Fog/Cloud Computing Powered by 6G

Author: A.S. Radha Mani, S. Sundaresan, T. Ananth Kumar, and K. Suresh Kumar
Subjects: Vehicular ad hoc network, Smart transportation, Computer science, business.industry, Real-time computing, Cloud computing, Enhanced Data Rates for GSM Evolution, business
Published: 2021
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28. A Microbiota-Directed Food Intervention for Undernourished Children

Author: Cyrus Zhou, Jeffrey I. Gordon, Arjun S. Raman, Michael J. Barratt, Martin Meier, Sayeeda Huq, Daniel M. Webber, Vinaik Sundaresan, Tahmeed Ahmed, Matthew C. Hibberd, Nurun Nahar Naila, Mustafa Mahfuz, Subhasish Das, Robert Y. Chen, M Ashraful Alam, Kazi Badrul Ahsan, Mahabub U Zaman, Ishita Mostafa, and M Munirul Islam
Subjects: Extramural, business.industry, General Medicine, 030204 cardiovascular system & hematology, medicine.disease, Body weight, Article, law.invention, 03 medical and health sciences, Malnutrition, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), Environmental health, medicine, 030212 general & internal medicine, business, Infant Nutritional Physiological Phenomena
Abstract: BACKGROUND More than 30 million children worldwide suffer from moderate acute malnutrition (MAM). Current treatments have limited effectiveness and much remains unknown about pathogenesis. Children with MAM exhibit perturbed development of their gut microbiota. METHODS Slum-dwelling Bangladeshi children, aged 12 to 18 months, with moderate acute malnutrition (n=124) received a microbiota-directed complementary food (MDCF-2) or an existing ready-to-use supplementary food (RUSF), twice daily for three months followed by a 1-month period of monitoring. We obtained weight-for-length, weight-for-age, and length-for-age Z-scores and mid-upper arm circumference at baseline and fortnightly, through four months. We compared the rate of change of these related phenotypes between baseline and three months, and between baseline and four months. We also measured levels of 4,977 proteins in plasma plus 209 bacterial taxa in fecal samples. RESULTS 118 children completed the intervention (n=59/arm). The rate of change in weight-for-length Z-score (β-WLZ), weight-for-age Z-score, and mid upper arm circumference is consistent with a benefit of MDCF-2 on growth over the course of the study including the one-month follow-up. Receipt of MDCF-2 was linked to the magnitude of change in levels of 70 β-WLZ-positively correlated plasma proteins including mediators of bone growth, neurodevelopment and inflammation (gene set enrichment analysis [GSEA];p
Published: 2021

29. Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats

Author: Govindan Sadasivam Selvam, Balakrishnan Saravanan, Varadaraj Vasudevan, Sundaresan Sasikumar, Subramani Yuvaraj, and Tharmarajan Ramprasath
Subjects: Male, 0301 basic medicine, Very low-density lipoprotein, medicine.medical_specialty, Nitric Oxide Synthase Type III, NF-E2-Related Factor 2, Clinical Biochemistry, Diet, High-Fat, medicine.disease_cause, Nitric oxide, Rats, Sprague-Dawley, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oral administration, Enos, Internal medicine, medicine, Animals, Chrysin, Molecular Biology, Flavonoids, biology, medicine.diagnostic_test, business.industry, Myocardium, Cell Biology, General Medicine, biology.organism_classification, Rats, Up-Regulation, Oxidative Stress, 030104 developmental biology, Endocrinology, chemistry, 030220 oncology & carcinogenesis, lipids (amino acids, peptides, and proteins), business, Lipid profile, Oxidative stress
Abstract: Hypercholesterolemia is one of the risk factors associated with increased morbidity and mortality in cardiovascular disorders. Chrysin (Chy) is reported to exhibit anti-inflammatory, anti-cancerous, anti-oxidative, anti-aging, and anti-atherogenic properties. In the present study, we aimed to investigate whether Chy would mediate the cardioprotective effect against hypercholesterolemia-triggered myocardial oxidative stress. Male Sprague Dawley rats were divided into different groups as control and fed with high-fat diet (HFD) followed by oral administration of Chy (100 mg/kg b.wt), atorvastatin (Atv) (10 mg/kg b.wt), and L-NAME (10 mg/kg b.wt) for 30 days. At the end of the experimental period, the rats were sacrificed and tissues were harvested. Biochemical results showed a significant increase of cardiac disease marker enzymes (ALT, AST, and CKMB), lipid peroxidation, and lipid profile (TC, TG, LDL, and VLDL) in HFD-fed rat tissues when compared to control, whereas oral administration of Chy significantly reduced the activities of these marker enzymes and controlled the lipid profile. qRT-PCR studies revealed that Chy administration significantly increased the expression of endothelial nitric oxide synthase (eNOS), and Nrf2 target genes such as SOD, catalase, and GCL3 in left ventricular heart tissue of HFD-challenged rats. Immunohistochemistry results also showed that Chy treatment increased myocardial protein expression of eNOS and Nrf2 in HFD-challenged rats. Concluding the results of the present study, the Chy could mediate the cardioprotective effect through the activation of eNOS and Nrf2 signaling against hypercholesterolemia-induced oxidative stress. Thus, the administration of Chy would provide a promising therapeutic strategy for the prevention of HFD-induced oxidative stress-mediated myocardial complications.
Published: 2021
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30. Extra-Hepatic Biliary Obstruction - A Cross-Sectional Study to Assess the Various Benign and Malignant Causes for Obstructive Jaundice among Patients Attending Trivandrum Medical College

Author: Preetha Sundaresan, K S Swasthik, and Varun Vijayan
Subjects: 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, Cross-sectional study, business.industry, 030220 oncology & carcinogenesis, Internal medicine, medicine, 030211 gastroenterology & hepatology, Obstructive jaundice, business
Abstract: BACKGROUND Extra-hepatic biliary tract obstruction can be due to a number of conditions. Most causes are due to stones in the common biliary duct or due to malignant obstruction. Malignant causes include carcinoma head of pancreas, periampullary carcinoma and cholangiocarcinoma. Besides calculus and malignant obstruction, benign and malignant strictures can also cause obstruction of extra hepatic biliary ducts. The objectives of the study were to describe the clinical profile of patients presenting with extra-hepatic biliary obstruction and to assess the known aetiological factors. METHODS The research was designed as a hospital based cross-sectional study in the general surgery wards of our institution from 2016 to 2017. All individuals who were diagnosed to have extra-hepatic biliary obstruction by imaging were included in the study. RESULTS Among the 66 cases studied, majority were due to malignancies and gall stones. The malignancies included carcinoma head of pancreas, periampullary carcinoma, cholangiocarcinoma and Klatskin’s tumour. Miscellaneous causes were bile duct stricture, cholelithiasis with biliary sludge and annular pancreas. For the malignant cases, Whipple surgery and its pylorus-preserving variant were the most common surgical procedures carried out. Biliary bypass procedures were also carried out in some patients. For patients with common bile duct (CBD) stones, cholecystectomy, choledocholithotomy and choledochojejunostomy were done. CONCLUSIONS Malignant causes of jaundice are more common than benign causes. Secondary stones are the commonest cause of non-malignant biliary obstruction. Jaundice is more severe and associated with pruritis and more intolerable and persistent in malignancy. Surgical bypass procedures give good palliation for obstructive jaundice. KEY WORDS Bile Ducts, Choledocholithiasis, Cholestasis, Extra Hepatic, Pancreatic Cancer, Periampullary Cancer
Published: 2021
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31. MRI radiomics in the prediction of therapeutic response to neoadjuvant therapy for locoregionally advanced rectal cancer: a systematic review

Author: Harriet E. Gee, Eric Hau, Y. Sun, Angelina Di Re, Annette Haworth, James Wei Tatt Toh, Michelle Or, and Purnima Sundaresan
Subjects: 0301 basic medicine, medicine.medical_specialty, Standard of care, Colorectal cancer, medicine.medical_treatment, Frequency of use, Mri studies, 03 medical and health sciences, 0302 clinical medicine, Primary outcome, Radiomics, medicine, Humans, Pharmacology (medical), Neoadjuvant therapy, medicine.diagnostic_test, Rectal Neoplasms, business.industry, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Neoadjuvant Therapy, Treatment Outcome, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Radiology, business
Abstract: Introduction: The standard of care for locoregionally advanced rectal cancer is neoadjuvant therapy (NA CRT) prior to surgery, of which 10-30% experience a complete pathologic response (pCR). There has been interest in using imaging features, also known as radiomics features, to predict pCR and potentially avoid surgery. This systematic review aims to describe the spectrum of MRI studies examining high-performing radiomic features that predict NA CRT response.Areas covered: This article reviews the use of pre-therapy MRI in predicting NA CRT response for patients with locoregionally advanced rectal cancer (T3/T4 and/or N1+). The primary outcome was to identify MRI radiomic studies; secondary outcomes included the power and the frequency of use of radiomic features.Expert opinion: Advanced models incorporating multiple radiomics categories appear to be the most promising. However, there is a need for standardization across studies with regards to; the definition of NA CRT response, imaging protocols, and radiomics features incorporated. Further studies are needed to validate current radiomics models and to fully ascertain the value of MRI radiomics in the response prediction for locoregionally advanced rectal cancer.
Published: 2021
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32. Variation in management of post-operative atrial fibrillation (POAF) after thoracic surgery

Author: Paul J. Villeneuve, Sudhir Sundaresan, Heidi Oi-Yee Li, Donna E. Maziak, Olivier Brandts-Longtin, Andrew J.E. Seely, Heather Smith, and Sebastien Gilbert
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Atrial fibrillation, General Medicine, Perioperative, 030204 cardiovascular system & hematology, medicine.disease, Cardiac surgery, Discontinuation, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Cardiothoracic surgery, Anesthesia, medicine, Surgery, Cardiology and Cardiovascular Medicine, Adverse effect, business, Stroke, Cohort study
Abstract: New-onset post-operative atrial fibrillation (POAF) is a frequent adverse event following major thoracic surgery and is associated with increased risk of perioperative morbidity, length of stay and stroke. It is managed initially with rate and rhythm control therapy; however, optimal duration and the need for anticoagulation are poorly understood. This study aims to assess practice variation regarding POAF management and duration. This retrospective, single-center cohort study included patients who underwent major thoracic surgery and developed POAF between 2008 and 2017, managed with rate and rhythm control therapy alone. Demographic, clinical, and surgical variables/outcomes, POAF management, and incidence of POAF recurrence in the 30-day post-operative period were collected. Chi-square and T-tests determined significance. Of 2054 patients undergoing thoracic surgery, 155 (75%) patients developed POAF. Different rate and rhythm control agents were used, most commonly metoprolol. 107 (69%) continued rate and rhythm control therapy upon hospital discharge for a mean of 56 days. Among the 48 patients with discontinuation of rate and rhythm control therapy on discharge, none demonstrated recurrence of POAF; in contrast to 3 of 107 patients who continued on therapy. Among patients with CHA2DS2-VASc score ≥ 2, 15% were prescribed anticoagulation on discharge. Use of rate and rhythm control therapy and anticoagulation for POAF is significantly varied in practice. Many patients are not continued on rate and rhythm control after hospital discharge, which does not appear to impact risk of POAF recurrence. Further research to inform guidelines for POAF management, including therapy duration and indications for anticoagulation is warranted.
Published: 2021
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33. Whole-exome sequencing identifies multiple pathogenic variants in a large South Indian family with primary open-angle glaucoma

Author: Mohideen Abdul Kader, Renagappa Ramakrishnan, Subbiah. R. Krishnadas, Manojkumar Kumaran, Prakash Chermakani, Mohd Hussain Shah, Periasamy Sundaresan, and Bharanidharan Devarajan
Subjects: Candidate gene, primary open-angle glaucoma, genetic structures, Glaucoma, arghef40 gene, genetic heterogeneity, Tonometry, Ocular, symbols.namesake, Exome Sequencing, Genetic variation, Humans, Medicine, rpgrip1 south indian, whole-exome sequencing, Family history, Eye Proteins, Gene, Intraocular Pressure, Exome sequencing, Genetics, Sanger sequencing, Special Focus, Glaucoma, Original Article, business.industry, Genetic heterogeneity, RE1-994, medicine.disease, eye diseases, Ophthalmology, Mutation, symbols, sense organs, business, Glaucoma, Open-Angle
Abstract: Purpose To identify the pathogenic variants associated with primary open-angle glaucoma (POAG) using whole-exome sequencing (WES) data of a large South Indian family. Methods We recruited a large five-generation South Indian family (n = 84) with a positive family history of POAG (n = 19). All study participants had a comprehensive ocular evaluation. We performed WES for 16 samples (nine POAG and seven unaffected controls) since Sanger sequencing of the POAG candidate genes (MYOC, OPTN, and TBK1) showed no genetic variation. We used an in-house pipeline for prioritizing the pathogenic variants based on their segregation among the POAG individual. Results We identified one novel and five low-frequency pathogenic variants with consistent co-segregation in all affected individuals. The variant c.G3719A in RPGR-interacting domain of RPGRIP1 that segregated heterozygously with the six POAG cases is distinct from variants causing photoreceptor dystrophies, reported affecting the RPGR protein complex signaling in primary cilia. The cilia in trabecular meshwork (TM) cells has been reported to mediate the intraocular pressure (IOP) sensation. Furthermore, we identified a novel c.A1295G variant in Rho guanine nucleotide exchange factors Gene 40 (ARHGEF40) and a likely pathogenic variant in the RPGR gene, suggesting that they may alter the RhoA activity essential for IOP regulation. Conclusion Our study supports that low-frequency pathogenic variants in multiple genes and pathways probably affect Primary Open Angle Glaucoma's pathogenesis in the large South Indian family. Furthermore, it requires larger case-controls to perform family-based association tests and to strengthen our analysis.
Published: 2021

34. A review on energy generation from manure biomass

Author: M. Nagaraja, R. Sundaresan, C. Sasikumar, and C. Rajaganapathy
Subjects: 010302 applied physics, Global energy, Waste management, Moisture, business.industry, Biomass, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Manure, Renewable energy, Electricity generation, 0103 physical sciences, Environmental science, Animal waste, Electricity, 0210 nano-technology, business
Abstract: Solid biomass with high carbon content such as dried manure can be burnt after moisture removal to heat water for any processing and to drive gas turbines to generate electricity. Biomass energy has potential to contribute 45%–55% of total global energy requirements. Biomass energy contributes a major source of renewable energy since it will not pollute the environment by emission of toxic gases and traces of other metal elements. This paper focuses on utilization of manure biomass as a base fuel for power generation in villages where surplus animal wastes can be extracted and processed. The technical aspects of gasification using animal manures as a source of biomass fuel is described with an awareness to gas cleaning requirements to maintain environmental standards. The main idea of present research is to demonstrate the feasibility of generation electricity from animal residues using the concepts of gasification process. Also the present works addresses the possible technical breakthroughs.
Published: 2021
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35. Predicting the structural, electronic and magnetic properties of few atomic-layer polar perovskite

Author: Jinrong Cheng, N. V. Ter-Oganessian, Shixun Cao, Shunbo Hu, Alexander P. Pyatakov, Jincang Zhang, Fanhao Jia, Shaowen Xu, Wei Ren, and A. Sundaresan
Subjects: Condensed Matter - Materials Science, Materials science, Condensed matter physics, business.industry, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, General Physics and Astronomy, 02 engineering and technology, Computational Physics (physics.comp-ph), 021001 nanoscience & nanotechnology, 01 natural sciences, Chemical formula, Semiconductor, Ferromagnetism, 0103 physical sciences, Polar, Density functional theory, Physical and Theoretical Chemistry, 010306 general physics, 0210 nano-technology, business, Physics - Computational Physics, Stoichiometry, Perovskite (structure), Surface states
Abstract: Density functional theory (DFT) calculations are performed to predict the structural, electronic and magnetic properties of electrically neutral or charged few-atomic-layer (AL) oxides whose parent systems are based on polar perovskite $KTaO_{3}$. Their properties vary greatly with the number of ALs ($n_{AL}$) and the stoichiometric ratio. In the few-AL limit ($n_{AL}\leqslant 14$), the even AL (EL) systems with chemical formula $(KTaO_{3})_{n}$ are semiconductors, while the odd AL (OL) systems with formula ($K_{n+1}Ta_{n}O_{3n+1}$ or $K_{n}Ta_{n+1}O_{3n+2}$) are half-metal except for the unique $KTa_{2}O_{5}$ case which is a semiconductor due to the large Peierls distortions. After reaching certain critical thickness ($n_{AL}>14$), the EL systems show ferromagnetic surface states, while ferromagnetism disappears in the OL systems. These predictions from fundamental complexity of polar perovskite when approaching the two-dimensional (2D) limit may be helpful for interpreting experimental observations later., Phys. Chem. Chem. Phys., 2021
Published: 2021
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36. Assess the prearrest risk factors among patients with in hospital cardiac arrest in a tertiary care teaching hospital

Author: Sundaresan S, Akila Devi A, and Kanniammal C
Subjects: medicine.medical_specialty, Framingham Risk Score, business.industry, Mortality rate, medicine.disease, Sepsis, Heart failure, Internal medicine, medicine, Chi-square test, Myocardial infarction, General Pharmacology, Toxicology and Pharmaceutics, Prospective cohort study, business, Depression (differential diagnoses)
Abstract: This study focused on the prearrest risk factors among patients with in hospital cardiac arrest. This was a prospective study with 50 cardiac arrest patients who fulfilled the inclusion criteria by using a purposive sampling technique. Data was collected on patient characteristics, pre-arrest factors with 18 years of age or above with an IHCA at the SRM General Hospital and Research Centre, Tamil Nadu from March 2019 to March 2020. Demographic variables categorized by frequencies with their percentages. Association was framed between demographic variables and Prearrest risk score was determined using pearson chisquare test. 72% patients were men and 28% patients were women. 28% were in the age group of 51-60 years and around 50% patients were Obese. Patients with Myocardial Infarction were 84%. Metabolic and electrolyte abnormality were 90%, Arrhythmias were 62%, Diabetes Mellitus were 62% had an increased risk score to develop cardiac arrest than other patients with Renal problems, Heart failure, Sepsis, Pneumonia, Metastasis/ Hematologic Malignancy, Depression, Hepatic Insufficiency. Early identification of prearrest factors should be encouraged to prevent cardiac arrest and to reduce the death rate in line with evidence-based studies.
Published: 2020
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37. SkyCore

Author: Sampath Rangarajan, Karthikeyan Sundaresan, Z. Morley Mao, Mehrdad Moradi, and Eugene Chai
Subjects: General Computer Science, Computer science, Distributed computing, Interoperability, Core network, Distributed management, ComputerApplications_COMPUTERSINOTHERSYSTEMS, 02 engineering and technology, Base station, 0203 mechanical engineering, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, Forwarding plane, Wireless, ComputerSystemsOrganization_SPECIAL-PURPOSEANDAPPLICATION-BASEDSYSTEMS, Mobility management, General Environmental Science, Radio access network, business.industry, Network packet, 020302 automobile design & engineering, 020206 networking & telecommunications, Hotspot (Wi-Fi), Key (cryptography), General Earth and Planetary Sciences, Enhanced Data Rates for GSM Evolution, Robust control, business, 5G, Computer network
Abstract: The advances in unmanned aerial vehicle (UAV) technology have empowered mobile operators to deploy LTE (long-term evolution) base stations (BSs) on UAVs and provide on-demand, adaptive connectivity to hotspot venues as well as emergency scenarios. However, today's evolved packet core (EPC) that orchestrates LTE's radio access network (RAN) faces fundamental limitations in catering to such a challenging, wireless, and mobile UAV environment, particularly in the presence of multiple BSs (UAVs). In this work, we argue for and propose an alternate, radical edge EPC design, called SkyCore that pushes the EPC functionality to the extreme edge of the core network---collapses the EPC into a single, lightweight, self-contained entity that is colocated with each of the UAV BS. SkyCore incorporates elements that are designed to address the unique challenges facing such a distributed design in the UAV environment, namely the resource constraints of UAV platforms, and the distributed management of pronounced UAV and UE mobility. We build and deploy a fully functional version of SkyCore on a two-UAV LTE network and showcase its (i) ability to interoperate with commercial LTE BSs as well as smartphones, (ii) support for both hotspot and stand-alone multi-UAV deployments, and (iii) superior control and data plane performance compared to other EPC variants in this environment.
Published: 2020
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38. Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract

Author: Preeti Gupta, Maryam Hazly Hilmy, Jie Jin Wang, Jiemin Liao, Allan Fong, Maria K. Swift, Johanna M. Colijn, Paul Mitchell, Ya Xing Wang, Anita S Y Chan, Barbara E.K. Klein, Pirro G. Hysi, Jaeyoon Chung, Emily Y. Chew, Wanting Zhao, Yang Shen, Ava Grace Tan, Hengtong Li, Eranga N. Vithana, Gyungah Jun, Wenting Liu, Tin Aung, Qiao Fan, Yuan Shi, Ekaterina Yonova-Doing, Soon-Phaik Chee, Sudha K. Iyengar, Yik Ying Teo, Periasamy Sundaresan, Chiea Chuen Khor, Zheng Li, Kathryn P. Burdon, Miao Ling Chee, Yih Chung Tham, Christopher J Hammond, Xiaoran Chai, Kerrin S. Small, Queenie S. Tan, Jacqueline Chua, Jost B. Jonas, Astrid E. Fletcher, Alexessander Couto Alves, Pieter W.M. Bonnemaijer, Ravilla D. Ravindran, Mei Chin Lee, Milly S. Tedja, Robert P. Igo, Kristine E. Lee, Tien Y Wong, Xinyi Su, Caroline C W Klaver, Xueling Sim, Ching-Yu Cheng, Chaolong Wang, Lars G. Fritsche, Epidemiology, and Ophthalmology
Subjects: 0301 basic medicine, Genotype, genetic structures, QH301-705.5, Medicine (miscellaneous), Genome-wide association study, Disease, Bioinformatics, Polymorphism, Single Nucleotide, Genome-wide association studies, Cataract, Article, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Genetic variation, Humans, Medicine, Genetic Predisposition to Disease, Allele, Biology (General), Alleles, Genetic Association Studies, Genetic association, business.industry, SOXB1 Transcription Factors, Genetic Variation, medicine.disease, eye diseases, 030104 developmental biology, Age-related nuclear cataract, 030221 ophthalmology & optometry, Congenital cataracts, Lens diseases, sense organs, General Agricultural and Biological Sciences, business, Genome-Wide Association Study
Abstract: Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h2 = 0.48), but little is known about specific genetic factors underlying this condition. Here we report findings from the largest to date multi-ethnic meta-analysis of genome-wide association studies (discovery cohort N = 14,151 and replication N = 5299) of the International Cataract Genetics Consortium. We confirmed the known genetic association of CRYAA (rs7278468, P = 2.8 × 10−16) with nuclear cataract and identified five new loci associated with this disease: SOX2-OT (rs9842371, P = 1.7 × 10−19), TMPRSS5 (rs4936279, P = 2.5 × 10−10), LINC01412 (rs16823886, P = 1.3 × 10−9), GLTSCR1 (rs1005911, P = 9.8 × 10−9), and COMMD1 (rs62149908, P = 1.2 × 10−8). The results suggest a strong link of age-related nuclear cataract with congenital cataract and eye development genes, and the importance of common genetic variants in maintaining crystalline lens integrity in the aging eye., Here, the authors report a multi-ethnic genome wide association meta-analysis of 12 studies from the International Cataract Genetics Consortium. They find six new loci associated with age-related nuclear cataract, in addition to replicating the association at CRYAA, and suggest a strong genetic link between age-related nuclear and congenital cataracts.
Published: 2020

39. Congenital pancreaticobiliary anomalies in an urban medical center in the United States

Author: Choichi Sugawa, Ashley Culver, Naresh Sundaresan, and Charles E. Lucas
Subjects: choledochal cyst, medicine.medical_specialty, endoscopic retrograde cholangiopancreatography, 03 medical and health sciences, 0302 clinical medicine, medicine, Choledochal cysts, Cyst, pancreas divisum, Pancreas divisum, Endoscopic retrograde cholangiopancreatography, treatment, Hepatology, medicine.diagnostic_test, business.industry, Gallbladder, Gastroenterology, Original Articles, Annular pancreas, medicine.disease, medicine.anatomical_structure, Pancreaticobiliary maljunction, 030220 oncology & carcinogenesis, Cystic duct, Original Article, pancreaticobilary anomalies, 030211 gastroenterology & hepatology, Radiology, business, pancreaticobiliary maljunction
Abstract: Background and Aim Pancreaticobiliary anomalies are rare and often present with cryptic signs and symptoms, thus delaying appropriate treatment. Methods Endoscopic retrograde cholangiopancreatography (ERCP) was used to define pancreaticobiliary anomalies. A retrospective review was performed of 5522 ERCPs conducted at a tertiary care center from 1972 to 2015. Results There were 249 (4.5%) patients with pancreaticobiliary anomalies, including 179 patients with pancreas divisum (PD), 44 patients with choledochal cyst (CC) (Todani's classification Type I: extrahepatic cyst 31, Type III; choledochocele 9, Type V: Caroli's disease 4), 20 patients with anomalous pancreaticobiliary ductal union (APDU), and 6 patients with other abnormalities. Of 179 patients with pancreas divisum, 8 (4.5%) required minor sphincterotomies for multiple unexplained acute pancreatitis. Of the 31, 15 (48%) Type I CC patients underwent an operation. In patients with Type III CC (choledochocele), seven of the nine were treated by endoscopic sphincterotomy, and two patients were treated by surgery. Four patients with Type V CC (Caroli's disease) were managed nonoperatively. Of the 20 patients with APDU, 8 (40%) required operative intervention. Six patients were found to have other anomalies: two with pancreas bifidum, one with a duplication of the gallbladder, one with a cystic duct diverticulum, one with an annular pancreas, and one with an abnormal cystic duct origin. These patients were treated based on their etiology. Conclusion Pancreaticobiliary anomalies are rare and can be defined using ERCP. The appreciation of these abnormalities is important for the proper diagnosis and treatment of these rare biliary and pancreatic disorders., Pancreaticobiliary anomalies were analyzed using endoscopic retrograde cholangiopancreatography (5522 patients) in an urban medical center in the United States. A total of 249 (4.5%) patients were found to have a pancreaticobiliary anomaly. There were 179 patients with pancreas divisum, 44 patients with choledochal cyst, 20 patients with anomalous pancreaticobiliary ductal union, and 6 patients with other abnormalities.
Published: 2020
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40. Postoperative Adverse Events are Associated with Oncologic Recurrence Following Curative-intent Resection for Lung Cancer

Author: Andrew J.E. Seely, Hilalion Ahn, Zach Zhang, Farid M. Shamji, Patrick James Villeneuve, Sebastien Gilbert, Donna E. Maziak, Stephen Gowing, Sudhir Sundaresan, Emma J.M. Grigor, Caitlin Anstee, Jelena Ivanovic, Alexandre Tran, and Laura Baker
Subjects: Pulmonary and Respiratory Medicine, Curative intent, medicine.medical_specialty, Proportional hazards model, business.industry, Hazard ratio, Disease, medicine.disease, Confidence interval, Resection, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Internal medicine, Medicine, 030212 general & internal medicine, business, Lung cancer, Adverse effect
Abstract: Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. The association between AEs, particularly infectious in nature, and disease recurrence is controversial. We sought to evaluate the association of postoperative AEs on risk of developing recurrence and recurrence-free survival (RFS) following curative-intent lung resection surgery. All lung cancer resections at a single institution (January 2008–July 2015) were included, with prospective collection of AEs using the Thoracic Morbidity & Mortality System. Cox proportional hazards models were used to estimate the effect of AEs on recurrence, with results presented as hazard ratio (HR) with 95% confidence interval (CI). An a priori, clinically driven approach to predictor variable selection was used. Kaplan–Meier curves were used examine the relationship between AE and RFS. p
Published: 2020
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41. Prevalence and Pattern of Geographic Atrophy in Asia

Author: Shih-Jen Chen, Marco Yu, Prabhat Nangia, Se Woong Kang, Jonathan C.H. Chan, Suganeswari Ganesan, Chui Ming Gemmy Cheung, Xiaohui Yang, Praveen Vashist, Gyulli M. Kazakbaeva, Ramasamy Kim, Charumathi Sabanayagam, Vaitheeswaran Kulothungan, Pei Quan Zhao, Astrid E. Fletcher, Jost B. Jonas, Fumihiko Matsuda, Rajiv Raman, Tung-Mei Kuang, Ravilla D. Ravindran, Kohta Fujiwara, Kenji Yamashiro, Nattapol Pokawattana, Ronnie George, Raba Thapa, Achareeya Saenmee, Rohit C Khanna, Kyu Hyung Park, Akitaka Tsujikawa, Tien Yin Wong, Jie Hao, Jae Pil Shin, Masahiro Miyake, Sang Jun Park, Kai Cao, Feifei Mao, Tarun Sharma, Ningli Wang, Songhomitra Panda-Jonas, Janani Surya, Ayako Takahashi, Takamasa Kayama, Timur R. Gilmanshin, Hyun Woong Kim, Ching-Yu Cheng, Jaeryung Oh, Ya Xing Wang, Tyler Hyungtaek Rim, Wen Bin Wei, Hiroyuki Namba, Watanee Jenchitr, Toru Takebayashi, Ryo Kawasaki, Sei Harada, Mariko Sasaki, Mukharram M. Bikbov, Koh Hei Sonoda, Periasamy Sundaresan, Qianli Meng, Vinay Nangia, Ian Y. H. Wong, Yasuo Yanagi, Hidetoshi Yamashita, Paisan Ruamviboonsuk, Usha Chakravarthy, Rinat M. Zainullin, Yih Chung Tham, Timur A. Khalimov, Seung-Young Yu, and G.H.M.B. van Rens
Subjects: 0303 health sciences, medicine.medical_specialty, education.field_of_study, business.industry, Population, Macular degeneration, medicine.disease, Confidence interval, Pallor, Geographic atrophy, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, Meta-analysis, Epidemiology, 030221 ophthalmology & optometry, medicine, East Asia, medicine.symptom, education, business, 030304 developmental biology, Demography
Abstract: Purpose Although there have been many population-based studies of age-related macular degeneration (AMD), only limited information is available in Asia on the epidemiology of geographic atrophy (GA). We aimed to determine the prevalence and patterns of GA through an analysis of multiple studies conducted within the Asian Eye Epidemiology Consortium (AEEC). Design Cross-sectional meta-analyses. Participants A total of 97 213 individuals aged 40 years and older. Methods Data from 22 population-based studies from countries belonging to the AEEC were included. In all studies, AMD was defined on the basis of standardized grading systems. Geographic atrophy was defined as an area of pallor in the fundus with visibility of the underlying choroidal blood vessels and sharply defined borders. Random-effects meta-analysis was performed to estimate overall and age-, gender-, and region-specific pooled prevalence of GA. Main Outcome Measures Prevalence of GA per 1000 persons. Results The mean age was 60.8 ± 10.0 years, and 42 673 (43.9%) were male. Overall, a total of 223 individuals (0.2%) had GA. The pooled overall prevalence of GA was 1.57 per 1000 persons (95% confidence interval [CI], 1.04–2.10), which was 3 times less than that of neovascular AMD of 5.20 per 1000 persons (95% CI, 3.97–6.43). Compared with those aged 50 to 59 years, the prevalence of GA increased from 0.34 per 1000 persons (95% CI, 0.07–0.62) to 2.90 per 1000 persons (95% CI, 1.55–4.25) in those aged ≥70 years. The GA prevalence per 1000 persons was similar between urban (2.22; 95% CI, 1.22–3.23) and rural residents (1.33; 95% CI, 0.70–1.96). Geographic atrophy was more prevalent in South Asia (based on studies from India and Nepal, 3.82 per 1000 persons; 95% CI, 1.72–5.93) compared with East Asia (based on studies from China, Korea, Hong Kong, Taiwan, and Japan, and the Singapore Chinese Eye Study, 0.76 per 1000 persons; 95% CI, 0.31–1.22, P = 0.005). Conclusions Geographic atrophy is uncommon in Asian populations compared with those of European ancestry. Even within Asia, geographic differences in GA prevalence were seen. The findings of this meta-analysis suggest that better dissection of risk factors in the Asian population for GA may provide insights into the biological pathways that drive these late-stage manifestations, thus suggesting better targets for prevention.
Published: 2020
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42. Examining the Hispanic paradox in bariatric surgery

Author: Kyle J. Thompson, Iain H. McKillop, Naresh Sundaresan, Selwan Barbat, Amanda Roberts, and Abdelrahman Nimeri
Subjects: Adult, medicine.medical_specialty, Sleeve gastrectomy, medicine.medical_treatment, Gastric Bypass, Bariatric Surgery, 030209 endocrinology & metabolism, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Matched cohort, Gastrectomy, medicine, Humans, Univariate analysis, Hispanic paradox, business.industry, Incidence (epidemiology), medicine.disease, Comorbidity, Obesity, United States, Obesity, Morbid, Surgery, Laparoscopy, 030211 gastroenterology & hepatology, Complication, business
Abstract: The obesity rate for the Hispanic population is significantly higher than that of white, non-Hispanic people in the United States, yet Hispanic people undergo disproportionately fewer metabolic and bariatric surgery procedures. This study used the Metabolic Bariatric Surgery Accreditation and Quality Improvement Program data registry to examine potential differences in preoperative co-morbidities and postoperative outcomes in Hispanic adults undergoing sleeve gastrectomy or Roux-en-Y gastric bypass procedures in the United States.To study the presence of the Hispanic paradox in metabolic and bariatric surgery utilizing the MBSAQIP registry.Academic Teaching Institution.Participant User Files from the Metabolic Bariatric Surgery Accreditation and Quality Improvement Program were reviewed for patients undergoing sleeve gastrectomy or Roux-en-Y gastric bypass (2015-2017). Patients were grouped by race (Hispanic versus all other races) and primary procedure performed. Variables for major and minor postoperative complications were combined. A univariate analysis was performed on unmatched and propensity-matched cohorts.After applying exclusions, 53,353 (13.7%) Hispanic patients and 335,299 non-Hispanic patients remained. A univariate analysis demonstrated Hispanic patients had the lowest preoperative co-morbidity profile compared with all other races and decreased rates of major and minor postoperative complications. Using matched-cohort data, when complications were assessed and grouped as major/minor complications, rates of major and minor complications in Hispanic patients were lower in the Roux-en-Y gastric bypass group, despite Hispanic patients having higher leak rates. Similarly, there were no differences between Hispanic/non-Hispanic sleeve gastrectomy patients in overall major/minor complication rates despite Hispanic patients exhibiting higher venous thromboembolism and lower bleeding compared with non-Hispanic patients.Hispanic patients undergo disproportionately low rates of metabolic and bariatric surgery procedures and present with lower incidence of preoperative co-morbidities. Additionally, Hispanic patients have the same or decreased incidence of postoperative complications compared with non-Hispanic patients, thereby corroborating the Hispanic paradox.
Published: 2020
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43. City-Scale Agent-Based Simulators for the Study of Non-pharmaceutical Interventions in the Context of the COVID-19 Epidemic

Author: Rajesh Sundaresan, Shubhada Agrawal, Narendra M. Dixit, Prahladh Harsha, Anand Deo, Piyush Srivastava, Sharad Shriram, Aditya Krishna Swamy, Nidhin Koshy Vaidhiyan, Siddharth Bhandari, Sandeep Juneja, Poonam Kesarwani, Preetam Patil, Nihesh Rathod, Sarath Yasodharan, Anirban Bhattacharjee, and Ramprasad Saptharishi
Subjects: 0301 basic medicine, 2019-20 coronavirus outbreak, Multidisciplinary, Knowledge management, Coronavirus disease 2019 (COVID-19), business.industry, Computer science, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Psychological intervention, Context (language use), Review Article, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Pandemic, 030212 general & internal medicine, City scale, business
Abstract: We highlight the usefulness of city-scale agent-based simulators in studying various non-pharmaceutical interventions to manage an evolving pandemic. We ground our studies in the context of the COVID-19 pandemic and demonstrate the power of the simulator via several exploratory case studies in two metropolises, Bengaluru and Mumbai. Such tools may in time become a common-place item in the tool kit of the administrative authorities of large cities.
Published: 2020
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44. Risk of chemotherapy-induced febrile neutropenia in patients with metastatic cancer not receiving granulocyte colony-stimulating factor prophylaxis in US clinical practice

Author: Gary H. Lyman, Mark Hatfield, Devi Sundaresan, Ahuva Averin, Manpreet Kaur, Amanda Silvia, Derek Weycker, Tatiana Lawrence, Kathryn Richert-Boe, Neel Shah, and Lois Lamerato
Subjects: Male, medicine.medical_specialty, Colorectal cancer, Febrile neutropenia, 03 medical and health sciences, Granulocyte colony-stimulating factor, 0302 clinical medicine, Breast cancer, Risk Factors, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, 030212 general & internal medicine, Risk factor, Chemotherapy-Induced Febrile Neutropenia, Lung cancer, Non-Hodgkin lymphoma, Aged, Retrospective Studies, business.industry, Incidence (epidemiology), Incidence, Cancer, Retrospective cohort study, Neoplasms, Second Primary, medicine.disease, United States, Oncology, 030220 oncology & carcinogenesis, Original Article, Female, business
Abstract: Objectives To evaluate the use of granulocyte colony-stimulating factor (G-CSF) prophylaxis in US patients with selected metastatic cancers and chemotherapy-induced febrile neutropenia (FN) incidence and associated outcomes among the subgroup who did not receive prophylaxis. Methods This retrospective cohort study was conducted at four US health systems and included adults with metastatic cancer (breast, colorectal, lung, non-Hodgkin lymphoma [NHL]) who received myelosuppressive chemotherapy (2009–2017). Patients were stratified by FN risk level based on risk factors and chemotherapy (low/unclassified risk, intermediate risk without any risk factors, intermediate risk with ≥ 1 risk factor [IR + 1], high risk [HR]). G-CSF use was evaluated among all patients stratified by FN risk, and FN/FN-related outcomes were evaluated among patients who did not receive first-cycle G-CSF prophylaxis. Results Among 1457 metastatic cancer patients, 20.5% and 28.1% were classified as HR and IR + 1, respectively. First-cycle G-CSF prophylaxis use was 48.5% among HR patients and 13.9% among IR + 1 patients. In the subgroup not receiving first-cycle G-CSF prophylaxis, FN incidence in cycle 1 was 7.8% for HR patients and 4.8% for IR + 1 patients; during the course, corresponding values were 16.9% and 15.9%. Most (> 90%) FN episodes required hospitalization, and mortality risk ranged from 7.1 to 26.9% across subgroups. Conclusion In this retrospective study, the majority of metastatic cancer chemotherapy patients for whom G-CSF prophylaxis is recommended did not receive it; FN incidence in this subgroup was notably high. Patients with elevated FN risk should be carefully identified and managed to ensure appropriate use of supportive care.
Published: 2020

45. A review of the barriers to using Patient‐Reported Outcomes (PROs) and Patient‐Reported Outcome Measures (PROMs) in routine cancer care

Author: Haryana M. Dhillon, Puma Sundaresan, Phyllis Butow, and Hanh Nguyen
Subjects: medicine.medical_specialty, barriers, Health Personnel, education, R895-920, MEDLINE, Review Article, CINAHL, 030218 nuclear medicine & medical imaging, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Surveys and Questionnaires, medicine, cancer, Humans, Radiology, Nuclear Medicine and imaging, Patient Reported Outcome Measures, patient‐reported outcome measures, Review Articles, Radiological and Ultrasound Technology, Health professionals, business.industry, Health condition, Outcome measures, Information technology, humanities, 030220 oncology & carcinogenesis, Family medicine, oncology, Patient-reported outcome, patient‐reported outcomes, business, Research setting
Abstract: Introduction Patient‐reported outcomes (PROs) are direct reports from patients about the status of their health condition without amendment or interpretation by others. Patient‐reported outcome measures (PROMs) are the tools used to measure PROs; they are usually validated questionnaires patients complete by self‐assessing their health status. Whilst the benefits of using PROs and PROMs to guide real‐time patient care are well established, they have not been adopted by many oncology institutions worldwide. This literature review aimed to examine the barriers associated with using PROs and PROMs in routine oncology care. Methods A literature search was conducted across EMBASE, Medline and CINAHL databases. Studies detailing barriers to routine PRO use for real‐time patient care were included; those focusing on PRO collection in the research setting were excluded. Results Of 1165 records captured, 14 studies informed this review. At the patient level, patient time, incapacity and difficulty using electronic devices to complete PROMs were prominent barriers. At the health professional level, major barriers included health professionals’ lack of time and knowledge to meaningfully interpret and integrate PRO data into their clinical practice and the inability for PRO data to be acted upon. Prominent barriers at the service level included difficulties integrating PROs and PROMs into clinical workflows and inadequate information technology (IT) infrastructures for easy PRO collection. Conclusion This review has outlined potential barriers to routine PRO use in the oncology setting. Such barriers should be considered when implementing PROs into routine clinical practice., Patient‐reported outcomes (PROs) are direct reports from patients about the status of their health condition without amendment or interpretation by others. This review article outlines potential barriers to routine PRO use in the oncology setting. Such barriers should be considered when implementing PROs into routine clinical practice.
Published: 2020
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46. S146—Jejunojejunal intussusception after roux-En-Y gastric bypass: a case series of 34 patients

Author: Keith S. Gersin, Kyle J. Thompson, Timothy S. Kuwada, Iain H. McKillop, Abdelrahman Nimeri, Naresh Sundaresan, Benedict Y Hui, and Lauren Poliakin
Subjects: Internal hernia, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.disease, Roux-en-Y anastomosis, Marginal Ulcer, Surgery, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Intussusception (medical disorder), Cholecystitis, Medicine, 030211 gastroenterology & hepatology, business, Laparoscopy, Complication, Abdominal surgery
Abstract: Jejunojejunal intussusception (JI) is a serious but rare complication that may occur following Roux-en-Y gastric bypass (RYGB) surgery. Causes of JI and best management strategy are not clearly defined. Electronic health records were queried for ICD 9/10 codes for intussusception after RYGB surgery (2009–2019), and charts retrospectively reviewed. Patient demographics, operative technique, presentation, radiology, and JI management were analyzed. Of the 2,327 RYGB patients identified at our institute, 34 (1.5%) were treated for JI. The mean age was 45.0 ± 8.6 years, mean BMI (RYGB surgery) was 43.1 ± 8.2 kg/m2, mean BMI at JI was 28.3 ± 5.8 kg/m2, and 30/34 were female, The mean time between RYGB and JI was 5.5 ± 4.3 years (range 1–17 years). Of the JI patients identified, 9 had operative notes that did not include jejunojejunostomy linear stapler length (JJ-LSL). Of the remaining 25 JI patients, 9 had a 60-mm JJ-LSL and 16 had a 120-mm JJ-LSL. Rate of intussusception was higher in the 120-mm versus 60-mm JJ-LSL group (p
Published: 2020
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47. From containment to harm reduction from SARS-CoV-2: a fabric mask for enhanced effectiveness, comfort, and compliance

Author: Sundaresan Jayaraman and Sungmee Park
Subjects: Harm reduction, medicine.medical_specialty, 2019-20 coronavirus outbreak, Polymers and Plastics, Coronavirus disease 2019 (COVID-19), business.industry, Materials Science (miscellaneous), Public health, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Industrial and Manufacturing Engineering, Compliance (psychology), Containment, Pandemic, medicine, General Agricultural and Biological Sciences, Intensive care medicine, business
Abstract: Although the COVID-19 pandemic shows no signs of abating, public health strategies have transitioned from containment to harm reduction. In light of this paradigm shift, it is critical that individ...
Published: 2020
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48. Ascidians

Author: Velusamy Arumugam, Manigandan Venkatesan, Karthik Ramachandran, Umamaheswari Sundaresan, and Saravanan Ramachandran
Subjects: Resource (biology), Natural resource economics, Business
Published: 2020
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49. Investigation of Bipolar Degradation of 1.2 kV BJTs under Different Current and Temperature Conditions

Author: Ranbir Singh, Nando Kaminski, Siddarth Sundaresan, and Sarah Rugen
Subjects: chemistry.chemical_compound, Materials science, chemistry, Mechanics of Materials, business.industry, Mechanical Engineering, Silicon carbide, Optoelectronics, Degradation (geology), General Materials Science, Current (fluid), Condensed Matter Physics, business
Abstract: Bipolar silicon carbide devices are attractive for high power applications offering high voltage devices with low on-state voltages due to plasma flooding. Unfortunately, these devices suffer from bipolar degradation, which causes a significant degradation of the on-state voltage. To explore the generation of stacking faults, which cause the degradation, the impact of the current density and temperature on bipolar degradation is investigated in this work. The analysis is done by stressing the base-collector diode of 1.2 kV bipolar junction transistors (BJTs) as well as the BJTs in common-emitter mode operation with different current densities at different temperatures.
Published: 2020
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50. Telehealth in Oncology During the COVID-19 Outbreak: Bringing the House Call Back Virtually

Author: Tilak Sundaresan, Christine B. Weldon, Tatjana Kolevska, Mary E. Reed, Julia R. Trosman, and Raymond W. Liu
Subjects: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Telehealth, Medical Oncology, Betacoronavirus, Neoplasms, House call, medicine, Humans, Viral therapy, Pandemics, SARS-CoV-2, Oncology (nursing), business.industry, Health Policy, COVID-19, Outbreak, Neoplasms therapy, medicine.disease, House Calls, Oncology, Medical emergency, Coronavirus Infections, business
Published: 2020
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