113 results on '"Sahin Coban"'
Search Results
2. Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice
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Patrick Lowe, Sahin Coban, David Tornai, Donna Catalano, Yeonhee Cho, and Gyongyi Szabo
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Male ,Alcohol Drinking ,Inflammasomes ,medicine.drug_class ,media_common.quotation_subject ,Caspase 1 ,030508 substance abuse ,Medicine (miscellaneous) ,Alcohol ,Alcohol use disorder ,Pharmacology ,Toxicology ,Heterocyclic Compounds, 4 or More Rings ,Article ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,NLR Family, Pyrin Domain-Containing 3 Protein ,para-Aminobenzoates ,medicine ,Animals ,Sulfones ,Furans ,Receptor ,Neuroinflammation ,media_common ,Sex Characteristics ,Sulfonamides ,business.industry ,Addiction ,Inflammasome ,Dipeptides ,Receptor antagonist ,medicine.disease ,Mice, Inbred C57BL ,Psychiatry and Mental health ,Indenes ,chemistry ,Female ,0305 other medical science ,business ,030217 neurology & neurosurgery ,Signal Transduction ,medicine.drug - Abstract
BACKGROUND Alcohol use disorder is a significant societal and medical burden that is associated with both organ pathology and addiction. Excessive alcohol use results in neuroinflammation characterized by activation of the inflammasome, a multiprotein complex, and IL-1β increase in the brain. Recent studies suggest that inflammation could contribute to alcohol addiction. Here, we targeted components of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome cascade, which senses and responds to immunologic stimuli, to determine whether NLRP3 inhibition modulates alcohol consumption. METHODS C57BL/6J male and female mice were provided a 2-bottle choice of alcohol at increasing concentrations (3, 6, 9, and 12%, 4 days each) or water, and some were treated with daily injections of an NLRP3 inhibitor (MCC950), a caspase-1 inhibitor (VX765), IL-1 receptor antagonist (IL-1ra; anakinra), or vehicle injection. RESULTS Treatment with VX765, MCC950, and IL-1ra significantly reduced alcohol consumption and preference in female mice (p
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- 2020
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3. Future Directions for Endoscopic Ultrasound
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Ömer Başar, Sahin Coban, and William R. Brugge
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Endoscopic ultrasound ,medicine.medical_specialty ,Heading (navigation) ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Endoscopic ultrasonography ,digestive system diseases ,03 medical and health sciences ,Cystic lesion ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,030211 gastroenterology & hepatology ,Radiology ,Elastography ,business - Abstract
Endoscopic ultrasound (EUS) plays an important role as a diagnostic and therapeutic modality in gastroenterology. New developments have emerged, especially in the last decade, and are being introduced to endoscopists. The ability to readily visualize and access organs in the gastrointestinal tract has allowed endoscopists to perform new interventional procedures. EUS procedures have taken the place of conventional approaches for the treatment of various gastrointestinal diseases, including pancreatic cystic lesions. This article focuses on the advances and future of diagnostic and therapeutic EUS.
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- 2017
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4. Tenofovir–best hope for treatment of chronic hepatitis B infection?
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Necati Örmeci, Rahmet Guner, İsmail Balik, Sahin Coban, Hakan Akinci, İlhami Yüksel, Aysun Yalci, Burak Özbaş, Ömer Başar, Çağdaş Kalkan, Abdülkadir Dökmeci, Hasan Özkan, and Osman Yüksel
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medicine.medical_specialty ,HBsAg ,business.industry ,Gastroenterology ,virus diseases ,Lamivudine ,Entecavir ,Hepatitis B ,medicine.disease ,digestive system diseases ,HBeAg ,Hepatocellular carcinoma ,Internal medicine ,medicine ,Adefovir ,Seroconversion ,business ,medicine.drug - Abstract
Background/aims To evaluate the effectiveness of tenofovir in patients with chronic hepatitis B infection in a real life setting. Materials and methods We performed a retrospective analysis of data from 164 patients with chronic hepatitis B who were treated with Tenofovir. Eighty-six patients (52.4%) were naive. Seventy-seven (46.9%) patients were previously treated with anti-viral drugs, including standard interferon (n=4), pegylated (PEG) interferon (n=14), standard interferon together with lamivudine (n=13), lamivudine alone (n=41), adefovir (n=2), lamivudine together with adefovir (n=1), and entecavir (n=2). Six patients (3.7%) had liver cirrhosis before treatment of tenofovir. Results The patients who have hepatitis B viral DNA>104 copy/mL with chronic hepatitis B infection were included in the treatment of Tenofovir. Average follow up time was 30.31±14.33 months. HBV DNA negativity and alanine aminotransferase (ALT) normalization were 86.5% and 71.3%, respectively, at the last visit. Hepatitis B e-Antigen (HBeAg) seroconversion occurred in 11 (19.6%) out of 164 patients. During the follow-up period, 4 (2.4%) patients developed liver cirrhosis and in 5 (3%) patients hepatocellular carcinoma (HCC) occurred out of 164 patients. HBsAg seroconversion occurred in one patient (0.6%). Conclusion Tenofovir can be used safely and successfully in those patients that were naive, experienced with immune modulators and/or antivirals, HBeAg-positive, and HBeAg-negative patients.
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- 2015
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5. The efficiency of endoclips in maintaining the gastrointestinal bleeding-related Dieulafoy’s lesion
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Yusuf Üstün, Fatih Karaahmet, Yusuf Coskun, Zahide Simsek, Serta Kilincalp, Elife Erarslan, İlhami Yüksel, Sahin Coban, Hakan Akinci, and Mevlut Hamamci
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Adult ,Male ,Torsion Abnormality ,medicine.medical_specialty ,Gastrointestinal bleeding ,medicine.medical_treatment ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Submucosa ,medicine ,Humans ,Aged ,medicine.diagnostic_test ,business.industry ,Hemostasis, Endoscopic ,Equipment Design ,General Medicine ,Emergency department ,Clipping (medicine) ,Middle Aged ,Dieulafoy's lesion ,Surgical Instruments ,medicine.disease ,Surgery ,Endoscopy ,Arterioles ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,Gastrointestinal Hemorrhage ,business ,Case series - Abstract
Dieulafoy’s lesion (DL) is a relatively uncommon medical condition characterized by a large tortuous arteriole in the submucosa of any part of gastrointestinal (GI) tract wall that bleeds via erosion likely caused in the submucosal surface by protrusion of the pulsatile arteriole. Compared with other endoscopic hemostatic techniques, clipping alone for DL is limited. The aim of the present case series study is to identify common clinical and endoscopic features, rates of occurrence, to review the outcome of endoscopic management of upper GI tract DL, and to illustrate the use and the efficiency of endoclips in maintaining the GI bleeding due to DL. This case series was conducted at Department of Gastroenterology, Diskapi Yildirim Beyazit Educational and Research Hospital. The patients who were admitted to the emergency department of Diskapi Yildirim Beyazit Educational and Research Hospital underwent gastrointestinal system (GIS) endoscopy between 2008 and 2013 and were assessed retrospectively. Five cases of GI bleeding related to DL were given endoscopic treatment with hemoclip application. Clinical data, endoscopic findings, and the effects of the therapy were evaluated. The median number of endoscopic hemoclips application in first endoscopy was 4 (2–9). Rebleeding developed in all patients who had hemoclips applied. Re-endoscopy was performed in three of these patients, which controlled the bleeding. Two patients were transferred to surgery. Combination of endoscopic injection and mechanical therapies seems a suitable method for maintaining upper GIS bleeding due to DL. Also, further studies are needed to better define the best endoscopic approach for the treatment of DL.
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- 2015
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6. Utility of M30, an apoptotic serum marker, in liver diseases
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Ömer Başar, Sahin Coban, Osman Yüksel, and Akif Altinbas
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Pathology ,medicine.medical_specialty ,Programmed cell death ,Necrosis ,Apoptosis ,Keratin 18 ,Cytokeratin ,Health Care Sciences and Services ,medicine ,Humans ,Apoptosis,M30 level,liver injury ,Sağlık Bilimleri ve Hizmetleri ,Caspase ,Liver injury ,Keratin-18 ,biology ,business.industry ,Liver Diseases ,General Medicine ,medicine.disease ,Peptide Fragments ,biology.protein ,GDF15 ,medicine.symptom ,business ,Biomarkers - Abstract
The aim of this paper is to evaluate the role of apoptosis in some common liver diseases, and the utility of M30, an apoptotic serum marker, in the diagnosis of the severity of underlying hepatic injury. As is widely known, apoptosis is programmed cell death, and its deregulation results in an uncontrolled inflammatory process leading to upregulation of liver fibrogenesis. Both extrinsic and intrinsic pathways are crucial in apoptosis, and caspase cleavage of cytokeratin proteins occurs in both. Therefore, the measurement of caspase- cleaved cytokeratin fragments could be a novel method to assess the intensity of apoptotic cell numbers in epithelial tissue damage. M30 levels were found to increase not only in acute liver disorders, but also in some chronic liver injuries. We tried to summarize the recent studies focused on the role of apoptotic processes in liver diseases, mainly those that investigated the use of M30 in determining the severity of, or in predicting, ongoing liver injury.
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- 2015
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7. Association Between Mannose Binding Lectin Level and Progression of Chronic Hepatitis B
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Sahin Coban, Zeynep Ginis, Baris Yilmaz, Yusuf Coskun, Aydın Çifçi, Elife Erarslan, Fuat Ekiz, and İlhami Yüksel
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Hepatitis B virus ,Innate immune system ,business.industry ,chemical and pharmacologic phenomena ,Hepatitis B ,bacterial infections and mycoses ,medicine.disease_cause ,medicine.disease ,Control subjects ,Chronic hepatitis ,Fibrosis ,Immunology ,medicine ,business ,Active hepatitis ,Mannan-binding lectin - Abstract
Background: Mannose binding lectin (MBL) is believed to be an important component of the innate immune response. MBL may be an important non-invasive predictor for progression of hepatitis B virus infection. In this study, we examined whether there is a relationship between MBL levels and progression of hepatitis B virus infection. Methods: In this cross-sectional study, fifty patients with chronic hepatitis B and 21healthy control subjects were included. They were classified into three groups: Active hepatitis B, inactive hepatitis B and healthy control groups. The association between MBL level with the stage of fibrosis and histological activity index (HAI) was found in patients with active chronic hepatitis B. Results: The mean ± SD of MBL level was as 2875.3 ± 2040.03 ng/ml in active HBV patients, 2463.9 ± 1915.4 ng / ml in inactive HBV patients, and 1865.04 ± 265.6 ng/ml in healthy controls (P: 0.344). MBL was not significantly correlated with HAI and the stage of fibrosis (r: -0.30, P: 0.876 and r: 0.077, P: 0.687, respectively). Conclusion: In our study, we could not find any significant association between MBL levels and progression of HBV infection; which is not in line with the hypothesis that MBL may be beneficial as a non-invasive predictor of the survival of patients with hepatitis B virus infection.
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- 2017
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8. M30 Does Not Predict the Severity of Hepatosteatosis, Whereas Adiponectin Level Declined With Increase of ALT and the Severity of Hepatic Steatosis
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Muyesser Sayki, Erman Cakal, Sedat Caner, Baris Yilmaz, Tuncay Delibasi, Akif Altinbas, Sahin Coban, and Fatih Büyükcam
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Microbiology (medical) ,medicine.medical_specialty ,Adiponectin ,business.industry ,Biochemistry (medical) ,Clinical Biochemistry ,Public Health, Environmental and Occupational Health ,nutritional and metabolic diseases ,Hematology ,medicine.disease ,Polycystic ovary ,Medical Laboratory Technology ,Endocrinology ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,Nonalcoholic fatty liver disease ,Vitamin D and neurology ,medicine ,Immunology and Allergy ,Alanine aminotransferase ,Steatosis ,business - Abstract
Background Nonalcoholic fatty liver disease (NAFLD) is an emerging problem all over the world. Because NAFLD and polycystic ovary syndrome (PCOS) are both closely related with insulin resistance, it would be necessary to determine the rate of presence of NAFLD in PCOS patients. So, this study aimed to investigate the utility of M30 in PCOS patients for the diagnosis of hepatic injury. Methods Eighty patients with PCOS were included in the study. Ultrasonographic examination for the presence of hepatic steatosis, M30 serum level for determining the severity of ongoing apoptotic cell death in liver, and BARD index for defining the hepatic injury were performed during the study. 25-OH vitamin D and adiponectin level in sera were studied using ELISA (Enzyme-Linked ImmunoSorbent Assay). Results M30 and vitamin D levels did not change significantly with the severity of hepatic steatosis. On the other hand, M30 levels showed a positive correlation with ALT and AST levels, and M30 level suddenly increased with the presence of hepatic steatosis from 159.7 to 170 U/l, however stabilized with the increasing severity of hepatic setatosis. Adiponectin levels decreased with the increasing severity of hepatic steatosis and significantly varied between ALT greater than 40 U/l and less than 40 U/l. Conclusions M30 level in serum increased with the appearance of hepatic steatosis and had a positive correlation with a noninvasive hepatic injury test, BARD (BMI, aspartate aminotransferase [AST]/alanine aminotransferase [ALT] ratio [AAR], diabetes mellitus [DM]) index. Adiponectin level decreased with the increasing ALT level and severity of hepatic steatosis.
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- 2014
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9. Radyasyon proktitinde argon plazma koagulasyon tedavisinin etkinliğiRadyasyon proktitinde argon plazma koagulasyon tedavisinin etkinliği
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Baris Yilmaz, Zahide Simsek, Bora Aktaş, Fuat Ekiz, Ömer Başar, Sahin Coban, Murat Deveci, Osman Yüksel, and Akif Altinbas
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business.industry ,Medicine ,General Medicine ,business ,Nuclear medicine - Published
- 2013
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10. APRI, the FIB-4 score, and Forn’s index have noninvasive diagnostic value for liver fibrosis in patients with chronic hepatitis B
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Gulfer Ozturk, Aynur Albayrak, Osman Yüksel, Fuat Ekiz, Sahin Coban, Erdem Akbal, Sevilay Sezer, Zeynep Ginis, Ferah Armutcu, Ömer Başar, and Fatma Ucar
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Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,FGF21 ,alpha-2-HS-Glycoprotein ,Biopsy ,Liver fibrosis ,Severity of Illness Index ,Gastroenterology ,Transforming Growth Factor beta1 ,Hepatitis B, Chronic ,Predictive Value of Tests ,Internal medicine ,Severity of illness ,Humans ,Medicine ,In patient ,Platelet ,Aspartate Aminotransferases ,Tissue Inhibitor of Metalloproteinase-1 ,Hepatology ,medicine.diagnostic_test ,Platelet Count ,business.industry ,Middle Aged ,Hepatitis B ,Prognosis ,medicine.disease ,Fibroblast Growth Factors ,Liver ,ROC Curve ,Area Under Curve ,Predictive value of tests ,Female ,business ,Biomarkers - Abstract
The aim of this study was to evaluate the potential use of serum transforming growth factor-β1 (TGF-β1), tissue inhibitor of metalloproteinase-1 (TIMP-1), fetuin-A, and fibroblast growth factor 21 (FGF21) in the detection of liver fibrosis in patients with chronic hepatitis B (CHB). The value of the noninvasive fibrosis models - that is, the aspartate aminotransferase to platelet ratio index (APRI), the fibrosis index based on the four factors (FIB-4) score, and Forn's index - was also examined.CHB patients who underwent liver biopsy for the evaluation of fibrosis were included in the study. A total of 73 patients were divided into two groups according to their METAVIR scores (F0-1, no/minimal fibrosis; F2-4, significant fibrosis). Serum levels of TGF-β1, TIMP-1, fetuin-A, and FGF21 were measured besides APRI, FIB-4, and Forn's scores. The area under the receiver operating characteristic curve was measured for each parameter, followed by calculation of sensitivity, specificity, and positive and negative predictive values.APRI, FIB-4, and Forn's index scores were significantly higher in patients with significant fibrosis (P0.05). There was no difference between no/minimal fibrosis and significant fibrosis groups in terms of serum levels of TGFβ-1, TIMP-1, fetuin-A, and FGF21 (P0.05). The areas under the receiver operating characteristic curve for TGF-β1, TIMP-1, fetuin-A, FGF21, APRI, FIB-4, and Forn's index were 0.445, 0.483, 0.436, 0.585, 0.662, 0.687, and 0.680, respectively.Our results suggest that serum TGF-β1, TIMP-1, fetuin-A, and FGF21 are not useful for the assessment of the extent of liver fibrosis in CHB in this patient group. However, APRI, FIB-4, and Forn's index have a better diagnostic value in patients with significant fibrosis than in those with no/minimal fibrosis.
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- 2013
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11. Non-invasive tests in prediction of liver fibrosis in chronic hepatitis B and comparison with post-antiviral treatment results
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Osman Yüksel, Yaşar Tuna, Akif Altinbas, Ömer Başar, Sahin Coban, Fuat Ekiz, Bora Aktaş, Zeynep Ginis, Namik Delibas, and Barış Yımaz
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Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Cirrhosis ,Biopsy, Fine-Needle ,Antiviral Agents ,Sensitivity and Specificity ,Severity of Illness Index ,Gastroenterology ,Hemoglobins ,Hepatitis B, Chronic ,Liver Function Tests ,Predictive Value of Tests ,Fibrosis ,Internal medicine ,medicine ,Humans ,Aspartate Aminotransferases ,Serum Albumin ,Ultrasonography, Interventional ,Hematologic Tests ,Hepatology ,medicine.diagnostic_test ,biology ,Receiver operating characteristic ,Platelet Count ,business.industry ,Alanine Transaminase ,gamma-Glutamyltransferase ,Middle Aged ,Hepatitis B ,medicine.disease ,Surgery ,Cross-Sectional Studies ,Liver ,ROC Curve ,Alanine transaminase ,Predictive value of tests ,Liver biopsy ,biology.protein ,Female ,business ,Liver function tests ,Biomarkers - Abstract
Summary Background and aim The aim of this study was to assess and compare the performance of a series of non-invasive tests to detect fibrosis in patients with chronic hepatitis B (CHB). Patients and methods Seventy-six patients with CHB, whose blood samples were collected and biopsies were done on the same day, were included in this study. Pre-treatment calculations of aspartate aminotransferase to platelet ratio index (APRI), Forn's index, FIB-4, S-index, Shanghai Liver Fibrosis Group's index (SLFG) and Hepascore® were done and relations with mild and advanced fibrosis and cirrhosis were assessed. Post-treatment values of APRI, Forn's index, FIB-4, S-index with oral antiviral agents were also investigated. Results APRI, S-index, SLFG, FIB-4, Forn's index and Hepascore® had 0.669, 0.669, 0.739, 0.741, 0.753, 0.780; retrospectively Area Under the Receiver Operating Characteristic Curve (AUROC) for significant fibrosis. APRI, Forn's index, S-index, FIB-4, SLFG, and Hepascore® had 0.681, 0.714, 0.715, 0.738, 0.747, 0.777 retrospectively AUROC for advanced fibrosis. APRI, SLFG, FIB-4, Forn's index, S-index, and Hepascore® had 0.741, 0.742, 0.768, 0.779, 0.792, 0.824 retrospectively AUROC for cirrhosis. APRI, Forn's index, FIB-4 and S-index were significantly lower in post-treatment group compared with pre-treatment group (P-values: Conclusion Hepascore® showed the best performance to predict significant fibrosis. Our study also suggests that the use of non-invasive test to predict fibrosis in patients with CHB may reduce the need for liver biopsy and may help to monitor the efficacy of treatment.
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- 2013
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12. Peritoneal mesothelioma: Contribution of computerized tomography and magnetic resonance imaging findings to differential diagnosis
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Niyazi Kemal Arda, Sahin Coban, Bora Aktaş, Nazan Ciledag, Elif Aktas, and Basak Gulpinar
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Omental cake ,Magnetic resonance imaging ,medicine.disease ,Ascites ,medicine ,Peritoneal mesothelioma ,Mesothelioma ,Thickening ,Radiology ,Differential diagnosis ,medicine.symptom ,business ,Tissue biopsy - Abstract
Objective: In this article we review radiologic findings of malignant peritoneal mesothelioma with our patient arschives. We also want to give some information and detersmine importance of radiologic findings about differential diagnosis of malignant peritoneal mesothelioma. Materials and methods: We scanned our patient archive of mesothelioma between 2008 and 2012 years. We acscepted 15 patients with peritoneal mesothelioma who had computerized tomography (CT) or magnetic resonance imaging (MRI) at their initial diagnosis. Results: We found peritoneal irregularity and nodular thickening in 11 patients (73.3%), diffuse peritoneal thicksening (omental cake) in 5 patients (33.3%), ascites in 9 patients (60%), extension of adjunct tissue and hepatic metastases in only one patient (6.6%). Conclusion: Malignant mesothelioma may be difficult to diagnose with only clinical findings. CT and MRI helpful to diagnose and show spread of disease but tissue biopsy is required for the definitive diagnosis.
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- 2013
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13. Adding Pineapple Juice to a Polyethylene Glycol-Based Bowel Cleansing Regime Improved the Quality of Colon Cleaning
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Zahide Simsek, Akif Altinbas, Muhemmet Fatih Uyar, Murat Deveci, Bora Aktaş, Ömer Başar, Sahin Coban, Yaşar Tuna, Osman Yüksel, Baris Yilmaz, and Fuat Ekiz
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Adult ,Male ,medicine.medical_specialty ,Turkey ,Colon ,Medicine (miscellaneous) ,Colonoscopy ,Polyethylene glycol ,Ananas ,Polyethylene Glycols ,Beverages ,Electrolytes ,Young Adult ,chemistry.chemical_compound ,Humans ,Medicine ,Bowel cleansing ,Therapeutic Irrigation ,Aged ,Aged, 80 and over ,Nutrition and Dietetics ,medicine.diagnostic_test ,business.industry ,Middle Aged ,NUTRITION&DIETETICS ,PINEAPPLE JUICE ,Surgery ,chemistry ,Fruit ,Female ,business - Abstract
Background/Aims: An unsuccessful colonoscopy procedure is often related to inadequate bowel cleansing. It is difficult for patients to finish the whole 4 liters of polyethylene glycol-electrolyte lavage (PEG-EL) because of its salty taste and the large quantity. Pineapple juice has been shown to be an effective agent in the dissolution of undigested food in the stomach. This study assessed the effectiveness of both 2 and 4 liters of PEG-EL in precolonoscopic bowel cleansing and the quality of colonoscopic cleaning by adding 1 liter of pineapple juice to a reduced-volume PEG-based regime. Methods: The patients were chosen from those undergoing a colonoscopic procedure. A total of 126 patients were randomized into 3 groups receiving 3 different PEG-EL (Golytely®) regimes, i.e. 4 liters of PEG-EL (group 1, n = 44), 2 liters of PEG-EL (group 2, n = 39) or 2 liters of PEG-EL with 1 liter of pineapple juice (Dimes® 100%; group 3, n = 43). Results: Both the 4- and 2-liter PEG-EL regimes resulted in similar bowel cleansing scores in all parts of the colonic segments. However, adding 1 liter of pineapple juice to the reduced-volume PEG-EL regime improved the quality of the cleansing on the right side of the colon and in the transverse colon. Adequate bowel cleansing was achieved in 68.1% of the patients in group 1, 63.9% in group 2 and 80% in group 3 (the lowest score in one of the segments). On the other hand, the tolerability of the regimes was similar in all 3 groups (p = 0.509). Conclusions: Reduced PEG-EL (2 rather than 4 liters) may be sufficient for precolonoscopic bowel cleansing in the Turkish population. Administration of pineapple juice in the reduced-dose preparation regime may improve the quality of the bowel cleaning.
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- 2013
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14. Lamivudine Treatment Failure Risks in Chronic Hepatitis B Patients with Low Viral Load
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Huseyin Ataseven, Suut Gokturk, Rahmet Guner, Sahin Coban, Halis Simsek, Ozlem Baykal, Orhan Kursat Poyrazoglu, Tugrul Purnak, Metin Kucukazman, Murat Taner Gulsen, Yaşar Tuna, Hayretdin Koklu, Seyfettin Köklü, Mehmet Ibis, Sezgin Etgul, Cetin Karaca, Gonca Tatar, Murat Biyik, Ömer Başar, Mehmet Demir, Baris Yilmaz, Osman Yüksel, Erhan Alkan, Nimet Oge Koklu, and Cem Kockar
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Antibodies, Viral ,medicine.disease_cause ,Antiviral Agents ,Severity of Illness Index ,Treatment failure ,Hepatitis B, Chronic ,Chronic hepatitis ,Risk Factors ,Internal medicine ,Drug Resistance, Viral ,Severity of illness ,medicine ,Humans ,In patient ,Hepatitis B e Antigens ,Treatment Failure ,Retrospective Studies ,Hepatitis B virus ,Hepatitis B Surface Antigens ,business.industry ,Gastroenterology ,Lamivudine ,Retrospective cohort study ,Middle Aged ,Viral Load ,Virology ,DNA, Viral ,Female ,business ,Viral load ,Follow-Up Studies ,medicine.drug - Abstract
Aim: To analyze the risk factors of lamivudine treatment failure (LTF) for the long-term use in patients with low viral load (LVL). Material and Methods: In this multicenter study, 548 antiviral naïve noncirrhotic adult patients with LVL (for HBeAg+ patients HBV DNA 9 copies/ml and for HBeAg- patients HBV DNA 7 copies/ml) were enrolled. As a control group, 46 lamivudine-initiated patients with high viral load (HVL) were included. Primary outcome was switching to or adding on another antiviral drug as a consequence of primary nonresponse, partial response, viral breakthrough or adverse events. Secondary outcomes included LTF rates at 1, 2, 3, 4 and 5 years and LTF-related viral and host factors. Results: Among 594 patients, 294 had to change lamivudine at the follow-up. Primary nonresponse, partial response, viral breakthrough or adverse events frequencies were 6.8, 1.6, 64.5 and 0.1%, respectively. Five-year LTF rates were 61.3 and 84.2% in patients with LVL and HVL, respectively. Among patients with LVL, patients with Conclusion: Similar to patients with HVL, first-line lamivudine therapy is not efficient for long-term use in patients with LVL. LTF risk is so high even in the absence of worse predictive factors.
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- 2013
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15. The Role of M30 in Predicting the Severity of Liver Fibrosis and Inflammation in Chronic Hepatitis B Patients
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Serta Kilincalp, Fuat Ekiz, Bora Aktaş, Ömer Başar, Zahide Simsek, Murat Deveci, Sahin Coban, Gulfer Ozturk, Zeynep Ginis, Osman Yüksel, Akif Altinbas, and Baris Yilmaz
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medicine.medical_specialty ,Pathology ,Liver fibrosis ,Inflammation ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Chronic hepatitis ,Internal medicine ,Medicine ,Chronic viral hepatitis B ,Hepatology ,medicine.diagnostic_test ,business.industry ,M30 ,Kowsar ,Infectious Diseases ,Apoptosis ,030220 oncology & carcinogenesis ,Liver biopsy ,Liver Fibrosis ,030211 gastroenterology & hepatology ,Chronic Hepatitis B ,medicine.symptom ,business ,Research Article ,Serum markers - Abstract
Background Liver biopsy is an invasive procedure that is currently still necessary for predicting underlying hepatic injury related to chronic viral hepatitis B (CVHB). To date, none of the studied non-invasive methods have been able to replace liver biopsy. An apoptotic serum marker, M30, which has been reported to indicate ongoing liver fibrosis, has been popular in recent years. Objectives We aimed to investigate the possible role of M30 in predicting CVHB-associated hepatic injury and its severity. Methods Forty-eight patients undergoing liver biopsy for evaluation of the severity of CVHB-related liver injury and 40 healthy controls were included in this cross-sectional study. M30 levels were determined for all CVHB patients and controls, and other laboratory parameters and demographic features were obtained from our hospital’s database. Results The mean ages of patients and controls were 39.7 and 45.7 years, respectively, and 35% of the controls and 52% of the patients were male. In contrast to lower platelet counts, transaminase and M30 levels were both higher in the patient group than in the controls. Among the investigated parameters, only transaminase increased as the fibrosis stage changed from mild to moderate; however, none of the laboratory parameters, including M30, differed as the histological activity index (HAI) score increased. Conclusions M30 levels were higher in CVHB patients compared to healthy controls. However, M30 levels were similar in the mild and moderate stages of fibrosis, so they did not indicate the severity of underlying fibrotic or inflammatory processes in CVHB patients.
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- 2016
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16. Albumin Infusion is not Beneficial in Hypoalbuminemic End-Stage Cancer Patients: A Matched-Pair Analysis
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Yildirim Beyazit, Fikri Icli, Bulent Yalcin, Abdullah Büyükçelik, Sahin Coban, Ahmet Demirkazik, Halil Kavgaci, Mutlu Dogan, and Acibadem University Dspace
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Terminally ill cancer patient ,Matched Pair Analysis ,medicine.medical_specialty ,business.industry ,Albumin ,Terminally ill ,Cancer ,Retrospective cohort study ,Hematology ,medicine.disease ,Gastroenterology ,Surgery ,Blood pressure ,Oncology ,Internal medicine ,Medicine ,In patient ,Albumin infusion ,business ,Hypoalbuminemia ,End stage cancer - Abstract
In this retrospective study, it was aimed whether albumin infusion is benefical or not in terminally ill hospitalized hypoalbuminemic cancer patients. Between March 2000 and 31 March 2003, the medical records of 27 terminally ill hypoalbuminemic cancer patients who had albumin infusion(Albumin receiving group-ARG), were retrospectively analysed. This grup was matched (1:1) with 27 ter- minally ill cancer patients who had no albumin infusion (Albumin not receiving group-ANRG), according to age, sex, ECOG PS, diag- nosis and the number of metastatic sites. ARG was compared with ANRG, in regard to the changes of pulse rate, blood pressure, in the levels of serum BUN, creatinin, sodium, total protein, and albumin before albumin infusion and 48 hours after albumin infusion, and documented and/or clinical infections after albumin infusion, hospitalization duration, the rate of exitus in hospital and overall sur- vival. There was no difference in patient characteristics between two groups. Likewise, the groups were not different from each other in terms of the changes of puls rate, blood pressure, in the levels of serum BUN, creatinin, sodium, and documented and/or clinical infections after albumin infusion (p> 0.05). There was a significant increase in the levels of serum total protein and albumin in ARG (p< 0.05). The rate of exitus in hospital is not different between two groups. The median duration of hospitalization was longer in ANRG (p= 0.022). The overall survival was significantly better in ANRG (p= 0.018). Albumin infusion is not benefical in terminally ill hypoalbuminemic cancer patients. Furthermore, it was found that the survival was significantly worse in patients receiving albumin.
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- 2012
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17. Evaluation of Barrett's esophagus with CK7, CK20, p53, Ki67, and COX2 expressions using chromoendoscopical examination
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Necati Örmeci, Berna Savaş, Sahin Coban, Fuat Ekiz, Isinsu Kuzu, Murat Palabıyıkoğlu, and Arzu Ensari
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medicine.medical_specialty ,Pathology ,medicine.diagnostic_test ,business.industry ,Crypt Epithelium ,Gastroenterology ,Intestinal metaplasia ,General Medicine ,medicine.disease ,digestive system ,digestive system diseases ,Chromoendoscopy ,medicine.anatomical_structure ,Barrett's esophagus ,Internal medicine ,Metaplasia ,Biopsy ,Carcinoma ,medicine ,Esophagus ,medicine.symptom ,business - Abstract
SUMMARY Barrett's esophagus (BE) is a complication of chronic gastroesophageal reflux disease and can be diagnosed when there is an endoscopically irregular Z-line and intestinal metaplasia (IM) in a biopsy obtained lower esophagus. It is still not clear whether IM in the gastric cardia or columnar mucosa without IM in the lower esophagus have any significance as BE, which is considered as preneoplastic. The aim of the study was to determine the immunohistochemical features of BE and columnar mucosa in the distal esophagus and also to evaluate the value of chromoendoscopy in the diagnosis of BE in a prospective manner. A total of 12 chromoendoscopic biopsies (six from normal-looking unstained esophagus and six from esophageal mucosa stained with methyl blue suspicious of BE) were taken from 111 cases who underwent endoscopy because of a variety of upper gastrointestinal symptoms. Immunohistochemical analysis was performed using CK7, CK20, p53, Ki67, and cyclooxygenase 2 (COX2). Of the 111 cases, 19 cases with carcinoma (nine adeno, six squamous, four undifferentiated carcinomas) and 17 cases with normal squamous epithelium were excluded, while 75 cases showing columnar epithelium, including 46 (61.3%) with IM and 29 (38,7%) without IM, were further evaluated immunohistochemically. CK7 was observed in surface, crypt, and glandular epithelium, whereas CK20 was expressed in surface and superficial crypt epithelium. No significant difference was observed between the Barrett and non-Barrett type of CK7/20 staining pattern (P > 0,05). Expression of p53 did not show any difference between BE and columnar mucosa without IM, whereas COX2 expression was significantly increased in BE (P < 0.05) in comparison with columnar mucosa without IM. Ki67 expression was significiantly higher both in upper and lower crypts in BE (P < 0.05). The present study showed that a Barrett pattern does not seem to exist; however, the analysis of COX2 expression and the Ki67 proliferation fraction by immunohistochemistry can be used to separate BE from non-Barrett's metaplasia of the distal esophagus. In our point of view, the immunohistochemical detection of p53 expression in Barrett's metaplasia stage is useless as a marker for early detection of high-risk patients.
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- 2012
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18. Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection?
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Akif Altinbas, Sahin Coban, Bora Aktaş, Bariş Yilmaz, Osman Yüksel, Ömer Başar, and Fuat Ekiz
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Adult ,Male ,Hepatitis B virus ,HBsAg ,medicine.medical_specialty ,Guanine ,Time Factors ,Organophosphonates ,Specialties of internal medicine ,Drug resistance ,Antiviral Agents ,Gastroenterology ,Hepatitis B, Chronic ,Predictive Value of Tests ,Internal medicine ,Drug Resistance, Viral ,medicine ,Humans ,Anti-viral medication ,Tenofovir ,Aged ,Chronic HBV infection ,Hepatitis B Surface Antigens ,Hepatology ,business.industry ,Adenine ,virus diseases ,General Medicine ,Middle Aged ,Hepatitis B ,medicine.disease ,Response to treatment ,digestive system diseases ,Titer ,Treatment Outcome ,Qualitative HBsAg titer ,RC581-951 ,Lamivudine ,Predictive value of tests ,Virologic response ,DNA, Viral ,Immunology ,Quantitative hbsag ,Female ,Interferons ,business ,Biomarkers ,Follow-Up Studies - Abstract
Background. In the follow up of chronic hepatitis B infection (HBV), a significant correlation between quantitative HBsAg titer measurement and HBV DNA level, and moreover with intrahepatic covalently closed circular DNA was already shown. However, besides their impact on long-term follow up, they are really expensive methods, and not available widespread. We aimed to investigate the utility of qualitative measurement of HBsAg titer in prediction of virologic response at the end of the first year of anti-viral treatment in chronic HBV infection.Material and methods. A total of 70 patients receiving anti-viral therapies for chronic HBV infection were included into the study. The patients were evaluated according to Hbe Ag status and response to treatment. The determinations used in the study (biochemical, virologic responses, primary non-response) were accepted as it was described in AASLD.Results. Qualitative HBsAg titer increased significantly in both HBeAg positive and negative patients (p values 0.002 and < 0.000). Increasing of HBsAg titer in first three months is more dramatic in responder group, however the difference was disappeared at the sixth and twelve moths on follow up. Similarly, a fast increasing in anti-HBe titer in HBeAg negative chronic HBV patients was related with higher response at the end of first year therapy. However, the changings at the 12th month of anti-viral treatment were similar in both responder and non-responder groups.Conclusion. In conclusion, the fast increase in qualitative measurement of HBsAg titer seemed to be a predictor of higher anti-viral medication success in chronic HBV patients. However, this meaningful increasing was disappeared on the follow up, particularly after the six months examination.
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- 2012
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19. Mean Platelet Volume in the Diagnosis and Prognosis of Crimean–Congo Hemorrhagic Fever
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Akif Altinbas, Sahin Coban, Özlem Ekiz, Fuat Ekiz, Bora Aktaş, Irfan Sencan, Gönül Çiçek Şentürk, Gökhan Aytekin, Baris Yilmaz, Yunus Gürbüz, and Ömer Başar
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Male ,Tajikistan ,Crimean–Congo hemorrhagic fever ,medicine.medical_specialty ,Gastroenterology ,Internal medicine ,medicine ,Humans ,Mean platelet volume ,Retrospective Studies ,business.industry ,Zoonosis ,Case-control study ,Retrospective cohort study ,Hematology ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Blood coagulation factors ,Surgery ,ROC Curve ,Case-Control Studies ,Hemostasis ,Hemorrhagic Fever Virus, Crimean-Congo ,Female ,Hemorrhagic Fever, Crimean ,business ,Mean Platelet Volume - Abstract
Introduction: Crimean–Congo hemorrhagic fever (CCHF) is a viral tick-borne zoonosis, which is a severe illness, causing hemorrhages in humans. Mean platelet volume (MPV) is used as a surrogate marker of platelet function and has been shown to be a sign of inflammation. The objective of the present study is to examine the association between MPV and CCHF. We also aimed to investigate the association between MPV and coagulopathy markers in the mortality rates and prognosis of patients with CCHF. Patients and Methods: Ninety-three patients with CCHF were enrolled retrospectively into the study and 15 of them were excluded according to the exclusion criteria. Twenty-five healthy individuals were included as a control group which was age and gender matched with CCHF patients. We compared the levels of MPV between the patient and the control groups. We also compared the coagulopathy markers of fatal CCHF patients (n = 9) with nonfatal cases (n = 69). Results: Platelet counts were significantly lower in the CCHF group. Levels of international normalized ratio (INR), prothrombin time (PT), and activated partial thromboplastin time (aPTT) were significantly higher in CCHF group ( P < .001, Conclusion: In conclusion, MPV may be a beneficial marker in the diagnosis of CCHF, especially in cases with thrombocytopenia, the MPV levels are high. We also conclude that MPV may independently predict the prognosis of patients with CCHF.
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- 2012
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20. The effect of age and Helicobacter pylori infection on gastric epithelial cell kinetics
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Hakan Akbulut, Arzu Ensari, Murat Törüner, Teslime Atli, Sahin Coban, and Irfan Soykan
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Proliferative index ,Gastroenterology ,Helicobacter Infections ,Young Adult ,Internal medicine ,Biopsy ,medicine ,Pi ,Humans ,Risk factor ,Antrum ,Aged ,Cell Proliferation ,Aged, 80 and over ,Helicobacter pylori ,Hepatology ,medicine.diagnostic_test ,business.industry ,Age Factors ,Cancer ,Epithelial Cells ,Histology ,Middle Aged ,medicine.disease ,Epithelium ,medicine.anatomical_structure ,Gastric Mucosa ,Female ,business - Abstract
Summary Background Helicobacter pylori infection is a known risk factor for gastric cancer. The aim of the study was to determine the effect of H. pylori and age on gastric epithelial cell kinetics. Methods One hundred and fifty-seven patients (92 men, median age: 58.5 years, range: 18–85) who had undergone upper gastrointestinal endoscopy due to dyspeptic symptoms were enrolled into the study. Six antral biopsy samples were obtained for flow cytometric DNA analysis (expressed as proliferative index [PI], S+G2/M phase), presence of H. pylori (CLO-test, culture and histology), and histopathologic examination. Results Eighty-four (53.5%) patients were H. pylori positive and 93.3% of patients had diploid pattern and 6.7% expressed aneuploid pattern. The mean PI was 4.8 ± 0.2 for the whole group studied. PI were 5.14 ± 0.33 and 4.26 ± 0.36 for H. pylori (+) and H. pylori (−) patients respectively ( P = 0.017). When age groups were taken into account, PI was found higher in patients over 75 years of age ( n = 14, PI = 6.66 ± 1.3) compared to patients under 35 years of age ( n = 25, PI = 3.83 ± 0.41, P = 0.014). There was no correlation between histological changes and PI. H. pylori ( P = 0.045) and age ( P = 0.082) were independent factors for PI. Conclusion PI of gastric antral mucosa increases in patients with H. pylori infection. Although PI increases by age, H. pylori is the only factor that significantly and independently influences the rate of epithelial cell proliferation.
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- 2011
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21. Gamma-Glutamyltranspeptidase in Predicting Sustained Virological Response in Individuals with Chronic Hepatitis C
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Ali Tüzün, Sahin Coban, Ramazan Idilman, and Esra Erden
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Adult ,Male ,medicine.medical_specialty ,Combination therapy ,Interferon alpha-2 ,Single Center ,Antiviral Agents ,Gastroenterology ,Polyethylene Glycols ,chemistry.chemical_compound ,Pegylated interferon ,Internal medicine ,Diabetes mellitus ,Ribavirin ,Humans ,Medicine ,Aged ,Hepatology ,biology ,business.industry ,Interferon-alpha ,virus diseases ,gamma-Glutamyltransferase ,General Medicine ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,Recombinant Proteins ,digestive system diseases ,chemistry ,Alanine transaminase ,Multivariate Analysis ,biology.protein ,Drug Therapy, Combination ,Female ,business ,Viral load ,Body mass index ,medicine.drug - Abstract
BACKGROUND/AIMS Serum gamma-glutamyltranspeptidase (GGT) levels often increase in chronic hepatitis C. We aimed to identify whether GGT levels can predict sustained virological response (SVR) in patients with chronic hepatitis C and to investigate other potential predictive factors associated with SVR in patients with chronic hepatitis C treated with pegylated interferon and ribavirin at a single center. METHODOLOGY We evaluated 112 consecutive patients with histologically proven chronic hepatitis C who were treated with pegylated interferon and ribavirin. As potential predictors of SVR to combination therapy, we analyzed age, gender, body mass index, pretreatment GGT and alanine transaminase levels, diabetes mellitus, receiving of anti-viral therapy before beginning combination therapy, viral load, and liver histology by use of a multivariate logistic regression model. RESULTS SVR to combination therapy was seen in 57.2% of the patients. Variables associated with lower rates of sustained response were liver steatosis (p=0.026), diabetes mellitus (p=0.027), receiving anti-viral therapy before beginning combination therapy (p=0.016), higher GGT levels before therapy (>50IU/mL, p
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- 2011
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22. Carcinoid Tumor of the Minor Duodenal Papilla: A Rare Entity in Elderly Individuals
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Ata Turker Arikok, Osman Yüksel, Sahin Coban, Bora Aktaş, Zahide Simsek, and Ömer Başar
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medicine.medical_specialty ,business.industry ,Internal medicine ,Minor duodenal papilla ,Rare entity ,Medicine ,Geriatrics and Gerontology ,business ,Gastroenterology - Published
- 2014
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23. Thrombosis of the Portal Venous System
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Sahin Coban, Bülent Ödemiş, Nurgül Şaşmaz, Engin Uçar, Seyfettin Köklü, Mehmet Arhan, Osman Yüksel, İbrahim Ertuğrul, Mehmet Ibis, and Ömer Başar
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Adult ,Male ,medicine.medical_specialty ,Gastrointestinal bleeding ,Abdominal pain ,Portal venous system ,Hypertension, Portal ,medicine ,Humans ,Prospective Studies ,Aged ,Portal Vein ,business.industry ,Vascular disease ,Gastroenterology ,Thrombosis ,Middle Aged ,Prognosis ,medicine.disease ,Abdominal Pain ,Portal vein thrombosis ,Surgery ,Splenic Vein ,Splenic vein ,Portal hypertension ,Female ,Radiology ,medicine.symptom ,Gastrointestinal Hemorrhage ,business - Abstract
Background: Thrombosis in the portal system causes a wide spectrum of clinical pictures. There are few published studies describing the clinical features and consequences of portal venous system thrombosis. We aimed to document presentations and outcomes in patients with thrombosis in the portal and/or splenic veins. Patients and Methods: The study included 95 patients who were diagnosed with portal venous system thrombosis in the period September 2001 to April 2006. Demographics, clinical presentation, diagnostic investigation, management, morbidity, and mortality were recorded in their follow-up. Results: Of the 95 patients with portal vein thrombosis (PVT), 35 had isolated PVT (IPVT), 27 had isolated splenic vein thrombosis (ISVT), and 33 had thrombosis in both the portal and splenic veins (PSVT). The mean follow-up periods after diagnosis of IPVT, ISVT, and PSVT were 36, 31, and 32 months, respectively. Abdominal pain and gastrointestinal bleeding were the most common symptoms at presentation in the IPVT and PSVT groups, whereas abdominal pain was the dominant symptom in the ISVT group. During the follow-up period, no bleeding was seen in 26 of the 35 (74%) patients with IPVT, in 23 of the 33 (70%) patients with PSVT, and in 24 of the 27 (89%) patients with ISVT. Biliopathy developed during follow-up in 11 of 35 patients with IPVT, in 1 of 27 with ISVT, and in 5 of 33 with PSVT. In the ISVT group, there were 11 deaths, and one each in the IPVT and PSVT groups. Conclusions: The etiology of PVT varies in portal and splenic veins. IPVT has a higher morbidity (bleeding and portal biliopathy), whereas ISVT that is not associated with an underlying malignancy has a favorable prognosis.
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- 2008
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24. A Tale of Two Cities
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Necati Örmeci, V.A. Botoman, Sahin Coban, Arzu Ensari, Woodhouse S, Palabykoglu M, and Gregory F. Bonner
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Adult ,Diarrhea ,Male ,medicine.medical_specialty ,Malabsorption ,Adolescent ,Turkey ,Duodenum ,Anemia ,Turkish ,Biopsy ,Disease ,Coeliac disease ,Sprue ,Internal medicine ,Immunopathology ,medicine ,Humans ,Hypoalbuminemia ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Gastroenterology ,Middle Aged ,medicine.disease ,language.human_language ,Surgery ,Celiac Disease ,Chronic Disease ,Florida ,language ,Female ,business - Abstract
Goal: Recent studies suggest an increasing prevalence of atypical initial symptoms in patients with celiac disease (CD). The aim of this study was to compare the presenting symptoms of CD at 2 comparable referral institutions in South Florida, and in Ankara, Turkey. We retrospectively reviewed the records of patients with an initial diagnosis of CD by small bowel biopsy during the same (1991 to 2001) 10-year period at Cleveland Clinic Florida and University of Ankara, Turkey. A numerical score was assigned to presenting symptom and signs. Results: There were 28 patients in the South Florida group (51% men) and 40 patients in the Turkish group (35% men) (P = NS). The Turkish patients were significantly younger at diagnosis (36 ± 2y vs. US patients 66 ± 3y) (P
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- 2008
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25. The usefulness of chromoendoscopy with methylene blue in Barrett’s metaplasia and early esophageal carcinoma
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Isinsu Kuzu, Berna Savaş, Necati Örmeci, Murat Palabıyıkoğlu, Nazmiye Kurşun, Sahin Coban, and Arzu Ensari
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Esophageal Neoplasms ,Risk Assessment ,Sensitivity and Specificity ,Gastroenterology ,Chromoendoscopy ,Cohort Studies ,Diagnosis, Differential ,Barrett Esophagus ,Internal medicine ,Metaplasia ,medicine ,Humans ,Esophagus ,Aged ,Aged, 80 and over ,Staining and Labeling ,Esophageal disease ,business.industry ,Biopsy, Needle ,Intestinal metaplasia ,Middle Aged ,medicine.disease ,Immunohistochemistry ,digestive system diseases ,Methylene Blue ,medicine.anatomical_structure ,Dysplasia ,Barrett's esophagus ,Carcinoma, Squamous Cell ,Adenocarcinoma ,Female ,Surgery ,Esophagoscopy ,medicine.symptom ,business ,Precancerous Conditions ,Follow-Up Studies - Abstract
Barrett's esophagus is a condition that is premalignant for adenocarcinoma of the esophagus and the esophagogastric junction. Early detection of Barrett's metaplasia and dysplasia is very important to decrease the mortality and morbidity from esophageal adenocarcinoma cancer. This study aimed to evaluate the effectiveness of methylene blue-targeted biopsies in the differential diagnosis of intestinal metaplasia, dysplasia, and superficial esophageal carcinoma.A total of 109 patients (43 women and 66 men; average age, 62.32 +/- 10.61 years; range, 33-82 years) were enrolled for the study. Four groups were designed before endoscopic examinations. The patients for these groups were selected at the conventional endoscopy, and then chromoendoscopy was performed. The esophagus was stained with methylene blue, after which six biopsies were taken from stained and unstained areas.Conventional and chromoendoscopic assessments were compared with histopathologic examination. The sensitivity of chromoendoscopy for Barrett's epithelium was superior to that of conventional endoscopy (p0.05). However, there was no statistical difference between the two methods in the diagnosis of esophagitis or esophageal carcinoma (p0.05). Stained biopsies were superior to unstained biopsies in terms of sensitivity for Barrett's epithelium and esophageal carcinoma (p0.001).Chromoendoscopy is useful for delineating Barrett's epithelium and for indicating the correct location for securing biopsies where dysplasia or early esophageal cancer is suspected.
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- 2007
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26. What is the main target: a clearer colon with a sennoside-based regime, or adequate bowel cleansing before colonoscopy with a PEG-EL-based regime?
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Bora Aktaş, Akif Altinbas, Baris Yilmaz, Sahin Coban, Zahide Simsek, Osman Yüksel, Ömer Başar, and Fuat Ekiz
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Adult ,Male ,medicine.medical_specialty ,Sennosides ,Colonoscopy ,Gastroenterology ,Polyethylene Glycols ,Colonic Diseases ,Electrolytes ,Internal medicine ,Medicine ,Humans ,Bowel cleansing ,Therapeutic Irrigation ,medicine.diagnostic_test ,business.industry ,Cathartics ,Senna Extract ,Reproducibility of Results ,Mean age ,General Medicine ,Surgery ,Pharmaceutical Solutions ,Treatment Outcome ,Precolonoscopic bowel cleansing,polyethylene glycol regime,X-M solution ,Female ,business - Abstract
Background/aim: Even though polyethylene glycol-electrolyte lavage (PEG-EL)-based regimes have become the gold standard in recent years, to finish drinking 4 L of PEG-EL solution can be difficult. The quality of sennoside-based bowel-cleansing regimes used in Turkey has been known for some time. Therefore, we aimed to investigate the efficacy of both bowel-cleansing regimes. Materials and methods: Patients over 18 years old undergoing elective colonoscopic procedures between January and March 2011 were included in the study. The patients were divided into 2 groups; in Group 1, 91 patients were given sennoside a + b calcium 500 mg/250 mL (X-M solution, Yenişehir Laboratuarı, Ankara, Turkey), and in Group 2, 94 patients were given 4 L of PEG-EL (Golytely, Boston, MA, USA). Results: The mean age of the patients and the male distribution were similar in the 2 groups. Both inadequate bowel cleansing and the best cleansed bowels were seen in Group 1. The number of inadequate colonoscopies declined when using a whole bowel-cleansing regime from 24.5% to 19.3% in Group 2, but it did not decline in Group 1. Conclusion: The best bowel cleansing can be achieved with sennoside-based regimes, whereas a greater proportion of adequate results via colonoscopy were reached with the PEG-EL-based regimes.
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- 2015
27. Impact of endogenous activity of oestrogen in patient with hepatitis B virus infection
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Fatih Karaahmet, Sahin Coban, and İlhami Yüksel
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Hepatitis B virus ,Male ,Hepatology ,business.industry ,Interleukin-6 ,Endogeny ,Estrogens ,medicine.disease_cause ,Hepatitis B ,Prognosis ,Virology ,Text mining ,Immunology ,medicine ,Humans ,In patient ,Female ,business - Published
- 2015
28. Double-balloon enteroscopy for the detection of diffuse small-bowel polypoid ganglioneuromatosis mimicking Crohn's disease in a patient with von Recklinghausen disease
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Sahin Coban, İlhami Yüksel, Serta Kilincalp, Hakan Akinci, Mevlut Hamamci, and Aydın Şeref Köksal
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Enteroscopy ,medicine.medical_specialty ,Gastrointestinal bleeding ,Pathology ,Abdominal pain ,Neurofibromatosis 1 ,Colonoscopy ,Ileum ,Multiple Endocrine Neoplasia Type 2b ,Digestive System Neoplasms ,Gastroenterology ,Diagnosis, Differential ,Crohn Disease ,Double-balloon enteroscopy ,Internal medicine ,medicine ,Humans ,Double-Balloon Enteroscopy ,Crohn's disease ,medicine.diagnostic_test ,business.industry ,Ganglioneuroma ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Jejunum ,Female ,medicine.symptom ,business ,Ganglioneuromatosis - Abstract
A 51-year-old woman with an 8-month history of recurrent episodes of abdominal pain, mild bloody diarrhea, andweight loss (6kg in 3 months) was referred to our unit for evaluation of suspected Crohn’s disease. She had carried a diagnosis of type 1 neurofibromatosis for 30 years. Physical examination revealed multiple cafe-au-lait spots and multiple cutaneous neurofibromas. Her abdomen was mildly tender in the lower abdomen with no detectable palpable mass. Laboratory test results were as follows: hemoglobin level 9.6g/dL, sedimentation rate 40mm/h, C-reactive protein 23mg/dL. Other biochemical tests were unremarkable. A colonoscopy revealed a normal-appearing colon and an edematous terminal ileum with a 1-cm pedunculated polyp covered by exudate (●" Fig.1). A magnetic resonance enterography showed thickening of the jejunum and terminal ileum, and a pedunculated polyp, about 1cm in diameter, located in the terminal ileum (●" Fig. 2). An oral double-balloon enteroscopy showed multiple, raspberry-like, 3–5mm, sessile polyps, which were covered by faint exudates located in the proximal jejunum (●" Fig.3). Biopsies of the polyps in the jejunum and ileum revealed intestinal ganglioneuromatosis. Type 1 neurofibromatosis, also known as von Recklinghausen disease, may affect the gastrointestinal tract in 25% of patients in whom intestinal neurofibromas, gastrointestinal stromal tumors, or ganglioneuromatosis can be detected [1,2]. Intestinal ganglioneuromatosis is a rare neoplastic condition characterized by proliferation of nerve ganglion cells, nerve fibers, and supporting cells of the enteric nervous system. It occurs in three forms: as an isolated polyp, as multiple polyps (ganglioneuromatous polyposis), and as diffuse involvement of the bowel wall (diffuse intestinal ganglioneuromatosis) [1]. The disease may affect any part of the gastrointestinal tract. The most common symptoms are abdominal pain, change in bowel habit, diarrhea, and gastrointestinal bleeding, which resemble Crohn’s disease.
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- 2015
29. Two gastrointestinal conditions with similar symptoms and endoscopic appearance: irritable bowel syndrome and microscopic colitis
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Hakan Alagözlü, Sahin Coban, Zahide Simsek, Ayse Dursun, Nazife Candan Tunçer, Fatih Karaahmet, [Simsek, Zahide -- Karaahmet, Fatih -- Coban, Sahin] Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Gastroenterol, Ankara, Turkey -- [Tuncer, Nazife Candan] Gazi Univ, Fac Med, Dept Gastroenterol, Ankara, Turkey -- [Alagozlu, Hakan] Cumhuriyet Univ, Fac Med, Dept Gastroenterol, Sivas, Turkey -- [Dursun, Ayse] Gazi Univ, Fac Med, Dept Pathol, Ankara, Turkey, and Sivas Cumhuriyet Üniversitesi
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Adult ,Diarrhea ,Male ,medicine.medical_specialty ,Lymphocytic colitis ,Turkey ,Colon ,Biopsy ,Colonoscopy ,Gastroenterology ,Diagnosis, Differential ,Irritable Bowel Syndrome ,Microscopic colitis ,Bloating ,Internal medicine ,medicine ,Humans ,Colitis ,Irritable bowel syndrome ,Cerrahi ,Collagenous colitis ,medicine.diagnostic_test ,business.industry ,Incidence ,digestive, oral, and skin physiology ,Irritable bowel syndrome,collagenous colitis,lymphocytic colitis ,Disease Management ,General Medicine ,medicine.disease ,digestive system diseases ,collagenous colitis ,Colitis, Microscopic ,lymphocytic colitis ,Female ,medicine.symptom ,Symptom Assessment ,business - Abstract
WOS: 000352482000021, PubMed ID: 26084132, Background/aim: Irritable bowel syndrome (IBS) is a gastrointestinal condition characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any organic cause. This trial investigated the presence of microscopic colitis (MC) and associated factors related to MC in patients diagnosed with IBS. Materials and methods: The study group (group I) consisted of 91 consecutive patients diagnosed with IBS based on the Rome III Criteria for whom colonoscopic examination was requested. The control group (group II) had 41 patients diagnosed with IBS considered as eligible for colonoscopic investigation due to specific conditions, and for whom colonoscopic examination was recommended for screening purposes due to a familial history of colon cancer. Clinical data, endoscopic findings, and the effects of the therapy were evaluated. Results: In the diarrhea-predominant IBS group, nine patients (9.89%) were diagnosed with microscopic colitis, seven with lymphocytic colitis (7.69%), and two with collagenous colitis (CC) (2.19%). None of the patients in group II were found to have MC (P = 0.007). There were no diagnoses of MC in the constipation-predominant and mixed type IBS groups. Conclusion: Clinicians should keep MC in mind for patients presenting with diarrhea-predominant IBS symptoms.
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- 2015
30. Significance of Serum Receptor-Binding Cancer Antigen (RCAS1) in Pancreatic Cancer and Benign Pancreatobiliary Diseases
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Tarik Akar, Sahin Coban, Seyfettin Köklü, and Hasan Özkan
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Adult ,Male ,PCA3 ,CA15-3 ,Pathology ,medicine.medical_specialty ,CA-19-9 Antigen ,CD30 ,Biliary Tract Diseases ,Endocrinology, Diabetes and Metabolism ,CA 15-3 ,Tumor M2-PK ,Adenocarcinoma ,Diagnosis, Differential ,Antigens, Neoplasm ,Pancreatic cancer ,Biomarkers, Tumor ,medicine ,Humans ,Aged ,Tumor marker ,Aged, 80 and over ,Hepatology ,business.industry ,Gastroenterology ,Pancreatic Diseases ,Middle Aged ,Prognosis ,medicine.disease ,Pancreatic Neoplasms ,Female ,CA19-9 ,business - Abstract
RCAS1 is a novel tumor marker, and there are no sufficient data about the utility of this antigen as a serum tumor marker and about its tumor specificity. We aimed at measuring the serum levels of RCAS1 in patients with pancreatic cancer and at determining its diagnostic efficacy.Sera collected from patients with pancreas adenocarcinomas (39 cases) and benign biliary and pancreatic diseases (19 cases) and from healthy volunteers (13 cases) were analyzed for RCAS1 and the results compared with CA19-9. The relation between serum RCAS1 and tumor stage was also evaluated.The serum RCAS1 levels exceeded the normal limit in 92.3, 26.3, and 23.0% of the patients with pancreatic cancer and benign biliary and pancreatic diseases and healthy volunteers, respectively. RCAS1 had a specificity similar to that of CA19-9 in pancreatic cancer, whereas RCAS1 had a higher sensitivity (p0.05). Both tumor markers had similar predictive values of positive and negative tests for pancreatic cancer. The RCAS1 level was less influenced than the CA19-9 level by biliary stenoses. The median serum levels of RCAS1 increased, as the tumor stage increased.RCAS1 is a valuable serum marker for the diagnosis of pancreatic cancer. The RCAS1 and CA19-9 levels increase the diagnostic efficiency of each other in pancreatic cancer.
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- 2006
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31. The Utility of Serum Receptor-Binding Cancer Antigen Expressed on Siso Cells in Gastrointestinal Tract Cancers
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Seyfettin Köklü, Sahin Coban, Muhammed Cem Koçkar, Tarik Akar, Necati Örmeci, Hasan Özkan, and Osman Yüksel
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Adult ,Male ,Pathology ,medicine.medical_specialty ,CA-19-9 Antigen ,Esophageal Neoplasms ,Adenocarcinoma ,Sensitivity and Specificity ,Carcinoembryonic antigen ,Antigen ,Antigens, Neoplasm ,Predictive Value of Tests ,Stomach Neoplasms ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm Invasiveness ,lcsh:RC799-869 ,Aged ,Gastrointestinal Neoplasms ,Neoplasm Staging ,Gastrointestinal tract ,biology ,business.industry ,Gastroenterology ,Case-control study ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Carcinoembryonic Antigen ,Cancer antigen ,Case-Control Studies ,Lymphatic Metastasis ,Colonic Neoplasms ,Carcinoma, Squamous Cell ,biology.protein ,Immunohistochemistry ,Female ,Original Article ,lcsh:Diseases of the digestive system. Gastroenterology ,business - Abstract
BACKGROUND: Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a novel tumour marker that has been described in various kinds of cancer. The majority of observations include immunohistochemical studies; however, there are not enough data about the utility of this antigen as a serum tumour marker and its tumour specificity.AIM: To measure the serum levels of RCAS1 in patients with gastrointestinal (GI) tract cancers and compare them with other GI tract tumour markers.PATIENTS AND METHODS: Sera collected from patients with GI cancers (14 esophagus, 32 gastric and 36 colon) and from healthy volunteers (30 individuals) were analyzed for RCAS1 and compared with carcinoembryonic antigen (CEA) and cancer antigen 19-9. The relationship between serum RCAS1, tumour stage and tumour grade was also evaluated.RESULTS: Mean serum RCAS1 level was higher in patients with GI tract cancers compared with the control group (P=0.001). Among GI tract cancers, RCAS1 had lowest and highest sensitivity for esophagus and colon cancer diagnosis, respectively. Serum RCAS1 had a higher sensitivity for malignancy, except in the colon, and lower specificity in all groups compared with CEA. In comparison with cancer antigen 19-9, serum RCAS1 was more sensitive but less specific for all GI cancer groups. Mean serum RCAS1 levels were not statistically significant among histopathological tumour types (P>0.05). Although serum RCAS1 levels were significantly higher in cases with lymph node involvement compared with lymph node-negative cases (P=0.009), there was no difference between cases with and without serosal involvement, vascular invasion and distant metastasis; no correlation was found between tumour size and RCAS1 levels.CONCLUSIONS: RCAS1 may be used and combined with CEA as a tumour marker in GI tract cancers.
- Published
- 2006
32. Antituberculous therapy–induced fulminant hepatic failure: Successful treatment with liver transplantation and nonstandard antituberculous therapy
- Author
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Hakan Bozkaya, Sahin Coban, Sadık Ersöz, Ramazan Idilman, and Özlem Özdemir Kumbasar
- Subjects
Adult ,Transplantation ,medicine.medical_specialty ,Hepatology ,business.industry ,medicine.medical_treatment ,Isoniazid ,Antitubercular Agents ,Liver Failure, Acute ,Pyrazinamide ,Liver transplantation ,Jaundice ,Liver Transplantation ,Surgery ,Fulminant hepatic failure ,medicine ,Humans ,Female ,medicine.symptom ,business ,Rifampicin ,Ethambutol ,medicine.drug - Abstract
Standard antituberculous therapy including isoniazid, rifampin, ethambutol, and pyrazinamide is widely used for the treatment of active tuberculosis. Its most important side effect is hepatotoxicity, ranging from asymptomatic transaminitis to fulminant hepatic failure. A 19-year-old woman was admitted to our unit due to jaundice and unconsciousness. According to her past medical history, she was diagnosed as having extrapulmonary tuberculosis and had been prescribed standard antituberculous therapy. The patient became icteric and unconscious on the fourth day after therapy initiation. She was diagnosed with drug-induced acute fulminant hepatic failure and underwent living-related liver transplantation. Nonhepatotoxic antituberculous therapy (cycloserine, ciprofloxacin, streptomycin, and ethambutol) and low-dose immunosuppressive therapy were started after transplantation. Currently the patient is very well with normal graft function 42 months after transplantation. Here we report a case of a patient with acute fulminant hepatic failure caused by isoniazid, rifampicin, or both, who was successfully treated with living-related liver transplantation and a relatively less hepatotoxic antituberculous therapy. In conclusion, liver transplantation is a feasible therapy for individuals with standard antituberculous therapy-induced hepatic failure. Nonhepatotoxic antituberculous therapy may achieve control of active tuberculosis in such individuals after transplantation.
- Published
- 2006
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33. Report of 24 Left-Sided Portal Hypertension Cases: A Single-Center Prospective Cohort Study
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İbrahim Ertuğrul, Osman Yüksel, Seyfettin Köklü, Burhan Şahin, Sahin Coban, Engin Uçar, Mehmet Arhan, Mehmet Ibis, Ömer Faruk Yolcu, and Ömer Başar
- Subjects
Adult ,Male ,medicine.medical_specialty ,Gastrointestinal bleeding ,Turkey ,Physiology ,medicine.medical_treatment ,Severity of Illness Index ,Risk Factors ,Hypertension, Portal ,medicine ,Humans ,Prospective Studies ,Elective surgery ,Prospective cohort study ,Aged ,Academic Medical Centers ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Middle Aged ,medicine.disease ,Surgery ,Endoscopy ,Treatment Outcome ,Splenic vein ,Therapeutic endoscopy ,Portal hypertension ,Female ,Radiology ,business ,Varices ,Follow-Up Studies - Abstract
Our aim was to analyze patients diagnosed with left-sided portal hypertension prospectively and to document the complications at follow-up. Twenty-four patients with isolated splenic vein thrombosis (diagnosed by ultrasonography or angiography or intraoperatively) and/or isolated fundal varices (diagnosed by endoscopy or endosonography) were involved in this study. Demographics, clinical presentation, diagnostic and therapeutic procedures, and morbidity and mortality were recorded in their follow-up. There were 11 and 13 left-sided portal hypertension cases associated with pancreatic diseases and nonpancreatic disorders, respectively. Chronic abdominal pain and gastrointestinal bleeding were the two most common complaints. All patients except one had isolated esophageal (2 cases) or fundal (21 cases) varices. Thirteen patients had splenomegaly on ultrasonography. On Doppler sonography, the splenic vein could be evaluated in 21 of the 24 patients (9 and 6 had complete and partial occlusion, respectively, and 6 had patent blood flow). Urgent intervention with therapeutic endoscopy and splenectomy was performed for two patients each. Medical therapy was begun for three patients according to the underlying diseases. Three patients underwent elective surgery. Two patients were lost to follow-up after the first visit and the mean follow-up of the remaining 22 patients after diagnosis of left-sided portal hypertension was 20 months. Only one patient (with pancreas cancer) had gastrointestinal bleeding at follow-up. All patients with pancreas and gastric cancer died within 2-12 months. Left-sided portal hypertension has various etiologies. It may be difficult to diagnose this entity both endoscopically and radiologically. Treatment should be directed at the underlying diseases. Recurrent hemorrhage due to left-sided portal hypertension is not usual and the prognosis depends mainly on the underlying etiology.
- Published
- 2005
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34. Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer
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Elife Erarslan, Akif Altinbas, Serta Kilincalp, Bora Aktaş, Osman Yüksel, Mehmet Raşit Ayte, Ömer Başar, Sahin Coban, Yaşar Tuna, Halil Erbiş, Fuat Ekiz, Nurcan Başar, Engin Uçar, and Baris Yilmaz
- Subjects
Male ,Pathology ,retrospective study ,Disease ,postoperative period ,Gastroenterology ,disease marker ,middle aged ,clinical article ,receiver operating characteristic ,stomach cancer ,Mortality rate ,Hematology ,General Medicine ,Middle Aged ,biological marker ,Gastric surgery ,preoperative evaluation ,female ,Tumor Markers, Biological ,Hepatocellular carcinoma ,Biomarker (medicine) ,Adenocarcinoma ,Female ,cancer surgery ,Mean Platelet Volume ,early diagnosis ,medicine.medical_specialty ,Mean platelet volume ,Article ,blood ,Stomach Neoplasms ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,controlled study ,diagnostic test accuracy study ,human ,preoperative period ,Aged ,Retrospective Studies ,business.industry ,cancer staging ,Cancer ,medicine.disease ,mortality ,thrombocyte volume ,sensitivity and specificity ,Heart failure ,tumor marker ,adverse effects ,Gastric cancer ,business ,metabolism - Abstract
Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths worldwide. The early diagnosis of gastric cancer is fundamental in decreasing the mortality rates. It has been shown that MPV level is a sign of inflammation in hepatocellular carcinoma and pancreatic adenocarcinoma. The aim of this study is to examine whether MPV would be a useful inflammatory marker for differentiating gastric cancer patients from healthy controls. Thirty-one gastric cancer patients and 31 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. MPV level was significantly higher in pre-operative gastric cancer patients compared to healthy subjects (8.31 fL vs. 7.85; p: 0.007). ROC analysis suggested 8.25 fL as the cut-off value for MPV (AUC: 0.717, sensitivity: 61%, specificity: 81%). Surgical tumor resection resulted in a significant decrease in MPV level (8.31 fL vs. 7.55 fL; p: 0.001). No significant difference was found in MPV level between the post-operative group and control subjects. We did not find statistically significant difference between MPV and TNM stages. In conclusion, changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients for GC risk and may prompt physicians to make an early diagnosis of GC. © 2014 Informa UK Ltd.
- Published
- 2013
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35. CASE REPORT: Intestinal Obstruction in Celiac Disease: Case Report
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Ömer Başar, Sahin Coban, Necati Örmeci, Seyfettin Köklü, İbrahim Ertuğrul, Arzu Ensari, and Aynur Akyol
- Subjects
Intestinal pseudo-obstruction ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,Physiology ,business.industry ,Gastroenterology ,Disease ,Hepatology ,Anastomosis ,medicine.disease ,Coeliac disease ,Endoscopy ,Internal medicine ,Immunopathology ,Medicine ,Intestinal obstruction surgery ,business - Published
- 2004
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36. Shark liver oil: hidden dangers
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Murat Deveci, Sahin Coban, Serta Kilincalp, Osman Yüksel, Fuat Ekiz, and Ömer Başar
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Fishery ,RC581-951 ,Hepatology ,business.industry ,Specialties of internal medicine ,Medicine ,Shark liver oil ,General Medicine ,business - Published
- 2012
- Full Text
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37. The clinical and histopathological presentations of patients with gastrointestinal stromal tumors
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Necati Örmeci, Akif Altinbas, Berna Savaş, Ömer Başar, Arzu Ensari, Fuat Ekiz, Hatice Ünverdi, Sahin Coban, Bora Aktaş, and Baris Yilmaz
- Subjects
medicine.medical_specialty ,lcsh:R5-920 ,Stromal cell ,business.industry ,lcsh:R ,clinical presentation ,lcsh:Medicine ,Gastroenterology ,digestive system diseases ,histopathological examination ,Internal medicine ,medicine ,Gastrointestinal stromal tumors ,business ,lcsh:Medicine (General) - Abstract
Objectives: Gastrointestinal stromal tumors (GIST) are originated from mesenchymal / stromal cells and are rarely seen in gastrointestinal tract. In this study, we aimed to determine the clinical and histopathological presentations, and tumor localizations of the patients with GIST.Materials and methods: Totally, 18 patients were included in the study. Ten patients were male (56%), and the mean age was 54.2 (30-75) years.Results: The most common sites of organs involved are stomach, peritonea, colon, small intestine, omentum and esophagus, respectively. The major symptom of the patients with GIST is abdominal pain. Distant organ metastasis was detected in 22.2% of the patients.Conclusion: We found that the most common presentation of patients with GIST is abdominal pain, and the most common involved organ is the stomach.
- Published
- 2012
38. A condition of unknown significance: esophageal melanocytosis in a patient with celiac disease
- Author
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Mevlut Hamamci, Fatih Karaahmet, Sahin Coban, Akif Altinbas, and Baris Yilmaz
- Subjects
Melanins ,medicine.medical_specialty ,Pathology ,business.industry ,Biopsy ,Gastroenterology ,Disease ,Dermatology ,Celiac Disease ,Unknown Significance ,Esophagus ,Medicine ,Humans ,Melanocytes ,Female ,business ,Aged - Published
- 2014
39. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma
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İlhami Yüksel, Yusuf Coskun, Fatih Karaahmet, Zahide Simsek, Hakan Akinci, Serta Kilincalp, Sahin Coban, Mevlut Hamamci, Elife Erarslan, and Yusuf Üstün
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Epidemiology ,Colorectal cancer ,Neutrophils ,Lymphocyte ,Adenocarcinoma ,Gastroenterology ,Sensitivity and Specificity ,Letter to the Editor: Colorectal Cancer ,Hemoglobins ,Leukocyte Count ,Internal medicine ,medicine ,Humans ,Colorectal adenocarcinoma ,Platelet ,Lymphocyte Count ,Mean platelet volume ,Early Detection of Cancer ,Aged ,Retrospective Studies ,business.industry ,Platelet Count ,Public Health, Environmental and Occupational Health ,Case-control study ,Retrospective cohort study ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Oncology ,Potential biomarkers ,Case-Control Studies ,Immunology ,Female ,business ,Colorectal Neoplasms ,Mean Platelet Volume ,Biomarkers - Abstract
Colorectal cancer (CRC) is the third most common cause of cancer-related death in Europe. The aim of the present study was to elucidate the efficiency of the neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and the mean platelet volume (MPV) as tools for the preoperative diagnosis of CRC and their usefulness in the follow-up of CRC. A total of 144 CRC patients, as diagnosed by colonoscopy, and 143 age-matched and sex-matched healthy participants were included in the study. Medical records were used to compare preoperative and postoperative data including hemoglobin levels, platelet counts, MPV, NLR, and PLR. NLR, PLR, and MPV were significantly higher in CRC patients preoperatively, compared with healthy participants. Receiver-operating characteristic curve analysis suggested 2.02 as the cutoff value for NLR [area under the curve (AUC): 0.921, sensitivity: 86%, specificity: 84%], 135 as the cutoff value for PLR, (AUC: 0.853, sensitivity: 70%, specificity: 90%) and 8.25 fl as the cutoff value for MPV (AUC: 0.717, sensitivity: 54%, specificity: 76%). Subgroup analysis showed that NLR, PLR, and MPV levels were also significantly higher in nonanemic CRC patients compared with the control group, which is of great theoretical and clinical value for the early detection of CRC. Surgical tumor resection resulted in a significant decrease in NLR, PLR, and MPV. Our results suggest that NLR, PLR, and MPV may be used as easily available additional biomarkers for CRC in screening the general population, as well as in postoperative follow-up.
- Published
- 2014
40. A rare entity: Cystic lymphangioma of the duodenal bulb and successful treatment with polypectomy in an adult patient
- Author
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Sahin Coban, Zahide Simsek, Bora Aktaş, Ata Turker Arikok, and Baris Yilmaz
- Subjects
Adult ,Male ,medicine.medical_specialty ,Gastrointestinal tract ,business.industry ,Endoscopic biopsy ,medicine.medical_treatment ,Gastroenterology ,Rare entity ,medicine.disease ,Polypectomy ,Endoscopy, Gastrointestinal ,Surgery ,Abdominal Pain ,body regions ,medicine.anatomical_structure ,Duodenal Neoplasms ,parasitic diseases ,Lymphangioma ,Duodenal bulb ,medicine ,Humans ,Lymphangioma, Cystic ,business ,Deep bite - Abstract
Gastrointestinal tract lymphangiomas are extremely rarely seen. Here, we present the first case of lymphangioma of the duodenal bulb diagnosed with a deep bite on a bite endoscopic biopsy and treated with polypectomy.
- Published
- 2014
41. Will a second biopsy sample affect treatment decisions in patients with chronic hepatitis B?
- Author
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Ata Turker Arikok, Osman Yüksel, Ömer Başar, Akif Altinbas, Bora Aktaş, İlhami Yüksel, Murat Deveci, Fuat Ekiz, Sahin Coban, and Baris Yilmaz
- Subjects
Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Pathology ,Biopsy ,Decision Making ,Gastroenterology ,Sensitivity and Specificity ,Specimen Handling ,03 medical and health sciences ,0302 clinical medicine ,Hepatitis B, Chronic ,Internal medicine ,Medicine ,Humans ,Grading (tumors) ,Observer Variation ,Hepatology ,medicine.diagnostic_test ,business.industry ,Hepatitis C ,Hepatitis B ,Middle Aged ,medicine.disease ,Colorectal surgery ,030220 oncology & carcinogenesis ,Liver biopsy ,030211 gastroenterology & hepatology ,Female ,Steatohepatitis ,business - Abstract
Liver biopsy is the gold standard for assessment of fibrosis in patients with hepatitis B. However, it has some disadvantages, including inter-observer and intra-observer variability in biopsy interpretation and specimen variation. A standard biopsy specimen represents only about 0.0002 % of the whole liver. It has been shown that two biopsy samples collected during a procedure have significant influence on the diagnostic performance of interpretation in patients with hepatitis C or non-alcoholic steatohepatitis. Therefore, we aimed to assess the influence of collecting two liver biopsy samples during a single procedure for staging and grading chronic hepatitis B.27 patients were included in the study. The median age of the patients was 43.51 ± 11.69. Fifteen patients were female, 12 patients were male. In the biopsy procedure, two samples of liver lobes were obtained. Grade and stage scores were compared between the two samples. Fibrosis staging and grading were assessed according to the Ishak scoring system.Numbers of portal tract and biopsy size were equal in the two samples. There was a significant difference between the samples in terms of histological activity index (p value = 0.04). However, the difference was not enough to distinguish the mild and moderate stages. On the other hand, no significant difference in fibrosis staging between the two samples was found.With this relatively small size of patients, in this study, we showed that a proper liver biopsy size is sufficient to predict treatment decisions in chronic hepatitis B patients. However, further studies are needed to show the association of sampling variability in patients with hepatitis B.
- Published
- 2014
42. Approach and management of patients with chronic hepatitis B and C during the course of inflammatory bowel disease
- Author
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Murat Kekilli, Sahin Coban, and Seyfettin Köklü
- Subjects
medicine.medical_specialty ,Hepatitis B virus ,Hepacivirus ,medicine.disease_cause ,Inflammatory bowel disease ,Antiviral Agents ,Hepatitis B, Chronic ,Risk Factors ,medicine ,Immunology and Allergy ,Humans ,Disease management (health) ,Intensive care medicine ,biology ,business.industry ,Public health ,Gastroenterology ,Disease Management ,Hepatitis C ,medicine.disease ,biology.organism_classification ,Inflammatory Bowel Diseases ,Prognosis ,Vaccination ,business ,Viral hepatitis ,Immunosuppressive Agents - Abstract
Inflammatory bowel disease and chronic viral hepatitis are 2 distinct but common conditions throughout the world. Mostly, both need life-long follow-up. Since immunosuppressive drugs remain corner stones of inflammatory bowel disease management, one should be aware of the concomitant presence of chronic viral hepatitis in such patients to prevent serious (even fatal) outcomes. Recently, new treatment options have become available in the treatment of both inflammatory bowel disease and chronic viral hepatitis. In this review, we have discussed and summarized current treatment and follow-up strategies for those 2 important public health issues in light of available literature.
- Published
- 2014
43. Does long-term metformin usage reduce gastric cancer risk?
- Author
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Sahin Coban
- Subjects
Oncology ,Male ,medicine.medical_specialty ,business.industry ,Gastroenterology ,MEDLINE ,medicine.disease ,Metformin ,Term (time) ,Diabetes Mellitus, Type 2 ,Stomach Neoplasms ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Hypoglycemic Agents ,Female ,Cancer risk ,business ,medicine.drug - Published
- 2014
44. Successful ERCP in a patient with situs inversus
- Author
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Ömer Başar, Sahin Coban, Metin Kucukazman, and İlhami Yüksel
- Subjects
Cholangiopancreatography, Endoscopic Retrograde ,medicine.medical_specialty ,business.industry ,Gastroenterology ,MEDLINE ,Middle Aged ,medicine.disease ,Situs Inversus ,Surgery ,Situs inversus ,Choledocholithiasis ,medicine ,Humans ,Female ,Ultrasonography ,business - Published
- 2014
45. Large nylon bag causing gastric outlet obstruction in a patient with schizophrenia
- Author
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Hakan Akinci, Mevlut Hamamci, Fatih Karaahmet, and Sahin Coban
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Gastric Outlet Obstruction ,Schizophrenia (object-oriented programming) ,Stomach ,Gastroenterology ,Gastric outlet obstruction ,Middle Aged ,medicine.disease ,Foreign Bodies ,Endoscopy, Gastrointestinal ,Surgery ,Text mining ,medicine ,Schizophrenia ,Humans ,business - Published
- 2014
46. Signet Ring Cell Carcinoma of Both Colon and Pancreas
- Author
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Ömer Başar, Fatih Karaahmet, Gulden Aydoğ, Osman Yüksel, and Sahin Coban
- Subjects
Pathology ,medicine.medical_specialty ,Rectal Carcinoid ,Signet ring cell ,business.industry ,Gastroenterology ,medicine.disease ,Endoscopic drainage ,medicine.anatomical_structure ,Oncology ,Signet ring cell carcinoma ,Carcinoma ,medicine ,Superior mesenteric vein ,business ,Pancreas - Published
- 2015
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47. A Cutaneous Autoimmune Blistering Disorder Related to Chronic Hepatitis C: Bullous Pemphigoid
- Author
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Hakan Akinci, Sahin Coban, Fatih Karaahmet, İlhami Yüksel, Mevlut Hamamci, and Yasemin Akca
- Subjects
Chronic hepatitis ,business.industry ,Immunology ,medicine ,Bullous pemphigoid ,Geriatrics and Gerontology ,medicine.disease ,business - Published
- 2015
- Full Text
- View/download PDF
48. Adjusting the Patient Positioning During Endoscopy in Diagnosis of Gastrocolic Fistula Related to Advanced Stage Gastric Malignancy
- Author
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Sahin Coban, Mevlut Hamamci, Fatih Karaahmet, Hakan Akinci, and İlhami Yüksel
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General surgery ,medicine.medical_treatment ,Advanced stage ,Gastroenterology ,Patient positioning ,Gastrocolic fistula ,Endoscopy ,Radiation therapy ,Oncology ,medicine ,Gastric malignancy ,business - Published
- 2015
- Full Text
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49. Cytomegalovirus Infection in a Patient with Crohn’s Ileocolitis
- Author
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Mehmet Ayhan Kuzu, Sahin Coban, Arzu Ensari, Necati Örmeci, Murat Palabıyıkoğlu, and Samet Yalcin
- Subjects
Male ,medicine.medical_specialty ,Abdominal pain ,Exacerbation ,medicine.medical_treatment ,Congenital cytomegalovirus infection ,Disease ,Inflammatory bowel disease ,Gastroenterology ,Diagnosis, Differential ,Ileostomy ,Crohn Disease ,Internal medicine ,medicine ,Humans ,Postoperative Period ,lcsh:RC799-869 ,Enterocolitis ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Methylprednisolone ,Cytomegalovirus Infections ,lcsh:Diseases of the digestive system. Gastroenterology ,medicine.symptom ,business ,medicine.drug - Abstract
Cytomegaloviral enterocolitis is an uncommon infection that can complicate inflammatory bowel disease. A case of a patient with a three-year history of Crohn's disease is reported. He had been in a stable condition on mesalamine 4 g/day and methylprednisolone 10 mg/day for three years until four weeks before admission. The patient was admitted with complaints of fever, abdominal pain and watery diarrhea. A diagnosis of an exacerbation of Crohn's disease was established. The radiological examination revealed narrowing of the terminal ileum. Multiple fistulas and abscess-like images were observed. The patient then underwent ileocolic resection and ileostomy. The histopathological examination revealed Crohn's ileocolitis with superimposed cytomegalovirus infection. In patients with rapidly deteriorating inflammatory bowel disease, cytomegalovirus infection should be kept in mind as one of the differential diagnoses.
- Published
- 2005
50. Letter: a hidden cause of anaemia in inflammatory bowel disease patients - coeliac disease
- Author
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Y. Ustun, F. Karaahmet, Sahin Coban, İlhami Yüksel, and S. Kılıncalp
- Subjects
Male ,medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,MEDLINE ,Anemia ,medicine.disease ,Inflammatory bowel disease ,Coeliac disease ,Crohn Disease ,Internal medicine ,Medicine ,Humans ,Pharmacology (medical) ,Colitis, Ulcerative ,Female ,Colitis ,business - Published
- 2013
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