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Medical therapy for hydrocephalus includes the administration of medications to limit the production of the cerebrospinal fluid (CSF) resulting in reduced intracranial pressure (ICP). This report describes the clinical findings in one dog with congenital hydrocephalus that was unresponsive to conventional medical treatment (steroids) but demonstrated good response to omeprazole when this drug was added to the steroid. Omeprazole might decrease the CSF production by about 26% according to experimental studies with healthy dogs, but the usage of the omeprazole in clinical trials with affected dogs such as hydrocephalic animals is lacking. The results of this report might suggest that omeprazole can be used added to steroids to ameliorate the neurological status in dogs with increased ICP by hydrocephalus.

This paper reports a case of nonpapillary and infiltrative transitional cell carcinoma (TCC) of the urinary bladder with metastasis of lumbar vertebrae and spinal cord compression in an adult female ocelot (Leopardus pardalis), from the Mato Grosso state, Brazil. The ocelot had pelvic limb paralysis and skin ulcers in the posterior region of the body and was submitted to euthanasia procedure. At necropsy was observed a multilobulated and irregular shaped, yellowish to white nodule in the urinary bladder. The nodule had a soft consistency and arised from the mucosa of the urinary bladder extending throughout the muscular layers and the serosa. Nodules of similar appearance infiltrating the vertebral column the at L6 and L7 vertebrae with corresponding spinal canal invasion were also observed. The histological evaluation showed epithelial neoplastic proliferation in the urinary bladder with characteristics of nonpapillary and infiltrative TCC, with positive immunohistochemical staining for pancytokeratin, and strong immunostaining for cytokeratin of low molecular weight, and weak or absent labeling for high molecular weight cytokeratin. This is the first report of TCC of urinary bladder in ocelot in Brazil. O presente trabalho relata um caso de carcinoma de células de transição (TCC) da bexiga urinária com metástase em vértebras lombares e compressão da medula espinhal em uma jaguatirica fêmea adulta (Leopardus pardalis), no estado do Mato Grosso. A jaguatirica manifestava paralisia de membros pélvicos e úlceras de decúbito na região posterior do corpo e foi submetida a eutanásia. Na necropsia observou-se um nódulo multilobulado e irregular, brancoamarelado na bexiga urinária, de consistência macia com origem na mucosa vesical e que se estendia às camadas musculares e à serosa. Nódulos de aspecto semelhante infiltrando as vértebras L6 e L7 e invasão do canal vertebral correspondente. No exame histológico foi observada proliferação neoplásica na bexiga urinária com com características de TCC não papilar e infiltrativo, com marcação imuno-histoquímica positiva para pancitoqueratina, forte marcação para citoqueratina de baixo peso molecular e fraca ou inexistente para citoqueratina de alto peso molecular. Este é o primeiro relato de TCC em bexiga urinária de jaguatirica no Brasil.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:50Z No. of bitstreams: 1 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) Made available in DSpace on 2013-08-22T18:59:50Z (GMT). No. of bitstreams: 1 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) Previous issue date: 2007-04-01 Made available in DSpace on 2013-09-30T19:57:14Z (GMT). No. of bitstreams: 2 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) S0103-84782007000200045.pdf.txt: 13770 bytes, checksum: 3d7e9060c9276296d746e36adf7d6e95 (MD5) Previous issue date: 2007-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:51Z No. of bitstreams: 2 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) S0103-84782007000200045.pdf.txt: 13770 bytes, checksum: 3d7e9060c9276296d746e36adf7d6e95 (MD5) Made available in DSpace on 2014-05-20T15:14:51Z (GMT). No. of bitstreams: 2 S0103-84782007000200045.pdf: 113853 bytes, checksum: 96554d7db0612763c74508f92b81ee95 (MD5) S0103-84782007000200045.pdf.txt: 13770 bytes, checksum: 3d7e9060c9276296d746e36adf7d6e95 (MD5) Previous issue date: 2007-04-01 O desvio vascular portossistêmico pode ser congênito ou adquirido nos cães. A enfermidade pode levar a alterações neurológicas decorrentes de encefalopatia hepática e a hiperamonenia é um dos mecanismos implicados na fisiopatologia deste quadro. O tratamento clínico visa a reduzir os níveis séricos de amônia com o uso de antibióticos e lactulose. em humanos com hepatopatias, os probióticos podem ser utilizados para reduzir a hiperamonemia. A resposta clínica e laboratorial de um cão com desvio vascular portossistêmico foi demonstrada com a utilização de lactulose e de probiótico, isoladamente e associados, sendo que a melhor evolução foi obtida na terapia conjunta. The portosystemic shunt may be congenital or acquired in dogs. The disease can cause neurologic signs manifested by hepatic encephalopathy. The hyperammonemia is a mechanism involved on the physiopathology of this disorder. The objective of the clinical treatment is to decrease the levels of ammonia with antibiotics and lactulose. In human medicine, probiotics are used to reduce the hyperammonemia in patients with hepatic diseases. This report compares the use of lactulose and probiotic monotherapy and in association in a dog with congenital portosystemic shunt, showing the patient s clinical and laboratorial evolutions. The better clinical and laboratorial reponse was obtained with the association of lactulose and probiotic. Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária

Osteoarthritis (OA) is the most common joint disease in both humans and animals, and it results in movement restriction and pain at the affected area. This disorder affects more than 25% of people over 60 years of age, and it is considered universal for 70-year-old people. OA is estimated to affect over 20% of the canine population from the United States of America. The present study aimed to evaluate the treatment of rats that were surgically induced to OA using two different drug therapies, one with pentosan polysulfate, one with betamethasone, and one with chondroitin sulfate/ glucosamine. In order to produce joint disease, the cranial cruciate ligament was surgically transected. Animals were kept and treated for eight days after surgery and were assessed via both radiographies and tomographies taken before surgery and eight weeks later. All animals were euthanized having both macroscopic and microscopic analysis performed to evaluate the disorder progression and therapeutic action. Macroscopic analysis showed lesion in the knees subjected to OA induction. The untreated animals presented major lesions whereas the treated ones presented mild to moderate lesions. In conclusion, pentosan polysulfate is recommendable for the treatment of iatrogenic joint lesions in rats since the other treatments showed no significant difference.

Este trabalho trata-se do relato da implantação e do desenvolvimento do Curso de Diagnóstico por Imagem (radiologia e ultrassonografia) abdominal em animais de companhia. O presente estudo teve como objetivo descrever a experiência da educação a distância (EaD como uma modalidade eficaz para proporcionar o ensino da subespecialidade) Diagnóstico por Imagem na medicina veterinária. Acredita-se que a EaD pode constituir-se em ferramenta pedagógica adequada para qualificar médicos veterinários que não têm acesso aos processos convencionais de pós-graduação, pois estão geograficamente dispersos ou mesmo não têm disponibilidade de afastar-se do seu cotidiano de vida profissional. Dessa forma, pode-se concluir que a referida técnica é uma estratégia pedagógica possível, confirmada pela certificação final em média de 70% dos discentes participantes.