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Intrauterine adhesion (IUA) is a common endometrial disease and one of the main causes of infertility in women of childbearing age. Current treatment strategies, such as hysteroscopic adhesion resection, hysteroscopic transcervical resection of adhesion (TCRA), the use of local hormone drugs, and anti-adhesion scaffold implantation, do not provide a satisfactory pregnancy outcome for moderate-severe IUA, which presents a great challenge in reproductive medicine. With the development of material engineering, various bioactive and functional hydrogels have been developed using natural and synthetic biomaterials. These hydrogels are not only used as barely physical barriers but are also designed as vectors of hormone drugs, growth factors, and stem cells. These characteristics give bioactive hydrogels potentially important roles in the prevention and treatment of IUA. However, there is still no systematic review or consensus on the current advances and future research direction in this field. Herein, we review recent advances in bioactive hydrogels as physical anti-adhesion barriers, in situ drug delivery systems, and 3D cell delivery and culture systems for seeded cells in IUA treatment. In addition, current limitations and future perspectives are presented for further research guidance, which may provide a comprehensive understanding of the application of bioactive hydrogels in intrauterine adhesion treatment.

Background Family with sequence similarity 111 member B (FAM111B) is an oncoprotein associated with multiple malignancies. We investigated the potential mechanisms of FAM111B in breast cancer. Patients and Methods We tested the expression of FAM111B in breast cancer tissues and the survival rate of breast cancer patients with high or low level of FAM111B through TCGA data. The expression of FAM111B in breast cancer tissues and adjacent tissues was detected using western blotting. Then we used siRNA to construct a low expression model of FAM111B in SKBR3 and MDA-MB-468. EdU, CCK-8, wound healing, and transwell assays were performed to monitor the proliferation, migration, and invasion of breast cancer cells. Western blotting was used to detect the expression of EMT-related indicators. Chromatin Immunoprecipitation (ChIP) and qPCR were used to evaluate the regulatory effect of Yin Yang 1 (YY1) on FAM111B. Results The expression of FAM111B in breast cancer tissues was higher than that in normal tissues. Patients who had high FAM111B expression had a worse prognosis. Knockdown of FAM111B inhibited the proliferation, migration, and invasion of breast cancer cells. Knockdown of FAM111B resulted in increased expression of EMT-related protein E-cadherin and decreased expression of N-cadherin and Vimentin. ChIP-qPCR analysis demonstrated that YY1 could bind to the promoter of FAM111B gene and strengthen its transcription activity. Conclusion YY1-induced transcriptional activation of FAM111B accelerated the progression of breast cancer.

Some ship crew reported that there is deficiency of manning of engine department in The Three Gorges Reservoir Area which results in serious safety risks. To ensure the navigation safety and legal right of crew, it is of great necessity to re-evaluate the minimum safe manning standard of engine department in such area. By applying on board function model, the functions of engine department, which include sub-functions such as main engine operation, auxiliary equipment operation, general operation and daily management, are recognized. Based on statistics of questionnaires, the frequency of on board assignment, crew rank and time needed for completion of assignment are determined and based on which the number of manning of engine department are calculated with different levels. Then the manning standard of engine department in The Three Gorges Reservoir Area are obtained, such as ship with main engine power between 500kW and 1500kW and 10 hours or more continuous working time should be manned with one chief engineer, one second engineer, one third or fourth engineer and one oiler.

The composite insulation consisting of PTFE film layers with interstitial silicone gel, emerging as a new and dry alternative of high voltage insulation structure has been very successfully used for over 15 years in dry type capacitance- graded core insulation of high voltage equipments. This includes wall bushings, current transformers and cable terminals. This composite insulation structure is found in particular to have excellent partial discharge performance with the unique characteristic of self-attenuating when in operation, sometimes down to non-detectable levels. Numerous observations are described from early field-testing, laboratory testing and dissection analysis. The consistency of the phenomenon, even after 15 years of operation is confirmed. Simulation experiments were able to reproduce the characteristic and demonstrate that the level of voltage applied, the structure design and the presence of silicone gel govern the self-attenuation. This paper, after reviewing overall field performance, proposes a mechanism showing that the initial partial discharge helps to raise the breakdown voltage of the capacitor elements, thus reducing the onset of further discharges.

The composite insulation consisting of PTFE film layers with interstitial silicone gel, emerging as a new alternative type of insulation structure has been very successfully used for over 15 years in dry type capacitance-graded core insulation of high voltage equipments, such as wall bushings, current transformers and cable terminals. This composite insulation structure is found in particular to have excellent partial discharge performance with the unique characteristic of self-attenuating when in operation, sometimes down to non-detectable levels. Numerous observations are described from early field-testing, laboratory testing and dissection analysis. The consistency of the phenomenon, even after 15 years of operation is confirmed. Simulation experiments were able to reproduce the characteristic and demonstrate that the level of voltage applied, the structure design and the presence of silicone gel govern the self-attenuation. This paper then proposes a mechanism showing that the initial partial discharge helps to raise the breakdown voltage of the capacitor elements, thus reducing the onset of further discharges.