1. Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study
- Author
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Mario Orlando Parra-Pineda, Aquiles Enrique Darghan, Silvia Alejandra Blanco Jaimes, Carmen Doris Garzón-Olivares, Jorge E. Caminos, Ariel Iván Ruiz-Parra, Estefania Pulido Sánchez, Luz Amparo Díaz-Cruz, Luis Miguel Maldonado Acosta, Natalia E. Poveda, María Fernanda Garcés, Elizabeth Sanchez, Héctor Fabio Sandoval Alzate, Alejandro Antonio Bautista-Charry, and Edith Angel Müller
- Subjects
medicine.medical_specialty ,Longitudinal study ,Article Subject ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,High-density lipoprotein ,Internal medicine ,medicine ,Pregnancy ,lcsh:RC648-665 ,Triglyceride ,Endocrine and Autonomic Systems ,Cholesterol ,business.industry ,nutritional and metabolic diseases ,Gestational age ,medicine.disease ,chemistry ,Cohort ,business ,Research Article - Abstract
Metabolic changes have been correlated with adverse pregnancy outcomes. The aim of the present study is to determine the TyG and TG/HDL-c indices in a cohort of healthy pregnant (n=142), preeclamptic (n=18), and healthy nonpregnant women (n=56). Preeclamptic women were selected from the same cohort. Pregnant women were followed during three periods of pregnancy and postpartum. The results showed a significant increase in the values of TyG and TG/HDL-c (p<0.01) as pregnancy progresses, without significant differences between healthy and preeclamptic women. TyG and TG/HDL-c indices are significantly low in nonpregnant and three months’ postpartum women when compared with each gestational period studied. TyG and TG/HDL-c indices are positively correlated with HOMA-IR in the early and middle pregnancy (p<0.05). Multiple linear regression using the TyG and TG/HDL-c indices as dependent variables showed that TyG index was significantly associated with HOMA-IR, gestational age, HDL-c, TC, LDL, fasting insulin, and mean BP (p<0.001); meanwhile, TG/HDL-c index was only associated with HOMA-IR (p<0.0242) and gestational age (p<0.001). In conclusion, the TyG and TG/HDL-c indices could be useful in monitoring insulin resistance during pregnancy.
- Published
- 2018