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This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain near-infrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development.

To determine if quantitative regional StO2 and HbT measured with near infrared spectroscopy (NIRS) could detect differences between normal neonates and those with acute cerebral injury or on cardiopulmonary bypass.

We present a method to noninvasively measure changes in pulsate cerebral blood flow (pCBF) and volume (pCBV) based on the shape of the heart beat pulse. We present preliminary data obtained from piglets.

We present measurements of the heartbeat obtained on human foreheads, using frequency domain and time domain systems. Preliminary results indicate that we are able to measure signals of the heartbeat originated from intracranial layers (brain).