1. Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters
- Author
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Alan Hanley, Haroon Zafar, Martin J. Leahy, Faisal Sharif, Kate Dinneen, Ihsan Ullah, and Sajjad Matiullah
- Subjects
Coronary angiography ,Male ,functional-significance ,medicine.medical_specialty ,coronary stenosis ,education ,Frequency domain optical coherence tomography ,Coronary stenosis ,Fractional flow reserve ,Sensitivity and Specificity ,Severity of Illness Index ,in-vivo ,intravascular ultrasound ,Predictive Value of Tests ,Internal medicine ,Medicine ,Humans ,angiography ,fractional flow reserve ,reproducibility ,intervention ,Aged ,minimal lumen area ,criteria ,business.industry ,Area under the curve ,Middle Aged ,medicine.disease ,frequency domain optical coherence tomography ,Coronary Vessels ,Confidence interval ,myocardial-infarction ,minimal lumen diameter ,Fractional Flow Reserve, Myocardial ,Stenosis ,artery stenoses ,Predictive value of tests ,Cardiology ,Female ,no-reflow ,business ,Cardiology and Cardiovascular Medicine ,Tomography, Optical Coherence - Abstract
ObjectivesThe main objective of this study is to determine the correlation between fractional flow reserve (FFR)- and frequency domain optical coherence tomography (FD-OCT)-measured lumen parameters, and to determine the diagnostic competence of FD-OCT concerning the identification of severe coronary stenosis.MethodsA total of 41 coronary stenoses in 30 patients were assessed consecutively by quantitative coronary angiography (QCA), FFR, and FD-OCT. Stenoses were labeled severe if FFR≤0.80. The minimal lumen area (MLA), minimal lumen diameter (MLD), and percent lumen area stenosis (%AS) were measured using FD-OCT.ResultsFFR was ≤0.80 in 10 stenoses (24.4%). A poor but significant correlation between FFR and FD-OCT-measured MLA (r2=0.4, p
- Published
- 2014