Author: "SUN, Yi" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

338 results on '"SUN, Yi"'

1. Age-friendly urbanism: intertwining 'ageing in place' and 'place in ageing'

Author: Sun, Yi, Ng, Mee Kam, and Chao, Tzu-Yuan Stessa
Subjects: Urbanization, Urban planning, Architecture and design industries, Business, Business, international
Abstract: Urbanisation and population ageing are two critical trends identified in the New Urban Agenda. Understanding the relationship between environment-related experiences and well-being is conducive to achieving an age-friendly urbanism. We argue that place, as a location, a material form and an expression of value, is an essential component of this relationship. Physical and social environments shape sociospatial experiences and hence one's well-being, bearing significant implications for the current policy movement of ageing in place. Environment comprises contexts whereby older people develop sentimental and emotive links to the place they live. Such links give rise to residential satisfaction and place attachment, the psychological experiences that highlight the importance of place in ageing. The article calls for research and planning practices to shed light on policies concerning age-friendly urbanism. Keywords: ageing, place, well-being, environmental experience, age-friendly urbanism, Introduction: New Urban Agenda and age-friendly urbanism Neo-liberal urbanism is characterised by marketisation and fiscal austerity. (1) Interests for exchange values see land as just an asset for profit making [...]
Published: 2020
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2. Coaxial holographic reconstruction method of micro-milling tool pose

Author: YU Zhan-jiang, Zhang Xiang-hui, Sun Yi-yang, Xu Jinkai, Yu Huadong, and Cheng Ya-ya
Subjects: Materials science, Optics, law, business.industry, Holography, Coaxial, business, Reconstruction method, Atomic and Molecular Physics, and Optics, law.invention
Published: 2022

3. Finite element modeling and experimental testing of woven fabric based on a new instrument: simulative analysis of the compression property

Author: Gui Liu, Zhaoqun Du, Dongdong Lu, Sun Yi, and Xingxing Pan
Subjects: Mechanism (engineering), Materials science, Experimental testing, Polymers and Plastics, business.industry, Property (programming), Woven fabric, Chemical Engineering (miscellaneous), Structural engineering, business, Compression (physics), Finite element method
Abstract: A multi-scale finite element (FE) model including a macro-scale instrument and fabric composed of meso-scale yarns is established so as to deeply understand the compression mechanism of woven fabrics based on the Quick-Intelligent Handle Evaluation System. The compression stress and strain of the fabric and its internal warp and weft yarns are revealed in the FE analysis, and a parameter study involving the friction coefficient, Young’s modulus, yarn spacing and crimp height is addressed to understand the fabric deformation. The results show that fabric parameters have a significant impact on the compression behavior, indicating that the compression performance of the fabric is limited by the nonlinear mechanical and geometric properties of the yarn. Moreover, by comparing the FE modeling and experimental testing, the FE model proved to be sufficient to simulate the compression response of the fabric, so as to predict the compression property based on actual or preset material properties.
Published: 2021

4. A Study on the Effects of the Customer Values of Hairdressing Business on Customer Commitment

Author: Sun-Yi Park
Subjects: Business administration, Business, Customer commitment
Published: 2021

5. The Effect of Relational Benefits on Customer Loyalty in Hair Beauty Salon

Author: Sun-Yi Park and Nayoung An
Subjects: Beauty salon, Advertising, Business, Loyalty business model
Published: 2021

6. Potential impacts of 3D modeling and 3D printing in firearm toolmark examinations

Author: Jorn C. C. Yu, Golightly Scott, Pamela J. Zelbst, Sun Yi Li, and Jennifer Turner
Subjects: Ammunition, Engineering, Comparison microscope, business.industry, Visual examination, Genetics, Forensic engineering, Barrel (horology), 3D printing, business, 3D modeling, Pathology and Forensic Medicine, Gun barrel
Abstract: In this work, two gun barrels were 3D-printed using a metal alloy material from the same 3D digital model created in silico. After assembling the barrels in a reference Colt 45 Auto semi-automatic pistol, a total of 100 rounds of ammunition were successfully test-fired through each barrel. Heavy and gross striations were observed on all fired bullets. The striations on bullets discharged from the corresponding 3D-printed gun barrel were found to be identifiable. Moreover, bullets fired from one 3D-printed gun barrel were easily excluded from those fired from the other 3D-printed gun barrel by visual examination under a comparison microscope. The resulting unconventional striations that were observed were apparent to an experienced firearm and toolmark examiner. These features could provide valuable investigative leads related to the 3D printing process. Since 3D printing has become an option for firearm manufacturing, the forensic science community should establish a knowledge base associated with the toolmark features generated by the 3D-printed products.
Published: 2021

7. Effects of Intake Components on Combustion and Emission Characteristics in an n‑Butanol/Diesel Blend Fueled Engine

Author: Fu Dongqi, Sun Yi, Yuying Yan, Xin Zhang, Wanchen Sun, Jun Li, Liang Guo, and Hao Zhang
Subjects: Thermal efficiency, business.industry, General Chemical Engineering, Analytical chemistry, chemistry.chemical_element, Fraction (chemistry), General Chemistry, Particulates, Combustion, Oxygen, Article, chemistry.chemical_compound, Diesel fuel, Chemistry, chemistry, n-Butanol, Exhaust gas recirculation, business, QD1-999
Abstract: To assess the effects of intake components and n-butanol application on compression-ignition engines, an experiment was carried out based on a single-cylinder engine fueled with n-butanol/diesel-blended fuel. The results show that with the increased n-butanol fraction of the blended fuel, the emissions of particulate mass (PM) decrease significantly, but the NO x and hydrocarbon (HC) emissions deteriorate. For B15 and B30, the PM emissions are 66.2% and 74.4% lower than B0, respectively. Furthermore, exhaust gas recirculation (EGR) was introduced to reduce the NO x emissions. However, a large EGR rate significantly reduces the indicated thermal efficiency (ITE) of the engine. Compared with the non-EGR condition, the ITE of B15 and B30 decrease by 3.1% and 3.8%, respectively, when the EGR rate is 18%. At the same time, the PM and HC emissions are found to be increased greatly. The PM emission of B15 and B30 increases by 69% and 46% and the HC emission increase by 150% and 71%, respectively. To restrain the engine emissions caused by the EGR, pure oxygen is further introduced into the intake charge. It is found that both the PM and HC emissions are significantly reduced with the introduction of extra oxygen. Under the condition of the 18% EGR rate, increasing oxygen addition to 4% can reduce HC emissions by more than 50% and the total particle mass of B15 and B30 is reduced by 60.6% and 47.7%, respectively. Moreover, the ITE reduction and combustion deterioration caused by the large EGR are found to be alleviated. By adjusting the n-butanol ratio, EGR rate, and oxygen addition, the excellent performance of combustion and emission can be achieved in an n-butanol/diesel blend fueled engine.
Published: 2021

8. Multi-area joint scheduling model considering peak load regulating of nuclear power

Author: Qiang Ding, Dan Xu, Zhi Cai, Guofang Zhang, Sun Yi, and Guo Xiaming
Subjects: Integrated scheduling, Wind power, business.industry, Computer science, 020209 energy, Scheduling (production processes), 02 engineering and technology, Nuclear power, Tie-line scheduling, Automotive engineering, Power (physics), Nuclear power unit, Electric power system, General Energy, Base load power plant, 020401 chemical engineering, Peak demand, Wind power accommodation, 0202 electrical engineering, electronic engineering, information engineering, lcsh:Electrical engineering. Electronics. Nuclear engineering, 0204 chemical engineering, business, Energy source, lcsh:TK1-9971
Abstract: As the use of clean energy such as wind power and nuclear power has been increasing, the base load operation of nuclear power units usually means huge pressure for local power systems in regulating peak demand. In order to use more regulation resources, a multi-area joint optimization model involving peak regulating of nuclear power is proposed. Match performance of peak load regulating of wind power and nuclear power is also examined according to their output characteristics. Furthermore, aiming to make nuclear power constraint linearize, a method is introduced herein to subdivide the depth of peak load regulating of nuclear power. On the other hand, considering the power constraints of AC/DC transmission channel, wind curtailment cost and the operating cost of peak load regulating of nuclear power, a joint scheduling model with complementary energy sources in multi-area is established, which can effectively reduce the adverse impact of negative peak regulating of wind power and enhance consumption of clean energy. Finally, China’s inter-regional interconnected power system is introduced to validate the effectiveness of the proposed model.
Published: 2021

9. LOPE: A Low‐Overhead Payment Verification Method for Blockchains

Author: Zhang Ying, HE Zhengyuan, Sun Yi, Jia Linpeng, Ding Donghui, and Zhang Hanwen
Subjects: Traceability, Computer science, business.industry, Applied Mathematics, Hash function, Testbed, Overhead (business), Electrical and Electronic Engineering, Performance improvement, business, Byzantine fault tolerance, Protocol (object-oriented programming), Computer network, Block (data storage)
Abstract: With its characteristics of decentralization, security, data traceability, and tamper-resistance, the blockchain has been widely used in various domains. Considering the difference in the performance of the devices, the light client is proposed so that devices without the ability to store a full blockchain copy can also participate in the blockchain transactions. However, the light client has to communicate with full nodes and verify the authenticity of a transaction which brings in some extent of communication, computation, and storage overheads to the light client. These overheads cannot be ignored for some low-performance devices, such as embedded devices or IoT chips, and therefore the current light client scheme does not work in this situation. We propose LOPE (a Low-overhead payment vErification method) for poor-capacity nodes in the blockchain system. In LOPE, a grouping protocol is designed to partition full nodes into groups to serve the verification requests of the light client. In addition, Practical byzantine fault tolerance (PBFT) is used to ensure the light client to get a credible result in spite of a few dishonest nodes existing in the group. We conduct LOPE and evaluate it in a testbed. The experiment results show that LOPE reduces more than half of the communication overhead, degrades the computation overhead of the light client to a large extent, and avoids the storage overhead of the hash roots of block headers in the light client. We also conduct theoretical analysis to show the performance improvement and security issues of LOPE.
Published: 2021

10. A study on the new donation system using donor's psychology by types of donation-Focused on the possibility of donation through item disposal behavior

Author: Jae-sun Yi, Bo-kyeong Kim, Ji-hye Han, and So-ri Lim
Subjects: Medical education, business.industry, Service design, Donation, General Medicine, Psychology, business
Published: 2021

11. Neurological Measurement of Human Trust in Automation Using Electroencephalogram

Author: Seeung Oh, Sun Yi, Sangsung Park, and Younho Seong
Subjects: Computational Theory and Mathematics, Artificial Intelligence, Logic, business.industry, Computer science, Embedded system, Signal Processing, business, Automation, Computer Science Applications
Published: 2020

12. A Study of the Senior Serviced Housing for Urban Renewal New Deal of Community Care Type

Author: Seong Hwa Lee and Sun Yi Hong
Subjects: New Deal, Business, Public administration
Published: 2020

13. Effect of herb-partitioned moxibustion in improving tight junctions of intestinal epithelium in Crohn disease mediated by TNF-α-NF-κB-MLCK pathway

Author: Zhou Jing, Sun Yi, Guo Ya-jing, Wang Yi-ran, Gao Yan-ling, Zhao Jimeng, Shi Yin, Wang Yu-ning, and Wu Huangan
Subjects: Myosin light-chain kinase, Tight junction, medicine.diagnostic_test, Kinase, business.industry, 0211 other engineering and technologies, NF-κB, 02 engineering and technology, Occludin, Intestinal epithelium, Molecular biology, 030205 complementary & alternative medicine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Complementary and alternative medicine, chemistry, Western blot, 021105 building & construction, Medicine, Tumor necrosis factor alpha, business
Abstract: To explore the effect of herb-partitioned moxibustion (HPM) on tight junctions (TJs) of intestinal epithelial cells in Crohn disease (CD) mediated by tumor necrosis factor-α (TNF-α)-nuclear factor kappa B (NF-κB)-myosin-light-chain kinase (MLCK) pathway. Forty-eight male Sprague-Dawley rats were randomly divided into a normal control (NC) group, a model control (MC) group, an HPM group and a mesalazine (MESA) group, with 12 rats in each group. Trinitrobenzene sulfonic acid (TNBS) was administered to establish CD models. When the model was confirmed a success, the HPM group rats were treated with HPM at Tianshu (ST 25) and Qihai (CV 6), while the MESA group rats were given MESA solution by lavage. When the intervention finished, the colonic epithelial tissues were separated, purified and cultured in each group to establish the intestinal epithelial barrier model in vitro, and TNF-α was added (100 ng/mL) in the culture medium and maintained for 24 h to establish an increased epithelial permeability model. Transepithelial electrical resistance (TEER) was used to examine the permeability of the barrier; Western blot was used to observe the expressions of the proteins related to TJs of intestinal epithelial cells mediated by TNF-α-NF-κB-MLCK pathway; immunofluorescence staining was used to observe the expressions and distributions of tight junction proteins in the intestinal epithelium. After TNF-α induction, compared with the MC+TNF-α group, the TEER value increased significantly in the HPM+TNF-α and MESA+TNF-α groups (both P
Published: 2020

14. P‐13: Large Subthreshold Swing of LTPS TFTs by Efficient Annealing Method for Light Emitting Diode Displays

Author: Takao Saito, Miwa Masahiko, Kaneko Seiji, Sun Yi, Yoshiharu Kataoka, Yosuke Kanzaki, and Yamanaka Masaki
Subjects: Materials science, business.industry, Annealing (metallurgy), law, Subthreshold swing, Optoelectronics, business, Light-emitting diode, law.invention
Published: 2020

15. PRDX4 overexpression is associated with poor prognosis in gastric cancer

Author: Sun Yi Park, Tae Han Kim, Hee Jin Park, Sang-Ho Jeong, Young Tae Ju, Dae Hyun Song, Young-Joon Lee, Gyung Hyuck Ko, Jiyun Yoo, Soon-Chan Hong, Eun-Jung Jung, Ji-Ho Park, Chi Young Jeong, and Miyeong Park
Subjects: 0301 basic medicine, Stomach neoplasm, Cancer Research, Cell, survival analysis, Small hairpin RNA, 03 medical and health sciences, 0302 clinical medicine, Medicine, Gene knockdown, peroxiredoxin IV, Oncogene, business.industry, Cancer, biomarkers, Articles, Cell cycle, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer cell, stomach neoplasm, Cancer research, prognosis, business
Abstract: Peroxiredoxin IV (PRDX4) is a multifunctional protein that is involved in cell protection against oxidative injury, regulation of cell proliferation, modulation of intracellular signaling, and the pathogenesis of tumors. We previously conducted a proteomic analysis to investigate tumor-specific protein expression in gastric cancer. The aim of the present study was to investigate whether PRDX4 could be a marker of poor prognosis in patients with gastric cancer. Immunohistochemistry was used to validate PRDX4 as a prognostic marker for gastric cancer. Short hairpin RNA (shRNA)-mediated knockdown of PRDX4 expression in AGS cells and MKN28 cells was used for functional studies, and PRDX4 overexpression in PRDX4-depleted cells was used for knock-in studies. Based on immunohistochemistry data, TNM stage and PRDX4 were independent prognostic factors in the Cox proportional hazard model (P
Published: 2020

16. System design of camera for coded exposure

Author: Sun Yi, Li Xiang, and LI Mingwei
Subjects: business.industry, Computer science, Systems design, Computer vision, Artificial intelligence, business, Atomic and Molecular Physics, and Optics
Published: 2020

17. Defect Detection on 3D Print Products and in Concrete Structures Using Image Processing and Convolution Neural Network

Author: Selorm Garfo, Sun Yi, and M.A. Muktadir
Subjects: 3d print, Computer science, business.industry, Computer vision, Image processing, Artificial intelligence, business, Convolutional neural network
Published: 2020

18. COMBINATION OF BERBERINE AND MATRINE AFFECTS APOPTOSIS AND CELLCYCLE IN HUMAN CERVICAL CANCER CELLS

Author: Sun Yi, Song Yijun, Yuxi Huang, Chongbo Zhao, Qijiayu Zhang, Juanhua Wu, and Sun Jing
Subjects: Pharmacology, chemistry.chemical_compound, Berberine, Matrine, chemistry, Apoptosis, business.industry, Cervical carcinoma, Cancer research, Pharmaceutical Science, Medicine, Cell cycle, business
Published: 2019

19. Adaptive Smith Predictor for Teleoperation of UAVs with Time-varying Internet Delay

Author: Christopher Thomas, Shava Meadows, Sun Yi, and Ryan E. Sherrill
Subjects: 0209 industrial biotechnology, Computer science, business.industry, Robotics, 02 engineering and technology, Delay differential equation, Networked control system, Mechatronics, Computer Science Applications, Smith predictor, 020901 industrial engineering & automation, Control and Systems Engineering, Control theory, Teleoperation, The Internet, Artificial intelligence, Latency (engineering), business
Abstract: Time delay in a networked control system can negatively impact the performance of the system. Dynamic networks with unknown and varying latency such as the Internet are studied. Also, experiments with teleoperation of drones and communication loops through the Internet are conducted. Smith Predictors are well known for their ability to handle time delay. Smith Predictor controllers perform well when modeled accurately and when the delay is known. The proposed method combines a delay estimation technique based on characteristic roots of delay differential equations to measure the delay with an Adaptive Smith Predictor. When the delay parameter is adjusted correctly, the negative effects caused by delay are significantly reduced. The proposed method performs satisfactory for networked systems with unknown delay and the results are validated through simulations and experimentation.
Published: 2019

20. Transmission Electron Microscopy Confirmation of Orientia tsutsugamushi in Human Bile

Author: Ha Young Lee, Chang-Seop Lee, Edmond Changkyun Park, Sangmi Jun, Hwang Jm, Seung Il Kim, Yujeong Lee, and Yoon-Sun Yi
Subjects: Microbiology (medical), Transmission Electron Microscopy Confirmation of Orientia tsutsugamushi in Human Bile, Pathology, medicine.medical_specialty, Orientia tsutsugamushi, Epidemiology, Human bile, vector-borne infections, 030231 tropical medicine, human bile, lcsh:Medicine, Eschar, Scrub typhus, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Microscopy, Electron, Transmission, South Korea, Republic of Korea, transmission electron microscopy, Research Letter, medicine, Bile, Humans, lcsh:RC109-216, 030212 general & internal medicine, bacteria, Orientia, scrub typhus, biology, integumentary system, business.industry, Gallbladder, lcsh:R, biology.organism_classification, medicine.disease, bacterial infections and mycoses, Infectious Diseases, medicine.anatomical_structure, PCR, coccobacillus, Coccobacillus, Infectious disease (medical specialty), Ultrastructure, medicine.symptom, business, eschar
Abstract: Scrub typhus, the third most frequently reported infectious disease in South Korea, causes serious public health problems. In 2019, we collected a bile specimen from a patient with scrub typhus through percutaneous transhepatic gallbladder drainage and performed transmission electron microscopy to confirm the ultrastructure of Orientia tsutsugamushi.
Published: 2020

21. Bean extract-based gargle for efficient diagnosing COVID-19 at early-stage using rapid antigen tests : a clinical, prospective, diagnostic study

Author: Eunae Jo, Dal Sik Kim, Jeong-Hwan Hwang, Sun Cheol Park, Yuxi Lin, Hye-Yeon Kim, Sangmi Jun, Soyoung Cha, Jong-Soon Choi, Kyeong Eun Yang, Kyuhong Lee, Hee-Chung Chung, Hwang Jm, Bipin Vaidya, Sang Min Lee, Duwoon Kim, Sung Ho Yun, Young-Ho Lee, Eunha Hwang, Namsu Kim, Dai Ito, Mi-Kyung Song, Joseph Sang-Il Kwon, Dong Im Kim, Euna Ko, Se-Young Cho, and Yoon-Sun Yi
Subjects: Rapid diagnostic test, Saliva, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Asymptomatic, Clinical trial, Antigen, Internal medicine, Medicine, Stage (cooking), medicine.symptom, business, Mass screening
Abstract: ImportanceThe antigen-based rapid diagnostic test (Ag-RDT), using saliva specimens, is fast, non-invasive and suitable for SARS-CoV-2 self-testing, unlike nasopharyngeal swab (NPS) testing.ObjectiveTo assess the diagnostic sensitivity of a novel Beanguard gargle™ (BG)-based virus detection method for early diagnosis of COVID-19.DesignThis clinical trial was conducted at Gunsan Medical Center, Namwon Medical Center, and Jeonbuk National University Hospital, between May 7 and July 7, 2021.SettingPaired NPS and BG-based saliva specimens collected from COVID-19 patients and healthy individuals were analyzed using NPS-RT-PCR, BG-RT-PCR, and BG-Ag-RDTs.ParticipantsThe study comprised 102 COVID-19-positive patients hospitalized after governmental screening process and 100 healthy individuals. Forty-five COVID-19 patients were sampled within 6 days of illness and 57 within 7–15 days; 27 were categorized as asymptomatic and 75, as symptomatic. Eight and 2 patients carried the SARS-CoV-2 Alpha and Delta variants, respectively.InterventionThe diagnostic performances of BG-Ag-RDT, BG-RT-PCR, and NPS-RT-PCR for detecting SARS-CoV-2 were compared.Main outcomesThe sensitivities of BG-Ag-RDT and BG-RT-PCR towards salivary viral detection were highly concordant, with no discrimination between symptomatic, asymptomatic, or SARS-CoV-2 variant cases.ResultsAmong total participants (mean age, 43.7 years), 51% were women. BG-Ag-RDTs showed high sensitivity (97.8%, [95% CI, 88.4% to 99.6%]) and specificity (100%, [95% CI, 96.3% to 100%) in 45 patients within 6 days of illness and could detect all cases of SARS-CoV-2 Alpha and Delta variants. In 11 asymptomatic early-stage cases, both BG-Ag-RDTs and BG-RT-PCR showed excellent sensitivity and specificity of 100% (95% CI, 74.1% to 100% and 95% CI, 20.7% to 100%, respectively). The interaction between SARS-CoV-2 spike proteins and truncated canavalin, an active ingredient from bean extract (BE) and the ultrastructural features of SARS-CoV-2 particles coated with BE were observed. The detachment of the SARS-CoV-2 receptor-binding domain from hACE2 increased as the BE concentration increased, allowing the release of the virus from hACE2 for early diagnosis.Conclusions and RelevanceUsing BG-based saliva remarkably enhances the Ag-RDT diagnostic performance as an alternative to NPS and enables rapid and accurate COVID-19 self-testing and mass screening, supporting efficient COVID-19 management.Trial RegistrationKCT0006438Key PointsQuestionHow can we collect SARS-CoV-2 from oral cavity to improve the sensitivity of antigen-based rapid diagnostic test (Ag-RDT)?FindingsIn this clinical study involving 102 hospitalized COVID-19 patients, the Ag-RDT test using Beanguard gargle™-based saliva specimens showed significantly enhanced sensitivity and specificity towards detection of SARS-CoV-2 along with Alpha and Delta variants in all patients tested within 6 days of illness.MeaningOur self-testing method represents an attractive alternative to nasopharyngeal swab RT-PCR for the early diagnosis of symptomatic and asymptomatic COVID-19 cases.
Published: 2021

22. Vessel Image Enhancement Method Using Nonlinear Transformation Based on Guided Filtering

Author: Tang Qi, Zhou Ke-xin, Sun Yi-xuan, and Wang Wen-tian
Subjects: business.industry, Computer science, Quantitative Biology::Tissues and Organs, media_common.quotation_subject, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, HSL and HSV, Image (mathematics), RGB color space, Nonlinear system, Computer Science::Computer Vision and Pattern Recognition, Component (UML), Preprocessor, Contrast (vision), Computer vision, Artificial intelligence, business, Laplace operator, media_common
Abstract: Aiming at the problems of blurred contrast and difficult diagnosis of vascular tissue in medical images, A nonlinear transform blood vessel enhancement method based on guided filtering is proposed. In this paper, a hybrid filter is obtained by fusing guided filtering and Laplacian filtering to complete the preprocessing of image vessel detail enhancement, then the green component is stretched by nonlinear mapping function in RGB color space, the red component and blue component are adjusted according to the stretching degree. Finally, the saturation component is nonlinear contrast stretched in HSV color space to achieve vascular image enhancement. The paper uses objective evaluation methods such as image DV-BV, information entropy and average gradient to compare the performance of existing image enhancement algorithms. The results show that the proposed method has excellent performance.
Published: 2021

23. Metabolism and transporter based drug–drug interaction of tacrolimus with nine co-medicated injections

Author: Sun Yi, Ting Wang, Qing Xu, Li Guodong, Hao Zhubing, Hu Zhuohan, Wei Wu, Yu Feifei, and Qianzhou Lv
Subjects: medicine.medical_specialty, Transporter base DDI, Drug–drug interaction (DDI), Pharmacology, Organ transplantation, Tacrolimus, Pharmacy and materia medica, Drug Discovery, medicine, Pharmacology (medical), Metabolism base DDI, IC50, Pantoprazole, CYP3A4, biology, Herb–drug interaction (HDI), business.industry, Cytochrome P450, Solute carrier family, RS1-441, surgical procedures, operative, Methylprednisolone, biology.protein, business, medicine.drug
Abstract: Background Tacrolimus, also named FK506, is a well-known potent immunosuppressant agent, which is usually co-medicated with multiple drugs in solid organ transplant. The objective of this study was to evaluate DDI between tacrolimus and nine injections co-administered in patients receiving liver organ transplant. Methods In this study, the cytochrome P450 enzymes (CYPs) inhibition assay were conducted by using pooled human liver microsomes, for supporting the evaluation of metabolism-mediated DDI. The transport substrate assay used to determine the transporter-mediated DDI, was conducted in the transfected HEK293 cell line expressing specific human transport proteins. Results All the tested drugs, especially alprostadil, methylprednisolone, and pantoprazole showed apparent inhibition on CYP3A4/5 with the half-maximal inhibitory concentration (IC50) from >0.5 μg/mL to 89.6 μg/mL, which also inhibited metabolism of tacrolimus in human liver microsomes, whose half time (T1/2) was prolonged from 5.04 to 35.3 min. However, tacrolimus was not the substrates of solute carrier (SLC) transporters including OATP1B1, OATP1B3, OAT1, OAT3, and OCT2, which indicated that the risk of transport-mediated DDI between tacrolimus and these nine drugs was likely to be low. Conclusions These findings indicate that the metabolism-based DDI between tacrolimus and co-administered nine drugs seems to be the major cause of the high individual variability of tacrolimus exposure in patients with solid organ transplant and should be further studied.
Published: 2021

24. The Effects of Hairstyling Service Marketing Mix on Customer Loyalty

Author: Sun Yi Park, Na Kyum Lee, and Chae Lim Kim
Subjects: Service (business), Business, Marketing, Marketing mix, Loyalty business model
Published: 2019

25. Comparison of vaginal hysterectomy and laparoscopic hysterectomy: a systematic review and meta-analysis

Author: Jung Woo Park, Jeong Hye Yun, So Ra Oh, Su Jin Kim, Jong Woon Bae, Sun Yi Choe, Joong Sub Choi, Myoungseok Han, Seung Hyun Lee, and Yeon Jean Cho
Subjects: Laparoscopic hysterectomy, medicine.medical_specialty, medicine.medical_treatment, Operative Time, Reproductive medicine, MEDLINE, Cochrane Library, Hysterectomy, Vaginal hysterectomy, lcsh:Gynecology and obstetrics, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Blood loss, Hysterectomy, Vaginal, medicine, Humans, 030212 general & internal medicine, lcsh:RG1-991, Pain, Postoperative, 030219 obstetrics & reproductive medicine, business.industry, lcsh:Public aspects of medicine, Obstetrics and Gynecology, lcsh:RA1-1270, General Medicine, Length of Stay, Surgery, Meta-analysis, Reproductive Medicine, Gynecology, Hysterectomy vaginal, Female, Laparoscopy, business, Research Article
Abstract: Background There are various surgical approaches of hysterectomy for benign indications. This study aimed to compare vaginal hysterectomy (VH) and laparoscopic hysterectomy (LH) with respect to their complications and operative outcomes. Methods We selected randomised controlled trials that compared VH with LH for benign gynaecological indications. We included studies published after January 2000 in the following databases: Medline, EMBASE, and CENTRAL (The Cochrane Library). The primary outcome was comparison of the complication rate. The secondary outcomes were comparisons of operating time, blood loss, intraoperative conversion, postoperative pain, length of hospital stay and duration of recuperation. We used Review Manager 5.3 software to perform the meta-analysis. Results Eighteen studies of 1618 patients met the inclusion criteria. The meta-analysis showed no differences in overall complications, intraoperative conversion, postoperative pain on the day of surgery and at 48 h, length of hospital stay and recuperation time between VH and LH. VH was associated with a shorter operating time and lower postoperative pain at 24 h than LH. Conclusions When both surgical approaches are feasible, VH should remain the surgery of choice for benign hysterectomy. Electronic supplementary material The online version of this article (10.1186/s12905-019-0784-4) contains supplementary material, which is available to authorized users.
Published: 2019

26. Long-term performance of the IGRA to predict and prevent active tuberculosis development in HIV-infected patients

Author: Junewoo Lee, Sun-Yi Lee, Sun-Gu Lee, Su-Hun Lee, and Junho Kang
Subjects: Adult, Male, 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 030106 microbiology, Antitubercular Agents, HIV Infections, Sensitivity and Specificity, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Ltbi treatment, Tuberculosis diagnosis, Latent Tuberculosis, Internal medicine, Positive predicative value, Republic of Korea, medicine, Humans, Tuberculosis, Hiv infected patients, 030212 general & internal medicine, Retrospective Studies, business.industry, Incidence, Incidence (epidemiology), Retrospective cohort study, Middle Aged, Active tuberculosis, Infectious Diseases, Female, business, Interferon-gamma Release Tests, Cohort study
Abstract: OBJECTIVE To estimate the long-term performance of the interferon-gamma release assay (IGRA) in predicting active tuberculosis (ATB) development among human immunodeficiency virus (HIV) infected patients in an intermediate TB burden country. DESIGN A retrospective cohort study was conducted. HIV-infected patients with 1 IGRA result but no current or previous ATB who had been retained in care for 1 year were enrolled and observed for ATB development from 2006 to 2016. RESULTS Sixty-two IGRA-positive and 354 IGRA-negative patients were observed for a median period of 4.03 years. ATB incidence in IGRA-positive vs. negative patients was respectively 15.24/1000 person-years (py) (95%CI 4.15-39.02) vs. 0.67/1000 py (95%CI 0.01-3.68) (P = 0.001). The sensitivity, specificity and positive and negative predictive values of the IGRA were respectively 80.0% (28.4-99.5%), 85.9% (82.1-89.1%), 6.5% (4.0-10.2%) and 99.7% (98.4-99.9%). Among the 62 IGRA-positive patients, 25 were treated for latent tuberculous infection (LTBI) and 37 were not. Patients with LTBI treatment did not develop ATB, while four cases of ATB occurred among patients without LTBI treatment. Among the 257 IGRA-negative patients who received a follow-up IGRA, 34 (12.9%) patients converted to positive. No ATB developed in IGRA converters. CONCLUSION Screening for LTBI using IGRAs and LTBI treatment can be useful to prevent ATB in an intermediate TB burden country. .
Published: 2019

27. A study on Design for the Commercialization of Traditional Hairstyles in the Joseon Dynasty

Author: Mi Ock Woo and Sun Yi Park
Subjects: Engineering, Economy, business.industry, General Medicine, business, Commercialization
Published: 2019

28. Effects of EGR and combustion phasing on the combustion and emission characteristic of direct-injection CI engine fueled with n-butanol/diesel blends

Author: Qiao Wang, Hao Zhang, Liang Guo, Wanchen Sun, Peng Cheng, Sun Yi, and Fan Luyan
Subjects: Thermal efficiency, business.industry, 020209 energy, Butanol, 02 engineering and technology, Combustion, law.invention, Ignition system, Diesel fuel, chemistry.chemical_compound, 020401 chemical engineering, chemistry, n-Butanol, law, Biofuel, 0202 electrical engineering, electronic engineering, information engineering, Environmental science, 0204 chemical engineering, Process engineering, business, NOx
Abstract: Shortage of fossil fuel and stringent emission regulations require less pollutant emissions and better fuel conversion efficiency from modern internal combustion (IC) engines. Butanol is of particular interest as a renewable biofuel for advanced compression ignition (CI) engines, which has been receiving widely researches consequently. In order to more comprehensively evaluate the application of butanol on modern CI engine, exploration strategy was focused on the combining of EGR and combustion phasing control to achieve ultra-low NOx and smoke emission without penalty on fuel economy. Experiment was conducted under constant engine speed and both the high and low engine load conditions with three volume fractions of butanol up to 30%. Results indicate that butanol blending causes extended ignition delay, increased premixed combustion ratio (PCR) and retarded combustion phasing, which is more significant at low load condition. Butanol/diesel blends can dramatically reduce exhaust smoke and particle emissions without increasing NOx emissions at, however, the expense of lower thermal efficiency than that of pure diesel. Reduced thermal efficiency can be recovered by properly matching EGR and combustion phasing under a low level of overall emission.
Published: 2019

29. Migration impact on China’s population dividing line driven by hybrid features: perspectives of climate change and wage gap

Author: Xu Chengjin, Sun Yi, Liu Changxin, Wang Zheng, Zhang Hailing, and Ding Guanqun
Subjects: Computable general equilibrium, education.field_of_study, Renewable Energy, Sustainability and the Environment, business.industry, media_common.quotation_subject, Economics, Econometrics and Finance (miscellaneous), Population, Wage, Distribution (economics), Development, Per capita income, Gross domestic product, Urban Studies, Geography, Demographic economics, Remittance, education, China, business, media_common
Abstract: The development of China’s population distribution boundary (Hu Line) in the future will have mixed driving characteristics: (1) driven by potential agricultural production in the long term; (2) driven by the wage gap between the eastern and the western provinces in the short term. At the same time, China’s unique pattern of migrant workers has increased the complexity of the issue of population migration between the Hu Line. This paper establishes a population support model based on the Potential Agricultural Production and a multi-regional Computable general equilibrium model considering a transfer mechanism of remittance. Results show that the population proportion caused by climate change in the provinces west of the Hu Line will increase in the long term, but the stability of the Hu Line has not been broken down. In the short term, as the wage-driven migration of western labor force expands, the country’s total economy shows a growing trend, and the wage gap between regions gradually narrows with the expansion of the migration scale. When the migration rate of the western labor force is 30%, the per capita GDP gap between the eastern and western regions of the Hu Line is the minimum, and when the rate is 10%, the per capita income gap between the eastern and western regions is the smallest. Though the rural migrant workers from the western province can improve the living standards of families in the western regions, it has little impact on the national and regional economy overall.
Published: 2019

30. Computer Vision for Vulnerable Road Users using Machine Learning

Author: Devi Chilukuri, Younho Seong, and Sun Yi
Subjects: business.industry, Computer science, Deep learning, Tracking system, Machine learning, computer.software_genre, Data type, Hough transform, law.invention, Software, law, Global Positioning System, Artificial intelligence, Android (operating system), Transfer of learning, business, computer
Abstract: Transportation has become a very important component for all ages in today’s life. However, seniors often find difficulty in travelling by public transport or even by their own vehicles. Thus, they are considered as Vulnerable Road Users (VRUs). This research mainly concentrates on creating an application that helps the elderly mobile users in virtually screening of directions using GPS, tracking of sidewalks, identifying the traffic signals and other sign boards. MATLAB/Simulink serves as the main software used in developing this application. Images and other types of data are captured using sensors on Android devices. Then MATLAB is used to perform deep learning. Transfer learning is another machine learning technique where a model like AlexNet developed for one task is retrained to perform a second task. In this research, AlexNet is used to identify and classify different traffic warning signs in real-time. A detailed description of this method and the results are presented in this paper. Once the MATLAB-based program is developed, it can be converted into Java codes when needed. Using Android Studio, the code can be used in the application. VRUs with mobility impairments and vision deficiencies often find it difficult to use wheelchair on sidewalks. This paper also presents a sidewalk tracking system with a departure warning. In this research, Hough Transform is used to present the detection of sidewalk. This sidewalk tracking system can provide the user with essential information that can minimize the risk of an accident. This system can identify and track the present sidewalks. Any unintended departure towards the edge of sidewalks will be detected and notified to the user. Elaborated implementation of this system and results are presented in this paper. Re-routing the user when they approach the end of the sidewalk is left for future work. The application will further be developed to provide a voice navigation informing the departure warning, a traffic signal or a recognized sign board.
Published: 2019

31. Precision test technology of liquid refractive index using the method of minimum deviation angle

Author: 孙一书 Sun Yi-shu, 陈怡 Chen Yi, 韩冰 Han Bing, and 袁理 Yuan Li
Subjects: Optics, business.industry, Minimum deviation, business, Refractive index, Atomic and Molecular Physics, and Optics, Mathematics, Test (assessment)
Published: 2019

32. Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague–Dawley rats

Author: Jong Kwon Lee, Ki Sook Park, Eun Ji Kim, Nam Hee Youn, Ki Taek Nam, Jung-Sun Yi, Yejin Cho, and Joo Hwan Kim
Subjects: Drug, business.industry, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Radiation dose, Ultraviolet a, 010501 environmental sciences, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, 01 natural sciences, Phototoxicity Study, 03 medical and health sciences, 0302 clinical medicine, In vivo, Sprague dawley rats, Medicine, Original Article, Phototoxicity, business, 0105 earth and related environmental sciences, media_common, Skin Findings
Abstract: In vivo phototoxicity testing is important for predicting drug-induced phototoxicity in humans. Currently, there is no internationally validated in vivo test method for the photosafety evaluation of pharmaceuticals. In this study, we evaluated the phototoxicity of systemically administered drugs using SD rats. We first determined the appropriate ultraviolet A (UVA) dose using 8-methoxypsoralen, a well-known phototoxic drug. Compared to lower and higher UVA doses, we found that a UVA dose of 10 J/cm(2) allowed for the detection of phototoxic responses in both a dose- and time-dependent manner. We next performed a phototoxicity study using seven pharmaceutical drugs which included known phototoxic and non-phototoxic drugs using a UVA dose of 10 J/cm(2). In order to improve the accuracy of our assessment, we evaluated both gross skin findings as well as histopathological findings. Using gross skin findings alone resulted in an accuracy of 85.7% which could be increased to 100% accuracy when the gross skin findings were combined with histopathological findings. This study suggests that the inclusion of histopathological findings increases the accuracy of the phototoxicity evaluation of systemically administered drugs in SD rats. In conclusion, we found that for studying drug-induced phytotoxicity, a 10 J/cm(2) UVA dose serves as the optimal radiation dose, and that the inclusion of histopathological findings increases the accuracy of the phototoxicity evaluation of the drugs.
Published: 2021

33. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Author: Klionsky, Daniel, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis, Adeli, Khosrow, Adolph, Timon, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed, Agrotis, Alexander, Aguilar, Patricia, Ahmad, S Tariq, Ahmed, Zubair, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo, Altan-Bonnet, Nihal, Altieri, Dario, Álvarez, Élida, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal, Ammanathan, Veena, An, Zhenyi, Andersen, Stig, Andrabi, Shaida, Andrade-Silva, Magaiver, Andres, Allen, Angelini, Sabrina, Ann, David, Anozie, Uche, Ansari, Mohammad, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas, Au, Alicia, Auberger, Patrick, Auner, Holger, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan, Backues, Steven, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter, Barmada, Sami, Barreiro, Esther, Barreto, George, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav, Basagoudanavar, Suresh, Bassham, Diane, Bast, Robert, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne, Baumgarner, Bradley, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz, Beck, George, Beers, Michael, Begun, Jakob, Behrends, Christian, Behrens, Georg, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares de Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri, Besteiro, Sebastien, Betin, Virginie, Beyaert, Rudi, Bezbradica, Jelena, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor, Bijian, Krikor, Billes, Viktor, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa, Bjorkoy, Geir, Blanco, Gonzalo, Blas-Garcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice, Boada-Romero, Emilio, Boban, Mirta, Boesze-Battaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan, Boone, Brian, Bootman, Martin, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat, Borthakur, Gautam, Bosch, Jürgen, Bose, Santanu, botana, luis, Botas, Juan, Boulanger, Chantal, Boulton, Michael, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter, Bozi, Luiz, Bozkurt, Tolga, Brackney, Doug, Brandts, Christian, Braun, Ralf, Braus, Gerhard, Bravo-Sagua, Roberto, Bravo-San Pedro, José, Brest, Patrick, Bringer, Marie-Agnès, Briones-Herrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Brodsky, Jeffrey, Brody, Steven, Bronson, Paola, Bronstein, Jeff, Brown, Carolyn, Brown, Rhoderick, Brum, Patricia, Brumell, John, Brunetti-Pierri, Nicola, Bruno, Daniele, Bryson-Richardson, Robert, Bucci, Cecilia, Buchrieser, Carmen, Bueno, Marta, Buitrago-Molina, Laura Elisa, Buraschi, Simone, Buch, Shilpa, Buchan, J Ross, Buckingham, Erin, Budak, Hikmet, Budini, Mauricio, Bultynck, Geert, Burada, Florin, Burgoyne, Joseph, Burón, M Isabel, Bustos, Victor, Büttner, Sabrina, Butturini, Elena, Byrd, Aaron, Cabas, Isabel, Cabrera-Benitez, Sandra, Cadwell, Ken, Cai, Jingjing, Cai, Lu, Cai, Qian, Cairó, Montserrat, Calbet, Jose, Caldwell, Guy, Caldwell, Kim, Call, Jarrod, Calvani, Riccardo, Calvo, Ana, Calvo-Rubio Barrera, Miguel, Camara, Niels OS, Camonis, Jacques, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Edward, Campbell-Valois, François-Xavier, Campello, Silvia, Campesi, Ilaria, Campos, Juliane, Camuzard, Olivier, Cancino, Jorge, Candido de Almeida, Danilo, Canesi, Laura, Caniggia, Isabella, Canonico, Barbara, Cantí, Carles, Cao, Bin, Caraglia, Michele, Caramés, Beatriz, Carchman, Evie, Cardenal-Muñoz, Elena, Cardenas, Cesar, Cardenas, Luis, Cardoso, Sandra, Carew, Jennifer, Carle, Georges, Carleton, Gillian, Carloni, Silvia, Carmona-Gutierrez, Didac, Carneiro, Leticia, Carnevali, Oliana, Carosi, Julian, Carra, Serena, Carrier, Alice, Carrier, Lucie, Carroll, Bernadette, Carter, A Brent, Carvalho, Andreia Neves, Casanova, Magali, Casas, Caty, Casas, Josefina, Cassioli, Chiara, Castillo, Eliseo, Castillo, Karen, Castillo-Lluva, Sonia, Castoldi, Francesca, Castori, Marco, Castro, Ariel, Castro-Caldas, Margarida, Castro-Hernandez, Javier, Castro-Obregon, Susana, Catz, Sergio, Cavadas, Claudia, Cavaliere, Federica, Cavallini, Gabriella, Cavinato, Maria, Cayuela, Maria, Cebollada Rica, Paula, Cecarini, Valentina, Cecconi, Francesco, Cechowska-Pasko, Marzanna, Cenci, Simone, Ceperuelo-Mallafré, Victòria, Cerqueira, João, Cerutti, Janete, Cervia, Davide, Cetintas, Vildan Bozok, Cetrullo, Silvia, Chae, Han-Jung, Chagin, Andrei, Chai, Chee-Yin, Chakrabarti, Gopal, Chakrabarti, Oishee, Chakraborty, Tapas, Chakraborty, Trinad, Chami, mounia, Chamilos, Georgios, Chan, David, Chan, Edmond, Chan, Edward, Chan, H.Y. Edwin, Chan, Helen, Chan, Hung, Chan, Matthew, Chan, Yau Sang, Chandra, Partha, Chang, Chih-Peng, Chang, Chunmei, Chang, Hao-Chun, Chang, Kai, Chao, Jie, Chapman, Tracey, Charlet-Berguerand, Nicolas, Chatterjee, Samrat, Chaube, Shail, Chaudhary, Anu, Chauhan, Santosh, Chaum, Edward, Checler, Frédéric, Cheetham, Michael, Chen, Chang-Shi, Chen, Guang-Chao, Chen, Jian-Fu, Chen, Liam, Chen, Leilei, Chen, Lin, Chen, Mingliang, Chen, Mu-Kuan, Chen, Ning, Chen, Quan, Chen, Ruey-Hwa, Chen, Shi, Chen, Wei, Chen, Weiqiang, Chen, Xin-Ming, Chen, Xiong-Wen, Chen, Xu, Chen, Yan, Chen, Ye-Guang, Chen, Yingyu, Chen, Yongqiang, Chen, Yu-Jen, Chen, Yue-Qin, Chen, Zhefan Stephen, Chen, Zhi, Chen, Zhi-Hua, Chen, Zhijian, Chen, Zhixiang, Cheng, Hanhua, Cheng, Jun, Cheng, Shi-Yuan, Cheng, Wei, Cheng, Xiaodong, Cheng, Xiu-Tang, Cheng, Yiyun, Cheng, Zhiyong, Chen, Zhong, Cheong, Heesun, Cheong, Jit Kong, Chernyak, Boris, Cherry, Sara, Cheung, Chi Fai Randy, Cheung, Chun Hei Antonio, Cheung, King-Ho, Chevet, Eric, Chi, Richard, Chiang, Alan Kwok Shing, Chiaradonna, Ferdinando, Chiarelli, Roberto, Chiariello, Mario, Chica, Nathalia, Chiocca, Susanna, Chiong, Mario, Chiou, Shih-Hwa, Chiramel, Abhilash, Chiurchiù, Valerio, Cho, Dong-Hyung, Choe, Seong-Kyu, Choi, Augustine, Choi, Mary, Choudhury, Kamalika Roy, Chow, Norman, Chu, Charleen, Chua, Jason, Chua, John Jia En, Chung, Hyewon, Chung, Kin Pan, Chung, Seockhoon, Chung, So-Hyang, Chung, Yuen-Li, Cianfanelli, Valentina, Ciechomska, Iwona, Cifuentes, Mariana, Cinque, Laura, Cirak, Sebahattin, Cirone, Mara, Clague, Michael, Clarke, Robert, Clementi, Emilio, Coccia, Eliana, Codogno, Patrice, Cohen, Ehud, Cohen, Mickael, Colasanti, Tania, Colasuonno, Fiorella, Colbert, Robert, Colell, Anna, Čolić, Miodrag, Coll, Nuria, Collins, Mark, Colombo, María, Colón-Ramos, Daniel, Combaret, Lydie, Comincini, Sergio, Cominetti, Márcia, Consiglio, Antonella, Conte, Andrea, Conti, Fabrizio, Contu, Viorica Raluca, Cookson, Mark, Coombs, Kevin, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corkery, Dale, Cordes, Nils, Cortese, Katia, Costa, Maria do Carmo, Costantino, Sarah, Costelli, Paola, Coto-Montes, Ana, Crack, Peter, Crespo, Jose, Criollo, Alfredo, Crippa, Valeria, Cristofani, Riccardo, Csizmadia, Tamas, Cuadrado, Antonio, Cui, Bing, Cui, Jun, Cui, Yixian, Cui, Yong, Culetto, Emmanuel, Cumino, Andrea, Cybulsky, Andrey, Czaja, Mark, Czuczwar, Stanislaw, D'Adamo, Stefania, D'Amelio, Marcello, D'Arcangelo, Daniela, D'Lugos, Andrew, D'Orazi, Gabriella, da Silva, James, Dafsari, Hormos Salimi, Dagda, Ruben, Dagdas, Yasin, Daglia, Maria, Dai, Xiaoxia, Dai, Yun, Dai, Yuyuan, Dal Col, Jessica, Dalhaimer, Paul, Dalla Valle, Luisa, Dallenga, Tobias, Dalmasso, Guillaume, Damme, Markus, Dando, Ilaria, Dantuma, Nico, Darling, April, Das, Hiranmoy, Dasarathy, Srinivasan, Dasari, Santosh, Dash, Srikanta, Daumke, Oliver, Dauphinee, Adrian, Davies, Jeffrey, Dávila, Valeria, Davis, Roger, Davis, Tanja, Dayalan Naidu, Sharadha, De Amicis, Francesca, De Bosscher, Karolien, De Felice, Francesca, De Franceschi, Lucia, De Leonibus, Chiara, de Mattos Barbosa, Mayara, De Meyer, Guido, De Milito, Angelo, De Nunzio, Cosimo, De Palma, Clara, De Santi, Mauro, De Virgilio, Claudio, De Zio, Daniela, Debnath, Jayanta, DeBosch, Brian, Decuypere, Jean-Paul, Deehan, Mark, Deflorian, Gianluca, DeGregori, James, Dehay, Benjamin, Del Rio, Gabriel, Delaney, Joe, Delbridge, Lea, Delorme-Axford, Elizabeth, Delpino, M Victoria, Demarchi, Francesca, Dembitz, Vilma, Demers, Nicholas, Deng, Hongbin, Deng, Zhiqiang, Dengjel, Joern, Dent, Paul, Denton, Donna, DePamphilis, Melvin, Der, Channing, Deretic, Vojo, Descoteaux, Albert, Devis, Laura, Devkota, Sushil, Devuyst, Olivier, Dewson, Grant, Dharmasivam, Mahendiran, Dhiman, Rohan, di Bernardo, Diego, Di Cristina, Manlio, Di Domenico, Fabio, Di Fazio, Pietro, Di Fonzo, Alessio, Di Guardo, Giovanni, Di Guglielmo, Gianni, Di Leo, Luca, Di Malta, Chiara, Di Nardo, Alessia, Di Rienzo, Martina, Di Sano, Federica, Diallinas, George, Diao, Jiajie, Diaz-Araya, Guillermo, Díaz-Laviada, Inés, Dickinson, Jared, Diederich, Marc, Dieudé, Mélanie, Dikic, Ivan, Ding, Shiping, Ding, Wen-Xing, Dini, Luciana, Dinić, Jelena, Dinic, Miroslav, Dinkova-Kostova, Albena, Dionne, Marc, Distler, Jörg, Diwan, Abhinav, Dixon, Ian, Djavaheri-Mergny, Mojgan, Dobrinski, Ina, Dobrovinskaya, Oxana, Dobrowolski, Radek, Dobson, Renwick, Đokić, Jelena, Dokmeci Emre, Serap, Donadelli, Massimo, Dong, Bo, Dong, Xiaonan, Dong, Zhiwu, Dorn Ii, Gerald, Dotsch, Volker, Dou, Huan, Dou, Juan, Dowaidar, Moataz, Dridi, Sami, Drucker, Liat, Du, Ailian, Du, Caigan, Du, Guangwei, Du, Hai-Ning, Du, Li-Lin, du Toit, André, Duan, Shao-Bin, Duan, Xiaoqiong, Duarte, Sónia, Dubrovska, Anna, Dunlop, Elaine, Dupont, Nicolas, Durán, Raúl, Dwarakanath, Bilikere, Dyshlovoy, Sergey, Ebrahimi-Fakhari, Darius, Eckhart, Leopold, Edelstein, Charles, Efferth, Thomas, Eftekharpour, Eftekhar, Eichinger, Ludwig, Eid, Nabil, Eisenberg, Tobias, Eissa, N Tony, Eissa, Sanaa, Ejarque, Miriam, El Andaloussi, Abdeljabar, El-Hage, Nazira, El-Naggar, Shahenda, Eleuteri, Anna Maria, El-Shafey, Eman, Elgendy, Mohamed, Eliopoulos, Aristides, Elizalde, María, Elks, Philip, Elsasser, Hans-Peter, Elsherbiny, Eslam, Emerling, Brooke, Emre, N., Eng, Christina, Engedal, Nikolai, Engelbrecht, Anna-Mart, Engelsen, Agnete, Enserink, Jorrit, Escalante, Ricardo, Esclatine, Audrey, Escobar-Henriques, Mafalda, Eskelinen, Eeva-Liisa, Espert, Lucile, Eusebio, Makandjou-Ola, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Facchiano, Francesco, Fadeel, Bengt, Fader, Claudio, Faesen, Alex, Fairlie, W Douglas, Falcó, Alberto, Falkenburger, Bjorn, Fan, Daping, Fan, Jie, Fan, Yanbo, Fang, Evandro, Fang, Yanshan, Fang, Yognqi, Fanto, Manolis, Farfel-Becker, Tamar, Faure, Mathias, Fazeli, Gholamreza, Fedele, Anthony, Feldman, Arthur, Feng, Du, Feng, Jiachun, Feng, Lifeng, Feng, Yibin, Feng, Yuchen, Feng, Wei, Fenz Araujo, Thais, Ferguson, Thomas, 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Sachith, Galluzzi, Lorenzo, Galy, Vincent, Gammoh, Noor, Gan, Boyi, Ganley, Ian, Gao, Feng, Gao, Hui, Gao, Minghui, Gao, Ping, Gao, Shou-Jiang, Gao, Wentao, Gao, Xiaobo, Garcera, Ana, Garcia, Maria Noé, Garcia, Verónica, García-del Portillo, Francisco, Garcia-Escudero, Vega, Garcia-Garcia, Aracely, Garcia-Macia, Marina, García-Moreno, Diana, Garcia-Ruiz, Carmen, García-Sanz, Patricia, Garg, Abhishek, Gargini, Ricardo, Garofalo, Tina, Garry, Robert, Gassen, Nils, Gatica, Damian, Ge, Liang, Ge, Wanzhong, Geiss-Friedlander, Ruth, Gelfi, Cecilia, Genschik, Pascal, Gentle, Ian, Gerbino, Valeria, Gerhardt, Christoph, Germain, Kyla, Germain, Marc, Gewirtz, David, Ghasemipour Afshar, Elham, Ghavami, Saeid, Ghigo, Alessandra, Ghosh, Manosij, Giamas, Georgios, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibson, Gary, Gibson, Spencer, Ginet, Vanessa, Giniger, Edward, Giorgi, Carlotta, Girao, Henrique, Girardin, Stephen, Giridharan, Mridhula, Giuliano, Sandy, Giulivi, Cecilia, Giuriato, 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Anna, Hernández, Agustín, Hernandez, Carlos, Hernandez-Diaz, Sergio, Hernandez-Gea, Virginia, Herpin, Amaury, Herreros, Judit, Hervás, Javier, Hesselson, Daniel, Hetz, Claudio, Heussler, Volker, Higuchi, Yujiro, Hilfiker, Sabine, Hill, Joseph, Hlavacek, William, Ho, Emmanuel, Ho, Idy, Ho, Philip Wing-Lok, Ho, Shu-Leong, Ho, Wan Yun, Hobbs, G Aaron, Hochstrasser, Mark, Hoet, Peter, Hofius, Daniel, Hofman, Paul, Höhn, Annika, Holmberg, Carina, Hombrebueno, Jose, Yi-Ren Hong, Chang-Won Hong, Hooper, Lora, Hoppe, Thorsten, Horos, Rastislav, Hoshida, Yujin, Hsin, I-Lun, Hsu, Hsin-Yun, Hu, Bing, Hu, Dong, Hu, Li-Fang, Hu, Ming Chang, Hu, Ronggui, Hu, Wei, Hu, Yu-Chen, Hu, Zhuo-Wei, Hua, Fang, Hua, Jinlian, Hua, Yingqi, Huan, Chongmin, Huang, Canhua, Huang, Chuanshu, Huang, Chuanxin, Huang, Chunling, Huang, Haishan, Huang, Kun, Huang, Michael, Huang, Rui, Huang, Shan, Huang, Tianzhi, Huang, Xing, Huang, Yuxiang Jack, Huber, Tobias, Hubert, Virginie, Hubner, Christian, Hughes, Stephanie, 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Chengyu, Liang, Qiangrong, Liang, Weicheng, Liang, Yongheng, Liang, YongTian, Liao, Guanghong, Liao, Lujian, Liao, Mingzhi, Liao, Yung-Feng, Librizzi, Mariangela, Lie, Pearl, Lilly, Mary, Lim, Hyunjung, Lima, Thania, Limana, Federica, Lin, Chao, Lin, Chih-Wen, Lin, Dar-Shong, Lin, Fu-Cheng, Lin, Jiandie, Lin, Kurt, Lin, Kwang-Huei, Lin, Liang-Tzung, LIN, Pei-Hui, Lin, Qiong, Lin, Shaofeng, Lin, Su-Ju, Lin, Wenyu, Lin, Xueying, Lin, Yao-Xin, Lin, Yee-Shin, Linden, Rafael, Lindner, Paula, Ling, Shuo-Chien, Lingor, Paul, Linnemann, Amelia, Liou, Yih-Cherng, Lipinski, Marta, Lipovšek, Saška, Lira, Vitor, Lisiak, Natalia, Liton, Paloma, Liu, Chao, Liu, Ching-Hsuan, Liu, Chun-Feng, Liu, Cui Hua, Liu, Fang, Liu, Hao, Liu, Hsiao-Sheng, Liu, Hua-feng, Liu, Huifang, Liu, Jia, Liu, Jing, Liu, Julia, Liu, Leyuan, Liu, Longhua, Liu, Meilian, Liu, Qin, Liu, Wei, Liu, Wende, Liu, Xiao-Hong, Liu, Xiaodong, Liu, Xingguo, Liu, Xu, Liu, Xuedong, Liu, Yanfen, Liu, Yang, Liu, Yueyang, Liu, Yule, 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Celeste, O’Donovan, Tracey, O’Leary, Seónadh, O’Rourke, Eyleen, O’Sullivan, Mary, O’Sullivan, Timothy, Omary, M. Bishr, Pereira, Gustavo J.S., Ratnayaka, J. Arjuna, Riazuddin, S. Amer, Rouschop, Kasper M.A., Sanderson, J. Thomas, Scaglione, K. Matthew, Schapira, Anthony H.V., Scovassi, A. Ivana, St. Clair, Daret, Sunahara, Karen K.S., Symons, J. David, Triola, Gemma, van Wijk, Sjoerd J.L., Vanrell, M. Cristina, Vasconcelos, M. Helena, Whitton, J. Lindsay, Williams, Robin S.B., Wong, W. Wei-Lynn, Wu, William K.K., Yakhine-Diop, Sokhna M.S., Yu, W. Haung, Zhang, Kalin Y.B., Dong, X. Charlie, Ain Shams University [ASU], Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University [JGU], Medical University Graz, Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)], Institut Pasteur d'Iran, Leibniz Institute of Plant Biochemistry [IPB], The University of Texas M.D. Anderson Cancer Center [Houston], Institut de pharmacologie moléculaire et cellulaire [IPMC], Lipides - Nutrition - Cancer [Dijon - U1231] [LNC], Centre méditerranéen de médecine moléculaire [C3M], Institut de Biologie Valrose [IBV], Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Institut Cochin [IC UM3 (UMR 8104 / U1016)], Institut NeuroMyoGène [INMG], Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)], Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)], Institut de Recherche sur le Cancer et le Vieillissement [IRCAN], Centre de Recherche en Cancérologie de Marseille [CRCM], Centre for Integrative Biology - CBI [Inserm U964 - CNRS UMR7104 - IGBMC], Oncogenesis, Stress, Signaling [OSS], Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)], Institut de Biologie Intégrative de la Cellule [I2BC], Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH], Centre de Recherches en Cancérologie de Toulouse [CRCT], Physiopathologie et traitement des maladies du foie, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC], Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] [BIO-PEROXIL], Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)], Unité de génétique et biologie des cancers [U830], Laboratoire d'Optique et Biosciences [LOB], Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC], Différenciation et communication neuronale et neuroendocrine [DC2N], Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Centre d'Immunologie de Marseille - Luminy [CIML], Physiopathologie et imagerie des troubles neurologiques [PhIND], Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée [LBFA], Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163], Institut Mondor de Recherche Biomédicale [IMRB], Franco-czech Laboratory for clinical research on obesity, University of Michigan [Ann Arbor], University of Michigan System, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Institut de Biologie Valrose (IBV), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Nutrition, Métabolisme, Aquaculture (NuMéA), Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology-Centre National de la Recherche Scientifique (CNRS), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] (BIO-PEROXIL), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epithelial biology and disease - Liliane Bettencourt Chair of Developmental Biology (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Charles University [Prague]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the National Institute of General Medical Sciences [GM131919]., Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Département Plateforme (PF I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Chinese Academy of Medical Sciences [Suzhou, Chine] (CAMS), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Department of Women's and Children's Health [Stockholm, Sweden], Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Life Sciences Institute [Ann Arbor, MI, USA], University of Michigan System-University of Michigan System, European Institute of Oncology IRCCS [Milan, Italy] (EIO), Ain Shams University (ASU), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), Leibniz Institute of Plant Biochemistry (IPB), Hebrew University of Jerusalem, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Oncogenesis, Stress, Signaling (OSS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Charles University [Prague] (CU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., Adamopoulos, I. E., Adeli, K., Adolph, T. E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B. B., Agnello, M., Agostinis, P., Agrewala, J. N., Agrotis, A., Aguilar, P. V., Ahmad, S. T., Ahmed, Z. M., Ahumada-Castro, U., Aits, S., Aizawa, S., Akkoc, Y., Akoumianaki, T., Akpinar, H. A., Al-Abd, A. M., Al-Akra, L., Al-Gharaibeh, A., Alaoui-Jamali, M. A., Alberti, S., Alcocer-Gomez, E., Alessandri, C., Ali, M., Alim Al-Bari, M. A., Aliwaini, S., Alizadeh, J., Almacellas, E., Almasan, A., Alonso, A., Alonso, G. D., Altan-Bonnet, N., Altieri, D. C., Alvarez, E. M. C., Alves, S., Alves da Costa, C., Alzaharna, M. M., Amadio, M., Amantini, C., Amaral, C., Ambrosio, S., Amer, A. O., Ammanathan, V., An, Z., Andersen, S. U., Andrabi, S. A., Andrade-Silva, M., Andres, A. M., Angelini, S., Ann, D., Anozie, U. C., Ansari, M. 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T., Balduini, W., Ballabio, A., Ballester, M., Balazadeh, S., Balzan, R., Bandopadhyay, R., Banerjee, S., Banreti, A., Bao, Y., Baptista, M. S., Baracca, A., Barbati, C., Bargiela, A., Barila, D., Barlow, P. G., Barmada, S. J., Barreiro, E., Barreto, G. E., Bartek, J., Bartel, B., Bartolome, A., Barve, G. R., Basagoudanavar, S. H., Bassham, D. C., Bast, R. C., Basu, A., Batoko, H., Batten, I., Baulieu, E. E., Baumgarner, B. L., Bayry, J., Beale, R., Beau, I., Beaumatin, F., Bechara, L. R. G., Beck, G. R., Beers, M. F., Begun, J., Behrends, C., Behrens, G. M. N., Bei, R., Bejarano, E., Bel, S., Behl, C., Belaid, A., Belgareh-Touze, N., Bellarosa, C., Belleudi, F., Bello Perez, M., Bello-Morales, R., Beltran, J. S. D. O., Beltran, S., Benbrook, D. M., Bendorius, M., Benitez, B. A., Benito-Cuesta, I., Bensalem, J., Berchtold, M. W., Berezowska, S., Bergamaschi, D., Bergami, M., Bergmann, A., Berliocchi, L., Berlioz-Torrent, C., Bernard, A., Berthoux, L., Besirli, C. 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M., Villalobo, A., Villarejo-Zori, B., Villarroya, F., Villarroya, J., Vincent, O., Vindis, C., Viret, C., Viscomi, M. T., Visnjic, D., Vitale, I., Vocadlo, D. J., Voitsekhovskaja, O. V., Volonte, C., Volta, M., Vomero, M., Von Haefen, C., Vooijs, M. A., Voos, W., Vucicevic, L., Wade-Martins, R., Waguri, S., Waite, K. A., Wakatsuki, S., Walker, D. W., Walker, M. J., Walker, S. A., Walter, J., Wandosell, F. G., Wang, B., Wang, C. -Y., Wang, C., Wang, D., Wang, F., Wang, G., Wang, H., Wang, H. -G., Wang, J., Wang, K., Wang, L., Wang, M. H., Wang, M., Wang, N., Wang, P., Wang, Q. J., Wang, Q., Wang, Q. K., Wang, Q. A., Wang, W. -T., Wang, W., Wang, X., Wang, Y., Wang, Y. -Y., Wang, Z., Warnes, G., Warnsmann, V., Watada, H., Watanabe, E., Watchon, M., Wawrzynska, A., Weaver, T. E., Wegrzyn, G., Wehman, A. M., Wei, H., Wei, L., Wei, T., Wei, Y., Weiergraber, O. H., Weihl, C. C., Weindl, G., Weiskirchen, R., Wells, A., Wen, R. H., Wen, X., Werner, A., Weykopf, B., Wheatley, S. P., Whitton, J. L., Whitworth, A. J., Wiktorska, K., Wildenberg, M. E., Wileman, T., Wilkinson, S., Willbold, D., Williams, B., Williams, R. S. B., Williams, R. L., Williamson, P. R., Wilson, R. A., Winner, B., Winsor, N. J., Witkin, S. S., Wodrich, H., Woehlbier, U., Wollert, T., Wong, E., Wong, J. H., Wong, R. W., Wong, V. K. W., Wong, W. W. -L., Wu, A. -G., Wu, C., Wu, J., Wu, K. K., Wu, M., Wu, S. -Y., Wu, S., Wu, W. K. K., Wu, X., Wu, Y. -W., Wu, Y., Xavier, R. J., Xia, H., Xia, L., Xia, Z., Xiang, G., Xiang, J., Xiang, M., Xiang, W., Xiao, B., Xiao, G., Xiao, H., Xiao, H. -T., Xiao, J., Xiao, L., Xiao, S., Xiao, Y., Xie, B., Xie, C. -M., Xie, M., Xie, Y., Xie, Z., Xilouri, M., Xu, C., Xu, E., Xu, H., Xu, J., Xu, L., Xu, W. W., Xu, X., Xue, Y., Yakhine-Diop, S. M. S., Yamaguchi, M., Yamaguchi, O., Yamamoto, A., Yamashina, S., Yan, S., Yan, S. -J., Yan, Z., Yanagi, Y., Yang, C., Yang, D. -S., Yang, H., Yang, H. -T., Yang, J. -M., Yang, J., Yang, L., Yang, M., Yang, P. -M., Yang, Q., Yang, S., Yang, S. -F., Yang, W., Yang, W. Y., Yang, X., Yang, Y., Yao, H., Yao, S., Yao, X., Yao, Y. -G., Yao, Y. -M., Yasui, T., Yazdankhah, M., Yen, P. M., Yi, C., Yin, X. -M., Yin, Y., Yin, Z., Ying, M., Ying, Z., Yip, C. K., Yiu, S. P. T., Yoo, Y. H., Yoshida, K., Yoshii, S. R., Yoshimori, T., Yousefi, B., Yu, B., Yu, H., Yu, J., Yu, L., Yu, M. -L., Yu, S. -W., Yu, V. C., Yu, W. H., Yu, Z., Yuan, J., Yuan, L. -Q., Yuan, S., Yuan, S. -S. F., Yuan, Y., Yuan, Z., Yue, J., Yue, Z., Yun, J., Yung, R. L., Zacks, D. N., Zaffagnini, G., Zambelli, V. O., Zanella, I., Zang, Q. S., Zanivan, S., Zappavigna, S., Zaragoza, P., Zarbalis, K. S., Zarebkohan, A., Zarrouk, A., Zeitlin, S. O., Zeng, J., Zeng, J. -D., Zerovnik, E., Zhan, L., Zhang, B., Zhang, D. D., Zhang, H., Zhang, H. -L., Zhang, J., Zhang, J. -P., Zhang, K. Y. B., Zhang, L. W., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X. -W., Zhang, X. D., Zhang, Y., Zhang, Y. -D., Zhang, Y. -Y., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X. -F., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X. -L., Zheng, Y., Zheng, Z. -G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, J., Zhou, K., Zhou, R., Zhou, X. -J., Zhou, Y., Zhou, Z. -Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G. -Q., Zhu, H., Zhu, W. -G., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C. M., Ziviani, E., Zoladek, T., Zong, W. -X., Zorov, D. B., Zorzano, A., Zou, W., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X. C., Kenchappa, C. S., Lin, Y., Oshima, S., Rong, Y., Sluimer, J. C., Stallings, C. L., Tong, C. -K., and Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Programmed cell death, Settore BIO/06, Autophagosome, Autolysosome, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Autophagy-Related Proteins, Review, Computational biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Settore MED/04, 03 medical and health sciences, stress, Chaperone-mediated autophagy, ddc:570, Autophagy, LC3, Animals, Humans, cancer, Settore BIO/10, flux, lysosome, macroautophagy, neurodegeneration, phagophore, vacuole, Set (psychology), Molecular Biology, 030102 biochemistry & molecular biology, business.industry, Interpretation (philosophy), Autophagosomes, Cell Biology, Multicellular organism, 030104 developmental biology, Knowledge base, Biological Assay, Lysosomes, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021

34. Demystify Sharing Economy

Author: Ma Huateng, Cai Xiongshan, Sun Yi, and Zhang Xiaorong
Subjects: Market economy, Sharing economy, Business, Connotation, Gig economy
Abstract: Many scholars and institutions believe that sharing economy has a similar connotation to those of collaborative consumption, on-demand economy, gig economy, and so on. However, if you take a closer look, you’ll find that sharing economy, indeed, has some overlaps with them but actually, they’re horses of different colors, albeit seemingly similar outwardly.
Published: 2021

35. Design of domestic serial and parallel interface module

Author: Guowei Shao, Quanyu Sun, and Sun Yi
Subjects: lcsh:GE1-350, Universal asynchronous receiver/transmitter, Computer science, business.industry, Interface (computing), SerDes, Serial port, Chip, Embedded system, Field-programmable gate array, business, Parallel port, lcsh:Environmental sciences, PCI Express
Abstract: Domestic serial and parallel interface module is based on domestic high performance FPGA CPCIE module. This type of FPGA has rich logical resources and internal integration of a variety of high-speed interfaces, such as PCIE, high-speed Serdes interface, which can achieve serial port, time system, network and other interfaces design, greatly simplifying the hardware design of the module. The main communication interfaces, PCIE and UART, are realized by the IP core of FPGA, realizing the integration of the main functions on the chip, which greatly improves the flexibility and expansibility of the design.
Published: 2021

36. Declaration of Sharism

Author: Cai Xiongshan, Ma Huateng, Zhang Xiaorong, and Sun Yi
Subjects: Commerce, Goods and services, Sharing economy, Declaration, Business
Abstract: The sharing economy is shaking the foundations of traditional sectors based on the exchange of goods and services. We no longer see ownership as the best way to acquire products.
Published: 2021

37. Sharing Time Surplus: Playing Multiple Roles is in Vogue

Author: Sun Yi, Zhang Xiaorong, Ma Huateng, and Cai Xiongshan
Subjects: Boss, Business, Marketing
Abstract: In 2016, you can no longer need a “Nine-to-Five” job. Perhaps, you can be a free man wearing many hats or start a business and become “your own boss”. As playing multiple roles are in vogue, you may make such a decision.
Published: 2021

38. Idle Housing Sharing

Author: Cai Xiongshan, Zhang Xiaorong, Ma Huateng, and Sun Yi
Subjects: Idle, Renting, Loft, business.industry, Advertising, Space (commercial competition), business, Living room, Accommodation
Abstract: In October 2007, Joe Gebbia and Brian Chesky, two unknown college graduates, lived in a rented loft in San Francisco. A conference to be held there attracted many exhibitors and tourists, leading to an extreme short supply of hotel accommodation. The two students came across an idea: renting their living room in the loft to tourists for covering their rental for the loft. Acting without delay, Gebbia made the arrangment for the rental space: A few idle inflatable mattresses were laid out in the living room as the beds while Chesky log on to the local website to advertising their rental space. Everything went well.
Published: 2021

39. Current Status and Problems of Sharing Economy

Author: Ma Huateng, Sun Yi, Zhang Xiaorong, and Cai Xiongshan
Subjects: Sharing economy, Process (engineering), Scale (social sciences), Business, Economic system, Plenary session, China, Supply and demand
Abstract: Sharing economy has developed rapidly across the world, becoming an emerging driver of global growth in the post-financial crisis age. Relying on innovation platforms, it can match supply and demand in surplus resources with lower costs and at higher efficiency, and achieve the successful effect that “Every talent is given full play to and everything is made the best of”. According to some preliminary statistics, the global trading scale of sharing economy in 2015 was about USD 810 billion. The sharing economy in China is on the rise, and has made remarkable innovation achievements in the fields of leasing, travel, and so on. Even the Communique of the Fifth Plenary Session of the 18th CPC Central Committee also proposed to develop sharing economy. Yet, in the process of developing sharing economy, we still have many problems to be solved, which deserve our attention.
Published: 2021

40. Bean Extract-Based Gargle as Promising Tool for Efficient Diagnosis of COVID-19 at Early Stage Using Rapid Antigen Tests: A Clinical, Prospective, Diagnostic Sensitivity Study

Author: Young-Ho Lee, Jong-Soon Choi, Sang Min Lee, Dong Im Kim, Duwoon Kim, Sung Ho Yun, Joseph Sang-Il Kwon, Sangmi Jun, Jeong-Hwan Hwang, Namsu Kim, Kyeong Eun Yang, Mi-Kyung Song, Dai Ito, Yoon-Sun Yi, Eunae Jo, Bipin Vaidya, Kyuhong Lee, Hee-Chung Chung, Euna Ko, Soyoung Cha, Dal Sik Kim, Sun Cheol Park, Joo-Hee Hwang, Hye-Yeon Kim, Se-Young Cho, Eunha Hwang, and Yuxi Lin
Subjects: History, Saliva, medicine.medical_specialty, Rapid diagnostic test, Polymers and Plastics, business.industry, Institutional review board, Asymptomatic, Industrial and Manufacturing Engineering, Antigen, Internal medicine, Medicine, Sample collection, Business and International Management, medicine.symptom, Stage (cooking), business, Mass screening
Abstract: Background: Antigen based rapid diagnostic test (Ag-RDT) is faster and applicable for self-testing of SARS-CoV-2. Nasopharyngeal swab (NPS) is not technically feasible for self-testing due to requirement of heath professional and risk of contaminated aerosol during sample collection. Thus, saliva specimen can be appropriate for self-sampling technique required for Ag-RDT. However, the detection of virus by Ag-RDT in saliva could be less sensitive. Therefore, we aimed to evaluate novel Beanguard gargleTM (BG)-based virus collection method that can be applied to antigen-rapid detection test (Ag-RDT) as an alternative to the current RT-PCR with a nasopharyngeal swab (NPS) for early diagnosis of COVID-19. Methods: Paired BG-based saliva and NPS specimens were collected from 102 patients with COVID-19 and 100 healthy subjects. The diagnostic performance of Ag-RDT (BG-Ag-RDT) and RT-PCR (BG-RT-PCR) of BG-based saliva specimens for SARS-CoV-2 detection was compared to NPS-RT-PCR. Physical interactions between the bean extract (BE) in BG and SARS-CoV-2 were evaluated using cryo-electron microscopy (cryo-EM), isothermal titration calorimetry, and ELISA. Findings: BG-Ag-RDTs showed high sensitivity (97·8%) and specificity (100%) in all patients within 6 days of illness associated with the infection of SARS-CoV-2 along with Alpha and Delta variants. Notably, in 11 asymptomatic early-stage cases, both BG-Ag-RDTs and BG-RT-PCR showed excellent performance with sensitivity and specificity of 100%. The interaction between SARS-CoV-2 spike proteins and truncated canavalin, an active ingredient from BE, was shown by calorimetry. The ultrastructural features of SARS-CoV-2 particles coated by BE were well observed in cryo-EM, and the detachment of the receptor binding domain of SARS-CoV-2 from hACE2 was increased with increasing concentration of BE in ELISA, allowing us to apply for releasing the virus from hACE2 in the oral cavity to early diagnosis. Interpretation: BG-based saliva specimens applied to Ag-RDT can be an alternative to NPS-RT-PCR for early diagnosis of COVID-19. The method can facilitate self-testing without trained healthcare workers for mass screening, surveillance, and efficient quarantine. Funding: BIO3S, Inc., Korea Basic Science Institute, and Jeonbuk National University Hospital. Declaration of Interest: DSK received grant support for clinical study from BIO3S, Inc. DK, JK and BV were involved in developing Beanguard gargleTM. All disclosures are unrelated to present clinical study. All other authors declare no competing interests. Ethical Approval: Ethical approval for the study was granted by the Institutional Review Board of Jeonbuk National University Hospital (CUH 2021-04-036-002) and written informed consent statements were obtained from all participants.
Published: 2021

41. China’s Response

Author: Ma Huateng, Cai Xiongshan, Zhang Xiaorong, and Sun Yi
Subjects: ComputingMilieux_GENERAL, Entrepreneurship, Sharing economy, State (polity), Order (exchange), Service (economics), media_common.quotation_subject, Social change, Business, Economic system, China, media_common
Abstract: In China, the concept of a “sharing economy” was first proposed in the Guiding Opinions on Accelerating the Development of Platforms to Support Widespread Innovation and Entrepreneurship (GF [2015] No. 53) issued by the State Council on September 26, 2015. It is pointed out in the document that, given the rapid growth of the sharing economy worldwide, China must develop its sharing economy and cultivate new areas of economic growth, in order to seize development opportunities and amass new forces to drive economic and social development. At the same time, it would be necessary to promote novel “sharing economy service models” that integrate and utilize idle, dispersed private resources to stimulate entrepreneurship and innovation.
Published: 2021

42. On-Demand Comes on the Heels of Sharing

Author: Ma Huateng, Zhang Xiaorong, Cai Xiongshan, and Sun Yi
Subjects: Market economy, Sharing economy, On demand, Phenomenon, Perspective (graphical), Business, Front (military), Domain (software engineering)
Abstract: The important article: Workers on Tap in the Economist in January 2015 briefed on a late phenomenon: employees can act like tap water, coming and going on demand and without being present in front of their bosses every day. It opens up a new domain (on-demand economy) for sharing economy from the “on-demand” perspective.
Published: 2021

43. Globalization and the sustainability of large current account imbalances: Size matters

Author: Aizenman, Joshua and Sun, Yi
Subjects: Sustainable development -- Analysis, Gross domestic product -- Growth, Globalization -- Analysis, Company growth, Business, Economics
Abstract: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jmacro.2009.11.001 Byline: Joshua Aizenman (a), Yi Sun (b) Keywords: Current account imbalances; Growth; Size; Adding-up property Abstract: This paper evaluates the sustainability of large current account imbalances in the era when the Chinese GDP growth rate and current account/GDP exceed 10%. We investigate the size distribution and the durability of current account deficits during 1966-2005, and report the results of a simulation that relies on the adding-up property of global current account balances. Excluding the US, we find that size does matter: the length of current account deficit spells is negatively related to the relative size of the countries' GDP. We conclude that the continuation of the fast growth rate of China, while maintaining its large current account/GPD surpluses, would be constrained by the limited sustainability of the larger current account deficits/GDP of courtiers that grow at a much slower rate. Consequently, short of the emergence of a 'new demander of last resort', the Chinese growth path would be challenged by its own success. Author Affiliation: (a) Economics E2, UCSC and NBER, Santa Cruz, CA 95064, United States (b) Economics E2, UCSC, Santa Cruz, CA 95064, United States Article History: Received 20 September 2008; Accepted 25 November 2009
Published: 2010

44. A location-allocation problem for a web services provider in a competitive market

Author: Aboolian, Robert, Sun, Yi, and Koehler, Gary J.
Subjects: Electronic commerce -- Computer programs, Competition (Economics), Web services, Electronic commerce software, Web services, Business, Business, general, Business, international
Abstract: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ejor.2007.11.057 Byline: Robert Aboolian (a), Yi Sun (a), Gary J. Koehler (b) Keywords: Web Services; Competitive facility location models; Nonlinear integer programming Abstract: Web Services have become a viable component technology in distributed e-commerce platforms. Due to the move to high-speed Internet communication and tremendous increases in computing power, network latency has begun to play a more important role in determining service response time. Hence, the locations of a Web Services provider's facilities, customer allocation, and the number of servers at each facility have a significant impact on its performance and customer satisfaction. In this paper we introduce a location-allocation model for a Web Services provider in a duopoly competitive market. Demands for services of these servers are available at each node of a network, and a subset of nodes is to be chosen to locate one or more servers in each. The objective is to maximize the provider's profit. The problem is formulated and analyzed. An exact solution approach is developed and the results of its efficiency are reported. Author Affiliation: (a) College of Business Administration, California State University San Marcos, San Marcos, CA 92096, USA (b) The Warrington College of Business Administration, University of Florida, Gainesville, FL 32611, USA Article History: Received 4 April 2005; Accepted 20 November 2007
Published: 2009

45. UHVDC Tie-line Scheduling Model Based on Conditional Value-at-Risk

Author: Deyue Men, Zhi Cai, Sun Yi, Guofang Zhang, Hu Xiaojing, Xiaming Guo, and Dawei Zhang
Subjects: Power transmission, Expected shortfall, Wind power, business.industry, Computer science, CVAR, Photovoltaic system, Scheduling (production processes), Thermal power station, AC power, business, Reliability engineering
Abstract: There is a growing demand for trans-regional transmission of clean energy such as wind power and photovoltaic power through ultra-high voltage direct current (UHVDC) system. To solve the problem of difficulty in transmission of new energy through UHVDC due to random fluctuations, this paper puts forward a transmission scheme of using the supporting thermal power to smooth power fluctuation of new energy and realize bundled transmission, establishes an integrated tie-line scheduling model of wind power, photovoltaic power and thermal power transmission through UHVDC system, and introduces the conditional value-at-risk (CVaR) theory according to the concept of new energy transmission risk to quantify the new energy transmission risk, for analyzing the new energy transmission capacity of tie-line scheduling under different confidence levels and risks. The model is applied to a practical calculation example, and the calculation result shows the effectiveness of the proposed method.
Published: 2020

46. Research on radiation damage of fiber optical fiber ring for fiber optic gyroscope

Author: Pengwei Li, Bo Mei, Hongwei Zhang, Qingkui Yu, Rigen Mo, Lyu He, Li Xiaoliang, and Sun Yi
Subjects: Optical fiber, Materials science, genetic structures, business.industry, Gamma ray, Physics::Optics, Optical power, Fibre optic gyroscope, eye diseases, law.invention, Optics, law, Radiation damage, sense organs, Fiber, Irradiation, business, Radiation resistance
Abstract: With the development of space technology, more and more Fiber optic gyroscope is used in spacecraft and satellite. Due to the existence of space radiation environment, it will cause serious damage to some components in the Fiber optic gyroscope, especially the fiber ring, and have an important impact on the optical power transmission of the fiber ring. In recent years, the research shows that space irradiation has serious damage to optical elements. In this paper, for a 1550 nm Panda optical fiber, the influence of the radiation damage of this kind of optical fiber is obtained by gamma ray and electron source irradiation respectively. The transmission loss of the fiber is up to 17.5 dB/km after 1Mrad (Si) is irradiated by gamma ray, and 53.2 dB/km after 5×1015/cm2 electrons is irradiated by 0.2MeV electron source. Compared with the previous 1310 nm optical fiber irradiation damage, and through the analysis of the mechanism of optical fiber irradiation damage, it is concluded that the impact of 1550 nm optical fiber irradiation damage is greater than that of 1310 nm optical fiber irradiation damage. In addition, for the degradation of 1550 nm optical fiber, the influence of fiber radiation damage on the bias drift and random walk of the whole fiber optic gyroscope system is analyzed. Finally, based on the radiation damage mechanism of optical fiber and the experimental results of radiation damage of optical fiber, some suggestions on the radiation resistance design of optical fiber ring are given.
Published: 2020

47. Evaluation of skin phototoxicity of transdermally administered pharmaceuticals in Sprague-Dawley rats

Author: Nam Hee Youn, Eun Ji Kim, Ki Sook Park, Jung-Sun Yi, Joo Hwan Kim, Jong Kwon Lee, Ki Taek Nam, and Yejin Cho
Subjects: Drug, Erythema, media_common.quotation_subject, Histopathology, Pharmacology, Skin reaction, 030226 pharmacology & pharmacy, Phototoxicity, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Sprague dawley rats, lcsh:QH301-705.5, media_common, Transdermal, lcsh:R5-920, In vivo test, business.industry, Research, Phototoxicity Study, Skin irritation, lcsh:Biology (General), 030220 oncology & carcinogenesis, medicine.symptom, lcsh:Medicine (General), business
Abstract: Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established. This study aimed to establish an in vivo phototoxicity test method for transdermally administered drugs. For this, we evaluated the phototoxicity using Sprague-Dawley (SD) rats for transdermal administered drugs and we studied the appropriate UVA dose using 8-methoxypsalen, which is a well-known phototoxic drug. We found that a UVA dose of 15 J/cm2 was dose and time dependent response compared to other UVA doses. We performed the Minimum Erythema Dose (MED) test because UVB can cause skin irritation by itself and selected 0.01 J/cm2 as an appropriate dose of UVB. Using the selected UVA and UVB doses, we performed a phototoxicity study of 6 pharmaceutical drugs, which included phototoxic and non-phototoxic drugs. As a result of the phototoxicity test, 100% accuracy was obtained when compared with previous studies. In addition, we performed histopathology to confirm the new findings. We found that histopathology can be used as an additional indicator of phototoxicity test for transdermally administered drugs.
Published: 2020

48. An Android-based mobile paratransit application for vulnerable road users

Author: Sun Yi, Kelvin Kwakye, and Younho Seong
Subjects: business.industry, Computer science, Internet privacy, Reservation, Mobile apps, 02 engineering and technology, Time of day, User experience design, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Android (operating system), business, Paratransit, Road user
Abstract: Making an optimal travel plan is not an easy task, mostly for vulnerable road users like the elderly and people with mobility disabilities. This optimal travel plan is dependent on the time of day to travel, the route to ply, ways to navigate, and suitable mode of transportation as these vulnerable road users need to reserve paratransit ahead of time. Researchers and mobile app developers are faced with difficulties in incorporating all necessary information that would ease navigation and bus riding for vulnerable road users (that is, making a more assistive system for vulnerable road users). In response to these challenges, this research is designed to develop an interactive android mobile application to ease and significantly encourage vulnerable road users (VRUs) especially the elderly and the disabled to use paratransit to improve their traveling experiences. This paper assesses the challenges facing the paratransit service. It provides an improvement in areas of reservation, dispatch & routing, and user experience. In response to these challenges, an interactive android mobile application has been developed to ease and significantly encourage vulnerable road users (VRUs) especially older adults and the disabled to use paratransit services and improve their traveling experiences.
Published: 2020

49. Integrated Generation-Grid-Load Economic Dispatch Considering Demand Response

Author: Sun Yi, Si Yang, Fu Yimu, Bin Yang, Xueliang Li, Yiqun Wang, Donglei Sun, and Zhao Long
Subjects: Demand response, Load management, Electric power system, Mathematical optimization, Electric power transmission, Wind power, Electricity generation, Computer science, business.industry, Economic dispatch, business, Grid
Abstract: In response to the wind curtailment problem with the increasing large-scale wind power integration, the integrated generation-grid-load economic dispatch method considering demand response is proposed in this paper. Through integration of the optimization of power grid structure and load side demand response into the traditional power generation economic dispatch model, the flexibility resources of generation-grid-load sides in power systems are mobilized to promote large-scale wind power integration consumption. The proposed integrated generation-grid-load economic dispatch mathematical model is transformed into a mixed integer programming model through introduction of the big M method. The analysis of practical examples indicates that the proposed integrated generation-grid-load economic dispatch considering demand response can reduce wind power curtailment and improve the economy of power system operation.
Published: 2020

50. Effects of Self-efficacy and Self-control on Internet Addiction in Middle School Students: A Social Cognitive Theory-Driven Focus on the Mediating Influence of Social Support

Author: Sun-Yi Yang
Subjects: media_common.quotation_subject, education, Addictive behavior, 030508 substance abuse, lcsh:Medicine, Pediatrics, Social support, 03 medical and health sciences, 0302 clinical medicine, medicine, media_common, Self-efficacy, Focus (computing), Internet, business.industry, Addiction, lcsh:R, Self-control, medicine.disease, 030227 psychiatry, Self efficacy, Pediatrics, Perinatology and Child Health, The Internet, Original Article, 0305 other medical science, Psychology, business, Social psychology, Social cognitive theory
Abstract: Purpose: The aim of this study was to investigate internet addiction among middle school students and to examine the mediating effects of social support in the relationships of self-efficacy and self-control with internet addiction.Methods: The participants in the study were 119 middle school students in J city. The measurements included a self-efficacy scale, a self-control scale, a social support scale, and the Internet Addiction Scale for Youth. Data were analyzed using the independent t-test or Mann-Whitney U test, one-way analysis of variance, the Scheffé test, Pearson correlation coefficients, and multiple-regression using SPSS version 22.0. Mediation effects were analyzed by the Sobel test and Baron and Kenny's hierarchical analysis technique.Results: Significant correlations were found among self-efficacy, self-control, and internet addiction. Social support had partial mediating effects in the relationship between self-efficacy and internet addiction, as well as in the relationship between self-control and internet addition.Conclusion: In order to prevent internet addiction, the promotion of interactions among peers, which is a component of social support, is particularly important. It is also necessary to promote face-to-face activities that can strengthen relationships. The findings suggest that intensifying social support may help reduce the level of internet addiction in middle school students.
Published: 2020

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