Search

Your search keyword '"S.T. Holgate"' showing total 17 results
Start Over Author "S.T. Holgate" Topic business
17 results on '"S.T. Holgate"'

1. The Roles of Cells and Mediators in a Computer Model of Chronic Asthma

Author

C.L. Stokes, T. Paterson, A.K. Lewis, C.C. Leong, Nadine Defranoux, and S.T. Holgate

Subjects
Allergy, business.industry, medicine.medical_treatment, Immunology, General Medicine, Eosinophil, medicine.disease, Allergen challenge, Pathogenesis, medicine.anatomical_structure, Cytokine, Chronic asthma, Immunology and Allergy, Medicine, business, Interleukin 5, Asthma
Published
2001
Full Text
View/download PDF

2. Asthma: basis and management at different ages

Author

S.T. Holgate, N. Chanarin, and J. Corne

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pediatrics, business.industry, Medical school, Airway obstruction, medicine.disease, Early life, respiratory tract diseases, Respiratory Medicine, Epidemiology, Medicine, Young adult, business, Asthma
Abstract

The first half of the meeting was devoted to the early life origins of asthma and opened with an address from Michael Silverman (Paediatric Respiratory Medicine at the Royal Postgraduate Medical School, London, U.K.). There are problems with the proper definition of early asthma in childhood, and the concepts of asthma which have been derived from clinical and epidemiological work on school children and young adults cannot be applied to pre-school children. If one sticks to a definition of asthma as a. chronic inflammatory condition in which heightened bronchial responsiveness is associated with recurrent, reversible airway obstruction, then the syndrome of asthma cannot be shown to exist in this age group. There is no evidence concerning the nature or persistence of an inflammatory process in the airways of wheezy young children. There is also no evidence to support a greater degree of bronchial responsiveness in wheezy infants (or in any wheezy children up to the age of 7 years) compared with their non-wheezy counterparts. Finally, there are few, if any, data on the variability of airway obstruction with time in children with wheezing conditions under 5 years of age.

Published
1995
Full Text
View/download PDF

4. Contents, Vol. 94, 1991

Author

Graham S. LeGros, Hiroshi Yamakawa, K. Takatsu, Ratko Djukanovic, P.G. Holt, J. Bujanowski-Weber, P. Oehme, S. Bianchj, William Roche, I. Knöller, G. Delespesse, Toru Ando, Reinhold Penner, D. Macchia, R. Djukanovic, George W. Ward, Thomas Bieber, T. Furitsu, Makoto Dohi, Susan M. MacDonald, Martin D. Chapman, F. Chavarria, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, John R. Brashler, J. Brom, Pascal Chanez, A. Ciccarelli, T.D. Whalley, M.J. Carmona, E. Saito, Mamoru Ito, H. Behrendt, W. Zachgo, Gabriele Zwadlo-Klarwasser, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, A. de Paulis, G. Schultze-Werninghaus, J.-P. Kinet, B.D. Gomperts, Takeo Juji, Ikuo Akutsu, Richard J. Simpson, S. Wilson, T.H. Lee, Suhad El-Lati, Bernhard Przybilla, J. Oliver, Sesha Reddigari, Monique Vogel, Koki Takahashi, Thomas Iff, L. Mugnai, E. Neher, Nathalie Paul-Eugène, Ph. Lassalle, Takeshi Fukuda, Dean D. Metcalfe, V. Lagente, C.E. O’Neil, Go Matsuzaki, C. McMenamin, Jordan N. Fink, G. Burow, Ch. Lemmermann, Ch. Schweiger, H. Wagner, K. Kurihara, D.R. Springall, Karin Pettenburger, A. Capron, H.Y.A. Lau, R. Wahl, G.J. Gleich, K. Rother, Shigeru Takafuji, W.R. Roche, Kurt Blaser, F. Gambassi, A. Pistelli, M. Bubak, Andrew F. Walls, Jeffrey M. Drazen, S.J. Lane, Johann-Christian Virchow, Akio Mori, J.M. Polak, Dietrich Kraft, Hans L. Spiegelberg, L. Lipponer, Friederike von zur Mühlen, R. zur Strassen, Rihoux Jean-Pierre, Susanne Spitzauer, Werner J. Pichler, Karen Britten, M. Schon-Hegrad, Barbara K. Stout, John Wilson, Hirokazu Okudaira, Otto Scheiner, Mitsuko Kondo, Akira Ishii, Richard Sporik, Daniel Weinreich, M. Keating, W. Dorsch, Manel Jordana, Ch.H. Heusser, Ingrid Enander, Massimo Triggiani, T. Ishizaka, Colin J. Sanderson, Dieter Vieluf, Stephanie A. Shore, J. Anrather, S. Terrados, Claus Bachert, Rosa M. Ten, E.W. Rauterberg, E. Masini, H. Rumpold, Jean Yves Lacoste, T.H.W. Lillie, K. Ohno, Alison M. Campbell, E. Gutierrez, F.L. Pearce, Stephan C. Bischoff, R. Suau, Miguel Blanca, P.H. Howarth, P.K. Jeffery, Robert L. Barker, E. Perez, M. Pfenning, Marshall Plaut, Piotr Kuna, T. Abe, H. Rotermund, Michael A. Lett-Brown, Herbert G. Johnson, Thomas Brunner, C. Ra, U. Ganzer, N. Hyslop, Kazuhiko Akiyoshi, Alain L. de Weck, J. Bews, A. Hartnell, J. Dry, K. Nosbüsch, Rafeul Alam, G. Le Gros, V. Brinkmann, Jacqueline M. Langdon, B. Thomas, P. Heap, Corinne Petit-Frère, A.G. Fernández, Wolfgang Schmutzler, Gianni Marone, Matsunobu Suko, R.W. Gristwood, D. Kraft, G.M. Walsh, A.G. Palma-Carlos, B. Bradley, N.S. Sakaguchi, J.M. Vega, O.-H. Wilhelms, R. Wiewrodt, A. Brini, Stephen R. Durham, M. Lupini, M.A. Reed, Thierry Maisonnet, A. Witzel, Peter J. Barnes, Ch. Brander, Lawrence M. Lichtenstein, A. Koffer, Y. Delneste, Laura Palma-Carlos, Jennifer Cairns, T. Brunnee, Elliott Homer, Diana J. Quint, F. Bettens, Monique Capron, Sohei Makino, Luanda Beck, T. Imai, Takayuki Ohtoshi, A. Akasawa, Lore Koller, Yoji Iikura, Naohiro Watanabe, Ahuva Nissim, J.W. Coleman, A. Ohgimi, D. Befus, J.R. Wilkinson, H. Küster, T. Katsunuma, Ch. Ebner, K.J. Turner, M.P. Piccinni, F. Ledermann, Michael Breitenbach, Bradley J. Undem, A.B. Kay, John E. Salvaggio, Carvalho de Sousa, S.T. Holgate, B. Girn, P. Berga, S. Bent, Gerald J. Gleich, Arnold S. Kirshenbaum, P.B. Boulos, Yoshitaka Ino, M. Breitenbach, R. Rathsack, May Azzawi, Sun Ying, Philippe Godard, J.H. Widdicombe, Rudolf Valenta, Christopher Corrigan, S. Romagnani, D.M. Kemeny, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, John Gordon, C. Brom, F. Leynadier, Gert Kunkel, Gerard Cox, B.F. Weber, D. Diaz-Sanchez, Shinji Motojima, J.W. Wilson, Pieter L.B. Bruijnzeel, P.F. Mannaioni, K. Britten, Allen P. Kaplan, Yutaka Morita, K. Ishida, Erika Jensen-Jarolim, Jack Gauldie, Fiona R. Lake, S. Raspanti, Andrew Grant, R. Fadel, S. Dunnette, Jean Bousquet, Ivan Aebischer, Thomas A.E. Platts-Mills, T. Wyss, Richard D. O’Connor, Larry D. Ward, A.G. Morris, Clemens A. Dahinden, Toshifumi Yuuki, P. Parronchi, Hiroyuki Mochizuki, Gail M. McNutt, D.C. Reason, Martin Krieger, Lawrence E. Gelber, Naoki Inagaki, E. Kilchherr, Elisabeth Boichot, Qiu Gang, F. Gabl, Alec H. Sehon, J.V. Collins, Shiro Kasuya, J. Blomgren, Bernadette Pignol, Motohiro Ebisawa, N. Sakaguchi, Jacalyn H. Pierce, U. Blank, Fu-Tong Liu, Robert A. Seder, R. Hilger, Richard P. Bransford, M. Linssen, Jörg Kleine-Tebbe, P.D. Pare, Kazuhiko Yamamoto, Jean Michel Mencia-Huerta, Michael K. Bach, Pierre Braquet, J. Salvaggio, Reuben J.M. Falkoff, R. Merget, J. Hards, B.J. Holt, D. Strickland, P.E.R. Tatham, A.B. Tonnel, H. Saito, François-B. Michel, K. Akimoto, Jerry Dolovich, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, Tim R. Mosmann, Zelig Eshhar, N. Wallen, Maria Baeza, A.J. Wardlaw, Peter H. Howarth, Robin N. Poston, W. König, R.C. Benyon, M. Lopez, D. Mijic, E. Jarolim, William E. Paul, John P. Caulfield, B. Kunz, Milton A. Martins, Yasushi Okumura, J. Knöller, R. Ciriilo, K. Nieber, Geoffrey A. Stewart, Allen C. Myers, Zami Ben-Sasson, U. Hauser, M. G. Di Bello, Michael Duchêne, C. Baumgarten, C.J. Sanderson, Koji Ito, R. Valenta, M.-H. Jouvin, Menachem Rottem, F. Carswell, A. Miranda, K.R. Tainsh, Kimm J. Hamann, Judah A. Denburg, K. Wagner, Martin K. Church, Qutayba Hamid, O. Mejan, Johannes Ring, J. Fernandez, L. Juhlin, Kiyoshi Takatsu, Martin E. Sanders, Peter W. Heymann, C.E. Reed, P. Wentz-Murtha, Fred D. Finkelman, J. Llupiá, Helmut Rumpold, Stephen T. Holgate, Conceição B. Santos, G.M. Hänsch, W.L. Liu, Christoph Walker, M. Ricci, Ph. Gosset, E. Maggi, J. Wilson, R. Moqbel, and Beda M. Stadler

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1991
Full Text
View/download PDF

5. Controlled-Release Theophylline in the Treatment of Nocturnal Asthma

Author

R. Clarke, P.F. Mitchell-Heggs, D. MacLntyre, M. Turner-Warwick, T. Higenbottam, C.K. Connolly, R. Monie, C.E. Johnson, K. Whyte, W.T. McNicholas, S.S. Chatterjee, J.A. Hughes, R.N. Johnston, A.J. Fairfax, and S.T. Holgate

Subjects
Adult, Male, Vital capacity, Adolescent, medicine.drug_class, Nausea, Peak Expiratory Flow Rate, 030204 cardiovascular system & hematology, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Theophylline, Bronchodilator, Wheeze, medicine, Humans, Aged, Asthma, business.industry, Biochemistry (medical), Cell Biology, General Medicine, Middle Aged, medicine.disease, Crossover study, Symptomatic relief, respiratory tract diseases, Delayed-Action Preparations, 030220 oncology & carcinogenesis, Anesthesia, Female, Steroids, medicine.symptom, business, medicine.drug
Abstract

A total of 104 asthmatic patients with symptoms of asthma and/or a ‘morning dip’ in the peak expiratory flow rate (PEFR) who were receiving multiple therapies, including inhaled or oral steroids, were treated in addition once nightly with controlled-release theophylline in an 8-week double-blind, placebo-controlled crossover study. Theophylline produced an improvement in symptoms of cough, wheeze, sleep disturbance and PEFR in the 73 completing patients compared to run-in and placebo treatment. Theophylline also produced an improvement in the forced expiratory volume in 1 s and forced vital capacity relative to baseline, and in the difference between actual and predicted PEFR values. Nausea was the most frequent side-effect but both patients' and investigators' global impressions of the effect of study medication were in favour of theophylline.

Published
1990
Full Text
View/download PDF

8. Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma

Author

G.I. Town and S.T. Holgate

Subjects
Adult, medicine.drug_class, Immunology, Cyproheptadine, Histamine Antagonists, Bronchi, Histamine H1 receptor, Loratadine, medicine.disease_cause, Bronchial Provocation Tests, chemistry.chemical_compound, Allergen, Bronchodilator, medicine, Immunology and Allergy, Humans, Methacholine Chloride, Asthma, Skin, Skin Tests, integumentary system, business.industry, respiratory system, Allergens, Middle Aged, medicine.disease, Crossover study, respiratory tract diseases, chemistry, Anesthesia, Methacholine, Female, business, Histamine, medicine.drug
Abstract

Loratadine is a highly selective, long-acting, H1-receptor antagonist. In a randomized, double-blind, crossover study, we evaluated the effects of loratadine, 10 and 20 mg, and placebo administered once daily for 3 days on the skin-wheal responses to histamine, the airway responses to inhaled histamine and methacholine, and the skin-wheal and airway responses to allergen in 12 subjects with asthma. There was no evidence of a bronchodilator action 3 hours after a third oral dose. In the airways, the geometric mean of the provocative concentration of histamine causing a 20% fall in FEV1 after placebo or loratadine, 10 and 20 mg, was 0.68 mg/ml, 2.71 mg/ml (p, not significant), and 5.96 mg/ml (p less than 0.05), respectively. The concentration ratios (value after active treatment/value after placebo) for loratadine, 10 and 20 mg, were 5.1 (p less than 0.05) and 13.4 (p less than 0.05). Neither dose of loratadine had any significant effect on the methacholine dose-response relationship. In the skin, loratadine also displaced the histamine log-concentration response curves to the right with concentration ratios of 4.7 and 6.7, respectively. Loratadine, 10 and 20 mg, had no protective effect on the early or late-phase bronchoconstrictor responses to inhaled allergen. In the skin, loratadine, 20 mg, significantly inhibited the mean wheal area to allergen. Thus, in the dose regimens studied, although loratadine is a moderately potent and selective H1 antagonist in the skin and airways, it failed to attenuate the early and late airway responses to inhaled allergen.

Published
1990

10. Cellular and chemical mediators--their roles in allergic diseases

Author

S.T. Holgate and Sheryl L.G. Johnston

Subjects
Leukotrienes, T-Lymphocytes, Immunology, Human leukocyte antigen, Histamine Release, Biological Factors, Mice, Text mining, Hypersensitivity, Immunology and Allergy, Animals, Humans, Mast Cells, Platelet Activating Factor, Messenger RNA, Chemistry, business.industry, Neuropeptides, Immunoglobulin E, Basophils, Prostaglandins, Cytokines, Tumor necrosis factor alpha, business, Transforming growth factor
Published
1989

11. Theophylline

Author

M. Cushley and S.T. Holgate

Subjects
business.industry, medicine, Theophylline, Pharmacology, business, medicine.drug
Published
1984
Full Text
View/download PDF

12. INTRAVENOUS PREDNISOLONE IN ASTHMA

Author

S.T. Holgate and A.E. Tattersfield

Subjects
medicine.medical_specialty, Text mining, business.industry, Internal medicine, medicine, Prednisolone, MEDLINE, General Medicine, medicine.disease, business, Asthma, medicine.drug
Published
1976
Full Text
View/download PDF

13. Annual Review of Immunology, Vol. 4, 1986

Author

S.T. Holgate

Subjects
business.industry, Ipratropium, Scopolamine Derivatives, Parasympatholytics, Library science, General Medicine, Asthma, Bronchial Provocation Tests, Book Review, Acute Disease, Administration, Inhalation, Animals, Humans, Medicine, Drug Therapy, Combination, business
Abstract

Studies in both animals and man suggest a role for cholinergically-mediated reflex bronchoconstriction in the airflow limitation of asthma. Muscarinic cholinergic antagonists such as atropine, ipratropium bromide (IB) and oxitropium bromide (OB) when delivered locally to the airways are bronchodilators and antibronchoconstrictors. Although drugs like IB and OB offer advantages over some of the older anticholinergic preparations in terms of pharmacokinetics and therapeutic ratio, they cannot be considered as first line drugs in the therapy of acute asthma. However, when used in combination with other anti-asthma drugs, therapeutic benefit of inhaled IB and OB is obtained by maximising the bronchodilator properties of the individual drugs without attendant systemic side effects. Finally, the removal of the preservatives EDTA and benzylchonium chloride from Atrovent nebulizer solution has removed the risk of paradoxical bronchoconstriction occurring.

Published
1987
Full Text
View/download PDF

14. Beta adrenoceptors in asthma

Author

S.T. Holgate

Subjects
Pulmonary and Respiratory Medicine, Gerontology, business.industry, medicine, Beta adrenoceptor, medicine.disease, business, Asthma
Published
1985
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results