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Berardinelli-Seip Congenital Lipodystrophy (BSCL) is an autosomal recessive inborn error of the common pathway of acylglycerol and phospholipid synthesis. Patients with this condition present with generalized lipoatrophy, hepatomegaly, acromegalic features, hypertrichosis, and developmental delay. But on workup, they may also be discovered to have hypertriglyceridemia with or without hypercholesterolemia and insulin resistance. A high index of suspicion is required for diagnosis which may have implications in management. Here we present a 5-year old male with clinical features of BSCL. BSCL2 gene sequencing done showed a homozygous c.782dupG, p.(Ile262Hisfs*12) sequence alteration, classified as pathogenic, hence, confirming the diagnosis of BSCL. This is the first reported case in the Philippines.

The main purpose of this study is to obtain the water infiltration parameters of the soils of Michael Okpara University of Agriculture, Umudike. This could be used in simulating infiltration for these soils when designing irrigation projects, thereby saving time and cost of field measurement. Field measurements of infiltration were first made using a double ring infiltrometer. The test lasted for 180 mins in each location. Infiltration values ranged from 0.03 cm/min to 0.1 cm/min. The highest value was obtained in the Forest Block. Kostiakov’s infiltration model was then applied on the field data in order to determine the soils’ infiltration parameters and equations. The model empirical constants or parameters obtained were “m” and “n”. For “m” the values were: 0.53 for the soil of Forest Block, 0.42 for Poultry block, 0.50 for P.G. block, 0.41 for the soils of Staff School and Guest House. The corresponding “n” values were: 1.37, 1.12, 0.37, 1.79, and 1.38. Infiltration equations: 0.4It1.38, 0.4lt1.79, 0.42t1.12, and 0.53t1.37 were determined for the locations. These were used to simulate data which were evaluated by comparing them with the field data. The two data sets showed closed relationships. This implied that the model could be used to simulate water infiltration during irrigation projects in the farms of Michael Okpara University of Agriculture, Umudike.

Davao City is overlapped by 8 watersheds all flowing into the Davao Gulf. These watersheds exemplify a range of cultural, environmental and economic stresses from the continual conversion of natural habitat for agricultural, urban, and industrial uses. These changes and their consequent pressures have not gone unnoticed and have surfaced through various channels into the political and public arenas. However, despite the awareness and actions from various sectoral initiatives, there is continual deterioration of trends across the ecosystems.Hydrology for Environment, Life and Policy (HELP) is a global initiative which encourages policy makers, water managers, scientists, and end-users to work together within a field-oriented context to closely integrate science into government policies and management strategies. Through Davao City’s participation in the HELP Network, the management of watersheds and water has improved not through the acquisition of additional external funds but by the increase in opportunity for dialogue between ‘water-related’ communities, which resulted to enhanced stakeholder understanding of issues and increased technical capacity of all involved.This paper demonstrates how the HELP principles can be applied in basins with limited resources and how these can positively influence the attitudes and behaviour of stakeholders. It highlights how HELP can act as a catalyst to motivate learning, engage competing sectors, and build collaboration to create science-backed frameworks for good water governance.Keywords: HELP, watershed, ecosystems, twinning, community management, empowerment, good governance, collaboration, conflict

In vitro skin absorption methods exist in Organisation for Economic Co-operation and Development (OECD) guideline form (No. 428) and are used to estimate the degree of systemic penetration of chemicals through skin. More detailed kinetics of permeation through skin compartments are not described well by existing methods. This study was designed to assess the practical feasibility of generating compartmental (stratum corneum/epidermal/dermal) disposition and kinetic data of topically applied chemicals. For chemically induced effects initiated in the skin (e.g., skin allergy), the delivery of tissue concentrations of chemical will impact the incidence and severity of biological effect. Explicit data on the kinetics of chemical disposition in skin have not traditionally been needed for skin allergy risk assessment: current in vivo assays embody delivery implicitly. Under the 7th Amendment to the European Cosmetics Directive, in vivo assays (such as the local lymph node assay for skin sensitization) will not be permitted to assess cosmetic ingredients. New in vitro and in silico alternative approaches and ways of predicting risk of adverse effects in humans need to be developed, and new methods such as that described here provide a way of estimating delivered concentrations and the effect of formulation changes on that delivery. As we continue to deconstruct the contributing factors of skin allergy in humans, it will be useful to have methods available that can measure skin tissue compartment exposure levels delivered from different exposure use scenarios. Here we provide such a method. The method could also be used to generate useful data for developing in silico kinetic models of compartmental skin delivery and for refining data for skin delivery in relation to the evaluation of systemic toxicity.

Objectives Little is known about the influence of control beliefs on antiretroviral drug adherence in patients who migrated from sub-Saharan Africa to Europe. The aim of this study was to explore the differences in health locus of control and control beliefs between HIV infected patients from sub-Saharan Africa with and without a lifetime experience of migration. Methods A sample of 62 HIV infected consecutive patients referred to the HIV clinics at the University Hospital of Munster (Germany) and at the Rubaga Hospital Kampala (Uganda) were enrolled into this study. We compared three groups of patients: sub-Saharan African migrants, German patients, and local Ugandan patients. We used the German health and illness related control beliefs questionnaire (KKG), the Competence and control beliefs questionnaire (FKK), and the Powe Fatalism Inventory-HIV/AIDS-Version (PFI-HIV/AIDS-Version) and translated these scales into English and Luganda. In addition, the patients' sociodemographic, acculturation, clinical, and immunological data were registered. Results Significant results were shown in HIV related external locus of control between migrated sub-Saharan African and local Ugandan patients compared to German patients. General control beliefs showed no significant differences. In the PFI-HIV-Version, there was a significant difference between migrated sub-Saharan African and Ugandan patients compared to German patients. Conclusions Our data suggest that the experience of migration does not influence the locus of control. Compared to German HIV patients, African patients in general showed a significantly higher external health locus of control which might have implications for drug adherence.

A computerized 24-h diet recall interview program (EPIC-SOFT) was developed for use in a large European multi-center study, namely the European Prospective Investigation into Cancer and Nutrition (EPIC). This program, which was adapted for each participating country and translated into nine languages, was developed to standardize interviews between the 22 EPIC centers. Common rules were pre-entered into the system to describe, quantify and probe approximately 1500-2200 foods and 150-350 recipes. Common methods used to classify and export the EPIC-SOFT dietary data facilitate their exchange, comparison and analysis. So far, EPIC-SOFT is the only available computerized 24-h diet recall system developed to provide comparable food consumption data between several European countries.

Passive intervertebral motion (PIVM) of the lumbar spine during forward bending was assessed independently during two grading trials by two physical therapists. The therapists each had a minimum of two years clinical experience with similar orthopaedic manual therapy skills, including the sidelying double leg technique utilized in this study. Six segments of the lumbar spine were graded as normal, hypomobile, or hypermobile. Subjects were six volunteers who had a history of low back pain (LBP) and were currently experiencing LBP symptoms. Each therapist graded the segmental mobility during two different trials to investigate both intra- and inter-examiner reliability. Data were analyzed by percent agreement, and Scott's pi 0 which is an indicator of reliability greater than that expected to occur by chance with nominal data. Results demonstrated intra-examiner reliability of 66.67% and 75.00%, with agreement greater than chance of 41.89% and 61.29% respectively. Inter-examiner reliability was 48.6...